296,998 results match your criteria Temporal Arteritis


A Novel Variant of the FZD4 Gene in a Chinese Family Causes Autosomal Dominant Familial Exudative Vitreoretinopathy.

Cell Physiol Biochem 2018 11;51(5):2445-2455. Epub 2018 Dec 11.

Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou,

Background/aims: Familial exudative vitreoretinopathy (FEVR) is a complex hereditary eye disorder characterized by incomplete development of the retinal vasculature, thereby affecting retinal angiogenesis.

Methods: In this study, a Chinese autosomal dominant FEVR pedigree was recruited. Ophthalmic examinations were performed, targeted next-generation sequencing was used to identify the causative gene, and Sanger sequencing was conducted to verify the candidate mutation. Read More

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December 2018
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Neural architecture supporting active emotion processing in children: A multivariate approach.

Neuroimage 2018 Dec 8. Epub 2018 Dec 8.

Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Background: Adaptive emotion processing is critical for nearly all aspects of social and emotional functioning. There are distinct developmental trajectories associated with improved emotion processing, with a protracted developmental course for negative or complex emotions. The specific changes in neural circuitry that underlie this development, however are still scarcely understood. Read More

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December 2018

Postoperative antiplatelet therapy in the treatment of complex basilar apex aneurysms implementing Hunterian ligation and extracranial-to-intracranial bypass: review of the literature with an illustrative case report.

World Neurosurg 2018 Dec 8. Epub 2018 Dec 8.

Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

Large, broad-based basilar artery (BA) apex aneurysms involving multiple arterial origins are complex lesions commonly not amenable to direct clipping or endovascular management. BA proximal (Hunterian) occlusion with extracranial-to-intracranial bypass is a supported strategy if one or both posterior communicating arteries are small. Hunterian ligation risks sudden aneurysm thrombosis and thromboembolism in the perforator rich BA apex. Read More

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December 2018

Sex differences in the temporal neuromolecular and synaptogenic effects of the rapid-acting antidepressant drug ketamine in the mouse brain.

Neuroscience 2018 Dec 8. Epub 2018 Dec 8.

Department of Biology & Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, Ohio, USA. Electronic address:

Preclinical evidence suggests that ketamine's rapid and sustained antidepressant actions are due to the induction of synaptogenesis in the medial prefrontal cortex (mPFC) and the hippocampus (HIPP), two brain regions implicated in the pathophysiology of major depression. However, research on the neurobiological effects of ketamine has focused almost exclusively on males. Findings from our group and others indicate that female rodents are more reactive to ketamine's antidepressant effects, since they respond to lower doses in antidepressant-predictive behavioral models. Read More

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December 2018

Mathematical analysis of a tumour-immune interaction model: A moving boundary problem.

Math Biosci 2018 Dec 8. Epub 2018 Dec 8.

Department of Mathematical Sciences, Stellenbosch University, Private Bag X1 Matieland, 7602, South Africa. Electronic address:

A spatio-temporal mathematical model, in the form of a moving boundary problem, to explain cancer dormancy is developed. Analysis of the model is carried out for both temporal and spatio-temporal cases. Stability analysis and numerical simulations of the temporal model replicate experimental observations of immune-induced tumour dormancy. Read More

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December 2018

Novel microbial community composition and carbon biogeochemistry emerge over time following saltwater intrusion in wetlands.

Glob Chang Biol 2018 Dec 9. Epub 2018 Dec 9.

Department of Biology, Trani Center for Life Sciences, Virginia Commonwealth University, Richmond, Virginia.

Sea level rise and changes in precipitation can cause saltwater intrusion into historically freshwater wetlands, leading to shifts in microbial metabolism that alter greenhouse gas emissions and soil carbon sequestration. Saltwater intrusion modifies soil physicochemistry and can immediately affect microbial metabolism, but further alterations to biogeochemical processing can occur over time as microbial communities adapt to the changed environmental conditions. To assess temporal changes in microbial community composition and biogeochemical activity due to saltwater intrusion, soil cores were transplanted from a tidal freshwater marsh to a downstream mesohaline marsh and periodically sampled over 1 year. Read More

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December 2018

Grey matter alterations in obesity: A meta-analysis of whole-brain studies.

