162,463 results match your criteria Techniques in hand & upper extremity surgery[Journal]


Sarcopenia and variation in the Human Leukocyte Antigen complex.

J Gerontol A Biol Sci Med Sci 2019 Feb 17. Epub 2019 Feb 17.

Epidemiology and Public Health Group, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, UK.

Background: Aging is characterized by chronic inflammation plus muscle mass and strength loss, termed sarcopenia. Human Leukocyte Antigen (HLA) types are drivers of autoimmune disease, although with limited penetrance. We tested whether autoimmune diagnoses are associated with sarcopenia, and whether HLA types and related genetic variants associate with sarcopenia in autoimmune disease free older people. Read More

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http://dx.doi.org/10.1093/gerona/glz042DOI Listing
February 2019

Ursolic Acid Exhibits Potent Anticancer Effects in Human Metastatic Melanoma Cancer Cells (SK-MEL-24) via Apoptosis Induction, Inhibition of Cell Migration and Invasion, Cell Cycle Arrest, and Inhibition of Mitogen-Activated Protein Kinase (MAPK)/ERK Signaling Pathway.

Med Sci Monit 2019 Feb 17;25:1283-1290. Epub 2019 Feb 17.

Department of Hand and Pediatric Surgery, The First Hospital of Jilin University, Changchun, Jilin, China (mainland).

BACKGROUND Ursolic acid is an important bioactive triterpenoid that has been reported to be of tremendous pharmacological importance. However, the anticancer potential of ursolic acid has not been examined against metastatic melanoma cells. Therefore, in this study we examined the anticancer potential of ursolic acid and its mode of action. Read More

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http://dx.doi.org/10.12659/MSM.913069DOI Listing
February 2019

NO donors induce vascular relaxation by different cellular mechanisms in hypertensive and normotensive rats.

Nitric Oxide 2019 Feb 14. Epub 2019 Feb 14.

Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address:

Purpose: This study investigated the intracellular mechanisms involved in the vasodilatation induced by the classic NO donor SNP and the non-classic NO donor cis-[Ru(bpy)2(py)(NO2)](PF6) (or RuBPY) in mesenteric resistance arteries obtained from renal hypertensive (2K-1C) and normotensive (2K) rats.

Methods: On the basis of fluorimetric assays in cultured vascular smooth muscle cells (VSMCs) isolated from 2K-1C and 2K rats, we measured NO release from SNP and RuBPY, cytosolic Ca concentration ([Ca]c), and reactive oxygen species (ROS) with the selective probes DAF-2DA, Fluo-3AM and the more selective probe for peroxynitrite (7-CBA), respectively. We determined isometric tension in mesenteric arteries to assess SNP- and RuBPY-induced relaxation. Read More

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http://dx.doi.org/10.1016/j.niox.2019.02.004DOI Listing
February 2019

Endoscopic retrieval of retracted flexor tendons: An atraumatic technique.

J Plast Reconstr Aesthet Surg 2019 Jan 14. Epub 2019 Jan 14.

Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Hacettepe University, Sihhiye, 06080 Ankara, Turkey.

Background: The repair of retracted flexor tendons is a challenging problem for hand surgeons. The tendon stump should be handled in an atraumatic manner because any microtrauma to the sheath and tendon can lead to poor functional outcomes.

Methods: Twenty-three patients with flexor zone 2 injuries and intraoperative finding of retracted tendons were randomly divided into two groups: endoscopic retrieval group and proximal incision group. Read More

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http://dx.doi.org/10.1016/j.bjps.2019.01.007DOI Listing
January 2019

Differences between flexion and extension synergy-driven coupling at the elbow, wrist, and fingers of individuals with chronic hemiparetic stroke.

Clin Neurophysiol 2019 Jan 31;130(4):454-468. Epub 2019 Jan 31.

Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, USA; Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:

Objective: The flexion and extension synergies were quantified at the paretic elbow, forearm, wrist, and finger joints within the same group of participants for the first time. Differences in synergy expression at each of the four joints were examined, as were the ways these differences varied across the joints.

Methods: Twelve post-stroke individuals with chronic moderate-to-severe hemiparesis and six age-matched controls participated. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.010DOI Listing
January 2019

Data fitting approach more critical than exposure scenarios and treatment of censored data for quantitative microbial risk assessment.

Water Res 2019 Feb 4;154:45-53. Epub 2019 Feb 4.

Instituto de Investigaciones para la Industria Química (INIQUI), CONICET, Universidad Nacional de Salta (UNSa), Av. Bolivia 5150, Salta, 4400, Argentina; Singapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, 637551, Singapore; Facultad de Ingeniería, UNSa, Salta, Argentina. Electronic address:

Recreational waters are a source of many diseases caused by human viral pathogens, including norovirus genogroup II (NoV GII) and enterovirus (EV). Water samples from the Arenales river in Salta, Argentina, were concentrated by ultrafiltration and analyzed for the concentrations of NoV GII and EV by quantitative PCR. Out of 65 samples, 61 and 59 were non-detects (below the Sample Limit of Detection limit, SLOD) for EV and NoV GII, respectively. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.041DOI Listing
February 2019

Prospective Clinical Trial Comparing Trapezial Denervation With Trapeziectomy for the Surgical Treatment of Arthritis at the Base of the Thumb.

