10,195 results match your criteria Techniques in Ophthalmology [Journal]


Clinicopathologic Correlation of Aneurysmal Type 1 Neovascularization in Age-Related Macular Degeneration.

Ophthalmol Retina 2019 Feb 5;3(2):99-111. Epub 2018 Sep 5.

Vitreous Retina Macula Consultants of New York, New York, New York; LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York; Department of Ophthalmology, New York University School of Medicine, New York, New York. Electronic address:

Purpose: To correlate multimodal retinal imaging with high-resolution epoxy resin histologic analysis aligned to in vivo tomograms in a patient with exudative aneurysmal type 1 (AT1) neovascularization and hemorrhage secondary to age-related macular degeneration (AMD).

Design: Case study and clinicopathologic correlation.

Participant: An 84-year-old man of European descent with AT1 neovascularization secondary to AMD with a 6-year follow-up with combined antiangiogenic and photodynamic therapy. Read More

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http://dx.doi.org/10.1016/j.oret.2018.08.008DOI Listing
February 2019

Variability of Bad Prognosis in Uveal Melanoma.

Ophthalmol Retina 2019 Feb 21;3(2):186-193. Epub 2018 Sep 21.

Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Topic: Survival of patients with uveal melanoma classified to have a bad prognosis.

Clinical Relevance: To explore reasons for reported variability in survival of patients with uveal melanoma classified to have a bad prognosis.

Methods: We searched PUBMED, MEDLINE, and EMBASE for studies reporting survival data for uveal melanoma undergoing prognostic testing with chromosome 3 status by fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH), microsatellite analysis (MSA), multiplex ligation-dependent probe amplification (MLPA), single nucleotide polymorphism (SNP), gene expression profiling (GEP) class, and exon sequencing. Read More

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http://dx.doi.org/10.1016/j.oret.2018.09.007DOI Listing
February 2019

Wide-Field Swept-Source OCT and Angiography in X-Linked Retinoschisis.

Ophthalmol Retina 2019 Feb 19;3(2):178-185. Epub 2018 Sep 19.

University of Iowa Institute for Vision Research, Department of Ophthalmology and Visual Sciences, Carver College of Medicine, Iowa City, Iowa.

Purpose: Retinal vascular and structural changes, particularly outside of the central macula, are not well characterized in X-linked retinoschisis (XLRS). We aim to describe wide-field swept-source OCT (SS-OCT) and swept-source OCT angiography (SS-OCTA) findings in XLRS.

Design: Retrospective, cross-sectional study at a tertiary referral center. Read More

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http://dx.doi.org/10.1016/j.oret.2018.09.006DOI Listing
February 2019

Dengue-Induced Inflammatory, Ischemic Foveolitis and Outer Maculopathy: A Swept-Source Imaging Evaluation.

Ophthalmol Retina 2019 Feb 20;3(2):170-177. Epub 2018 Sep 20.

Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, India.

Purpose: Dengue maculopathy can present with a unique constellation of features resulting in significant central visual morbidity. We aim to describe various findings of dengue-induced inflammatory, ischemic foveolitis, and outer maculopathy (DIII-FOM) and assess the serial changes in vitreous inflammation, retinal structure, and vascularity using swept-source OCT (SS-OCT) and OCT angiography (OCTA).

Design: Retrospective case series. Read More

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http://dx.doi.org/10.1016/j.oret.2018.09.008DOI Listing
February 2019

Choroidal Vasculature from Ultra-Widefield Images without Contrast Dye and Its Application to Vogt-Koyanagi-Harada Disease.

Ophthalmol Retina 2019 Feb 25;3(2):161-169. Epub 2018 Sep 25.

Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; Japan-Clinical Retina Research Team (J-CREST), Kagoshima, Japan. Electronic address:

Purpose: To develop a method to obtain ultra-widefield choroidal vessel images with a fundus camera without using dye, and its application in Vogt-Koyanagi-Harada (VKH) disease.

Design: Experimental study and case series.

Participants: Patients with unilateral retinal disorders and those with VKH disease who had undergone ultra-widefield imaging were studied. Read More

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http://dx.doi.org/10.1016/j.oret.2018.09.005DOI Listing
February 2019

Mineralocorticoid Receptor Antagonists in Central Serous Chorioretinopathy: A Meta-Analysis of Randomized Controlled Trials.

Ophthalmol Retina 2019 Feb 15;3(2):154-160. Epub 2018 Sep 15.

Division of Ophthalmology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

Topic: A meta-analysis comparing mineralocorticoid receptor (MR) antagonists (eplerenone or spironolactone) versus observation or placebo in the treatment of central serous chorioretinopathy (CSCR) based on best-corrected visual acuity (BCVA) and subretinal fluid (SRF) level data from randomized controlled trials (RCTs).

