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    Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment.
    Auto Immun Highlights 2017 Nov 16;8(1):12. Epub 2017 Nov 16.
    Graduate Program in Immunology, Program in Biomedical Sciences, University of Michigan Medical School, Ann Arbor, USA.
    The clinical success of anti-CD20 monoclonal antibody (mAb)-mediated B cell depletion therapy has contributed to the understanding of B cells as major players in several autoimmune diseases. The first therapeutic anti-CD20 mAb, rituximab, is a murine-human chimera to which many patients develop antibodies and/or experience infusion-related reactions. A second generation of anti-CD20 mAbs has been designed to be more effective, better tolerated, and of lower immunogenicity. Read More

    All-cause Healthcare Costs and Mortality in Patients with Systemic Sclerosis with Lung Involvement.
    J Rheumatol 2017 Nov 15. Epub 2017 Nov 15.
    From the University of Colorado School of Medicine, Denver, Colorado; Truven Health Analytics, an IBM Company, Cambridge, Massachusetts; National Jewish Health, Denver, Colorado; Genentech Inc., South San Francisco, California, USA. This analysis was funded by Genentech Inc., and F. Hoffmann-La Roche Ltd. A. Fischer, MD, University of Colorado School of Medicine; A.M. Kong, MPH, Truven Health Analytics, an IBM Company; J.J. Swigris, DO, MS, National Jewish Health; A.L. Cole, MPH, Truven Health Analytics; K. Raimundo, MS, Genentech Inc. Address correspondence to K. Raimundo, Genentech, 1 DNA Way, South San Francisco, California 94080, USA. E-mail: Accepted for publication August 11, 2017.
    Objective: Patients with systemic sclerosis (SSc) often develop interstitial lung disease (ILD) and/or pulmonary arterial hypertension (PAH). The effect of ILD and PAH on healthcare costs among patients with SSc is not well described. The objective of this analysis was to describe healthcare costs in patients with newly diagnosed SSc and SSc patients newly diagnosed with ILD and/or PAH in the United States. Read More

    High Baseline Serum Clara Cell 16 kDa Predicts Subsequent Lung Disease Worsening in Systemic Sclerosis.
    J Rheumatol 2017 Nov 15. Epub 2017 Nov 15.
    From the Internal Medicine Department, AP-HP Saint-Antoine Hospital, Pierre and Marie Curie University; Physiology Department, AP-HP Cochin Hospital, Paris Descartes University, Sorbonne Paris Cité, Paris; Unité de Médecine Interne, Hôpital Pasteur, Vitry-sur-Seine, France. Supported by grants from the Legs Poix, University of Paris, and the Air Liquide Foundation. S. Rivière, MD, Internal Medicine Department, AP-HP Saint-Antoine Hospital, Pierre and Marie Curie University; T. Hua-Huy, MD, PhD, Physiology Department, AP-HP Cochin Hospital, Paris Descartes University, Sorbonne Paris Cité; K.P. Tiev, MD, PhD, Unité de Médecine Interne, Hôpital Pasteur; J. Cabane, MD, Internal Medicine Department, AP-HP Saint-Antoine Hospital, Pierre and Marie Curie University; A.T. Dinh-Xuan, MD, PhD, Physiology Department, AP-HP Cochin Hospital, Paris Descartes University, Sorbonne Paris Cité. Address correspondence to Dr. A.T. Dinh-Xuan, 27 rue Faubourg Saint-Jacques, 75679 Paris Cedex 14, France. E-mail: Accepted for publication September 1, 2017.
    Objective: Clara cell secretory protein (CC16) is a sensitive marker of bronchial epithelial cell damage. The CC16 serum level is elevated in patients with pulmonary fibrosis, but its predictive value on lung disease progression has not yet been studied. We aimed to assess the value of serum CC16 concentration in predicting lung disease deterioration in patients with systemic sclerosis (SSc). Read More

    Alternative diagnoses in patients referred to specialized centers for suspected MS.
    Mult Scler Relat Disord 2017 Nov 21;18:85-89. Epub 2017 Sep 21.
    Neurology, Amiri Hospital, Kuwait City, Kuwait.
    Objectives: The aim of this study is to explore the frequency, type, and predictors of alternative diagnoses among patients referred with a recent diagnosis of multiple sclerosis (MS) to two specialized MS centers in the Middle East.