J Surg Res 2019 Feb 13;238:144-151. Epub 2019 Feb 13.

The Pulvertaft Hand Surgery Centre, Royal Derby Hospital, Derby, United Kingdom.

Background: Trapeziectomy is considered to be the "gold standard" procedure for first carpometacarpal joint (first CMCJ) osteoarthritis. First CMCJ denervation offers the potential benefit of a shorter procedure with bone and joint preservation and swift postoperative rehabilitation. This trial aimed to compare functional outcomes, patient satisfaction, quality of life, and cost effectiveness following these treatments. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.011DOI Listing
February 2019

Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population.

Clin Oral Investig 2019 Feb 15. Epub 2019 Feb 15.

Department of Periodontal Medicine, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.

Objectives: Periodontal inflammation is regarded as a risk factor for drug-induced gingival overgrowth (DIGO). In order to elucidate the involvement of periodontal inflammation in DIGO, the periodontal status of subjects who do not develop DIGO despite receiving causative drugs (non-responders) needs to be examined. Therefore, the aim of the present study which was a pilot study was to assess periodontal inflammatory variables in responders (calcium channel blocker induced-GO patients), non-responders, and patients who did not receive causative drugs (non-consumers). Read More

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http://dx.doi.org/10.1007/s00784-019-02846-8DOI Listing
February 2019
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The impact of improved water, sanitation and hygiene on oral rotavirus vaccine immunogenicity in Zimbabwean infants: sub-study of a cluster-randomized trial.

Clin Infect Dis 2019 Feb 16. Epub 2019 Feb 16.

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

Background: Oral vaccines have lower efficacy in developing compared to developed countries. Poor water, sanitation and hygiene (WASH) may contribute to reduced oral vaccine immunogenicity.

Methods: We conducted a cluster-randomized 2x2 factorial trial in rural Zimbabwe (NCT01824940). Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz140DOI Listing
February 2019
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A quantitative taxonomy of human hand grasps.

J Neuroeng Rehabil 2019 Feb 15;16(1):28. Epub 2019 Feb 15.

Information Systems Institute, University of Applied Sciences Western Switzerland (HES-SO), Sierre, Switzerland.

Background: A proper modeling of human grasping and of hand movements is fundamental for robotics, prosthetics, physiology and rehabilitation. The taxonomies of hand grasps that have been proposed in scientific literature so far are based on qualitative analyses of the movements and thus they are usually not quantitatively justified.

Methods: This paper presents to the best of our knowledge the first quantitative taxonomy of hand grasps based on biomedical data measurements. Read More

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http://dx.doi.org/10.1186/s12984-019-0488-xDOI Listing
February 2019

Repeat hepatectomy with systemic chemotherapy might improve survival of recurrent liver metastasis from colorectal cancer-a retrospective observational study.

World J Surg Oncol 2019 Feb 15;17(1):33. Epub 2019 Feb 15.

Department of Surgery Fujita Health University, 1-98 Dengakugakubo Kutsukake-cho, Toyoake City, Aichi, 470-1192, Japan.

Background: Although hepatectomy for metastatic colorectal cancer (mCRC) prolongs survival in up to 40% of people, recurrence rates approach 70%. We used a multidisciplinary approach to treat recurrent liver metastases, including chemotherapy, surgery, and palliative care. On the other hand, development of chemotherapeutic agents is remarkable and improves long-term survival. Read More

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http://dx.doi.org/10.1186/s12957-019-1575-yDOI Listing
February 2019

Inequalities in the prevalence of undiagnosed hypertension among Bangladeshi adults: evidence from a nationwide survey.

Int J Equity Health 2019 Feb 15;18(1):33. Epub 2019 Feb 15.

Institute for Social Science Research, The University of Queensland, Indooroopilly, 4068, Queensland, Australia.

Background: In recent years, developing countries like Bangladesh are facing a higher burden of non-communicable diseases such as hypertension as a result of demographic transition. Prevalence of hypertension is often studied in this setting. However, evidence on undiagnosed hypertension is not widely available in the existing literature. Read More

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http://dx.doi.org/10.1186/s12939-019-0930-5DOI Listing
February 2019

Comorbidities (excluding lymphoma) in Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Rheumatology Department, Doctor Negrín University Hospital of Gran Canaria, Gran Canaria, Spain.