Obes Rev 2018 Dec 10. Epub 2018 Dec 10.

Center of Mental Health, Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.

Obesity is a major problem in the modern world causing a higher risk for various cerebrovascular diseases causing a profound individual and societal burden. The neurobiological foundation bears potential to understand the complex interaction of individual differences in brain structure and function and ingestive behaviour. This systematic review was performed on the current evidence of structural abnormalities in grey matter volume (GMV) in patients with obesity based on studies published until December 2017, which were selected through search in PubMed, CENTER (Cochrane Library), PsycINFO, Web of Science, and Ovid MEDLINE. Read More

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December 2018
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Arachnoid cysts of the internal auditory canal: An underappreciated entity?

Laryngoscope 2018 Dec 8. Epub 2018 Dec 8.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U.S.A.

Objectives/hypothesis: To describe the histopathologic findings and clinical presentation of arachnoid cysts (ACs) within the human temporal bone.

Study Design: Retrospective cohort analysis.

Methods: An analysis of all medical records of patients diagnosed with an AC was performed. Read More

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December 2018

Oscillatory dynamics of cortical functional connections in semantic prediction.

Hum Brain Mapp 2018 Dec 7. Epub 2018 Dec 7.

MEG and Cortical Networks Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

An event related potential, known as the N400, has been particularly useful in investigating language processing as it serves as a neural index for semantic prediction. There are numerous studies on the functional segregation of N400 neural sources; however, the oscillatory dynamics of functional connections among the relevant sources has remained elusive. In this study we acquired magnetoencephalography data during a classic N400 paradigm, where the semantic predictability of a fixed target noun was manipulated in simple German sentences. Read More

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December 2018

Otopathology in Angiosarcoma of the Temporal Bone.

Laryngoscope 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts.

Objectives/hypothesis: Investigate the otopathology of angiosarcoma of the temporal bone, which has not been previously described in the literature.

Study Design: Postmortem evaluation and literature review.

Methods: Postmortem histological evaluation of the temporal bones and review of the literature for the treatment and prognosis of this rare disease were performed. Read More

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December 2018

Robust kidney perfusion mapping in pediatric chronic kidney disease using single-shot 3D-GRASE ASL with optimized retrospective motion correction.

Magn Reson Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Brain Repair and Rehabilitation, University College London Queen Square Institute of Neurology, Queen Square, London, United Kingdom.

Purpose: To develop a robust renal arterial spin labeling (ASL) acquisition and processing strategy for mapping renal blood flow (RBF) in a pediatric cohort with severe kidney disease.

Methods: A single-shot background-suppressed 3D gradient and spin-echo (GRASE) flow-sensitive alternating inversion recovery (FAIR) ASL acquisition method was used to perform 2 studies. First, an evaluation of the feasibility of single-shot 3D-GRASE and retrospective noise reduction methods was performed in healthy volunteers. Read More

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December 2018

EP and EP receptor antagonists: Impact on cytokine production and β -adrenergic receptor desensitization in human airway smooth muscle.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Woolcock Emphysema Centre, Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.

Prostaglandin E (PGE ) is a key prostanoid known to have both proinflammatory and anti-inflammatory impact in the context of chronic respiratory diseases. We hypothesize that these opposing effects may be the result of different prostanoid E (EP) receptor-mediated signaling pathways. In this study, we focus on two of the four EP receptors, EP and EP , as they are known to induce cyclic adenosine monophosphate (cAMP)-dependent signaling pathways. Read More

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December 2018

Rapid Assessment of Mitochondrial Complex I Activity and Metabolic Phenotyping of Breast Cancer Cells by NAD(p)H Cytometry.

Cytometry A 2018 Dec 11. Epub 2018 Dec 11.

Metabolic Photonics Laboratory, Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, California, 90048.

