198 results match your criteria Telangiectatic Osteosarcoma


Diaphyseal aneurysmal bone cysts (ABCs) of long bones in extremities: Analysis of surgical management and comparison with metaphyseal lesions.

J Clin Orthop Trauma 2021 Jul 17;18:74-79. Epub 2021 Apr 17.

Department of Pathology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, 124001, India.

Introduction: Aneurysmal bone cysts (ABCs) are benign lesions of long bone metaphysis affecting mostly medullary region in younger age below 20 years of life. These may be originated rarely either in the cortex or in the superficial regions of diaphysis. The study highlighted the differences of diaphyseal lesions from the usual metaphyseal ones in view of their clinical, radiological and biological behavior and also discussed their management in brief. Read More

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Analysis of a Preliminary microRNA Expression Signature in a Human Telangiectatic Osteogenic Sarcoma Cancer Cell Line.

Int J Mol Sci 2021 Jan 25;22(3). Epub 2021 Jan 25.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.

Telangiectatic osteosarcoma (TOS) is an aggressive variant of osteosarcoma (OS) with distinctive radiographic, gross, microscopic features, and prognostic implications. Despite several studies on OS, we are still far from understanding the molecular mechanisms of TOS. In recent years, many studies have demonstrated not only that microRNAs (miRNAs) are involved in OS tumorigenesis, development, and metastasis, but also that the presence in high-grade types of OS of cancer stem cells (CSCs) plays an important role in tumor progression. Read More

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January 2021

Iliac Telangiectatic Osteosarcoma - A Rare Presentation and Diagnostic Pitfall: A Case Report.

Malays Orthop J 2020 Nov;14(3):198-201

Department of Orthopaedics, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Telangiectatic osteosarcoma is a rare variant of osteosarcoma and can be easily misdiagnosed as aneurysmal bone cyst. We report an atypical case of iliac telangiectatic osteosarcoma in a young healthy female, who presents with painful slow growing expansile lytic septate lesion in the left hemipelvis, which is initially treated as aneurysmal bone cyst. The diagnosis of aneurysmal bone cyst is made after histopathological examination of core needle biopsy. Read More

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November 2020

Relationship Between Clinicopathological Features and Prognosis in Appendicular Osteosarcoma in Dogs.

J Comp Pathol 2020 Oct 6;180:91-99. Epub 2020 Oct 6.

Setor de Patologia Veterinária, Brazil.

Osteosarcoma is the most common primary bone neoplasm in dogs and often involves the appendicular skeleton. We report the clinicopathological and prognostic features of appendicular osteosarcomas diagnosed in 153 dogs from 2008 to 2018. The survival data for 22 dogs that underwent surgery and chemotherapy were statistically compared with the clinical, histopathological and immunohistochemical data for correlation with prognosis. Read More

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October 2020

KPNA2 expression is a potential marker for differential diagnosis between osteosarcomas and other malignant bone tumor mimics.

Diagn Pathol 2020 Nov 11;15(1):135. Epub 2020 Nov 11.

Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, 510632, Guangdong, China.

Background: Karyopherin α2 (KPNA2), a member of the karyopherin α family, has been studied in several cancers but has not yet been substantially investigated in malignant bone tumors. The purpose of the current study was to evaluate the KPNA2 expression level and its utility as a novel diagnostic biomarker in osteosarcomas and malignant bone tumor mimics, such as chondrosarcomas and Ewing sarcomas (ESs).

Method: We investigated the expression of KPNA2 protein by immunohistochemistry on paraffin-embedded surgical specimens from 223 patients with malignant and benign bone tumors, including 81 osteosarcomas, 42 chondrosarcomas, 15 ESs, 28 osteoid osteomas, 20 osteochondromas and 37 chondroblastomas. Read More

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November 2020

Fluid-fluid Levels in Musculoskeletal Tumor Imaging.