The information about comorbidities (excluding lymphoma) in primary Sjögren's syndrome (pSS) is relatively scarce. Cardiovascular disease, infections, musculoskeletal conditions or malignancy are likely the most relevant comorbid conditions in pSS. Different infections (particularly oral candidal infections) and fibromyalgia are extremely frequent in the daily clinical practice. Read More

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http://dx.doi.org/10.1093/rheumatology/key329DOI Listing
February 2019

The tissue viability imaging system-Suitable method for discovering minimal skin changes in occupational screenings? Results of a cross-sectional field study.

Skin Res Technol 2019 Feb 16. Epub 2019 Feb 16.

Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Background: For early detection of initial skin changes in occupational screenings, only few objective assessment systems are available.

Objectives: With the aim of assessing an objective measurement method for hand eczema, we trialed the application of the tissue viability imaging (TiVi) system, quantifying erythema non-invasively by polarized light spectroscopy.

Materials And Methods: In a field study with 625 employees of a semiconductor production company, 411 were exposed to prolonged wearing of occlusive gloves in the clean room. Read More

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http://dx.doi.org/10.1111/srt.12686DOI Listing
February 2019

Strategies to inhibit arsenic trioxide-induced cardiotoxicity in acute promyelocytic leukemia.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objective: Arsenic trioxide (ATO) is a drug commonly used for the treatment of acute promyelocytic leukemia (APL). Although ATO has been shown to cause significant improvement in patients, it is associated with serious side effects, which sometimes lead to the patient's death. In this review paper, we examine the reports of ATO-induced cardiotoxicity in APL patients and evaluate the strategies to reduce the incidence of such toxicity. Read More

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http://dx.doi.org/10.1002/jcp.28292DOI Listing
February 2019

Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, and the Department of Medicine, Division of Rheumatology, and the School of Pharmacy, at the University of California, San Francisco (UCSF), San Francisco, California; Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, Ohio; Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. This study was supported by UCB Pharmaceutical Inc. (Xiaojuan Li). T. Shimizu, MD, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, and Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University; A. Cruz, BS, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, and School of Pharmacy, UCSF; M. Tanaka, BS, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; K. Mamoto, MD, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, and Department of Biomedical Engineering, PAMI, Cleveland Clinic; V. Pedoia, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; A.J. Burghardt, BS, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; U. Heilmeier, MD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; T.M. Link, MD, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; J. Graf, MD, Department of Medicine, Division of Rheumatology, UCSF; J.B. Imboden, MD, Department of Medicine, Division of Rheumatology, UCSF; X. Li, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, and Department of Biomedical Engineering, PAMI, Cleveland Clinic. Address correspondence to Dr. T. Shimizu, Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. E-mail: Accepted for publication October 24, 2018.

Objective: To investigate the correlation between changes in radiological quantitative assessment with changes in clinical and functional assessment from baseline to 3 months in patients with rheumatoid arthritis (RA).

Methods: Twenty-eight patients with RA [methotrexate (MTX) and anti-tumor necrosis factor-α (TNF-α) group with high disease activity (n = 18); and MTX group with low disease activity (n = 10)] underwent assessments at baseline and 3 months: clinical [28-joint count Disease Activity Score (DAS28)], functional [Health Assessment Questionnaire (HAQ) and Michigan Hand Outcome Questionnaire (MHQ)], and imaging-based [3 Tesla magnetic resonance imaging (MRI) and high-resolution peripheral quantitative computed tomography (HR-pQCT)]. MR images were evaluated semiquantitatively [RA MRI scoring (RAMRIS)] and quantitatively for the volume of synovitis and bone marrow edema (BME) lesions. Read More

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http://dx.doi.org/10.3899/jrheum.180496DOI Listing
February 2019

Intensive upper limb neurorehabilitation in chronic stroke: outcomes from the Queen Square programme.

J Neurol Neurosurg Psychiatry 2019 Feb 15. Epub 2019 Feb 15.

The National Hospital for Neurology and Neurosurgery, London, UK.

Objective: Persistent difficulty in using the upper limb remains a major contributor to physical disability post-stroke. There is a nihilistic view about what clinically relevant changes are possible after the early post-stroke phase. The Queen Square Upper Limb Neurorehabilitation programme delivers high-quality, high-dose, high-intensity upper limb neurorehabilitation during a 3-week (90 hours) programme. Read More

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http://dx.doi.org/10.1136/jnnp-2018-319954DOI Listing
February 2019

Long-term dental and skeletal effects of mandibular advancement devices in adults with obstructive sleep apnoea: A systematic review.

Int Orthod 2019 Feb 12. Epub 2019 Feb 12.

Seton Hill University, Department of Orthodontics and Dentofacial Orthopedics, Greensburg, PA, USA.

Objective: This systematic review aimed to clarify whether there are any significant long-term sequelae to wearing mandibular advancement devices focusing on dental and skeletal effects in adults with OSA.

