164,606 results match your criteria Techniques in hand & upper extremity surgery[Journal]


Adipofascial Radial Forearm Free Flap for Anterior Skull Base Reconstruction in Complicated Forebrain Oncological Surgery.

J Craniofac Surg 2019 Apr 20. Epub 2019 Apr 20.

Department of Reconstructive Surgery and Hand Surgery, AOU "Ospedali Riuniti" di Ancona.

Background: Radical resections of ethmoidal tumors with intracranial extension present highly complex surgical and reconstructive problems. The purpose of report is to describe the authors' use of adipofascial radial forearm free flaps following unsuccessful anterior cranial fossa oncological surgery.

Methods: Adipofascial radial forearm free flaps were used to treat 3 similar cases of cutaneous fistula following bone resorption with communication to anterior cranial fossa and nasal cavity. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005559DOI Listing

Influence of blood pressure on the effects of low-dose asprin in elderly patients with multiple atherosclerotic risks.

J Hypertens 2019 Jun;37(6):1301-1307

Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.

Objective: We examined whether the efficacy of low-dose acetylsalicylic acid (aspirin) for primary prevention of cardiovascular events is influenced by blood pressure (BP) using data from patients aged 60-85 years with hypertension, dyslipidemia, and/or diabetes, but without cardiovascular disease of the Japanese Primary Prevention Project.

Methods: All patients had received aspirin (100 mg/day) or no aspirin. BP subgroups were defined as low (average SBP from the baseline to the year of the events <130 mmHg), moderate (≥130 and <140 mmHg), and high (≥140 mmHg). Read More

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http://dx.doi.org/10.1097/HJH.0000000000002034DOI Listing

Preoperative Evaluation of Iatrogenic Spinal Accessory Nerve Palsy: What Is the Place for Electrophysiological Testing?

J Clin Neurophysiol 2019 Apr 22. Epub 2019 Apr 22.

Department of Hand Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Purpose: Electrophysiological testing has been used for the early diagnosis of iatrogenic spinal accessory nerve palsy in clinical practice. However, the presence of low-amplitude compound action potential in 70% to 90% of the patients suffering from iatrogenic nerve transection was reported in several studies. We have encountered the same issue and made minor modifications to the methods of electrophysiological testing. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000589DOI Listing

Image Quality Improvement of Hand-held Ultrasound Devices with a Two-stage Generative Adversarial Network.

IEEE Trans Biomed Eng 2019 Apr 24. Epub 2019 Apr 24.

As a widely used imaging modality in the medical field, ultrasound has been applied in community medicine, rural medicine and even telemedicine in recent years. Therefore, the development of portable ultrasound devices has become a popular research topic. However, the limited size of portable ultrasound devices usually degrades the imaging quality, which reduces the diagnostic reliability. Read More

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http://dx.doi.org/10.1109/TBME.2019.2912986DOI Listing

Stimulating intrinsic motivation in millennial students: A new generation, a new approach.

Anat Sci Educ 2019 Apr 25. Epub 2019 Apr 25.

School of Occupational Therapy, College of Health Sciences, Husson University, Bangor, Maine.

There has been a fundamental change in healthcare pedagogy to address the demands and challenges posed by the present generation of millennial students. There is also a growing recognition of the role of intrinsic motivation (IM) as a catalyst in a positive learning experience. The term IM refers to energizing behavior that comes from within an individual and develops due to an inherent interest in the activity at hand. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ase.1884
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http://dx.doi.org/10.1002/ase.1884DOI Listing
April 2019
1 Read

Adapting State-of-the-Art Deep Language Models to Clinical Information Extraction Systems: Potentials, Challenges, and Solutions.

JMIR Med Inform 2019 Apr 25;7(2):e11499. Epub 2019 Apr 25.

Research School of Computer Science, College of Engineering and Computer Science, The Australian National University, Canberra, Australia.

Background: Deep learning (DL) has been widely used to solve problems with success in speech recognition, visual object recognition, and object detection for drug discovery and genomics. Natural language processing has achieved noticeable progress in artificial intelligence. This gives an opportunity to improve on the accuracy and human-computer interaction of clinical informatics. Read More

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http://medinform.jmir.org/2019/2/e11499/
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http://dx.doi.org/10.2196/11499DOI Listing
April 2019
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A Hybrid ADFT Study of the C and C IPR Isomers.

J Phys Chem A 2019 Apr 25. Epub 2019 Apr 25.