Clinical Relevance: Central serous chorioretinopathy patients may demonstrate decreased visual acuity, reduced contrast sensitivity, scotomas, and metamorphopsia. Although multiple treatment options for CSCR have been proposed, compelling evidence for any particular method is still lacking. Read More

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http://dx.doi.org/10.1016/j.oret.2018.09.003DOI Listing
February 2019

Sensitivity and Specificity of Smartphone-Based Retinal Imaging for Diabetic Retinopathy: A Comparative Study.

Ophthalmol Retina 2019 Feb 28;3(2):146-153. Epub 2018 Sep 28.

Vitreoretinal Services, Aravind Eye Hospitals, and Postgraduate Institute of Ophthalmology, Pondicherry, India.

Purpose: To determine the sensitivity and specificity of a smartphone-based fundus camera, the Remidio Fundus on Phone (FOP; Remidio Innovative Solutions Pvt. Ltd., Bengaluru, India) in detecting diabetic retinopathy (DR) compared with a conventional tabletop fundus camera and clinical examination. Read More

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http://dx.doi.org/10.1016/j.oret.2018.09.016DOI Listing
February 2019

Fungal Endophthalmitis after Intravitreal Injections of Triamcinolone Contaminated by a Compounding Pharmacy: Five-Year Follow-up of 23 Patients.

Ophthalmol Retina 2019 Feb 21;3(2):133-139. Epub 2018 Sep 21.

Macula and Retina Institute, Los Angeles and Glendale, California; Molecular Insight Research Foundation, Los Angeles and Glendale, California.

Purpose: To report the 5-year outcome of an outbreak of Bipolaris hawaiiensis fungal endophthalmitis caused by contamination of intravitreal triamcinolone from Franck's Compounding Pharmacy in Ocala, Florida.

Design: Retrospective case series.

Participants: Twenty-three patients (n = 25 eyes). Read More

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http://dx.doi.org/10.1016/j.oret.2018.09.009DOI Listing
February 2019

En Face Imaging of Geographic Atrophy Using Different Swept-Source OCT Scan Patterns.

Ophthalmol Retina 2019 Feb 14;3(2):122-132. Epub 2018 Sep 14.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:

Purpose: Different swept-source (SS) OCT scan patterns were used to image geographic atrophy (GA) to determine if they provided similar area and enlargement measurements in eyes with age-related macular degeneration (AMD).

Design: Prospective, observational case series.

Participants: Patients with GA secondary to nonexudative AMD. Read More

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http://dx.doi.org/10.1016/j.oret.2018.09.004DOI Listing
February 2019

Changes in Retinal Layer Thickness in the Contralateral Eye of Patients with Unilateral Neovascular Age-Related Macular Degeneration.

Ophthalmol Retina 2019 Feb 27;3(2):112-121. Epub 2018 Sep 27.

Doheny Eye Institute, Los Angeles, California; Department of Ophthalmology, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California. Electronic address:

Purpose: To evaluate the thickness of the outer retinal layers and its relationship with visual function in fellow eyes of participants with unilateral neovascular age-related macular degeneration (AMD).

Design: Longitudinal study.

Participants: We enrolled 105 subjects with unilateral neovascular AMD from 3 clinical centers in Europe. Read More

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http://dx.doi.org/10.1016/j.oret.2018.09.017DOI Listing
February 2019

Asymmetry of Retinopathy of Prematurity Border in the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity Study.

Ophthalmol Retina 2019 Mar 9;3(3):278-284. Epub 2018 Oct 9.

Division of Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Purpose: To measure the location of the retinopathy of prematurity (ROP) border in a sample of premature infants developed ROP and to determine the location for predicting subsequent development of referral-warranted ROP (defined as stage 3 ROP, zone I ROP, or plus disease) or treated ROP.

Design: Secondary analysis of data from an observational cohort study, the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity study.

Participants: Infants with birth weight (BW) of less than 1251 g with at least 1 examination and imaging session at 34 weeks postmenstrual age (PMA) or younger with ROP not meeting referral-warranted ROP and at least 1 subsequent examination at 36 weeks PMA or older. Read More

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http://dx.doi.org/10.1016/j.oret.2018.10.003DOI Listing

Enhanced Depth Imaging OCT of Ultrasonographically Flat Choroidal Nevi Demonstrates 5 Distinct Patterns.

Ophthalmol Retina 2019 Mar 9;3(3):270-277. Epub 2018 Oct 9.

Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

Purpose: To characterize the enhanced depth imaging (EDI) OCT features of ultrasonographically flat choroidal nevi.

Design: Retrospective observational study.