Cancer cells are known to display a variety of metabolic reprogramming strategies to fulfill their own growth and proliferative agenda. With the advent of high resolution imaging strategies, metabolomics techniques, and so forth, there is an increasing appreciation of critical role that tumor cell metabolism plays in the overall breast cancer (BC) growth. In this report, we demonstrate a sensitive, flow-cytometry-based assay for rapidly assessing the metabolic phenotypes in isolated suspensions of breast cancer cells. Read More

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December 2018

Altered spontaneous brain activity in classical trigeminal neuralgia as determined by changes in regional homogeneity: a resting-state functional MRI study.

Pain Pract 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center Nanchang 330006 Jiangxi, People's Republic of China.

Objective: Neuroimaging studies have reported that patients with pain-related conditions have altered neuronal activity and structural functions. The purpose of this study was to investigate whether classical trigeminal neuralgia (CTN) patients exhibit changes in corresponding neuronal activity via analysis of neuronal activity regional homogeneity (ReHo).

Methods: A total of 28 patients presenting with sore eyes (12 men and 16 women) were matched with 28 healthy controls (12 men and 16 women). Read More

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December 2018

Fire deficits have increased drought-sensitivity in dry conifer forests; fire frequency and tree-ring carbon isotope evidence from Central Oregon.

Glob Chang Biol 2018 Dec 9. Epub 2018 Dec 9.

Oregon State University, Forest Ecosystems and Society, 321 Richardson Hall, Corvallis, Oregon, United States, 97331-5752.

A century of fire suppression across the Western US has led to more crowded forests and increased competition for resources. Studies of forest thinning or stand conditions after mortality events have provided indirect evidence for how competition can promote drought stress and predispose forests to severe fire and/or bark beetle outbreaks. Here we demonstrate linkages between fire deficits and increasing drought stress through analyses of annually resolved tree-ring growth, fire scars, and carbon isotope discrimination (Δ C) across a dry mixed-conifer forest landscape. Read More

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December 2018

Multimodal magnetic resonance imaging investigation of basal forebrain damage and cognitive deficits in Parkinson's disease.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

Brain and Spine Institute - ICM, Center for NeuroImaging Research - CENIR, Paris, France.

Background: Cognitive deficits in Parkinson's disease (PD) may result from damage in the cortex as well as in the dopaminergic, noradrenergic, and cholinergic inputs to the cortex. Cholinergic inputs to the cortex mainly originate from the basal forebrain and are clustered in several regions, called Ch1 to Ch4, that project to the hippocampus (Ch1-2), the olfactory bulb (Ch3), and the cortex and amygdala (Ch4).

Objective: We investigated changes in basal forebrain and their role in cognitive deficits in PD. Read More

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December 2018

Novel features for capturing temporal variations of rhythmic limb movement to distinguish convulsive epileptic and psychogenic nonepileptic seizures.

Epilepsia 2018 Dec 9. Epub 2018 Dec 9.

Department of Electrical and Electronic Engineering, The University of Melbourne, Melbourne, Victoria, Australia.

Objective: To investigate the characteristics of motor manifestation during convulsive epileptic and psychogenic nonepileptic seizures (PNES), captured using a wrist-worn accelerometer (ACM) device. The main goal was to find quantitative ACM features that can differentiate between convulsive epileptic and convulsive PNES.

Methods: In this study, motor data were recorded using wrist-worn ACM-based devices. Read More

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December 2018

The temporomandibular joint: pneumatic temporal cells open into the articular and extradural spaces.

Folia Morphol (Warsz) 2018 Dec 11. Epub 2018 Dec 11.

The pneumatization of the articular tubercle (PAT) of the temporal squama is a rare condition that modifies the barrier between the temporomandibular joint (TMJ) space and the middle cranial fossa. During a routine examination of the cone beam computed tomography (CBCT) files of patients who were scanned for dental medical purposes, we identified a case with multiple rare anatomic variations. First, the petrous apex was bilaterally pneumatized. Read More

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December 2018

Brain activations associated with scientific reasoning: a literature review.

Cogn Process 2018 Dec 8. Epub 2018 Dec 8.