This work presents a hybrid auxiliary density functional theory (ADFT) study of the neutral and hexaanionic C and C fullerenes with the aim to determine their ground state structures. To this end all C and C fullerene structures that obey the isolated pentagon rule (IPR) were optimized with the PBE generalized gradient approximation followed by a single-point energy calculation with the PBE0 hybrid functional. Our studies show that this composite approach yields relative energies of giant fullerenes that are accurate to around 1 kcal/mol. Read More

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http://dx.doi.org/10.1021/acs.jpca.9b00665DOI Listing

Incidence and predictors of postoperative ileus after loop ileostomy closure: a systematic review and meta-analysis.

Surg Endosc 2019 Apr 17. Epub 2019 Apr 17.

Center for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1E2, Canada.

Introduction: Postoperative ileus (POI) is regarded as the most clinically significant morbidity following loop ileostomy closure; however, its incidence remains poorly understood. Our objective was therefore to determine the pooled incidence of POI after loop ileostomy closure and identify risk factors associated with its development.

Methods: We systematically searched MEDLINE (via Ovid and PubMed), Embase, the Cochrane Library, Biosis Previews, and Scopus to identify studies reporting the incidence of POI in patients who underwent loop ileostomy closure. Read More

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http://dx.doi.org/10.1007/s00464-019-06794-yDOI Listing

Histological score for degrees of severity in an implant-associated infection model in mice.

Arch Orthop Trauma Surg 2019 Apr 24. Epub 2019 Apr 24.

Department for Trauma- and Hand Surgery, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.

Introduction: Several scores were introduced to diagnose and to classify osteomyelitis in practice. Mouse models are often used to study the pathophysiology of bone infection and to test therapeutic strategies. Aim of the present study was to design a score to diagnose and quantify implant-associated infection in a murine experimental model. Read More

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http://dx.doi.org/10.1007/s00402-019-03188-6DOI Listing

Prognostic significance of preoperative lymph node assessment for patients with stage pN0 esophageal squamous cell carcinoma after esophagectomy.

J Thorac Dis 2019 Mar;11(3):732-743

Department of Thoracic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.

Background: Accurate preoperative lymph node (LN) staging is important for surgical treatments of esophageal squamous cell carcinoma (ESCC). The aim of the study was to investigate the role of preoperative lymph nodes assessment by computed tomography (CT) scans in prognostic estimates and lymph nodes dissection strategy.

Methods: A total of 233 stage pN0 ESCC patients who underwent radical esophagectomy from 2009 to 2016 were included, with the last follow-up time in 2018. Read More

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http://dx.doi.org/10.21037/jtd.2019.02.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462721PMC

Comparison of toxicity and effectiveness between fixed-dose and body surface area-based dose capecitabine.

Ther Adv Med Oncol 2019 15;11:1758835919838964. Epub 2019 Apr 15.

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

Background: Capecitabine is generally dosed based on body surface area (BSA). This dosing strategy has several limitations; however, evidence for alternative strategies is lacking. Therefore, we analyzed the toxicity and effectiveness of fixed-dose capecitabine and compared this strategy with a BSA-based dose of capecitabine in a large set of patients. Read More

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http://dx.doi.org/10.1177/1758835919838964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466460PMC

Long-term results of arthroscopic and mini-open repair of small- to medium-size full-thickness rotator cuff tears.

Shoulder Elbow 2019 May 12;11(1 Suppl):68-76. Epub 2018 May 12.

Department of Orthopedic Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.

Background: This retrospective cohort study evaluated functional outcome and structural integrity after arthroscopic- or mini-open repair of small- to medium-size rotator cuff tears assessed at long-term follow-up.

Methods: All patients operated between 2001 and 2004 were invited to participate. Functional outcome was measured by Constant-Murley Score, Disability of Arm, Shoulder and Hand and Oxford Shoulder Score. Read More

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http://dx.doi.org/10.1177/1758573218773529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463376PMC

Device mechanics and evaluation of inspiratory flow rate required of the beclomethasone dipropionate breath-actuated inhaler.

Allergy Asthma Proc 2019 May;40(3):162-166

R&D Combination Product Development, Teva Pharmaceuticals Ireland, Waterford, Irel.

Approximately 80% of patients with asthma and chronic obstructive pulmonary disease incorrectly use a metered-dose inhaler and, therefore, fail to obtain full benefit from their inhaler medication. Beclomethasone dipropionate (BDP) hydrofluoroalkane, an inhalation aerosol administered a breath-actuated inhaler (BAI) has been designed to improve ease of use over press-and-breathe metered-dose inhalers by eliminating the need for hand-breath coordination. To present the mechanics of the BAI device, assess the minimum reliable inspiratory flow rate required to trigger an actuation, and evaluate if intended users can safely and effectively use the BDP BAI according to the instructions for use (IFU). Read More

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http://dx.doi.org/10.2500/aap.2019.40.4215DOI Listing

Influence of distal radius fractures involving the intermediate column on forearm rotation.

