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G Ital Dermatol Venereol 2018 Oct;153(5):685-691

Unit of Dermatology and Sexually-Trasmitted Diseases, P. Giaccone University Hospital, University of Palermo, Palermo, Italy.

Targetoid hemosiderotic hemangioma represents an uncommon, distinctive, benign lympho-vascular lesion, with a variable clinical appearance, typically occurs in the lower limbs and trunk. Most patients are in their 20's or 30's. We describe three dermoscopic cases followed by the review of the literature. Read More

Dermatol Pract Concept 2017 Jan 31;7(1):43-47. Epub 2017 Jan 31.

Institute of Histopathology, Histonor, Antofagasta, Chile.

Targetoid hemosiderotic hemangioma (THH) or hobnail hemangioma (HH) is a benign vascular lesion that presents with the classical clinical presentation of a ring-shaped tumor having a targetoid appearance, with a central purple-brown papule surrounded by a thin pale area and an ecchymotic ring on the outside. Dermoscopic features and patterns of HH have been documented and have proven to be sufficient to establish a clinical diagnosis in many cases. We present a facial lesion in which both the clinical presentation and dermoscopy were atypical. Read More

J Cutan Med Surg 2017 Mar/Apr;21(2):164-166. Epub 2016 Oct 6.

1 Department of Dermatology, Complejo Hospitalario Universitario de Granada, Spain.

Hobnail hemangioma, also known as targetoid hemosiderotic hemangioma, is an uncommon vascular proliferation that clinically presents as a small solitary red to purple papule or macule, located on the limbs or trunk. Multiple lesions and atypical locations have been described. Histopathologically, it exhibits a biphasic pattern, with dilated vessels in the superficial dermis and angulated vessels in the deeper dermis, with endothelial cells that show a hobnail appearance. Read More

J Cutan Med Surg 2016 May 16;20(3):216-20. Epub 2015 Oct 16.

Division of Pediatric Dermatology, Hospital for Sick Kids, Toronto, Canada.

Background: Hobnail hemangioma is a small benign vascular malformation of the superficial and mid-dermis with variable clinical presentation.

Objectives: To review the clinical characteristics of hobnail hemangioma in pediatric patients.

Methods: A retrospective chart review performed of all histopathologically confirmed cases of hobnail hemangioma from May 2000 to December 2014. Read More

Dermatology 2015 13;231(4):339-44. Epub 2015 Oct 13.

Dermatology Department, Hospital Sant Pau i Santa Tecla, Tarragona, Spain.

Background: Targetoid hemosiderotic hemangioma is an uncommon, vascular, benign solitary lesion of lymphatic origin that can be misdiagnosed as other tumors including melanomas.

Objectives: To evaluate the dermoscopic features of a large series of targetoid hemosiderotic hemangiomas.

Methods: Digital dermoscopic images of 35 histopathologically confirmed cases of targetoid hemosiderotic hemangiomas collected from 7 hospitals in Spain and Italy were evaluated for the presence of dermoscopic structures and patterns. Read More

J Am Acad Dermatol 2014 Nov 15;71(5):e179-81. Epub 2014 Oct 15.

Department of Dermatology and Venereology, Second University of Naples, Naples, Italy.

Indian Dermatol Online J 2014 Oct;5(4):559-60

Departments of Dermatology, Surgery, Dr. L. H. Hiranandani Hospital, Powai, Mumbai, Maharashtra, India.

An Bras Dermatol 2014 Nov-Dec;89(6):956-9

Hospital São Marcos, Teresina, PI, Brazil.

Targetoid Hemosiderotic Hemangioma, also known as Hobnail Hemangioma, is a lesion of vascular origin, probably lymphatic. The most common clinical feature is a solitary violaceous papule surrounded by a pale, thin area and a peripheral ecchymotic ring, simulating a target. Histopathologically, there is a biphasic pattern, with dilated vessels in the superficial dermis and pseudoangiosarcomatous pattern in the deep dermis, and endothelial cells with hobnail morphology. Read More

An Pediatr (Barc) 2015 Feb 5;82(2):111-2. Epub 2014 Jun 5.

Sección de Dermatología Pediátrica, Hospital Universitario La Paz, Madrid, España.

Pediatr Dermatol 2014 May-Jun;31(3):281-5. Epub 2014 Mar 6.

Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Hobnail hemangioma (HH), initially termed targetoid hemosiderotic hemangioma, is a rare, often solitary lesion classically characterized by a central brown or violaceous papulonodule surrounded at times by an ecchymotic halo. This lesion is typically found on the trunk or limbs of children or young to middle-aged adults. Numerous case reports have found HHs to have a reproducible histologic appearance. Read More

Cutis 2013 Aug;92(2):91-3

700 W Jefferson St, Kirksville, MO 63501, USA.

Targetoid hemosiderotic hemangioma (THH) is a benign vascular tumor characterized by a central violaceous papule with a clear periphery bordered by an ecchymotic ring. Originally coined by its characteristic halo appearance with hemosiderin deposits, not all THHs have this classic halo or hemosiderin composition. We report a unique case of THH in which the patient presented with multiple lesions with no prior trauma. Read More

Chin Med J (Engl) 2013 ;126(17):3399

Department of Dermatology, Beijing Hospital, Beijing 100730, China.