Participants: Patients with ultrasonographically flat choroidal nevi identified over a 3-year period. Read More

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http://dx.doi.org/10.1016/j.oret.2018.10.004DOI Listing

Thomas A. Swift's Electric Rifle Injuries to the Eye and Ocular Adnexa: The Management of Complex Trauma.

Ophthalmol Retina 2019 Mar 10;3(3):258-269. Epub 2018 Oct 10.

Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Electronic address:

Purpose: To report the ocular and adnexal injuries sustained by patients with Thomas A. Swift's electric rifles (TASER; TASER International, Scottsdale, AZ), review the literature, and discuss the management of this complex trauma.

Design: Multicenter, retrospective case series and literature review. Read More

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http://dx.doi.org/10.1016/j.oret.2018.10.005DOI Listing

Intraoperative OCT Features and Postoperative Ellipsoid Mapping in Primary Macula-Involving Retinal Detachments from the PIONEER Study.

Ophthalmol Retina 2019 Mar 18;3(3):252-257. Epub 2018 Oct 18.

The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Purpose: Intraoperative OCT (iOCT) has enabled visualization of subtle structural details during surgical interventions, including retinal detachment repair. The purpose of this study was to evaluate iOCT findings during retinal detachment repair and to assess their impact on anatomic and functional outcomes, including outer retinal integrity.

Design: The PIONEER Intraoperative and Perioperative OCT Study is a prospective cohort, institutional review board-approved study. Read More

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http://dx.doi.org/10.1016/j.oret.2018.10.006DOI Listing

Comparison of a Three-Dimensional Heads-Up Display Surgical Platform with a Standard Operating Microscope for Macular Surgery.

Ophthalmol Retina 2019 Mar 7;3(3):244-251. Epub 2018 Nov 7.

Mid Atlantic Retina, the Retina Service of Wills Eye Hospital, Philadelphia, Pennsylvania. Electronic address:

Purpose: To assess safety, efficacy, and outcomes of vitreoretinal surgery for macular pathology using a 3-dimensional heads-up display (3D HUD) surgical platform compared with a standard operating microscope (SOM).

Design: Prospective, single-center, unmasked, randomized study.

Participants: Patients undergoing pars plana vitrectomy (PPV) for epiretinal membrane (ERM) or full-thickness macular hole (MH) at Wills Eye Hospital. Read More

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http://dx.doi.org/10.1016/j.oret.2018.10.016DOI Listing

Sex-Related Differences in the Progression of Posterior Vitreous Detachment with Age.

Ophthalmol Retina 2019 Mar 9;3(3):237-243. Epub 2018 Nov 9.

Hayashi Eye Hospital, Fukuoka, Japan.

Purpose: To compare the difference in the progression of posterior vitreous detachment (PVD) between men and women in relation to age.

Design: Observational cross-sectional study.

Participants: One hundred eyes of 100 male patients and 100 eyes of 100 female patients in 4 age groups: 40 to 49 years of age, 50 to 59 years of age, 60 to 69 years of age, and 70 years of age or older. Read More

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http://dx.doi.org/10.1016/j.oret.2018.10.017DOI Listing

Loss to Follow-up After Intravitreal Anti-Vascular Endothelial Growth Factor Injections in Patients with Diabetic Macular Edema.

Ophthalmol Retina 2019 Mar 10;3(3):230-236. Epub 2018 Nov 10.

Retina Service, Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

Purpose: To determine the rate of loss to follow-up (LTFU) and associated risk factors in patients with nonproliferative diabetic retinopathy (NPDR) who had diabetic macular edema (DME) and were receiving intravitreal anti-vascular endothelial growth factor (VEGF) injections.

Design: Retrospective cohort study.

Participants: A total of 2595 NPDR patients with DME who received at least one anti-VEGF injection at a single large retina practice from January 1, 2012, to January 1, 2017. Read More

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http://dx.doi.org/10.1016/j.oret.2018.11.002DOI Listing

A Multicountry Comparison of Real-World Management and Outcomes of Polypoidal Choroidal Vasculopathy: Fight Retinal Blindness! Cohort.

Ophthalmol Retina 2019 Mar 15;3(3):220-229. Epub 2018 Nov 15.

Department of Ophthalmology, University of Auckland, Auckland, New Zealand.

Purpose: To compare the 12-month real-world visual and disease activity outcomes of eyes with polypoidal choroidal vasculopathy (PCV) treated with a combination of photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) injections (combination group) versus those eyes treated with anti-VEGF monotherapy alone with rescue PDT being used as required (monotherapy group).

Design: Database comparative observational study.

