206 results match your criteria Telangiectatic Osteosarcoma


Intracranial extraosseous dural-based Ewing's sarcoma with fluid-haematocrit levels: imaging findings of a rare tumour.

BMJ Case Rep 2022 Jun 14;15(6). Epub 2022 Jun 14.

Radiodiagnosis, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India.

Extraosseous dural-based primary Ewing's sarcoma of the central nervous system is a rare tumour posing a diagnostic challenge. On cross-sectional radiological imaging, the lesion has an extra-axial location with heterogeneous appearance. These lesions are usually multicystic with internal haemorrhage causing fluid-haematocrit levels. Read More

View Article and Full-Text PDF

Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours.

Virchows Arch 2022 May 25. Epub 2022 May 25.

Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

Non-ossifying fibroma (NOF) and central giant cell granuloma (CGCG) are both benign tumours of bone with overlapping morphology and similar mutations in the RAS/MAPK pathway. However, NOF is located in the long bones with regression after puberty in contrast to CGCG which is located in the jaw bones and does not regress spontaneously. We hypothesised that endocrine regulation by oestrogen plays a role in the spontaneous regression in NOF. Read More

View Article and Full-Text PDF

Telangiectatic Osteosarcoma in a Young Child - A Case Report and Review of the Literature.

J Orthop Case Rep 2021 Jun;11(6):72-75

Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Introduction: Osteosarcoma (OS) is one of the most common primary malignant bone tumors in children and adolescents. OS incidence varies significantly with age and peak incidence is in adolescent age group. Telangiectatic osteosarcoma (TOS) is an unusual variant of OS, forming 3-10% of all OSs. Read More

View Article and Full-Text PDF

Pediatric Osteosarcoma: Pearls and Pitfalls.

Semin Ultrasound CT MR 2022 Feb 15;43(1):97-114. Epub 2021 May 15.

Department of Radiology, Cincinnati Children's Hospital Medical Center, Dept. of Radiology, Cincinnati, OH. Electronic address:

Osteosarcoma is a malignant bone tumor most commonly presenting in children. It has a bimodal distribution with a peak incidence occurring during the ages of 10-14 years old and in adults greater than age 65. The first peak of osteosarcoma correlates with the increased proliferation of bone during the pubertal growth period. Read More

View Article and Full-Text PDF
February 2022

A Case of Telangiectatic Osteosarcoma in the Frontal Bone.

NMC Case Rep J 2021 5;8(1):159-165. Epub 2021 Jun 5.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Telangiectatic osteosarcoma (TOS) is a subtype of osteosarcoma. TOS in the elderly and TOS in the skull are very rare. Here, we report a case of TOS in the frontal bone of an elderly patient. Read More

View Article and Full-Text PDF

Purely lytic telangiectatic osteosarcoma: A rare case of a 3-year-old female patient.

Pediatr Neonatol 2022 01 3;63(1):101-102. Epub 2021 Sep 3.

Department of Orthopaedics, Zhenxiong People's Hospital, Zhaotong, Yunnan Province, China. Electronic address:

View Article and Full-Text PDF
January 2022

Characteristics and prognosis of telangiectatic osteosarcoma: a population-based study using the Surveillance, Epidemiology and End Results (SEER) database.

Ann Transl Med 2021 May;9(9):796

Department of Orthopaedic Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Telangiectatic osteosarcoma (TOS) is a rare type of osteosarcoma for which limited clinical data is available. Furthermore, the clinical characteristics and prognosis of TOS remain unclear.

Methods: A large population-based cohort analysis was conducted using the Surveillance, Epidemiology and End Results (SEER) registry. Read More

View Article and Full-Text PDF

Telangiectatic osteosarcoma arising in osteogenesis imperfecta.

Acta Reumatol Port 2021 Apr-Jun;46(2):171-176

Serviço de Ortopedia e Traumatologia, Centro Hospitalar Lisboa Norte, EPE; Hospital de Santa Maria.

