291,672 results match your criteria Targeted Cancer Therapy
Cell Physiol Biochem 2018 Dec 6;51(5):2123-2135. Epub 2018 Dec 6.
Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou,
Background/aims: Emerging evidence suggests a close link between gut microbiota and non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the association between gut microbiota and the DNA methylation of adiponectin (an adipocyte-specific adipocytokine) in rats, following diet-induced NAFLD.
Methods: 50 male SD rats were randomly divided into five groups with or without a high fat diet (HFD), antibiotics, and probiotics, in order to establish an imbalanced gut microbiota and probiotic treatment model in NAFLD rats. Read More
Cell Physiol Biochem 2018 Dec 6;51(5):2136-2147. Epub 2018 Dec 6.
Background/aims: Long non-coding RNAs (lncRNAs) play vital roles in carcinogenesis as oncogenes or tumor suppressor genes. This study explored the biological function of lncRNA gastric adenocarcinoma predictive long intergenic non-coding RNA (GAPLINC) in human non-small cell lung cancer (NSCLC).
Methods: GAPLINC expression in NSCLC specimens and cell lines was detected by qRT-PCR and Western blot. Read More
J Environ Manage 2018 Dec 3;232:636-653. Epub 2018 Dec 3.
Institute for Water Quality and Resource Management, TU Wien, Karlsplatz 13/226, 1040, Vienna, Austria.
Occurrence and concentration of a broad spectrum of micropollutants are investigated in Austrian river catchments, namely polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), organotin compounds, perfluoroalkyl acids (PFAAs) and metals. The parallel analysis across multiple environmental and engineered compartments sheds light on the ratio of dissolved and particulate transport and on differences in concentration levels between point and diffuse emission pathways. It is found that some PAHs and organotins are present in rivers, groundwater and bulk deposition at higher concentrations than in municipal wastewater effluents. Read More
Int J Infect Dis 2018 Dec 3. Epub 2018 Dec 3.
Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway.
Introduction: Anthrax is caused by the spore-forming, Gram-positive bacterium Bacillus anthracis. The aim of the study was to predict the potential distribution of B. anthracis in Tanzania and produce epidemiological evidence for management of anthrax outbreaks in the country. Read More
Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 3. Epub 2018 Dec 3.
Lipids and Atherosclerosis Research Unit, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Universitat Rovira i Virgili, Reus, Spain. Electronic address:
Aims: The aim of this study is to determine the physical and functional interplay between fatty acid-binding protein 4 (FABP4) and its membrane receptor-like candidate protein, cytokeratin 1 (CK1), and to determine the effect of hindering CK1-mediated FABP4 cellular uptake on non-disturbed or metabolically stressed endothelial cells.
Methods: We monitored the direct interaction between FABP4 and CK1 using surface plasmon resonance, and the effects of blocking exogenous FABP4 (eFABP4) cellular uptake were determined by using specific siRNA to knock down the expression of CK1 in human umbilical vein endothelial cells (HUVECs). The expression and nuclear translocation of transcription factors involved in oxidative stress (NRF2) and inflammation (p65 subunit of NF-ĸB transcription factor) were determined by Western blotting analysis. Read More
Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.
Department of Medical Oncology, CAncer Research for PErsonalized Medicine (CARPEM), Paris Centre Teaching Hospitals, Paris Descartes University, USPC, Paris, France.
Body composition has gained increasing attention in oncology in recent years due to fact that sarcopenia has been revealed to be a strong prognostic indicator for survival across multiple stages and cancer types and a predictive factor for toxicity and surgery complications. Accumulating evidence over the last decade has unraveled the "pharmacology" of sarcopenia. Lean body mass may be more relevant to define drug dosing than the "classical" body surface area or flat-fixed dosing in patients with cancer. Read More
Cell Signal 2018 Dec 3. Epub 2018 Dec 3.
