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BJU Int 2018 Nov 15. Epub 2018 Nov 15.

Department of Urology, Guy's at St Thomas' Hospitals, London, UK.

Introduction: Systematic transperineal (TP) and targeted prostate biopsies can be achieved using a freehand access system through perineal punctures, with the potential for reduced morbidity and enabling the procedure under local anesthesia (LA), particularly sepsis.

Objectives: To evaluate the histopathological outcomes, morbidity and tolerability of freehand TP prostate biopsies using the PrecisionPoint access system under local anaesthetic (LA) in the day surgery and outpatient environments.

Methods: 176 patients underwent freehand TP prostate biopsies from May 2016 to November 2017. Read More

Zhonghua Nan Ke Xue 2018 May;24(5):393-398

Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.

Objective: To evaluate the analgesic effect of intrarectal local anesthesia (IRLA) versus that of periprostatic nerve block anesthesia (PPNB) in initial transrectal ultrasound-guided prostate biopsy (TRUS-PB) for patients with different prostate volumes (PV).

Methods: A total of 253 patients undergoing initial TRUS-PB in our hospital from January 2014 to November 2017 were divided into three PV groups (<50 ml, 50－100 ml, and >100 ml), each again randomized into three subgroups (control, IRLA, and PPNB) with the random number table method. The pain during the procedure was assessed based on the Visual Analogue Scale (VAS) scores and the blind method was used by the biopsy operator, VAS valuator and data analyst. Read More

Urol Oncol 2018 09 6;36(9):401.e1-401.e9. Epub 2018 Aug 6.

Department of Urology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

Objectives: Magnetic resonance imaging/transrectal ultrasound (MRI/TRUS) fusion-guided focal high intensity focused ultrasound (HIFU) therapy of the prostate has recently been developed as a selective HIFU-therapy technique to enable targeted ablation of prostate cancer. Here we report a series of patients treated with focal HIFU therapy, discuss its potential pitfalls, and address controversies concerning the indications.

Materials And Methods: This single-center prospective study reports outcomes of patients treated from September 2014 to March 2016. Read More

Prostate Cancer Prostatic Dis 2018 11 9;21(4):524-532. Epub 2018 Jul 9.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: The cornerstone of prostate cancer diagnosis remains the transrectal ultrasound-guided biopsy (TRUS-BX), which most frequently occurs in the office setting under local anesthesia. However, there are now other techniques of prostate biopsy aimed at improving outcomes such as patient comfort, significant cancer detection, and infectious complications. The purpose of the present study is to compare the cost and efficacy outcomes of five different approaches. Read More

Cent European J Urol 2018 8;71(1):38-42. Epub 2017 Jan 8.

Department of Urology, Hisar Intercontinental Hospital, Istanbul, Turkey.

Introduction: The objective of this study is to make a comparison between the effectiveness of the diclo- fenac suppository alone and periprostatic local anaesthesia infiltration alone to reduce the pain during a transrectal ultrasound-guided prostate biopsy procedure.

Material And Methods: Between January 2014 and December 2015, 100 patients from two centres who were scheduled for transrectal ultrasound guided prostate biopsy (TRUS Bx) were included in the study. Patients were divided into two groups; diclofenac suppository group (Group 1) and Lidocaine group (Group 2). Read More

Minerva Urol Nefrol 2018 Jun 28;70(3):264-274. Epub 2018 Mar 28.

Unit of Urology, Città di Castello Hospital, ASL Umbria 1, Città di Castello, Perugia, Italy.

Introduction: Prostate cancer (PCa) is a singular disease owing to absence of imaging technique able to detect suspicious glandular area at higher risk of disease. Nowadays, magnetic resonance imaging (MRI) has been used as a way to detect PCa and simplify targeting prostate biopsy (PB). The aim of this study is to review the most recent data regarding standard BP and MRI-guided PB. Read More

J Res Med Sci 2018 20;23:17. Epub 2018 Feb 20.

Department of Urology, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: We aim to compare the degree of pain control and complications in three types of anesthesia using periprostatic nerve block (PPNB) plus intrarectal local anesthesia (IRLA), low-dose spinal anesthesia, and intravenous (IV) sedation in patients undergoing transrectal ultrasound (TRUS)-guided prostate biopsy.

