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Rheumatology (Oxford) 2021 Jun 22. Epub 2021 Jun 22.

Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.

Objective: To investigate the utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in assessing disease activity in Takayasu arteritis (TA).

Methods: Ninety-one patients with TA, were recruited from a Chinese cohort. Clinical data, acute-phase reactants (APRs), and 18F-FDG-PET/CT findings were simultaneously recorded. Read More

Front Cardiovasc Med 2021 4;8:683216. Epub 2021 Jun 4.

Department of Cardiovascular Surgery, Sapporo, Japan.

Takayasu arteritis (TA) is a large vessel vasculitis of unknown etiology characterized by chronic inflammatory changes of the aorta and its major branches. Complications such as anastomotic aneurysm and valve detachment have been reported in active TA patients who received aortic valve replacement and graft replacement of aorta. A 61-year-old man with a history of emergency aortic valve replacement and patch closure of the noncoronary sinus of Valsalva due to acute heart failure induced by acute aortic regurgitation and ruptured sinus of Valsalva 4 years ago was referred for exertional dyspnea. Read More

Semin Arthritis Rheum 2021 Jun 7;51(4):786-792. Epub 2021 Jun 7.

Rheumatology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy; Università di Modena e Reggio Emilia, Modena, Italy. Electronic address:

Objectives: To investigate the epidemiology of the entire spectrum of large vessel vasculitis (LVV) in a well-defined population from a Northern Italian area.

Methods: All patients with incident giant cell arteritis (GCA) diagnosed from 2005 to 2016 and all patients with incident Takayasu arteritis (TAK) diagnosed from 1998 to 2016 living in the Reggio Emilia area were identified. Only patients satisfying the modified inclusion criteria of the GiACTA trial, and the 1990 ACR classification criteria for TAK were included. Read More

PLoS One 2021 18;16(6):e0250025. Epub 2021 Jun 18.

Department of Rheumatology, Immunology and Allergology, University Hospital (Inselspital) and, University of Bern, Bern, Switzerland.

Objective: Takayasu arteritis (TAK) is a rare immune-mediated vasculitis of the aorta and its branches. Aims were to calculate prevalence and incidence in Switzerland, to assess disease activity and performance of MR-Angiography (MRA).

Methods: 31 patients were recorded in a database, 27 were followed prospectively up to 3 years. Read More

Rheumatology (Oxford) 2021 Jun;60(Supplement_3):iii6-iii8

Rheumatology Department, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London W12 OHS, UK.

Int J Rheum Dis 2021 Jun 16. Epub 2021 Jun 16.

Department of Rheumatology, Shimane University Faculty of Medicine, Shimane, Japan.

Circ Rep 2021 May 20;3(6):354-355. Epub 2021 May 20.

Third Department of Internal Medicine, Obihiro-Kosei Hospital Obihiro Japan.

Case Rep Pediatr 2021 27;2021:8885944. Epub 2021 May 27.

Gandhi Medical College and Hospital, Secunderabad 500003, India.

Takayasu arteritis is a systemic vasculitis of large vessels that mainly involves the aorta and its branches. It normally presents in the third decade of life and is rarely seen in children. We report a case of childhood Takayasu arteritis, in a 12-year-old girl, who presented with abdominal pain and hypertension. Read More

Rev Med Interne 2021 Jun 11. Epub 2021 Jun 11.

Department of Internal Medicine, CHRU Tours, Tours; Université de Tours. Electronic address:

Open Access Rheumatol 2021 1;13:153-165. Epub 2021 Jun 1.

Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium.

The large vessel vasculitides comprise giant cell arteritis (GCA), Takayasu arteritis (TAK), and chronic periaortitis. The diagnostic approach to these conditions involves the correct use and interpretation of clinical criteria, imaging techniques, and, in case of GCA, temporal artery biopsy. Ultrasound, magnetic resonance imaging (MRI), and computed tomography (CT) reveal a homogeneous, concentric, thickening of the arterial wall. Read More

Acta Radiol 2021 Jun 9:2841851211019806. Epub 2021 Jun 9.

Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.

