10,089 results match your criteria Techniques in Ophthalmology [Journal]


Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study.

BMC Ophthalmol 2019 Feb 15;19(1):52. Epub 2019 Feb 15.

Glaucoma Service, Department of Ophthalmology, Federal University of São Paulo, Rua Botucatu, 821, Vila Clementino, São Paulo, 04021-001, Brazil.

Background: To investigate structural and functional correlations in glaucoma patients using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)-derived parameters.

Methods: We prospectively enrolled healthy participants and glaucomatous patients with a wide range of disease stages. All participants underwent visual field (VF) testing (SITA - Standard 24-2; Carl Zeiss Meditec, Dublin, CA) and EDI OCT imaging (Spectralis; Heidelberg Engineering Co. Read More

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http://dx.doi.org/10.1186/s12886-019-1054-9DOI Listing
February 2019

Medicare incentive payments to U.S. ophthalmologists for use of electronic health records: 2011-2016.

Ophthalmology 2019 Feb 12. Epub 2019 Feb 12.

Department of Ophthalmology, University of Washington, Seattle, Washington.

Purpose: To investigate ophthalmologists' rate of attestation to meaningful use (MU) of their electronic health record (EHR) systems in the Medicare EHR Incentive Program and their continuity and success in receiving payments in comparison with other specialties.

Design: Administrative database study.

Participants: Eligible professionals participating in the Medicare EHR Incentive Program. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.030DOI Listing
February 2019

Migraine and increased risk of developing open angle glaucoma: a population-based cohort study.

BMC Ophthalmol 2019 Feb 13;19(1):50. Epub 2019 Feb 13.

Department of Ophthalmology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan.

Background: Migraine is linked to endothelial dysfunction and is considered to be a systemic vasculopathy. Interestingly, systemic vascular diseases also occur in glaucoma patients and are considered to be vascular risk factors. Whether migraine is simply a concomitant condition in glaucoma patients or a risk factor per se for glaucoma remains unknown. Read More

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http://dx.doi.org/10.1186/s12886-019-1062-9DOI Listing
February 2019

Comparing habitual and i. Scription refractions.

BMC Ophthalmol 2019 Feb 12;19(1):49. Epub 2019 Feb 12.

Midwestern University, College of Optometry, 19555 N 59th Ave, Glendale, Arizona, 85308, USA.

Background: Many patients voice concerns regarding poor night vision, even when they see 20/20 or better in the exam room. During mesopic and scotopic conditions the pupil size increases, increasing the effects on visual performance of uncorrected (residual) refractive errors. The i. Read More

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http://dx.doi.org/10.1186/s12886-019-1053-xDOI Listing
February 2019

Development of a core outcome set for amblyopia, strabismus and ocular motility disorders: a review to identify outcome measures.

BMC Ophthalmol 2019 Feb 8;19(1):47. Epub 2019 Feb 8.

Department of Health Services Research, University of Liverpool, Waterhouse Building Block B, 2nd Floor, 1-3 Brownlow Street, L69 3GL, Liverpool, UK.

Background: Core Outcome Sets (COS) are defined as the minimum sets of outcomes that should be measured and reported in all randomised controlled trials to facilitate combination and comparability of research. The aim of this review is to produce an item bank of previously reported outcome measures from published studies in amblyopia, strabismus and ocular motility disorders to initiate the development of COS.

Methods: A review was conducted to identify articles reporting outcome measures for amblyopia, strabismus and ocular motility disorders. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-019-1055-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368710PMC
February 2019
4 Reads

Ciliochoroidal detachment after Ahmed glaucoma valve implantation: a retrospective study.

BMC Ophthalmol 2019 Feb 6;19(1):46. Epub 2019 Feb 6.

Affiliated Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Zhejiang, China.

Background: To investigate the occurrence of ciliochoroidal detachment (CCD), its risk factors and its impact on the success rate after Ahmed glaucoma valve (AGV) implantation.

Methods: This is a retrospective observational study carried out at Eye Hospital of Wenzhou Medical University, Zhejiang, China. Patients with uncontrolled glaucoma who underwent AGV implantation alone or combined with phacoemulsification (AGV-Phaco) in the hospital from April 1, 2013 to July 31, 2016 were included. Read More

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http://dx.doi.org/10.1186/s12886-019-1060-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368733PMC
February 2019
1.075 Impact Factor

Comparison of visual quality after EVO-ICL implantation and SMILE to select the appropriate surgical method for high myopia.

BMC Ophthalmol 2019 Feb 8;19(1):21. Epub 2019 Feb 8.

Department of Ophthalmology, Jinling Medical School of Nanjing Medical University, No. 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China.