Division of Cell Matrix Biology & Regenerative Medicine, UK. Electronic address:
Photodamage in chronically sun-exposed skin manifests clinically as deep wrinkles and histologically as extensive remodelling of the dermal extracellular matrix (ECM) and in particular, the elastic fibre system. We have shown previously that loss of fibrillin microfibrils, a key elastic fibre component, is a hallmark of early photodamage and that these ECM assemblies are susceptible in vitro to physiologically attainable doses of ultraviolet radiation (UVR). Here, we test the hypotheses that UVR-mediated photo-oxidation is the primary driver of fibrillin microfibril and fibronectin degradation and that prior UVR exposure will enhance the subsequent proteolytic activity of UVR-upregulated matrix metalloproteinases (MMPs). Read More
J Control Release 2018 Dec 3. Epub 2018 Dec 3.
Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Aachen, Germany; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, the Netherlands; Department of Targeted Therapeutics, Biomaterial Science and Technology, University of Twente, Enschede, the Netherlands. Electronic address:
Public Health Rep 2018 Dec 6:33354918815183. Epub 2018 Dec 6.
2 Health Data Research, Analysis and Mapping Center at Western Michigan University, Kalamazoo, MI, USA.
Objectives:: The incidence of gestational diabetes mellitus (GDM) in the United States has increased during the past several decades. The objective of this study was to use birth records and a combination of statistical and geographic information system (GIS) analyses to evaluate GDM rates among subgroups of pregnant women in Michigan.
Materials And Methods:: We obtained data on maternal demographic and health-related characteristics and regions of residence from 2013 Michigan birth records. Read More
ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.
Although there is a large number of studies available evaluating the therapeutic efficacy of targeted polymeric nanoparticles, little is known about the critical attributes that can further influence their uptake into target cells. In this study, varying cRGD ligand densities (0-100% surface functionalization) were combined with different PEG spacer lengths (2/3.5/5kDa) and the specific receptor binding of targeted core-shell structured PLGA/PLA-PEG nanoparticles was evaluated using αβ integrin overexpressing U87MG glioblastoma cells. Read More
PLoS One 2018 6;13(12):e0208402. Epub 2018 Dec 6.
Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
Background: Malaysia has a comprehensive, publicly-funded immunization program for hepatitis B (HepB) among infants, but adults must pay for the vaccine. The number of HepB carriers among adults is expected to increase in the future; therefore, we examined the impact of five constructs (cues to action, perceived barriers, perceived benefit, perceived severity, and perceived susceptibility) on adults' willingness to pay (WTP) for HepB vaccine; secondarily, we examined the association between perceived barriers and perceived benefits.
Methods: Adults were selected through a stratified, two-stage cluster community sample in Selangor, Malaysia. Read More
PLoS One 2018 6;13(12):e0208321. Epub 2018 Dec 6.
Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn, New York, United States of America.
Increased proinflammatory interleukin-6 (IL-6) levels are associated with acquired long QT-syndrome (LQTS) in patients with systemic inflammation, leading to higher risks for life-threatening polymorphic ventricular tachycardia such as Torsades de Pointes. However, the functional and molecular mechanisms of this association are not known. In most cases of acquired LQTS, the target ion channel is the human ether-á-go-go-related gene (hERG) encoding the rapid component of the delayed rectifier K current, IKr, which plays a critical role in cardiac repolarization. Read More
PLoS One 2018 6;13(12):e0208323. Epub 2018 Dec 6.
Infectious Diseases, Prince of Wales Hospital, Sydney, NSW, Australia.
Background: Treatment as prevention approaches for HIV require optimal HIV testing strategies to reduce undiagnosed HIV infections. In most settings, HIV testing strategies still result in unacceptably high rates of missed and late diagnoses. This study aimed to identify clinical opportunities for targeted HIV testing in persons at risk to facilitate earlier HIV diagnosis in New South Wales, Australia; and to assess the duration between the diagnosis of specific conditions and HIV diagnosis. Read More
PLoS One 2018 6;13(12):e0208395. Epub 2018 Dec 6.
INRA PACA, UR 1052, GAFL unit (Génétique et Amelioration des Fruits et Légumes), Avignon, France.
Targeted insertion of transgenes in plants is still challenging and requires further technical innovation. In the present study, we chose the tomato DFR gene involved in anthocyanin biosynthesis as a landing pad for targeted transgene insertion using CRISPR-Cas9 in a two-step strategy. First, a 1013 bp was deleted in the endogenous DFR gene. Read More
PLoS One 2018 6;13(12):e0208171. Epub 2018 Dec 6.
Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Background: Cystic fibrosis (CF) is a disorder affecting the respiratory, digestive, reproductive systems and sweat glands. This lethal hereditary disease has known or suspected links to the dysbiosis gut microbiota. High-throughput meta-omics-based approaches may assist in unveiling this complex network of symbiosis modifications. Read More
PLoS One 2018 6;13(12):e0208207. Epub 2018 Dec 6.
Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.
Background: After transplantation, cell-free DNA derived from the donor organ (ddcfDNA) can be detected in the recipient's circulation. We aimed to quantify ddcfDNA levels in plasma of kidney transplant recipients thereby investigating the kinetics of this biomarker after transplantation and determining biological variables that influence ddcfDNA kinetics in stable and non-stable patients.
Materials And Methods: From 107 kidney transplant recipients, plasma samples were collected longitudinally after transplantation (day 1-3 months) within a multicenter set-up. Read More
PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006890. Epub 2018 Dec 6.
World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland.
Background: Human African trypanosomiasis (HAT) is a neglected tropical disease targeted for elimination 'as a public health problem' by 2020. The indicators to monitor progress towards the target are based on the number of reported cases, the related areas and populations exposed at various levels of risk, and the coverage of surveillance activities. Based on data provided by the National Sleeping Sickness Control Programmes (NSSCP), Non-Governmental Organizations (NGOs) and research institutions-and assembled in the Atlas of HAT-the World Health Organization (WHO) provides here an update to 2016 for these indicators, as well as an analysis of the epidemiological situation. Read More
Ther Drug Monit 2018 Dec 4. Epub 2018 Dec 4.
Departments of Internal Medicine, Division of Nephrology and Transplantation and.
Background: There is an unmet need for reliable minimally invasive diagnostic biomarkers for immunological allograft monitoring and for the detection of acute kidney transplant rejection. Here, targeted proteomic analysis was applied to compare 92 proteins in sera of belatacept-treated patients who had biopsy-proven, acute T cell-mediated rejection (aTCMR) with patients without aTCMR.
Methods: Proximity extension immunoassay (PEA) was used to measure 92 inflammation-related protein concentrations in the pre-rejection and rejection sera of 11 patients with aTCMR and 9 patients without aTCMR. Read More
J Glob Oncol 2018 Dec(4):1-11
H. Kim Lyerly, Duke University, Durham, NC; Jun Ren, Capital University Medical Center; Zhimin Yang, China Food and Drug Administration, Beijing, People's Republic of China; Gi Hyun Kim, Korea Ministry of Food and Drug Safety, Seoul, South Korea; Sumimasa Nagai, University of Tokyo; Sumimasa Nagai, Tomohiro Yamaguchi, and Ken Hatogai, Pharmaceuticals and Medical Devices Agency; Hiroshi Katayama, National Cancer Center Hospital, Tokyo, Japan; Silvy Da Rocha Dias, European Medicines Agency, London, United Kingdom; Daniel McManus and Kathy Soltys, Health Canada, Ottawa, Ontario, Canada; Olufumilayo Olopade, University of Chicago, Chicago, IL; Nancy Goodman, Kids V Cancer, Washington, DC; Greg Reaman, US Food and Drug Administration; Thomas Gross, US National Cancer Institute, Bethesda, MD, and Renzo Canetta, Independent Consultant.
Advances in genetic sequencing and other diagnostic technologies have enabled the use of precision medicine in clinical cancer care, as well as the development of novel therapies that are targeted to specific molecular drivers of cancer. Developing these new agents and making them accessible to patients requires global clinical studies and regulatory review and approval by different national regulatory agencies. Whereas these global trials present challenges for drug developers who conduct them and regulatory agencies who oversee them, they also raise practical issues about patients with low-frequency cancers who need these therapies. Read More
Pathog Glob Health 2018 Dec 6:1-9. Epub 2018 Dec 6.
a Heidelberg Institute of Global Health , University of Heidelberg , Germany.