Materials And Methods: In this clinical trial study, 106 patients were participated from December 2015 to December 2016 at Alzahra Hospital, Isfahan, Iran. Patients were randomly allocated into three groups to receive PPNB plus IRLA ( = 36), low-dose spinal anesthesia ( = 35) and IV sedation ( = 35) before TRUS-guided prostate biopsy. Read More

Saudi J Anaesth 2018 Jan-Mar;12(1):16-21

Department of Urology, Faculty of Medicine, Assiut University Hospital, Assiut University, Assiut, Egypt.

Background: Transrectal ultrasound-guided prostate biopsy (TRUSPB) is considered the procedure of choice for the diagnosis of prostate cancer. Men undergoing this biopsy experience high psychological stress. Different studies recommend techniques as sedation, lidocaine gel intrarectally, periprostatic nerve block alone, or nitrous oxide inhalation as effective methods of analgesia during procedural-related pain or discomfort. Read More

Cent European J Urol 2017 9;70(4):372-377. Epub 2017 Oct 9.

Medical Park Ankara Hospital, Department of Urology, Ankara, Turkey.

Introduction: The aim of this study was to find an ideal method for the application of a transrectal ultrasound-guided prostate biopsy (TRUS-Bx) without deteriorating patient comfort.

Material And Methods: TRUS-Bx was applied in a total of 93 patients. Taking the application method into consideration, these patients were divided into three groups, each consisting of 31 patients. Read More

Urology 2018 May 1;115:8-13. Epub 2018 Feb 1.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

Objective: To describe our procedural technique and initial outcomes performing in-office transperineal prostate biopsies using the PrecisionPoint Transperineal Access System (Perineologic, Cumberland, MD).

Patients And Methods: Following institutional review board approval, we retrospectively reviewed the records of men who underwent an in-office transperineal prostate biopsy using the PrecisionPoint device. Records were reviewed for baseline characteristics, biopsy results, and postbiopsy complications. Read More

Agri 2017 Oct;29(4):151-156

Department of Urology, Samsun Training and Research Hospital, Health Sciences University, Samsun, Turkey.

Objectives: The aim of the study was investigate the pain palliation effect of 2% dose of lidocaine on the periprostatic nerve block in prostate biopsy patients.

Methods: Extended (12 cores) and saturation (22 cores) biopsy patients were included. The patients were separated into three groups: extended biopsy patients (Group I), saturation biopsy patients (Group II), and control group patients undergoing a biopsy procedure for the first time (Group III). Read More

World J Urol 2018 Feb 23;36(2):193-199. Epub 2017 Nov 23.

Research Center Applied to Public Health, School of Medicine, Autonomous University of Sinaloa, Campus 2. Av. Cedros y Calle Sauces. Fracc. Los Fresnos, 80019, Culiacan, Sinaloa, Mexico.

Background: Recent trends in prostate biopsy analgesia suggest a combination anesthetic to provide better pain relief than periprostatic nerve block (PPNB) alone. This study aimed to demonstrate the efficacy and safety of three intrarectal local anesthesia (IRLA) combined with PPNB in patients undergoing transrectal ultrasonography (TRUS)-guided prostate biopsy.

Methods: In this prospective, randomized study, 120 prostate biopsy patients were equally divided into four IRLA groups: group 1 (placebo) received simple lubrication; group 2 received 2% lidocaine gel; group 3 received 100 mg indomethacin suppository and group 4 received 5% prilocaine/lidocaine (EMLA) cream. Read More

Urol Int 2017 30;99(4):373-383. Epub 2017 Oct 30.

Objective: The study aims to review the current evidence to determine the efficiency and safety of intrarectal topical anesthesia (ITA) for transrectal ultrasound-guided prostate biopsy.

Materials And Methods: A comprehensive search of the literature was performed using Medline, Embase and Cochrane central register of controlled trials. All randomized controlled trials (RCTs) comparing the efficacy and safety of periprostatic nerve block (PNB), ITA, and PNB combined with ITA were included. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2017 08;49(4):643-647

Department of Urology,Peking University People's Hospital,Beijing 100044, China.

Objective: To examine the effects of perioperative intravenous administration of flurbiprofen axetil (FA) on pain associated with transrectal ultrasound-guided prostate biopsy.

