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Clin Rheumatol 2020 Jul 8. Epub 2020 Jul 8.

Department of Rheumatology and Immunology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Background: Takayasu's arteritis (TA) may involve the pulmonary artery, which signifies a poor prognosis. This study investigated the features of TA patients with pulmonary artery involvement.

Methods: One hundred and twenty-six inpatients diagnosed with TA were retrospectively studied. Read More

J Thorac Dis 2020 May;12(5):2031-2038

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Background: The aim of this study was to investigate the risk factors of Takayasu arteritis (TA) involving the coronary artery.

Methods: Patients with TA involving coronary artery were included in this study. According to the patients' condition of coronary artery involvement, they were divided into two groups: group A: TA involved coronary artery disease [at least one coronary artery stenosis (≥50%)] and group B: TA did not involve coronary artery. Read More

Clin Exp Immunol 2020 Jul 8. Epub 2020 Jul 8.

Rheumatology Division, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil.

Takayasu arteritis (TAK) is a large-vessel granulomatous vasculitis, the inflammatory infiltration in arteries comprises macrophages, multinucleated giant cells, CD4 and CD8 T cells, γδ T cells, NK cells, and neutrophils. However, it is unknown which subtype of macrophages predominates. This study aims to evaluate macrophages subpopulations in the aorta in TAK. Read More

Cureus 2020 Jun 1;12(6):e8394. Epub 2020 Jun 1.

Neurology/Vascular Neurology, Cooper University Hospital, Camden, USA.

Takayasu arteritis (TA) is a rare inflammatory arteritis that is usually affecting young women and causes ischemic changes in the vessel wall. In this report of TA leading to an acute ischemic stroke, we describe a treatment-resistant case, with short interval flares and the challenge of defining the stroke etiology as a large vessel occlusive disease vs. an arteritis flare. Read More

Circulation 2020 Jul 6;142(1):92-94. Epub 2020 Jul 6.

Sorbonne Universités, Pitié-Salpêtrière University Hospital, Paris, France (Y.F., M.V., C.C., A.C.D., F.D., P.C., D.S.).

J Paediatr Child Health 2020 Jul 4. Epub 2020 Jul 4.

Faculty of Medicine, Department of Pediatric Cardiology, Eskisehir Osmangazi University, Eskisehir, Turkey.

Catheter Cardiovasc Interv 2020 Jul 4. Epub 2020 Jul 4.

Cardiology Clinical Academic Group, St George's Hospital, London, UK.

We describe the first long-term follow-up of a young patient with active Takayasu arteritis who presented with an acute coronary syndrome, treated endovascularly with percutaneous coronary intervention without stenting. A drug-coated balloon was used with high-resolution coronary imaging guidance in the form of optical coherence tomography on a critical ostial left anterior descending coronary artery lesion. A repeat procedure was undertaken after 4 months confirming a durable coronary angioplasty result and the patient remained symptom-free beyond 3 years. Read More

Clin Nucl Med 2020 Jun 25. Epub 2020 Jun 25.

Nuclear Medicine, Beijing Shijitan Hospital, Capital Medical University, Haidian District, Beijing, China.

Pulmonary artery involvement can occur in about half of the patients suffering Takayasu arteritis. Increased FDG activity in the aorta and its main branches in patients with Takayasu arteritis on PET/CT had been well-reported. However, the FDG PET/CT appearance of pulmonary artery involvement in Takayasu arteritis is less known. Read More

Int J Cardiol 2020 Jun 27. Epub 2020 Jun 27.

Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. Electronic address:

Ter Arkh 2020 Jun 5;92(5):85-91. Epub 2020 Jun 5.

Nasonova Research Institute of Rheumatology.

Takayasu arteritis (TA) is a systemic vasculitis with predominatly lesions of aorta and its large branches. In some cases pulmonary arteries (PA) are involved in the pathological inflammatory process and lead to the formation of pulmonary hypertension and significantly worse the prognosis. Timely development of lesion of PA, appointment of adequate therapy and surgical treatment can prevent irreversible damage of blood vessels and improve the prognosis. Read More

BMJ Case Rep 2020 Jun 28;13(6). Epub 2020 Jun 28.

Smt Kanuri Santhamma Center for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, India.

Rheumatology (Oxford) 2020 Jun 28. Epub 2020 Jun 28.

Chugai Pharmaceutical Co. Ltd, Tokyo, Japan.

