1,128 results match your criteria Telogen Effluvium


Identification and molecular analysis of a lncRNA-HOTAIR transcript from secondary hair follicle of cashmere goat reveal integrated regulatory network with the expression regulated potentially by its promoter methylation.

Gene 2018 Dec 3. Epub 2018 Dec 3.

College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China. Electronic address:

The HOTAIR transcript is transcribed from the antisense strand within the HOXC gene cluster, and it is thought to play a role in regulating the inductive capacity of dermal papilla cells during the reconstruction of hair-follicle. In the current investigation, we firstly isolated and characterized a lncRNA-HOTAIR transcript from the secondary hair follicle of cashmere goat. Also, we analyzed its transcriptional pattern and methylation level of HOTAIR gene promoter in secondary hair follicle of cashmere goat during anagen and telogen stages. Read More

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December 2018
2 Reads
2.138 Impact Factor

Telogen Effluvium With Dysesthesia (TED) Has Lower B12 Levels and May Respond to B12 Supplementation

J Drugs Dermatol 2018 Nov;17(11):1236-1240

We investigated a subtype of Telogen Effluvium associated with Dysesthesia, (TED) which was defined as the presence of Telogen Effluvium with severe itch, pain, soreness, burning, or formication in the absence of any inflammatory scalp disorder or medication associated with Telogen Effluvium or Dysesthesia. These are patients who present with a “burning” scalp or other dysesthesia associated with increased telogen hair shedding. Telogen Effluvium is not typically associated with any scalp symptoms. Read More

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November 2018
2 Reads

Dynamic Nestin expression during hair follicle maturation and the normal hair cycle.

Mol Med Rep 2018 Nov 26. Epub 2018 Nov 26.

Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Guangzhou, Guangdong 510515, P.R. China.

Nestin, a type-VI intermediate filament protein, serves as a marker for neural stem cells, and is also known to be expressed in follicle stem cells. Hair follicles go through repeated cycles of anagen (growth), catagen (regression) and telogen (quiescence) throughout the life of mammals following morphogenesis. In the present study it was demonstrated that in mice, the maturation of hair follicles includes the period between morphogenesis and the first anagen (4 weeks of age). Read More

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November 2018

Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes.

J Photochem Photobiol B 2018 Dec 17;189:318-325. Epub 2018 Sep 17.

Merz Pharmaceuticals GmbH, Alfred-Wegener-Straße 2, 60438 Frankfurt, Germany. Electronic address:

Background: Ultraviolet radiation (UVR) is known to be harmful to normal human epidermal keratinocytes (NHEKs) of the epidermal skin layer, as well as to hair-follicle-associated keratinocytes. An oral formulation containing l-cystine, thiamin, calcium d-pantothenate, medicinal yeast, keratin and p-aminobenzoic acid (Panto[vi]gar®) has demonstrated clinical efficacy for the treatment of diffuse telogen effluvium; however, its mode of action at the cellular level, and in particular whether protective mechanisms are involved, has yet to be elucidated.

Objectives: To assess the capacity of ingredients of this oral formulation, both separately and in combination, to modulate the effects of UVR in growth-limited NHEKs in vitro. Read More

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December 2018
3 Reads

Fluconazole-Induced Alopecia: Examination in an animal model and human cohort.

Antimicrob Agents Chemother 2018 Nov 19. Epub 2018 Nov 19.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis.

Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair-cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms. Plasma and tissue levels of retinoic acid were not found causal. Read More

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November 2018
3 Reads

Alopecias in lupus erythematosus.

Lupus Sci Med 2018 25;5(1):e000291. Epub 2018 Oct 25.

Corporal Michael J Crescenz VAMC, Philadelphia, Pennsylvania, USA.

Several patterns of hair loss can occur in lupus erythematosus (LE). Alopecias which show histological characteristics of LE are LE-specific, and include discoid LE (DLE), diffuse or patchy hair loss in acute LE, subacute cutaneous LE, and rarely tumid LE. Lupus hair in SLE is a poorly characterised entity and may be a form of telogen effluvium. Read More

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October 2018
1 Read

HrQoL in hair loss-affected patients with alopecia areata, androgenetic alopecia and telogen effluvium: the role of personality traits and psychosocial anxiety.

