185 results match your criteria Telangiectatic Osteosarcoma


Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort.

Eur J Cancer 2019 Jan 24;109:36-50. Epub 2019 Jan 24.

COG Five Prime Therapeutics, Inc South San Francisco, CA, USA.

Background: High-grade osteosarcoma is a primary malignant bone tumour mainly affecting children and young adults. The European and American Osteosarcoma Study (EURAMOS)-1 is a collaboration of four study groups aiming to improve outcomes of this rare disease by facilitating randomised controlled trials.

Methods: Patients eligible for EURAMOS-1 were aged ≤40 years with M0 or M1 skeletal high-grade osteosarcoma in which case complete surgical resection at all sites was deemed to be possible. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.11.027DOI Listing
January 2019
5 Reads

Identification of probable telangiectatic osteosarcoma from a dog skull from multicultural settlement Polwica-Skrzypnik in Lower Silesia, Poland.

Int J Paleopathol 2019 Mar 20;24:299-307. Epub 2018 Aug 20.

Department of Animal Physiology and Biostructure, Division of Animal Anatomy, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Kożuchowska 1/3, 51-631 Wrocław, Poland. Electronic address:

This report presents canid cranial skeletal pathology from an excavation associated with the Przeworsk culture (III c. BC - V c. AD). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18799817173018
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http://dx.doi.org/10.1016/j.ijpp.2018.08.006DOI Listing
March 2019
22 Reads

Primary appendicular hemangiosarcoma and telangiectatic osteosarcoma in 70 dogs: A Veterinary Society of Surgical Oncology retrospective study.

Vet Surg 2018 Aug 26;47(6):774-783. Epub 2018 Jul 26.

Fitzpatrick Referrals Oncology and Soft Tissue Ltd, Surrey, United Kingdom.

Objective: To define and compare clinical characteristics of canine primary appendicular hemangiosarcoma (HSA) and telangiectatic osteosarcoma (tOSA), including signalment, presentation, response to treatment, and prognosis.

Study Design: Multi-institutional retrospective study.

Animals: Seventy dogs with primary appendicular HSA or tOSA. Read More

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http://doi.wiley.com/10.1111/vsu.12926
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http://dx.doi.org/10.1111/vsu.12926DOI Listing
August 2018
10 Reads
1.041 Impact Factor

Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst.

J Bone Oncol 2018 Jun 26;11:10-16. Epub 2017 Nov 26.

Department of Orthopedic Oncology, First Affiliated Hospital of Sun Yat-Sen University, 58 Second Zhongshan Road, Guangzhou, Guangdong, China.

Background And Purpose: Telangiectatic osteosarcoma (TOS), a rare variant of osteosarcoma, may be easily misdiagnosed as aneurysmal bone cyst (ABC). The aims of this study were to investigate the diagnostic and prognostic factors of TOS by reviewing our experience with TOS and to develop a diagnostic model that may distinguish TOS from ABC.

Materials And Methods: We identified 51 cases of TOS treated at the First Affiliated Hospital of Sun Yat-Sen University from March 2001 to January 2016 and reviewed their records, imaging information and pathological studies. Read More

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http://dx.doi.org/10.1016/j.jbo.2017.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993956PMC
June 2018
19 Reads

Capillary Hemangioma as an Unusual Cause of Doughnut Sign on Bone Scan.

Clin Nucl Med 2018 Jul;43(7):499-501

Department of Radiology and Nuclear Medicine, University of Jordan, Amman, Jordan.

Abstracts: A 28-year-old woman presented with a mass in her right leg, which, on plain radiograph, appeared as a lytic lesion in the mid-shaft of the tibia with cortical thinning but without periosteal reaction. Tc-MDP 3-phase bone scan demonstrated intense uptake in the periphery of the mass with a photopenic center, the so-called doughnut sign. Histopathology revealed a capillary hemangioma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002128DOI Listing
July 2018
22 Reads

Telangiectatic osteosarcoma and renal adenocarcinoma in an Oscar (Astronotus ocellatus, Agassiz): Diagnostic imaging and immunohistochemical study.

J Fish Dis 2018 Jul 23;41(7):1165-1172. Epub 2018 Mar 23.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

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http://dx.doi.org/10.1111/jfd.12788DOI Listing
July 2018
4 Reads

Is Core Needle Biopsy Reliable in Differentiating Between Aggressive Benign and Malignant Radiolucent Bone Tumors?