Materials And Methods: Databases, including PubMed, Medline, Embase, Web of Science, Cochrane Central Register of Controlled Trials, and SAGE Journals. Hand searches and grey literature were also used. Read More

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http://dx.doi.org/10.1016/j.ortho.2019.01.004DOI Listing
February 2019

Treatment of severe glenoid deficiencies in reverse shoulder arthroplasty: the Glenius Glenoid Reconstruction System experience.

J Shoulder Elbow Surg 2019 Feb 13. Epub 2019 Feb 13.

Traumatology, University Hospitals Leuven, Department of Development and Regeneration, K Katholieke Universiteit (K.U.), Leuven, Belgium.

Background: The treatment of glenoid bone deficiencies in primary or revision total shoulder arthroplasty is challenging. This retrospective study evaluated the short-term clinical and radiologic results of a new custom-made patient-specific glenoid implant.

Methods: We treated 10 patients with severe glenoid deficiencies with the Glenius Glenoid Reconstruction System (Materialise NV, Leuven, Belgium). Read More

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http://dx.doi.org/10.1016/j.jse.2018.11.061DOI Listing
February 2019

Doctor, when can I drive?-the range of elbow motion while driving a car.

J Shoulder Elbow Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Trauma and Hand Surgery, University Hospital, Düsseldorf, Germany.

Background: Immobilization of the upper extremity after an acute injury or postoperatively affects an individual's ability to safely operate a motor vehicle. The elbow is particularly sensitive to immobilization, with subsequent stiffness leading to functional limitations. Most activities of daily living are successfully achieved within a "functional arc" of elbow motion between 30° and 130° of flexion. Read More

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http://dx.doi.org/10.1016/j.jse.2018.11.053DOI Listing
February 2019

Complex radial head and neck fractures treated with modern locking plate fixation.

J Shoulder Elbow Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Orthopedics and Traumatology, University Medical Center of Johannes Gutenberg University, Mainz, Germany.

Background: Internal fixation of complex radial head and neck (CRHN) fractures is difficult, and postoperative complications are common. This study evaluated elbow function and patient clinical status after internal fixation of CRHN fractures with modern locking plates.

Methods: We included 40 patients with 41 fractures (1 bilateral lesion). Read More

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http://dx.doi.org/10.1016/j.jse.2018.11.056DOI Listing
February 2019

Free tissue transfer with the free rectus abdominis flap in high-risk patients above 65 years: A retrospective cohort study.

J Plast Reconstr Aesthet Surg 2019 Jan 11. Epub 2019 Jan 11.

Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Hand and Plastic Surgery, University of Heidelberg, Ludwig-Guttmann-Strasse 13, 67071 Heidelberg, Germany. Electronic address:

Background: Though technically feasible, free tissue transfer carries the risk of perioperative morbidity and mortality in elderly patients. To minimize the operative treatment time and complication rates, we choose the rectus abdominis muscle (RAM) flap.

Methods: Between 2012 and 2017, 34 patients (mean age: 74±7 years, range: 65-89 years) with comorbidities underwent defect reconstruction with a free RAM flap. Read More

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http://dx.doi.org/10.1016/j.bjps.2019.01.005DOI Listing
January 2019

Prospective outcome analysis following tenodesis of the long head of the biceps tendon along with locking plate osteosynthesis for proximal humerus fractures.

Injury 2019 Feb 10. Epub 2019 Feb 10.

Klinik und Poliklinik für Unfallchirurgie, Klinikum rechts der Isar, Technische Universität München, Germany. Electronic address:

Background: Fractures of the proximal humerus are often associated with lesions of the long head of the biceps (LHB) tendon. This often leads to prolonged shoulder pain. Hence, many surgeons decide to perform a tenodesis of the LHB tendon simultaneous to ORIF. Read More

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http://dx.doi.org/10.1016/j.injury.2019.02.003DOI Listing
February 2019

Complications of Volar Locked Plating of Distal Radius Fractures: A Prospective Investigation of Modern Techniques.

Hand (N Y) 2019 Feb 15:1558944719828001. Epub 2019 Feb 15.

1 Duke University Medical Center, Durham, NC, USA.

Background: Although volar locked plating (VLP) of distal radius fractures is common, complications remain a considerable concern for upper extremity specialists using modern techniques.

Methods: Complications following VLP of DR fractures were recorded prospectively from January 2005 to January 2017. Fractures were characterized using the AO classification, and complications were described by severity. Read More

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http://dx.doi.org/10.1177/1558944719828001DOI Listing
February 2019

National Patterns in Surgical Management of Syndactyly: A Review of 956 Cases.

Hand (N Y) 2019 Feb 15:1558944719828003. Epub 2019 Feb 15.

1 Yale University School of Medicine, New Haven, CT, USA.

Purpose: Being one of the most common congenital hand malformations, syndactyly is repaired by orthopedic, plastic, and fellowship-trained general surgeons. Limited multi-institutional outcomes analyses regarding incidence, timing, and type of repair exist.