J Eur Acad Dermatol Venereol 2018 Nov 5. Epub 2018 Nov 5.

Department of Experimental, Diagnostic and Speciality Medicine (DIMES), Alma Mater Studiorum Università di Bologna, Bologna, Italy.

Background: Illness impact on HrQoL has been widely studied in hair loss-affected patients, yet no study has addressed whether individual differences modulate HrQoL in patients with alopecia areata (AA), androgenetic alopecia (AGA) and telogen effluvium (TE).

Objective: To identify the personality dimensions most predictive of the impact of disease on HrQoL.

Method: A single-site cross-sectional study was carried out in the Dermatology Unit of Sant'Orsola-Malpighi Hospital, Bologna between September 2016 and September 2017. Read More

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November 2018
3 Reads

A liposome-based formulation containing equol, dihomo-γ-linolenic acid and propionyl-l-carnitine to prevent and treat hair loss: A prospective investigation.

Dermatol Ther 2018 Oct 29:e12778. Epub 2018 Oct 29.

Fidia Farmaceutici s.p.a., Abano Terme, Italy.

Hair loss is a common aesthetic disorder that can be triggered by genetic, inflammatory, hormonal, and environmental factors acting on hair follicles and their life cycle. There are several types of hair loss that differ in causes, symptoms, and spatial and temporal progression. Androgenic alopecia, a common form of hair loss, is the consequence of a decreased microcirculation of the scalp as well as the toxic action of elevated dihydrotestosterone levels on the hair bulbs. Read More

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October 2018

Transcriptomic analysis reveals critical genes for the hair follicle of Inner Mongolia cashmere goat from catagen to telogen.

PLoS One 2018 24;13(10):e0204404. Epub 2018 Oct 24.

College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.

There are two main types of hair follicle in Inner Mongolia Cashmere goats, the primary hair follicle (PHF) producing hair fibers and the secondary hair follicle (SHF) producing cashmere fibers. Of both fibers from cashmere-bearing goats in Aerbasi, Inner Mongolia, the timing of cyclical phases for the cashmere have been well clarified but hair fibers have been less noticeable. Herein, we evaluated transcriptome of PHF and SHF from the same three goats in Aerbasi at the catagen- and telogen phase of cashmere growth. Read More

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October 2018
6 Reads
3.230 Impact Factor

Effects of isotretinoin on the hair cycle.

J Cosmet Dermatol 2018 Oct 23. Epub 2018 Oct 23.

Department of Dermatology, Self-employed, Konya, Turkey.

Background/ Objectives: Isotretinoin is a synthetic vitamin A agent that affects all of the pathogenic factors that suppress sebum production and play a role in the formation of acne. It is frequently used in the treatment of moderate-severe acne vulgaris. However, there are some mucocutaneous and systemic side effects that limit the use of isotretinoin. Read More

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October 2018
1 Read

Sequential cyclic changes of hair roots revealed by dermoscopy demonstrate a progressive mechanism of diffuse alopecia areata over time.

Exp Dermatol 2018 Oct 11. Epub 2018 Oct 11.

Department of Dermatology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Background: Diffuse alopecia areata (DAA) often leads to a complete hair shedding within a few months.

Objective: To explore features and mechanisms underlying DAA.

Materials And Methods: Scalp and hair root dermoscopy were conducted on 23 DAA patients throughout the disease process, 20 patchy Alopecia areata patients, 23 acute telogen effluvium (ATE) patients and 10 normal controls. Read More

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October 2018
3 Reads

Proprietary Herbal Extract Downregulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Nonscarring Alopecia.

Med Arch 2018 Apr;72(2):136-140

Biota Laboratories, R&D Center, Sancaktepe, Istanbul, Turkey.

Background: Currently while, topical minoxidil and oral finasteride are the only medications approved in androgenetic alopecia (AGA), the cause oriented treatment and immunsupressive treatment are being performed in telogen effluvium (TE) and alopecia areata (AA) respectively. Considering the inflammatory factors in the pathogenesis of these three nonscarring alopecia forms, we have formulated a mixture for topical usage composed of six different herbal extracts (HE) which have already known antiinflammatory and antioxidant features.