J Orthop Surg Res 2019 Apr 24;14(1):111. Epub 2019 Apr 24.

Department of Orthopedic Surgery, Jinshan Hospital, Fudan University, Shanghai, 201508, People's Republic of China.

Background: The objective of the study was to compare the radiologic and clinical outcome of patients with distal radius fractures involving the intermediate column and distal radial metaphyseal fractures treated conservatively.

Methods: Two cohorts of 52 matched patients with distal radius fractures treated conservatively, one with a fracture involving the intermediate column and the other with no intermediate column fracture, were retrospectively analyzed by examining the data. Patients were matched for age, sex, fracture side, and AO fracture type. Read More

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http://dx.doi.org/10.1186/s13018-019-1155-4DOI Listing

Sample size calculation for stepped-wedge cluster-randomized trials with more than two levels of clustering.

Clin Trials 2019 Apr 24:1740774519829053. Epub 2019 Apr 24.

5 Scientific Center for Quality of Healthcare, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Background/aims: Power and sample size calculation formulas for stepped-wedge trials with two levels (subjects within clusters) are available. However, stepped-wedge trials with more than two levels are possible. An example is the CHANGE trial which randomizes nursing homes (level 4) consisting of nursing home wards (level 3) in which nurses (level 2) are observed with respect to their hand hygiene compliance during hand hygiene opportunities (level 1) in the care of patients. Read More

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http://dx.doi.org/10.1177/1740774519829053DOI Listing

Microwave-Assisted Synthesis of Trazodone and Its Derivatives as New 5-HT Ligands: Binding and Docking Studies.

Molecules 2019 Apr 23;24(8). Epub 2019 Apr 23.

TM Labs Sp. z o.o., Al. W. Beliny-Prażmowskiego 14, 31-514 Kraków, Poland.

Trazodone, a well-known antidepressant drug widely used throughout the world, works as a 5-hydroxytryptamine (5-HT) and α-adrenergic receptor antagonist and a serotonin reuptake inhibitor. Our research aimed to develop a new method for the synthesis of trazodone and its derivatives. In the known methods of the synthesis of trazodone and its derivatives, organic and toxic solvents are used, and the synthesis time varies from several to several dozen hours. Read More

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http://dx.doi.org/10.3390/molecules24081609DOI Listing

Flash flood susceptibility modeling using an optimized fuzzy rule based feature selection technique and tree based ensemble methods.

Sci Total Environ 2019 Jun 6;668:1038-1054. Epub 2019 Mar 6.

Geotechnical Engineering and Artificial Intelligence Research Group (GEOAI), University of Transport Technology, Hano, Viet Nam. Electronic address:

The main objective of the present study was to provide a novel methodological approach for flash flood susceptibility modeling based on a feature selection method (FSM) and tree based ensemble methods. The FSM, used a fuzzy rule based algorithm FURIA, as attribute evaluator, whereas GA were used as the search method, in order to obtain optimal set of variables used in flood susceptibility modeling assessments. The novel FURIA-GA was combined with LogitBoost, Bagging and AdaBoost ensemble algorithms. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.422DOI Listing

Integrating ecosystem services flows into water security simulations in water scarce areas: Present and future.

Sci Total Environ 2019 Jun 20;670:1037-1048. Epub 2019 Mar 20.

Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; University of the Chinese Academy of Sciences, Beijing 100049, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China; Laboratory for Marine Geology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266061, China. Electronic address:

Water resources are indispensable resources for human survival. Researchers have used different methods to evaluate regional water security situations to ensure sustainable development. However, existing water security assessment models focus on the current status of water security in a static state and do not introduce flow characteristics of water resources into regional water security assessments. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.263DOI Listing

Reducing Surgeon's Physical Stress in Minimally Invasive Neurosurgery.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background And Study Aims:  Various minimally invasive approaches are used in neurosurgery. Surgeons must perform nondynamic fine movements in a narrow corridor, so specially designed surgical devices are essential. Unsophisticated instruments may pose potential hazards. Read More

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http://dx.doi.org/10.1055/s-0038-1676622DOI Listing
April 2019
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Systematic review and meta-analysis of association between cognitive tests and on-road driving ability in people with dementia.