Clin Orthop Relat Res 2018 Mar;476(3):568-577

V. Hegde, Z. D. C. Burke, H. Y. Park, S. D. Zoller, D. Johansen, B. V. Kelley, N. M. Bernthal, Department of Orthopaedic Surgery, University of California-Los Angeles, Santa Monica, CA, USA B. D Levine, K. Motamedi, L. L. Seeger, Department of Radiological Sciences, University of California-Los Angeles, Los Angeles, CA, USA N. C. Federman, Department of Pediatrics, University of California-Los Angeles, Los Angeles, CA, USA S. D. Nelson, Department of Pathology, University of California-Los Angeles, Santa Monica, CA, USA.

Background: Although there is widespread acceptance of core needle biopsy (CNB) for diagnosing solid tumors, there is reluctance by some clinicians to use CNB for aneurysmal bone cysts (ABCs) as a result of concerns of safety (bleeding, nerve injury, fracture, readmission, or infection) and reliability, particularly to rule out malignant diagnoses like telangiectatic osteosarcoma. This is especially true when CNB tissue is sent from an outside hospital, where the technique used to obtain the tissue may be spurious.

Questions/purposes: (1) Is CNB effective (provided adequate information to indicate appropriate surgical treatment without further open biopsy) as an initial diagnostic test for ABC? (2) Is CNB accurate (pathology consistent with the subsequent definitive surgical pathologic diagnosis) in differentiating between benign lesions such as primary or secondary ABCs and malignant radiolucent lesions such as telangiectatic osteosarcoma? (3) What are the complications of CNB? (4) Is there any difference in the effectiveness or accuracy of CNB performed at outside institutions when compared with a referral center?

Methods: A retrospective study of our musculoskeletal tumor board pathology database (1990-2016) was performed using search criteria "aneurysmal bone cyst" or "telangiectatic osteosarcoma. Read More

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http://dx.doi.org/10.1007/s11999.0000000000000062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260019PMC
March 2018
14 Reads

Osteosarcoma subtypes: Magnetic resonance and quantitative diffusion weighted imaging criteria.

J Egypt Natl Canc Inst 2018 Mar 21;30(1):39-44. Epub 2018 Feb 21.

Department of Diagnostic and Interventional Radiology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Egypt.

Introduction: Osteosarcoma (OS) is a primary bone malignancy, characterized by spindle cells producing osteoid. The objective of this study is to describe the magnetic resonance imaging (MRI) features of different OS subtypes, record their attenuation diffusion coefficient (ADC) values and to point to the relation of their pathologic base and their corresponding ADC value.

Patients And Methods: We performed a retrospective observational lesion-based analysis for 31 pathologically proven osteosarcoma subtypes: osteoblastic (n = 9), fibroblastic (n = 8), chondroblastic (n = 6), para-osteal (n = 3), periosteal (n = 1), telangiectatic (n = 2), small cell (n = 1) and extra-skeletal (n = 1). Read More

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http://dx.doi.org/10.1016/j.jnci.2018.01.006DOI Listing
March 2018
2 Reads

[Telangiectatic osteosarcoma in an infant].

Bol Med Hosp Infant Mex 2017 Jan - Feb;74(1):60-64. Epub 2017 Jan 24.

Hospital Roberto Gilbert, Guayaquil, Ecuador.

Background: Osteosarcoma is one of the most common types of cancer in childhood and adolescence and it is the most common malignant bone tumor in this group of age. Osteosarcoma is frequently found in long bones of the extremities. There are very few cases described in children under 5 years of age, and according to this review, none in infants. Read More

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http://dx.doi.org/10.1016/j.bmhimx.2016.11.007DOI Listing
January 2017
5 Reads

OSTEOSARCOMA IN AFRICAN HEDGEHOGS (ATELERIX ALBIVENTRIS): FIVE CASES.

J Zoo Wildl Med 2017 Jun;48(2):453-460

Osteosarcomas are unusual neoplasms in African hedgehogs ( Atelerix albiventris ) and have been reported in extraskeletal and skeletal locations, including mandible, ribs, and vertebra. Five hedgehogs with osteosarcoma submitted to the Pathology Department at Facultad de Medicina Veterinaria y Zootecnia, National Autonomous University of Mexico are reported. In two cases, the neoplasm arose from the skull; one case arose from the ribs with associated compression of the thoracic and abdominal cavity, and another case involved the vertebrae. Read More

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http://dx.doi.org/10.1638/2016-0260R.1DOI Listing
June 2017
7 Reads

Diagnosing and discriminating between primary and secondary aneurysmal bone cysts.

Oncol Lett 2017 Apr 7;13(4):2290-2296. Epub 2017 Feb 7.

Department of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.

