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Interact Cardiovasc Thorac Surg 2022 Jun 24. Epub 2022 Jun 24.

Department of Cardiovascular Surgery, Nagoya City University Graduate School of Medical Sciences.

Takayasu arteritis (TA) results in a variety of vascular symptoms, and there are some cases in which progressive vascular lesions require surgical intervention. We present a case with ascending aortic aneurysm, right common carotid artery stenosis, left common carotid artery occlusion, and left subclavian artery stenosis caused by TA that was successfully treated with total arch replacement and ascending aorta to right internal carotid artery bypass. Read More

Blood Press 2022 Dec;31(1):146-154

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Takayasu arteritis (TA) is a rare disease, which is frequently misdiagnosed or its diagnosis can be missed. This study aimed to analyse the characteristics of four-limb blood pressure (4LBP) and brachial-ankle pulse wave velocity (baPWV) in patients with TA, which could be useful in disease detection. We consecutively enrolled 182 patients with TA at Fuwai Hospital between January 2013 and January 2016. Read More

J Endovasc Ther 2022 Jun 23:15266028221105180. Epub 2022 Jun 23.

Internal Medicine Residency, Freeman Health System, Joplin, MO, USA.

Purpose: Takayasu arteritis is a large-vessel vasculitis in women of childbearing age that affects large vessels including the aorta and its main branches. Inflammation of arteries can produce lesions that lead to occlusion, stenosis, or aneurysms which can lead to complications. If signs of organ dysfunction are present, vascular intervention may be necessary. Read More

Expert Rev Clin Immunol 2022 Jun 17. Epub 2022 Jun 17.

Rheumatology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Introduction: Giant cell arteritis (GCA) and Takayasu arteritis (TAK) are the major forms of large vessel vasculitis (LVV).Glucocorticoids represent the cornerstone of LVV treatment, however, relapses and recurrences frequently occur when they are tapered or stopped, determining a prolonged exposure to glucocorticoids and a subsequent increased risk of glucocorticoid-related side effects. Therefore, conventional and biologic immunosuppressive drugs have been proposed to obtain a glucocorticoid-sparing effect. Read More

J Rheumatol 2022 Jun 15. Epub 2022 Jun 15.

Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, No. 127 Changle West Rd., Xi'an, 710032, Shaanxi, China; Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, No. 127 Changle West Rd., Xi'an, 710032, Shaanxi, China. Jin Ding and Dangjie Wu contributed equally to this work. Funding: This study has received funding from Xijing Zhutui Project (XJZT19ML55) and the National Natural Science Foundation of China (Grant No: 81871273). Conflicts of interest: All authors declare no conflicts of interest. Corresponding author: Zhaohui Zheng, Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, No. 127 Changle West Rd., Xi'an, 710032, Shaanxi, China. Ping Zhu, Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, No. 127 Changle West Rd., Xi'an, 710032, Shaanxi, China.

Objective: The literature describing follow-up carotid contrast-enhanced ultrasonography (CEUS) is limited. We report our experience with monitoring CEUS performed in patients with Takayasu arteritis (TAK).

Methods: We retrospectively analyzed patients with TAK who had undergone carotid CEUS ≥2 times with a follow-up duration ≥12 months at Xijing Hospital between 2017 and 2020. Read More

Pol Arch Intern Med 2022 Jun 6. Epub 2022 Jun 6.

Large vessel vasculitis (LVV), including Takayasu arteritis (TAK) and giant cell arteritis (GCA), causes granulomatous vascular inflammation mainly in large vessels, and is the most common primary vasculitis in adults. Vascular inflammation may evoke many clinical features including vision impairment, stroke, limb ischemia, and aortic aneurysms. The best way to diagnose LVV is to combine medical history, physical examination, various laboratory tests, and imaging modalities. Read More

Gen Thorac Cardiovasc Surg 2022 Jun 12. Epub 2022 Jun 12.

Department of Cardiovascular Surgery, Sakakibara Heart Institute, 3-16-1, Asahi-cho, Fuchu-shi, Tokyo, 183-0003, Japan.

Takayasu arteritis can affect the coronary ostia, leading to myocardial ischemia. Coronary ostial angioplasty effectively treats coronary artery ostial lesions associated with Takayasu arteritis. We present a case of juvenile Takayasu arteritis with bilateral subclavian artery occlusions treated with a novel coronary artery ostial angioplasty using the external iliac artery. Read More

Intern Med 2022 Jun 7. Epub 2022 Jun 7.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.

Front Med (Lausanne) 2022 16;9:863150. Epub 2022 May 16.

Department of Biomedical Sciences and Human Oncology, Pharmacology Section, University of Bari Aldo Moro Medical School, Bari, Italy.

Background: Takayasu Arteritis (TAK) increases vascular stiffness and arterial resistance. Atherosclerosis leads to similar changes. We investigated possible differences in cardiovascular remodeling between these diseases and whether the differences are correlated with immune cell expression. Read More

Front Med (Lausanne) 2022 12;9:824630. Epub 2022 May 12.