Neuropsychol Rehabil 2019 Apr 24:1-42. Epub 2019 Apr 24.

a Department of Rehabilitation and Ageing , University of Nottingham , Nottingham , UK.

Objectives: To assess the strength of association between cognitive tests and on-road driving ability in people with dementia by conducting a systematic review and meta-analysis.

Methods: A literature search strategy was developed using terms related to dementia and driving. Fifteen databases were searched. Read More

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http://dx.doi.org/10.1080/09602011.2019.1603112DOI Listing

Direct visualization of the behavior and shapes of the nanoscale menisci of an evaporating water droplet on a hydrophilic nano-textured surface via high-resolution synchrotron X-ray imaging.

Langmuir 2019 Apr 24. Epub 2019 Apr 24.

Despite the considerable research interest due to omnipresent and practical importance of interfacial phenomena (e.g., wetting and de-wetting) on nano-textured surfaces in the academic and industrial fields, directly visualizing the behavior and shapes of liquid-vapor interfaces between nano-scale structures remains an arduous task because of the resolution limitations of visualization techniques. Read More

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http://dx.doi.org/10.1021/acs.langmuir.8b04109DOI Listing

Effect of L-Tryptophan on Sperm Quality of Tigris Scraper (Capoeta umbla) (Pisces: Cyprinidae) after Cryopreservation.

Cryo Letters 2019 Mar/Apr;40(2):77-82

Karadeniz Technical University Faculty of Forestry, Department of Wildlife Ecology and Management 61080, Trabzon, Turkey.

Background: The aromatic amino acid L-tryptophan is a versatile molecule and needed for the biosynthesis of proteins. Due to metabolic functions, it has been widely used in research and clinical trials.

Objective: The present study aimed to test the usefulness of L-tryptophan as an extender of Tigris scraper (Capoeta umbla) sperm during cryopreservation. Read More

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April 2019
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Patient acceptability of wearable vital sign monitoring technologies in the acute care setting: a systematic review.

J Clin Nurs 2019 Apr 24. Epub 2019 Apr 24.

School of Nursing and Midwifery, Deakin University, 1 Gheringhap Street, Geelong, VIC, 3220, Australia.

Aims And Objectives: To examine patient acceptability of wearable vital sign monitoring devices in the acute setting.

Background: Wearable vital sign monitoring devices may improve patient safety, yet hospital patients' acceptability of these devices is largely unreported.

Design: A systematic review. Read More

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http://dx.doi.org/10.1111/jocn.14893DOI Listing

Effect of the HERVAT neuroeducational program on evoked potential P300 in children with attention deficit disorder.

Actas Esp Psiquiatr 2019 Mar 1;47(2):54-60. Epub 2019 Mar 1.

Departamento de Medicina Legal, Psiquiatría y Anatomía Patológica. Facultad de Medicina. Universidad Complutense. Madrid.

Introduction: Attention deficit disorder (ADD) has been investigated from various perspectives. However, the neurobiological mechanisms underlying this condition remain unknown. Evoked potentials, including P300, can be used to investigate the processes underlying deficient attentional and cognitive functions in children with ADD. Read More

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March 2019
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Nursing Care in Healthcare-Associated Infections: A Scoping Review.

Rev Bras Enferm 2019 Mar-Apr;72(2):476-483. Epub 2019 Apr 18.

Universidade Federal do Rio Grande do Norte. Natal-RN, Brasil.

Objective: To identify and map nursing care to the adult patient with Healthcare-Associated Infections admitted to the Intensive Care Unit.

Method: Scoping Review, conducted in January 2018, through the search of studies in national and international databases, journals, catalogs of theses and dissertations, and websites of Brazilian health institutions. We included full surveys published in the Portuguese, Spanish or English language; which had as object of study the researched subject, besides manuals and protocols. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0418DOI Listing

Comparison of analytical techniques to explain variability in stored drinking water quality and microbial hand contamination of female caregivers in Tanzania.

Environ Sci Process Impacts 2019 Apr 24. Epub 2019 Apr 24.

Environmental and Water Studies, Department of Civil and Environmental Engineering, Stanford University, Stanford, CA, USA and Woods Institute for the Environment, Stanford University, Stanford, CA, USA.

Exposure to fecal contamination continues to be a major public health concern for low-income households in sub-Saharan Africa. Drinking water and hands are known transmission routes for pathogens in household environments. In an effort to identify explanatory variables of water and hand contamination, a variety of analytical approaches have been employed that model variation in E. Read More

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http://dx.doi.org/10.1039/c8em00460aDOI Listing

Persons injured in the 2011 terror attacks in Norway - Relationship between post-traumatic stress symptoms, emotional distress, fatigue, sleep, and pain outcomes, and medical and psychosocial factors.