We present the case of a 32-year-old man with a diagnosis of type-III osteogenesis imperfecta who developed a telangiectatic osteosarcoma in the proximal right tibia. An above-knee amputation was performed and after one-year follow-up, pulmonary metastatic lesions were detected on the thoracic CT scan. Palliative chemotherapy was proposed and to date the patient is still living and is under medical treatment. Read More

View Article and Full-Text PDF
November 2021

Diaphyseal aneurysmal bone cysts (ABCs) of long bones in extremities: Analysis of surgical management and comparison with metaphyseal lesions.

J Clin Orthop Trauma 2021 Jul 17;18:74-79. Epub 2021 Apr 17.

Department of Pathology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, 124001, India.

Introduction: Aneurysmal bone cysts (ABCs) are benign lesions of long bone metaphysis affecting mostly medullary region in younger age below 20 years of life. These may be originated rarely either in the cortex or in the superficial regions of diaphysis. The study highlighted the differences of diaphyseal lesions from the usual metaphyseal ones in view of their clinical, radiological and biological behavior and also discussed their management in brief. Read More

View Article and Full-Text PDF

Analysis of a Preliminary microRNA Expression Signature in a Human Telangiectatic Osteogenic Sarcoma Cancer Cell Line.

Int J Mol Sci 2021 Jan 25;22(3). Epub 2021 Jan 25.

Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.

Telangiectatic osteosarcoma (TOS) is an aggressive variant of osteosarcoma (OS) with distinctive radiographic, gross, microscopic features, and prognostic implications. Despite several studies on OS, we are still far from understanding the molecular mechanisms of TOS. In recent years, many studies have demonstrated not only that microRNAs (miRNAs) are involved in OS tumorigenesis, development, and metastasis, but also that the presence in high-grade types of OS of cancer stem cells (CSCs) plays an important role in tumor progression. Read More

View Article and Full-Text PDF
January 2021

Iliac Telangiectatic Osteosarcoma - A Rare Presentation and Diagnostic Pitfall: A Case Report.

Malays Orthop J 2020 Nov;14(3):198-201

Department of Orthopaedics, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Telangiectatic osteosarcoma is a rare variant of osteosarcoma and can be easily misdiagnosed as aneurysmal bone cyst. We report an atypical case of iliac telangiectatic osteosarcoma in a young healthy female, who presents with painful slow growing expansile lytic septate lesion in the left hemipelvis, which is initially treated as aneurysmal bone cyst. The diagnosis of aneurysmal bone cyst is made after histopathological examination of core needle biopsy. Read More

View Article and Full-Text PDF
November 2020

Relationship Between Clinicopathological Features and Prognosis in Appendicular Osteosarcoma in Dogs.

J Comp Pathol 2020 Oct 6;180:91-99. Epub 2020 Oct 6.

Setor de Patologia Veterinária, Brazil.

Osteosarcoma is the most common primary bone neoplasm in dogs and often involves the appendicular skeleton. We report the clinicopathological and prognostic features of appendicular osteosarcomas diagnosed in 153 dogs from 2008 to 2018. The survival data for 22 dogs that underwent surgery and chemotherapy were statistically compared with the clinical, histopathological and immunohistochemical data for correlation with prognosis. Read More

View Article and Full-Text PDF
October 2020

KPNA2 expression is a potential marker for differential diagnosis between osteosarcomas and other malignant bone tumor mimics.

Diagn Pathol 2020 Nov 11;15(1):135. Epub 2020 Nov 11.

Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, 510632, Guangdong, China.

Background: Karyopherin α2 (KPNA2), a member of the karyopherin α family, has been studied in several cancers but has not yet been substantially investigated in malignant bone tumors. The purpose of the current study was to evaluate the KPNA2 expression level and its utility as a novel diagnostic biomarker in osteosarcomas and malignant bone tumor mimics, such as chondrosarcomas and Ewing sarcomas (ESs).