Materials And Methods: In addition to performing the phytochemical analysis of HE, we detected the gene expression level of IL-1α, the crucial hair loss mediator, for the putative efficacy in nonscarring alopecia. Read More

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April 2018
2 Reads

Effect of tofacitinib on the expression of noggin/BMP-4 and hair growth stimulation in mice.

Arch Dermatol Res 2018 Dec 5;310(10):843-848. Epub 2018 Oct 5.

Chulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Klong Luang, Pathum Thani, 12120, Thailand.

Many hair loss disorders, including non-scaring alopecia, are caused by the arrest of hair follicles at the telogen phase, and the failure to enter the growth phase. Several studies report the efficacy of tofacitinib in promoting hair growth, by mechanisms not precisely known. The aim of this study was to identify other mechanisms by which tofacitinib, applied topically, promotes hair growth. Read More

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December 2018
1 Read

Telogen hair loss and androgenetic-like alopecia in GAPO syndrome.

Australas J Dermatol 2018 Sep 25. Epub 2018 Sep 25.

Department of Developmental Biology, Harvard School of Dental Medicine and Harvard Medical School, Boston, Massachusetts, USA.

Growth retardation, Alopecia, Pseudoanodontia and Optic atrophy (GAPO) syndrome is a rare autosomal recessive condition whose cardinal features include a recognizable craniofacial dysmorphosis, growth retardation, alopecia, pseudoanodontia, and premature aging. We report on a 2-year-old Pakistani man affected with GAPO syndrome who additionally shows an androgenetic-like alopecia with normal testosterone levels and telogen hair loss. These are novel findings in GAPO syndrome. Read More

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September 2018

The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat.

Sci Rep 2018 Sep 21;8(1):14227. Epub 2018 Sep 21.

College of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China.

It is widely accepted that the periodic cycle of hair follicles is controlled by the biological clock, but the molecular regulatory mechanisms of the hair follicle cycle have not been thoroughly studied. The secondary hair follicle of the cashmere goat is characterized by seasonal periodic changes throughout life. In the hair follicle cycle, the initiation of hair follicles is of great significance for hair follicle regeneration. Read More

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September 2018

Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.

Clin Cosmet Investig Dermatol 2018 10;11:431-436. Epub 2018 Sep 10.

Clinical Research, Farmoquímica S.A, Rio de Janeiro, Brazil.

Purpose: Telogen effluvium (TE) is defined as a diffuse hair loss characterized by shortening of the anagen phase and precipitation of the telogen phase, with a consequent reduction of total hair volume. Nutritional supplementation is indicated under conditions in which TE is related to dietary disorders. The aim of this clinical study was to compare the efficacy of two different supplements in monotherapy for TE. Read More

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September 2018
16 Reads

Temporary noncicatricial focal alopecia following Gamma knife radiosurgery: Case series and review of literature.

Neurol India 2018 Sep-Oct;66(5):1469-1474

Department of Radiotherapy, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objective: The aim of this study is to report the pattern, timing, responsible radiation parameters, and dosimetric results on the outcome of alopecia following gamma knife radiosurgery (GKRS) for various intracranial pathologies. A literature review of radiation-induced alopecia and observation of this complication with GKRS are also included.

Materials And Methods: The authors report 6 cases of GKRS-induced focal temporary alopecia without dermal fibrosis or clinical scarring and with no long-term squeal. Read More

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September 2018
1 Read

Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms.

Authors:
Bu Young Choi

Int J Mol Sci 2018 Sep 11;19(9). Epub 2018 Sep 11.

Department of Pharmaceutical Science and Engineering, Seowon University, Cheongju 28674, Korea.

The functional aspect of scalp hair is not only to protect from solar radiation and heat/cold exposure but also to contribute to one's appearance and personality. Progressive hair loss has a cosmetic and social impact. Hair undergoes three stages of hair cycle: the anagen, catagen, and telogen phases. Read More

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September 2018
1 Read

Thiosulfate promotes hair growth in mouse model.

Biosci Biotechnol Biochem 2019 Jan 10;83(1):114-122. Epub 2018 Sep 10.

a Laboratory for Molecular Psychiatry , RIKEN Center for Brain Science , Saitama , Japan.