Disabil Rehabil 2019 Apr 24:1-9. Epub 2019 Apr 24.

a Sunnaas Rehabilitation Hospital , Bjørnemyr , Norway.

Purpose: The main aim was to assess long-term post-traumatic stress symptoms, emotional distress, fatigue, sleep disturbances and pain in individuals hospitalized with physical injuries after two terror attacks in Oslo in 2011, approximately three years after the events. A secondary aim was to explore the relationship between these outcomes and medical and psychosocial factors.

Materials And Methods: Thirty of 43 potential persons participated. Read More

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http://dx.doi.org/10.1080/09638288.2019.1585489DOI Listing

Measuring Apoptosis and Necrosis in Cholestatic Liver Injury.

Methods Mol Biol 2019 ;1981:133-147

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.

Cholestasis can be induced by obstruction of bile ducts or intrahepatic toxicity of drugs and chemicals. However, the mode of cell death during cholestasis, i.e. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_9DOI Listing
January 2019

Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis.

Methods Mol Biol 2019 ;1981:25-53

Department of Systems Toxicology, Leibniz Research Centre for Working Environment and Human Factors (IfADo) at TU Dortmund, Dortmund, Germany.

Cholestasis, the impairment of bile flux out of the liver, is a common complication of many pathological liver disorders, such as cholangiopathies, primary biliary sclerosis, and primary biliary cirrhosis. Besides accumulation of bile acids in the liver and blood, it leads to a proliferative response of the biliary tree termed as a ductular reaction. The ductular reaction is characterized by enhanced proliferation of cholangiocytes, which form the epithelial lining of bile ducts. Read More

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http://link.springer.com/10.1007/978-1-4939-9420-5_3
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http://dx.doi.org/10.1007/978-1-4939-9420-5_3DOI Listing
January 2019
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Prognostic significance of C-reactive protein to albumin ratio in colorectal cancer patients: a meta-analysis.

Int J Colorectal Dis 2019 Apr 23. Epub 2019 Apr 23.

Department of Digestive Disease, Central Hospital of Shanghai Qingpu District, No. 1158 East Road, Qingpu District, Shanghai, 201700, People's Republic of China.

Purpose: Inconsistent results on the prognostic significance of C-reactive protein to albumin ratio (CAR) in colorectal cancer patients have been reported. This meta-analysis sought to assess the prognostic value of pretreatment CAR for survival outcomes in colorectal cancer patients.

Methods: We conducted a systematic literature search of PubMed and Embase databases until February 16, 2019. Read More

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http://dx.doi.org/10.1007/s00384-019-03299-xDOI Listing

NHL Pathological Image Classification Based on Hierarchical Local Information and GoogLeNet-Based Representations.

Biomed Res Int 2019 21;2019:1065652. Epub 2019 Mar 21.

School of Science and Technology, Nottingham Trent University, Nottingham, UK.

Background: Accurate classification for different non-Hodgkin lymphomas (NHL) is one of the main challenges in clinical pathological diagnosis due to its intrinsic complexity. Therefore, this paper proposes an effective classification model for three types of NHL pathological images, including mantle cell lymphoma (MCL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL).

Methods: There are three main parts with respect to our model. Read More

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http://dx.doi.org/10.1155/2019/1065652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448331PMC

Stretched Penile Length and Testicular Size from Birth to 18 Years in Boys from Western Maharashtra.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):3-8

Department of Growth and Pediatric Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.

Background: Genital stage and testicular volume examination and assessment are essential for assessment of growth puberty in boys. There is paucity of Indian data for penile and testicular parameters particularly in pubertal years.

Aim: The aim of this study is to present normative data for penile length, testicular volume, and testicular length from birth to 18 years in boys from western Maharashtra and to correlate these parameters with sexual maturity staging (SMR) (Tanner staging). Read More

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http://dx.doi.org/10.4103/ijem.IJEM_242_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446671PMC

Comorbidity of Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Disease Exert Significant Effect on RBC Indices.

Anemia 2019 19;2019:3179173. Epub 2019 Mar 19.

Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P. O. Box KB 143, Korle-Bu, Accra, Ghana.