Methods: All syndactyly cases performed over a 5-year period from 2012-2016 were isolated from the National Surgical Quality Improvement Program Pediatric database. Read More

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http://dx.doi.org/10.1177/1558944719828003DOI Listing
February 2019

The use of the Z-scan technique for the determination of biochemical parameters in children with solid tumors or leukemias supplemented or not with selenium.

Photodiagnosis Photodyn Ther 2019 Feb 12. Epub 2019 Feb 12.

Universidade Federal de São Paulo, Instituto de Ciências Ambientais, Químicas e Farmacêuticas. Rua Prof. Arthur Riedel, 275, Jardim Eldorado, 09972-270, Diadema, SP, Brasil; Faculdade de Medicina do ABC, Laboratório de Analises Clínicas. Av. Principe de Gales, 821, 09060-650, Santo André, SP, Brasil.

Cancer is a disease that affects cell metabolism causing an imbalance in the health of the patient. On the other hand, malnutrition, presented by oncological patients, is caused by both the disease and its treatment. Some serum biochemical parameters cannot be determined by the traditional method of laboratory blood analysis (spectrophotometry). Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.012DOI Listing
February 2019

Psychometric Evaluation of a Measure of Factors Influencing Hand Hygiene Behaviour to Inform Intervention.

J Hosp Infect 2019 Feb 12. Epub 2019 Feb 12.

Irish Centre for Applied Patient Safety and Simulation, School of Medicine, National University of Ireland Galway, Ireland; Discipline of General Practice, School of Medicine, National University of Ireland Galway, Ireland. Electronic address:

Background: Although the hand hygiene (HH) procedure is simple, the related behaviour is complex and is not readily understood, explained, or changed. There is a need for practical tools to provide data that can guide healthcare managers and practitioners not only on the 'what' (the standards that must be met), but also the 'how' (guidance on how to achieve the standards).

Aim: To develop a valid questionnaire to evaluate attitudes to the factors that influence engagement in HH behaviour that can be readily completed, administered, and analysed by healthcare professionals to identify appropriate intervention strategies. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.02.003DOI Listing
February 2019

A review of the etiologies, clinical characteristics, and treatment of canities.

Int J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Hair pigmentation is regulated by follicular melanogenesis, in which the process consists of melanin formation and transfer to keratinocytes in the hair shaft. Human hair follicles contain two types of melanin: the brown-black eumelanin and yellow-red pheomelanin. Eumelanin is commonly present in black and brown hair while pheomelanin is found in auburn and blonde hair. Read More

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http://dx.doi.org/10.1111/ijd.14399DOI Listing
February 2019

Variation in Nonsurgical Treatment Recommendations for Common Upper Extremity Conditions.

J Am Acad Orthop Surg 2019 Feb 12. Epub 2019 Feb 12.

From the Department of Orthopaedic Surgery, Hand and Upper Extremity Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA (Dr. Smits, Dr. Wilkens, Dr. Chen), the Department of Surgery and Perioperative Care, Dell Medical School at the University of Texas at Austin, Austin, TX (Dr. Ring), and the Department of Plastic Surgery, University Medical Center Groningen, Groningen, The Netherlands (Dr. Guitton).

Background: In orthopaedic surgery, there is known surgeon-to-surgeon variation in recommendations for surgery. Variation in recommendations for nonsurgical treatment of common upper extremity conditions for which surgery is discretionary remains unclear.

Methods: One hundred eighty-three surgeons were included after completing six questions on six scenarios of upper extremity conditions regarding nonsurgical treatment recommendations. Read More

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http://dx.doi.org/10.5435/JAAOS-D-17-00882DOI Listing
February 2019
2.527 Impact Factor

Consistent Iodine Status Assessment in Chinese Adults by Different Spot Urinary Iodine Concentrations in a Day Together With Corresponding Correction Coefficients.

J Am Coll Nutr 2019 Feb 15:1-8. Epub 2019 Feb 15.

a Department of Nutrition and Food Hygiene, School of Public Health , Tianjin Medical University , Tianjin , China.

Objective: The aim of this research was to determine the correction coefficients of different spot urinary iodine concentrations (UICs) in a day to predict the early morning UIC, to make the different spot UICs of a day comparable in assessing iodine status in the same population.

Methods: In total, 424 participants aged 18 to 28 years were recruited from Tianjin, China. Three spot urine samples were collected from each participant during three periods of the day (6:30-7:00, 10:00-10:30, and 16:00-16:30). Read More

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http://dx.doi.org/10.1080/07315724.2019.1568324DOI Listing
February 2019

Engaging Stakeholders to Promote Safe Anesthesia and Sedation Care in Young Children.

J Neurosurg Anesthesiol 2019 Jan;31(1):125-128

Department of Anesthesiology and Perioperative Medicine, Neurology, and Psychiatry, University of Rochester Medical Center, Rochester, NY.