    Methods: This is a retrospective review of a prospectively followed cohort of MS patients at 2 University specialized MS centers. All patients referred for MS were included. Read More

    Anti-inflammatory activity of extra virgin olive oil polyphenols: which role in the prevention and treatment of immune-mediated inflammatory diseases?
    Endocr Metab Immune Disord Drug Targets 2017 Nov 13. Epub 2017 Nov 13.
    Istituto Superiore di Sanita, Center for Gender-specific Medicine, Viale Regina Elena 299; 00161 Rome. Italy.
    Altered inflammatory response characterizes chronic immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, and psoriasis. Accumulating evidence indicates that regular consumption of extra virgin olive oil (EVOO), the main source of fat in the Mediterranean diet, is associated with a reduced risk of developing chronic degenerative disorders such cardiovascular diseases, type 2 diabetes and cancer. The beneficial effects on health of EVOO have been attributed, besides to the monounsaturated fats content, to the presence of phenolic compounds that have antioxidant, anti-inflammatory and immunomodulatory properties. Read More

    Identification of novel systemic sclerosis biomarkers employing aptamer proteomic analysis.
    Rheumatology (Oxford) 2017 Nov 13. Epub 2017 Nov 13.
    Jefferson Institute of Molecular Medicine and The Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, USA.
    There is an important unmet need for clinically validated non-invasive biomarkers for SSc diagnosis, assessment of disease activity, extent of internal organ involvement, therapeutic response and prognosis. There is also an unmet need for biomarkers to accurately differentiate primary RP from recent onset RP evolving into SSc. The lack of sensitive and specific biomarkers for SSc and SSc-associated RP is a limitation for the optimal clinical management of these patients. Read More

    Vitamin D levels in systemic sclerosis patients: a meta-analysis.
    Drug Des Devel Ther 2017 27;11:3119-3125. Epub 2017 Oct 27.
    Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, People's Republic of China.
    Purpose: This study aimed to investigate the association between vitamin D and systemic sclerosis (SSc) by meta-analysis.

    Methods: A comprehensive search was performed through June 12, 2017. Pooled standardized mean difference (SMD) was used to estimate the mean vitamin D difference between case and control groups (or between diffused- and limited-type SSc). Read More

    Localized Scleroderma, Systemic Sclerosis and Cardiovascular Risk: A Danish Nationwide Cohort Study.
    Acta Derm Venereol 2017 Nov 14. Epub 2017 Nov 14.
    Department of Dermatology and Allergy, Herlev and Gentofte University Hospital, University of Copenhagen, Kildegaardsvej 28, DK-2900 Hellerup, Denmark.
    Recent findings indicate that patients with systemic sclerosis have an increased risk of cardiovascular disease. To determine whether patients with systemic sclerosis or localized scleroderma are at increased risk of cardiovascular disease, a cohort study of the entire Danish population aged ≥ 18 and ≤ 100 years was conducted, followed from 1997 to 2011 by individual-level linkage of nationwide registries. Multivariable adjusted Cox regression models were used to estimate the hazard ratios (HRs) for a composite cardiovascular disease endpoint. Read More

    [Re-engineering of glucose exposure in peritoneal dialysis].
    Orv Hetil 2017 Oct;158(43):1708-1714
    B. Braun Avitum Hungary 1. Sz. Dialízisközpont, Szent Imre Egyetemi Oktatókórház, Nephrologia-Hypertonia Profil és Aktív Geriátriai Részleg Budapest.
    The significance of peritoneal dialysis in kidney replacement therapy is expected to increase, so it is important to reconsider glucose exposure to minimize the adverse effects. The first step was to develop biocompatible modern PD solutions to reduce the local and systemic adverse effects of current conventional glucose-based ones. According to the limited clinical experience, there are no clear data on better clinical outcome. Read More

    The Plasma Levels of ADAMTS-13, von Willebrand Factor, VWFpp, and Fibrin-Related Markers in Patients With Systemic Sclerosis Having Thrombosis.
    Clin Appl Thromb Hemost 2017 Jan 1:1076029617736382. Epub 2017 Jan 1.
    1 Department of Dermatology, Mie University Graduate School of Medicine, Mie, Tsu, Japan.
    This study aimed to examine the hemostatic abnormalities in patients with systemic sclerosis (SSc) and the relationship between these abnormalities and thrombotic events (THEs), focusing on the difference in diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc (lcSSc). The plasma levels of ADAMTS-13 (a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13), von Willebrand factor (VWF), VWF propeptide (VWFpp), d-dimer, and soluble fibrin (SF) were measured in 233 patients with SSc. The relationship between their levels and organ involvement, including THEs and interstitial lung disease (ILD), was evaluated. Read More

    Increased frequencies of circulating CXCL10-, CXCL8- and CCL4-producing monocytes and Siglec-3-expressing myeloid dendritic cells in systemic sclerosis patients.
    Inflamm Res 2017 Nov 10. Epub 2017 Nov 10.
    Blood and Transplantation Center of Coimbra, Portuguese Institute of Blood and Transplantation, Coimbra, Portugal.
    Objective: To investigate the ex vivo pro-inflammatory properties of classical and non-classical monocytes as well as myeloid dendritic cells (mDCs) in systemic sclerosis (SSc) patients.