Renal arteries are involved in a wide spectrum of pathologies including atherosclerosis, fibromuscular dysplasia, Takayasu arteritis, aneurysms, and aortic type B dissections extending into main renal arteries. They manifest as renovascular hypertension, renal ischemia, and cardiovascular dysfunction. The location of the renal arteries in relation to the abdominal aortic aneurysm is a critical determinant of interventional options and long-term prognosis. Read More

J Anaesthesiol Clin Pharmacol 2021 Jan-Mar;37(1):136-137. Epub 2021 Apr 10.

Department of Orthopaedics, Command Hospital, Chandigarh, Punjab, India.

Rheumatol Int 2021 Jun 6. Epub 2021 Jun 6.

Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.

Takayasu arteritis (TA) is a large-cell vasculitis, and is not usually associated with avascular necrosis (AVN). The objective of the study was to investigate any association between TA and AVN, including the possible pathogenic effect of glucocorticoid (GCs) use. The study design was retrospective and cross sectional. Read More

J Nucl Med 2021 Jun 4. Epub 2021 Jun 4.

National Institute of Arthritis and Musculoskeletal and Skin Diseases, United States.

The study rationale was to assess the performance of qualitative and semi-quantitative scoring methods for F-fluorodeoxyglucose positron emission tomography (FDG-PET) assessment in large-vessel vasculitis (LVV). Patients with giant cell arteritis (GCA) or Takayasu's arteritis (TAK) underwent clinical and imaging assessment, blinded to each other, within a prospective observational cohort. FDG-PET-CT scans were interpreted for active vasculitis by central reader assessment. Read More

J Cardiovasc Imaging 2021 Apr 15. Epub 2021 Apr 15.

Division of Rheumatology, Department of Internal Medicine, Research Institute of Medical Science, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

Front Immunol 2021 17;12:646516. Epub 2021 May 17.

Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China.

Objectives: To investigate vascular macrophage phenotype as well as vascular and peripheral chemokine (C-C motif) ligand 2 (CCL2) expression during different stages of disease progression in patients with Takayasu Arteritis (TA).

Methods: In this study, 74 patients with TA and 50 controls were recruited. TA disease activity was evaluated with Kerr scores. Read More

Front Cardiovasc Med 2021 12;8:603354. Epub 2021 May 12.

Department of Clinical Immunology, Xijing Hospital, Air Force Medical University (Fourth Military Medical University), Xi'an, China.

Takayasu arteritis (TA) is a kind of large-vessel vasculitis that mainly affects the aorta and its branches, and the patients are usually women at a relatively young age. The chronic inflammation of arteries in TA patients leads to stenosis, occlusion, dilatation, or aneurysm formation. Patients with TA thereby have a high risk of cardiovascular disease (CVD) complications, which are the most common cause of mortality. Read More

Arch Rheumatol 2021 Mar 25;36(1):138-139. Epub 2020 Jun 25.

Department of Obstetrics and Gynecology, University of Bari Aldo Moro, Bari, Italy.

Arthritis Rheumatol 2021 May 27. Epub 2021 May 27.

Institute of Clinical Sciences, Centre for Translational Inflammation Research, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB.

Due to the relatively small number of outcomes in our study, we decided that it was best to be conservative in the number of covariates we included in the Cox regression models. We therefore restricted to age, sex, BMI, Townsend deprivation quintile and smoking status. We provided information on statin use, steroid use and comorbidities in the exposed and unexposed groups in the baseline table. Read More

Arthritis Rheumatol 2021 May 27. Epub 2021 May 27.

Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan.

We read with great interest the paper by Goel et al about cardiovascular disease in Takayasu arteritis (TAK) (1). They conducted an open retrospective matched cohort study to estimate risk of comorbidities in TAK. They then find out that Cardiovascular morbidity was increased among patients with TAK. Read More

BMJ Case Rep 2021 May 26;14(5). Epub 2021 May 26.

Obstetrics and Gynaecology, JIPMER, Puducherry, Tamil Nadu, India.

A young pregnant woman, G2P1L1, was admitted for safe confinement at 40 weeks of gestation with Takayasu arteritis. She was diagnosed with Takayasu arteritis in 2016 when she had polyarthritis, hypertension and asymmetrical peripheral pulses. Her CT angiogram showed involvement of branches of aortic arch and coeliac trunk. Read More

Cardiovasc Pathol 2021 May 24:107347. Epub 2021 May 24.