Laboratory for Research in Neuroeducation, Département de didactique, Université du Québec à Montréal, P.O. Box 8888, succursale Centre-Ville, Montreal, QC, H3C 3P8, Canada.

Scientifically literate individuals are defined as individuals who are able to apply scientific knowledge and use scientific reasoning skills to solve problems. In recent years, cognitive neuroscience has turned its attention to understanding the brain activation patterns associated with scientific reasoning skills, but this work has not been systematically reviewed for more than a decade. The present study reviews neuroimaging studies related to three types of scientific reasoning tasks: overcoming misconceptions, causal reasoning, and hypothesis generation. Read More

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December 2018

RECAPP-XPR: A smartphone application for presenting and recalling experimentally controlled stimuli over longer timescales.

Behav Res Methods 2018 Dec 10. Epub 2018 Dec 10.

Department of Psychology, University of Essex, Wivenhoe Park, Colchester, Essex, UK.

We report two experiments that used smartphone applications for presenting and recalling verbal stimuli over extended timescales. In Experiment 1, we used an iPhone application that we had developed, called RECAPP-XPR, to present 76 participants with a single list of eight words presented at a rate of one word every hour, followed by a test of free recall an hour later. The experiment was exceptionally easy to schedule, taking only between 5 and 10 min to set up using a web-based interface. Read More

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December 2018

Mercury Concentrations in Sentinel Fish Exposed to Contaminated Sediments Under a Natural Recovery Strategy Within the St. Lawrence River Area of Concern at Cornwall, Ontario, Canada.

Arch Environ Contam Toxicol 2018 Dec 7. Epub 2018 Dec 7.

St. Lawrence River Institute of Environmental Sciences, 2 St. Lawrence Drive, Cornwall, ON, K6H 4Z1, Canada.

Legacy mercury (Hg) sediment deposits are a long-term issue within the St. Lawrence River (Cornwall) area of concern with three depositional areas along the Cornwall, ON waterfront containing sediments that exceed the Ontario Sediment Quality Guidelines for Hg. Assessing the bioavailability of these Hg-contaminated sediments plays a crucial role in evaluating the effectiveness of the Cornwall Sediment Strategy based on a natural recovery approach. Read More

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December 2018

A SENtence Supramodal Areas AtlaS (SENSAAS) based on multiple task-induced activation mapping and graph analysis of intrinsic connectivity in 144 healthy right-handers.

Brain Struct Funct 2018 Dec 7. Epub 2018 Dec 7.

Univ. Bordeaux, IMN, UMR 5293, 33000, Bordeaux, France.

We herein propose an atlas of 32 sentence-related areas based on a 3-step method combining the analysis of activation and asymmetry during multiple language tasks with hierarchical clustering of resting-state connectivity and graph analyses. 144 healthy right-handers performed fMRI runs based on language production, reading and listening, both with sentences and lists of over-learned words. Sentence minus word-list BOLD contrast and left-minus-right BOLD asymmetry for each task were computed in pairs of homotopic regions of interest (hROIs) from the AICHA atlas. Read More

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December 2018

Does narrative drive dynamic attention to a prolonged stimulus?

Cogn Res Princ Implic 2018 Dec 7;3(1):45. Epub 2018 Dec 7.

School of Psychological Science, University of Bristol, Bristol, UK.

Attention in the "real world" fluctuates over time, but these fluctuations are hard to examine using a timed trial-based experimental paradigm. Here we use film to study attention. To achieve short-term engagement, filmmakers make use of low-level cinematic techniques such as color, movement and sound design to influence attention. Read More

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December 2018

The temporal relationship between cancer and adult onset anti-transcriptional intermediary factor 1 antibody-positive dermatomyositis.

Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.

Objectives: To characterize the 10 year relationship between anti-transcriptional intermediary factor 1 antibody (anti-TIF1-Ab) positivity and cancer onset in a large UK-based adult DM cohort.