    Methods: Spontaneous production of CXCL10, CCL4, CXCL8 and IL-6 was intracellularly evaluated in classical, non-classical monocytes and Siglec-3-expressing mDCs from peripheral blood of SSc patients and healthy controls (HC) through flow cytometry. In addition, production of these cytokines was determined upon toll-like receptor (TLR) 4 plus Interferon-γ (IFN-γ) stimulation. Read More

    Dendritic cells in systemic sclerosis: advances from human and mice studies.
    Immunol Lett 2017 Nov 7. Epub 2017 Nov 7.
    Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Electronic address:
    Systemic sclerosis (SSc) is a complex heterogeneous fibrotic autoimmune disease with an unknown exact etiology, and characterized by three hallmarks: fibrosis, vasculopathy, and immune dysfunction. Dendritic cells (DCs) are specialized cells in pathogen sensing with high potency of antigen presentation and capable of releasing mediators to shape the immune response. Altered DCs distributions and their impaired functions may account for their role in breaking the immune tolerance and driving inflammation in SSc, and the direct contribution of DCs in promoting endothelial dysfunction and fibrotic process has only begun to be understood. Read More

    2013 ACR/EULAR systemic sclerosis classification criteria in patients with associated pulmonary arterial hypertension.
    Semin Arthritis Rheum 2017 Oct 13. Epub 2017 Oct 13.
    Servicio de Reumatología, Hospital Universitario12 de Octubre, Universidad Complutense de Madrid, Avda de Córdoba s/n, Madrid 28041, Spain. Electronic address:
    Objective: To analyze the performance of the 1980 ACR and new 2013 ACR/EULAR criteria for systemic sclerosis (SSc) in cutaneous SSc (lcSSc) patients, especially those affected by lcSSc and pulmonary arterial hypertension (PAH).

    Methods: All patients with a clinical lcSSc diagnosis from a prospective observational SSc cohort were included. Sociodemographic and disease-related variables were collected, and PAH confirmed by right heart catheterization (RHC). Read More

    Patient Preferences for Treatments of Neuromuscular Diseases: A Systematic Literature Review.
    J Neuromuscul Dis 2017 Nov 8. Epub 2017 Nov 8.
    MRC Centre for Neuromuscular Diseases, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
    Background: Treatment decisions of neuromuscular diseases involve weighing clinical benefits and risks, as well as impact on patient social life, work status, other activities of daily living, and health-related quality of life.

    Objective: To conduct a systemic literature review of patient preferences for treatments of neuromuscular diseases.

    Methods: We searched Embase, Web of Science, and PubMed for full-text articles reporting results from studies of patient preferences for treatments of neuromuscular diseases. Read More

    Systemic sclerosis and the gastrointestinal tract.
    Prz Gastroenterol 2017 30;12(3):163-168. Epub 2017 Sep 30.
    Clinical Department of Dermatology, Central Clinical Hospital of the MSWiA, Warsaw, Poland.
    Systemic sclerosis (SSc) is an autoimmunological disease of unknown origin with complex pathogenesis and multiple organ involvement. It is characterised by vascular and immunological abnormalities leading to fibrosis of the skin and internal organs. It is a rather rare disease with a prevalence of around 20 per 100,000. Read More

    Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease.
    PLoS One 2017 9;12(11):e0187580. Epub 2017 Nov 9.
    Northwestern Scleroderma Program, Feinberg School of Medicine, Chicago, IL, United States of America.
    Background: There are no effective treatments or validated clinical response markers in systemic sclerosis (SSc). We assessed imaging biomarkers and performed gene expression profiling in a single-arm open-label clinical trial of tyrosine kinase inhibitor dasatinib in patients with SSc-associated interstitial lung disease (SSc-ILD).