Background: This study sought to compare the visual quality between intraocular collamer lens (EVO-ICL) implantation and small-incision lenticule extraction (SMILE) and determine the appropriate surgical method to treat patients with high myopia (- 6.25 to - 10 D).

Methods: A total of 48 eyes underwent EVO-ICL implantation and another 48 eyes underwent SMILE. Read More

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http://dx.doi.org/10.1186/s12886-019-1029-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367781PMC
February 2019

Agreement and Predictors of Discordance of Six Visual Field Progression Algorithms.

Ophthalmology 2019 Feb 4. Epub 2019 Feb 4.

Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD.

Purpose: To determine the agreement of six established visual field progression algorithms in a large dataset of visual fields from multiple institutions and to determine predictors of discordance amongst these algorithms.

Design: Retrospective Longitudinal Cohort Subjects, Participants, and/or Controls: Visual fields from five major eye care institutions in the United States. This analysis included a subset of eyes with at least five SITA-Standard 24-2 visual fields that met our reliability criteria. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.029DOI Listing
February 2019

Retinal and choroidal thickness in paediatric patients with hypoalbuminaemia caused by nephrotic syndrome.

BMC Ophthalmol 2019 Feb 6;19(1):44. Epub 2019 Feb 6.

Department of Ophthalmology, Peking University Frist Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Background: A study was conducted to evaluate the choroidal thickness (CT) and retinal thickness (RT) in paediatric patients with hypoalbuminaemia caused by nephrotic syndrome (NS). We also studied the correlation between the subfoveal choroidal thickness (SFCT) and serum protein concentration.

Methods: This was a cross-sectional study. Read More

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http://dx.doi.org/10.1186/s12886-019-1050-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364472PMC
February 2019
1 Read

Combined phacoemulsification and viscocanalostomy with Ologen implant versus combined phacoemulsification and viscocanalostomy.

BMC Ophthalmol 2019 Feb 6;19(1):45. Epub 2019 Feb 6.

Ophthalmology Department, Zagazig University, Zagazig, 44511, Egypt.

Background: To study the efficacy of the biodegradable collagen implant Ologen® as an adjuvant in phaco-viscocanalostomy in patients with coexisting cataract and primary open angle glaucoma.

Methods: This prospective, interventional, randomized clinical study was done at Alpha Vision Center, Zagazig, Egypt. Patients with coexisting cataract and glaucoma were randomized to receive either phaco-viscocanalostomy (Phacovisco group) (39 eyes) or phaco-viscocanalostomy with Ologen® implant (OloPhacovisco group) (40 eyes). Read More

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http://dx.doi.org/10.1186/s12886-019-1049-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364460PMC
February 2019
1.075 Impact Factor

Evaluation of the antioxidant effects of different histone deacetylase inhibitors (HDACis) on human lens epithelial cells (HLECs) after UVB exposure.

BMC Ophthalmol 2019 Feb 4;19(1):42. Epub 2019 Feb 4.

Eye Institute, Eye and Ear, Nose, and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China.

Background: To compare the protective effects of the histone deacetylase inhibitors (HDACis) β-hydroxybutyrate (βOHB), trichostatin A (TSA), suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) on human lens epithelial cells(HLECs) following ultraviolet-B (UVB) exposure.

Methods: HLECs were divided into subgroups: four HDACi groups, a control group, a UVB-treated group and a DMSO group (cells treated with DMSO and UVB irradiation). In the HDACi groups, HLECs were cultured with different concentrations of HDACis 12 h prior to UVB irradiation. Read More

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http://dx.doi.org/10.1186/s12886-019-1056-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360693PMC
February 2019
1 Read

Posterior capsular opacification comparison between morphology and objective visual function.

BMC Ophthalmol 2019 Feb 4;19(1):40. Epub 2019 Feb 4.

Tianjin Eye Hospital, No.4 Gansu Road, Heping District, Tianjin, 300020, China.

Background: To compare the influence of posterior capsule opacification (PCO) morphology and severity on intraocular stray light and visual function with different levels of contrast.

Methods: Forty-five patients diagnosed with PCO were included in this prospective consecutive case series. The Optical Quality Analysis System II (OQAS II) was adopted to assess the objective visual function including objective scatter index (OSI) and optical quality analysis system values (OVs) with 100, 20, and 9% contrast. Read More

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http://dx.doi.org/10.1186/s12886-019-1051-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360676PMC
February 2019

Safety and efficacy of wiping lid margins with lid hygiene shampoo using the "eye brush", a novel lid hygiene item, in healthy subjects: a pilot study.

BMC Ophthalmol 2019 Feb 4;19(1):41. Epub 2019 Feb 4.

Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: To evaluate the safety and efficacy of using a lid hygiene brush prototype to wipe the lid margins with lid hygiene shampoo in subjects with normal meibomian glands.