Participants: Eyes with PCV as graded in the Fight Retinal Blindness! database from Australia, New Zealand, Singapore, and Switzerland. Read More

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http://dx.doi.org/10.1016/j.oret.2018.11.003DOI Listing

Predictive Value of the OCT Double-Layer Sign for Identifying Subclinical Neovascularization in Age-Related Macular Degeneration.

Ophthalmol Retina 2019 Mar 30;3(3):211-219. Epub 2018 Oct 30.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:

Purpose: Structural OCT images from eyes with nonexudative age-related macular degeneration (AMD) were graded for the presence of a double-layer sign to determine if the double-layer sign predicted subclinical macular neovascularization (MNV).

Design: Prospective, observational study.

Participants: Nonexudative AMD patients with and without subclinical MNV identified by swept-source (SS) OCT angiography (OCTA). Read More

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http://dx.doi.org/10.1016/j.oret.2018.10.012DOI Listing

Determinants of Reading Performance in Eyes with Foveal-Sparing Geographic Atrophy.

Ophthalmol Retina 2019 Mar 22;3(3):201-210. Epub 2018 Nov 22.

Department of Ophthalmology, University of Bonn, Bonn, Germany. Electronic address:

Purpose: To identify anatomic determinants of reading performance in eyes with foveal-sparing geographic atrophy (GA).

Design: Prospectively recruited, cross-sectional study, SIGHT (clinicaltrials.gov identifier, NCT02332343). Read More

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http://dx.doi.org/10.1016/j.oret.2018.11.005DOI Listing

Reflectance and Thickness Analysis of Retinal Layers in Patients with Epiretinal Membranes Using Spectral-Domain OCT before and after Vitrectomy with Membrane Peeling.

Ophthalmol Retina 2019 Apr 24;3(4):371-378. Epub 2018 Nov 24.

Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida. Electronic address:

Purpose: To compare thickness and reflectance of retinal layer findings in patients with idiopathic epiretinal membranes (ERMs) before and after surgery with those of normal controls.

Design: Retrospective study.

Participants: Patients with ERMs before and after surgery and healthy controls. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24686530183045
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http://dx.doi.org/10.1016/j.oret.2018.11.009DOI Listing
April 2019
1 Read

Yearly Treatment Patterns for Patients with Recently Diagnosed Diabetic Macular Edema.

Ophthalmol Retina 2019 Apr 7;3(4):362-370. Epub 2018 Dec 7.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri.

Purpose: To describe the treatment patterns and the predictors of different treatment standards in recently diagnosed diabetic macular edema (DME) patients in a nationally representative sample.

Design: A retrospective cohort study using administrative claims data from January 1, 2007, through March 31, 2015. Patients were grouped into yearly cohorts. Read More

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http://dx.doi.org/10.1016/j.oret.2018.11.014DOI Listing

Longitudinal Wide-Field Swept-Source OCT Angiography of Neovascularization in Proliferative Diabetic Retinopathy after Panretinal Photocoagulation.

Ophthalmol Retina 2019 Apr 24;3(4):350-361. Epub 2018 Nov 24.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:

Purpose: Wide-field swept-source (SS) OCT angiography (OCTA) was compared with ultrawide-field (UWF) fluorescein angiography (FA) for evaluating neovascularization (NV) before and after panretinal photocoagulation (PRP) in eyes with treatment-naive proliferative diabetic retinopathy (PDR).

Design: Prospective, observational, consecutive case series.

Participants: Patients with treatment-naive PDR. Read More

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http://dx.doi.org/10.1016/j.oret.2018.11.008DOI Listing

Accuracy of Detection and Grading of Diabetic Retinopathy and Diabetic Macular Edema Using Teleretinal Screening.

Ophthalmol Retina 2019 Apr 24;3(4):343-349. Epub 2018 Dec 24.

Baylor College of Medicine, Department of Ophthalmology, Houston, Texas; Ben Taub General Hospital, Department of Ophthalmology, Harris Health System, Houston, Texas. Electronic address:

Purpose: To determine the accuracy of a county teleretinal screening program of detecting referable diabetic retinopathy (DR) and treatable diabetic macular edema (DME), as well as to evaluate patient compliance with clinic follow-up after referral from teleretinal screening.

Design: Retrospective observational study.

Participants: Patients in the Harris Health System (HHS, Houston, TX) older than 18 years of age who underwent teleretinal screening between July 2014 and July 2016. Read More

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http://dx.doi.org/10.1016/j.oret.2018.12.003DOI Listing

Driving and Visual Acuity in Patients with Age-Related Macular Degeneration.

Ophthalmol Retina 2019 Apr 17;3(4):336-342. Epub 2018 Nov 17.

Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado.

Purpose: To assess driving status, habitual visual acuity (VA) in the better-seeing eye, and self-reported driving difficulty among patients diagnosed with age-related macular degeneration (AMD).