    Methods: Primary objectives were safety and pharmacokinetics. Read More

    Bench to Bedside - and Back Again: Finding the Goldilocks Zone within the Scleroderma Universe.
    Arthritis Rheumatol 2017 Nov 9. Epub 2017 Nov 9.
    Royal Free Hospital and UCL Medical School, Centre of rRheumatology.
    Systemic sclerosis (SSc) is a complex inflammatory connective tissue disease characterized by skin thickening, organ fibrosis and vasculopathy [1, 2]. The underlying disease mechanisms and pathophysiology are not fully understood. However, it appears to be, at least in part, driven by autoimmunity and inflammation associated with microvascular dysfunction ultimately resulting in excess extracellular matrix deposition in target organs [2-4]. Read More

    Imaging findings in systemic childhood diseases presenting with dermatologic manifestations.
    Clin Imaging 2017 Oct 31;49:17-36. Epub 2017 Oct 31.
    Department of Radiology, Division of Pediatric Radiology, Montefiore Medical Center, Bronx, NY, United States. Electronic address:
    Purpose: Many childhood diseases often present with skin abnormalities with which radiologists are largely unfamiliar. Knowledge of associated dermatologic manifestations may aid the radiologist in confirming the diagnosis and recommending targeted imaging of affected organs.

    Methods: We review the imaging findings in childhood diseases associated with dermatologic manifestations. Read More

    Orthopedic complications of linear morphea: Implications for early interdisciplinary care.
    Pediatr Dermatol 2017 Nov 9. Epub 2017 Nov 9.
    Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
    Linear morphea of the limb primarily affects children, and extracutaneous manifestations are common. Orthopedic surgeons are often essential in the care of patients with linear morphea, yet there are few reports outlining specific orthopedic complications in this population. We sought to improve the understanding of orthopedic complications in linear morphea of the limb. Read More

    Rituximab treatment in patients with systemic sclerosis and interstitial lung disease.
    Ann Thorac Med 2017 Oct-Dec;12(4):294-297
    Department of Medical Specialties, Rheumatology Section, King Fahad Medical City, Riyadh, KSA.
    There is increasing interest in rituximab (RTX) as an alternative to cyclophosphamide for the treatment of interstitial lung diseases (ILDs) associated with systemic sclerosis (SSc). However, no report has addressed its efficacy in Saudi patients with SSc-ILD. To assess the efficacy of RTX treatment in Saudi patients with SSc-ILD, hospital records were reviewed between 2013 and 2016. Read More

    Determinants of mortality in systemic sclerosis: a focused review.
    Rheumatol Int 2017 Nov 7. Epub 2017 Nov 7.
    Division of Rheumatology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
    Scleroderma (systemic sclerosis) is an autoimmune rheumatic disorder that is characterized by fibrosis, vascular dysfunction, and autoantibody production that involves most visceral organs. It is characterized by a high morbidity and mortality rate, mainly due to disease-related complications. Epidemiological data describing mortality and survival in this population have been based on both population and observational studies. Read More

    Increased stiffness of median nerve in systemic sclerosis.
    BMC Musculoskelet Disord 2017 Nov 7;18(1):434. Epub 2017 Nov 7.
    Marmara University Hospital, Rheumatology Department, Istanbul, Turkey.
    Background: Systemic sclerosis can affect peripheral nerves, but the extent and the nature of this involvement are not well defined. The aim of this study is to compare the sonoelastrographic measurements of median nerves in systemic sclerosis (SSC), idiopathic carpal tunnel syndrome (CTS) and healthy individuals.

    Methods: The clinical, electrophysiological and ultrasonographic assessments were done. Read More

    Skin Biomechanical Properties in patients with systemic sclerosis: what parameter should be used?
    J Eur Acad Dermatol Venereol 2017 Nov 8. Epub 2017 Nov 8.
    HP2 laboratory, Univ. Grenoble Alpes, F-38000, Grenoble, France.
    In systemic sclerosis (SSc), assessment of the skin's elasticity is a key parameter for diagnosis, patient classification and follow-up. The Rodnan score is currently the gold standard, but it suffers from intra-observer and inter-observer variability [1,2]. Skin elasticity has been assessed with cutometry in several clinical studies involving SSc patients, and compared to the Rodnan clinical score [3-5]. Read More

    Optic neuritis: Observation and experience at a tertiary care hospital in Qassim region, Saudi Arabia.
    Int J Health Sci (Qassim) 2017 Nov-Dec;11(5):30-34
    Ophthalmology Department, King Fahad Specialist Hospital Buraidah Al Qassim, Saudi Arabia.
    Objectives: Optic neuritis (ON) can occur in isolation or association with multiple sclerosis (MS) or neuromyelitis optica. ON, is seen more commonly in Caucasians and interaction is found to exist between ethnic origin and the latitude at which the patient grows up. At present limited information is available about the profile of ON in Saudi patients. Read More