Method: We investigated the expression of KPNA2 protein by immunohistochemistry on paraffin-embedded surgical specimens from 223 patients with malignant and benign bone tumors, including 81 osteosarcomas, 42 chondrosarcomas, 15 ESs, 28 osteoid osteomas, 20 osteochondromas and 37 chondroblastomas. Read More

View Article and Full-Text PDF
November 2020

Fluid-fluid Levels in Musculoskeletal Tumor Imaging.

Curr Med Imaging 2021 ;17(2):157-165

First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Fluid-fluid levels result from the separation of two fluids of differing densities within a cavernous space with the boundary between the two layers running in a horizontal plane at 90 degrees to the direction of gravity. Magnetic resonance imaging is the most sensitive imaging modality to identify fluid-fluid levels. Although the most common bone lesions containing fluid-fluid levels are aneurysmal bone cyst and telangiectatic osteosarcoma, fluid-fluid levels can be observed in a wide variety of bone and soft tissue lesions. Read More

View Article and Full-Text PDF
October 2021

Aneurysmal bone cyst inadvertently treated with chemotherapy-A series of three cases.

Pediatr Blood Cancer 2020 10 6;67(10):e28638. Epub 2020 Aug 6.

Department of Orthopedics and Tumororthopedics, University Hospital Munster, Muenster, Germany.

Aneurysmal bone cyst (ABC) is a benign locally aggressive tumor that occurs in childhood and early adulthood. Most relevant differential diagnoses are the telangiectatic osteosarcoma and the giant cell tumor. In the present case series chemotherapy following the EURAMOS or the Euro-Ewing 99 protocol was externally applied in three patients with the misdiagnosis of ABC as malignant bone tumor. Read More

View Article and Full-Text PDF
October 2020

Primary breast telangiectatic osteosarcoma: a rare entity and a potential diagnostic pitfall.

Pathology 2020 08 29;52(5):601-603. Epub 2020 Jun 29.

Department of Pathology, Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

View Article and Full-Text PDF

Evaluation of factors affecting survival rate in primary bone sarcomas with extremity and pelvis involvement.

Acta Orthop Traumatol Turc 2020 May;54(3):234-244

Department of Orthopaedic Surgery and Traumatology, Marmara University, School of Medicine, İstanbul, Turkey.

Objective: This study is an evaluation of the overall survival rate and factors affecting survival in patients with osteosarcoma, chondrosarcoma, or Ewing's sarcoma. This study aimed to determine the effect of factors related to the preoperative period, patient, tumor, treatment, and postoperative period on survival.

Methods: A total of 114 patients (64 male and 50 female) with osteosarcoma, chondrosarcoma, or Ewing's sarcoma treated between 2005 and 2013 were included in this study. Read More

View Article and Full-Text PDF

The differentiation between aneurysmal bone cyst and telangiectatic osteosarcoma: a clinical, radiographic and MRI study.

Skeletal Radiol 2020 Sep 5;49(9):1375-1386. Epub 2020 Apr 5.

Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, HA7 4LP, UK.

Objectives: Aneurysmal bone cyst (ABC) and telangiectatic osteosarcoma (TOS) share several clinical and imaging features, including young presentation, long bone involvement, lytic appearance on radiography and fluid-fluid levels on MRI. Therefore, they may be difficult to differentiate. The aim of this study is to identify clinical, radiological and MRI features which aid differentiation of the two lesions. Read More

View Article and Full-Text PDF
September 2020

Validation of Fluorescence Hybridization Testing of Gene Rearrangement for Diagnosis of Primary Aneurysmal Bone Cyst.