This review discusses biological and chemical methods for dengue vector control, using recently emerging summary evidence, meta-analyses and systematic reviews to conclude on practical public health recommendations for Aedes control, which is increasingly relevant in an era of widespread Chikungunya, yellow feer and Zika outbreaks. The analysis follows an a priori framework of systematic reviews by the authors on vector control methods, distinguishing vector control methods into biological, chemical and environmental methods. Findings of each published systematic review by the authors, following each individual vector control method, are summarised and compared in the discussion against the findings of existing meta-analyses covering all vector control methods. Read More
FASEB J 2018 Dec 6:fj201800885RR. Epub 2018 Dec 6.
Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Protein tyrosine (Tyr) nitration, the covalent addition of a nitro group (NO) to Tyr residues, is emerging as a candidate mechanism of endothelial dysfunction. Previous studies have shown that Tyr nitration is primarily induced by nitrosative stress, a process characterized by the production of reactive nitrogen species, especially peroxynitrite anion (ONOO), which is considered a secondary product of NO in the presence of superoxide radicals (O). However, the impact of nitrosative stress-induced Tyr nitration on endothelial dysfunction has not been thoroughly elucidated to date. Read More
Mol Pharm 2018 Dec 6. Epub 2018 Dec 6.
A number of cancer-targeting peptide-drug conjugates (PDCs) have been explored as alternatives to antibody-drug conjugates (ADCs) for targeted cancer therapy. However, the much shorter circulation half-life of PDCs compared with ADCs in vivo has limited their therapeutic value and thus their translation into the clinic, highlighting the need to develop new approaches for extending the half-life of PDCs. Here, we report a new strategy for targeted cancer therapy of a PDC based on a molecular hybrid between an anti-hapten antibody and a hapten-labeled PDC. Read More
Nano Lett 2018 Dec 6. Epub 2018 Dec 6.
Dual targeted delivery of drugs and energy by nanohybrids can potentially alleviate side effects and improve the unique features required for precision medicine. To realize this aim, however, the hybrids which are often rapidly removal from circulation and piled up tumors periphery near the blood vessels must address the difficulties in low blood half-lives and tumor penetration. In this study, a sponge-inspired carbon composites-supported red blood cell (RBC) membrane that doubles as a stealth agent and photolytic carrier that transports tumor-penetrative agents (graphene quantum dots and docetaxel (GQD-D)) and heat with irradiation was developed. Read More
Nano Lett 2018 Dec 6. Epub 2018 Dec 6.
The targeted delivery of therapeutics to sites of rheumatoid arthritis (RA) has been a long-standing challenge. Inspired by the intrinsic inflammation-targeting capacity of macrophages, macrophage-derived microvesicle (MMV)-coated nanoparticle (MNP) was developed for targeting RA. MMV was efficiently produced through a novel method. Read More
Plant Biotechnol J 2018 Nov 22. Epub 2018 Nov 22.
Centre for Research in Agricultural Genomics (CRAG, CSIC-IRTA-UAB-UB), Cerdanyola del Vallès, Spain.
Fungi that infect plants, animals or humans pose a serious threat to human health and food security. Antifungal proteins (AFPs) secreted by filamentous fungi are promising biomolecules that could be used to develop new antifungal therapies in medicine and agriculture. They are small highly stable proteins with specific potent activity against fungal pathogens. Read More
Depress Anxiety 2018 Dec 6. Epub 2018 Dec 6.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Background: Major depressive disorder (MDD) in college students is associated with substantial burden.
Aims: To assess 1-year incidence of MDD among incoming freshmen and predictors of MDD-incidence in a representative sample of students.
Method: Prospective cohort study of first-year college students (baseline: n = 2,519, 1-year follow-up: n = 958) RESULTS: The incidence of MDD within the first year of college was 6. Read More
Cancer 2018 Dec 6. Epub 2018 Dec 6.
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
Background: Depression is highly prevalent in lung cancer. Although there is a known association between inflammation and depression, this relationship has not been examined in patients with lung cancer who undergo treatment with immune and other targeted drug therapies. Peripheral blood C-reactive protein (CRP), a marker of systemic inflammation, may help identify metastatic lung cancer patients with inflammation-associated depression. Read More
Depress Anxiety 2018 Dec 6. Epub 2018 Dec 6.
School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.
Background: Numerous studies have suggested associations between depression and cardiometabolic (CM) diseases. However, little is known about the mechanism underlying this comorbidity, and whether the relationship differs by depression subtypes.