Aneurysmal bone cysts (ABCs) are benign bony lesions frequently accompanied by multiple cystic lesions and aggressive bone destruction. They are relatively rare lesions, representing only 1% of bone tumors. The pathogenesis of ABCs has yet to be elucidated. Read More

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http://dx.doi.org/10.3892/ol.2017.5682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403183PMC
April 2017
17 Reads

Central Telangiectatic Osteosarcoma of the Mandible in a Paediatric Patient: A Rarity.

J Clin Diagn Res 2016 Dec 1;10(12):XD01-XD03. Epub 2016 Dec 1.

Reader, Department of Pedodontics and Preventive Dentistry, SBB Dental College and Research Centre , Ghaziabad, Uttar Pradesh, India .

Osteosarcoma (OS) involving the head and neck region is rare and is a diagnostic challenge due to its aggressive nature and varied presentations. Although OS constitute 40% to 60% of all bone tumours, only 10% of these occur in the head and neck region, most commonly in the maxilla and mandible. OS of the jaw bone has a different pattern and behaviour when compared to OS at other anatomic location. Read More

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http://dx.doi.org/10.7860/JCDR/2016/24038.9066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296562PMC
December 2016
4 Reads

Telangiectatic osteosarcoma of the rib: a rare entity and a potential diagnostic pitfall.

Pathologica 2016 Dec;108(4):175-178

Department of Pathology, Habib Bourguiba University Hospital, Sfax, Tunisia.

Osteosarcoma (OS) is a common primary malignant tumor of bones that produces osteoid matrix. Telangiectatic osteosarcoma (TOS) is a rare variant of OS. It affects the long bones especially the lower end of femur and the upper ends of tibia and humerus, a distribution similar to the conventional osteosarcoma. Read More

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December 2016
28 Reads

Spontaneous telangiectatic osteosarcoma in a rhesus macaque (Macaca mulatta).

J Med Primatol 2017 04 10;46(2):51-55. Epub 2017 Feb 10.

Serviço de criação de primatas não humanos, Instituto de Ciência e Tecnologia em Biomodelos (ICTB), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.

Osteosarcoma (OS) is the most common type of bone cancer, especially in young. Telangiectatic osteosarcoma (TO) is a rare variant of OS, and hence, its occurrence, presentation, and prognosis are poorly understood. A 4-year-old female rhesus monkey presenting lameness and swelling was examined for a mass on the right humerus. Read More

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http://dx.doi.org/10.1111/jmp.12254DOI Listing
April 2017
11 Reads

Current management of aneurysmal bone cysts.

Curr Rev Musculoskelet Med 2016 Dec;9(4):435-444

Department of Orthopaedic Surgery, University of California, Los Angeles, 1250 16th St, Suite 2100, Santa Monica, CA, 90404, USA.

Aneurysmal bone cysts (ABCs) are benign bone lesions arising predominantly in the pediatric population that can cause local pain, swelling, and pathologic fracture. Primary lesions, which constitute roughly two thirds of all ABCs, are thought to be neoplastic in nature, with one third of ABCs arising secondary to other tumors. Diagnosis is made with various imaging modalities, which exhibit characteristic features such as "fluid-fluid levels," although biopsy is critical, as telangiectatic osteosarcoma cannot be excluded based on imaging alone. Read More

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http://dx.doi.org/10.1007/s12178-016-9371-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127951PMC
December 2016
8 Reads

Bayesian pretest probability estimation for primary malignant bone tumors based on the Surveillance, Epidemiology and End Results Program (SEER) database.

Int J Comput Assist Radiol Surg 2017 Mar 8;12(3):485-491. Epub 2016 Oct 8.

Department of Radiology, University Hospital Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany.

Purpose: In the diagnostic process of primary bone tumors, patient age, tumor localization and to a lesser extent sex affect the differential diagnosis. We therefore aim to develop a pretest probability calculator for primary malignant bone tumors based on population data taking these variables into account.

Methods: We access the SEER (Surveillance, Epidemiology and End Results Program of the National Cancer Institute, 2015 release) database and analyze data of all primary malignant bone tumors diagnosed between 1973 and 2012. Read More

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http://dx.doi.org/10.1007/s11548-016-1491-3DOI Listing
March 2017
10 Reads

Establishment and Characterization of a Human Small Cell Osteosarcoma Cancer Stem Cell Line: A New Possible In Vitro Model for Discovering Small Cell Osteosarcoma Biology.

Stem Cells Int 2016 29;2016:3042198. Epub 2016 Aug 29.

Department of Surgery and Translational Medicine (DCMT), University of Florence, 50134 Florence, Italy.