Rheumatology (Oxford) 2020 Jun 28. Epub 2020 Jun 28.

Department of Rheumatology, Osaki Citizen Hospital, Osaki, Japan.

Ann Rheum Dis 2020 Jun 24. Epub 2020 Jun 24.

Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité Universitätsmedizin, Berlin, Germany

Ann Rheum Dis 2020 Jun 24. Epub 2020 Jun 24.

Internal Medicine, Tomakomai City Hospital, Tomakomai, Hokkaido 053-8567, Japan

Hipertens Riesgo Vasc 2020 Jun 18. Epub 2020 Jun 18.

Medicina Interna, Hospital Universitario Virgen de las Nieves, Granada, España.

Secondary arterial hypertension (HT) is an increase in blood pressure due to a recognisable cause. It is estimated that the prevalence of people with HT is around 5%-15%. The search for secondary HT in all hypertensive patients is neither feasible nor cost-effective. Read More

Clin Rheumatol 2020 Jun 19. Epub 2020 Jun 19.

Department of Hypertension, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, North Lishi Road, Xicheng District, Beijing, 100037, China.

Objective: The present study aimed to evaluate the value of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) aiding in diagnosing and evaluating disease activity in Takayasu arteritis (TA) patients with atypical clinical manifestations.

Methods: A retrospective study of 22 TA patients was conducted. All the participants were classified into two groups. Read More

J Clin Rheumatol 2020 Jun 17. Epub 2020 Jun 17.

From the Departments of Rheumatology and Allergy.

ESC Heart Fail 2020 Jun 19. Epub 2020 Jun 19.

Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Atypical aortic coarctation is a rare condition associated with Takayasu arteritis, and is characterized by symptoms caused either by hypotension in the lower half of the body or secondary hypertension in the upper half of the body, and heart failure. We report a rare case of axillofemoral bypass to improve congestive heart failure for atypical aortic coarctation complicating Takayasu arteritis. Augmented vascular bed and retrograde renal blood flow after axillofemoral bypass surgery could achieve effective blood pressure control and improve renal function and cardiac function (LVEF: 30% → 55%, BNP: 2943 pg/mL → 128 pg/mL). Read More

Clin Immunol 2020 Jun 12;217:108495. Epub 2020 Jun 12.

Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.

X-linked inhibitor of apoptosis protein (XIAP) deficiency results in monogenic inflammatory bowel disease. To date, no vasculitis associated with XIAP deficiency has been reported. A 10-year-old boy was diagnosed with Crohn's disease and he responded poorly to conventional treatment for Crohn's disease. Read More

Int J Rheum Dis 2020 Jun 15. Epub 2020 Jun 15.

Department of General Medicine, M.E.S. Medical College, Perinthalmanna, India.

Ther Adv Musculoskelet Dis 2020 2;12:1759720X20930114. Epub 2020 Jun 2.

Department of Rheumatology, Zhongshan Hospital, Fudan University, No 180 Fenglin Road Shanghai, 200032, P. R. China Centre of Evidence-based Medicine, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.

Background: Leflunomide (LEF) has been considered as an alternative treatment for Takayasu arteritis (TA); however, data on its efficacy are still scanty.

Objective: To investigate the efficacy and safety of LEF cyclophosphamide (CYC) for initial-onset TA.

Methods: Initial-onset TA patients with active disease were enrolled in this research. Read More

Ann Vasc Surg 2020 Jun 10. Epub 2020 Jun 10.

Department of Surgery, Section of Vascular Surgery and Endovascular Therapy, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.. Electronic address:

The Middle Aortic Syndrome (MAS) is an uncommon clinical expression as a result of isolated stenosis or complete occlusion of the descending thoracic and/or abdominal aorta; Takayasu's Arteritis (TA) is a rare vasculitis and a recognized etiology of MAS. We herein present the case of a 52 year old woman with refractory renovascular hypertension and progressive bilateral lower extremity claudication, she had known history of TA. A Computed Tomography Angiography (CTA) demonstrated an aortic occlusive lesion compromising the origin of the celiac trunk, superior mesenteric and bilateral renal arteries. Read More

Inflamm Regen 2020 2;40. Epub 2020 Jun 2.

Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.

