3,214 results match your criteria Systemic Lupus Erythematosus and Pregnancy


Prediction of fetal loss in Chinese pregnant patients with systemic lupus erythematosus: a retrospective cohort study.

BMJ Open 2019 Feb 11;9(2):e023849. Epub 2019 Feb 11.

Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objective: To develop a predictive model for fetal loss in women with systemic lupus erythematosus (SLE).

Design: A retrospective cohort study.

Setting: Data were collected in a tertiary medical centre, located in Shanghai, China, from September 2011 to May 2017. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023849DOI Listing
February 2019
1 Read

Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL/lpr mice treated with lipopolysaccharide.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences, Sendai, 980-8578, Japan; Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan. Electronic address:

Systemic lupus erythematosus (SLE) increases the risk of preterm birth and preeclampsia (PE). The flares of SLE during pregnancy or after delivery are also problematic. We have previously demonstrated that nicotinamide (NAM), a non-teratogenic amide of vitamin B3, reduces inflammation and oxidative stress and improves PE-like phenotype and pregnancy outcomes in the mouse models of PE. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.01.110DOI Listing
February 2019
1 Read

[Lupus nephritis].

Nephrol Ther 2019 Feb 7. Epub 2019 Feb 7.

Service de néphrologie, hôpital Bichat, 46, rue Henri-Huchard, 75877 Paris cedex 18, France; Université Paris Diderot, 5, rue Thomas-Mann, 75013 Paris, France; Inserm U1149, Département hospitalo-universitaire (DHU) Fibrosis-Inflammation-Remodeling (FIRE), 16, rue Henri Huchard, 75890 Paris cedex 18, France. Electronic address:

Systemic lupus erythematosus is the most characteristic of auto-immune disorders that can lead to tissue damage in many organs, including kidney. Lupus nephritis occurs in 10 to 40% of lupus patients. Its clinical hallmark is the appearance of a proteinuria as soon as a 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255183065
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http://dx.doi.org/10.1016/j.nephro.2018.11.003DOI Listing
February 2019
2 Reads

10 most important contemporary challenges in the management of SLE.

Lupus Sci Med 2019 10;6(1):e000303. Epub 2019 Jan 10.

Service de rhumatologie, Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France.

From a 1-year survival of less than 50% before the discovery of glucocorticoids to over 90% at 10 years in most dedicated centres, the spectrum of SLE has profoundly evolved. Despite this improvement, several major challenges currently remain. The aim of this review is to analyse what are, according to us, the 10 most important contemporary challenges in the management of SLE. Read More

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http://lupus.bmj.com/lookup/doi/10.1136/lupus-2018-000303
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http://dx.doi.org/10.1136/lupus-2018-000303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340557PMC
January 2019
4 Reads

Maternal and Fetal Outcomes in Iranian Patients with Systemic Lupus Erythematosus: A Five Year Retrospective Study of 60 Pregnancies.

Curr Rheumatol Rev 2019 Jan 25. Epub 2019 Jan 25.

Department of OB and GYN, Shiraz University of Medical Sciences. Iran.

Background: As a multisystem autoimmune disease, systemic lupus erythematosus (SLE) mainly affects women during reproductive age. This retrospective study was designed to investigate the fetal and maternal outcomes of Iranian women with SLE.

Methods: Clinical and laboratory records of 60 pregnancies in 55 SLE patients who attended Hafez hospital, a tertiary referral center for high risk pregnancies and SLE patients affiliated with Shiraz University of Medical Science, were reviewed during April 2012 and March 2016. Read More

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http://dx.doi.org/10.2174/1573397115666190125162248DOI Listing
January 2019
2 Reads

Systemic lupus erythematosus in pregnancy: high risk, high reward.

Curr Opin Obstet Gynecol 2019 Jan 22. Epub 2019 Jan 22.

Stanford University, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Stanford, California, USA.

Purpose Of Review: The aim of this study was to describe risks of systemic lupus erythematosus (SLE) in pregnancy and the importance of preconception counselling, medication optimization and close surveillance.

Recent Findings: Advances in care for pregnant patients with SLE have led to improved obstetric outcomes, but maternal and foetal risks continue to be elevated. Conception during periods of disease quiescence and continuation of most medications decrease adverse pregnancy outcomes. Read More

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http://dx.doi.org/10.1097/GCO.0000000000000528DOI Listing
January 2019
3 Reads

Utility of neutrophil-to-lymphocyte ratio plus C-reactive protein for infection in systemic lupus erythematosus.