Osteosarcoma (OSA) is the most common primary malignant bone tumor, usually arising in the long bones of children and young adults. There are different subtypes of OSA, among which we find the conventional OS (also called medullary or central osteosarcoma) which has a high grade of malignancy and an incidence of 80%. There are different subtypes of high grade OS like chondroblastic, fibroblastic, osteoblastic, telangiectatic, and the small cell osteosarcoma (SCO). Read More

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http://dx.doi.org/10.1155/2016/3042198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019944PMC
September 2016
39 Reads

Use of routine histopathology and factor VIII-related antigen/von Willebrand factor immunohistochemistry to differentiate primary hemangiosarcoma of bone from telangiectatic osteosarcoma in 54 dogs.

Vet Comp Oncol 2017 Dec 9;15(4):1232-1239. Epub 2016 Aug 9.

KamPath Diagnostics and Investigation LLC, Fort Collins, CO, USA.

Hemangiosarcoma (HSA) of bone and telangiectatic osteosarcoma (tOSA) can appear similar histologically, but differ in histogenesis (malignant endothelial cells versus osteoblasts), and may warrant different treatments. Immunohistochemistry (IHC) for endothelial cell marker factor VIII-related antigen/von Willebrand factor (FVIII-RAg/vWF) is a well-documented ancillary test to confirm HSA diagnoses in soft tissues, but its use in osseous HSA is rarely described. Archived samples of 54 primary appendicular bone tumours previously diagnosed as HSA or tOSA were evaluated using combination routine histopathology (RHP) and IHC. Read More

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http://dx.doi.org/10.1111/vco.12259DOI Listing
December 2017
8 Reads

Telangiectatic osteosarcoma: a review of 87 cases.

J Cancer Res Clin Oncol 2016 Oct 28;142(10):2197-207. Epub 2016 Jul 28.

Department of Orthopedics and Orthopedic Oncology, University of Padova, Via Giustiniani, Padova, Italy.

Purposes: Telangiectatic osteosarcoma (TOS) is a rare subtype of osteosarcoma. We analyzed (1) oncologic outcome in a large homogeneous series and (2) the role of prognostic factors on prognosis, local recurrence and metastasis.

Methods: Eighty-seven patients (47 males, 54 %) were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s00432-016-2210-8DOI Listing
October 2016
5 Reads

Aneurysmal Bone Cyst: An Analysis of 38 Cases and Report of Four Unusual Surface Ones.

Arch Bone Jt Surg 2016 Apr;4(2):166-72

Department of Pathology and Laboratory Medicine, Shafa Yahyaeyan Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.

Aneurysmal bone cyst (ABC) is a benign expansile bone tumor, most commonly involving the medulla of long bones. ABC rarely arises within the cortex or in the subperiosteal region, radiographically mimicking other conditions, in particular surface osteosarcomathat is low-grade in nature and may go secondary ABC changes, and telangiectatic osteosarcoma. Both of these are sometimes mistaken microscopically for primary ABC. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852045PMC
April 2016
8 Reads

Giant cell rich osteosarcoma revisited-diagnostic criteria and histopathologic patterns, Ki67, CDK4, and MDM2 expression, changes in response to bisphosphonate and denosumab treatment.

Virchows Arch 2016 Jun 22;468(6):741-55. Epub 2016 Mar 22.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong, China.

Defining giant cell-rich osteosarcoma (GCRO) as "an osteosarcoma in which more than 50% of the tumor consists of numerous uniformly distributed osteoclastic giant cells amidst oval or spindle mononuclear cells embedded in a fibrovascular stroma," eight such cases identified among 265 cases of osteosarcoma were analysed. Their age ranges from 11 to 33 years, with peak incidence in the second decade and equal sex distribution. Seventy-five percent presented with pain, commonest in the knee, affecting the metaphysis. Read More

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http://link.springer.com/10.1007/s00428-016-1926-9
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http://dx.doi.org/10.1007/s00428-016-1926-9DOI Listing
June 2016
15 Reads

Metaplastic carcinoma of the breast with widespread telangiectatic form of osteosarcomatous differentiation.

Pathol Int 2016 Apr 9;66(4):236-8. Epub 2015 Dec 9.

Department of Pathology, Singapore General Hospital, Singapore.

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http://dx.doi.org/10.1111/pin.12370DOI Listing
April 2016
14 Reads

Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma.

