460,098 results match your criteria Systemic Sclerosis


Evaluation of Genotoxicity of Nanoparticles in Mouse Models.

Methods Mol Biol 2019 ;1894:301-312

Cancer Research Center, University at Albany, State University of New York, Rensselaer, NY, USA.

Owing to new and unique properties, engineered nanoparticles (NPs) likely pose different risks than their constituent chemicals and these risks need to be understood. In particular, it is important to assess genotoxicity, since genotoxicity is a precursor to carcinogenicity. Here we describe a battery of tests for the assessment of genotoxicity of NPs in vivo in mice. Read More

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January 2019

Systemic Rapamycin Attenuates Morphine-Induced Analgesic Tolerance and Hyperalgesia in Mice.

Neurochem Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiovasology, Tianjin Union Medical Center, 190 Jieyuan St., Hongqiao District, Tianjin, 300121, China.

Previous studies showed that repeated intrathecal morphine injection activated the mammalian target of rapamycin complex 1 (mTORC1) in spinal dorsal horn neurons and that blocking this activation by intrathecal infusion of rapamycin, a specific mTORC1 inhibitor, prevented the initiation of morphine-induced tolerance and hyperalgesia. However, in clinic, rapamycin is usually administrated orally. In this study, we examined whether systemic administration of rapamycin had the effect on morphine-induced tolerance and hyperalgesia in mice. Read More

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December 2018

The Interaction of Race and Gender as a Significant Driver of Racial Arrest Disparities for African American Men.

J Urban Health 2018 Dec 13. Epub 2018 Dec 13.

San Diego School of Medicine, Center on Gender Equity and Health, University of California, San Diego, La Jolla, CA, USA.

The mass incarceration of African Americans is both a driver of racial health inequalities in the USA. Systemic social biases which associate African American men with criminality, violence, and as a particular threat to white women may partially explain their over-representation in the criminal justice system. We combined data from the Washington, DC Metro Police Department (MPD) and the American Community Survey to test whether neighborhood-level gender, race, and economic makeup were associated with elevated drug-related arrest disproportions for African American men. Read More

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December 2018

Low serum folic acid can be a potential independent risk factor for erectile dysfunction: a prospective case-control study.

Int Urol Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Andrology & STDs Department, Kasr Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt.

Purpose: The purpose of the study was to compare serum level of folic acid (FA) in patients with erectile dysfunction (ED) versus healthy controls and to assess its correlation with other well-known confounders for ED.

Methods: Our prospective study compared FA in 60 patients with ED versus 30 healthy controls. Patients were excluded if they had any hormonal disorders, Peyronie's disease, or decompensated systemic illnesses. Read More

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December 2018

Disability trends in Canada: 2001-2014 population estimates and correlates.

Can J Public Health 2018 Dec 13. Epub 2018 Dec 13.

Social Science Centre, University of Western Ontario, 1151 Richmond Street, London, ON, N6G 2V4, Canada.

Objectives: Disability is a major concern for the health of midlife and older Canadians. Understanding disability trends is critical for detecting socio-economic and health precursors that could be amenable to policy interventions. The purpose of this study is to assess trends in rates of disability among Canadian adults age 40-64 and 65+. Read More

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December 2018

SIU-ICUD consultation on bladder cancer: basic science.

World J Urol 2018 Dec 13. Epub 2018 Dec 13.

Scott Department of Urology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.

Purpose: To provide a condensed summary of the Basic Science chapter that was included in the Third International Consultation on Bladder Cancer.

Methods: World bladder cancer basic science experts used the published literature to create summaries of recent progress in their areas of expertise.

Results: The completion of several large-scale genomics projects coupled with a strong collaborative culture within the research community and the exciting clinical activity of immune checkpoint blockade have combined to transform the bladder cancer research landscape. Read More

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December 2018

AAV8 Gene Therapy for Crigler-Najjar Syndrome in Macaques Elicited Transgene T Cell Responses That Are Resident to the Liver.