The present study describes the hair growth-promoting effects of sodium thiosulfate (STS), a widely used compound, in mice. STS accelerated hair growth in the "telogen model", suggesting that it stimulates telogen hair follicles to reenter the anagen phase of hair growth. In the same model, STS potentiated hair growth in an additive manner with minoxidil (MXD), a drug used for the treatment of androgenic alopecia. Read More

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January 2019
1 Read

Efficacy and Safety of a Topical Botanical in Female Androgenetic Alopecia: A Randomized, Single-Blinded, Vehicle-Controlled Study.

Skin Appendage Disord 2018 Aug 16;4(3):160-165. Epub 2017 Nov 16.

2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens Medical School, "Attikon" General University Hospital, Athens, Greece.

Introduction: Androgenetic alopecia (AGA) in females is a difficult to treat skin disorder. A novel topical botanical lotion has been approved for its treatment. It acts by increasing Bcl-2, perifollicular Langerhans and mast cells, and perifollicular collagen. Read More

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August 2018
9 Reads

A unique case of pressure-induced alopecia following EEG monitoring.

Pediatr Dermatol 2018 Nov 6;35(6):e345-e347. Epub 2018 Sep 6.

Broward Health Medical Center, Fort Lauderdale, Florida.

We report a unique case of pressure-induced alopecia (PIA) in a 11-year-old boy following the use of electroencephalogram (EEG) electrodes on the scalp for 4 days. PIA is caused by localized ischemia leading to vascular congestion and discrete, often circumscribed patches of hair loss within 3-28 days of pressure interface. The synchronous conversion of follicles from anagen to catagen or telogen phase is the most distinctive finding of PIA. Read More

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November 2018
1 Read

Dengue Virus Infects Primary Human Hair Follicle Dermal Papilla Cells.

Front Cell Infect Microbiol 2018 21;8:268. Epub 2018 Aug 21.

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

During the epidemic of the dengue virus (DENV) infection in Taiwan in 2014 and 2015, we observed an abnormally high frequency of increased scalp hair shedding in infected individuals that could not be explained by telogen effluvium. In this study, the mechanism of hair loss caused by DENV was explored. Human hair follicle dermal papilla cells (HFDPCs) are essential for hair follicle morphogenesis and cycling. Read More

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Whole-genome bisulfite sequencing of goat skins identifies signatures associated with hair cycling.

BMC Genomics 2018 Aug 28;19(1):638. Epub 2018 Aug 28.

College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.

Background: Hair follicles (HFs), upon development, undergo repetitive cycles of growth (anagen), regression (catagen), and rest (telogen). The transition between the stages is determined by multiple molecular signals, including DNA methylation, which plays important roles in mammalian cellular identity and is essential for the development of HFs. Secondary hair follicles (SHFs) in cashmere goat exhibit classic cyclic hair development, and little has been done on a genome-wide scale to examine potentially methylated genes involved in the hair cyclic transition. Read More

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August 2018
1 Read
3.990 Impact Factor

Generation of trichogenic adipose-derived stem cells by expression of three factors.

J Dermatol Sci 2018 Oct 16;92(1):18-29. Epub 2018 Aug 16.

College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, South Korea; STEMORE Co. Ltd., Incheon, South Korea. Electronic address:

Background: Previous studies demonstrated that adipose-derived stem cells (ASCs) can promote hair growth, but unmet needs exist for enhancing ASC hair inductivity.

Objective: Therefore, we introduced three trichogenic factors platelet-derived growth factor-A, SOX2, and β-catenin to ASCs (tfASCs) and evaluated whether tfASCs have similar characteristics as dermal papilla (DP) cells.

Method: Global gene expression was examined using NGS analysis. Read More

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October 2018
9 Reads

Tight Junction barriers in human hair follicles - role of claudin-1.

Sci Rep 2018 Aug 24;8(1):12800. Epub 2018 Aug 24.

Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

Barrier function of hair follicles (HFs) is of great interest because they might be an entry port for allergens/pathogens, but could on the other hand be used for drug delivery or vaccination. Therefore we investigated tight junction (TJ) barrier function in human HFs. We show that there is a TJ barrier in the outermost living layer bordering to the environment from the infundibulum to the lower central part and between Henle's and Huxles layer of anagen HFs. Read More

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August 2018
3 Reads

The inconsistent regulation of HOXC13 on different keratins and the regulation mechanism on HOXC13 in cashmere goat (Capra hircus).