Methods: Twelve eyes of 6 subjects were all evaluated just before and after wiping lid margins using 1) tap water alone, 2) Eye Shampoo, 3) Eye Brush, or 4) both products, each during a different week. The results after using both products twice daily for 1 month were also evaluated. Read More

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http://dx.doi.org/10.1186/s12886-019-1052-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360667PMC
February 2019

Expression of matrix Metalloproteinases-2 and aquaporin-1 in corneoscleral junction after angle-closure in rabbits.

BMC Ophthalmol 2019 Feb 4;19(1):43. Epub 2019 Feb 4.

Department of Ophthalmology, Weifang Eye Hospital, Weifang, Shandong, People's Republic of China.

Background: To investigate the expression of Matrix Metalloproteinases 2 and aquaporin-1 in corneoscleral junction and explore the mechanism of trabecular damageafter angle-closure.

Methods: Thirty New Zealand white rabbits were randomly assigned into 2 groups, theexperimental group (Group 1) including twenty five rabbits and the control group (Group 2) including 5 rabbits. The rabbits in the experimental group were used to establish angle-closure models, and the rabbits in the control group were not subjected to any operation. Read More

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http://dx.doi.org/10.1186/s12886-019-1058-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360660PMC
February 2019
1 Read

Autologous Retinal Transplant For Refractory Macular Holes: Multicenter International Collaborative Study Group.

Ophthalmology 2019 Jan 31. Epub 2019 Jan 31.

Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Associated Retinal Consultants, Royal Oak, MI.

Purpose: To report the structural and functional outcomes of the autologous neurosensory retinal transplant for closure of refractory large macular holes.

Design: Multicenter retrospective consecutive case series PARTICIPANTS: Forty-one eyes of 41 patients (27 female and 14 male) with a full thickness macular hole refractory to prior vitrectomy with internal limiting membrane peel and tamponade.

Methods: All patients underwent pars-plana vitrectomy, autologous neurosensory retinal transplant with either gas, silicone oil tamponade, or short-term Perfluoro-n-octane heavy-liquid tamponade. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.027DOI Listing
January 2019
1 Read

Evidence of Müller Glial Dysfunction in Patients with Aquaporin-4 Immunoglobulin G-Positive Neuromyelitis Optica Spectrum Disorder.

Ophthalmology 2019 Jan 31. Epub 2019 Jan 31.

Save Sight Institute, The University of Sydney, NSW, Australia; Department of Health and Medical Sciences, Macquarie University, NSW, Australia; Sydney Neuroimaging Analysis Centre, NSW, Australia.

Purpose: To compare functional and structural changes in the retina in patients with aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS).

Design: Cross-sectional study; biochemical study of human retinas.

Participants: A total of 181 participants, including 22 consecutive patients (44 eyes) with NMOSD, 131 patients (262 eyes) with multiple sclerosis (MS), and 28 normal subjects (56 eyes). Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.016DOI Listing
January 2019
1 Read

Imageology features of different types of multifocal choroiditis.

BMC Ophthalmol 2019 Feb 1;19(1):39. Epub 2019 Feb 1.

Department of Ophthalmology, The Second People's Hospital of Yunnan Province, No.176 Qingnian Rd, Kunming, 650021, Yunnan, People's Republic of China.

Background: Multifocal choroiditis (MFC) is multi-inflammatory lesions that occur in the retinal pigment epithelium (RPE) and the choriocapillaris. Optical examinations are the major diagnostic methods to diagnose the disease.

Objective: To examine patients with different types of MFC by multiple imageological methods. Read More

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http://dx.doi.org/10.1186/s12886-019-1045-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359807PMC
February 2019

Eye diseases: the neglected health condition among urban slum population of Dhaka, Bangladesh.

BMC Ophthalmol 2019 Jan 31;19(1):38. Epub 2019 Jan 31.

BRAC James P Grant School of Public Health, BRAC University, Dhaka, Bangladesh.

Introduction: Globally, eye diseases are considered as one of the major contributors of nonfatal disabling conditions. In Bangladesh, 1.5% of adults are blind and 21. Read More

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http://dx.doi.org/10.1186/s12886-019-1043-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357461PMC
January 2019
1 Read
1.075 Impact Factor

Impact of vision loss on health-related quality of life in Trinidad and Tobago.

Ophthalmology 2019 Jan 28. Epub 2019 Jan 28.

Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Purpose: To determine whether distance vision impairment (VI) (Logarithm of the Minimum Angle of Resolution (LogMAR) >0.30), or near VI (NVI) (LogMAR 0.32 to 1. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.023DOI Listing
January 2019

Optical Coherence Tomography-based Diagnostic Criteria for Different Stages of Myopic Maculopathy.