Mol Ther Methods Clin Dev 2018 Dec 5;11:191-201. Epub 2018 Dec 5.

Gene Therapy Program, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Systemic delivery of adeno-associated viral (AAV) vectors has been evaluated for the treatment of several liver diseases, including homozygous familial hypercholesterolemia, ornithine transcarbamylase deficiency, and hemophilia. Here, we evaluated this approach for the treatment of Crigler-Najjar syndrome. We administered wild-type rhesus macaques with 1. Read More

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December 2018

Alpha 1 Antitrypsin Gene Therapy Extends the Lifespan of Lupus-Prone Mice.

Mol Ther Methods Clin Dev 2018 Dec 18;11:131-142. Epub 2018 Oct 18.

Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by high levels of pathogenic autoantibodies and tissue damage. Multiple studies showed that dendritic cell (DC) activation plays a critical role in SLE pathogenesis. Human alpha 1 antitrypsin (hAAT) is a serine proteinase inhibitor with potent anti-inflammatory and cytoprotective properties. Read More

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December 2018

Clinical characterization of colitis arising from anti-PD-1 based therapy.

Oncoimmunology 2019 31;8(1):e1524695. Epub 2018 Oct 31.

Department of Medicine, Vanderbilt University, Nashville, TN, USA.

Colitis is a frequent, clinically-significant immune-related adverse event caused by anti-programmed death-1 (PD-1). The clinical features, timing, and management of colitis with anti-PD-1-based regimens are not well-characterized. Patients with advanced melanoma that received either anti-PD-1 monotherapy ("monotherapy") or combined with ipilimumab ("combination therapy") were screened from 8 academic medical centers, to identify those with clinically-relevant colitis (colitis requiring systemic steroids). Read More

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October 2018

Combination PD-1 blockade and irradiation of brain metastasis induces an effective abscopal effect in melanoma.

Oncoimmunology 2019 11;8(1):e1507669. Epub 2018 Oct 11.

Department of Immunology, Lerner Research Institute, Cleveland, OH, USA.

Nearly half of melanoma patients develop brain metastases during the course of their disease. Despite advances in both localized radiation and systemic immunotherapy, brain metastases remain difficult to treat, with most patients surviving less than 5 months from the time of diagnosis. While both treatment regimens have individually shown considerable promise in treating metastatic melanoma, there is interest in combining these strategies to take advantage of potential synergy. Read More

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October 2018
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Systemic autophagy in the therapeutic response to anthracycline-based chemotherapy.

Oncoimmunology 2019 1;8(1):e1498285. Epub 2018 Oct 1.

Gustave Roussy Comprehensive Cancer Institute, Villejuif, France.

The success of chemotherapy largely depends on the anticancer immune response triggered by tumor cells that succumb to immunogenic cell death (ICD). One of the hallmarks of ICD is premortem autophagy that facilitates the release of adenosine triphosphate from dying cancer cells and acts as a chemoattractant for dendritic cell precursors. Here, we show that the immune response induced by inoculation of cancer cells undergoing ICD in response to the anthracycline mitoxantrone (MTX) can be improved by a short-term fasting regimen (48 hours of starvation) and that this effect is reversed by systemic administration of the autophagy inhibitor dimethyl α-ketoglutarate. Read More

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October 2018

Analysis of serum macrophage migration inhibitory factor and D-dopachrome tautomerase in systemic sclerosis.

Clin Transl Immunology 2018 6;7(12):e1042. Epub 2018 Dec 6.

Centre for Inflammatory Diseases School of Clinical Sciences at Monash Health Monash University Clayton VIC Australia.

Objectives: Macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT), members of the same cytokine superfamily, are linked to the pathogenesis of a number of inflammatory diseases. The aim of this study was to investigate their clinical relevance in systemic sclerosis (SSc).