Design: Cross-sectional cohort study of 553 AMD patients' habitual VA, self-reported driving status, and driving difficulty at time of interview.

Participants: Patients diagnosed with AMD and recruited into the University of Colorado registry. Read More

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http://dx.doi.org/10.1016/j.oret.2018.11.004DOI Listing

Imaging Characteristics of Choroidal Neovascular Lesions in the AREDS2-HOME Study: Report Number 4.

Ophthalmol Retina 2019 Apr 11;3(4):326-335. Epub 2019 Jan 11.

National Eye Institute, Bethesda, Maryland.

Purpose: To characterize choroidal neovascular (CNV) lesions and the corresponding change in visual acuity (VA) in eyes that converted to neovascular age-related macular degeneration (AMD) in the Age-Related Eye Disease Study 2-HOme Monitoring of the Eye Study. (AREDS2-HOME Study).

Design: Cohort study. Read More

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http://dx.doi.org/10.1016/j.oret.2019.01.004DOI Listing

Distribution of OCT Features within Areas of Macular Atrophy or Scar after 2 Years of Anti-VEGF Treatment for Neovascular AMD in CATT.

Ophthalmol Retina 2019 Apr 3;3(4):316-325. Epub 2018 Dec 3.

Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania.

Purpose: Macular atrophy and scar increase in prevalence during treatment for neovascular age-related macular degeneration and are associated with poor visual acuity. We sought to identify the distribution of spectral-domain OCT (SD-OCT)-determined features and subretinal lesion thicknesses at sites of macular scar or atrophy after 2 years of treatment in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).

Design: Cross-sectional analysis. Read More

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http://dx.doi.org/10.1016/j.oret.2018.11.011DOI Listing

Fellow Eye Status Is a Biomarker for the Progression Rate of Geographic Atrophy: A Systematic Review and Meta-analysis.

Ophthalmol Retina 2019 Apr 7;3(4):305-315. Epub 2018 Dec 7.

Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

Topic: Systematic review and meta-analysis of how fellow eye status predicts the progression rate of geographic atrophy (GA).

Clinical Relevance: The status of age-related macular degeneration (AMD) in the fellow eye has been used as an indicator of the GA progression rates in primary eyes, but the reported growth rates vary widely in prior clinical studies.

Methods: We searched MEDLINE, EMBASE, Cochrane Library, Clinicaltrials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24686530183042
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http://dx.doi.org/10.1016/j.oret.2018.11.013DOI Listing
April 2019
1 Read

Deep Learning-Based Algorithms in Screening of Diabetic Retinopathy: A Systematic Review of Diagnostic Performance.

Ophthalmol Retina 2019 Apr 3;3(4):294-304. Epub 2018 Nov 3.

Department of Ophthalmology, Odense University Hospital, Odense, Denmark; Research Unit of Ophthalmology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; Steno Diabetes Center Odense, Odense, Denmark. Electronic address:

Topic: Diagnostic performance of deep learning-based algorithms in screening patients with diabetes for diabetic retinopathy (DR). The algorithms were compared with the current gold standard of classification by human specialists.

Clinical Relevance: Because DR is a common cause of visual impairment, screening is indicated to avoid irreversible vision loss. Read More

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http://dx.doi.org/10.1016/j.oret.2018.10.014DOI Listing

LASIK-induced corneal changes after correction of hyperopia with and without application of Mitomycin-C.

BMC Ophthalmol 2019 Apr 23;19(1):93. Epub 2019 Apr 23.

Department of ophthalmology, Faculty of Medicine Suez Canal University, Ismailia, Egypt.

Background: The study aimed to assess the role of intraoperative mitomycin-C (MMC) application during hyperopic LASIK correction (+ 1.00 D to + 6.00 D) by examining topographic corneal changes and incidence of regression over a one-year follow-up period. Read More

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http://dx.doi.org/10.1186/s12886-019-1100-7DOI Listing

Cytokine profiling reveals increased serum inflammatory cytokines in idiopathic choroidal neovascularization.

BMC Ophthalmol 2019 Apr 24;19(1):94. Epub 2019 Apr 24.

Eye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: The exact pathogenesis of idiopathic choroidal neovascularization (ICNV) remains unclear. Cytokine-mediated inflammation has been thought to be involved in the pathophysiology of ICNV. The purpose of this study was to investigate serum cytokine profiles in patients with ICNV and to explore the relationship between serum cytokine levels and ICNV severity. Read More

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http://dx.doi.org/10.1186/s12886-019-1101-6DOI Listing

Intravitreal dexamethasone implant for central retinal vein occlusion without macular edema.

BMC Ophthalmol 2019 Apr 17;19(1):92. Epub 2019 Apr 17.

Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211, Eonjuro, Gangnam-gu, Seoul, 06273, South Korea.

Background: To evaluate the efficacy of an intravitreal dexamethasone (IVD) implant (Ozurdex®) for the treatment of central retinal vein occlusion (CRVO) without macular edema (ME).

Methods: A retrospective cohort study was designed, and 20 eyes of 20 patients diagnosed with non-ischemic CRVO without ME were included. A total of 10 CRVO eyes were observed without treatment, and another 10 CRVO eyes received a single IVD injection at baseline. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-019-1097-yDOI Listing
April 2019
2 Reads

Incidence of retinopathy of prematurity type 1 and type 2 in a regional Hospital of Social Security in the state of Queretaro, Mexico (2017-2018).

BMC Ophthalmol 2019 Apr 15;19(1):91. Epub 2019 Apr 15.

Instituto Mexicano de Oftalmología IAP, Circuito de Estadio de Corregidora, sin número, Santiago de Querétaro, Querétaro, Mexico.

Background: Retinopathy of prematurity (ROP), the primary cause of blindness in children, is a potential complication for 7.7% of live births in Mexico. Given that less than one-third of all neonatal intensive care units follow Mexican National ROP guidelines, there have been few reports regarding the incidences of types 1 and 2 ROP. Read More

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http://dx.doi.org/10.1186/s12886-019-1095-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466710PMC

Clinical predictors at diagnosis of low risk histopathology in unilateral advanced retinoblastoma.

Ophthalmology 2019 Apr 12. Epub 2019 Apr 12.

Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Canada; Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. Electronic address:

Objective: Attempted eye salvage for unilateral (cT2b/Group D) retinoblastoma may increase risk of tumor spread compared to primary enucleation. Identification of clinical features predictive of low histopathologic risk would support safe trial salvage.

Design: Retrospective, non-comparative single-institutional observational case series PARTICIPANTS: Children with unilateral cT2b/Group D retinoblastoma (January 2008-February 2018) managed with primary enucleation at the Hospital for Sick Children (SickKids), Toronto, Canada. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.04.003DOI Listing

The Relative Impact of Patient, Physician, and Geographic Factors on Variation in Primary Rhegmatogenous Retinal Detachment Management.

Ophthalmology 2019 Apr 12. Epub 2019 Apr 12.

University of California San Francisco Department of Ophthalmology, San Francisco, CA, United States.

Objective: To evaluate geographic variation and characterize the relative contributions of patient characteristics, physician practice, and geographic region on variation in primary rhegmatogenous retinal detachment (RRD) management.

Design: Retrospective claims-based analysis PARTICIPANTS: 12,779 commercially-insured patients with incident RRD diagnosed between 2008 and 2016.

Methods: We determined whether patients underwent primary RRD repair within 60 days of diagnosis, and identified type of repair performed. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.04.019DOI Listing

Simulation training in vitreoretinal surgery: a systematic review.

BMC Ophthalmol 2019 Apr 11;19(1):90. Epub 2019 Apr 11.

Department of Ophthalmology, Odense University Hospital, J.B. Winsløws Vej 4, DK-5000, Odense C, Denmark.

Background: The purpose of this study was to perform a systematic review of the current literature on simulator-based training in vitreoretinal surgery (VRS). We examined the results regarding simulated VRS and provided an overview of how the current results may be employed in VRS training. Lastly, we evaluated the quality of these results. Read More

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http://dx.doi.org/10.1186/s12886-019-1098-xDOI Listing

Visual Acuity Outcomes after Cataract Surgery: High- vs. low-volume surgeons.

Ophthalmology 2019 Apr 8. Epub 2019 Apr 8.

Aravind Eye Hospital, Madurai, Tamil Nadu, India.

Objective: Primary objective was to assess associations between annual surgeon case volume and visual acuity outcomes following cataract surgery. Secondary objectives included (i) assessing for associations between other case and patient characteristics and post-operative visual acuity outcomes and (ii) assessing for associations between annual surgeon case volume and complication rates.

Design: Database study. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.03.033DOI Listing

A Phase 3, Randomized, Double-Masked Study of OTX-101 Ophthalmic Solution 0.09% in the Treatment of Dry Eye Disease.

Ophthalmology 2019 Apr 6. Epub 2019 Apr 6.

Virginia Eye Consultants and Eastern Virginia Medical School, Norfolk, VA, USA.

Objective: Evaluate the safety and efficacy of OTX-101, a novel aqueous nanomicellar formulation of cyclosporine (0.09%), in the treatment of subjects with dry eye disease (DED).