Methods: Data from anti-TIF1-Ab-positive/-negative adults with verified diagnoses of DM from the UK Myositis Network register were analysed. Each patient was followed up until they developed cancer. Read More

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December 2018
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Context-Dependent Acoustic Signals in the Four-Eyed Fir Bark Beetle, Polygraphus proximus (Coleoptera: Curculionidae: Scolytinae).

Authors:
Ivan A Kerchev

Environ Entomol 2018 Dec 10. Epub 2018 Dec 10.

Institute of Monitoring of Climatic and Ecological Systems of the Siberian Branch of Russian Academy of Sciences, Tomsk, Russia.

Invasion of Polygraphus proximus (Blandford) has caused an extensive destruction in the aboriginal forest ecosystems of South Siberia. The goal of this study was to better understand the acoustic communication of P. proximus by analyzing the beetles' sound-production mechanisms and comparing sounds produced during different behaviors. Read More

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December 2018

Learning From Temporal Relationships: Childbirth and Breast Cancer Risk.

Ann Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Massachusetts General Hospital, Boston, Massachusetts (K.A.).

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December 2018

Spatial and Temporal Variation of the Blowflies Community (Diptera: Calliphoridae) From an Urban Area in Northern South America.

J Med Entomol 2018 Dec 6. Epub 2018 Dec 6.

Grupo de Investigación en Ciencias Forenses y Salud-GICFS, Tecnológico de Antioquia-Institución Universitaria, Medellín, Colombia.

Blowflies (Diptera: Calliphoridae) are necrophagous flies with ecological, medical, veterinary, and forensic importance. These flies carry pathogens that they spread to animals and humans, and produce myiasis. Furthermore, they are useful tools in forensic science as indicators of postmortem intervals, and in biomedicine they are successfully used in larval therapy. Read More

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December 2018

Beyond fixation durations: Recurrence quantification analysis reveals spatiotemporal dynamics of infant visual scanning.

J Vis 2018 Dec;18(13)

TALBY Study Team: Haiko Ballieux, Elena Kushnerenko, Mark. H. Johnson, Annette Karmiloff-Smith, Deirdre Birtles & Derek G. Moore.

Standard looking-duration measures in eye-tracking data provide only general quantitative indices, while details of the spatiotemporal structuring of fixation sequences are lost. To overcome this, various tools have been developed to measure the dynamics of fixations. However, these analyses are only useful when stimuli have high perceptual similarity and they require the previous definition of areas of interest (AOIs). Read More

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December 2018

WHAT ROLES FOR TRACK-STRUCTURE AND MICRODOSIMETRY IN THE ERA OF -omics AND SYSTEMS BIOLOGY?

Radiat Prot Dosimetry 2018 Dec 11. Epub 2018 Dec 11.

Physics Department, University of Pavia, Pavia, Italy.

Ionizing radiation is a peculiar perturbation when it comes to damage to biological systems: it proceeds through discrete energy depositions, over a short temporal scale and a spatial scale critical for subcellular targets as DNA, whose damage complexity determines the outcome of the exposure. This lies at the basis of the success of track structure (and nanodosimetry) and microdosimetry in radiation biology. However, such reductionist approaches cannot account for the complex network of interactions regulating the overall response of the system to radiation, particularly when effects are manifest at the supracellular level and involve long times. Read More

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December 2018

Primary Motor Cortex Transcranial Direct Current Stimulation Modulates Temporal Summation of the Nociceptive Withdrawal Reflex in Healthy Subjects.

Pain Med 2018 Dec 7. Epub 2018 Dec 7.

The Nick Davey Laboratory, Faculty of Medicine, Imperial College London, London, UK.

Objective: Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has shown efficacy in a number of chronic pain conditions. Despite attempts to dissect the analgesic mechanisms, it is unknown whether M1 tDCS modulates the central integration of spinal nociception. To test this, we investigated the top-down modulation of spinal excitability using temporal summation (TS) of the nociceptive withdrawal reflex (NWR). Read More

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December 2018

Temporally Unconstrained Decoding Reveals Consistent but Time-Varying Stages of Stimulus Processing.

Cereb Cortex 2018 Dec 7. Epub 2018 Dec 7.