BMC Genomics 2018 Aug 23;19(1):630. Epub 2018 Aug 23.

College of Animal Science & Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Background: During hair growth, cortical cells emerging from the proliferative follicle bulb rapidly undergo a differentiation program and synthesize large amounts of hair keratin proteins. In this process, HOXC13 is one critical regulatory factor, proved by the hair defects in HOXC13 mutant mice and HOXC13 mutant patients. However, inconsistent conclusions were drawn from previous researches regarding the regulation of HOXC13 on different keratins. Read More

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August 2018
3 Reads

Scalp psoriasis with increased hair density.

Cutis 2018 Jul;102(1):63-64

Department of Dermatology, Kaiser Permanente Los Angeles Medical Center, California, USA.

Psoriasis is a chronic autoimmune skin disease that commonly affects the scalp. Psoriatic lesions on the scalp typically result in alopecia, possibly due to a higher proportion of hairs in the catagen and telogen stages. Involvement of the scalp in psoriasis can be problematic for the patient's quality of life as well as the clinician treating the condition. Read More

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July 2018
2 Reads

Decorin promotes proliferation and migration of ORS keratinocytes and maintains hair anagen in mice.

Exp Dermatol 2018 Nov 12;27(11):1237-1244. Epub 2018 Sep 12.

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

DECORIN is a prototypical member of the small leucine-rich proteoglycan (SLRP) family that plays important roles in numerous biological processes and cellular biological pathways. We previously showed that Decorin expression was highly enhanced in mouse dorsal hair follicles (HFs) during the anagen phase and was reduced during the catagen and telogen phases, suggesting that Decorin might modulate follicular cycling and morphogenesis. In this study, to further clarify the effects of DECORIN on hair cells and the cycling transition, an in vitro overexpression strategy and Decorin-null (Dcn ) mice were used to investigate the effects of DECORIN on outer root sheath (ORS) keratinocytes. Read More

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November 2018
1 Read

Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia.

Dermatol Surg 2018 10;44(10):1295-1303

Department of Pediatrics, Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: A new treatment for androgenetic alopecia (AGA) is a 1,550-nm erbium-glass (Er:Glass) fractional laser. The wound healing process associated with this treatment is believed to be due to the stimulation of hair regrowth. Both the Wingless-related integration site (Wnt) proteins and insulin-like growth factor 1 (IGF-1) are important molecules that promote new hair growth. Read More

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October 2018
8 Reads

White and yellow dots as new trichoscopic signs of severe female androgenetic alopecia in dark skin phototypes.

Int J Dermatol 2018 Oct 25;57(10):1221-1228. Epub 2018 Jul 25.

Department of Dermatology, Venereology and Andrology, Ain Shams University, Cairo, Egypt.

Background: Androgenetic alopecia or female pattern hair loss is the condition that most commonly leads to hair loss in adult females. The trichoscope is used for the early diagnosis of the disease. The study aims at finding a possible association between trichoscopic signs and disease severity in dark-skinned females. Read More

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October 2018
10 Reads

Hair and Scalp Changes in Cutaneous and Systemic Lupus Erythematosus.

Am J Clin Dermatol 2018 Oct;19(5):679-694

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.

Cutaneous and systemic lupus erythematosus (SLE) commonly involves the hair and scalp. Alopecia can result from direct activity of disease on the scalp or from the state of physical stress in the form of telogen effluvium. Discoid lupus erythematosus and lupus panniculitis/profundus are known to cause scarring alopecia, while accumulation of recent studies has shown that non-scarring alopecia in SLE may have different subtypes, comprising lupus erythematosus-specific and lupus erythematosus-nonspecific changes on histology. Read More

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October 2018
14 Reads

A proprietary herbal extract against hair loss in androgenetic alopecia and telogen effluvium: a placebo-controlled, single-blind, clinical-instrumental study.

Acta Dermatovenerol Alp Pannonica Adriat 2018 Jun;27(2):51-57

R&D Center, Sancaktepe, Biota Laboratories, Istanbul, Turkey.