Ann Dermatol 2011 Nov 3;23(4):539-43. Epub 2011 Nov 3.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

Hobnail hemangioma (targetoid hemosiderotic hemangioma) is a vascular tumor affecting the limbs or trunk. Characteristically, the lesion has a "targetoid" clinical feature and dilated vascular spaces lined by hobnail endothelial cells at histologic examination. The age of onset is widely variable, form 5~67 years, typically occurring in young or middle-aged persons. Read More

J Am Acad Dermatol 2012 Jan 27;66(1):116-20. Epub 2011 Jul 27.

Division of Dermatology, CHU Sainte Justine, University of Montreal, Montreal, Quebec, Canada.

Background: Targetoid hemosiderotic hemangioma (THH), also called hobnail hemangioma, is a benign vascular lesion and thought to be of lymphatic origin.

Objective: We sought to perform a clinicopathologic analysis of cases diagnosed as THH in a tertiary care children's hospital.

Methods: Clinical and histopathologic data were obtained from a chart review of 12 confirmed pediatric cases of THH. Read More

J Am Osteopath Assoc 2011 Feb;111(2):117-8

Department of Aviation Medicine, Naval Hospital Oak Harbor, 3475 N Saratoga St, Oak Harbor, WA 98278-4927, USA.

A 26-year-old previously healthy man presented with a 6-mm violaceous papule that had a surrounding 1.5-cm annular, nonblanching, erythematous halo on the right-sided flank. The man reported the lesion had been recurring for 4 to 5 years, flaring every 4 to 5 months and then slowly disappearing until the cycle recurred. Read More

J Am Acad Dermatol 2010 Dec;63(6):1052-7

Division of Dermatology, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.

Background: Vascular tumors and malformations can be challenging to diagnose. Although they may initially appear very similar, they have distinct clinical courses and management. Wilms tumor 1 (WT1) gene expression has been reported in many different tumors including hematologic malignancies and some solid tumors. Read More

Int J Dermatol 2008 Oct;47(10):991-2

Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.

Bratisl Lek Listy 2008 ;109(3):141-3

Anatomic Pathology, Hospital El Bierzo, Clinica Ponferrada, Ponferrada, Spain.

Hobnail hemangioma (HH) was known in the past as targetoid hemosiderotic hemangioma (THH). We present a case that meets the criteria of HH in a 34-year-old woman. The lesion presented as a reddish papule on her left hip. Read More

Acta Derm Venereol 2008 ;88(2):181-2

J Eur Acad Dermatol Venereol 2007 Feb;21(2):267-9

Arch Dermatol 2006 Oct;142(10):1351-6

Medical College of Georgia, Augusta, USA.

J Cutan Pathol 2004 May;31(5):362-7

Department of Pathology, Justus-Liebig University of Giessen, Langhanstrasse 10, D-35392 Giessen, Germany.

Background: Hobnail hemangioma (targetoid hemosiderotic hemangioma) is a small benign vascular tumor of the superficial and mid-dermis. In contrast to its well-characterized histology, it has been unclear whether this tumor arises from blood vessel endothelial cells (BECs) or lymphatic vessel endothelial cells (LECs).

Methods: We analyzed 10 hobnail hemangiomas by immunohistochemistry, using the recently described lymphatic endothelial cell marker, D2-40. Read More

Cutis 2003 Jul;72(1):24, 51-2

Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.

Am J Dermatopathol 2001 Jun;23(3):221-3

Department of Dermatology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA.

Reported here is a 15-year-old with lesions demonstrating histologic features of targetoid hemosiderotic hemangioma (THH) developing after trauma to inflammatory lesions. These lesions pose as simulators of THH. Targetoid hemosiderotic hemangioma is a benign vascular lesion first described by Santa Cruz and Aaronburg. Read More

Arch Dermatol 2000 Dec;136(12):1571-2

J Cutan Pathol 1999 Jul;26(6):279-86

Department of Pathology, University of Jena, Germany.

Hobnail hemangioma, also known as "targetoid hemosiderotic hemangioma", represents a distinctive, benign vascular tumor, characterized histologically by a biphasic growth pattern of dilated vascular structures in the superficial dermis lined by prominent hobnail endothelial cells, and collagen dissecting, rather narrow neoplastic vessels in deeper parts of the lesion. We analyzed the clinicopathologic and immunohistochemical features in a series of 62 cases. Patient age range was 6-72 years (median: 32 years); 34 patients were male and 25 female. Read More

J Am Acad Dermatol 1999 Aug;41(2 Pt 1):215-24

Divison of Dermatology, Department of Pathology, Albany, NY 12208, USA.