Methods: This was a randomized,controlled study. Eighty-one patients who underwent 12 core prostate biopsy were included in the study. Read More

Arch Ital Urol Androl 2017 Jun 30;89(2):106-109. Epub 2017 Jun 30.

Department of Urology, University Hospital "Ospedali Riuniti", Ancona.

Purpose: Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract. It is usually considered a contraindication to transrectal ultrasound-guided prostate biopsy (TRUSBx). The aim of this study was to investigate the safety of TRUSBx in a small cohort of patients with CD. Read More

Can J Urol 2017 Jun;24(3):8795-8801

Department of Urology, Mayo Clinic, Jacksonville, Florida, USA.

Introduction: To compare visual analog scale (VAS) pain scores between patients with a 2-minute versus 10-minute delay of peri-prostatic lidocaine injection prior to transrectal ultrasound-guided prostate biopsies (TRUS-bx).

Materials And Methods: Eighty patients who underwent standard 12-core TRUS-bx by a single surgeon were prospectively randomized into four different treatment arms: bibasilar injection with a 2-minute delay, bibasilar injection plus a single apical injection with a 2-minute delay, bibasilar injection with a 10-minute delay, and bibasilar injection plus a single apical injection with a 10-minute delay. Patients were asked to report their level of pain on the VAS (0-10, with 10 indicating unbearable pain) at the following intervals: probe insertion (baseline), after each core, and post-procedure. Read More

Prostate Cancer Prostatic Dis 2017 09 9;20(3):311-317. Epub 2017 May 9.

Division of Surgery and Interventional Science, University College London, London, UK.

Background: Despite high rates of disease misclassification and sepsis, the use of transrectal biopsy remains commonplace. Transperineal mapping biopsies mitigate these problems but carry increased cost and patient burden. Local anaesthetic, multiparametric magnetic resonance imaging (MRI)-targeted transperineal biopsy may offer an alternative. Read More

Scand J Urol 2017 Aug 26;51(4):245-250. Epub 2017 Apr 26.

a Department of Urology , Jikei University School of Medicine , Tokyo , Japan.

Objective: The aim of this study was to compare the effectiveness of caudal block (CB) versus periprostatic nerve block (PPNB), both with intrarectal local anesthesia (IRLA), in reducing pain during transrectal ultrasonography (TRUS)-guided prostatic biopsy.

Materials And Methods: This study included 532 patients: 266 patients received CB with IRLA and 266 patients PPNB with IRLA. A visual analogue scale (VAS) was applied to prospectively evaluate pain (1) at induction of anesthesia, (2) at insertion of the TRUS probe, (3) at needle penetration to the prostate, and (4) throughout the biopsy procedure. Read More

J Urol 2017 Oct 8;198(4):839-847. Epub 2017 Apr 8.

Department of Urology, University of California-Los Angeles, Los Angeles, California; Center for Advanced Surgical and Interventional Technology, University of California-Los Angeles, Los Angeles, California. Electronic address:

Purpose: Focal laser ablation is a potential treatment in some men with prostate cancer. Currently focal laser ablation is performed by radiologists in a magnetic resonance imaging unit (in bore). We evaluated the safety and feasibility of performing focal laser ablation in a urology clinic (out of bore) using magnetic resonance imaging-ultrasound fusion for guidance. Read More

BJU Int 2017 08 25;120(2):164-167. Epub 2017 May 25.

Department of Surgery, Austin Health, University of Melbourne, Melbourne, Vic., Australia.

Strahlenther Onkol 2017 Jun 2;193(6):452-458. Epub 2017 Feb 2.

Centre of Radiotherapy, National Institute of Oncology, Ráth György u. 7-9, 1122, Budapest, Hungary.

Purpose: To present the feasibility and complications of transperineal fiducial marker implantation in prostate cancer patients undergoing image-guided radiotherapy (IGRT) METHODS AND MATERIALS: Between November 2011 and April 2016, three radiopaque, gold-plated markers were transperineally implanted into the prostate of 300 patients under transrectal ultrasound guidance and with local anaesthesia. A week after the procedure patients filled in a questionnaire regarding pain, dysuria, urinary frequency, nocturia, rectal bleeding, hematuria, hematospermia or fever symptoms caused by the implantation. Pain was scored on a 1-10 scale, where score 1 meant very weak and score 10 meant unbearable pain. Read More

Arch Ital Urol Androl 2016 Dec 30;88(4):308-310. Epub 2016 Dec 30.