Introduction: Currently there are only a limited number of drugs available for treatment of androgenetic alopecia and telogen effluvium. However, certain plants and their standardized extracts may provide some clinical benefits against hair loss. We formulated a herbal shampoo and a solution to evaluate their efficacy, safety, and synergy in hair loss. Read More

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June 2018
8 Reads

Assessment of Heavy Metal and Trace Element Levels in Patients with Telogen Effluvium.

Indian J Dermatol 2018 May-Jun;63(3):246-250

Medical Documentation and Secretary, Vocational School of Health Services, Yuzuncu Yil University, Tusba, Van, Turkey.

Background: Despite a multitude of studies, etiology of primary chronic telogen effluvium (TE) remains incompletely understood. Essential heavy metals are associated with beneficial effects in humans as well as in other living organisms. However, they may lead to toxic effects when the exposure exceeds the higher tolerable limits. Read More

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June 2018
1 Read

Expression and localization of VEGFR-2 in hair follicles during induced hair growth in mice.

Arch Dermatol Res 2018 Jun 16. Epub 2018 Jun 16.

Department of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou, 310009, China.

Recently, VEGFR-2 has been detected not only in vascular and lymphatic endothelial cells but also in some non-vascular endothelial cells, particularly human hair follicles, sebaceous glands, and sweat glands. In addition, VEGFR-2 has been confirmed to play direct roles in hair follicle keratinocyte regulation beyond simply angiogenesis. To elucidate whether VEGFR-2 activation plays a role in hair follicle cycling regulation, immunofluorescence of VEGFR-2 expression was performed during hair cycling of the dorsum of the mouse induced by hair plucking. Read More

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June 2018
2 Reads

The Follicle Cycle in Brief.

Adv Exp Med Biol 2018 ;1054:15-17

AgResearch Ltd., Lincoln, New Zealand.

This chapter presents a very succinct overview of the cyclic biology of the hair follicle as it transitions from the quiescent telogen stage to the anagen stage in which hairs are actively produced before regressing through the catagen stage to telogen. Read More

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January 2018

NonScarring Diffuse Hair Loss in Women: a Clinico-Etiological Study from tertiary care center in North-West India.

J Cosmet Dermatol 2018 May 17. Epub 2018 May 17.

Department of Dermatology, Venereology and Leprology, Government Medical College and Hospital, Chandigarh, India.

Background: Diffuse hair loss (DHL) is a common problem in adult women and has a major impact on quality of life. Ascertaining the etiological diagnosis is a challenging task in such patients. Satisfactory treatment can only be instituted after ascertaining the cause of hair loss. Read More

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May 2018
3 Reads

New multi-targeting strategy in hair growth promotion: in vitro and in vivo studies.

G Ital Dermatol Venereol 2018 Jun;153(3):338-343

International Hair Research Foundation, Milan, Italy -

Background: Considering the importance of hair in our modern society and the impact of hair loss, the efforts of researchers are addressed to better understand the mechanisms behind the hair cycle regulation and dysregulation. Because hair loss is multifactorial, differenced and new approaches are required. In particular we addressed our attention to two recently identified targets in hair cycling and growth control: olfactory receptor and autophagy. Read More

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June 2018
1 Read

iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice.

Biochem Biophys Res Commun 2018 07 18;501(4):893-897. Epub 2018 May 18.

Department of Geriatrics and Vascular Medicine, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.

Previous studies have shown that androgenic alopecia is associated with metabolic syndrome and diabetes. However, the detailed mechanism whereby diabetes causes alopecia still remains unclear. We focused on the inflammatory response that is caused by diabetes or obesity, given that inflammation is a risk factor for hair loss. Read More

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Coexistence of chronic cutaneous lupus erythematosus and frontal fibrosing alopecia.

An Bras Dermatol 2018 Mar;93(2):274-276

Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Lupus erythemathosus is a chronic, relapsing disease with acute, subacute, and chronic lesions. Effluvium telogen occurs in the setting of systemic activity of the disease, and cicatricial alopecia results from discoid lesionsin on the scalp. Other types of alopecia, like alopecia areata, may rarely be found in lupus. Read More

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March 2018
3 Reads

Vitamin D Status in Scarring and Non-Scarring Alopecia.

J Am Acad Dermatol 2018 Apr 21. Epub 2018 Apr 21.

Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH; Department of Dermatology, University of California Irvine, CA.