An important aspect of any research endeavor is engaging various stakeholders to work toward the common goal of pushing knowledge forward about the question at hand. Research into pediatric anesthetic neurotoxicity could benefit greatly from interventions designed to improve the efforts and dedication of government agencies, pharmaceutical companies, research communities, and most importantly, patients. The Pediatric Anesthesia Neurodevelopment Assessment (PANDA) symposium is a biennial meeting where updates in research in the field are presented, and issues relevant to the community are discussed in round table discussions. Read More

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http://dx.doi.org/10.1097/ANA.0000000000000547DOI Listing
January 2019

Neutrophil-derived lactoferrin induces the inflammatory responses of rheumatoid arthritis synovial fibroblasts via Toll-like receptor 4.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan.

Objectives: Damage-associated molecular patterns (DAMPs) are proposed to drive aberrant stimulation of Toll-like receptors (TLRs) in rheumatoid arthritis (RA) inflamed joints. In the current study we investigated the role of the neutrophil-derived lactoferrin (LTF), as an endogenous ligand for TLR4 in the inflammatory response of RA synovial fibroblasts (RASFs).

Methods: RASFs were stimulated with LTF, and the expressions of inflammatory cytokines in RASFs were measured. Read More

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February 2019

BioVR: a platform for virtual reality assisted biological data integration and visualization.

BMC Bioinformatics 2019 Feb 15;20(1):78. Epub 2019 Feb 15.

Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, One Lomb Memorial Drive, Rochester, NY, 14623, USA.

Background: Functional characterization of single nucleotide variants (SNVs) involves two steps, the first step is to convert DNA to protein and the second step is to visualize protein sequences with their structures. As massively parallel sequencing has emerged as a leading technology in genomics, resulting in a significant increase in data volume, direct visualization of SNVs together with associated protein sequences/structures in a new user interface (UI) would be a more effective way to assess their potential effects on protein function.

Results: We have developed BioVR, an easy-to-use interactive, virtual reality (VR)-assisted platform for integrated visual analysis of DNA/RNA/protein sequences and protein structures using Unity3D and the C# programming language. Read More

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http://dx.doi.org/10.1186/s12859-019-2666-zDOI Listing
February 2019

[Chapter 6. Legal issues and for the health system of the development of a new class of innovative therapy in oncoimmunology: the “Car-T CellS”].

J Int Bioethique Ethique Sci 2018 07;29(2):113-128

Car-T Cells are autologous or allogeneic lymphocytes cells, genetically engineered to express a transmembrane receptor called ?chimeric? because it consists of the assembly of different parts of molecules. These new techniques using biotechnologies (cellular engineering and genetic modifications) are developing in a complex legal context integrating the rules of the European Union (EU) and national rules, aiming to guarantee a high level of security for products and techniques but also for patients. This framework can be either considered as a guaranty for the use of new molecules in a highly secure environment or as an impediment, on the one hand regarding those who want to develop them because of a great complexity in identifying the adequate procedures and regarding the scientific prerequisites expected by the control agencies, and on the other hand by patients who have to wait many years for these innovations to be made available. Read More

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http://dx.doi.org/10.3917/jibes.292.0113DOI Listing

Displacement of Simulated Flabby Tissue by Different Tray Designs and Impression Materials.

J Prosthodont 2019 Feb 15. Epub 2019 Feb 15.

Department of Prosthodontics and Research Institute of Oral Science, College of Dentistry, Gangneung-Wonju National University, Gangneung, South Korea.

Purpose: To compare the effect of 3 tray designs and 3 commonly used impression materials on the displacement of flabby tissue during maxillary edentulous impression by superimposition of 3D digital models.

Materials And Methods: Fifteen maxillary edentulous casts with simulated flabby tissue were fabricated by modifying a standard maxillary edentulous acrylic resin cast. Three types of impression trays were fabricated: trays with conventional relief, trays with additional relief, and trays with an open window. Read More

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http://dx.doi.org/10.1111/jopr.13036DOI Listing
February 2019

[Rare case of palmar disc dislocation after wrist distorsion].

Unfallchirurg 2019 Feb 14. Epub 2019 Feb 14.

Abteilung für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum Tübingen, Eberhard-Karls-University, Hoppe-Seyler-Str.3, 72076, Tübingen, Deutschland.

Objective: The aim of this study was the elaboration of clinical symptoms and image findings in injuries of the wrist and ulnar-sided pain with accompanying damage to the articular disc and the triangular fibrocartilage complex (TFCC).

Material And Methods: This article reports about a 26-year-old male patient who presented to the department of surgery of this hospital after repeated falls onto the right wrist. Following the latest fall there was persistent wrist pain and limited movement, especially in supination. Read More

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http://dx.doi.org/10.1007/s00113-019-0613-0DOI Listing
February 2019

Quantifying upper extremity performance with and without assistance of a soft-Robotic glove in the elderly population: a Kinematic Analysis.

