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Acta Reumatol Port 2018 Jul-Sep;43(3):235-236

Hospital de Santa Maria.

A 24-day-old female newborn presented with multiple annular erythematous plaques with a targetoid shape, on the forehead, neck and upper trunk, that had begun ten days earlier. She had been diagnosed with citrullinemia type 1 in the first week of life and arginine supplementation was initiated. Her personal and family history was otherwise unremarkable. Read More

G Ital Dermatol Venereol 2018 Oct;153(5):685-691

Unit of Dermatology and Sexually-Trasmitted Diseases, P. Giaccone University Hospital, University of Palermo, Palermo, Italy.

Targetoid hemosiderotic hemangioma represents an uncommon, distinctive, benign lympho-vascular lesion, with a variable clinical appearance, typically occurs in the lower limbs and trunk. Most patients are in their 20's or 30's. We describe three dermoscopic cases followed by the review of the literature. Read More

Br J Dermatol 2018 Sep;179(3):e132

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

Indian J Dermatol 2018 Sep-Oct;63(5):418-423

Department of Dermatology, Dr. D. Y. Patil Medical College and Hospital, DPU, Pune, Maharashtra, India.

Rowell's syndrome (RS) is recognized since 1963 as a presentation of lupus erythematosus (LE) with erythema multiforme-like lesions and characteristic immunological changes. Antiphospholipid syndrome (APS) encompasses antibodies to phospholipids/phospholipid-binding cofactor proteins and/or circulating lupus anticoagulant with clinical manifestations of thrombosis such as recurrent spontaneous abortions, etc. A 32-year-old female with primary infertility since marriage (7 years) and sequential appearance, for the past 6 months, of various lupus-specific cutaneous lesions, "targetoid" lesions on palms, musculoskeletal, ocular and auditory (sensorineural hearing loss [SNHL]) complaints with positive serological profile for SMD-1, SS-A/Ro, SS-B/La, U1-snRNP, Ku, antiphospholipid and anticardiolipin antibodies, and histopathologically confirmed LE is presented as a case of concurrent overlap syndrome, RS and APS, primary infertility, and SNHL. Read More

Hepatology 2018 Dec 12;68(6):2254-2266. Epub 2018 Nov 12.

Department of Mathematics, Ajou University, Suwon, Republic of Korea.

We intraindividually compared the efficacy of magnetic resonance imaging (MRI) with extracellular contrast agents (ECA-MRI) and MRI with hepatobiliary agents (HBA-MRI) for the diagnosis of hepatocellular carcinoma (HCC) using the Liver Imaging Reporting and Data System (LI-RADS). Between November 2016 and November 2017, we enrolled 91 patients with chronic liver disease who underwent both ECA-MRI and HBA-MRI within a 1-month interval for a first detected hepatic nodule on ultrasound. In total, 117 observations (95 HCCs, 19 benign lesions, and 3 other malignancies; median size, 18 mm) were identified with surgical resection. Read More

Pediatr Dermatol 2018 Sep 26;35(5):e294-e297. Epub 2018 Jun 26.

Department of Pathology, New York Presbyterian/Weill Cornell Medical College, New York, NY, USA.

The cutaneous manifestations of Crohn's disease are myriad. A 15-year-old girl presented with recurrent lip swelling and eventual development of diarrhea and targetoid macules on the palms, feet, and back. She was finally diagnosed with Crohn's disease in the setting of a clinical presentation and histopathology consistent with orofacial granulomatosis and erythema multiforme. Read More

Dermatol Res Pract 2018 7;2018:3061084. Epub 2018 May 7.

Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.

Aim: To determine the probable causative factors, clinical features, and treatment outcomes of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS-TEN overlap in children.

Methods: A 20-year database review of all children diagnosed with SJS/TEN/SJS-TEN overlap at the King Chulalongkorn Memorial Hospital, Thailand.

Results: 36 patients (M : F, 16 : 20) with the mean age of 9. Read More

Microsc Res Tech 2018 Apr 20. Epub 2018 Apr 20.

Department of Dermatology, Korea University College of Medicine, Seoul, Korea.

Skin biopsy for AK diagnosis is usually performed on only a limited part of the whole lesion. Therefore, a clinical diagnosis is important. According to a study, there is no significant correlation between histopathological and clinical classification system. Read More

BMJ Case Rep 2018 Apr 17;2018. Epub 2018 Apr 17.

Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

We present an extremely rare case of a 53-year-old woman with an intraoral superficial haemosiderotic lymphovascular malformation (SHLM), also known as hobnail haemangioma. SHLM is a rare, benign, vascular tumour first described as targetoid haemosiderotic haemangioma, with only a handful of cases reported to present in the oral cavity. The diagnosis was established following complete surgical excision of the lesion, and after 14 months, there are still no signs of recurrence. Read More

Int J Dermatol 2018 Aug 11;57(8):913-914. Epub 2018 Apr 11.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.

Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.

David Geffen School of Medicine at UCLA, Los Angeles, California.

Mycoplasma pneumoniae-induced rash and mucositis (MIRM) is a disease characterized by mucosal involvement with variable cutaneous manifestations induced by M. pneumoniae infection. Previously reported rash morphologies include vesiculobullous, targetoid, papular, macular, and morbilliform lesions. Read More

Dermatol Online J 2018 02 15;24(2). Epub 2018 Feb 15.

Feinberg School of Medicine, Northwestern University, Chicago, Illinois,.

Paraneoplastic pemphigus is a severe autoimmune blistering disease presenting in the setting of underlying malignancy. Paraneoplastic pemphigus is associated with diffuse painful stomatitis throughout the oral cavity with extension to the lips. The cutaneous findings are varied and have been described as lichenoid, pemphigoid, and targetoid lesions. Read More

Skinmed 2018 1;16(1):51-53. Epub 2018 Feb 1.

Medical Dermatology Specialists, Phoenix, AZ;

A 23-year-old man presented with new-onset pruritic and painful urticarial lesions and targetoid erythematous plaques on both palms, the trunk, and the upper and lower extremities (Figure 1). Additionally, small pustules were discovered on the neck (Figure 2), and there with edematous erythematous vermillion lips with splaying onto the cutaneous lips without ulceration. The patient stated he had had a fever before the eruption, fatigue, chills, myalgias, and sore throat. Read More

Dermatol Online J 2017 Oct 15;23(10). Epub 2017 Oct 15.

University of Texas Medical Branch at Galveston Department of Dermatology Galveston, Texas.

A 49-year old woman was hospitalized for generalized rash and pruritus following the administration of ophthalmic drops containing ciprofloxacin to treat conjunctivitis. Physical examination demonstrated diffuse erythematous papules and plaques with a targetoid appearance, injected sclera, and multiple erosions in the oropharynx. Skin biopsy confirmed a diagnosis of erythema multiforme major. Read More

J Cutan Med Surg 2018 Jul/Aug;22(4):427-430. Epub 2018 Feb 20.

3 Division of Paediatric Medicine, Section of Dermatology, Hospital for Sick Children, Toronto, ON, Canada.

Background: Erythema multiforme (EM) is a mucocutaneous disease most often associated with preceding herpes simplex virus or Mycoplasma pneumoniae infection. It is characterized by targetoid lesions occurring on the limbs and head and neck. Mucosal involvement can be extensive. Read More

Dermatopathology (Basel) 2017 Jan-Dec;4(1-4):13-17. Epub 2017 Nov 16.

Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Background/aims: The development of programmed cell death-1 (PD-1) inhibitors has greatly improved patient outcomes in the treatment of a variety of advanced malignancies. These novel immunotherapies are not without adverse effects, the most common of which are dermatologic.

Methods: We report our experience with an atypical erythema multiforme-like eruption in a patient with primary central nervous system diffuse large B-cell lymphoma treated with nivolumab. Read More

Am Fam Physician 2017 Dec;96(11):739-741

Walter Reed National Military Medical Center, Bethesda, MD, USA.

Clin Rev Allergy Immunol 2018 Feb;54(1):177-184

Unité d'allergologie, Service d'immunologie et d'allergologie, Hôpitaux Universitaires de Genève HUG, Rue Micheli-du-Crest 24, CH-1211, Genève, Switzerland.

Recognition and timely adequate treatment of erythema multiforme remain a major challenge. In this review, current diagnostic guidelines, potential pitfalls, and modern/novel treatment options are summarized with the aim to help clinicians with diagnostic and therapeutic decision-making. The diagnosis of erythema multiforme, that has an acute, self-limiting course, is based on its typical clinical picture of targetoid erythematous lesions with predominant acral localization as well as histological findings. Read More

Cureus 2017 Nov 10;9(11):e1836. Epub 2017 Nov 10.

Department of Dermatology, Brigham & Women's Hospital, Harvard Medical School.