Methods: Serum MIF and DDT were quantified in 105 SSc patients by ELISA and levels compared to healthy controls (HC) (47) and patients with systemic lupus erythematosus (SLE) (184). Read More

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December 2018

The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension.

Oncotarget 2018 Nov 16;9(90):36220-36237. Epub 2018 Nov 16.

Department of Internal Medicine I, University of Bonn, Bonn, Germany.

Background And Aims: Angiogenesis is critically involved in the development of liver fibrosis, portal hypertension (PHT) and hepatocellular carcinoma (HCC). Regorafenib is a novel second-line therapy for HCC, but might also be beneficial in fibrosis and PHT even in absence of HCC. This study investigated the effects of regorafenib in experimental models without HCC. Read More

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November 2018

Transforming systems of consumption and production for achieving the sustainable development goals: moving beyond efficiency.

Sustain Sci 2018 25;13(6):1533-1547. Epub 2018 May 25.

5Institute for Development Studies, Brighton, UK.

The United Nations formulated the sustainable development goals (SDGs) in 2015 as a comprehensive global policy framework for addressing the most pressing social and environmental challenges currently facing humanity. In this paper, we analyse SDG 12, which aims to "ensure sustainable consumption and production patterns." Despite long-standing political recognition of this objective, and ample scientific evidence both on its importance and on the efficacy of various ways of promoting it, the SDGs do not provide clear goals or effective guidance on how to accomplish this urgently needed transformation. Read More

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Plant Immunity Is Compartmentalized and Specialized in Roots.

Front Plant Sci 2018 28;9:1692. Epub 2018 Nov 28.

Normandie Univ, UNIROUEN, Laboratoire Glycobiologie et Matrice Extracellulaire Végétale EA4358, Rouen, France.

Roots are important organs for plant survival. In recent years, clear differences between roots and shoots in their respective plant defense strategies have been highlighted. Some putative gene markers of defense responses usually used in leaves are less relevant in roots and are sometimes not even expressed. Read More

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November 2018

Anakinra in Still's disease: a profile of its use.

Drugs Ther Perspect 2018 31;34(12):543-553. Epub 2018 Oct 31.

Springer, Private Bag 65901, Mairangi Bay, 0754 Auckland, New Zealand.

The EU indication for anakinra has been extended to include Still's disease, a serious rare inflammatory disorder of unknown aetiology that comprises adult-onset Still's disease (AOSD) and systemic juvenile idiopathic arthritis (SJIA). As activated interleukin-1 pathways are associated with the systemic manifestations of these disorders, targeted treatment with anakinra, an interleukin-1 inhibitor, has been investigated. Across clinical and real-world studies in patients with AOSD and SJIA, treatment with anakinra achieved clinical remission/response, provided rapid and sustained improvements in systemic and laboratory manifestations, and allowed the use of corticosteroid- and disease-modifying anti-rheumatic drugs (DMARD) to be reduced or discontinued. Read More

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October 2018

Sympathetic skin response in patients with systemic sclerosis and rheumatoid arthritis.

Egypt J Neurol Psychiatr Neurosurg 2018 27;54(1):38. Epub 2018 Nov 27.

3Department of Neurology and Psychiatry, Aswan University Hospital, Aswan, Egypt.

Background: Sympathetic skin response (SSR) is a technique to assess the sympathetic cholinergic pathways. Sympathetic dysfunction may participate in the development of pain, which is the major complaint in patients with systemic sclerosis (SSc) and rheumatoid arthritis (RA).

Objectives: In this study, we aimed to assess the autonomic dysfunction in patients with (SSc) and (RA) using SSR as a simple neurophysiologic test. Read More

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November 2018

Radiation promotes systemic responses.

Authors:
Jordan Hindson

Nat Rev Immunol 2018 Dec 13. Epub 2018 Dec 13.

Nature Reviews Immunology, .

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December 2018

Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer.

Oncogene 2018 Dec 13. Epub 2018 Dec 13.

Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700, Fribourg, Switzerland.

Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however, there is no formal evidence for it. Here, we provide experimental evidence that ER breast cancer cells that survived high-dose Doxorubicin and Methotrexate based chemotherapies elicit a state of immunological dormancy. Read More

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December 2018

Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms.

Nat Commun 2018 Dec 13;9(1):5293. Epub 2018 Dec 13.

Department of Pathology and Cell Biology, Columbia University, New York, 10032, NY, USA.

We used allogeneic bone marrow transplantation (BMT) and a mouse multistage cutaneous carcinogenesis model to probe recruitment of bone marrow-derived epithelial cells (BMDECs) in skin tumors initiated with the carcinogen, dimethylbenz[a]anthracene (DMBA), and promoted with 12-O-tetradecanolyphorbol-13-acetate (TPA). BMDECs clustered in the lesional epithelium, expressed cytokeratins, proliferated, and stratified. We detected cytokeratin induction in plastic-adherent bone marrow cells (BMCs) cultured in the presence of filter-separated keratinocytes (KCs) and bone morphogenetic protein 5 (BMP5). Read More

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December 2018

Do All Patients With Polycythemia Vera or Essential Thrombocythemia Need Cytoreduction?

J Natl Compr Canc Netw 2018 Dec;16(12):1539-1545

Department of Medicine, and Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine; and Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois.

Polycythemia vera (PV) and essential thrombocythemia (ET) are Philadelphia chromosome-negative chronic myeloproliferative neoplasms (MPNs), characterized by expansion of normal blood counts, bleeding, thrombosis, and the potential for transformation to myelofibrosis (MF) or acute myeloid leukemia (AML). The primary goals of treatment for MPNs are to reduce the risk of thrombosis, alleviate systemic symptom burden (eg, fatigue, pruritus, microvascular symptoms, and symptomatic splenomegaly), and to prevent transformation to MF/AML. Preventing transformation is clearly important, but not expected with current therapies. Read More

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December 2018

Systemic Mastocytosis, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2018 Dec;16(12):1500-1537

Mastocytosis is a group of heterogeneous disorders resulting from the clonal proliferation of abnormal mast cells and their accumulation in the skin and/or in various extracutaneous organs. Systemic mastocytosis is the most common form of mastocytosis diagnosed in adults, characterized by mast cell infiltration of one or more extracutaneous organs (with or without skin involvement). The identification of KIT D816V mutation and the emergence of novel targeted therapies have significantly improved the diagnosis and treatment of systemic mastocytosis. Read More

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December 2018
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Much Ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localized oedema.

Clin Sci (Lond) 2018 Dec 13;132(24):2609-2613. Epub 2018 Dec 13.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.

Hypertonic Na accumulation in peripheral tissues is a recently described phenomenon: it has been associated with ageing, hypertension, diabetes, chronic kidney disease and heart failure, but its clinical meaning has yet to be determined. This concept conflicts with the classic physiological paradigm of constant balance between salt intake and excretion, and its water-independent nature is still a matter of debate.We developed a theoretical model explaining changes in the chemical composition of tissues as a function of extracellular volume fraction and excess extracellular fluid, i. Read More

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December 2018

Effect of alcohol ingestion on plasma glucose kinetics after Roux-en-Y gastric bypass surgery.

Surg Obes Relat Dis 2018 Nov 2. Epub 2018 Nov 2.

Department of Food Science and Human Nutrition, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois; Division of Nutritional Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois. Electronic address:

Background: Roux-en-Y gastric bypass surgery (RYGB) increases the rate of alcohol absorption so that peak blood alcohol concentration is 2-fold higher after surgery compared with concentrations reached after consuming the same amount presurgery. Because high doses of alcohol can lead to hypoglycemia, patients may be at increased risk of developing hypoglycemia after alcohol ingestion.

Objectives: We conducted 2 studies to test the hypothesis that the consumption of approximately 2 standard drinks of alcohol would decrease glycemia more after RYGB than before surgery. Read More

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November 2018
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The dose-response effects of uric acid on the prevalence of metabolic syndrome and electrocardiographic left ventricular hypertrophy in healthy individuals.