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Functional anatomy of the hair follicle: The Secondary Hair Germ.

Exp Dermatol 2018 Jul;27(7):701-720

Kurchatov complex of NBICS Technologies, National Research Center "Kurchatov Institute", Moscow, Russia.

The secondary hair germ (SHG)-a transitory structure in the lower portion of the mouse telogen hair follicle (HF)-is directly involved in anagen induction and eventual HF regrowth. Some crucial aspects of SHG functioning and ontogenetic relations with other HF parts, however, remain undefined. According to recent evidence (in contrast to previous bulge-centric views), the SHG is the primary target of anagen-inducing signalling and a source of both the outer root sheath (ORS) and ascending HF layers during the initial (morphogenetic) anagen subphase. Read More

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July 2018
4 Reads

Localized Telogen Effluvium Following Hair Transplantation.

Ann Dermatol 2018 Apr 21;30(2):214-217. Epub 2018 Feb 21.

Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.

Telogen effluvium is categorized in nonscarring alopecia, which shows scalp hair thinning and shedding diffusely resulting from inducing factors such as physiological stressful events and several acute or chronic diseases. It usually appears in female patients following parturition, as well as after febrile disease, major surgery, emotional stress, abrupt diet, chronic illness, or the taking of certain medication pills. Two patients who both recalled an operational history of hair transplantation visited our department with their frontal and both temporal hair loss. Read More

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April 2018
4 Reads

Short anagen syndrome: Case series and literature review.

Pediatr Dermatol 2018 May 26;35(3):388-391. Epub 2018 Mar 26.

Department of Dermatology and Cutaneous Surgery, Jackson Health System/Miller School of Medicine, University of Miami, Miami, FL, USA.

Background/objectives: Short anagen syndrome is a hair cycle disorder usually diagnosed in early childhood and characterized by short hair length due to short duration of the anagen phase. The objective was to review the presentation and demographic characteristics of short anagen syndrome and compare them with the most common differential diagnosis, loose anagen syndrome.

Methods: A retrospective review of eight children with short anagen syndrome was performed at the University of Miami Outpatient Dermatology Clinic. Read More

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May 2018
2 Reads

Color-transition sign: A useful trichoscopic finding for differentiating alopecia areata incognita from telogen effluvium.

J Dermatol 2018 Aug 6;45(8):e224-e225. Epub 2018 Mar 6.

Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.

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August 2018
9 Reads

Minoxidil Promotes Hair Growth through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells.

Int J Mol Sci 2018 Feb 28;19(3). Epub 2018 Feb 28.

College of Pharmacy, Yonsei University, Incheon 21983, Korea.

Minoxidil directly promotes hair growth via the stimulation of dermal papilla (DP) and epithelial cells. Alternatively, there is little evidence for indirect promotion of hair growth via stimulation of adipose-derived stem cells (ASCs). We investigated whether minoxidil stimulates ASCs and if increased growth factor secretion by ASCs facilitates minoxidil-induced hair growth. Read More

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February 2018

Telogen Effluvium: Is There a Need for a New Classification? A Reply.

Authors:
Alfredo Rebora

Skin Appendage Disord 2018 Jan 6;4(1):29-30. Epub 2017 Jul 6.

Clinica Dermatologica dell'Università, Genoa, Italy.

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January 2018
4 Reads

Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature.

Skin Appendage Disord 2018 Jan 24;4(1):1-11. Epub 2017 Jun 24.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

Androgenetic alopecia (AGA) is a hair loss disorder affecting 80% of men and 50% of women throughout their lifetime. Therapies for AGA are limited and there is no cure. There is a high demand for hair restoration. Read More

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January 2018
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Efficacy of 800 nm Diode Laser to Treat Trichostasis Spinulosa in Asian Patients.

Int J Trichology 2018 Jan-Feb;10(1):21-23

Clear Skin Clinic, Karad, Maharashtra, India.

Context: Trichostasis spinulosa (TS) is a common but underdiagnosed follicular disorder involving retention of successive telogen hair in the hair follicle. Laser hair removal is a newer treatment modality for TS with promising results.

Aims: This study aims to evaluate the efficacy of 800 nm diode laser to treat TS in Asian patients. Read More

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February 2018
12 Reads