Department of Psychiatry, Oxford Centre for Human Brain Activity (OHBA), University of Oxford, Oxford, UK.

In this article, we propose a method to track trial-specific neural dynamics of stimulus processing and decision making with high temporal precision. By applying this novel method to a perceptual template-matching task, we tracked representational brain states associated with the cascade of neural processing, from early sensory areas to higher order areas that are involved in integration and decision making. We address a major limitation of the traditional decoding approach: that it relies on consistent timing of these processes over trials. Read More

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December 2018

The Role of the Human Auditory Corticostriatal Network in Speech Learning.

Cereb Cortex 2018 Dec 7. Epub 2018 Dec 7.

Department of Communication Science and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA, USA.

We establish a mechanistic account of how the mature human brain functionally reorganizes to acquire and represent new speech sounds. Native speakers of English learned to categorize Mandarin lexical tone categories produced by multiple talkers using trial-by-trial feedback. We hypothesized that the corticostriatal system is a key intermediary in mediating temporal lobe plasticity and the acquisition of new speech categories in adulthood. Read More

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December 2018
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Lesions to the Fronto-Parietal Network Impact Alpha-Band Phase Synchrony and Cognitive Control.

Cereb Cortex 2018 Dec 7. Epub 2018 Dec 7.

Department of Psychology, Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.

Long-range phase synchrony in the α-oscillation band (near 10 Hz) has been proposed to facilitate information integration across anatomically segregated regions. Which areas may top-down regulate such cross-regional integration is largely unknown. We previously found that the moment-to-moment strength of high-α band (10-12 Hz) phase synchrony co-varies with activity in a fronto-parietal (FP) network. Read More

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December 2018

A COMPARISON BETWEEN X-RAY AND CARBON ION IRRADIATION IN HUMAN NEURAL STEM CELLS.

Radiat Prot Dosimetry 2018 Dec 11. Epub 2018 Dec 11.

Department of Physics, University of Pavia, via Bassi 6, Pavia, Italy.

Glioblastoma multiforme (GBM) is characterized by a poor prognosis and a median survival of ~12-18 months. GBM is usually managed by neurosurgery followed by both chemotherapy and radiotherapy. Since GBM develops resistance to conventional therapies, treatment with C-ions is promising to completely eradicate the tumoural mass. Read More

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December 2018

Association of author's financial conflict of interest with characteristics and outcome of rheumatoid arthritis randomized controlled trials.

Rheumatology (Oxford) 2018 Dec 10. Epub 2018 Dec 10.

Division of Rheumatology, Loma Linda University, Loma Linda, CA.

Objectives: To examine the prevalence, types and temporal trends of reported financial conflicts of interest (FCOIs) among authors of drug therapy randomized controlled trials (RCTs) for RA and their association with study outcomes.

Methods: We identified original, non-phase 1, parallel-group, drug therapy RA RCTs published in the years 2002-03, 2006-07, and 2010-11. Two investigators independently obtained trial characteristics data. Read More

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December 2018

[Temporal trend of hospital discharges due to infectious diseases in Chile, 2004-2014].

Rev Chilena Infectol 2018 Aug;35(4):358-362

Escuela de Salud Pública, Universidad Mayor, Santiago, Chile.

Background: Infectious diseases are important causes of burden of illness and mortality.

Aim: To describe the temporal trends of hospital discharges due to infectious in Chile from 2004 to 2014.

Methods: Descriptive study. Read More

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Single-cell analysis reveals individual spore responses to simulated space vacuum.

NPJ Microgravity 2018 4;4:26. Epub 2018 Dec 4.

1School of Electrical Engineering and Intelligentization, Dongguan University of Technology, Dongguan, Guangdong China.

Outer space is a challenging environment for all forms of life, and dormant spores of bacteria have been frequently used to study the survival of terrestrial life in a space journey. Previous work showed that outer space vacuum alone can kill bacterial spores. However, the responses and mechanisms of resistance of individual spores to space vacuum are unclear. Read More

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December 2018

Efficacy of a Bicistronic Vector for Correction of Sandhoff Disease in a Mouse Model.