Nutr Metab Cardiovasc Dis 2018 Oct 16. Epub 2018 Oct 16.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan; Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, 10581, Taiwan; Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, 64057, Taiwan. Electronic address:

Background And Aim: Hyperuricemia (HUA) is associated with the prevalence of metabolic syndrome (MetS) and cardiovascular risks in various populations. HUA is also able to induce cardiomyocyte hypertrophy in mouse models. However, the dose-response effects of serum uric acid (SUA) on the prevalence of MetS and electrocardiographic left ventricular hypertrophy (LVH) are unclear. Read More

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October 2018

NtPR1a regulates resistance to Ralstonia solanacearum in Nicotiana tabacum via activating the defense-related genes.

Biochem Biophys Res Commun 2018 Dec 10. Epub 2018 Dec 10.

Laboratory of Natural Products Pesticides, College of Plant Protection, Southwest University, Chongqing, China. Electronic address:

Pathogenesis-related proteins (PRs) are associated with the development of systemic acquired resistance (SAR) against further infection enforced by fungi, bacteria and viruses. PR1a is the first PR-1 member that could be purified and characterized. Previous studies have reported its role in plants' resistance system against oomycete pathogens. Read More

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December 2018

Postpartum flare up of systemic lupus erythematosus: Pulmonary diffused alveolar hemorrhage.

Taiwan J Obstet Gynecol 2018 Dec;57(6):906-907

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:

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December 2018

Comprehensive analysis of oxidative stress markers and antioxidants status in preeclampsia.

Taiwan J Obstet Gynecol 2018 Dec;57(6):779-790

Department of Medical Biotechnology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.

Preeclampsia is a hypertensive disorder in pregnant women, which can be the leading cause of maternal and neonatal death or premature birth. Although the cause of preeclampsia is still not clear, local or systemic oxidative stress may explain the pathological features associated with this complication. However, it is not clear whether oxidative stress is the cause or the result of preeclampsia. Read More

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December 2018

Prognostic effect of factors involved in revised Tokuhashi score system for patients with spinal metastases: a systematic review and Meta-analysis.

BMC Cancer 2018 Dec 13;18(1):1248. Epub 2018 Dec 13.

Tianjin Medical university, Tianjin, 300070, China.

Background: Cancer patients' survival time has obviously improved, with the development of systemic treatment techniques. However, the probability of metastases to the vertebrae has also been increased which makes some adverse effects on patients' quality of life. The prediction of survival plays a key role in choosing therapeutic modality, and Tokuhashi Score was established as one of the most commonly used predictive systems for spinal metastases. Read More

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December 2018

Systemic analysis of urinary stones from the Northern, Eastern, Central, Southern and Southwest China by a multi-center study.

BMC Urol 2018 Dec 13;18(1):114. Epub 2018 Dec 13.

The Department of Clinical Laboratory, The Sixth People's Hospital of Nansha, Xingye Road No. 7, Dagang Town, Nansha, Guangzhou, 511470, People's Republic of China.

Background: To provide some basis for the prevention of urinary stones in general population, we did a systemic analysis of urinary stones from Northern, Eastern, Central, Southern and Southwest China by a multi-center study.

Methods: A total of 11,157 urinary stones from Northern, Eastern, Central, Southern and Southwest China were obtained and analyzed by Fourier transform infrared spectroscopy. Combined with scanning electron microscopy and X-ray energy spectrometer, urinary stones were classified into different types. Read More

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December 2018

Oviposition by on Alters the Plant's Response to Herbivory and Impairs Larval Performance.

Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.

Molecular Ecology, Dahlem Centre of Plant Sciences, Institute of Biology/Freie Universität Berlin, Albrecht-Thaer Weg 6, 14195, Berlin, Germany.