Design: A randomized, multicenter, vehicle-controlled, double-masked, phase 3 clinical trial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420183132
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http://dx.doi.org/10.1016/j.ophtha.2019.03.050DOI Listing
April 2019
6 Reads

Visual and optical quality outcomes of SMILE and FS-LASIK for myopia in the very early phase after surgery.

BMC Ophthalmol 2019 Apr 8;19(1):88. Epub 2019 Apr 8.

Department of Ophthalmology, Daping Hospital of Army Medical University of PLA, No. 10 Changjiangzhi Road, Yuzhong District, Chongqing, 400042, China.

Background: Small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK) are frequently used to treat myopia. However, little is known about the impact on recovery of these approaches in the very early postsurgical phase (within 24 h).

Methods: To compare the efficacy of these two procedures for the treatment of myopia in the early phase after surgery, differences in visual acuity, OSI (objective scattering index), cutoff for modulation transfer function (MTF), and SR (Strehl ratio) between SMILE and FS-LASIK were evaluated at 0, 2, 4 and 24 h postoperatively using two-way analysis of variance (ANOVA). Read More

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http://dx.doi.org/10.1186/s12886-019-1096-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454732PMC

Diagnostic test accuracy of diabetic retinopathy screening by physician graders using a hand-held non-mydriatic retinal camera at a tertiary level medical clinic.

BMC Ophthalmol 2019 Apr 8;19(1):89. Epub 2019 Apr 8.

Public Health for Eye Care and Disability, International Centre for Eye Health, Clinical Research Department, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Background: The evidence on diagnostic test accuracy (DTA) of diabetic retinopathy (DR) screening utilising photographic studies by non-ophthalmologist personnel in low and middle-income country (LMIC) settings is scarce. We aimed to assess DTA of DR screening using a nonmydriatic hand-held digital camera by trained general physicians in a non-ophthalmic setting.

Methods: This study is a validation of a screening intervention. Read More

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http://dx.doi.org/10.1186/s12886-019-1092-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454614PMC
April 2019
1 Read

Comparison of clinical features and visual outcome between Sympathetic ophthalmia and Vogt-Koyanagi-Harada disease in Chinese Patients.

Ophthalmology 2019 Apr 5. Epub 2019 Apr 5.

Purpose: To characterize the clinical features of Sympathetic ophthalmia (SO) and make a comparison between SO and Vogt-Koyanagi-Harada (VKH) disease in Chinese patients.

Design: Retrospective case series.

Participants: A total of 131 consecutive SO and 500 VKH patients randomly selected out of those referred to our uveitis center from April 2008 to June 2018. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.03.049DOI Listing

Neurodevelopmental Outcomes Following Intravitreal Bevacizumab Therapy for Retinopathy of Prematurity: a prospective, case-control study.

Ophthalmology 2019 Apr 4. Epub 2019 Apr 4.

Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Objective: To evaluate the neurodevelopmental and ocular developmental outcomes in premature children who have undergone intravitreal bevacizumab injection (IVB) for treatment of type 1 retinopathy of prematurity (ROP) DESIGN: Prospective case-control study SUBJECTS: We enrolled 3 groups of premature patients: premature children who had no history of ROP (Group 0), premature children with history of ROP without treatment (Group 1), and premature children who had received a single IVB (0.625 mg) for treatment of ROP (Group 2).

Methods: Ocular developmental assessment, including cycloplegic refractometry, axial length and Cardiff acuity, and neurodevelopmental assessment via the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III), were performed at the age of 1 to 3 years, and were compared between groups. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.03.048DOI Listing
April 2019
1 Read

Unbiased Pathogen Detection and Host Gene Profiling for Conjunctivitis.

Ophthalmology 2019 Apr 3. Epub 2019 Apr 3.

Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA, USA; Department of Ophthalmology, University of California, San Francisco, CA, USA. Electronic address:

Purpose: The etiology of conjunctivitis is often misdiagnosed. An ideal diagnostic test would identify all possible infectious causes. In this study, we apply unbiased metagenomic RNA deep sequencing (MDS) to identify pathogens causing conjunctivitis. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.03.039DOI Listing
April 2019
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Swept-Source Optical Coherence Tomography for Evaluating the Lamina Cribrosa A Report by the American Academy of Ophthalmology.

Ophthalmology 2019 Apr 3. Epub 2019 Apr 3.

Harvard Medical School, Department of Ophthalmology, Massachusetts Eye & Ear, Glaucoma Service, Boston, Massachusetts.

Objective: To review the published literature on the use of swept-source optical coherence tomography (SS-OCT) for evaluating the lamina cribrosa in glaucoma.

Methods: A PubMed and Cochrane Library literature search initially conducted on March 3, 2017 and updated on June 26, 2018 yielded a total of 64 articles. Articles that were reviews or that were not published in English were excluded, and 29 were found to fit the inclusion criteria. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.03.044DOI Listing
April 2019
1 Read

Monocanalicular Stents in Eyelid Lacerations A Report by the American Academy of Ophthalmology.