J Rehabil Med 2019 Feb 15. Epub 2019 Feb 15.

Roessingh Research and Development, , 7522 AH Enschede, The Netherlands.

Objective: To explore the direct influence of a soft-robotic glove on movement duration and movement execution in elderly people with decreased hand function during a reach-and-grasp task.

Design: Cross-sectional study.

Patients: Eight subjects, aged 55+ years, with decreased hand function. Read More

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http://dx.doi.org/10.2340/16501977-2535DOI Listing
February 2019

Practice patterns and outcomes with the use of regorafenib in metastatic colorectal cancer: Results from the Regorafenib in Metastatic colorectal cancer - An Indian exploratory analysis study.

South Asian J Cancer 2019 Jan-Mar;8(1):22-26

Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Background: Regorafenib is considered a standard of care as third-line therapy in metastatic colorectal cancers (mCRCs).

Materials And Methods: The study was based on a computerized clinical data form sent to oncologists across the country for entry of anonymized patient data. The data entry form was conceived and generated by the coordinating center's (Tata Memorial Hospital) gastrointestinal medical oncologists and disseminated through personal contacts at academic conferences as well as through E-mail to various oncologists across India. Read More

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http://dx.doi.org/10.4103/sajc.sajc_173_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348777PMC
February 2019

Measurement of 2D:4D Ratio and Neck Circumference in Adolescents: Sexual Dimorphism and its Implications in Obesity - A Cross Sectional Study.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):724-727

Department of Physiology, Saveetha Medical College, Thandalam, Chennai, Tamil Nadu, India.

Introduction: A bidirectional relationship between testosterone and obesity is explained by the hypogonadal obesity cycle and evidence from reports stating that weight loss leads to increased testosterone levels. There is an alarming rise in the prevalence of obesity among children and adolescents. The objectives of the present study were to measure the 2D:4D ratio of adolescent students and study its association with neck circumference (NC). Read More

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http://dx.doi.org/10.4103/ijem.IJEM_414_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330845PMC
February 2019

Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third- or further-line treatment.

Cancer Biol Med 2018 Nov;15(4):443-451

Department of Pulmonary Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

Objective: Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor, fibroblast growth factor receptor, platelet-derived growth factor receptor, c-Kit, and c-MET; therefore, it exhibits both antitumor and anti-angiogenetic activities. A phase III trial has shown that anlotinib improved progression-free survival (PFS) and overall survival (OS) in patients with advanced non-small cell lung cancer (NSCLC), who presented with progressive disease or intolerance after standard chemotherapy. This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment. Read More

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http://dx.doi.org/10.20892/j.issn.2095-3941.2018.0158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372914PMC
November 2018

Investigating the influence of contextual factors in the coordination of chronic mental illness care in a district health system.

Afr Health Sci 2018 Dec;18(4):1027-1035

School of Nursing and Public Health, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Background: The global shift from institution-based to community-based care for chronic mental illness (CMI) care resulted in the de-institutionalization of clients with CMI. However, health systems which have been originally designed for acute hospital-based care do not seem to be appropriately transformed to manage CMI care at a community level.

Aim: The aim of this study was to investigate how contextual factors influenced care coordination for chronic mental illness care within the eThekwini District. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354863PMC
December 2018

Effectiveness of Robot-Assisted Upper Limb Training on Spasticity, Function and Muscle Activity in Chronic Stroke Patients Treated With Botulinum Toxin: A Randomized Single-Blinded Controlled Trial.

Front Neurol 2019 31;10:41. Epub 2019 Jan 31.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

The combined use of Robot-assisted UL training and Botulinum toxin (BoNT) appear to be a promising therapeutic synergism to improve UL function in chronic stroke patients. To evaluate the effects of Robot-assisted UL training on UL spasticity, function, muscle strength and the electromyographic UL muscles activity in chronic stroke patients treated with Botulinum toxin. This single-blind, randomized, controlled trial involved 32 chronic stroke outpatients with UL spastic hemiparesis. Read More

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http://dx.doi.org/10.3389/fneur.2019.00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365972PMC
January 2019

Knowledge and attitude towards dentist-industry relationship and their association with own behavior among dentists working in Saudi Arabia.

Saudi Pharm J 2019 Feb 18;27(2):155-161. Epub 2018 Sep 18.

Department of Psychiatry, College of Medicine, King Saud University, PO Box 7805, Riyadh 11472, Saudi Arabia.

Objectives: To examine the knowledge and attitude towards dentist-industry relationship including accepting gifts, influence on decisions, and accuracy of given information among dentists working in Saudi Arabia. In addition, to examine the association of such knowledge and attitude of dentists' behavior with industry, including sorts of interaction and accepting industrial gifts.