Am J Surg Pathol 2015 Nov;39(11):1576-83

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Specific H3F3A driver mutations and IDH2 mutations were recently described in giant cell tumor of bone (GCTB) and H3F3B driver mutations in chondroblastoma; these may be helpful as a diagnostic tool for giant cell-containing tumors of the bone. Using Sanger sequencing, we determined the frequency of H3F3A, H3F3B, IDH1, and IDH2 mutations in GCTBs (n=60), chondroblastomas (n=12), and other giant cell-containing tumors (n=24), including aneurysmal bone cyst, chondromyxoid fibroma, and telangiectatic osteosarcoma. To find an easy applicable marker for H3F3A mutation status, H3K36 trimethylation and ATRX expression were correlated with H3F3A mutations. Read More

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http://pdfs.journals.lww.com/ajsp/2015/11000/Mutation_Analys
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PAS.0000000000000512DOI Listing
November 2015
45 Reads
10 Citations
5.145 Impact Factor

FROM ANEURYSMAL BONE CYST TO TELANGIECTATIC OSTEOSARCOMA WITH METASTASIS IN INGUINAL LYMPH NODES - CASE REPORT.

Med Pregl 2015 Mar-Apr;68(3-4):127-32

Introduction: Aneurysmal bone cyst is a benign bone lesion composed of blood filled cystic cavities lined by fibrous septa. Its malignant transformation of is a rare event.

Case Report: We report a case of a lesion in the second metatarsal bone in a 29-year-old male, presented as a slight swelling of the right foot. Read More

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August 2015
39 Reads

[Accuracy of different preoperative biopsy techniques in diagnosis of osteosarcomas and their value in prognostic evaluation].

Zhonghua Bing Li Xue Za Zhi 2015 May;44(5):315-9

E-mail:

Objective: To study the difference in pathologic diagnostic accuracy among different histologic subtypes of osteosarcoma and different methods of preoperative biopsy, and the influence of diagnostic accuracy on prognosis of osteosarcoma.

Methods: The preoperative biopsies, complete clinical, radiological and pathological data of 347 pathologically confirmed osteosarcomas were evaluated. According to the Pathological Diagnostic and Technical Specifications, the accuracy of preoperative biopsies was divided into 6 grades. Read More

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May 2015
10 Reads

Differential diagnostic value of "blue reticulated chondroid-like material" in aneurysmal bone cysts: a classic histopathologic analysis of 215 cases.

Am J Clin Pathol 2015 Jun;143(6):823-9

Orthopaedic Hospital, Los Angeles, CA.

Objectives: Our classic histopathologic study of aneurysmal bone cyst (ABC) revealed that "blue reticulated chondroid-like material" (BRC) is characteristic of ABC.

Methods: The light microscopic findings were retrospectively analyzed in 215 cases of ABC, including 101 primary and 114 secondary cases. In addition, 22 cases of telangiectatic osteosarcoma (TOS) were drawn from the same source and used as a control. Read More

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https://academic.oup.com/ajcp/article/143/6/823/1766579
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http://dx.doi.org/10.1309/AJCP33YDDJKFFTSVDOI Listing
June 2015
9 Reads

Prognostic factors and survival rate of osteosarcoma: A single-institution study.

Asia Pac J Clin Oncol 2017 Apr 13;13(2):e104-e110. Epub 2015 Apr 13.

Department of Orthopaedics, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Aim: Osteosarcoma is a highly malignant primary bone tumor. The study aim to evaluate the prognostic factors influencing the survival rate in our center.

Methods: This was a retrospective cohort study of all patients treated between January 2005 and December 2010. Read More

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http://dx.doi.org/10.1111/ajco.12346DOI Listing
April 2017
42 Reads
9 Citations
1.060 Impact Factor

Diversity of Histologic Patterns and Expression of Cytoskeletal Proteins in Canine Skeletal Osteosarcoma.

Vet Pathol 2015 Sep 13;52(5):977-84. Epub 2015 Mar 13.

Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan

Osteosarcoma (OS), the most common bone tumor, includes OS of the head (OSH) and appendicular OS (OSA). In dogs, it is classified into 6 histologic subtypes: osteoblastic, chondroblastic, fibroblastic, telangiectatic, giant cell, and poorly differentiated. This study investigated the significance of the histologic classification relevant to clinical outcome and the histologic and immunohistochemical relationships between pleomorphism and expression of cytoskeletal proteins in 60 cases each of OSH and OSA. Read More

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http://dx.doi.org/10.1177/0300985815574006DOI Listing
September 2015
6 Reads

Telangiectatic osteosarcoma affecting the mandible.

J Oral Maxillofac Pathol 2014 Sep;18(Suppl 1):S143-6

Department of Pathology, Kawdoor SadanandaHegde Medical Academy, Mangalore, Karnataka, India.