Background: Glucose-6-phosphate dehydrogenase (G6PD) converts glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway and protects red blood cells (RBCs) from oxidative damage. Their deficiency therefore makes RBCs prone to haemolysis. Sickle cell disease (SCD) on the other hand is a hereditary blood disorder in which there is a single nucleotide substitution in the codon for amino acid 6 substituting glutamic acid with valine. Read More

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http://dx.doi.org/10.1155/2019/3179173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444271PMC

Effectiveness of hand hygiene practices in preventing influenza virus infection in the community setting: A systematic review.

Can Commun Dis Rep 2019 Jan 3;45(1):12-23. Epub 2019 Jan 3.

Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON.

Background: Hand hygiene is known to be an effective infection prevention and control measure in health care settings. However, the effectiveness of hand hygiene practices in preventing influenza infection and transmission in the community setting is not clear.

Objective: To identify, review and synthesize available evidence on the effectiveness of hand hygiene in preventing laboratory-confirmed or possible influenza infection and transmission in the community setting. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
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http://dx.doi.org/10.14745/ccdr.v45i01a02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461122PMC
January 2019
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Summary of the NACI literature review on the comparative effectiveness of subunit and split virus inactivated influenza vaccines in older adults.

Authors:
I Gemmill K Young

Can Commun Dis Rep 2018 Jun 7;44(6):129-133. Epub 2018 Jun 7.

Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON.

Background: Subunit and split virus inactivated influenza vaccines (IIV) are two commonly used types of seasonal influenza vaccines in Canada. The comparative effectiveness of these two formulations is particularly relevant for older adults, as older adults have reduced influenza vaccine effectiveness and experience more severe influenza than younger adults.

Objective: To compare the vaccine effectiveness and immunogenicity of unadjuvanted, standard-dose subunit IIVs versus unadjuvanted, standard-dose split virus IIVs in adults 65 years of age and older. Read More

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[Alitretinoin (Toctino): A French follow-up study of harmacovigilance].

Therapie 2019 Mar 31. Epub 2019 Mar 31.

Centre régional de pharmacovigilance, centre-Val-de-Loire, service de pharmacosurveillance, CHRU de Tours, 37044 Tours, France. Electronic address:

Introduction: The adverse reaction profile of alitretinoin, a retinoid indicated in severe topical corticosteroid-refractory chronic hand eczema, is similar to that of other oral retinoids, especially isotretinoin. The objective of this study was to detect new adverse effects (not listed) of alitretinoin and to estimate the number of pregnancies exposed.

Material And Methods: All cases of ADR reported in France with alitretinoin between October 1st, 2012 and February 29th, 2016 were analysed. Read More

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http://dx.doi.org/10.1016/j.therap.2019.02.006DOI Listing
March 2019
1 Read

Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial.

J Orthop Surg Res 2019 Apr 23;14(1):109. Epub 2019 Apr 23.

Regenerative Medicine, BioCruces Health Research Institute, Cruces University Hospital, 48903, Barakaldo, Spain.

Objectives: To determine the efficacy of platelet-rich plasma (PRP) compared to lidocaine as a tenotomy adjuvant for people with elbow tendinopathy.

Methods: Our study was a parallel-group, double-blind, randomized trial involving 71 patients with recalcitrant elbow tendinopathy who received two sessions of ultrasound-guided tenotomy with either PRP or lidocaine in a tertiary public hospital. The primary end point was the percentage of patients with an improvement exceeding 25% reduction in disability (Spanish version of the Disabilities of the Arm, Shoulder and Hand questionnaires-DASH-E) at 6 and 12 months; the secondary outcome was the percentage of patients exceeding 25% reduction in pain (VAS-P). Read More

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http://dx.doi.org/10.1186/s13018-019-1153-6DOI Listing

Priorities and challenges for health leadership and workforce management globally: a rapid review.

BMC Health Serv Res 2019 Apr 24;19(1):239. Epub 2019 Apr 24.

School of Public Health and Community Medicine, University of New South Wales, UNSW, Sydney, 2052, Australia.

Background: Health systems are complex and continually changing across a variety of contexts and health service levels. The capacities needed by health managers and leaders to respond to current and emerging issues are not yet well understood. Studies to date have been country-specific and have not integrated different international and multi-level insights. Read More

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http://dx.doi.org/10.1186/s12913-019-4080-7DOI Listing

Silas Weir Mitchell, MD, LLD, FRC: Neurological Evaluation and Rehabilitation of the Injured Upper Extremity.

Hand (N Y) 2019 Apr 23:1558944719843643. Epub 2019 Apr 23.