Plant resistance traits against insect herbivores are extremely plastic. Plants respond not only to the herbivory itself, but also to oviposition by herbivorous insects. How prior oviposition affects plant responses to larval herbivory is largely unknown. Read More

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December 2018

RVFV Infection in Goats by Different Routes of Inoculation.

Viruses 2018 Dec 12;10(12). Epub 2018 Dec 12.

Canadian Food Inspection Agency, Winnipeg, MB R3E 3M4, Canada.

Rift Valley fever virus (RVFV) is a zoonotic arbovirus of the Phenuiviridae family. Infection causes abortions in pregnant animals, high mortality in neonate animals, and mild to severe symptoms in both people and animals. There is currently an ongoing effort to produce safe and efficacious veterinary vaccines against RVFV in livestock to protect against both primary infection in animals and zoonotic infections in people. Read More

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December 2018

The Impact of Protein Acetylation/Deacetylation on Systemic Lupus Erythematosus.

Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA.

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease in which the body's immune system mistakenly attacks healthy cells. Although the exact cause of SLE has not been identified, it is clear that both genetics and environmental factors trigger the disease. Identical twins have a 24% chance of getting lupus disease if the other one is affected. Read More

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December 2018
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MRI Study of the Influence of Surface Coating Aging on the In Vivo Biodistribution of Iron Oxide Nanoparticles.

Biosensors (Basel) 2018 Dec 12;8(4). Epub 2018 Dec 12.

Magnetic Resonance Imaging Laboratory, CIC biomaGUNE, 20014 Donostia-San Sebastián, Spain.

Medical imaging is an active field of research that fosters the necessity for novel multimodal imaging probes. In this line, nanoparticle-based contrast agents are of special interest, since those can host functional entities either within their interior, reducing potential toxic effects of the imaging tracers, or on their surface, providing high payloads of probes, due to their large surface-to-volume ratio. The long-term stability of the particles in solution is an aspect usually under-tackled during probe design in research laboratories, since their performance is generally tested briefly after synthesis. Read More

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December 2018

Anti- Activity of Thiazolylhydrazone Derivatives in Invertebrate and Murine Models.

J Fungi (Basel) 2018 Dec 12;4(4). Epub 2018 Dec 12.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Pampulha, Belo Horizonte-Minas Gerais 31270-901, Brasil.

Candidiasis is an opportunistic fungal infection with being the most frequently isolated species. Treatment of these infections is challenging due to resistance that can develop during therapy, and the limited number of available antifungal compounds. Given this situation, the aim of this study was to evaluate the antifungal activity of four thiazolylhydrazone compounds against . Read More

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December 2018

Vertical and Horizontal Transmission of Pospiviroids.

Viruses 2018 Dec 12;10(12). Epub 2018 Dec 12.

Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Aomori 036-8561, Japan.

Viroids are highly structured, single-stranded, non-protein-coding circular RNA pathogens. Some viroids are vertically transmitted through both viroid-infected ovule and pollen. For example, potato spindle tuber viroid, a species that belongs to family, is delivered to the embryo through the ovule or pollen during the development of reproductive tissues before embryogenesis. Read More

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December 2018
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Inhibition of Ceramide De Novo Synthesis Affects Adipocytokine Secretion and Improves Systemic and Adipose Tissue Insulin Sensitivity.

Int J Mol Sci 2018 Dec 11;19(12). Epub 2018 Dec 11.

Department of Physiology, Medical University of Bialystok, Bialystok, Poland.

Ceramide accumulation in muscle and in liver is implicated in the induction of insulin resistance. Much less in known about the role of ceramide in adipose tissue. The aim of the present study was to elucidate the role of ceramide in adipose tissue and to clarify whether lipids participate in the regulation of adipocytokine secretion. Read More

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December 2018

The Relationship between Infectious Diseases and Housing Maintenance in Indigenous Australian Households.

Int J Environ Res Public Health 2018 Dec 11;15(12). Epub 2018 Dec 11.