Takayasu arteritis (TAK) affects the aorta and its primary branches, mainly in young women. In its advanced stages, it can cause severe complications, such as cerebral infarction, impaired vision, and valvular heart diseases. In the aortic tissue of TAK, there is increased infiltration of cytotoxic lymphocytes, such as natural killer (NK) cells and CD8T cells, and enhanced expression of accessory molecules, such as major histocompatibility complex (MHC) and MHC class I chain-related gene (MIC) family. Read More

Arthritis Res Ther 2020 06 5;22(1):131. Epub 2020 Jun 5.

Department of Rheumatology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.

Background: Takayasu arteritis (TA) is a large vessel vasculitis that can involve pulmonary arteries (PAs). We studied multiple clinical characteristics related to pulmonary artery involvement (PAI) in TA patients.

Methods: We enrolled 216 patients with TA from a large prospective cohort. Read More

Rheumatol Int 2020 Aug 4;40(8):1215-1221. Epub 2020 Jun 4.

Department of Academic Rheumatology, Liverpool University Hospitals, Liverpool, L9 7AL, UK.

Objective: To describe the prevalence of depression among patients with primary systemic vasculitides (PSV); compare prevalence according to vasculitis type and against controls; and examine the impact of depression on PSV outcomes.

Methods: We searched Medline, PubMed, Scopus and Web of Science using a predefined protocol in accordance with PRISMA guidelines. We included all studies that reported the prevalence or impact of depression in PSV. Read More

Arch Soc Esp Oftalmol 2020 May 31. Epub 2020 May 31.

Licenciado en Medicina y Cirugía. Servicio de Oftalmología, Hospital Universitario Virgen del Rocío de Sevilla, Sevilla, España; Hospital Universitario Virgen del Rocío. Oftalmología, sección de Retina Médica. Sevilla, Sevilla, España.

Ocular manifestations are observed in 25% of patients with Takayasu's arteritis. Its signs and symptoms can be very variable. The case is presented of a 41-year-old woman with progressive vision loss in her right eye secondary to ischaemic retinal arterial occlusion. Read More

BMC Cardiovasc Disord 2020 Jun 1;20(1):260. Epub 2020 Jun 1.

Department of Cardiovascular Medicine, Fukushima Medical University, 1 Hikarigaoka Fukushima, Fukushima, 960-1247, Japan.

Background: Isolated coronary Takayasu arteritis is a rare form of ischemic heart disease that typically appears as an aorto-ostial lesion. Although several vascular imaging modalities including ultrasonography, computed tomographic angiography, magnetic resonance angiography or catheter angiography, play crucial roles for diagnosing Takayasu arteritis, the intravascular ultrasound imaging of Takayasu arteritis is not well studied.

Case Presentation: A 55-year-old woman who was diagnosed with heterozygous familial hypercholesterolemia underwent coronary angiography due to effort angina, which showed ostial left anterior descending coronary artery (LAD) stenosis. Read More

J Rheumatol 2020 Jun 1. Epub 2020 Jun 1.

Département de Médecine Interne, Centre de Référence National pour les maladies auto-immunes systémiques rares, Hôpital Cochin, AP-HP; Département de Pharmacologie, Centre Régional de Pharmacovigilance, Hôpital Cochin, AP-HP; Département de Médecine Interne, Centre de Référence National pour les maladies auto-immunes systémiques rares, Hôpital Cochin, AP-HP, and Université Paris Descartes, Paris, France. Address correspondence to Prof. B. Terrier, Department of Internal Medicine, Hôpital Cochin, 27, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France. E-mail:

Aortitis is a rare inflammatory disease ranging from asymptomatic aortic thickening to life-threatening manifestations, especially aortic dissection or stenosis. Aortitis mainly occurs during systemic inflammatory diseases (giant cell arteritis, Takayasu arteritis, IgG4-related disease) and less frequently in patients with syphilis or tuberculosis Aortitis is rarely suspected to be induced by drugs and its causality is hardly assessable. The aim of our study is to identify drugs associated with aortitis occurrence using a data-mining approach. Read More

J Cardiol 2020 May 30. Epub 2020 May 30.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: No study has provided evidence of the clinical significance of the antineutrophil cytoplasmic antibody (ANCA) in patients with Takayasu arteritis (TAK). Therefore, we investigated the frequency of ANCA positivity and its clinical implications in patients with TAK.