Ophthalmology 2019 Jan 28. Epub 2019 Jan 28.

Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

Purpose: To analyze the choroidal thickness (CT) of each type of myopic maculopathy, and to establish an OCT-based classification of myopic maculopathy.

Design: Retrospective, hospital-based, cross-sectional study.

Participants: Highly myopic (HM) eyes that were examined by swept-source OCT. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.012DOI Listing
January 2019

A Clinical Phase 2 Study to Assess Efficacy, Safety and Tolerability of CyclASol for Treatment of Dry Eye Disease (DED).

Ophthalmology 2019 Jan 28. Epub 2019 Jan 28.

Novaliq GmbH, Heidelberg, Germany.

Purpose: To compare the efficacy, safety and tolerability of CyclASol at two concentrations (0.1% and 0.05% of cyclosporine [CsA]) to vehicle when applied twice daily for 16 weeks in patients with Dry Eye Disease (DED). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420183213
Publisher Site
http://dx.doi.org/10.1016/j.ophtha.2019.01.024DOI Listing
January 2019
2 Reads

A comparison of pediatric ocular injuries based on intention in patients admitted with trauma.

BMC Ophthalmol 2019 Jan 29;19(1):37. Epub 2019 Jan 29.

Department of Ophthalmology & Visual Sciences, Montefiore Medical Center/Albert Einstein College of Medicine, 3332 Rochambeau Avenue, 3rd floor Ophthalmology Offices, Bronx, NY, 10467, USA.

Purpose: Pediatric ocular trauma is a major source of morbidity and blindness and the number of epidemiological studies is incommensurate with its significance. We sought to determine differences in epidemiologic patterns of pediatric ocular injuries based on intention.

Methods: A retrospective review of the National Trauma Data Bank (2008-2014) was performed and patients < 21 years old, admitted with trauma and ocular injury, were identified using ICD-9CM codes. Read More

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http://dx.doi.org/10.1186/s12886-018-1024-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352334PMC
January 2019

Comparison of face-down posturing with nonsupine posturing after macular hole surgery: a meta-analysis.

BMC Ophthalmol 2019 Jan 28;19(1):34. Epub 2019 Jan 28.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Background: A few randomized controlled trials (RCTs) have evaluated face-down posturing (FDP) with the far less physically challenging nonsupine posturing (NSP) in the treatment of idiopathic full-thickness macular holes (MHs). The objective of our study was to evaluate the efficacy of postoperative posturing on the anatomical and functional outcomes of MH surgery.

Methods: The PubMed, Embase, and Cochrane Central Register of Controlled Trials databases were searched from their earliest entries through December 2016 to identify the studies that had evaluated the effects of postoperative posturing with FDP or NSP for patients with MH surgery. Read More

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http://dx.doi.org/10.1186/s12886-019-1047-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348675PMC
January 2019

Posterior pole asymmetry analysis and retinal nerve fibre layer thickness measurements in primary angle-closure suspect patients.

BMC Ophthalmol 2019 Jan 28;19(1):36. Epub 2019 Jan 28.

Department of Ophthalmology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.

Purpose: To measure peripapillary retinal nerve fiber layer (RNFL) thickness and posterior pole retinal thickness in primary angle-closure suspects (PACS) by Spectral domain optical coherence tomography (SD-OCT) and to be compared with normal subjects.

Methods: Thirty five primary angle-closure suspect patients and thirty normal subjects were enrolled in this study. Peripapillary RNFL and posterior pole retinal thickness by posterior pole asymmetry analysis (PPAA) in SD-OCT were measured. Read More

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http://dx.doi.org/10.1186/s12886-019-1034-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350334PMC
January 2019

Efficacy and safety of a novel naltrexone treatment for dry eye in type 1 diabetes.

BMC Ophthalmol 2019 Jan 28;19(1):35. Epub 2019 Jan 28.

Department of Neural and Behavioral Science, The Pennsylvania State University College of Medicine, MC H109, 500 University Drive, Hershey, PA, 17033-0850, USA.

Background: Dry eye disease (DED) is a prevalent complication of diabetes and presents as reduced tear production and/or increased corneal surface sensitivity often with secondary ocular surface changes. This study examined the safety and efficacy of a proprietary new eye drop formulation for topical treatment of DED.

Methods: Type 1 diabetes (T1D) was established in male Sprague-Dawley rats to study the efficacy and safety of the investigational compound that contained 20 μg/ml of naltrexone (NTX). Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
Publisher Site
http://dx.doi.org/10.1186/s12886-019-1044-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348650PMC
January 2019
2 Reads
1.075 Impact Factor

Three-year Observation of Children Age 3 to 10 Years Old with Untreated Intermittent Exotropia.