School of Public Health, The University of Queensland, Brisbane 4006, Australia.

This research aimed to identify systemic housing-level contributions to infectious disease transmission for Indigenous Australians, in response to the Government program to 'close the gap' of health and other inequalities. A narrative literature review was performed in accordance to PRISMA guidelines. The findings revealed a lack of housing maintenance was associated with gastrointestinal infections, and skin-related diseases were associated with crowding. Read More

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December 2018

Exploring the Roles of Aquaporins in Plant⁻Microbe Interactions.

Cells 2018 Dec 11;7(12). Epub 2018 Dec 11.

Jiangsu Provincial Key Lab of Solid Organic Waste Utilization, Jiangsu Collaborative Innovation Center of Solid Organic Wastes, Educational Ministry Engineering Center of Resource-Saving Fertilizers, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China.

Aquaporins (AQPs) are membrane channel proteins regulating the flux of water and other various small solutes across membranes. Significant progress has been made in understanding the roles of AQPs in plants' physiological processes, and now their activities in various plant⁻microbe interactions are receiving more attention. This review summarizes the various roles of different AQPs during interactions with microbes which have positive and negative consequences on the host plants. Read More

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December 2018
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Oral Dysbiosis in Pancreatic Cancer and Liver Cirrhosis: A Review of the Literature.

Biomedicines 2018 Dec 11;6(4). Epub 2018 Dec 11.

Fondazione Novara Sviluppo, 28100 Novara, Italy.

The human body is naturally colonized by a huge number of different commensal microbial species, in a relatively stable equilibrium. When this microbial community undergoes dysbiosis at any part of the body, it interacts with the innate immune system and results in a poor health status, locally or systemically. Research studies show that bacteria are capable of significantly influencing specific cells of the immune system, resulting in many diseases, including a neoplastic response. Read More

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December 2018
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Metabolic Signature of Dietary Iron Overload in a Mouse Model.

Cells 2018 Dec 11;7(12). Epub 2018 Dec 11.

Department of Internal Medicine II, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.

Iron is an essential co-factor for several metabolic processes, including the Krebs cycle and mitochondrial oxidative phosphorylation. Therefore, maintaining an appropriate iron balance is essential to ensure sufficient energy production and to avoid excessive reactive oxygen species formation. Iron overload impairs mitochondrial fitness; however, little is known about the associated metabolic changes. Read More

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December 2018

Socio-Economic Status and Health: Evaluation of Human Biomonitored Chemical Exposure to Per- and Polyfluorinated Substances across Status.

Int J Environ Res Public Health 2018 Dec 11;15(12). Epub 2018 Dec 11.

Flemish Institute for Technological Research (VITO)-Sustainable Health, 2400 Mol, Belgium.

Research on the environment, health, and well-being nexus (EHWB) is shifting from a silo toward a systemic approach that includes the socio-economic context. To disentangle further the complex interplay between the socio-exposome and internal chemical exposure, we performed a meta-analysis of human biomonitoring (HBM) studies with internal exposure data on per-and polyfluoroalkyl substances (PFASs) and detailed information on risk factors, including descriptors of socio-economic status (SES) of the study population. PFASs are persistent in nature, and some have endocrine-disrupting properties. Read More

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December 2018

Preliminary Study of the Effect of Stereotactic Body Radiotherapy (SBRT) on the Immune System in Lung Cancer Patients Unfit for Surgery: Immunophenotyping Analysis.

Int J Mol Sci 2018 Dec 9;19(12). Epub 2018 Dec 9.

Radiation Oncology Department, Hospital Duran i Reynals, Institut Català d'Oncologia (ICO), Radiobiology and Cancer Group, ONCOBELL Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Avinguda de la Gran Via de l'Hospitalet 199-203, L'Hospitalet de Llobregat, 08098 Barcelona, Spain.