    Targeting of cadherin-11 decreases skin fibrosis in the tight skin-1 mouse model.
    PLoS One 2017 7;12(11):e0187109. Epub 2017 Nov 7.
    Section of Immunology, Allergy, and Rheumatology, Biology of Inflammation Center, Department of Medicine, Baylor College of Medicine, Houston, TX, United States of America.
    Objective: Systemic sclerosis (SSc) is an autoimmune disease clinically manifesting as progressive fibrosis of the skin and internal organs. Cadherin-11 (CDH11) expression is increased in fibrotic skin and lung tissue. Targeting CDH11 may be an effective approach to treating fibrosis. Read More

    Abnormal esophageal acid exposure on high-dose proton pump inhibitor therapy is common in systemic sclerosis patients.
    Neurogastroenterol Motil 2017 Nov 6. Epub 2017 Nov 6.
    Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
    Background: Esophageal dysfunction and gastro-esophageal reflux disease (GERD) are common among patients with systemic sclerosis (SSc). Although high-dose proton pump inhibitors (PPIs) typically normalize esophageal acid exposure, the effectiveness of PPI therapy has not been systematically studied in SSc patients. The aim of this study was to characterize reflux in SSc patients on high-dose PPI using esophageal pH-impedance testing. Read More

    Physical activity and autoimmune diseases: Get moving and manage the disease.
    Autoimmun Rev 2017 Nov 3. Epub 2017 Nov 3.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:
    Physical activity, by definition, is any skeletal muscle body movement that results in energy expenditure. In the last few decades, a plethora of scientific evidences have accumulated and confirmed the beneficial role of physical activity as a modifiable risk factor for a wide variety of chronic diseases including cardiovascular diseases (CVDs), diabetes mellitus and cancer, among others. Autoimmune diseases are a heterogeneous group of chronic diseases, which occur secondary to loss of self-antigen tolerance. Read More

    MRI measurements of Blood-Brain Barrier function in dementia: A review of recent studies.
    Neuropharmacology 2017 Oct 28. Epub 2017 Oct 28.
    MIND Research Network, Albuquerque, NM, USA.
    Blood-brain barrier (BBB) separates the systemic circulation and the brain, regulating transport of most molecules to protect the brain microenvironment. Multiple structural and functional components preserve the integrity of the BBB. Several imaging modalities are available to study disruption of the BBB. Read More

    Targeting interferons as a strategy for systemic sclerosis treatment.
    Immunol Lett 2017 Oct 26. Epub 2017 Oct 26.
    National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland.
    Systemic Sclerosis (SSc) is an autoimmune disease characterised by vasculopathy, uncontrolled inflammation and enhanced fibrosis which can subsequently lead to the loss of organ function or even premature death. Interferons (IFNs) are pleiotropic cytokines that are critical not only in mounting an effective immune response against viral and bacterial infections but also strongly contribute to the pathogenesis of SSc. Furthermore, elevated levels of IFNs are found in SSc patients and correlate with skin thickness and disease activity suggesting potential role of IFNs as biomarkers. Read More

    Innate Immunity and Neurodegeneration.
    Annu Rev Med 2017 Nov 6. Epub 2017 Nov 6.
    Institute of Innate Immunity, University Hospitals Bonn, Bonn 53127, Germany; email:
    The innate immune system plays diverse roles in health and disease. It represents the first line of defense against infection and is involved in tissue repair, wound healing, and clearance of apoptotic cells and cellular debris. Excessive or nonresolving innate immune activation can lead to systemic or local inflammatory complications and cause or contribute to the development of inflammatory diseases. Read More

    Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives.
    Nat Rev Neurol 2017 Nov 6. Epub 2017 Nov 6.
    INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Purpan Hospital, Place du Docteur Baylac TSA 40031, 31059 Toulouse Cedex 9, France, and the Department of Immunology, Hôpital Rangueil, 1, Avenue du Professeur Jean Poulhès - TSA 50032 - 31059 Toulouse Cedex 9, France.
    Cancer treatment strategies based on immune stimulation have recently entered the clinical arena, with unprecedented success. Immune checkpoint inhibitors (ICIs) work by indiscriminately promoting immune responses, which target tumour-associated antigens or tumour-specific mutations. However, the augmented immune response, most notably the T cell response, can cause either direct neurotoxicity or, more commonly, indirect neurotoxic effects through systemic or local inflammatory mechanisms or autoimmune mechanisms. Read More