Methods: Using polygenic risk scores (PRS) and linkage disequilibrium (LD) score regression, we investigated the genetic overlap of various depression-related phenotypes with a comprehensive panel of 20 CM traits. Read More
Cancer 2018 Dec 6. Epub 2018 Dec 6.
Department of Radiation and Cellular Oncology, The University of Chicago Medicine, Chicago, Illinois.
The term "oligometastatic prostate cancer" refers to a heterogeneous group of disease states currently defined solely on the basis of clinical features. Oligorecurrent disease, de novo oligometastases, and oligoprogressive disease likely have unique biologic underpinnings and natural histories. Evidence suggesting the existence of a subset of patients who harbor prostate cancer with limited metastatic potential currently includes disparate and overwhelmingly retrospective reports. Read More
J Fish Dis 2018 Dec 6. Epub 2018 Dec 6.
Institute of Aquaculture, University of Stirling, Stirling, UK.
Flavobacterium psychrophilum is one of the most important pathogens affecting cultured rainbow trout (Oncorhynchus mykiss). Recent information from UK salmonid farms showed country-wide distribution of genetically and serologically divergent clones, which has hampered the development of a vaccine for rainbow trout fry syndrome. The current study assessed the efficacy of an injectable polyvalent vaccine containing formalin-inactivated F. Read More
Syst Biol 2018 Dec 6. Epub 2018 Dec 6.
Museum of Natural Science, Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA.
Resolving patterns of ancient and rapid diversifications is one of the most challenging tasks in evolutionary biology. These difficulties arise from confusing phylogenetic signals that are associated with the interplay of incomplete lineage sorting and homoplasy. Phylogenomic analyses of hundreds, or even thousands, of loci offer the potential to resolve such contentious relationships. Read More
Clin Infect Dis 2018 Dec 6. Epub 2018 Dec 6.
Department of Medicine, Harvard Medical School, Boston, MA, USA.
Immunotherapy using antibodies to immune checkpoint molecules or targeted chimeric antigen receptor-modified T (CAR-T) cells represent dramatic advances in cancer treatment. These therapies mediate immune-related adverse events (irAEs) which may mimic or amplify infectious presentations. Checkpoint inhibitor therapy may be associated with diverse irAEs including mild skin, endocrine and autoimmune manifestations or severe inflammatory processes including colitis, pneumonitis, myocarditis, and shock. Read More
Org Biomol Chem 2018 Dec 6. Epub 2018 Dec 6.
Tianjin Key Laboratory for Photoelectric Materials and Devices, and Key Laboratory of Display Materials and Photoelectric Devices, Ministry of Education, School of Materials Science & Engineering, Tianjin University of Technology, Tianjin 300384, China. and School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.
Hypochlorous acid (HOCl) has been known to be intertwined with various pathophysiological processes. In this paper, a novel mitochondria-targeted near-infrared (NIR) fluorescent probe L based on a chromenylium-phenothiazine conjugate has been designed and synthesized for the detection of hypochlorous acid. Due to the HOCl-promoted intramolecular charge transfer processes, the probe L shows near-infrared fluorescence emission at 672 nm, large Stokes shifts of 97 nm, fast response, and high selectivity and sensitivity. Read More
Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.
Rare Cancer Center.
NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors. Because they occur only in a small subset of mesenchymal tumors, knowledge regarding the corresponding histology is important to effectively identify patients who could benefit from targeted therapy. In this study, using RNA sequencing, we identified novel NTRK3 fusions involving related partner genes in 2 adult bone and soft tissue tumors that met the current histologic criteria of fibrosarcoma. Read More
Curr Opin Obstet Gynecol 2018 Dec 5. Epub 2018 Dec 5.
Department of Hematology, Oncology and Tumour Immunology, Charité University Hospital Berlin, Campus Benjamin Franklin, Berlin, Germany.
Purpose Of Review: Over the last decades the time which is needed to translate a preclinical finding or idea in the clinic has reduced continuously. Especially but not only for breast cancer the number of tested drugs and targeted pathways have increased immensely. In addition, the introduction of immune-oncological treatments has further advanced the possibilities for future treatments. Read More
Curr Opin Psychiatry 2018 Dec 5. Epub 2018 Dec 5.