Unit of Urology, Department of Human Pathology, University of Messina, Messina,.

Transrectal Ultrasound (TRUS) guided prostate biopsy is regarded as the gold standard for prostate cancer diagnosis. The majority of patients perceive TRUS-guided prostate biopsy as a physically and psychologically traumatic experience. We aimed to compare in this paper the efficacy of three different anesthesia techniques to control the pain during the procedure. Read More

J Pain Res 2016 11;9:787-796. Epub 2016 Oct 11.

Beijing Tian Tan Hospital, Capital Medical University, Neurology Research Division, China National Clinical Research Center for Neurological Disease, Beijing, People's Republic of China.

Background: A meta-analysis was performed to evaluate the efficacy and safety of intrarectal local anesthestic (IRLA), periprostatic nerve block (PPNB), and the combined modalities in alleviating the pain during transrectal ultrasound (TRUS)-guided prostate biopsy.

Materials And Methods: A literature review was performed to identify all published randomized controlled trials (RCTs) about IRLA vs no anesthesia or placebo gel; PPNB vs no injection, periprostatic placebo injection, or IRLA; combined PPNB and IRLA vs PPNB alone; and combined PPNB and intraprostatic nerve block (IPNB) vs PPNB alone before TRUS-guided biopsy. Sources included MEDILINE, EMBASE, and Cochrane Library from 1980 to 2016. Read More

Arch Ital Urol Androl 2016 Oct 5;88(3):223-227. Epub 2016 Oct 5.

Surgery Department, Section of Urology, ASUR Marche Area Vasta 3, Macerata Hospital, Macerata.

Introduction And Objective: Transrectal ultrasound guided prostate biopsy (TRUS-Bx) is the definitive step in the diagnosis of prostate cancer (CaP). Patients (pts) generally experience significant pain during the procedure at the point that biopsy should be accompanied by some form of anesthesia. Several different factors influence pain perception (PP) during TRUS-Bx. Read More

Urol Oncol 2017 01 28;35(1):31.e7-31.e12. Epub 2016 Sep 28.

Department of Urology, Rush University Medical Center, Chicago, IL.

Introduction And Objective: The Prostate Imaging Reporting and Data System (PI-RADS) score was developed to evaluate lesions in the peripheral and transition zone on multiparametric magnetic resonance imaging (mpMRI) of the prostate. We aim to determine if the PI-RADS scoring system can be used to evaluate central zone lesions on mpMRI.

Materials And Methods: A retrospective review of 73 patients who underwent mpMRI/ultrasound (US) fusion-guided biopsy of 143 suspicious lesions between February 2014 and October 2015 was performed. Read More

Pak J Med Sci 2016 Jul-Aug;32(4):978-82

Yang Gao, Department of Anesthesiology, The First Hospital of Jilin University, Jilin, China.

Objective: To compare caudal block with intrarectal local anesthesia plus periprostatic nerve block for transrectal ultrasound guided prostate biopsy.

Methods: One hundred and ninety patients scheduled for transrectal ultrasound guided prostate biopsy were randomized equally into Group-A who received caudal block (20 ml 1.2% lidocaine) and Group-B who received intrarectal local anesthesia (0. Read More

Urol Int 2016 6;97(4):416-420. Epub 2016 Sep 6.

Department of Urology, Bozyaka Training and Research Hospital, Izmir, Turkey.

Introduction: The study aimed to compare the efficiency of periprostatic nerve blockage (PPNB) and intrarectal lidocaine gel (PPNB + gel) with a transperineal prostatic block (TPPB) technique during transrectal ultrasound-guided prostate biopsy (TRUS-PBx) in patients with anorectal pathologies.

Materials And Methods: A total of 376 patients who underwent TRUS-PBx were randomized into 2 groups. Group-I (n = 198) received TPPB with 10 ml 2% prilocaine, and group-II (n = 178) received intrarectal administration of 10 ml 2% lidocaine gel followed by PPNB with 10 ml 2% prilocaine. Read More

Zhonghua Wai Ke Za Zhi 2016 Aug;54(8):632-6

Department of Urology, College of Clinical Medicine, Yangzhou University, Subei People's Hospital, Yangzhou 225001, China.

Objective: To evaluate the anesthetic efficacy of periprostatic nerve block in transrectal ultrasound(TRUS) guided biopsy on different prostate volume.