Osteosarcomas are relatively rare in jaws and maxillomandibular lesions in children are distinctly uncommon. Telengiactic osteosarcomas in jaws are still a very rare variant and till now just 3 cases are reported in English literature. Herein, we report the first case of telangiectatic osteosarcoma occurring in mandible in pediatric patient. Read More

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http://dx.doi.org/10.4103/0973-029X.141371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211225PMC
September 2014
2 Reads

Epiphyseal osteosarcoma revisited: four illustrative cases with unusual histopathology and literature review.

APMIS 2015 Jan 22;123(1):9-17. Epub 2014 Sep 22.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Shatin, Hong Kong.

Osteosarcomas arising in the epiphysis are extremely rare and easily missed in the diagnostic consideration of epiphyseal tumors. It is the purpose of this study to delineate the clinical pathological characteristics of 'epiphyseal osteosarcoma' under the definition of 'a solitary long bone osteosarcoma radiographically considered an epiphyseal tumor for which the main radiologic differential diagnosis would encompass giant cell tumor, chondroblastoma and clear cell chondrosarcoma'. Four such cases with unusual histopathology were retrieved among 110 cases of osteosarcoma. Read More

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http://doi.wiley.com/10.1111/apm.12300
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http://dx.doi.org/10.1111/apm.12300DOI Listing
January 2015
12 Reads

Time-trends on incidence and survival in a nationwide and unselected cohort of patients with skeletal osteosarcoma.

Acta Oncol 2015 Jan 24;54(1):25-33. Epub 2014 Jun 24.

Department of Oncology, Oslo University Hospital, Norwegian Radium Hospital , Oslo , Norway.

Background: This study describes time-trends on epidemiology, subtypes and histopathological entities of osteosarcoma (OS) in a nationwide and unselected cohort of OS patients in Norway between 1975 and 2009. Few nationwide studies are published, and we still have particularly limited knowledge regarding patients not included in clinical trials comprising about half of the OS population.

Method: Histologically verified skeletal OS for all subgroups were included, resulting in 473 eligible cases from a total of 702 evaluated patients. Read More

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http://www.tandfonline.com/doi/full/10.3109/0284186X.2014.92
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http://dx.doi.org/10.3109/0284186X.2014.923934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364276PMC
January 2015
18 Reads

[Secondary telangiectatic osteosarcoma of the left femur. A case presentation of an unusual course of disease].

Orthopade 2014 May;43(5):467-72

Klinik für Orthopädie, Unfall- und Plastische Chirurgie, Universitätsklinikum Leipzig, Liebigstr. 20, 04103, Leipzig, Deutschland.

Background: This article presents the unusual case of a 73-year-old male patient who was treated with primary interlocking nailing after a pathological femoral fracture.

Diagnostics: Despite comprehensive diagnostics including several biopsies, a tumor could not be detected. In 2008 when progressive cystic femoral destruction leading to loosening of the nail necessitated a partial femoral prosthesis, an osteosarcoma could first be diagnosed in the resected bone. Read More

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http://dx.doi.org/10.1007/s00132-014-2311-5DOI Listing
May 2014
6 Reads

Osteogenic tumors of bone.

Semin Diagn Pathol 2014 Jan 5;31(1):21-9. Epub 2014 Jan 5.

Division of Surgical Pathology & Cytopathology, University of Virginia Health System, Charlottesville, Virginia.

In this paper we provide an overview of benign and malignant osteogenic bone tumors. We describe the diagnostic features, radiographic findings, and pertinent ancillary studies needed to diagnose these bone-forming lesions. We begin with osteoid osteoma and osteoblastoma, which are histologically bland and eminently benign with rare possible exceptions. Read More

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http://dx.doi.org/10.1053/j.semdp.2014.01.001DOI Listing
January 2014
8 Reads

Preoperative easily misdiagnosed telangiectatic osteosarcoma: clinical-radiologic-pathologic correlations.

Cancer Imaging 2013 Dec 11;13(4):520-6. Epub 2013 Dec 11.

Department of Radiology, First Affiliated Hospital of Sun Yat-sen University, 510080 Guangzhou, China.

Purpose: To describe the clinical, imaging, and pathologic characteristics and diagnostic methods of telangiectatic osteosarcoma (TOS) for improving the diagnostic level.

Materials And Methods: The authors retrospectively reviewed patient demographics, serum alkaline phosphatase (AKP) levels, preoperative biopsy pathologic reports, pathologic materials, imaging findings, and treatment outcomes from 26 patients with TOS. Patient images from radiography (26 cases) and magnetic resonance (MR) imaging (22 cases) were evaluated by 3 authors in consensus for intrinsic characteristics. Read More

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864225/
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http://dx.doi.org/10.1102/1470-7330.2013.0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864225PMC
December 2013
4 Reads

Ulnar osteosarcoma in dogs: 30 cases (1992-2008).