Ann Clin Lab Sci 2019 Sep;49(5):590-597

Department of Pathology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing, China

Goals: Ubiquitin specific protease 6 () gene rearrangement has been reported in approximately 70%-75% of aneurysmal bone cyst cases. We hypothesize that fluorescence in situ hybridization (FISH) testing of this marker will be useful in the pathological differentiation of primary aneurysmal bone cyst (ABC), secondary ABC, giant cell tumor of bone (GCT), and telangiectatic osteosarcoma (TOS) which are morphologically similar. This study aims to evaluate the efficacy of this test and validate it for diagnostic use. Read More

View Article and Full-Text PDF
September 2019

Gain and loss from transcatheter intra-arterial limb infusion of cisplatin for extremity osteosarcoma: a retrospective study of 99 cases in the past six years.

Cancer Manag Res 2019 30;11:7183-7195. Epub 2019 Jul 30.

Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, People's Republic of China.

Purpose: We intend to analyze the gain and loss from transcatheter intra-arterial (IA) limb infusion of cisplatin for extremity osteosarcoma in the past six years.

Patients And Methods: Between December 2009 and August 2014, a total of 99 patients were analyzed for efficiency and followed up for long-term survival. Based on the different administration methods of cisplatin, we divided them into the following two cohorts: IA infusion of cisplatin (n=48) and intravenous (IV) infusion of cisplatin (n=51). Read More

View Article and Full-Text PDF

Aneurysmal Bone Cyst of the Distal Femoral Metaphysis in a Four-year-old Female Patient Presenting with a Pathologic Fracture: A Case Report.

Cureus 2019 Jun 6;11(6):e4846. Epub 2019 Jun 6.

Orthopedic Oncology, Sanford Medical Center, Fargo, USA.

Aneurysmal bone cysts (ABCs) are benign osteolytic vascular lesions that are capable of aggressive local expansion and bone destruction. These tumors are most common in adolescent patients and constitute approximately 9% of benign tumors. ABCs can present a diagnostic challenge, as they share several histological and radiographic characteristics with more aggressive lesions, including giant cell tumors and malignant telangiectatic osteosarcomas. Read More

View Article and Full-Text PDF

Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort.

Eur J Cancer 2019 03 25;109:36-50. Epub 2019 Jan 25.

CDC MRC Clinical Trials Unit at UCL, London, UK.

Background: High-grade osteosarcoma is a primary malignant bone tumour mainly affecting children and young adults. The European and American Osteosarcoma Study (EURAMOS)-1 is a collaboration of four study groups aiming to improve outcomes of this rare disease by facilitating randomised controlled trials.

Methods: Patients eligible for EURAMOS-1 were aged ≤40 years with M0 or M1 skeletal high-grade osteosarcoma in which case complete surgical resection at all sites was deemed to be possible. Read More

View Article and Full-Text PDF

Identification of probable telangiectatic osteosarcoma from a dog skull from multicultural settlement Polwica-Skrzypnik in Lower Silesia, Poland.

Int J Paleopathol 2019 03 20;24:299-307. Epub 2018 Aug 20.

Department of Animal Physiology and Biostructure, Division of Animal Anatomy, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Kożuchowska 1/3, 51-631 Wrocław, Poland. Electronic address:

This report presents canid cranial skeletal pathology from an excavation associated with the Przeworsk culture (III c. BC - V c. AD). Read More

View Article and Full-Text PDF

Primary appendicular hemangiosarcoma and telangiectatic osteosarcoma in 70 dogs: A Veterinary Society of Surgical Oncology retrospective study.

Vet Surg 2018 Aug 26;47(6):774-783. Epub 2018 Jul 26.

Fitzpatrick Referrals Oncology and Soft Tissue Ltd, Surrey, United Kingdom.

Objective: To define and compare clinical characteristics of canine primary appendicular hemangiosarcoma (HSA) and telangiectatic osteosarcoma (tOSA), including signalment, presentation, response to treatment, and prognosis.

Study Design: Multi-institutional retrospective study.

Animals: Seventy dogs with primary appendicular HSA or tOSA. Read More

View Article and Full-Text PDF

Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst.