    The Emerging Role of the Major Histocompatibility Complex Class I in Amyotrophic Lateral Sclerosis.
    Int J Mol Sci 2017 Nov 1;18(11). Epub 2017 Nov 1.
    Department of Structural and Functional Biology, Institute of Biology-Unicamp, 13083-865 Campinas, Brazil.
    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting upper and lower motoneurons (MNs). The etiology of the disease is still unknown for most patients with sporadic ALS, while in 5-10% of the familial cases, several gene mutations have been linked to the disease. Mutations in the gene encoding Cu, Zn superoxide dismutase (SOD1), reproducing in animal models a pathological scenario similar to that found in ALS patients, have allowed for the identification of mechanisms relevant to the ALS pathogenesis. Read More

    Impact of multiple sclerosis on quality of life: Comparison with systemic lupus erythematosus.
    Clin Neurol Neurosurg 2017 Dec 31;163:149-155. Epub 2017 Oct 31.
    Section of Neurology, Hospital Carlos G. Durand, Buenos Aires, Argentina.
    Objective: To report the impact of multiple sclerosis (MS) on patients' quality of life (QoL) compared to systemic lupus erythematosus (SLE) using the 36-Item Short Form (SF-36) health questionnaire in Argentina.

    Patients And Methods: Cross-sectional study. All consecutive MS patients, SLE and healthy controls (HC) were included. Read More

    [Myelitis as a differential diagnosis of spinal cord tumors].
    Neurochirurgie 2017 Nov 6;63(5):349-355. Epub 2017 Nov 6.
    Clinique neurologique, université de Lille Nord de France, CHU de Lille, Lille, France.
    Background And Purpose: Myelitis is common, related to multiple aetiologies and constitute in some cases a differential diagnosis for spinal cord tumors. Our objective was to review the clinical and paraclinical aspects of the main aetiologies of myelitis.

    Methods: These aetiologies will be reviewed based on data not only from the scientific literature but also from our personal experience reported in different cohorts of patients. Read More

    Changes in Healthcare Spending After Diagnosis of Comorbidities Among Endometriosis Patients: A Difference-in-Differences Analysis.
    Adv Ther 2017 Nov 3. Epub 2017 Nov 3.
    Colorado Center for Reproductive Medicine, Lone Tree, CO, USA.
    Introduction: We sought to characterize changes in healthcare spending associated with the onset of 22 endometriosis-related comorbidities.

    Methods: Women aged 18-49 years with endometriosis (N = 180,278) were extracted from 2006-2015 de-identified Clinformatics(®) DataMart claims data. For 22 comorbidities, comorbidity patients were identified on the basis of having a first comorbidity diagnosis after their initial endometriosis diagnosis. Read More

    Novel candidate genes of the PARK7 interactome as mediators of apoptosis and acetylation in multiple sclerosis: An in silico analysis.
    Mult Scler Relat Disord 2017 Oct 24;19:8-14. Epub 2017 Oct 24.
    Department of Neurology, Faculty of Medicine, University of Thessaly, BIOPOLIS, Larissa 41110, Greece.
    Background: currently only 4 studies have explored the potential role of PARK7's dysregulation in MS pathophysiology Currently, no study has evaluated the potential role of the PARK7 interactome in MS.

    Objective: The aim of our study was to assess the differential expression of PARK7 mRNA in peripheral blood mononuclears (PBMCs) donated from MS versus healthy patients using data mining techniques.

    Methods: The PARK7 interactome data from the GDS3920 profile were scrutinized for differentially expressed genes (DEGs); Gene Enrichment Analysis (GEA) was used to detect significantly enriched biological functions. Read More

    Gut microbiota profile in systemic sclerosis patients with and without clinical evidence of gastrointestinal involvement.
    Sci Rep 2017 Nov 1;7(1):14874. Epub 2017 Nov 1.
    Dipartimento di Scienze e Tecnologie Alimentari per una filiera agroalimentare sostenibile (DiSTAS), Facoltà di Scienze Agrarie, Alimentari ed Ambientali, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122, Piacenza, Italy.
    Recent evidence suggests that there is a link between the gut microbial community and immune-mediated disorders. Systemic sclerosis (SSc) is an autoimmune disease characterized by immunonological abnormalities, vascular lesions, and extensive fibrosis. Since the gastrointestinal tract is one of the organs most involved, the goal of this study was to explore the composition of the intestinal microbiota in SSc patients with (SSc/GI+) and without gastrointestinal involvement (SSc/GI-) in comparison to healthy controls (HC). Read More