1 Johns Hopkins University, Baltimore, MD, USA.

Appreciating the history of Hand Surgery is part of what most of us enjoy about our profession. Most of us know that Silas Weir Mitchell, MD, coined the terms "Causalgia" and "Phantom Limb," yet few of us know that our present-day evaluation of the sensory and motor function of the hand and some of our rehabilitation methods for motor palsy were introduced by Mitchell as he worked, scholarly, in Turner's Lane Hospital, the first hospital devoted to nerve injuries, to understand Civil War gunshot wounds related to musket ball. Mitchell's contributions to neurosensory and motor evaluation were reviewed by reading his historical publications. Read More

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http://dx.doi.org/10.1177/1558944719843643DOI Listing

Brachioradialis Flap With Vascularized Lateral Ulnar Collateral Ligament Reconstruction: A Case Report.

Hand (N Y) 2019 Apr 23:1558944719843632. Epub 2019 Apr 23.

1 University of Southern California, Los Angeles, USA.

Background: Soft tissue defects about the elbow with concurrent ligamentous instability can be challenging to treat.

Methods: We present a case report of a lateral elbow wound that resulted in lateral ulnar collateral ligament deficiency and posterolateral elbow instability.

Results: We describe our technique of a modified brachioradialis rotational flap, in which the muscle is rotated to cover the soft tissue defect, while the vascularized brachioradialis tendon is used to simultaneously reconstruct the lateral ulnar collateral ligament. Read More

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http://dx.doi.org/10.1177/1558944719843632DOI Listing

Comparing the Effect of Different Management and Rearing Systems on Pigeon Squab Welfare and Performance after the Loss of One or Both Parents.

Animals (Basel) 2019 Apr 14;9(4). Epub 2019 Apr 14.

Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medic, Zagazig University, Zagazig, Ash Sharqia Governorate 44519, Egypt.

Pigeon squabs completely depend on their parents for care and nourishment. The loss of one or both parents affects squabs' successful fledging. This study was carried out on young squabs to compare the effect of pigeon parent sex and different fostering methods on squab welfare (behavior and growth performance). Read More

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http://dx.doi.org/10.3390/ani9040165DOI Listing

Intercomparison of Soil Moisture Retrieved from GNSS-R and from Passive L-Band Radiometry at the Valencia Anchor Station.

Sensors (Basel) 2019 Apr 22;19(8). Epub 2019 Apr 22.

School of Electronic and Information Engineering, Beihang University, Beijing 100083, China.

In this paper, the SOMOSTA (Soil Moisture Monitoring Station) experiment on the intercomparison of soil moisture monitoring from Global Navigation Satellite System Reflectometry (GNSS-R) signals and passive L-band microwave radiometer observations at the Valencia Anchor Station is introduced. The GNSS-R instrument has an up-looking antenna for receiving direct signals from satellites, and a dual-pol down-looking antenna for receiving LHCP (left-hand circular polarization) and RHCP (right-hand circular polarization) reflected signals from the soil surface. Data were collected from the three different antennas through the two channels of Oceanpal GNSS-R receiver and, in addition, calibration was performed to reduce the impact from the differing channels. Read More

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http://dx.doi.org/10.3390/s19081900DOI Listing

Using Surgeon Hand Motions to Predict Surgical Maneuvers.

Hum Factors 2019 Apr 23:18720819838901. Epub 2019 Apr 23.

University of Wisconsin-Madison, USA.

Objective: This study explores how common machine learning techniques can predict surgical maneuvers from a continuous video record of surgical benchtop simulations.

Background: Automatic computer vision recognition of surgical maneuvers (suturing, tying, and transition) could expedite video review and objective assessment of surgeries.

Method: We recorded hand movements of 37 clinicians performing simple and running subcuticular suturing benchtop simulations, and applied three machine learning techniques (decision trees, random forests, and hidden Markov models) to classify surgical maneuvers every 2 s (60 frames) of video. Read More

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http://dx.doi.org/10.1177/0018720819838901DOI Listing

Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis.

PLoS One 2019 23;14(4):e0215840. Epub 2019 Apr 23.

Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.

Scope: Studies have demonstrated inconsistent effects of curcumin on glycemic outcomes and lipid parameters in patients with prediabetes and type 2 diabetes mellitus (T2DM). This study aimed to assess the effect of curcumin on glycemic control and lipid profile in prediabetes and T2DM.

Methods And Results: A systematic search of randomized controlled trials (RCTs) was conducted from inception to June 2018 in electronic sources including AMED, ANZCTR, BioMed Central, CENTRAL, CINAHL, ClinicalTrials. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215840PLOS

Systematic Review of Validated Quality of Life and Swallow Outcomes after Transoral Robotic Surgery.