J Am Vet Med Assoc 2013 Jul;243(1):96-101

Department of Surgery, Animal Medical Center, New York, NY 10065, USA.

Objective: To examine the biological behavior of ulnar osteosarcoma and evaluate predictors of survival time in dogs.

Design: Retrospective case series.

Animals: 30 dogs with primary ulnar osteosarcoma. Read More

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http://dx.doi.org/10.2460/javma.243.1.96DOI Listing
July 2013
10 Reads

Prognostic factors for teenage and adult patients with high-grade osteosarcoma: an analysis of 240 patients.

Med Oncol 2013 9;30(3):624. Epub 2013 Jun 9.

Department of Medical Oncology, Dr. A.Y.Ankara Oncology Training and Research Hospital, 13. Street No: 56, Yenimahalle, 06200 Ankara, Turkey.

The aim of this retrospective, multicenter study was to evaluate clinicopathological characteristics, prognostic factors and treatment outcomes of teenage and adult patients with high-grade osteosarcoma. A total of 240 osteosarcoma patients who were diagnosed and treated from March 1995 to September 2011 were analyzed. Median age was 20 years (range 13-74 years), and 153 patients (63. Read More

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http://dx.doi.org/10.1007/s12032-013-0624-6DOI Listing
April 2014
79 Reads

Telangiectatic osteosarcoma: a review of literature.

Onco Targets Ther 2013 28;6:593-602. Epub 2013 May 28.

Department of Orthopedic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Telangiectatic osteosarcoma is a rare variant of osteosarcoma and hence its occurrence, presentation, and prognosis are poorly understood. With advancements in technology and available treatment options, the scenario of its diagnosis, management, and outcome has changed. Chemotherapy with surgery was challenged previously, but has now been proved to be beneficial. Read More

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http://dx.doi.org/10.2147/OTT.S41351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671797PMC
June 2013
38 Reads

Osteotropic cancer diagnosis by an osteocalcin inspired molecular imaging mimetic.

Biochim Biophys Acta 2013 Oct 17;1830(10):4621-7. Epub 2013 May 17.

Department of Translational Imaging, Weill Medical College of Cornell University, Houston, TX 77030, USA.

Background: Although microcalcifications of hydroxyapatite can be found in both benign and malignant osteotropic tumors, they are mostly seen in proliferative lesions, including carcinoma. The aim of this present study is to develop a molecular imaging contrast agent for selective identification of hydroxyapatite calcification in human osteotropic tumor tissues ex vivo and in human osteosarcoma cells in vitro.

Methods: A bioinspired biomarker, hydroxyapatite binding peptide (HABP), was designed to mimic natural protein osteocalcin property in vivo. Read More

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http://dx.doi.org/10.1016/j.bbagen.2013.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810120PMC
October 2013
10 Reads

Pathology in practice. Telangiectatic osteosarcoma.

J Am Vet Med Assoc 2013 May;242(10):1355-7

Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66502, USA.

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http://dx.doi.org/10.2460/javma.242.10.1355DOI Listing
May 2013
1 Read

Telangiectatic osteosarcoma.

J Orthop Surg (Hong Kong) 2013 Apr;21(1):96-9

Department of Oncologic Orthopaedic Surgery, Hospital de Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain.

Purpose: To review records of 8 patients with telangiectatic osteosarcoma (TOS) and determine whether pathologic fractures correlate with recurrence and survival.

Methods: Records of 4 men and 4 women aged 17 to 44 (mean, 28) years treated for TOS were reviewed. RESULTS; Of the 8 patients, 4 developed a pathologic fracture and 4 did not. Read More

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http://dx.doi.org/10.1177/230949901302100124DOI Listing
April 2013
4 Reads

Spontaneous osteoblastic osteosarcoma in a Mongolian gerbil (Meriones unguiculatus).

Comp Med 2013 Feb;63(1):62-6

University Research Animal Resources, University of Georgia, Athens, Georgia, USA.

Spontaneous neoplasms in Mongolian gerbils have an incidence of 20% to 26.8%, but osteosarcomas occur at a much lower rate. Here we report a 1-y-old Mongolian gerbil with a spontaneous osteosarcoma at the level of the proximal tibia, with metastases to the pectoral muscles and lungs. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567378PMC
February 2013
3 Reads

Primary cutaneous osteosarcoma of the skin: a report of 2 cases with emphasis on the differential diagnoses.

