J Rheumatol 2017 Sep 15. Epub 2017 Sep 15.
From the University of Utah, Department of Internal Medicine, and the Department of Exercise and Sport Science, and the Department of Biochemistry; VA Salt Lake City, Geriatric Research, Education, and Clinical Center (GRECC), Salt Lake City, Utah, USA; Maastricht University, Department of Physiology, Maastricht, the Netherlands; MicroVascular Health Solutions LLC, Alpine, Utah, USA. Supported by the US National Institutes of Health (R01 AG040297 to AJD, K23 AR067889 to TMF, and K02 AG045339 to AJD); and the US Department of Veterans Affairs (I01 CX001183 to TMF). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. HV is chief scientific officer at MicroVascular Health Solutions LLC and reports personal fees from GlycoCheck BV and MicroVascular Health Solutions LLC outside the submitted work. In addition, HV has a patent (WO2009068685): Diagnostic and Therapeutic Tools for Diseases Altering Vascular Function. D.R. Machin, PhD, University of Utah, Department of Internal Medicine, and VA Salt Lake City, GRECC; P.E. Gates, PhD, University of Utah, Department of Internal Medicine; H. Vink, PhD, Maastricht University, Department of Physiology, and MicroVascular Health Solutions LLC; T.M. Frech, MD, University of Utah, Department of Internal Medicine; A.J. Donato, PhD, University of Utah, Department of Internal Medicine, Department of Exercise and Sport Science, Department of Biochemistry, and VA Salt Lake City, GRECC. Address correspondence to A.J. Donato, VA Medical Center, SLC, 500 Foothill Drive, GRECC, Bldg 2, Rm 2D15A, Salt Lake City, Utah 84148, USA. E-mail: Accepted for publication June 21, 2017.
: The aim of our study was to determine whether an automated capture and analysis system could detect differences in structure and function of sublingual microvessels in patients with systemic sclerosis (SSc) compared to healthy controls.Methods
: Intravital microscopy of the sublingual microcirculation was automatically captured and analyzed in 40 patients with SSc and 10 age-matched healthy controls.Results
: Total and perfused microvascular density were lower in patients with SSc compared with controls (total microvascular density: 2471 ± 134 μm/mm(2) vs 3067 ± 197 μm/mm(2), p = 0. Read More