Curr Med Imaging 2021 ;17(2):157-165

First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Fluid-fluid levels result from the separation of two fluids of differing densities within a cavernous space with the boundary between the two layers running in a horizontal plane at 90 degrees to the direction of gravity. Magnetic resonance imaging is the most sensitive imaging modality to identify fluid-fluid levels. Although the most common bone lesions containing fluid-fluid levels are aneurysmal bone cyst and telangiectatic osteosarcoma, fluid-fluid levels can be observed in a wide variety of bone and soft tissue lesions. Read More

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January 2021

Aneurysmal bone cyst inadvertently treated with chemotherapy-A series of three cases.

Pediatr Blood Cancer 2020 10 6;67(10):e28638. Epub 2020 Aug 6.

Department of Orthopedics and Tumororthopedics, University Hospital Munster, Muenster, Germany.

Aneurysmal bone cyst (ABC) is a benign locally aggressive tumor that occurs in childhood and early adulthood. Most relevant differential diagnoses are the telangiectatic osteosarcoma and the giant cell tumor. In the present case series chemotherapy following the EURAMOS or the Euro-Ewing 99 protocol was externally applied in three patients with the misdiagnosis of ABC as malignant bone tumor. Read More

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October 2020

Primary breast telangiectatic osteosarcoma: a rare entity and a potential diagnostic pitfall.

Pathology 2020 08 29;52(5):601-603. Epub 2020 Jun 29.

Department of Pathology, Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

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Evaluation of factors affecting survival rate in primary bone sarcomas with extremity and pelvis involvement.

Acta Orthop Traumatol Turc 2020 May;54(3):234-244

Department of Orthopaedic Surgery and Traumatology, Marmara University, School of Medicine, İstanbul, Turkey.

Objective: This study is an evaluation of the overall survival rate and factors affecting survival in patients with osteosarcoma, chondrosarcoma, or Ewing's sarcoma. This study aimed to determine the effect of factors related to the preoperative period, patient, tumor, treatment, and postoperative period on survival.

Methods: A total of 114 patients (64 male and 50 female) with osteosarcoma, chondrosarcoma, or Ewing's sarcoma treated between 2005 and 2013 were included in this study. Read More

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The differentiation between aneurysmal bone cyst and telangiectatic osteosarcoma: a clinical, radiographic and MRI study.

Skeletal Radiol 2020 Sep 5;49(9):1375-1386. Epub 2020 Apr 5.

Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, HA7 4LP, UK.

Objectives: Aneurysmal bone cyst (ABC) and telangiectatic osteosarcoma (TOS) share several clinical and imaging features, including young presentation, long bone involvement, lytic appearance on radiography and fluid-fluid levels on MRI. Therefore, they may be difficult to differentiate. The aim of this study is to identify clinical, radiological and MRI features which aid differentiation of the two lesions. Read More

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September 2020

Validation of Fluorescence Hybridization Testing of Gene Rearrangement for Diagnosis of Primary Aneurysmal Bone Cyst.

Ann Clin Lab Sci 2019 Sep;49(5):590-597

Department of Pathology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing, China

Goals: Ubiquitin specific protease 6 () gene rearrangement has been reported in approximately 70%-75% of aneurysmal bone cyst cases. We hypothesize that fluorescence in situ hybridization (FISH) testing of this marker will be useful in the pathological differentiation of primary aneurysmal bone cyst (ABC), secondary ABC, giant cell tumor of bone (GCT), and telangiectatic osteosarcoma (TOS) which are morphologically similar. This study aims to evaluate the efficacy of this test and validate it for diagnostic use. Read More

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September 2019

Gain and loss from transcatheter intra-arterial limb infusion of cisplatin for extremity osteosarcoma: a retrospective study of 99 cases in the past six years.

Cancer Manag Res 2019 30;11:7183-7195. Epub 2019 Jul 30.

Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, People's Republic of China.

Purpose: We intend to analyze the gain and loss from transcatheter intra-arterial (IA) limb infusion of cisplatin for extremity osteosarcoma in the past six years.