    Nodular Regenerative Hyperplasia of the Liver: A Rare Vascular Complication in Systemic Sclerosis.
    J Rheumatol 2017 Nov 1. Epub 2017 Nov 1.
    From the Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland. L. Graf, cand.med., Department of Rheumatology, University Hospital Zurich; R. Dobrota, MD, Department of Rheumatology, University Hospital Zurich; S. Jordan, MD, Department of Rheumatology, University Hospital Zurich; L.M. Wildi, MD, Department of Rheumatology, University Hospital Zurich; O. Distler, MD, Department of Rheumatology, University Hospital Zurich; B. Maurer, MD, Department of Rheumatology, University Hospital Zurich. Address correspondence to Dr. B. Maurer, Department of Rheumatology, University Hospital Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland. E-mail: Accepted for publication September 8, 2017.
    Objective: To investigate nodular regenerative hyperplasia (NRH) as a vascular complication of systemic sclerosis (SSc) with microvasculopathy as a common denominator.

    Methods: Cases of SSc-NRH were identified by systematic literature review and by screening the Zurich cohort. NRH had to be diagnosed by liver biopsy. Read More

    Limited Exercise Capacity in Patients with Systemic Sclerosis: Identifying Contributing Factors with Cardiopulmonary Exercise Testing.
    J Rheumatol 2017 Nov 1. Epub 2017 Nov 1.
    From the Service de Médecine Interne, Centre Hospitalier Universitaire (CHU) de Nice, Nice; University of Lille, U995 Lille Inflammation Research International Center (LIRIC), Lille; INSERM, U995, Lille; CHU Lille, Département de Médecine Interne et Immunologie Clinique, Lille; Centre national de référence maladies systémiques et auto-immunes rares (sclérodermie systémique), Lille; Service d'Explorations Fonctionnelles Respiratoires, CHU de Lille, Lille; FHU OncoAge, Côte d'Azur University, Nice, France. N. Martis, MD, MS, Service de Médecine Interne, CHU de Nice; V. Queyrel-Moranne, MD, MS, Service de Médecine Interne, CHU de Nice; D. Launay, MD, PhD, Professor of Medicine, Univ. Lille, U995, LIRIC, INSERM U995, CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre national de référence maladies systémiques et auto-immunes rares (sclérodermie systémique); R. Neviere, MD, PhD, Professor of Medicine, Service d'Explorations Fonctionnelles Respiratoires, CHU de Lille; J.G. Fuzibet, MD, MS, Professor of Medicine, Service de Médecine Interne, CHU de Nice; C.H. Marquette, MD, PhD, Professor of Medicine, FHU OncoAge, Côte d'Azur University; S. Leroy, MD, FHU OncoAge, Côte d'Azur University. Address correspondence to Dr. N. Martis, Service de Médecine Interne, CHU de Nice, 151 Route de Saint-Antoine de Ginestière, 06200 Nice, France. E-mail: Accepted for publication August 8, 2017.
    Objective: Exercise limitation in patients with systemic sclerosis (SSc) is often multifactorial and related to complications such as interstitial lung disease (ILD), pulmonary vasculopathy (PV), left ventricular dysfunction (LVD), and/or peripheral/muscular limitation (PML). We hypothesized that cardiopulmonary exercise testing (CPET) could not only suggest and rank competing etiologies, but also highlight peripheral impairment.

    Methods: Clinical, resting pulmonary function testing, and CPET data from patients with SSc referred for exercise limitation between October 2009 and November 2015 were retrospectively analyzed in this bi-center study. Read More

    Pomalidomide in Patients with Interstitial Lung Disease due to Systemic Sclerosis: A Phase II, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study.
    J Rheumatol 2017 Nov 1. Epub 2017 Nov 1.
    From the Robert Wood Johnson (RWJ) Medical School Scleroderma Program, New Brunswick; Celgene Corp., Summit, New Jersey; Department of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; David Geffen School of Medicine at the University of California at Los Angeles (UCLA), Los Angeles, California; Georgetown University Medical Center, Washington, DC, USA; Centre for Rheumatology and Connective Tissue Disease, London, UK; The Queen Elizabeth Hospital and University of Adelaide, Adelaide, Australia; Research Rheumatology Institute n.a. V.A. Nassonova, Moscow, Russia; Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany. Funded by Celgene Corp. V.M. Hsu, MD, RWJ Medical School Scleroderma Program; C.P. Denton, MBBS, MRCP, Centre for Rheumatology and Connective Tissue Disease; R.T. Domsic, MD, MPH, Department of Rheumatology, University of Pittsburgh; D.E. Furst, MD, David Geffen School of Medicine at UCLA; M. Rischmueller, MD, FRACP, The Queen Elizabeth Hospital and University of Adelaide; M. Stanislav, MD, PhD, DMSc, Research Rheumatology Institute n.a. V.A. Nassonova; V.D. Steen, MD, Georgetown University Medical Center; J.H. Distler, MD, Department of Internal Medicine 3, University of Erlangen-Nuremberg; S. Korish, MD, Celgene Corp.; A. Cooper, Celgene Corp.; S. Choi, PhD, Celgene Corp.; P.H. Schafer, PhD, Celgene Corp.; G. Horan, PhD, Celgene Corp.; D.R. Hough, MD, Celgene Corp. Address correspondence to Dr. V.M. Hsu, RWJ Medical School Scleroderma Program, 51 French St., P.O. Box 19, New Brunswick, New Jersey 08903, USA. E-mail: Accepted for publication August 9, 2017.
    Objective: To evaluate the safety and efficacy of pomalidomide (POM) on forced vital capacity (FVC), modified Rodnan skin score (mRSS), and gastrointestinal (GI) symptomatology over 52 weeks of treatment in patients with interstitial lung disease due to systemic sclerosis (SSc).