J Bone Oncol 2018 Jun 26;11:10-16. Epub 2017 Nov 26.

Department of Orthopedic Oncology, First Affiliated Hospital of Sun Yat-Sen University, 58 Second Zhongshan Road, Guangzhou, Guangdong, China.

Background And Purpose: Telangiectatic osteosarcoma (TOS), a rare variant of osteosarcoma, may be easily misdiagnosed as aneurysmal bone cyst (ABC). The aims of this study were to investigate the diagnostic and prognostic factors of TOS by reviewing our experience with TOS and to develop a diagnostic model that may distinguish TOS from ABC.

Materials And Methods: We identified 51 cases of TOS treated at the First Affiliated Hospital of Sun Yat-Sen University from March 2001 to January 2016 and reviewed their records, imaging information and pathological studies. Read More

View Article and Full-Text PDF

Capillary Hemangioma as an Unusual Cause of Doughnut Sign on Bone Scan.

Clin Nucl Med 2018 Jul;43(7):499-501

Department of Radiology and Nuclear Medicine, University of Jordan, Amman, Jordan.

Abstracts: A 28-year-old woman presented with a mass in her right leg, which, on plain radiograph, appeared as a lytic lesion in the mid-shaft of the tibia with cortical thinning but without periosteal reaction. Tc-MDP 3-phase bone scan demonstrated intense uptake in the periphery of the mass with a photopenic center, the so-called doughnut sign. Histopathology revealed a capillary hemangioma. Read More

View Article and Full-Text PDF

Telangiectatic osteosarcoma and renal adenocarcinoma in an Oscar (Astronotus ocellatus, Agassiz): Diagnostic imaging and immunohistochemical study.

J Fish Dis 2018 Jul 23;41(7):1165-1172. Epub 2018 Mar 23.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

View Article and Full-Text PDF

Is Core Needle Biopsy Reliable in Differentiating Between Aggressive Benign and Malignant Radiolucent Bone Tumors?

Clin Orthop Relat Res 2018 03;476(3):568-577

V. Hegde, Z. D. C. Burke, H. Y. Park, S. D. Zoller, D. Johansen, B. V. Kelley, N. M. Bernthal, Department of Orthopaedic Surgery, University of California-Los Angeles, Santa Monica, CA, USA B. D Levine, K. Motamedi, L. L. Seeger, Department of Radiological Sciences, University of California-Los Angeles, Los Angeles, CA, USA N. C. Federman, Department of Pediatrics, University of California-Los Angeles, Los Angeles, CA, USA S. D. Nelson, Department of Pathology, University of California-Los Angeles, Santa Monica, CA, USA.

Background: Although there is widespread acceptance of core needle biopsy (CNB) for diagnosing solid tumors, there is reluctance by some clinicians to use CNB for aneurysmal bone cysts (ABCs) as a result of concerns of safety (bleeding, nerve injury, fracture, readmission, or infection) and reliability, particularly to rule out malignant diagnoses like telangiectatic osteosarcoma. This is especially true when CNB tissue is sent from an outside hospital, where the technique used to obtain the tissue may be spurious.

Questions/purposes: (1) Is CNB effective (provided adequate information to indicate appropriate surgical treatment without further open biopsy) as an initial diagnostic test for ABC? (2) Is CNB accurate (pathology consistent with the subsequent definitive surgical pathologic diagnosis) in differentiating between benign lesions such as primary or secondary ABCs and malignant radiolucent lesions such as telangiectatic osteosarcoma? (3) What are the complications of CNB? (4) Is there any difference in the effectiveness or accuracy of CNB performed at outside institutions when compared with a referral center?

Methods: A retrospective study of our musculoskeletal tumor board pathology database (1990-2016) was performed using search criteria "aneurysmal bone cyst" or "telangiectatic osteosarcoma. Read More

View Article and Full-Text PDF