Internal Medicine Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Chronic inflammation represents the cornerstone of the raised cardiovascular (CV) risk in patients with inflammatory rheumatic diseases (IRD), including vasculitis. Standardized mortality ratios in these patients are higher as compared to the general population, and the excess of premature mortality is due to early atherosclerotic events. Thus, IRD patients need appropriate CV risk assessment and management according to this CV disease (CVD) burden. Read More

JNMA J Nepal Med Assoc 2022 Apr 15;60(248):393-395. Epub 2022 Apr 15.

Department of Internal Medicine, Nepal Medical College Teaching Hospital, Attarkhel, Kathmandu, Nepal.

Takayasu arteritis is a rare progressive chronic granular inflammation of the vessels that mainly affects the aorta and its branches. It is widely distributed in the world population and mainly involves young Asian women, manifesting as a systemic illness with myriads of cardiovascular signs and symptoms. The current case focuses on a young girl who had shoulder pain and weakness as the only manifestation of underlying Takayasu arteritis. Read More

Eur Heart J Cardiovasc Imaging 2022 May 25. Epub 2022 May 25.

Department of Radiology, Tokyo Women's Medical University Adachi Medical Center, 4-33-1 Kohoku, Adachi, Tokyo 123-8558, Japan.

Int J Rheum Dis 2022 May 23. Epub 2022 May 23.

Koc University School of Medicine, Rheumatology, Istanbul, Turkey.

Objective: Metabolic syndrome (MetS) is one of the preventable risk factors for cardiovascular disease (CVD). The aim of this study was to investigate the effect of MetS on CVD and cumulative organ damage in a multi-center, large cohort of patients with Takayasu arteritis (TAK).

Methods: This is a cross-sectional study involving 192 consecutive TAK patients from seven tertiary rheumatology centers in Turkey. Read More

Saudi J Ophthalmol 2021 Jul-Sep;35(3):198-203. Epub 2022 Apr 18.

Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA.

There are multiple vasculitides which are distinguished based on multiple criteria, including size of affected vessels, distribution of vessels affected, histopathologic differences, genetic factors, and age at presentation. Takayasu's arteritis (TkA) and giant cell arteritis (GCA) are the two main medium to large vessel vasculitides. These vasculitides are associated with different racial predilections, vascular distributions, age groups, diagnostic criteria, and treatments. Read More

Respirol Case Rep 2022 Jun 18;10(6):e0976. Epub 2022 May 18.

Department of Respiratory Medicine Tokyo Medical University Hospital Tokyo Japan.

The double-ring sign found in contrast-enhanced computed tomography, which reflects inflammatory changes in the adventitia and oedema of the intima, is thought to be characteristic of Takayasu arteritis; however, herein, it was also observed for granulocyte colony-stimulating factor-induced vasculitis. Read More

Egypt Heart J 2022 May 21;74(1):41. Epub 2022 May 21.

Faculty of Medicine, University of Jember, Jl. Kalimantan No. 37, Jember, East Java, 68121, Indonesia.

Background: Takayasu arteritis (TA) is included in large vessel vasculitis with unknown aetiopathogenesis. TA is one of the rare diseases with a predilection for young women. The diagnosis of TA is difficult due to variation in clinical presentations and non-specific initial symptoms. Read More

Front Psychiatry 2022 2;13:882870. Epub 2022 May 2.

Centro Cardiologico Monzino, IRCCs, Milan, Italy.

Introduction: Takayasu's arteritis (TA) is a systemic inflammatory disease that affects aorta and its major branches. There are several cardiac manifestations of TA and an association with Takotsubo syndrome (TTS) - but not coronary vasospasm - has been previously reported. The role of emotional stress in this context is unknown. Read More

Am J Case Rep 2022 May 19;23:e936321. Epub 2022 May 19.

Department of Neurology, National Neuroscience Institute, Singapore, Singapore.

BACKGROUND Takayasu arteritis is a rare systemic inflammatory vasculitis of granulomatous nature. The etiology of Takayasu arteritis is still unknown and it affects the aorta and its main branches. Takayasu arteritis is more common in Asians and women of childbearing age. Read More

Ocul Immunol Inflamm 2022 May 18:1-10. Epub 2022 May 18.

Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro," Medical School, Bari, Italy.

Purpose: We describe ophthalmic manifestations, therapy, and outcomes in 16 patients with Takayasu arteritis (TA).

Methods: Takayasu retinopathy was detected in 15 eyes of 9 patients and hypertensive retinopathy in 14 eyes of 7 patients.

Results: Visual acuity was normal in 7 eyes, 20/40 to 20/200 in 20 eyes, counting fingers in 2 eyes, hand motion in 2 eyes, and no light perception in 1 eye. Read More

Ther Umsch 2022 Jun;79(5):221-228

Universitätsklinik für Rheumatologie und Immunologie, Inselspital Bern.