Am J Dermatopathol 2013 Aug;35(6):e106-13

Instituto de Investigación Sanitaria De La Princesa, Madrid, Spain.

Dermal or subcutaneous involvement of extraskeletal osteosarcoma is uncommon, and primary cutaneous osteosarcoma of the skin is even rarer, with only few cases well characterized. The authors present 2 cases of this infrequent skin neoplasm. A 76-year-old woman with a nodule on left malar area and an 82-year-old man with a hard nodule on the right temple. Read More

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http://dx.doi.org/10.1097/DAD.0b013e31827f0a6fDOI Listing
August 2013
1 Read

[Telangiectatic osteosarcoma secondary to a liposclerosing myxofibrous tumor: a case report].

Ann Pathol 2012 Aug 21;32(4):259-62. Epub 2012 Jul 21.

Service d'anatomie pathologique et histologie-cytologie, CHU de Rangueil, 1, avenue du Professeur-Jean-Poulhès, TSA 50032, 31059 Toulouse cedex 9, France.

Malignant transformation of a fibrous dysplasia into an osteosarcoma is very rare. We report the case of an 84-year-old man with telangiectatic osteosarcoma of the upper femur arising in a previous fibrous dysplasia also known as liposclerosing myxofibrous tumor. The tumor was expressing the epithelial membrane antigen. Read More

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http://dx.doi.org/10.1016/j.annpat.2012.06.003DOI Listing
August 2012
6 Reads

Pathologic fracture does not influence local recurrence and survival in high-grade extremity osteosarcoma with adequate surgical margins.

J Surg Oncol 2012 Dec 27;106(7):820-5. Epub 2012 Jun 27.

Peking University People's Hospital, Musculoskeletal Tumor Center, Beijing, China.

Background And Objectives: The purpose of this study was to estimate the risk factors having relationships with pathologic fracture of osteosarcoma of extremities and to evaluate the role of limb salvage surgery in this group of patients.

Methods: We retrospectively analyzed 28 consecutive cases of pathologic fracture of primary high-grade localized osteosarcoma of extremities between June 1, 2001 and June 30, 2009. All patients underwent limb salvage surgery and neo-adjuvant chemotherapy. Read More

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http://dx.doi.org/10.1002/jso.23150DOI Listing
December 2012
10 Reads

Telangiectatic osteosarcoma.

Arch Pathol Lab Med 2012 May;136(5):572-6

Department of Pathology, University of Utah Health Sciences Center, 50 N Medical Dr, Salt Lake City, UT 84132, USA.

Osteosarcoma is one of the most common primary malignant bone tumors in children and adolescents. Telangiectatic osteosarcoma is an unusual variant of osteosarcoma, forming 3% to 10% of all osteosarcomas. Radiographically, these tumors appear as purely lytic destructive lesions located in the metaphyses of long bones. Read More

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http://www.archivesofpathology.org/doi/abs/10.5858/arpa.2011
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http://dx.doi.org/10.5858/arpa.2011-0204-RSDOI Listing
May 2012
4 Reads

Aneurysmal bone cyst.

J Am Acad Orthop Surg 2012 Apr;20(4):233-41

Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY, USA.

Aneurysmal bone cysts are rare skeletal tumors that most commonly occur in the first two decades of life. They primarily develop about the knee but may arise in any portion of the axial or appendicular skeleton. Pathogenesis of these tumors remains controversial and may be vascular, traumatic, or genetic. Read More

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http://dx.doi.org/10.5435/JAAOS-20-04-233DOI Listing
April 2012
4 Reads

Primary telangiectatic osteosarcoma of the cervical spine.

J Neurosurg Spine 2012 Apr 6;16(4):373-8. Epub 2012 Jan 6.

Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Telangiectatic osteosarcoma (TOS) is one of the 8 subtypes of osteosarcoma that infrequently affects the spine. The radiopathological features of TOS overlap with those of more benign entities, most commonly the aneurysmal bone cyst), and therefore is a significant diagnostic challenge. It is a rare but well-described entity in the thoracolumbar and sacral spine, and to the authors' knowledge has not been previously reported in the cervical spine. Read More

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http://dx.doi.org/10.3171/2011.12.SPINE111037DOI Listing
April 2012
38 Reads

Telangiectatic osteosarcoma: Pathological rarity and scintigraphic exclusivity.

Indian J Nucl Med 2012 Jan;27(1):63-4

Department of Nuclear Medicine and Orthopedics, Nizam's Institute of Medical Sciences (NIMS), Hyderabad, India.

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http://dx.doi.org/10.4103/0972-3919.108883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628270PMC
January 2012
3 Reads