Methods: A total of 568 patients received prostate biopsy in Department of Urology, Subei People's Hospital from May 2013 to September 2015 were retrospectively studied. All patients were divided into local anesthesia group and nerve block group according to different way of anesthesia. Read More

Medicine (Baltimore) 2016 Jul;95(28):e4184

Department of Urology, Clinical Medical School, Yangzhou University, Yangzhou, Jiangsu Province, China.

Objective: The objective of this study was to evaluate the anesthetic efficacy of periprostatic nerve block (PNB) in transrectal ultrasound (TRUS)-guided biopsy on different prostate volume.

Methods: A total of 568 patients received prostate biopsy in our hospital from May 2013 to September 2015 and were retrospectively studied. All patients were divided into local anesthesia group (LAG) and nerve block group (NBG). Read More

Urology 2016 Aug 26;94:24-8. Epub 2016 Apr 26.

Department of Pathology, Wheeling Hospital, Wheeling, WV.

Objective: To report the incidence of prostate cancer diagnosis and quality of life outcomes following transperineal prostate biopsy.

Methods: Forty-six consecutive patients underwent office-based transperineal prostate biopsy for an elevated prostate-specific antigen and a normal digital rectal examination without prior prostate biopsy. Prior to biopsy, a repeat prostate-specific antigen was obtained to ensure persistent elevation. Read More

ANZ J Surg 2017 Apr 18;87(4):262-265. Epub 2016 Apr 18.

Department of Urology, Wellington Hospital, Wellington, New Zealand.

Background: To determine if a short, clinically sufficient and manageable time delay after peri-prostatic nerve block (PNB) reduces pain during transrectal ultrasound (TRUS)-guided prostate biopsy.

Methods: This was a prospective, randomized controlled trial. All patients who underwent TRUS-guided prostate biopsy between February and June 2014 were randomized into waiting or control groups. Read More

Patient Prefer Adherence 2016 11;10:147-52. Epub 2016 Feb 11.

Division of Urology, Taipei City Hospital, National Taipei University of Nursing and Health Science, Taipei, Taiwan, Republic of China; Department of Urology, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China.

Background: To assess the utilization of stress management in relieving anxiety and pain among patients who undergo transrectal ultrasound (TRUS)-guided biopsy of the prostate.

Methods: Eighty-two patients admitted to a community hospital for a TRUS biopsy of the prostate participated in this case-controlled study. They were divided into an experimental group that was provided with stress management and a control group that received only routine nursing care. Read More

Asian J Androl 2017 Jan-Feb;19(1):62-66

Department of Urology, Addenbrookes Hospital, Cambridge, UK.

We aimed to determine short-term patient-reported outcomes in men having general anesthetic transperineal (TP) prostate biopsies. A prospective cohort study was performed in men having a diagnostic TP biopsy. This was done using a validated and adapted questionnaire immediately post-biopsy and at follow-up of between 7 and 14 days across three tertiary referral hospitals with a response rate of 51. Read More

Actas Urol Esp 2016 Jul-Aug;40(6):378-85. Epub 2016 Feb 26.

Unidad de Investigación en Urología, Instituto de Investigación Vall d'Hebron, Barcelona, España.

Introduction: New generations of tumor markers used to detect prostate cancer (PCa) should be able to discriminate men with aggressive PCa of those without PCa or nonaggressive tumors. The objective of this study has been to validate Prostate Health Index (PHI) as a marker of aggressive PCa in one academic institution.

Methods: PHI was assessed in 357 men scheduled to prostatic biopsy between June of 2013 and July 2014 in one academic institution. Read More

Int Braz J Urol 2015 Sep-Oct;41(5):859-63

Department of Urology, Bagcilar Training and Research Hospital, 6. Sokak, Bagcilar/Istanbul, Turkey.

Purpose: Studies about the anesthesia techniques during transrectal ultrasound guided prostate biopsy (TRUS-Bx) are usually focused on pain relief. Although patients' tolerance is an important issue in TRUS-Bx, cancer detection rate (CDR) must not be ignored. In this study, we compared the impact of intrarectal lidocaine gel anesthesia (IRLA) and periprostatic nerve blockade (PNB) techniques on CDR. Read More

Scand J Urol 2016 Jun 3;50(3):206-11. Epub 2015 Dec 3.

c Netherlands Institute for Health Services Research (NIVEL) , Utrecht , The Netherlands ;

Objective: The aim of this study was to investigate how patients experience diagnostic urological procedures performed by urologists, junior residents and senior residents, and to assess the influence of procedure-related factors on patient experiences.