Lupus 2019 Jan 20:961203318821176. Epub 2019 Jan 20.

3 Facultad de Medicina, División de Posgrado, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Objective: To analyze the utility of neutrophil-to-lymphocyte ratio (NLR) plus C-reactive protein (CRP) to differentiate between infection and active disease in patients with SLE.

Methods: A cross-sectional study of a cohort of patients with SLE was carried out. Blood samples from four groups (patients without infection or active disease, patients with infection, patients with active disease, and patients with both infection and active disease) before therapeutic interventions were analyzed. Read More

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http://dx.doi.org/10.1177/0961203318821176DOI Listing
January 2019
2 Reads

[Etiologies and risk factors for young people with intracerebral hemorrhage].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Nov;43(11):1246-1250

Department of Geriatrics Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To determine the etiologies and risk factors of intracerebral hemorrhage in young people.
 Methods: A total of 401 young patients with intracerebral hemorrhage were enrolled, and they were assigned into a 20-29 , a 30-39, and a 40-45 age group. The differences of various etiologies and risk factors among the three groups were analyzed. Read More

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http://www.csumed.org/xbwk/CN/10.11817/j.issn.1672-7347.2018
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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.11.013DOI Listing
November 2018
4 Reads

Prolactin, autoimmunity, and motherhood: when should women avoid breastfeeding?

Clin Rheumatol 2019 Jan 11. Epub 2019 Jan 11.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv University, 5265601, Tel Hashomer, Israel.

The sexual dimorphic prevalence of autoimmunity represents one of the most alluring observations among the mosaic of autoimmunity. Sex hormones are believed to be a mainstay of this asymmetry. The greater prevalence of autoimmunity among fertile women, disease onset/relapses during pregnancy, and postpartum are some of the points that support this theory. Read More

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http://link.springer.com/10.1007/s10067-018-04415-y
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http://dx.doi.org/10.1007/s10067-018-04415-yDOI Listing
January 2019
9 Reads

Mother-child histocompatibility and risk of rheumatoid arthritis and systemic lupus erythematosus among mothers.

Genes Immun 2019 Jan 12. Epub 2019 Jan 12.

Genetic Epidemiology and Genomics Lab, Division of Epidemiology, School of Public Health, University of California Berkeley, 324 Stanley Hall, Berkeley, CA, 94720-3220, USA.

The study objective was to test the hypothesis that having histocompatible children increases the risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), possibly by contributing to the persistence of fetal cells acquired during pregnancy. We conducted a case control study using data from the UC San Francisco Mother Child Immunogenetic Study and studies at the Inova Translational Medicine Institute. We imputed human leukocyte antigen (HLA) alleles and minor histocompatibility antigens (mHags). Read More

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http://www.nature.com/articles/s41435-018-0055-7
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http://dx.doi.org/10.1038/s41435-018-0055-7DOI Listing
January 2019
15 Reads
2.913 Impact Factor

Cerebral Venous Sinus Thrombosis in Systemic Lupus Erythematosus.

Acta Med Indones 2018 Oct;50(4):343-345

Department of Internal Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

A 38-year-old woman presented with general weakness and vaginal bleeding. One month prior, she had been diagnosed with Evans syndrome (haemolytic anemia with positive Coombs test and thrombocytopenia) and was given oral steroid as maintenance therapy. Her serology examination was negative for hepatitis B, hepatitis C, and human immunodeficiency virus (HIV). Read More

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October 2018
9 Reads

17-β-estradiol enhances neutrophil extracellular trap formation by interaction with estrogen membrane receptor.

Arch Biochem Biophys 2018 Dec 24;663:64-70. Epub 2018 Dec 24.

Department of Biochemistry, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3, Minamitamagaki, Suzuka-city, Mie, 513-8670, Japan. Electronic address:

Cell death-associated neutrophil extracellular trap formation (NETosis) occurs during various autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, as well as during gestation. Although increasing estrogen concentrations associated with pregnancy might induce NETosis via nuclear estrogen receptor (ERα/ERβ), little is known about the mechanisms associated with estrogen-induced NETosis. Here, we investigated the effects of estrogen (17-β-estradiol; E2) on NETosis, focusing on mechanisms associated with estrogen membrane receptor (GPR30) in neutrophil-like HL-60 cells. Read More

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http://dx.doi.org/10.1016/j.abb.2018.12.028DOI Listing
December 2018
2 Reads

Human Chorionic Gonadotropin Influences Systemic Autoimmune Responses.