Patients And Methods: Between December 2009 and August 2014, a total of 99 patients were analyzed for efficiency and followed up for long-term survival. Based on the different administration methods of cisplatin, we divided them into the following two cohorts: IA infusion of cisplatin (n=48) and intravenous (IV) infusion of cisplatin (n=51). Read More

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Aneurysmal Bone Cyst of the Distal Femoral Metaphysis in a Four-year-old Female Patient Presenting with a Pathologic Fracture: A Case Report.

Cureus 2019 Jun 6;11(6):e4846. Epub 2019 Jun 6.

Orthopedic Oncology, Sanford Medical Center, Fargo, USA.

Aneurysmal bone cysts (ABCs) are benign osteolytic vascular lesions that are capable of aggressive local expansion and bone destruction. These tumors are most common in adolescent patients and constitute approximately 9% of benign tumors. ABCs can present a diagnostic challenge, as they share several histological and radiographic characteristics with more aggressive lesions, including giant cell tumors and malignant telangiectatic osteosarcomas. Read More

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Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort.

Eur J Cancer 2019 03 25;109:36-50. Epub 2019 Jan 25.

CDC MRC Clinical Trials Unit at UCL, London, UK.

Background: High-grade osteosarcoma is a primary malignant bone tumour mainly affecting children and young adults. The European and American Osteosarcoma Study (EURAMOS)-1 is a collaboration of four study groups aiming to improve outcomes of this rare disease by facilitating randomised controlled trials.

Methods: Patients eligible for EURAMOS-1 were aged ≤40 years with M0 or M1 skeletal high-grade osteosarcoma in which case complete surgical resection at all sites was deemed to be possible. Read More

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Identification of probable telangiectatic osteosarcoma from a dog skull from multicultural settlement Polwica-Skrzypnik in Lower Silesia, Poland.

Int J Paleopathol 2019 03 20;24:299-307. Epub 2018 Aug 20.

Department of Animal Physiology and Biostructure, Division of Animal Anatomy, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Kożuchowska 1/3, 51-631 Wrocław, Poland. Electronic address:

This report presents canid cranial skeletal pathology from an excavation associated with the Przeworsk culture (III c. BC - V c. AD). Read More

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Primary appendicular hemangiosarcoma and telangiectatic osteosarcoma in 70 dogs: A Veterinary Society of Surgical Oncology retrospective study.

Vet Surg 2018 Aug 26;47(6):774-783. Epub 2018 Jul 26.

Fitzpatrick Referrals Oncology and Soft Tissue Ltd, Surrey, United Kingdom.

Objective: To define and compare clinical characteristics of canine primary appendicular hemangiosarcoma (HSA) and telangiectatic osteosarcoma (tOSA), including signalment, presentation, response to treatment, and prognosis.

Study Design: Multi-institutional retrospective study.

Animals: Seventy dogs with primary appendicular HSA or tOSA. Read More

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Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst.

J Bone Oncol 2018 Jun 26;11:10-16. Epub 2017 Nov 26.

Department of Orthopedic Oncology, First Affiliated Hospital of Sun Yat-Sen University, 58 Second Zhongshan Road, Guangzhou, Guangdong, China.

Background And Purpose: Telangiectatic osteosarcoma (TOS), a rare variant of osteosarcoma, may be easily misdiagnosed as aneurysmal bone cyst (ABC). The aims of this study were to investigate the diagnostic and prognostic factors of TOS by reviewing our experience with TOS and to develop a diagnostic model that may distinguish TOS from ABC.

Materials And Methods: We identified 51 cases of TOS treated at the First Affiliated Hospital of Sun Yat-Sen University from March 2001 to January 2016 and reviewed their records, imaging information and pathological studies. Read More

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Capillary Hemangioma as an Unusual Cause of Doughnut Sign on Bone Scan.

Clin Nucl Med 2018 Jul;43(7):499-501

Department of Radiology and Nuclear Medicine, University of Jordan, Amman, Jordan.