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is a cutaneous drug reaction characterized by erythema over the buttocks, thighs, groin, and flexural regions most commonly associated with the use of beta-lactam antibiotics. Although the exact pathophysiology of this disease remains unknown, it is theorized to be the result of a delayed hypersensitivity response presenting as a cutaneous eruption days to weeks after exposure to the drug. The treatment involves discontinuation of the suspected medication, symptomatic control of pruritus, and topical steroid therapy. Read More

J Eur Acad Dermatol Venereol 2018 Jun 24;32(6):879-888. Epub 2018 Jan 24.

First Department of Dermatology, Aristotle University, Thessaloniki, Greece.

Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumours, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically 'false-positive' and 'false-negative' tumours do exist. False-positive diagnosis usually leads to unnecessary excisions. Read More

J Cutan Pathol 2018 Apr 9;45(4):274-277. Epub 2018 Feb 9.

Departments of Dermatology and Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Lyme disease classically evolves through clinical manifestations according to the stage of illness. Because many of the systemic symptoms are non-specific, and because serology may yield false negative results, cutaneous findings merit even greater importance to diagnosis. The prototypical skin lesion, erythema migrans (EM), occurs early and is the only independent diagnostic clinical feature according to the guidelines of the Infectious Diseases Society of America. Read More

Pediatr Dermatol 2018 Jan 28;35(1):e45-e48. Epub 2017 Dec 28.

Department of Dermatology, Columbia University Medical Center, New York, NY, USA.

A 2-year-old boy with influenza B infection and rapidly worsening targetoid skin lesions with mucosal involvement was diagnosed with Stevens-Johnson syndrome (SJS) and treated with oseltamivir and intravenous immunoglobulin, with resolution of illness. Subsequent quadrivalent inactivated influenza vaccine was well tolerated. This case highlights the rarity of SJS in the setting of influenza B infection and addresses the safety of administering subsequent influenza vaccines to such individuals. Read More

J Gen Intern Med 2018 Apr 22;33(4):570-572. Epub 2017 Dec 22.

Harvard Medical School, Boston, MA, USA.

We report the case of a 51-year-old woman presenting with a targetoid rash and pancytopenia after a tick bite. Initial evaluation was notable for severe neutropenia on the complete blood cell count differential, a positive Lyme IgM antibody, and a peripheral blood smear demonstrating atypical lymphocytes. While her pancytopenia was initially attributed to tick-borne illness, peripheral flow cytometry showed 7% myeloblasts, and a bone marrow biopsy confirmed 60% blasts. Read More

An Bras Dermatol 2017 ;92(5 Suppl 1):30-33

Private practice - Tubarão (SC), Brazil.

Blue nevus is a benign melanocytic lesion, typically asymptomatic and of unknown etiology. Many histological subtypes are recognized, the most commons being: common blue nevus, cellular blue nevus, and combined blue nevus. New rare variants have been described in the literature, with emphasis on eruptive blue nevus, plaque, agminate, linear, with satellitosis, disseminated, familial and targetoid. Read More

Med Clin (Barc) 2018 Jul 14;151(2):e11. Epub 2017 Nov 14.

Servicio de Dermatología, Hospital Universitari i Politécnic La Fe, Valencia, España.

Med Mycol 2018 Jun;56(4):395-405

Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taiwan.

Chromoblastomycosis (CBM) is an implantation mycosis characterized by the presence of pigmented muriform cells in tissue. CBM is endemic in Taiwan, but only three formal cases have been reported to date because of underreporting. To describe and update its epidemiologic features, we report a series of 30 cases between 2003 and 2016 at a single medical center. Read More

Indian J Dermatol Venereol Leprol 2017 Nov-Dec;83(6):656-662

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Background: Lichen planus pigmentosus (LPP) is a common cause of facial melanosis in the dark-skinned population. At present, information on dermoscopy and patch testing in LPP is limited.

Objectives: To describe dermoscopic findings and study the role of patch testing in patients with LPP on the face. Read More

Oman Med J 2017 Sep;32(5):429-431

Department of Medicine, Division of Gastroenterology and Hepatology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.

Tenofovir, a nucleotide analog, is one of the first-line medications recommended for the treatment of active chronic hepatitis B virus infection (CHB) and as a primary prophylaxis to prevent hepatitis B reactivation in cases of immunosuppression. We report the first case of tenofovir-induced leukocytoclastic vasculitis (LCV). A 43-year-old obese woman, who was known to have inactive CHB, was diagnosed with chronic immune thrombocytopenic purpura (ITP). Read More

Gastroenterology Res 2017 Aug 31;10(4):251-254. Epub 2017 Aug 31.

Department of Gastroenterology and Hepatology, The Brooklyn Hospital Center, Academic Affiliate of The Icahn School of Medicine at Mount Sinai, Clinical Affiliate of The Mount Sinai Hospital, 121 Dekalb Avenue, Brooklyn, NY 11201, USA.