Methods: A cross-sectional study was conducted among dental practitioners working in the private and governmental hospitals located in the various regions of Saudi Arabia. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362275PMC
February 2019

GIS and AHP Techniques Based Delineation of Groundwater Potential Zones: a case study from Southern Western Ghats, India.

Sci Rep 2019 Feb 14;9(1):2082. Epub 2019 Feb 14.

National Centre for Earth Science Studies, Thiruvananthapuram, Kerala, India.

Over-exploitation of groundwater and marked changes in climate over the years have imposed immense pressure on the global groundwater resources. As demand of potable water increases across the globe for human consumption, agriculture and industrial uses, the need to evaluate the groundwater potential and productivity of aquifers also increases. In the recent years, geographic information system based studies have gained much prominence in groundwater exploration because it is rapid and will provide first - hand information on the resource for further developments. Read More

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http://dx.doi.org/10.1038/s41598-019-38567-xDOI Listing
February 2019

Dietary patterns in relation to inflammation in shift workers.

J R Army Med Corps 2019 Feb 13. Epub 2019 Feb 13.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Introduction: Rotational shift work has a considerable effect on immune function and cause inflammation. In addition, it may lead to unhealthy dietary intake. No earlier study has examined the association between dietary patterns and inflammation in rotational shift workers. Read More

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http://dx.doi.org/10.1136/jramc-2018-001119DOI Listing
February 2019

Duodenal switch: Fully stapled technique.

Surg Obes Relat Dis 2019 Jan 22. Epub 2019 Jan 22.

Bariatric Surgeon, North Carolina Surgery, Rex Hospital, Raleigh, North Carolina.

Background: Duodenal switch and single anastomosis modifications continue to gain greater interest among bariatric surgeons. Limiting factors to adoption include concerns around the nutritional management, patient compliance and follow-up, and the technical challenge of the operation. The majority of techniques offered currently use a hand-sewn duodenoileostomy. Read More

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http://dx.doi.org/10.1016/j.soard.2018.12.031DOI Listing
January 2019

Significance of Serum Survivin and -31G/C Gene Polymorphism in the Early Diagnosis of Breast Cancer in Egypt.

Clin Breast Cancer 2019 Jan 6. Epub 2019 Jan 6.

Department of Biochemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), October, Egypt. Electronic address:

Background: Breast cancer is one of the most relevant malignancies among women. Molecular abnormalities in promotor region of survivin gene may account for overexpression of survivin and increased breast cancer risk. This study aimed to explore the potential association between survivin promotor gene -31G/C single nucleotide polymorphism (rs9904341) and its serum level alteration on one hand, and the risk of breast cancer in Egyptian patients on the other hand. Read More

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http://dx.doi.org/10.1016/j.clbc.2019.01.002DOI Listing
January 2019

Inactivated or damaged? Comparing the effect of inactivation methods on influenza virions to optimize vaccine production.

Vaccine 2019 Feb 11. Epub 2019 Feb 11.

Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:

The vast majority of commercially available inactivated influenza vaccines are produced from egg-grown or cell-grown live influenza virus. The first step in the production process is virus inactivation with β-propiolactone (BPL) or formaldehyde (FA). Recommendations for production of inactivated vaccines merely define the maximal concentration for both reagents, leaving the optimization of the process to the manufacturers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193018
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http://dx.doi.org/10.1016/j.vaccine.2019.01.086DOI Listing
February 2019
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Health care worker sensitivity to chlorhexidine-based hand hygiene solutions: A cross-sectional survey.

Am J Infect Control 2019 Feb 11. Epub 2019 Feb 11.

School of Nursing and Midwifery, Deakin University, Geelong, Victoria, Australia; Centre for Quality and Patient Safety Research-Monash Health Partnership, School of Nursing and Midwifery, Deakin University, Burwood, Victoria, Australia. Electronic address:

Background: Health service hand hygiene programs have seen widespread use of chlorhexidine solutions. Reports of both immediate and delayed hypersensitivity to chlorhexidine are increasing among health care workers. This study examined the prevalence of self-reported symptoms of sensitivity to chlorhexidine solutions among health care workers. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.01.006DOI Listing
February 2019

Simulation-Based Training of the Nurse Practitioner in Interventional Radiology.

Tech Vasc Interv Radiol 2019 Mar 2;22(1):26-31. Epub 2018 Nov 2.

Department of Interventional Radiology, University of Miami Hospital & Clinics, Miami, FL. Electronic address:

Advanced practice registered nurses, such as Nurse Practitioners (NPs), can be found working in a variety of settings. Niche practices, such as Interventional Radiology, are highly specialized areas and are often specialties in which few NPs get to orient through during their graduate nursing program clinical rotations. For the NP transitioning into an Interventional Radiology practice, formal on-the-job orientation and training can assist in gaining specialty-based knowledge and competencies in performing interventional procedures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10892516183007
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http://dx.doi.org/10.1053/j.tvir.2018.10.006DOI Listing
March 2019
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