Mol Ther Methods Clin Dev 2019 Mar 26;12:47-57. Epub 2018 Oct 26.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.

G gangliosidoses are a family of severe neurodegenerative disorders resulting from a deficiency in the β-hexosaminidase A enzyme. These disorders include Tay-Sachs disease and Sandhoff disease, caused by mutations in the gene and gene, respectively. The and genes are required to produce the α and β subunits of the β-hexosaminidase A enzyme, respectively. Read More

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March 2019
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Facial Malformation in Crouzon's Syndrome Is Consistent with Cranial Base Development in Time and Space.

Plast Reconstr Surg Glob Open 2018 Oct 1;6(10):e1963. Epub 2018 Oct 1.

Section of Plastic and Reconstructive Surgery, Yale School of Medicine, New Haven, Conn.

Background: In Crouzon's syndrome, cranial base deformities begin sequentially in the anterior cranial fossa initially, and later to the posterior cranial base. Facial characteristics are likely related to cranial base development. The temporal correlation between cranial base development and facial features is in need of clarification in Crouzon's patients, to clarify initial sites of deformity, which may impact surgical decision making. Read More

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October 2018

Complications in Brow Lifts: A Systemic Review of Surgical and Nonsurgical Brow Rejuvenations.

Plast Reconstr Surg Glob Open 2018 Oct 15;6(10):e1943. Epub 2018 Oct 15.

Dallas Plastic Surgery Institute, Dallas, Tex.

Background: Brow lift has been a part of plastic surgeons' armamentarium for over a century. Although there are multiple different techniques available, there has been a dearth of literature comparing which technique is better and has lesser complications. In this study, we performed a systemic literature review of all brow lift techniques to determine and compare complication rates of each technique. Read More

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October 2018

Blink Restoration in Long-standing Facial Paralysis: Use of Free Neurovascular Platysma Transfer.

Authors:
Paul J Guelinckx

Plast Reconstr Surg Glob Open 2018 Oct 22;6(10):e1939. Epub 2018 Oct 22.

Department of Plastic and Reconstructive Surgery, Jezza ZH, Hasselt, Belgium.

Background: Since 2004, microneurovascular platysma transfer has been used for dynamic eye closure in long-standing facial palsy. The idea was initially presented by Lee and Terzis in 1984 but abandoned owing to its transfer difficulty. This muscle transfer allows forceful closure and blink restoration. Read More

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October 2018
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Mouse optical imaging for understanding resting-state functional connectivity in human fMRI.

Commun Integr Biol 2018 21;11(4):e1528821. Epub 2018 Oct 21.

Department of Physiology, The University of Tokyo School of Medicine, Tokyo, Japan.

Resting-state functional connectivity (FC), which measures the temporal correlation of spontaneous hemodynamic activity between distant brain areas, is a widely accepted method in functional magnetic resonance imaging (fMRI) to assess the connectome of healthy and diseased human brains. A common assumption underlying FC is that it reflects the temporal structure of large-scale neuronal activity that is converted into large-scale hemodynamic activity. However, direct observation of such relationship has been difficult. Read More

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October 2018

Rifle Shooting Performance Correlates with Electroencephalogram Beta Rhythm Network Activity during Aiming.

Comput Intell Neurosci 2018 11;2018:4097561. Epub 2018 Nov 11.

School of Information Engineering and Automation, Kunming University of Science and Technology, Kunming, China.

To study the relationship between brain network and shooting performance during shooting aiming, we collected electroencephalogram (EEG) signals from 40 skilled shooters during rifle shooting and calculated the EEG functional coupling, functional brain network topology, and correlation coefficients between these EEG characteristics and shooting performance. Our result shows a significant negative correlation between shooting performance and functional coupling between the prefrontal, frontal, and temporal regions of the right brain in the Beta1 and Beta2 frequency bands. Global and local brain network topology characteristics were also significantly correlated with shooting performance. Read More

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November 2018

Radiobiological considerations in combining doses from external beam radiotherapy and brachytherapy for cervical cancer.