Ophthalmology 2019 Apr 3. Epub 2019 Apr 3.

Vanderbilt Eye Institute, Vanderbilt University, Nashville, Tennessee.

Purpose: To determine the efficacy and complication rates of monocanalicular stents in the setting of canalicular lacerations.

Methods: A literature search was performed in May 2018 in the PubMed database to identify all English-language reports of monocanalicular stenting to address canalicular lacerations. Studies that did not include at least 10 patients with at least 3 months of follow-up evaluation after surgery were excluded. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.03.045DOI Listing
April 2019
2 Reads

The Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration: Results from the Randomized Phase 2 Ladder Clinical Trial.

Ophthalmology 2019 Apr 1. Epub 2019 Apr 1.

Genentech, Inc., South San Francisco, California.

Purpose: To evaluate the safety and efficacy of the Port Delivery System with ranibizumab (PDS) for neovascular age-related macular degeneration (nAMD) treatment.

Design: Phase 2, multicenter, randomized, active treatment-controlled clinical trial.

Participants: Patients diagnosed with nAMD within 9 months who had received ≥ 2 prior anti-vascular endothelial growth factor intravitreal injections and were responsive to treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420183332
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http://dx.doi.org/10.1016/j.ophtha.2019.03.036DOI Listing
April 2019
13 Reads

Longitudinal Retinal Perfusion Status in Eyes with Diabetic Macular Edema Receiving Intravitreal Aflibercept or Laser in VISTA study.

Ophthalmology 2019 Apr 1. Epub 2019 Apr 1.

Regeneron Pharmaceuticals, Inc., Tarrytown, New York, United States.

Purpose: To evaluate changes in retinal perfusion status with intravitreal aflibercept injection (IAI) and laser treatment in the phase 3 VISTA study of patients with diabetic macular edema (DME).

Design: Post-hoc analysis of a double-masked, randomized, active-controlled, phase 3 trial.

Participants: Patients with center-involved DME in the study eye. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.03.040DOI Listing
April 2019
1 Read

Adjunctive dexamethasone implant in patients with atopic dermatitis and retinal detachment undergoing vitrectomy and silicone oil tamponade: an interventional case series.

BMC Ophthalmol 2019 Apr 3;19(1):86. Epub 2019 Apr 3.

Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, 88, Olympic-ro 43-Gil, Songpa-gu, Seoul, 05505, Korea.

Background: To report the clinical course and outcomes of adjunctive dexamethasone implants in patients with atopic dermatitis (AD) and retinal detachment (RD) undergoing vitrectomy and silicone oil tamponade.

Methods: This retrospective, interventional case series included AD patients with RD and various degrees of proliferative vitreoretinopathy (PVR) who were scheduled to undergo vitrectomy. Following total vitrectomy and retinopexy, silicone oil tamponade was performed. Read More

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http://dx.doi.org/10.1186/s12886-019-1094-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448232PMC
April 2019
2 Reads
1.075 Impact Factor

Epidemiology and clinical features of viral anterior uveitis in southern Taiwan-diagnosis with polymerase chain reaction.

BMC Ophthalmol 2019 Apr 3;19(1):87. Epub 2019 Apr 3.

Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist, Kaohsiung, 833, Taiwan.

Background: To report the epidemiology and clinical features of viral anterior uveitis in patients in southern Taiwan.

Methods: A retrospective, case series study. HLA-B27 negative anterior uveitis patients with increased intraocular pressure or corneal edema seen at Kaohsiung Chang Gung Memorial Hospital from January 1, 2007 to January 31, 2018 had their aqueous sent for polymerase chain reaction analysis. Read More

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http://dx.doi.org/10.1186/s12886-019-1093-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448235PMC
April 2019
2 Reads

Individualized penetrating keratoplasty using edge-trimmed glycerol-preserved donor corneas for perforated corneal ulcers.

BMC Ophthalmol 2019 Apr 2;19(1):85. Epub 2019 Apr 2.

Department of Ophthalmology, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai, 200065, China.

Purpose: To report a surgical technique and the surgical outcomes of individualized penetrating keratoplasty (PK) using edge-trimmed glycerol-preserved donor corneas for perforated corneal ulcers.

Methods: Fourteen perforated eyes from 14 patients who underwent individualized PK using edge-trimmed glycerol-preserved donor corneas, were included in the retrospective study. The perforations were mainly 1-2 mm in size except for one that was 2. Read More

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http://dx.doi.org/10.1186/s12886-019-1091-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444435PMC
April 2019
1 Read