Large Vessel Vasculitides: Giant Cell Arteritis and Takayasu Arteritis - Similarities and Differences According to the Chapel Hill Consensus Conference Nomenclature of 2012, giant cell arteritis (GCA) and Takayasu arteritis (TAK) belong to the idiopathic large vessel vasculitides. While GCA is a typical disease of the elderly, TAK begins in adolescence and young adulthood, sometimes even in childhood. In both diseases, immune-mediated granulomatous vascular wall inflammation of the aorta and its major branches leads to the formation of stenoses, occlusions, and aneurysms. Read More

Semin Arthritis Rheum 2022 Apr 28;55:152016. Epub 2022 Apr 28.

Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. Electronic address:

Objectives: To investigate the pregnancy outcomes of patients with Takayasu arteritis (TAK) and identify the relevant risk factors.

Methods: A total of 110 pregnancies in 80 patients in a Chinese TAK cohort and 550 matched pregnancies in healthy women between 2000 and 2020 were included. The pregnancy outcomes between patients and controls were compared by Fisher's exact test. Read More

Eur J Cardiothorac Surg 2022 May 12. Epub 2022 May 12.

Division of Congenital Cardiovascular Surgery, Paediatric Heart Centre, Children's Research Centre, University Children's Hospital, University of Zurich, Switzerland.

Objectives: Timing and method of surgical reconstruction for non-sclerotic proximal coronary artery stenosis, occuring de-novo or post coronary artery transfer, are evolving. We have pursued a technique of anatomical reconstruction of ostial and short segment proximal coronary artery stenosis and atresia in children, using patch plasty or interposition vein graft. Herein, we discuss the medium- to long-term outcome. Read More

Clin Rheumatol 2022 May 11. Epub 2022 May 11.

Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow-226014, India.

It is now well established that Th17 lymphocytes associate with myriad immune-mediated inflammatory diseases. Over the past one and a half decades, a subset of Th17 lymphocytes viz. Th17. Read More

Asia Pac J Ophthalmol (Phila) 2022 Mar-Apr 01;11(2):177-183

Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, US.

Abstract: Giant cell arteritis and Takayasu arteritis are large-vessel vasculitides that share multiple common features but also have significant differences in epidemiology, demographics, clinical presentation, evaluation, and treatment. Giant cell arteritis is more common in elderly patients of Caucasian descent versus Takayasu arteritis, which is more prevalent in younger patients of Asian descent. Although traditionally age has been the main criterion for differentiating the 2 etiologies, modifications in the diagnostic criteria have recognized the overlap between the 2 conditions. Read More

Arthritis Res Ther 2022 05 7;24(1):102. Epub 2022 May 7.

Department of Rheumatology and Immunology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing, 100029, China.

Objective: Aortic valve involvement is not uncommon in patients with Takayasu arteritis (TAK) and leading to poor prognosis. The aim of our study was to explore the risk factors of aortic valve involvement and to evaluate the prognosis in TAK patients with aortic valve involvement.

Method: In this retrospective study, 172 TAK patients were divided into groups with or without aortic valve involvement to identify the risk factors. Read More

Semin Arthritis Rheum 2022 Apr 29;55:152018. Epub 2022 Apr 29.

Department of Rheumatology, Zhongshan Hospital affiliated to Fudan University, Shanghai, China. Electronic address:

To investigate the efficacy and safety of leflunomide (LEF) versus tofacitinib (TOF) in Takayasu arteritis (TAK) patients. Sixty-seven active patients were recruited from an ongoing observational TAK cohort, including 35 patients treated with glucocorticoids (GCs) and LEF and 32 patients treated with GCs and TOF. The observation period was 12 months. Read More

Pediatr Int 2022 01;64(1):e15187

Department of Pediatrics, National Hospital Organization Shimoshizu National Hospital, Yotukaido City, Japan.

Front Pediatr 2022 13;10:872313. Epub 2022 Apr 13.

Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.

Takayasu Arteritis (TAK) is a rare large vessel vasculitis affecting the aorta and its major branches. The heterogeneous and often severe clinical manifestations result from systemic and local inflammation as well as end-organ ischemia. Disease flares are common and contribute to accrued damage over time with significant morbidity and mortality. Read More

Front Cardiovasc Med 2022 12;9:874242. Epub 2022 Apr 12.

Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States.

Aortic insufficiency is commonly observed in rheumatologic diseases such as ankylosing spondylitis, systemic lupus erythematosus, antiphospholipid syndrome, Behçet's disease, granulomatosis with polyangiitis, and Takayasu arteritis. Aortic insufficiency with an underlying rheumatologic disease may be caused by a primary valve pathology (leaflet destruction, prolapse or restriction), annular dilatation due to associated aortitis or a combination of both. Early recognition of characteristic valve and aorta morphology on cardiac imaging has both diagnostic and prognostic importance. Read More

Zhonghua Nei Ke Za Zhi 2022 May;61(5):517-524

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China.

Takayasu's arteritis (TAK) mainly involves the aorta and its major branches, which is characterized as a chronic, progressive and inflammatory disease. China belongs to one of the regions with a high prevalence of TAK referring to its global distribution. However, it is insufficient for the spread and update of standardized diagnosis and treatment of TAK. Read More