Methods: Data were collected during 222 procedures: 84 transrectal ultrasound-guided prostate biopsies (TRUSP; urologists n = 39, residents n = 45) and 138 urethrocystoscopies (UCS; urologists n = 44, residents n = 94) in six hospitals. Patient experiences were assessed using a questionnaire focusing on pain, comfort and satisfaction (visual analogue scale, 0-10) and communication aspects on a four-point Likert scale. Read More

J Endourol 2015 Dec 8;29(12):1412-7. Epub 2015 Sep 8.

3 Department of Anesthesia and Intensive Care, Faculty of Medicine, Selcuk University , Konya, Turkey .

Purpose: To evaluate the use of spinal anesthesia by reducing anesthetic agent dose to provide better analgesia with minimal side effects without sacrificing the outpatient setting for prostate biopsy. In this study, efficacy and tolerability of selective low-dose spinal anesthesia versus intrarectal local anesthesia (IRLA) plus periprostatic nerve blockade (PPNB) were compared.

Methods: Between September 2012 and April 2013, 100 patients, aged 40 to 80 years, prostate-specific antigen (PSA) ≥4 ng/mL, abnormal digital rectal examinations, and enrolled for biopsy were included in the present study. Read More

Indian J Urol 2015 Jul-Sep;31(3):202-8

Department of Radiology, All India Institute of Medical Sciences, New Delhi - 110 029, India.

Advances in imaging technology, especially in the last two decades, have led to a paradigm shift in the field of image-guided interventions in urology. While the traditional biopsy and drainage techniques are firmly established, image-based stone management and endovascular management of hematuria have evolved further. Ablative techniques for renal and prostate cancer and prostate artery embolization for benign prostatic hypertrophy have evolved into viable alternative treatments. Read More

Anesth Pain Med 2015 Jun 22;5(3):e22568. Epub 2015 Jun 22.

Department of Urology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: TRUS-guided needle biopsy of the prostate gland is the current standard method used for diagnosis of prostate cancer. Pain control during this procedure is through the use of i.v. Read More

Int Braz J Urol 2015 Jan-Feb;41(1):101-8; discussion 109

Department of Urology, University of Kocaeli, Turkey.

Objectives: To analyze the efficacy of intrarectal ice application as an anesthetic method prior to transrectal ultrasound (TRUS) guided prostate biopsy.

Materials And Methods: A total of 120 consecutive men were included into the study prospectively. Patients were equally randomized as group 1 and 2 with 60 patients each. Read More

Actas Urol Esp 2015 Sep 6;39(7):414-9. Epub 2015 Mar 6.

Servicio de Urología, Instituto Valenciano de Oncología, Valencia, España.

Objectives: To quantify the degree of pain experienced by patients who undergo ultrasound-guided transrectal prostate biopsy in standard clinical practice and assess the clinical factors associated with increased pain.

Material And Methods: Analysis of a multicenter series of patients with prostate biopsy according to standard clinical practice. The biopsy was performed transrectally with a protocol of local anesthesia on the posterolateral nerve bundle. Read More

Urol J 2015 Feb 22;12(1):2014-9. Epub 2015 Feb 22.

Department of Urology, Oncology Training and Research Hospital, 06530 Demetevler, Ankara, Turkey.

Purpose: To investigate the efficacy of a novel anesthetic technique called iliohypogastric nerve block (INB) for pain control in patients undergoing prostate biopsy.

Materials And Methods: A total of 59 consecutive patients who underwent transrectal ultrasound guided prostates biopsies were included in the study. Patients were randomized into four groups: (1) control, no method of anesthesia was administered, (2) intrarectal prilocaine-lidocaine cream application, (3) INB and (4) INB + intrarectal prilocaine-lidocaine cream application (combined group). Read More

Arch Ital Urol Androl 2014 Dec 30;86(4):340-3. Epub 2014 Dec 30.

Department of Urology, University Hospital "S. Anna", Ferrara.