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):562-573. Epub 2018 Jul 2.

Unidad de Radiofísica, Hospital Universitario San Cecilio, E-18016 Granada, Spain.

The recommended radio-therapeutic treatment for cervix cancer consists of a first phase of external beam radiotherapy (EBRT) plus a second phase of brachytherapy (BT), the combined treatment being delivered within 8 weeks. In order to assess a comprehensive dosimetry of the whole treatment, it is necessary to take into account that these two phases are characterized by different spatial and temporal dosimetric distributions, which complicates the task of the summation of the two contributions, EBRT and BT. Radiobiology allows to tackle this issue pragmatically by means of the LQ model and, in fact, this is the usual tool currently in use for this matter. Read More

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July 2018
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Compatibility between object size and response side in grasping: the left hand prefers smaller objects, the right hand prefers larger objects.

PeerJ 2018 3;6:e6026. Epub 2018 Dec 3.

Institute of Psychology, TU Dortmund University, Dortmund, Germany.

It has been proposed that the brain processes quantities such as space, size, number, and other magnitudes using a common neural metric, and that this common representation system reflects a direct link to motor control, because the integration of spatial, temporal, and other quantity-related information is fundamental for sensorimotor transformation processes. In the present study, we examined compatibility effects between physical stimulus size and spatial (response) location during a sensorimotor task. Participants reached and grasped for a small or large object with either their non-dominant left or their dominant right hand. Read More

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December 2018

Inappropriate Laughter and Behaviours: How, What, and Why? Case of an Adult with Undiagnosed Gelastic Seizure with Hypothalamic Hamartoma.

Hawaii J Med Public Health 2018 Dec;77(12):319-324

John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (NLB,JCK,AS).

Gelastic seizures (GS) are a rare form of epilepsy characterized by inappropriate, uncontrolled laughter. They are highly associated with abnormal cognitive development and behavioral problems in patients. Research has shown that GS can originate from hypothalamic hamartomas (HH), non- neoplastic masses consisting of gray matter with large and small neurons interspersed with glial nuclei. Read More

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December 2018

Temporal Changes on the Risks and Complications of Posttransplantion Diabetes Mellitus Following Cardiac Transplantation.

J Transplant 2018 8;2018:9205083. Epub 2018 Nov 8.

Montreal Heart Institute, Université de Montréal, Montreal, QC, Canada.

Background: Recent changes in the demographic of cardiac donors and recipients have modulated the rate and risk, associated with posttransplant diabetes mellitus (PTDM). We investigated the secular trends of the risk of PTDM at 1 year and 3 years after transplantation over 30 years and explored its effect on major outcomes.

Methods: Three hundred and three nondiabetic patients were followed for a minimum of 36 months, after a first cardiac transplantation performed between 1983 and 2011. Read More

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November 2018

Anisakiasis in Italy: Analysis of hospital discharge records in the years 2005-2015.

PLoS One 2018 11;13(12):e0208772. Epub 2018 Dec 11.

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.

Background: Anisakiasis is a fish-borne zoonosis caused by the ingestion of marine food infected with Anisakis third-stage larvae, widespread marine parasitic nematodes. Gastrointestinal and/or allergic clinical signs and symptoms are not specific. While frequently reported in countries with large raw fish consumption as Japan, the global prevalence of anisakiasis may be severely underestimated due to limitations of available diagnostic tools and to diverse clinical manifestations. Read More

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December 2018

Understanding the reminiscence bump: A systematic review.

PLoS One 2018 11;13(12):e0208595. Epub 2018 Dec 11.

Department of Psychology, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya, Selangor, Malaysia.

One of the most consistently observed phenomena in autobiographical memory research is the reminiscence bump: a tendency for middle-aged and elderly people to access more personal memories from approximately 10-30 years of age. This systematic review (PROSPERO 2017:CRD42017076695) aimed to synthesize peer-reviewed literature pertaining to the reminiscence bump. The researchers conducted searches in nine databases for studies published between the date of inception of each database and the year 2017. Read More

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December 2018