Ophthalmology 2019 Jan 25. Epub 2019 Jan 25.

Jaeb Center for Health Research, Tampa, FL.

Purpose: To describe the course of intermittent exotropia (IXT) in children followed without treatment for three years DESIGN: Observation arm from randomized trial of short-term occlusion vs. observation PARTICIPANTS: 183 children 3 to 10 years old with previously untreated IXT and 400 arcsec or better near stereoacuity METHODS: Participants were to receive no treatment unless deterioration criteria were met at a follow-up visit occurring at 3 months, 6 months, or 6-month intervals thereafter for 3 years MAIN OUTCOME MEASURES: The primary outcome was deterioration by 3 years, defined as meeting motor criterion (constant XT ≥10 prism diopters (Δ) at distance and near) or near stereoacuity criterion (≥ 2 octaves decrease from best previous measure). For the primary analysis, participants also were counted as deteriorated if treatment was prescribed without meeting either deterioration criterion. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.015DOI Listing
January 2019

Plus Disease in the Telemedicine Approaches to Evaluating of Acute-Phase ROP (e-ROP) Study: Characteristics, Predictors and Accuracy of Image Grading.

Ophthalmology 2019 Jan 25. Epub 2019 Jan 25.

Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania. Electronic address:

Purpose: To describe characteristics and predictors of plus disease, and the accuracy of image grading for plus disease in the e-ROP Study.

Design: Secondary analyses of data from 13 North American centers.

Participants: Premature infants with birth weight (BW) <1251g. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.021DOI Listing
January 2019

Prevalence and risk factors of refractive error: a cross-sectional Study in Han and Yi adults in Yunnan, China.

BMC Ophthalmol 2019 Jan 25;19(1):33. Epub 2019 Jan 25.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifu Yuan, Dongcheng District, Beijing, 100730, China.

Background: Few studies have investigated the prevalence of refractive error (RE) in older adults in China, and most have focused on East China. Our study determined the prevalence and risk factors of RE in Han and Yi adults aged 40-80 years in rural and urban areas in Yunnan Province, Southwest China.

Methods: Our cross-sectional study is part of the China National Health Survey (CNHS). Read More

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http://dx.doi.org/10.1186/s12886-019-1042-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347814PMC
January 2019
6 Reads

Incidence of acute-onset endophthalmitis after separate bilateral cataract surgeries less than 5 days apart.

BMC Ophthalmol 2019 Jan 25;19(1):32. Epub 2019 Jan 25.

Department of Ophthalmology, Xi'an No. 4 Hospital, Shaanxi Eye Hospital, Affiliated Guangren Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.

Purpose: To assess the incidence of acute-onset endophthalmitis after separate bilateral cataract surgeries less than 5 days apart (SBCS5).

Methods: The medical records of all patients who underwent SBCS5 at a single medical center between October 10, 2012 and July 31, 2017 were retrospectively reviewed.

Results: The medical records for treatment of 5374 eyes of 2687 patients were examined. Read More

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http://dx.doi.org/10.1186/s12886-019-1028-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347771PMC
January 2019
6 Reads

Accuracy of swept-source optical coherence tomography based biometry for intraocular lens power calculation: a retrospective cross-sectional study.

BMC Ophthalmol 2019 Jan 24;19(1):30. Epub 2019 Jan 24.

Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: To evaluate the accuracy of biometric measurements by a swept-source optical coherence tomography (SS-OCT) based biometry for intraocular lens (IOL) power calculation.

Methods: This retrospective observational study enrolled 431 patients undergoing cataract surgery. The charts were reviewed to investigate the failure rate of axial length (AL) measurement of the SS-OCT biometer, partial coherence interferometry (PCI), and A-scan ultrasonography (US) according to cataract type and severity. Read More

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http://dx.doi.org/10.1186/s12886-019-1036-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346505PMC
January 2019
1 Read

Gender-differences in age-related changes of corneal astigmatism in Korean cataract patients.

BMC Ophthalmol 2019 Jan 24;19(1):31. Epub 2019 Jan 24.

Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Background: This cross-sectional study investigated age-related changes in anterior, posterior, and total corneal astigmatism and evaluated sex differences in corneal astigmatism with increasing age in cataract patients.

Methods: This study evaluated eyes with cataracts from May 2009 and July 2013. All eyes underwent a complete ophthalmological examination and corneal Scheimpflug imaging by a Pentacam camera (Oculus, Wetzlar, Germany). Read More

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http://dx.doi.org/10.1186/s12886-018-1001-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346567PMC
January 2019
1 Read

Canadian Treat and Extend Analysis Trial with Ranibizumab in Patients with Neovascular Age-related Macular Disease: 1-Year Results of the Randomized CANTREAT Study.