Objectives: We report in this singlecenter study our results of a five-year experience in the administration of lidocaine spray (LS) during ultrasound-guided prostate biopsy (TPB).

Material And Methods: Between August 2008 and July 2013 a total of 1022 consecutive male patients scheduled for TPB with elevate PSA (≥ 4 ng/ml) and (or) abnormal digital rectal and (or) suspect TRUS were considered eligible for the study. Each patient was treated under local anaesthesia with LS (10 gr/100 ml), applied two minutes before the procedure. Read More

Vestn Khir Im I I Grek 2015 ;174(5):75-8

Prostate biopsy guided by transrectal ultrasonography (TRUS) is largely used in prostate cancer diagnostics. This procedure is usually quite painful and fear of pain could scare patients from this important research. The aim of the study was to compare methods of anesthesia for prostate biopsy. Read More

Magy Onkol 2014 Sep 2;58(3):182-7. Epub 2014 Aug 2.

Sugárterápiás Központ, Országos Onkológiai Intézet, Budapest, Hungary.

The purpose of the study was to introduce the use of the gold radiopaque markers implanted into the prostate for image-guided radiotherapy of prostate cancer patients and to present the side effects caused by the marker implantation. Between November 2011 and November 2013, three radiopaque, gold-plated markers (Best Medical International, Springfield, VA, USA, 1.0 mm x 3. Read More

Radiology 2015 Jan 8;274(1):181-91. Epub 2014 Sep 8.

From the Radiation Medicine Program (C.M., D.I., J.P., J.L., J.A., A.S., W.D.F., M.M., C.C., R.B., A.B., D.A.J., P.C., K.K.B.) and Department of Biostatistics (E.G.A.), Princess Margaret Cancer Centre, 610 University Ave, Room 5-809, Toronto, ON, Canada M4X 1C3; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada (C.M., D.I., A.S., M.M., C.C., G.M., R.B., A.B., D.A.J., P.C., K.K.B.); Department of Radiation Oncology, Wellington Cancer Centre, Wellington, New Zealand (D.I.), Departments of Anesthesia (G.O.) and Pathology (A.J.E.), University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Odette Cancer Center, Toronto, Ontario, Canada (G.M.); Department of Radiation Oncology, Wellington Cancer Centre, Wellington, New Zealand (D.I.); and Joint Department of Medical Imaging, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (M.A.H.).

Purpose: To determine if the integration of diagnostic magnetic resonance (MR) imaging and MR-guided biopsy would improve target delineation for focal salvage therapy in men with prostate cancer.

Materials And Methods: Between September 2008 and March 2011, 30 men with biochemical failure after radiation therapy for prostate cancer provided written informed consent and were enrolled in a prospective clinical trial approved by the institutional research ethics board. An integrated diagnostic MR imaging and interventional biopsy procedure was performed with a 1. Read More

Aktuelle Urol 2014 Jul 28;45(4):327-8. Epub 2014 Aug 28.

Klinikum Kempten-Oberallgäu gGmbH, Klinik für Urologie.

Aktuelle Urol 2014 Jul 28;45(4):320-3. Epub 2014 Aug 28.

Universitätsklinikum der RWTH Aachen.

J Clin Ultrasound 2015 Jun 26;43(5):288-94. Epub 2014 Aug 26.

Department of Urology, Suluova State Hospital, Amasya, Turkey.

Background: To assess whether patient comfort could be increased by adding procedural sedation and analgesia (PSAA) to periprostatic nerve block (PNB) in patients undergoing transrectal ultrasound-guided prostatic biopsy (TRUS-PB).

Methods: This was a prospective, randomized (1:2) trial comparing PNB with the combination of PSAA+PNB in patients undergoing TRUS-PB. PNB was achieved by using lidocaine gel and lidocaine and bipuvacaine infiltration. Read More

Int J Urol 2015 Jan 21;22(1):62-8. Epub 2014 Aug 21.

Department of Urology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an; Department of Urology, Panzhihua Central Hospital, Panzhihua, China.

Objectives: To evaluate the efficacy and safety of combined intrarectal local analgesia and periprostatic nerve block versus periprostatic nerve block alone for pain control during transrectal ultrasound-guided prostate biopsy.

Methods: We comprehensively searched PubMed, Embase and the Cochrane Library trials. Studies comparing the two techniques were identified and pooled for cumulative analysis. Read More