Front Endocrinol (Lausanne) 2018 6;9:742. Epub 2018 Dec 6.

Immunoendocrinology Lab, National Institute of Immunology, New Delhi, India.

Immunopathological outcomes in Systemic Lupus Erythematosus (SLE; or lupus) are believed to be autoantibody-mediated. Conditions which promote a Th2 skew (such as pregnancy) should encourage antibody production, worsening antibody-mediated diseases while ameliorating Th1/Th17-mediated diseases. Although an increased propensity toward autoreactivity can be observed in pregnant lupus patients and in pregnant lupus-prone mice, whether a unique human pregnancy-specific factor can contribute to such effects is unknown. Read More

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http://dx.doi.org/10.3389/fendo.2018.00742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291461PMC
December 2018
2 Reads

Disease activity assessment of rheumatic diseases during pregnancy: a comprehensive review of indices used in clinical studies.

Autoimmun Rev 2019 Feb 18;18(2):164-176. Epub 2018 Dec 18.

Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy.

Pregnancy requires a special management in women with inflammatory rheumatic diseases (RDs), with the aim of controlling maternal disease activity and avoiding fetal complications. Despite the heterogeneous course of RDs during pregnancy, their impact on pregnancy largely relates to the extent of active inflammation at the time of conception. Therefore, accurate evaluation of disease activity is crucial for the best management of pregnant patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15689972183028
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http://dx.doi.org/10.1016/j.autrev.2018.08.008DOI Listing
February 2019
7 Reads

Clinical usefulness of serum levels of soluble fms-like tyrosine kinase 1/placental growth factor ratio to rule out preeclampsia in women with new-onset lupus nephritis during pregnancy.

CEN Case Rep 2018 Dec 18. Epub 2018 Dec 18.

Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, 329-0498, Japan.

Measurement of the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio may be clinically useful to discriminate systemic lupus erythematosus (SLE) from preeclampsia. Here, we present a pregnant woman with new-onset SLE with hypertension, with the measurement of the sFlt-1/PlGF ratio during pregnancy. A 31-year-old Japanese nulliparous woman, who had been diagnosed with idiopathic thrombocytopenic purpura at 10 years, had a systolic blood pressure of 120 mmHg and was negative for proteinuria at 12 weeks. Read More

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http://dx.doi.org/10.1007/s13730-018-0373-7DOI Listing
December 2018
3 Reads

Postpartum flare up of systemic lupus erythematosus: Pulmonary diffused alveolar hemorrhage.

Taiwan J Obstet Gynecol 2018 Dec;57(6):906-907

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.tjog.2018.10.027DOI Listing
December 2018

The Differences Between Childhood and Adult Onset Antiphospholipid Syndrome.

Front Pediatr 2018 27;6:362. Epub 2018 Nov 27.

Department of Rheumatology, University College London, London, United Kingdom.

Antiphospholipid syndrome (APS) is a rare autoimmune disease of unknown etiology that represents a leading cause of acquired thromboembolism and recurrent miscarriage. It is characterized by the persistent elevated presence of pathogenic antiphospholipid auto-antibodies directed against cardiolipin, ß2-glycoprotein-I, and/or a positive lupus anticoagulant test. As with many autoimmune disorders, the pathogenesis of APS is believed to be the result of a complex interaction between environmental triggers and genetic predisposition. Read More

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http://dx.doi.org/10.3389/fped.2018.00362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277799PMC
November 2018
1 Read

Presence of Immune Complexes of IgG/IgM Bound to B2-glycoprotein I Is Associated With Non-criteria Clinical Manifestations in Patients With Antiphospholipid Syndrome.

Front Immunol 2018 20;9:2644. Epub 2018 Nov 20.

Immunology Department, Hospital 12 de Octubre, Madrid, Spain.