Department of Pathology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

This is a rare presentation of Takayasu arteritis in a 30-year-old Canadian First Nations woman with cardiac and aortic root-predominant disease, which manifested in complete heart block. She had a past medical history significant for substance misuse. At presentation, cardiac magnetic resonance imaging identified diffuse thickening of the left atrium and ventricular outflow tract with left ventricular cavity dilation and preserved systolic function. Read More

Clin Nucl Med 2021 May 12. Epub 2021 May 12.

From the Departments of Nuclear Medicine and Minnan PET Center Radiation Oncology, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, China.

Abstract: Evaluation of disease activity in Takayasu arteritis (TA) is challenging because clinical, biological, and imaging data do not always correlate. In this case, a 19-year-old woman with TA underwent 18F-FDG PET/CT for evaluating disease activity. However, no abnormal 18F-FDG uptake was observed in the large arteries. Read More

Arch Med Sci Atheroscler Dis 2021 16;6:e79-e84. Epub 2021 Apr 16.

Division of Community and Family Medicine, Jichi Medical University, Shimotsuke-city, Japan.

Introduction: Takayasu arteritis (TA) is a chronic vasculitis associated with an increased cardiovascular risk. The measurement of pulse wave velocity (PWV), carotid artery intima-media thickness (CIMT) and flow-mediated dilatation (FMD) are generally used for evaluating the cardiovascular risk. The application of these measurements to TA patients remains undetermined. Read More

HeartRhythm Case Rep 2021 May 14;7(5):261-266. Epub 2021 May 14.

Department of Cardiology, Evangelisches Krankenhaus Kalk, Cologne, Germany.

Cureus 2021 Apr 19;13(4):e14557. Epub 2021 Apr 19.

Internal Medicine, Army Medical College, Rawalpindi, PAK.

Takayasu's arteritis (TA), commonly referred to as "pulseless" disease, is a large-vessel inflammatory vasculitis most commonly affecting the aorta and its major branches. Due to its irregular nature, it has the propensity to involve any organ system thus leading to a wide spectrum of clinical features. Most patients affected by TA are females in their second or third decades of lives. Read More

Clin Rheumatol 2021 May 22. Epub 2021 May 22.

Department of Rheumatology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.

Objectives: We aimed to construct and validate a risk assessment model to identify risk factors for heart failure (HF) in patients with Takayasu's arteritis (TAK).

Methods: Three hundred sixty-five patients with TAK were recruited in the East China Takayasu Arteritis Cohort from January 2012 to December 2019. Patients were assigned into training and validation sets following a 2:1 ratio according to the date of enrollment. Read More

Cardiol Young 2021 May 21:1-4. Epub 2021 May 21.

Congenital Heart Center, Department of Paediatrics, University of Florida, Gainesville, FL, USA.

This series describes three adolescent females who presented with chest pain and ventricular dysfunction related to acute coronary ischemia secondary to Takayasu's arteritis with varied courses of disease progression leading to a diverse range of therapies including cardiac transplantation. While Takayasu's arteritis is rare in childhood, it should be strongly considered in any adolescent female presenting with systemic inflammation and chest pain consistent with myocardial infarction. A high index of suspicion can lead to early detection and aggressive management of the underlying vasculitis reducing associated morbidity and mortality. Read More

Clin Exp Rheumatol 2021 Mar-Apr;39 Suppl 129(2):161-170. Epub 2021 May 19.

Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, and Evidence-Based Medicine Centre, Fudan University, Shanghai, China.

Objectives: Takayasu's arteritis (TAK) is a chronic inflammatory disease with several challenges in treatment. Curcumin is known for its anti-inflammatory effects, whereas its effect in the treatment of TAK remains unclear. In this study, we aimed to investigate the effect of curcumin in the treatment of TAK and its underlying mechanisms. Read More

Front Immunol 2021 30;12:630619. Epub 2021 Apr 30.

Department of Neurology, Center for Mental and Neurological Disorders and Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Takayasu arteritis (TA) is a chronic inflammatory disease involving the aorta and its principal branches. Acute ischaemic stroke (AIS) as the initial manifestation of TA is uncommon. There is little evidence on the efficacy of bridging therapy for AIS induced by TA. Read More