Methods: We retrospectively reviewed the medical records of 121 patients with established TAK, who had results for ANCA status at diagnosis. Read More

West Afr J Med 2020 Jul-Aug;37(3):284-289

Rheumatology Unit, Department of Medicine, OAUTHC, Ile-Ife,Nigeria.

Takayasu's arteritis (TA) is an idiopathic form of large vessel granulomatous vasculitis that mainly affects the aorta and its major branches, most frequently in young women under 50 years. While traditionally, it is a disease found commonly in Asia continent, it has also been reported from different parts of the world, albeit with a few reports from Sub-Sahara Africa. The clinical presentations are variable and are commonly from systemic inflammation, vascular occlusive diseases and aneurysm. Read More

Radiol Clin North Am 2020 Jul;58(4):765-779

Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Hamburg 20251, Germany.

Vasculitides are a complex group of diseases sharing the defining feature of inflamed vessel walls. Vasculitides can be classified depending on the size of the predominantly affected vessels. Modern cross-sectional imaging methods have become a cornerstone in the diagnosis of vasculitis and may help in narrowing down differential diagnoses. Read More

Semin Arthritis Rheum 2020 May 14;50(4):586-591. Epub 2020 May 14.

Division of Rheumatology, Department of Internal Medicine, Marmara University, Turkey.

Objective: To assess the progression and the factors associated with damage in Takayasu's arteritis (TAK) patients during routine follow-up.

Methods: Patients diagnosed with TAK and had >6 months follow-up were enrolled in this study retrospectively. Takayasu's arteritis damage score (TADS) and vasculitis damage index (VDI) were determined at diagnosis and at the end of the follow-up and variables associated with damage scores were assessed. Read More

Circ Cardiovasc Imaging 2020 Jun 28;13(6):e010389. Epub 2020 May 28.

Vascular Sciences, National Heart and Lung Institute (J.M.T., J.C.M.), Imperial College London, United Kingdom.

Semin Arthritis Rheum 2020 May 19;50(4):576-581. Epub 2020 May 19.

Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD, USA.

Objective: Takayasu's arteritis (TAK) is a clinically heterogenous disease. Patterns of clinical presentation in TAK at diagnosis have not been well described, and a "triphasic pattern" of constitutional symptoms evolving into vascular inflammation and fibrosis has been reported but never systematically evaluated.

Methods: Patients with TAK were prospectively recruited from the National Institutes of Health (NIH) and the Vasculitis Clinical Research Consortium (VCRC). Read More

Orv Hetil 2020 06;161(23):939-950

Angiológia,Szent Imre Egyetemi Oktatókórház Budapest, Tétényi út 12-16., 1115.

According to the nomenclature of the Chapel Hill Consensus Conference, giant-cell arteritis and Takayasu's arteritis belong to the group of large-vessel vasculitis. Recognition of these diseases is primarily based on the clinical assessment and the use of various vascular imaging modalities. With regard to the latter one, significant technological advances have been observed in recent years, which allow not only to make a diagnosis but also to evaluate the extent of the disease and the degree of vascular inflammation. Read More

J Clin Rheumatol 2020 May 21. Epub 2020 May 21.

From the Department of Clinical Immunology andRheumatology, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, Odisha, India.

J Clin Rheumatol 2020 May 21. Epub 2020 May 21.

Rheumatology Unit Western General Hospital, Edinburgh United Kingdom Rheumatology Unit Western General Hospital Edinburgh UK and Centre for Genomics and Experimental Medicine Institute of Genetics and Molecular Medicine University of Edinburgh Edinburgh, United Kingdom

Arch Gynecol Obstet 2020 Jul 21;302(1):281-282. Epub 2020 May 21.

Department of Cardiology and Intensive Care, St. Josef Hospital Braunau, Ringstrasse 60, 5280, Braunau, Austria.

Gen Thorac Cardiovasc Surg 2020 May 19. Epub 2020 May 19.

Department of Clinical Laboratory, The First Hospital of Putian, Teaching Hospital, Fujian Medical University, 389 Longdejing Street, Chengxiang District, Putian, 351100, Fujian, People's Republic of China.

Coronary artery involvements in patients with Takayasu arteritis (TA) have not been sufficiently described. By comprehensive retrieval of the pertinent literature published in the past two decades, 59 reports including 141 patients were recruited into this study. In TA patients with coronary artery involvements, the right coronary artery was the most commonly affected. Read More

Z Rheumatol 2020 May 19. Epub 2020 May 19.