Antiphospholipid syndrome (APS) is an acquired autoimmune disorder defined by the presence of both clinical (thromboembolic events or pregnancy morbidity) and laboratory (antiphospholipid antibodies, aPL) manifestations. Despite their importance, several clinical manifestations strongly associated with APS such as livedo reticularis (LR), thrombocytopenia, sicca-ophthalmic(sicca), heart, or neurological manifestations are not included in the APS clinical classification criteria. Circulating immune complexes (CIC) formed by Beta-2-glycoprotein I (B2GPI) and aPL (B2-CIC) have been described and their presence has been related with thrombotic events. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256181PMC
November 2018
11 Reads

Provider perceptions on the management of lupus during pregnancy: barriers to improved care.

Lupus 2018 Dec 6:961203318815594. Epub 2018 Dec 6.

3 Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA; Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA; Duke-Margolis Center for Health Policy, Duke University, Durham, North Carolina, USA.

Background: More than half of pregnancies in women with systemic lupus erythematosus (lupus) result in adverse outcomes for the mother or the fetus. We sought to identify aspects of current rheumatologic care that could be improved to decrease the frequency of poor outcomes.

Methods: Focus groups with clinical rheumatologists, based on the PRECEDE/PROCEED framework, identified factors that influenced care. Read More

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http://dx.doi.org/10.1177/0961203318815594DOI Listing
December 2018
1 Read

TTP: long-term outcomes following recovery.

Authors:
James N George

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):548-552

Hematology-Oncology Section, Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Although risk for relapse may be the greatest concern following recovery from acquired, autoimmune thrombotic thrombocytopenic purpura (TTP), there are multiple other major health issues that must be recognized and appropriately addressed. Depression may be the most common disorder following recovery from TTP and may be the most important issue for the patient's quality of life. Severe or moderate depression has occurred in 44% of Oklahoma Registry patients. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246011PMC
November 2018
1 Read

Autoimmune disorders but not heparin are associated with cell-free fetal DNA test failure.

J Transl Med 2018 Dec 3;16(1):335. Epub 2018 Dec 3.

Service de Gynécologie-Obstétrique, AP-HP, Hôpital Antoine Béclère, Université Paris Sud, 154 rue de la Porte de Trivaux, 92140, Clamart, France.

Background: Recent studies have suggested a possible association between heparin treatment at the time of cell-free DNA (cfDNA) testing and a non-reportable result. However, these studies lack of proper methodology and had a low level of proof to firmly incriminate heparin. Our objective was to investigate further the relationship between heparin treatment and cfDNA test results. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-018-1705-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276207PMC
December 2018
17 Reads

Connective Tissue Disorders in Pregnancy.

Neurol Clin 2019 Feb;37(1):121-129

Department of Neurology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Department of Neurology, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

Connective tissue disorders are now understood to include autoimmune and genetic diseases affecting organs, blood vessels, and surrounding fascia. Many of these diseases predominantly affect women in childbearing years and are associated with neurologic complications. Pregnancy can affect disease activity (such as flares of systemic lupus erythematosus), and the diseases can affect pregnancy outcome (such as increased risk of preterm labor). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338619183125
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http://dx.doi.org/10.1016/j.ncl.2018.09.006DOI Listing
February 2019
12 Reads

Contraception for Adolescents with Medically Complex Conditions.

Authors:
Linda Carmine

Curr Probl Pediatr Adolesc Health Care 2018 Dec 19;48(12):345-357. Epub 2018 Nov 19.

Division of Adolescent Medicine, Cohen Children's Medical Center, Northwell Health, 410 Lakeville Road, Suite 108, New Hyde Park, NY 11042, United States; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United States. Electronic address:

Both the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) have developed, published, and updated evidence-based guidelines to support medical providers in the provision of contraceptives to patients with specific medical conditions or characteristics. The goal of these guidelines is to provide recommendations on the safe use of contraceptives with the goal of removing unnecessary medical barriers to access and use of contraceptives, thus decreasing the number of unintended pregnancies. Many medical conditions increase a patient's risk of venous thromboembolism; a risk that may also be increased with specific contraceptives. Read More

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http://dx.doi.org/10.1016/j.cppeds.2018.11.004DOI Listing
December 2018
18 Reads

Update on Lupus Nephritis for GPs.

Authors:
M McClure R Jones

Lupus 2018 10;27(1_suppl):11-14

Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge.