Abstracts: A 28-year-old woman presented with a mass in her right leg, which, on plain radiograph, appeared as a lytic lesion in the mid-shaft of the tibia with cortical thinning but without periosteal reaction. Tc-MDP 3-phase bone scan demonstrated intense uptake in the periphery of the mass with a photopenic center, the so-called doughnut sign. Histopathology revealed a capillary hemangioma. Read More

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Telangiectatic osteosarcoma and renal adenocarcinoma in an Oscar (Astronotus ocellatus, Agassiz): Diagnostic imaging and immunohistochemical study.

J Fish Dis 2018 Jul 23;41(7):1165-1172. Epub 2018 Mar 23.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

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Is Core Needle Biopsy Reliable in Differentiating Between Aggressive Benign and Malignant Radiolucent Bone Tumors?

Clin Orthop Relat Res 2018 03;476(3):568-577

V. Hegde, Z. D. C. Burke, H. Y. Park, S. D. Zoller, D. Johansen, B. V. Kelley, N. M. Bernthal, Department of Orthopaedic Surgery, University of California-Los Angeles, Santa Monica, CA, USA B. D Levine, K. Motamedi, L. L. Seeger, Department of Radiological Sciences, University of California-Los Angeles, Los Angeles, CA, USA N. C. Federman, Department of Pediatrics, University of California-Los Angeles, Los Angeles, CA, USA S. D. Nelson, Department of Pathology, University of California-Los Angeles, Santa Monica, CA, USA.

Background: Although there is widespread acceptance of core needle biopsy (CNB) for diagnosing solid tumors, there is reluctance by some clinicians to use CNB for aneurysmal bone cysts (ABCs) as a result of concerns of safety (bleeding, nerve injury, fracture, readmission, or infection) and reliability, particularly to rule out malignant diagnoses like telangiectatic osteosarcoma. This is especially true when CNB tissue is sent from an outside hospital, where the technique used to obtain the tissue may be spurious.

Questions/purposes: (1) Is CNB effective (provided adequate information to indicate appropriate surgical treatment without further open biopsy) as an initial diagnostic test for ABC? (2) Is CNB accurate (pathology consistent with the subsequent definitive surgical pathologic diagnosis) in differentiating between benign lesions such as primary or secondary ABCs and malignant radiolucent lesions such as telangiectatic osteosarcoma? (3) What are the complications of CNB? (4) Is there any difference in the effectiveness or accuracy of CNB performed at outside institutions when compared with a referral center?

Methods: A retrospective study of our musculoskeletal tumor board pathology database (1990-2016) was performed using search criteria "aneurysmal bone cyst" or "telangiectatic osteosarcoma. Read More

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Osteosarcoma subtypes: Magnetic resonance and quantitative diffusion weighted imaging criteria.

J Egypt Natl Canc Inst 2018 Mar 21;30(1):39-44. Epub 2018 Feb 21.

Department of Diagnostic and Interventional Radiology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Egypt.

Introduction: Osteosarcoma (OS) is a primary bone malignancy, characterized by spindle cells producing osteoid. The objective of this study is to describe the magnetic resonance imaging (MRI) features of different OS subtypes, record their attenuation diffusion coefficient (ADC) values and to point to the relation of their pathologic base and their corresponding ADC value.

Patients And Methods: We performed a retrospective observational lesion-based analysis for 31 pathologically proven osteosarcoma subtypes: osteoblastic (n = 9), fibroblastic (n = 8), chondroblastic (n = 6), para-osteal (n = 3), periosteal (n = 1), telangiectatic (n = 2), small cell (n = 1) and extra-skeletal (n = 1). Read More

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[Telangiectatic osteosarcoma in an infant].

Bol Med Hosp Infant Mex 2017 Jan - Feb;74(1):60-64. Epub 2017 Jan 24.

Hospital Roberto Gilbert, Guayaquil, Ecuador.