Background: Both targetoid hemosiderotic hemangiomas (THH) and solitary angiokeratomas (SAK) are acquired vascular malformations formed by superficial vascular ectasias possibly caused by trauma.

Objective: We compare the clinicopathologic findings of THHs with those of SAKs and report the clinicopathologic findings of 3 singular cases of THH affected by cyclic or episodic morphologic changes.

Methods: We performed a clinicopathologic study on 33 cases of THH and compared this group with 20 cases of SAK. Read More

Eur J Dermatol 1998 Dec;8(8):583; discussion 584-5

Department of Dermatology, Haut-Lévêque Hospital, Pessac, France.

Am J Surg Pathol 1999 Jan;23(1):97-105

University Institute of Pathology, Lausanne, Switzerland.

The clinicopathologic features of 15 cutanous hemangiomas having a distinctive and frequently pseudomalignant morphologic appearance are presented. There were 5 male and 9 female patients, whose ages at diagnosis ranged from 11 to 58 years (median 30.5). Read More

J Eur Acad Dermatol Venereol 1998 Sep;11(2):186-7

J Am Acad Dermatol 1997 Dec;37(6):887-919; quiz 920-2

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

This second part of our review about vascular proliferations summarizes the clinicopathologic features of the cutaneous vascular hyperplasias and benign neoplasms. Hyperplasias comprise a heterogeneous group of vascular proliferations that eventually show a tendency to regression. Angiolymphoid hyperplasia with eosinophilia is included within the group of hyperplasias because of its historical denomination and its reactive nature, probably as a consequence of an arteriovenous shunt, although usually the lesions do not regress. Read More

Am J Dermatopathol 1997 Feb;19(1):16-22

Institute of Histopathology and Anatomical Pathology, University of Sassari, Italy.

The clinical and pathological features of seven cases of lymphangioma-like Kaposi's sarcoma (KS) are reported. As with the other subtypes of KS, the lymphangioma-like variant occurs more often in men aged 59-80 years. Clinically, the lesion appears intermingled with the classical forms of KS, but a "bulla-like" appearance recognized in seven of 13 cases has been considered as a clinical hallmark of this variant. Read More

Dermatology 1995 ;191(2):154-6

Department of Pathology, Hospital del Niño Jesús, Madrid, Spain.

We report a case of hobnail hemangioma presenting as a congenital 2-mm brownish papule on the face of an 11-year-old girl. Hobnail hemangiomas have recently been characterized as a group, and they are related to the so-called targetoid hemosiderotic hemangiomas. Immunohistochemical data (positivity for factor VIII-related antigen, CD-34 and CD-31) support a vascular origin. Read More

Ann Dermatol Venereol 1995 ;122(3):111-4

Service d'Anatomie Pathologique, Hôpital Pasteur, Nice.

Introduction: Targetoid hemosiderotic hemangioma (THH) is a new vascular disorder, rarely reported. The lesion presents as violaceous papule surrounded by an ecchymotic ring usually measuring less than 1 cm in diameter. Epithelioid endothelial cells with a hobnail appearance, vascular papillary projections and hemosiderin deposits are the histological hallmarks of this entity. Read More

J Cutan Pathol 1994 Dec;21(6):567-9

Hautarzt 1994 Jan;45(1):34-7

Universitäts-Hautklinik Heidelberg.

Targetoid haemosiderotic haemangioma (THH) can be differentiated from other angiomatous lesions by the characteristic findings on clinical and histological examination. Clinically the solitary lesion is suggestive of a melanocytic or angiomatous origin, surrounded by a haemorrhagic halo in the acute phase. Histological findings vary depending on the duration of the alteration. Read More

Dermatology 1992 ;184(4):300-2

Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

A new case of hemosiderotic targetoid hemangioma is reported. The literature is briefly reviewed. Read More

J Cutan Pathol 1990 Aug;17(4):233-5

Department of Dermatology, University of Texas Medical School, Houston 77030.

A case of targetoid hemosiderotic hemangioma on the buttock of a 20-year-old pregnant woman is presented. Eight cases of this newly-described entity were initially reported by Santa Cruz and Aronberg in 1988. It is important to distinguish these vascular lesions from Kaposi's sarcoma, epithelioid hemangioma, and progressive lymphangioma. Read More

J Am Acad Dermatol 1988 Sep;19(3):550-8

Department of Pathology, Washington University School of Medicine, St. Louis, MO.

We describe a vascular lesion with characteristic clinical and histologic features. The patients when first seen have a small, single, annular, targetoid-appearing lesion. Histologically it is a noncircumscribed vascular proliferation that may extend into the subcutaneous tissue. Read More