Dermatomyositis (DM) is a rare autoimmune condition which predominantly affects females in the fifth and sixth decades of life. DM presents acutely or progressively as painless proximal skeletal muscle weakness and can be associated with a heliotropic rash around the eyes, and Gottron's papules on extensor surfaces of the hands. While the pathophysiology of DM is still unclear, abnormal T- and B-cell immune activity has been reported. Read More

Clin Rev Allergy Immunol 2017 Dec;53(3):439-451

Pediatric Department of Southern Switzerland, San Giovanni Hospital, 6500, Bellinzona, Switzerland.

In childhood, cutaneous small-vessel vasculitides include Henoch-Schönlein syndrome, a systemic vasculitis, and Finkelstein-Seidlmayer syndrome, a skin-limited vasculitis. Both Henoch-Schönlein and Finkelstein-Seidlmayer syndromes are seen more frequently in white or Asian compared with black children and occur especially in winter and spring with a male-to-female ratio of approximately 2:1. In everyday clinical practice, both conditions are diagnosed on clinical grounds without histological confirmation. Read More

Am J Dermatopathol 2017 May 26. Epub 2017 May 26.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL.

Australas J Dermatol 2017 Aug 28;58(3):e156-e157. Epub 2017 Jun 28.

Department of Dermatology, Complejo Hospitalario de Navarra, Pamplona, Spain.

Case Rep Infect Dis 2017 23;2017:6598043. Epub 2017 Apr 23.

Department of Internal Medicine, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA, USA.

Lyme disease (LD) is a tick-borne illness caused by . An 80-year-old female from Pennsylvania, USA, presented to an outside hospital with fever, confusion, lower extremity weakness, and stool incontinence. CT head and MRI spine were unremarkable. Read More

Australas J Dermatol 2018 May 12;59(2):135-137. Epub 2017 May 12.

Melanoma and Skin Cancer Unit, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Lancet Infect Dis 2017 05;17(5):562

Division of Infectious Disease, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA, USA.

Dermatol Pract Concept 2017 Jan 31;7(1):43-47. Epub 2017 Jan 31.

Institute of Histopathology, Histonor, Antofagasta, Chile.

Targetoid hemosiderotic hemangioma (THH) or hobnail hemangioma (HH) is a benign vascular lesion that presents with the classical clinical presentation of a ring-shaped tumor having a targetoid appearance, with a central purple-brown papule surrounded by a thin pale area and an ecchymotic ring on the outside. Dermoscopic features and patterns of HH have been documented and have proven to be sufficient to establish a clinical diagnosis in many cases. We present a facial lesion in which both the clinical presentation and dermoscopy were atypical. Read More

Br J Dermatol 2018 Mar 1;178(3):786-789. Epub 2017 Oct 1.

Departments of Dermatology, Hospital Universitario 12 de Octubre, I + 12 Research Institute, Universidad Complutense, Madrid, Spain.

A 65-year-old pluripathological woman attended our hospital with a cutaneous eruption of sudden appearance after vancomycin treatment. She presented targetoid lesions affecting approximately 25-30% of her body surface, large erosions with mucosal lesions and positive Nikolsky sign. Under the initial clinical suspicion of toxic epidermal necrolysis (TEN), and considering the recent literature of successful use of etanercept in these cases, she was treated with a single dose of this antitumour necrosis factor (anti-TNF) agent. Read More

Acta Dermatovenerol Croat 2016 Dec;24(4):307-309

Prof. Magdalena Czarnecka-Operacz, MD, PhD, Department of Dermatology, 49 Przybyszewski Str., 60-355 Poznań, Poland.

Dear Editor, Erythema multiforme is considered an acute skin condition, characterized by a self-limiting and sometimes recurrent course. It is regarded as a type IV hypersensitivity reaction associated with certain infections, medications, and other various triggers. Allergic contact dermatitis is in turn a delayed type of induced allergy as a result of cutaneous contact with a specific allergen to which the patient develops specific sensitivity. Read More

Pediatr Dermatol 2017 Jan 22;34(1):25-32. Epub 2016 Nov 22.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Spitz nevi are benign melanocytic neoplasms characterized by epithelioid or spindle melanocytes or both. In some rare cases their presentation overlaps with the clinical and histopathologic features of malignant melanoma, so a differential diagnosis can be difficult to make. Intermediate forms between Spitz nevi and malignant melanoma, with unpredictable behavior, have been called atypical Spitz tumors. Read More

J Cutan Med Surg 2017 Mar/Apr;21(2):164-166. Epub 2016 Oct 6.