Background: Osteosarcoma is one of the most common types of cancer in childhood and adolescence and it is the most common malignant bone tumor in this group of age. Osteosarcoma is frequently found in long bones of the extremities. There are very few cases described in children under 5 years of age, and according to this review, none in infants. Read More

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OSTEOSARCOMA IN AFRICAN HEDGEHOGS (ATELERIX ALBIVENTRIS): FIVE CASES.

J Zoo Wildl Med 2017 Jun;48(2):453-460

Osteosarcomas are unusual neoplasms in African hedgehogs ( Atelerix albiventris ) and have been reported in extraskeletal and skeletal locations, including mandible, ribs, and vertebra. Five hedgehogs with osteosarcoma submitted to the Pathology Department at Facultad de Medicina Veterinaria y Zootecnia, National Autonomous University of Mexico are reported. In two cases, the neoplasm arose from the skull; one case arose from the ribs with associated compression of the thoracic and abdominal cavity, and another case involved the vertebrae. Read More

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Diagnosing and discriminating between primary and secondary aneurysmal bone cysts.

Oncol Lett 2017 Apr 7;13(4):2290-2296. Epub 2017 Feb 7.

Department of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.

Aneurysmal bone cysts (ABCs) are benign bony lesions frequently accompanied by multiple cystic lesions and aggressive bone destruction. They are relatively rare lesions, representing only 1% of bone tumors. The pathogenesis of ABCs has yet to be elucidated. Read More

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Central Telangiectatic Osteosarcoma of the Mandible in a Paediatric Patient: A Rarity.

J Clin Diagn Res 2016 Dec 1;10(12):XD01-XD03. Epub 2016 Dec 1.

Reader, Department of Pedodontics and Preventive Dentistry, SBB Dental College and Research Centre , Ghaziabad, Uttar Pradesh, India .

Osteosarcoma (OS) involving the head and neck region is rare and is a diagnostic challenge due to its aggressive nature and varied presentations. Although OS constitute 40% to 60% of all bone tumours, only 10% of these occur in the head and neck region, most commonly in the maxilla and mandible. OS of the jaw bone has a different pattern and behaviour when compared to OS at other anatomic location. Read More

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December 2016

Telangiectatic osteosarcoma of the rib: a rare entity and a potential diagnostic pitfall.

Pathologica 2016 Dec;108(4):175-178

Department of Pathology, Habib Bourguiba University Hospital, Sfax, Tunisia.

Osteosarcoma (OS) is a common primary malignant tumor of bones that produces osteoid matrix. Telangiectatic osteosarcoma (TOS) is a rare variant of OS. It affects the long bones especially the lower end of femur and the upper ends of tibia and humerus, a distribution similar to the conventional osteosarcoma. Read More

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December 2016

Spontaneous telangiectatic osteosarcoma in a rhesus macaque (Macaca mulatta).

J Med Primatol 2017 04 10;46(2):51-55. Epub 2017 Feb 10.

Serviço de criação de primatas não humanos, Instituto de Ciência e Tecnologia em Biomodelos (ICTB), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.

Osteosarcoma (OS) is the most common type of bone cancer, especially in young. Telangiectatic osteosarcoma (TO) is a rare variant of OS, and hence, its occurrence, presentation, and prognosis are poorly understood. A 4-year-old female rhesus monkey presenting lameness and swelling was examined for a mass on the right humerus. Read More

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Current management of aneurysmal bone cysts.

Curr Rev Musculoskelet Med 2016 Dec;9(4):435-444

Department of Orthopaedic Surgery, University of California, Los Angeles, 1250 16th St, Suite 2100, Santa Monica, CA, 90404, USA.

Aneurysmal bone cysts (ABCs) are benign bone lesions arising predominantly in the pediatric population that can cause local pain, swelling, and pathologic fracture. Primary lesions, which constitute roughly two thirds of all ABCs, are thought to be neoplastic in nature, with one third of ABCs arising secondary to other tumors. Diagnosis is made with various imaging modalities, which exhibit characteristic features such as "fluid-fluid levels," although biopsy is critical, as telangiectatic osteosarcoma cannot be excluded based on imaging alone. Read More

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December 2016