    Methods: Twenty-three adult patients diagnosed with SSc were randomized 1:1 POM:placebo (PBO).

    Results: Mean change at Week 52 from baseline in predicted FVC% -5. Read More

    The Measurement of the Endothelial Glycocalyx as a New Biomarker of Endothelial Derangement in Systemic Sclerosis: A Challenge for the Future.
    J Rheumatol 2017 Nov 1;44(11):1572-1574. Epub 2017 Nov 1.
    Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology, Azienda Ospedaliero-Universitaria Careggi (AOUC), Florence, Italy.

    Transforming growth factor-b signaling in systemic sclerosis.
    J Biomed Res 2017 Nov 1. Epub 2017 Nov 1.
    Department of Physiology & Pharmacology, University of Georgia, Athens, GA 30602, USA.
    Systemic sclerosis (SSc) is a complex, multiorgan autoimmune disease of unknown etiology. Manifestation of the disease results from an interaction of three key pathologic features including irregularities of the antigen-specific immune system and the non-specific immune system, resulting in autoantibody production; vascular endothelial activation of small blood vessels; and tissue fibrosis as a result of fibroblast dysfunction. Given the heterogeneity of clinical presentation of the disease, a lack of universal models has impeded adequate testing of potential therapies for SSc. Read More

    Productivity Losses and Costs in the Less-Common Systemic Autoimmune Rheumatic Diseases.
    Curr Rheumatol Rep 2017 Oct 30;19(11):72. Epub 2017 Oct 30.
    Arthritis Research Canada, Richmond, BC, Canada.
    Purpose Of Review: We synthesised the literature on productivity losses and costs in the less-common systemic autoimmune rheumatic diseases: Sjogren's syndrome (SjS), systemic sclerosis (SSc), poly/dermatomyositis (PM/DM), and systemic vasculitides (SV).

    Recent Findings: Of 29 studies located, 12 were published 2012 onwards (SSc = 6, SjS = 2, PM/DM = 2, SV = 2). In these, 25% of PM/DM, and 21-26% of SV, were work disabled, 22% of SSc stopped work within 3 years of diagnosis, and annual costs of absenteeism in SSc averaged $12,024 2017 USD. Read More

    Association between cortisol levels and pain threshold in systemic sclerosis and major depression.
    Rheumatol Int 2017 Oct 30. Epub 2017 Oct 30.
    Division of Rheumatology, Department of Medicine, University of Louisville, Kentucky, USA.
    Pain perception and threshold show complex interactions with the inflammatory, psychiatric and neuroendocrine stimuli. This study aims to test whether lower serum cortisol levels are associated with lower pain thresholds and higher degree of depression in systemic sclerosis (SSc) and major depression with atypical features (MD-AF) patients compared to controls. 180 female subjects (SSc = 60, MD-AF = 60, healthy controls = 60) participated in this observational, cross-sectional, parallel group study. Read More

    Breastfeeding and autoimmunity: Programing health from the beginning.
    Am J Reprod Immunol 2017 Oct 30. Epub 2017 Oct 30.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
    Breast milk is not only a completely adapted nutrition source for the newborn but also an impressive array of immune-active molecules that afford protection against infections and shape mucosal immune responses. Decisive imprinting events might be modulated during the first months of life with potential health long-term effects, enhancing the importance of breastfeeding as a major influence on the immune system correct development and modifying disease susceptibility. The aim of this review was to clarify the link between breastfeeding and autoimmune diseases, inquiring the related mechanisms, based on data available in the literature. Read More

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