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http://dx.doi.org/10.1177/0961203318801687DOI Listing
October 2018
1 Read

Management of pregnancy in systemic lupus erythematosus: What a GP should know.

Authors:
N Jordan

Lupus 2018 10;27(1_suppl):40-43

Rheumatology Department, Addenbrookes Hospital, Cambridge, UK and The London Lupus Centre, London Bridge Hospital, London, UK.

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http://dx.doi.org/10.1177/0961203318801746DOI Listing
October 2018
2 Reads

Risk of Ocular Anomalies in Children Exposed in Utero to Antimalarials: A Systematic Literature Review.

Arthritis Care Res (Hoboken) 2018 Nov 12. Epub 2018 Nov 12.

Division of Rheumatology, McGill University Health Centre, Montreal, Canada, H3G 1A4.

Objective: To determine if SLE offspring exposed in utero to antimalarials have an increased risk of ocular anomalies during childhood versus unexposed SLE offspring.

Methods: We systematically performed searches of PubMed, Embase, and Web of Science databases for original human data on fetal and/or child ocular outcomes following exposure to antimalarials during pregnancy and/or lactation, from their inception until March 2017.

Results: 10 cohort studies and 2 randomized controlled trials, ranging in size from 6 to 444 exposed infants studied, and 3 case reports met the inclusion criteria for our systematic review. Read More

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http://dx.doi.org/10.1002/acr.23808DOI Listing
November 2018
1 Read

Two case reports of neonatal autoantibody-associated congenital heart block.

Medicine (Baltimore) 2018 Nov;97(45):e13185

Department of Pediatrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Rationale: Neonatal lupus erythematosus (NLE) is an infrequent disease caused by transplacental maternal autoantibodies. The most common effects of NLE include cutaneous involvement and congenital heart block (CHB), although it might involve multiple organs, such as the liver, lungs, blood, and nervous or digestive systems. Izmirly PM1 and Tonello et al recently reported cutaneous manifestations of neonatal lupus and risk of subsequent CHB. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811090-0007
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http://dx.doi.org/10.1097/MD.0000000000013185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250523PMC
November 2018
17 Reads

Zonal cortical scarring and tubular thyroidization in kidney biopsies of patients with SLE-histologic indicator for antiphospholipid antibodies.

Lupus 2018 Dec 7;27(14):2236-2244. Epub 2018 Nov 7.

2 Department of Pathology, Division of Renal and Transplant Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Antiphospholipid antibody syndrome (APS) is an acquired prothrombotic autoimmune disease caused by the presence of antibodies against anionic phospholipids or plasma proteins bound to phospholipids on cell membranes. It can be a primary disease or secondary to other autoimmune diseases, most commonly systemic lupus erythematosus (SLE). Laboratory testing for antiphospholipid antibodies (aPL) may be only transiently positive, so APS could be missed until a catastrophic thrombotic episode or pregnancy morbidity occurs. Read More

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http://dx.doi.org/10.1177/0961203318809177DOI Listing
December 2018
8 Reads

Intrauterine fetal deaths related to antiphospholipid syndrome: a descriptive study of 65 women.

Arthritis Res Ther 2018 Nov 6;20(1):249. Epub 2018 Nov 6.

AP-HP, Cochin Hospital, Internal Medicine Department, Centre de référence maladies auto-immunes et systémiques rares d'île de France, 27 Rue du Faubourg Saint Jacques, 75014, Paris, France.

Objective: Although one of the three obstetric manifestations of antiphospholipid syndrome (APS) is intrauterine fetal death (IUFD), little is known about it in this context. We report the first large series of patients with APS and IUFD.

Methods: We retrospectively analyzed the history and clinical data of women at four French hospitals. Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1745-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235231PMC
November 2018
6 Reads

Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection.

J Pharm Sci 2019 Jan 3;108(1):661-673. Epub 2018 Nov 3.

Aston Health Research Group, Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK; Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK. Electronic address:

The insidious nature of Zika virus (ZIKV) infections can have a devastating consequence for fetal development. Recent reports have highlighted that chloroquine (CQ) is capable of inhibiting ZIKV endocytosis in brain cells. We applied pharmacokinetic modeling to develop a predictive model for CQ exposure to identify an optimal maternal/fetal dosing regimen to prevent ZIKV endocytosis in brain cells. Read More

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http://dx.doi.org/10.1016/j.xphs.2018.10.056DOI Listing
January 2019
2 Reads

Changes in the blood level, efficacy, and safety of tacrolimus in pregnancy and the lactation period in patients with systemic lupus erythematosus.