Dementia Centre for Research Collaboration, School of Psychiatry, UNSW Sydney, Sydney.
Purpose Of Review: Although young onset dementia (YOD) causes high levels of burden and distress, factors that contribute to its onset are not well understood. Identifying relevant modifiable risk and protective factors for YOD can inform efforts to prevent or delay onset of symptoms to later in life.
Recent Findings: Studies of modifiable factors for YOD have increased in frequency in recent years. Read More
Elife 2018 Dec 6;7. Epub 2018 Dec 6.
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, United States.
The Dcp1-Dcp2 decapping enzyme and the decapping activators Pat1, Dhh1, and Lsm1 regulate mRNA decapping, but their mechanistic integration is unknown. We analyzed the gene expression consequences of deleting or or the C-terminal domain, and found that: i) the Dcp2 C-terminal domain is an effector of both negative and positive regulation; ii) rather than being global activators of decapping, Pat1, Lsm1, and Dhh1 directly target specific subsets of yeast mRNAs and loss of the functions of each of these factors has substantial indirect consequences for genome-wide mRNA expression; and iii) transcripts targeted by Pat1, Lsm1, and Dhh1 exhibit only partial overlap, are generally translated inefficiently, and, as expected, are targeted to decapping-dependent decay. Our results define the roles of Pat1, Lsm1, and Dhh1 in decapping of general mRNAs and suggest that these factors may monitor mRNA translation and target unique features of individual mRNAs. Read More
Pacing Clin Electrophysiol 2018 Dec 6. Epub 2018 Dec 6.
University of California Los Angeles, Department of Cardiothoracic Surgery, UCLA Medical Center, Los Angeles, CA.
Background: Patients with systemic right ventricles (RV) often develop progressive heart failure and may benefit from cardiac resynchronization therapy (CRT), however the optimal strategy for CRT has not been defined.
Methods: A retrospective review of all patients with systemic RV failure undergoing a hybrid transcatheter-surgical approach was performed. Procedural technique and outcomes are reported. Read More
Rev Recent Clin Trials 2018 Dec 5. Epub 2018 Dec 5.
Division of Medical Oncology, AORN Giuseppe Moscati, Avellino. Italy.
Background: Lung cancer is the leading cause of cancer mortality, being responsible for more than 1.6 million deaths each year worldwide and non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancers; moreover, 10 to 15% of all NSCLCs harbors EGFR (epidermal growth factor receptor) activating mutations, being suitable for EGFR-Tyrosine Kinase Inhibitors (TKI) molecular targeted therapy. However, EGFR+ NSCLCs gain acquired resistance to these agents, representing one of the key challenges for modern precision oncology. Read More
Future Med Chem 2018 Dec 6. Epub 2018 Dec 6.
Aix Marseille Univ, CNRS, Cent Marseille, ISM2, Marseille, France.
Aim: E-selectin is overexpressed on angiogenic and inflamed endothelium. Molecules binding to E-selectin with high affinity and specificity enable its use as a molecular imaging biomarker.
Material & Methods: The interactions of four different peptides (i. Read More
Proteomics Clin Appl 2018 Dec 6:e1700168. Epub 2018 Dec 6.
University of Bremen, Bremen, Germany.
Purpose: To develop a mass spectrometry imaging (MSI) based workflow for extracting m/z values related to putative protein biomarkers and using these for reliable tumor classification.
Experimental Design: Given a list of putative breast and ovarian cancer biomarker proteins, we extracted a set of related m/z values from heterogeneous MSI datasets derived from formalin-fixed paraffin-embedded tissue material. Based on these features, a linear discriminant analysis classification model was trained to discriminate the two tumor types. Read More
Chembiochem 2018 Dec 5. Epub 2018 Dec 5.
University of Texas at Austin, Chemistry, 105 E 24th St Stop A5300, 78712, Austin, UNITED STATES.
One-third of all proteins are estimated to require metals for structural stability and/or catalytic activity. Desthiobiotin probes containing metal binding groups can be used to capture metalloproteins with exposed active-site metals under mild conditions to prevent changes in metallation state. The proof-of-concept was demonstrated with carbonic anhydrase (CA), an open active site, Zn-containing protein. Read More
Cell Prolif 2018 Dec 5:e12552. Epub 2018 Dec 5.