Otolaryngol Head Neck Surg 2019 Apr 23:194599819844755. Epub 2019 Apr 23.

1 Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, School of Medicine, Southern Illinois University, Springfield, Illinois, USA.

Objective: To systematically review the available evidence on the effects of transoral robotic surgery (TORS) on the posttreatment quality of life (QOL) and swallow function of patients with head and neck cancer.

Data Sources: PubMed and Ovid electronic databases were searched from inception to July 6, 2016. Specific database functions were applied to maximize the search. Read More

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http://dx.doi.org/10.1177/0194599819844755DOI Listing

Preoperative MRI Shoulder Findings Associated with Clinical Outcome 1 Year after Rotator Cuff Repair.

Radiology 2019 Apr 23:181718. Epub 2019 Apr 23.

From the Departments of Radiology (R.K., P.T., D.B., F.L., M.T.), Orthopedic Surgery (T.M.), and Biostatistics (G.L.), University of Wisconsin School of Medicine and Public Health, Clinical Science Center, E3/311, 600 Highland Ave, Madison, WI 53792-3252.

Background Investigation of the use of preoperative MRI for providing prognostic information regarding clinical outcome following rotator cuff repair has been limited. Purpose To determine whether patients with more severe rotator cuff tears of the shoulder at preoperative MRI have a greater degree of residual pain and disability after rotator cuff repair. Materials and Methods This retrospective study included a cohort of 141 patients who underwent surgical repair of a full-thickness rotator cuff tear at a single institution between April 16, 2012, and September 3, 2015. Read More

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http://dx.doi.org/10.1148/radiol.2019181718DOI Listing

Using simple interrupted Suture Anastomoses may impair Translatability of experimental Rodent oesophageal Surgery.

Acta Chir Belg 2019 Apr 23:1-14. Epub 2019 Apr 23.

b Department of Paediatric Surgery , Universitätsmedizin Mainz der Johannes Gutenberg-Universität , Langenbeckstraße 1 , D-55131 Mainz , Germany.

Background/purpose: Irreproducibility and missing translatability are major drawbacks in experimental animal studies. Hand-sewn anastomoses in oesophageal surgery are usually continuous, whereas those in experimental oesophageal surgery are widely performed using the simple interrupted technique. It has been implicated to be inferior in tolerating anastomotic tension, which we aimed to test in rats due to their importance as an animal model in oesophageal surgery. Read More

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[Express]A Novel Neuromodulation Strategy to Enhance the Prefrontal Control to Treat Pain.

Mol Pain 2019 Apr 23:1744806919845739. Epub 2019 Apr 23.

New York University Langone Medical Center.

Effective pharmacological treatment options for chronic pain remain very limited, and continued reliance on opioid analgesics has contributed to an epidemic in the U.S. On the other hand, non-pharmacologic neuromodulatory interventions provide a promising avenue for relief of chronic pain without the complications of dependence and addiction. Read More

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http://dx.doi.org/10.1177/1744806919845739DOI Listing

From disability to human flourishing: how fourth wave psychotherapies can help to reimagine rehabilitation and medicine as a whole.

Disabil Rehabil 2019 Apr 23:1-7. Epub 2019 Apr 23.

c Department of Psychiatry, Brigham And Women's Hospital , Harvard Medical School , Boston , MA , USA.

Aim: With disabled patients, clinicians are often mechanistically oriented, limiting goals to bodily improvements of perceived deficits back to species-typical functioning. Psychological goals, when present at all, are often pessimistically narrow, or phenomenologically shallow. Recent research on fourth wave psychotherapies helps broaden clinical concepts of healing and treatment beyond mere deficit remediation, and helps match clinical goals with the richness of human flourishing and the layered complexity of the patient's evolving experience of meaning. Read More

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http://dx.doi.org/10.1080/09638288.2019.1602674DOI Listing

High-field mr diffusion-weighted image denoising using a joint denoising convolutional neural network.

J Magn Reson Imaging 2019 Apr 22. Epub 2019 Apr 22.

Human Phenome Institute, Fudan University, Shanghai, China.

Background: Low signal-to-noise ratio (SNR) has been a major limiting factor for the application of higher-resolution diffusion-weighted imaging (DWI). Most of the conventional denoising models suffer from the drawbacks of shallow feature extraction and hand-crafted parameter tuning. Although multiple studies have shown the promising applications of image denoising using convolutional neural networks (CNNs), none of them have considered denoising multiple b-value DWIs using a multichannel CNN model. Read More

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http://dx.doi.org/10.1002/jmri.26761DOI Listing