Ophthalmology 2019 Jan 21. Epub 2019 Jan 21.

Ivey Eye Institute, London, ON, Canada, Western University, London, ON, Canada.

Objective: To compare the efficacy of ranibizumab using a treat-and-extend (T&E) regimen to monthly dosing in treatment-naïve patients with neovascular age-related macular degeneration (nAMD).

Design: Prospective, randomized, open-label, multicenter, non-inferiority, post-authorization study.

Participants: Treatment-naïve patients with choroidal neovascularization secondary to AMD. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.013DOI Listing
January 2019
1 Read

HOXA9 is a novel myopia risk gene.

BMC Ophthalmol 2019 Jan 23;19(1):28. Epub 2019 Jan 23.

Center for Myopia and Eye Disease, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.

Purpose: A recent meta-analysis revealed PAX6 as a risk gene for myopia. There is a link between PAX6 and HOXA9. Furthermore, HOXA9 has been reported to activate TGF-β that is a risk factor for myopia. Read More

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http://dx.doi.org/10.1186/s12886-019-1038-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343304PMC
January 2019
1 Read

Agreement study between color and IR retinal images based on retinal vasculature morphological parameters.

BMC Ophthalmol 2019 Jan 21;19(1):27. Epub 2019 Jan 21.

School of Engineering, RMIT University, Melbourne, Australia.

Background: Color fundus photography have been extensively used to explore the link between retinal morphology changes associated with various disease i.e. Diabetic Retinopathy, Glaucoma. Read More

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http://dx.doi.org/10.1186/s12886-018-0997-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341663PMC
January 2019
1 Read

Differential expression of connective tissue growth factor and hepatocyte growth factor in the vitreous of patients with high myopia versus vitreomacular interface disease.

BMC Ophthalmol 2019 Jan 21;19(1):25. Epub 2019 Jan 21.

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.

Background: To determine the levels of connective tissue growth factor (CTGF) and hepatocyte growth factor (HGF) in the vitreous of patients with high myopia, in comparison with those with a vitreomacular interface disease (VMID).

Methods: Patients with either high myopia (high myopia group) or a VMID (VMID group) were included in this study. Each of the two groups were further subdivided into two subgroups: group A (high myopia with macular hole), group B (high myopia with macular retinoschisis), group C (idiopathic macular hole), and group D (idiopathic epiretinal membrane). Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-019-1041-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341692PMC
January 2019
3 Reads

Open globe and penetrating eyelid injuries from fish hooks.

BMC Ophthalmol 2019 Jan 21;19(1):26. Epub 2019 Jan 21.

Department of Ophthalmology, University Medical Center Schleswig-Holstein, Arnold-Heller Strasse 3, Haus 25, 24105, Kiel, Germany.

Background: A few case reports have described accidental eye injuries caused by fish hooks. The severity of ocular injuries is dependent on the involved ocular structures. Severe ocular injuries due to fish hooks are rare. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-019-1040-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341560PMC
January 2019
7 Reads

Changes in choroidal thickness and optic nerve head morphology after filtering surgery: nonpenetrating deep sclerectomy versus trabeculectomy.

BMC Ophthalmol 2019 Jan 21;19(1):24. Epub 2019 Jan 21.

Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, DHU Sight Restore, 28 rue de Charenton, 75012, Paris, France.

Background: The purpose of this study was to evaluate the changes in choroidal thickness and lamina cribrosa position after nonpenetrating deep sclerectomy (NPDS) and trabeculectomy.

Methods: Twenty-three eyes with glaucoma that required filtering surgery were included (12 NDPS and 11 trabeculectomies) in this prospective observational study. OCT-enhanced depth imaging (OCT-EDI) was used to measure choroidal thickness, prelaminar tissue thickness and lamina cribrosa position before and 7 days and 1 month after surgery. Read More

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http://dx.doi.org/10.1186/s12886-019-1031-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341643PMC
January 2019
2 Reads

Changes in EHR use time and documentation over the course of a decade.

Ophthalmology 2019 Jan 18. Epub 2019 Jan 18.

Department of Medical Informatics and Clinical Epidemiology Oregon Health & Science University Portland, Oregon. Electronic address:

Objective: With the current wide adoption of Electronic Health Records (EHRs) by ophthalmologists, there are widespread concerns about the amount of time spent using the EHR. The goal of this study was to examine how EHR use time as well as related documentation behaviors changed a decade after EHR adoption.

Design: Single center cohort study SUBJECTS: 685,361 office visits from 70 ophthalmology providers. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.011DOI Listing
January 2019
3 Reads

Long-term Visual Outcomes and Causes of Vision Loss in Chronic Central Serous Chorioretinopathy.