An immunophenotyping analysis was performed in peripheral blood samples from seven patients with lung cancer unfit for surgery treated with stereotactic body radiotherapy (SBRT). The objective was to characterize the effect of SBRT on the host immune system. Four patients received 60 Gy (7. Read More

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December 2018

Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice.

Int J Mol Sci 2018 Dec 9;19(12). Epub 2018 Dec 9.

Faculty and Graduate School of Health and Sports Science, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe, Kyoto 610-0394, Japan.

Although the body's immune system is altered during spaceflight, the effects of microgravity (μ) on tumor growth and carcinogenesis are, as yet, unknown. To assess tumor proliferation and its effects on the immune system, we used a hind-limb unloading (HU) murine model to simulate μ during spaceflight. HU mice demonstrated significantly increased tumor growth, metastasis to the lung, and greater splenic and thymic atrophy compared with mice in constant orthostatic suspension and standard housing controls. Read More

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December 2018

Decreases Endothelial Damage and Oxidative Stress Indicators in Patients with Systemic Arterial Hypertension: Results from Exploratory Controlled Clinical Trial.

Mar Drugs 2018 Dec 8;16(12). Epub 2018 Dec 8.

Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.

(1) Background: () has shown beneficial effects such as being anti-dyslipidemic, antiviral, antioxidant and antihypertensive. However, there are few and limited clinical studies. (2) Methods: a prospective, randomized, parallel pilot study of 4. Read More

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December 2018

From mRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation during Zebrafish Embryonic and Larval Development.

Int J Mol Sci 2018 Dec 10;19(12). Epub 2018 Dec 10.

Applied Veterinary Morphology, Department of Veterinary Sciences, University of Antwerp, Wilrijk 2610, Antwerp, Belgium.

The zebrafish () embryo is currently explored as an alternative for developmental toxicity testing. As maternal metabolism is lacking in this model, knowledge of the disposition of xenobiotics during zebrafish organogenesis is pivotal in order to correctly interpret the outcome of teratogenicity assays. Therefore, the aim of this study was to assess cytochrome P450 (CYP) activity in zebrafish embryos and larvae until 14 d post-fertilization (dpf) by using a non-specific CYP substrate, i. Read More

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December 2018

Development of Pranoprofen Loaded Nanostructured Lipid Carriers to Improve Its Release and Therapeutic Efficacy in Skin Inflammatory Disorders.

Nanomaterials (Basel) 2018 Dec 7;8(12). Epub 2018 Dec 7.

Department of Chemical and Instrumental Analysis, Faculty of Chemistry and Pharmacy, University of El Salvador, Ciudad Universitaria, 3026 San Salvador, El Salvador.

Pranoprofen (PF)-loaded nanostructured lipid carriers (NLCs), prepared using a high-pressure homogenization method, have been optimized and characterized to improve the biopharmaceutical profile of the drug. The optimized PF-NLCs exhibited physicochemical characteristics and morphological properties that were suitable for dermal application. Stability assays revealed good physical stability, and the release behavior of PF from these NLCs showed a sustained release pattern. Read More

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December 2018

Different Pathogen Defense Strategies in : More than Pathogen Recognition.

Cells 2018 Dec 7;7(12). Epub 2018 Dec 7.

Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.

Plants constantly suffer from simultaneous infection by multiple pathogens, which can be divided into biotrophic, hemibiotrophic, and necrotrophic pathogens, according to their lifestyles. Many studies have contributed to improving our knowledge of how plants can defend against pathogens, involving different layers of defense mechanisms. In this sense, the review discusses: (1) the functions of PAMP (pathogen-associated molecular pattern)-triggered immunity (PTI) and effector-triggered immunity (ETI), (2) evidence highlighting the functions of salicylic acid (SA) and jasmonic acid (JA)/ethylene (ET)-mediated signaling pathways downstream of PTI and ETI, and (3) other defense aspects, including many novel small molecules that are involved in defense and phenomena, including systemic acquired resistance (SAR) and priming. Read More

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December 2018