Klinik für Rheumatologie und klinische Immunologie, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Large vessel vasculitides comprise two distinct entities, giant cell arteritis (GCA) and Takayasu arteritis (TAK). GCA is the most common vasculitis in central Europe, becoming manifested at an age over 50 years. In contrast, the much rarer TAK affects almost exclusively young adults and mostly women. Read More

Z Rheumatol 2020 May 19. Epub 2020 May 19.

Vaskulitiszentrum Süd, Klinik für Innere Medizin, Rheumatologie und Immunologie, Medius Kliniken - Akademisches Lehrkrankenhaus der Universität Tübingen, Eugenstr. 3, 73230, Kirchheim u. Teck, Deutschland.

Despite advances in the diagnosis and treatment, the mortality rate of Takayasu arteritis (TAK) is still elevated even today. The diagnosis is often made after a long time delay and the course of the disease is characterized by progressive structural vascular lesions. Recently, new recommendations for the management of large vessel vasculitis were published by the European League Against Rheumatism (EULAR). Read More

Clin Rheumatol 2020 May 18. Epub 2020 May 18.

Department of Rheumatology, Capital Medical University Affiliated Anzhen Hospital, 2 Anzhen Road, Chaoyang District, Beijing, China.

Objectives: Takayasu arteritis (TA) is a rare granulomatous vasculitis. Numano type V was the most frequently involved arteritis in China. In our study, we aimed to investigate the characteristics of the type V TA in Chinese people. Read More

Can J Cardiol 2020 Jun 28;36(6):969.e11. Epub 2020 Feb 28.

Cardiovasc Intervent Radiol 2020 May 10. Epub 2020 May 10.

Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, 110029, India.

Aortitis includes conditions with infectious or non-infectious etiology, characterized by inflammatory changes in one or more layers in aortic wall. Age at onset, geographic predilections, distribution and pattern of involvement in aorta, its branches and pulmonary arteries, and systemic associations provide a clue to etiology. Clinical presentations are often non-specific. Read More

Clin Rheumatol 2020 May 9. Epub 2020 May 9.

Department of Rheumatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.

Objective: To evaluate the value of interleukin-6 (IL-6) in predicting long-term disease prognosis for Takayasu arteritis (TA).

Methods: Sixty-seven TA patients, who had IL-6 levels detected at the first visit and had a regular follow-up of at least 2 years, were enrolled. Data recorded up to March 31, 2019, including clinical presentations, laboratory indices, treatments, and radiological images were collected and used for analysis. Read More

Ann Rheum Dis 2020 May 7. Epub 2020 May 7.

Internal Medicine, Tomakomai City Hospital, Tomakomai, Hokkaido, Japan

Ann Thorac Surg 2020 May 3. Epub 2020 May 3.

Department of Cardiovascular Surgery, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.

Takayasu arteritis (TA) occasionally involves the coronary ostium leading to myocardial ischemia. Although surgical coronary ostial angioplasty is desirable for the ostial stenosis, the patch materials and long-term results are controversial. We have used femoral artery (FA) as a patch material for coronary ostial angioplasty in three TA patients. Read More

J Rheumatol 2020 May 1. Epub 2020 May 1.

Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China; Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, P. R. China; Center of Evidence-based Medicine, Fudan University, Shanghai, P. R. China. Address correspondence to Lindi Jiang, PhD, MD, 180 Fenglin Road, Department of Rheumatology, Zhongshan Hospital, Fudan, University, Shanghai 200032, P. R. China. E-mail:

Objective: To investigate the characteristics of patients with Takayasu arteritis (TA)- related renal artery stenosis and identify the predictors of medium-term adverse outcomes.

Methods: Data for 567 patients registered in a large prospective observational cohortthe East China Takayasu arteritis cohort-up to April 30, 2019, were retrospectively analyzed.

Results: Renal artery stenosis was confirmed in 172/567 (30. Read More

Eur Heart J Case Rep 2020 Apr 17;4(2):1-6. Epub 2020 Feb 17.

Division of Cardiology, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama 232-0024, Japan.

Background: The present article describes two cases of patients with coronary arteritis (CA) whose identification of CA diagnosis (late vs. early) resulted in different clinical courses and outcomes.

Case Summary: Case 1 is a 53-year-old woman with multiple coronary risk factors who was admitted with acute coronary syndrome (ACS) and significant stenosis in the left main trunk (LMT). Read More