Ophthalmology 2019 Jan 16. Epub 2019 Jan 16.

Vitreous, Retina, Macula Consultants of New York, NY, USA; LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, NY, USA; Department of Ophthalmology, New York University School of Medicine, New York, NY, USA.

Purpose: To evaluate the long-term visual outcomes and causes of vision loss in chronic central serous chorioretinopathy (CSC).

Design: Retrospective, longitudinal study SUBJECTS: One-hundred and thirty-three subjects (217 eyes) with chronic CSC.

Methods: A retrospective review of clinical and multimodal imaging data of patients with chronic CSC managed by 3 of the authors between May 1977 and March 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420173206
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http://dx.doi.org/10.1016/j.ophtha.2018.12.048DOI Listing
January 2019
8 Reads

Lacrimal passage irrigation in children with Stevens-Johnson syndrome or toxic epidermal necrolysis: a five-year retrospective study.

BMC Ophthalmol 2019 Jan 18;19(1):22. Epub 2019 Jan 18.

Department of Ophthalmology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China.

Background: To identity the effect of lacrimal system irrigation in the acute stage in children with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).

Methods: A retrospective review of 39 patients with SJS or TEN from 2012 to 2017 was analyzed. Patients were divided into two subgroups according to whether they received irrigation in the acute stage. Read More

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http://dx.doi.org/10.1186/s12886-018-1014-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339389PMC
January 2019
3 Reads

All-trans retinoic acid stimulates the secretion of TGF-β2 via the phospholipase C but not the adenylyl cyclase signaling pathway in retinal pigment epithelium cells.

BMC Ophthalmol 2019 Jan 18;19(1):23. Epub 2019 Jan 18.

Department of Ophthalmology, The Third Xiangya Hospital, Central South, Changsha, Hunan, China.

Background: By investigating that (i) all-trans retinoic acid (ATRA) affects human retinal pigment epithelium (RPE) in expressing and secreting transforming growth factor (TGF)-β and (ii) U73122 (phospholipase C inhibitor) and SQ22536 (adenylyl cyclase inhibitor) regulate the ATRA-induced secretion of TGF-β in human RPE, we sought to interpret the signaling pathway of ATRA in promoting the development of myopia.

Methods: The RPE cell line (D407) was treated with (i) ATRA (10 μM), (ii) U73122 (5-40 μM) and ATRA (10 μM), or (iii) SQ22536 (5-40 μM) and ATRA (10 μM). The control group was no-treated. Read More

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http://dx.doi.org/10.1186/s12886-018-1017-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339369PMC
January 2019
2 Reads

The Oculome Panel Test: Next-Generation Sequencing to Diagnose a Diverse Range of Genetic Developmental Eye Disorders.

Ophthalmology 2019 Jan 14. Epub 2019 Jan 14.

UCL Great Ormond Street Institute of Child Health, and NIHR Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London, London, United Kingdom. Electronic address:

Purpose: To develop a comprehensive next-generation sequencing panel assay that screens genes known to cause developmental eye disorders and inherited eye disease and to evaluate its diagnostic yield in a pediatric cohort with malformations of the globe, anterior segment anomalies, childhood glaucoma, or a combination thereof.

Design: Evaluation of diagnostic test.

Participants: Two hundred seventy-seven children, 0 to 16 years of age, diagnosed with nonsyndromic or syndromic developmental eye defects without a genetic diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420183185
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http://dx.doi.org/10.1016/j.ophtha.2018.12.050DOI Listing
January 2019
7 Reads

Consecutive drilling combined with phaco chop for full thickness segmentation of very hard nucleus in coaxial microincisional cataract surgery.

BMC Ophthalmol 2019 Jan 16;19(1):20. Epub 2019 Jan 16.

Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, 325027, Zhejiang, China.

Background: The complete disassembly of nuclear is the most challenging step in hard cataract surgery through microincision. The classic phaco chop technique often does not succeed, resulting in incomplete nuclear segmentation. The authors describe a technique to improve the efficacy and safety of the initial chopping. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-019-1033-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335814PMC
January 2019
5 Reads

Evolution in the Risk of Cataract Surgical Complications among Patients Exposed to Tamsulosin: A Population-Based Study.

Ophthalmology 2019 Jan 12. Epub 2019 Jan 12.

Department of Ophthalmology, Queen's University, Kingston, Canada; Department of Ophthalmology, Kingston Health Sciences Centre, Hotel Dieu Hospital Site, Kingston, Canada.