Department of Urology, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.
With the development of synthetic biology, synthetic gene circuits have shown great applied potential in medicine, biology, and as commodity chemicals. An ultimate challenge in the construction of gene circuits is the lack of effective, programmable, secure and sequence-specific gene editing tools. The clustered regularly interspaced short palindromic repeat (CRISPR) system, a CRISPR-associated RNA-guided endonuclease Cas9 (CRISPR-associated protein 9)-targeted genome editing tool, has recently been applied in engineering gene circuits for its unique properties-operability, high efficiency and programmability. Read More
Mol Carcinog 2018 Dec 5. Epub 2018 Dec 5.
Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Several studies have implicated the feedback activation of signal transducer and activator of transcription 3 (STAT3) as a new cancer drug-resistance mechanism and linked it to the failure of epidermal growth factor receptor (EGFR)-targeted therapies. In this study we discovered that Alantolactone, a natural sesquiterpene lactone, potently inhibited human pancreatic cancer cells and suppressed constitutively activated STAT3. In contrast, Alantolactone had little effect on the EGFR pathway. Read More
J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.
Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China.
Glioma is the most aggressive malignant tumor in the adult central nervous system. Abnormal long noncoding RNA (lncRNA) FOXD2-AS1 expression was associated with tumor development. However, the possible role of FOXD2-AS1 in the progression of glioma is not known. Read More
Pediatr Dermatol 2018 Dec 5. Epub 2018 Dec 5.
Department of Dermatology, University of Utah, Salt Lake City, Utah.
As skin cancer rates continue to rise, targeted efforts to reduce excessive exposure to ultraviolet radiation are crucial. Adolescents are a high-risk population for intentional tanning; thus, we sought to determine whether the novel use of skin age analysis with ultraviolet (UV) photography would be an effective tool for reducing intentions to tan in adolescents with a calculated skin age (measured by complexion analysis software) that exceeds their actual age. Surveying 85 students in this study, skin age difference above zero was associated with reduced intentions to tan (P = 0. Read More
J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.
Department of Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
Breast cancer is the most prevalent cancers worldwide and causes a significant amount of deaths annually. Spalt-like transcription factor 4 is known as a transcription factor, which has an important role in the proliferation of cancerous cells. Small interfering RNA (siRNA) is a short-chain molecule of 20 to 25 nucleotides that protrude on two sides of the 3', two nucleotides. Read More
J Neurochem 2018 Dec 6. Epub 2018 Dec 6.
Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
The proportion of major depressive disorder (MDD) patients around the world has increased remarkably. Although many studies of MDD have been conducted based on classic hypotheses, like alteration of the hypothalamic-pituitary-adrenal axis or monoamine neurotransmitters, the mechanisms underlying MDD remain unclear. Aiming to further investigate the mechanisms of MDD, liquid-chromatography tandem mass spectrometry was employed to measure target metabolites in the hippocampus (HIPPO) of chronic social defeat stress (CSDS) model mice. Read More
J Cell Physiol 2018 Nov 22. Epub 2018 Nov 22.
Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
CD8 cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer. During cancer progression, CTLs encounter dysfunction and exhaustion due to immunerelated tolerance and immunosuppression within the tumor microenvironment (TME), with all favor adaptive immune-resistance. Cancer-associated fibroblasts (CAFs), macrophage type 2 (M2) cells, and regulatory T cells (Tregs) could make immunologic barriers against CD8 T cell-mediated antitumor immune responses. Read More
Br J Haematol 2018 Dec 5. Epub 2018 Dec 5.
Department of Haematology, Aarhus University Hospital, Aarhus, Denmark.
Targeted therapy directed against rare disease-propagating leukaemic stem cells (LSCs) is a promising prospect for improving the outcome of acute myeloid leukaemia (AML) patients. Thus, distinguishing LSCs from normal haematopoietic stem and progenitor cells (HSPCs) is essential. The CLEC12A receptor has been proposed as a specific marker of LSCs, and consequently as an appealing treatment target. Read More