1 Department of Dermatology, Complejo Hospitalario Universitario de Granada, Spain.

Hobnail hemangioma, also known as targetoid hemosiderotic hemangioma, is an uncommon vascular proliferation that clinically presents as a small solitary red to purple papule or macule, located on the limbs or trunk. Multiple lesions and atypical locations have been described. Histopathologically, it exhibits a biphasic pattern, with dilated vessels in the superficial dermis and angulated vessels in the deeper dermis, with endothelial cells that show a hobnail appearance. Read More

Am J Surg Pathol 2016 11;40(11):1526-1537

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Polymorphous low-grade adenocarcinoma (PLGA) shows histologic diversity with fascicular and targetoid features while cribriform adenocarcinoma of salivary gland (CASG) demonstrates predominant cribriform and solid patterns with glomeruloid appearance and optical clear nuclei. The current study is designed to identify pathologic features that may predict clinical outcome in 69 PLGA/CASG. Seven patients had recurrences or distant metastasis, including 3 local recurrences, 2 nodal metastases, and 2 distant metastases. Read More

Eur J Dermatol 2017 Feb;27(1):64-65

Division of Dermatology, Tohoku Medical and Pharmaceutical University, 1-12-1 Fukumuro, Miyagino-ku, Sendai 983-8512.

Indian J Dermatol Venereol Leprol 2017 May-Jun;83(3):408-410

Department of Pathology, Facultad de Medicina, Pontificia Universidaad Católica de Chile, Santiago, Chile.

J Am Acad Dermatol 2016 10;75(4):e129-e130

Department of Dermatology, Virginia Commonwealth University, Richmond, Virginia.

Acta Neuropathol 2016 09 2;132(3):475-8. Epub 2016 Aug 2.

Department of Neuropediatrics and NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Allergol Int 2017 Jan 8;66(1):36-41. Epub 2016 Jul 8.

Department of Dermatology, Nippon Medical School, Tokyo, Japan.

Toxic epidermal necrolysis (TEN) is a severe adverse drug reaction characterized by necrosis of the epidermis. Its incidence is approximately 1 per million a year and average mortality rate is high at 25-50%. TEN has a flu-like prodrome, followed by atypical, targetoid erythematous or purpuric macules on the skin. Read More

Semin Diagn Pathol 2016 Sep 13;33(5):284-93. Epub 2016 May 13.

Division of Surgical Pathology, University of Virginia Medical Center, Charlottesville, Virginia; Division of Cytopathology, University of Virginia Medical Center, Charlottesville, Virginia; Division of Autopsy Pathology, University of Virginia Medical Center, Charlottesville, Virginia. Electronic address:

Vascular proliferations in the skin have been thoroughly studied over the past 35 years, and a great deal of knowledge has been accrued regarding their pathobiological features. Dr. Juan Rosai has been a consistent contributor to the literature on this topic throughout most of his career, and this article reviews selected cutaneous endothelial lesions that he helped to characterize. Read More

J Med Assoc Thai 2015 Nov;98 Suppl 10:S147-9

Neonatal lupus erythematous (NLE) is a rare autoimmune disease caused by placental transfer of maternal anti-SSA/Ro or anti-SSB/La antibodies. It usually presents with transient cutaneous lesions, congenital heart block and other systemic symptoms. The authors report a case of neonatal lupus erythematosus who presented with targetoid-like lesions on both feet. Read More

Indian Pediatr 2016 May;53(5):425-6

Department of Dermatology and STD and *Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Dilshad Garden, Delhi, India. Correspondence to: Dr Deepika Pandhi, Professor, Department of Dermatology and STD, University College of Medical Sciences and associated GTB Hospital, Delhi 110 095, India.

Background: Post-vaccination infantile bullous pemphigod is a rare presentation.

Case Characteristics: A 2-month-old girl presented with widespread bullae, erosions, necrotic and targetoid lesions over body and mucosae after vaccination. Histology and direct immunofluorescence (DIF) were consistent with bullous pemphigoid. Read More

Pediatr Emerg Care 2018 Feb;34(2):e28-e29

We report a case of acute hemorrhagic edema of infancy (AHEI) occurred in an 11-month-old male infant after upper respiratory tract infection. The onset was dramatic with petechiae, ecchymosis, and annular, nummular, or targetoid purpuric plaques on the extremities, face, and ears. Acute hemorrhagic edema of infancy is a benign form of leukocytoclastic vasculitis that typically affects children between 4 and 24 months of age. Read More