Purpose: Tamsulosin is associated with intraoperative floppy iris syndrome (IFIS), an important risk factor for complications during cataract surgery. Significant efforts have been made to increase awareness of the risks associated with tamsulosin, and educational initiatives have fostered the uptake of technical adjustments to decrease adverse event rates among tamsulosin-exposed patients. However, the effectiveness of these efforts at the population level has not been studied. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420183117
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http://dx.doi.org/10.1016/j.ophtha.2018.11.028DOI Listing
January 2019
13 Reads

Clinical characteristics and prognostic factors of posterior segment intraocular foreign body in a tertiary hospital.

BMC Ophthalmol 2019 Jan 14;19(1):17. Epub 2019 Jan 14.

Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.

Background: To identify the clinical characteristics, prognostic factors and visual outcomes in posterior segment IOFBs patients managed by PPV in a tertiary hospital.

Methods: A retrospective chart review was performed for 56 patients, who had PPV for IOFBs removal between November 2013 and November 2015. The mechanisms of injury, the nature of the IOFBs, the BCVA before and after the surgery, the penetrating site and the complications of the surgery were all collected. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-1026-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332632PMC
January 2019
8 Reads

Simulating an Anti-Vascular Endothelial Growth Factor Switch in Neovascular Age-Related Macular Degeneration: A HARBOR Subanalysis.

Ophthalmology 2019 Jan 11. Epub 2019 Jan 11.

Genentech, Inc., South San Francisco, California.

Purpose: A simulated switching study assessed the effects of continuing the same anti-vascular endothelial growth factor (VEGF) treatment among patients who typically are considered for a therapy switch. Post hoc analysis of data from HARBOR was undertaken. Patients with neovascular age-related macular degeneration who demonstrated a suboptimal response after 3 or 6 months of ranibizumab treatment were identified as switching candidates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420183287
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http://dx.doi.org/10.1016/j.ophtha.2019.01.003DOI Listing
January 2019
3 Reads

Intravitreal dexamethasone implant Ozurdex® in naïve and refractory patients with different subtypes of diabetic macular edema.

BMC Ophthalmol 2019 Jan 11;19(1):15. Epub 2019 Jan 11.

University General Hospital of Valencia, Avenida Tres Cruces S/N, 46015, Valencia, Spain.

Background: Diabetic macular edema (DME) can be treated with different alternatives, among them Dexamethasone intravitreal implant 0.7 mg (DEX 0.7) has demonstrated that may improve both central macular thickness (CMT) and best corrected visual acuity (BCVA). Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-1022-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330395PMC
January 2019
7 Reads

Long-term results of glaucoma drainage device surgery.

BMC Ophthalmol 2019 Jan 10;19(1):14. Epub 2019 Jan 10.

Department of Ophthalmology, University Medical Center Schleswig-Holstein, Arnold-Heller Strasse 3, Haus 25, D-24105, Kiel, Germany.

Background: To evaluate long-term results of eyes with glaucoma drainage device (GDD).

Methods: We retrospectively reviewed medical records of all patients who underwent GDD placement at our institution between 2001 and 2014. A total of 110 eyes of 90 patients were studied. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-019-1027-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327392PMC
January 2019
5 Reads

Efficacy of an ocular bandage contact lens for the treatment of dry eye after phacoemulsification.

BMC Ophthalmol 2019 Jan 9;19(1):13. Epub 2019 Jan 9.

Department of Ophthalmology, Research Institute of Surgery & Daping Hospital, Army Medical University, Chongqing, 400042, China.

Background: To evaluate the safety and efficacy of a bandage contact lens for alleviating dry eye discomfort after phacoemulsification.

Methods: In this prospective, controlled study, 60 age-related cataract patients with mild Meibomian gland dysfunction (MGD) were randomized to treatment with an ocular bandage contact lens (BCL) (n = 30) or to an untreated control group (n = 30) after phacoemulsification and intraocular lens implantation. The Ocular Surface Disease Index (OSDI) questionnaire, evaluation of subjective symptoms and evaluation of the best-corrected visual acuity (BCVA) were conducted preoperatively and postoperatively on days 1, 7, 14, 30 and 90. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-1023-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327462PMC
January 2019
8 Reads

Identification of a novel PAX6 mutation in a Chinese family with aniridia.

BMC Ophthalmol 2019 Jan 8;19(1):10. Epub 2019 Jan 8.

Department of Ophthalmology, the Second Affiliated Hospital of Nanchang University, No.1 Minde Road, Donghu District, Nanchang, 330006, China.

Background: This study aims to investigate the clinical characterization and causative genetic defect of a four-generation Chinese family with autosomal dominant aniridia.

Methods: The recruited family members underwent comprehensive routine and ophthalmic examinations, and Sanger sequencing was performed to screen the mutation in PAX6.

Results: A novel heterozygous PAX6 deletion c. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-1009-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325832PMC
January 2019
10 Reads