Lupus 2018 Dec 4;27(14):2245-2252. Epub 2018 Nov 4.

1 Department of Internal Medicine (IV), Osaka Medical College, Osaka, Japan.

Objectives: We investigated the efficacy and safety of tacrolimus (TAC) by monitoring its serum concentration for mothers and infants in pregnant patients with systemic lupus erythematosus (SLE).

Methods: We measured trough concentrations of TAC in 25 pregnant patients with SLE to assess influence of TAC on the disease activity. Additionally, we measured the concentrations of TAC in umbilical arterial blood, breast milk, and breastfed infants to investigate the safety of TAC for the mothers and infants. Read More

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http://dx.doi.org/10.1177/0961203318809178DOI Listing
December 2018
8 Reads

Obstetric antiphospholipid syndrome.

Lupus Sci Med 2018 25;5(1):e000197. Epub 2018 Sep 25.

Unit of Rheumatology, Department of Medicine, Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

The present clinical and laboratory classification criteria for antiphospholipid syndrome (APS) were established in Sydney, Australia, in 2006. In this review, we focus on the obstetric subset of APS (OAPS), defined by persistent positivity for antiphospholipid antibodies together with either early recurrent pregnancy loss, early fetal death, stillbirth or premature birth <34 gestational weeks due to pre-eclampsia, eclampsia and placental insufficiency. It is important to diagnose these cases since most women suffering from OAPS can, when given appropriate treatment, have successful pregnancies. Read More

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http://dx.doi.org/10.1136/lupus-2016-000197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195166PMC
September 2018
18 Reads

Systemic Lupus Erythematosus and Pregnancy: A Single-Center Observational Study of 69 Pregnancies.

Rev Bras Ginecol Obstet 2018 Oct 23;40(10):587-592. Epub 2018 Oct 23.

Department of Internal Medicine, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.

Objective:  To evaluate the effects of pregnancy in systemic lupus erythematosus (SLE) patients.

Methods:  The present article is a retrospective cohort study. Data were collected from medical records of pregnant women with SLE from January 2002 to December 2012 at Universidade Estadual de Campinas, in the city of Campinas, state of São Paulo, Brazil. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1672136
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http://dx.doi.org/10.1055/s-0038-1672136DOI Listing
October 2018
9 Reads

Evans syndrome: clinical perspectives, biological insights and treatment modalities.

J Blood Med 2018 10;9:171-184. Epub 2018 Oct 10.

Department of Hematology, Internal Medicine Division, Dr José E González University Hospital, School of Medicine of the Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México,

Evans syndrome (ES) is a rare and chronic autoimmune disease characterized by autoimmune hemolytic anemia and immune thrombocytopenic purpura with a positive direct anti-human globulin test. It is classified as primary and secondary, with the frequency in patients with autoimmune hemolytic anemia being 37%-73%. It predominates in children, mainly due to primary immunodeficiencies or autoimmune lymphoproliferative syndrome. Read More

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https://www.dovepress.com/evans-syndrome-clinical-perspectiv
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http://dx.doi.org/10.2147/JBM.S176144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190623PMC
October 2018
13 Reads

[A case of systemic lupus erythematosus in pregnancy complicated by pulmonary hypertension].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Oct;50(5):928-931

Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.

To investigate the pathophysiology, screening, diagnosis and treatment of the systemic lupus erythematosus (SLE) in pregnancy complicated with pulmonary hypertension. Retrospective analysis was made of one case of SLE in pregnancy complicated with pulmonary hypertension in Peking University Third Hospital. Literature was reviewed to investigate the pathophysiology, screening, diagnosis and treatment of the SLE in pregnancy complicated with pulmonary hypertension. Read More

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October 2018
13 Reads

Neonatal punctate calcifications associated with maternal mixed connective tissue disorder (MCTD).

BMJ Case Rep 2018 Oct 12;2018. Epub 2018 Oct 12.

Neonatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Chondrodysplasia punctate (CDP) is a rare group of disorders with both genetic and non-genetic underlying aetiologies. The genetic causes associated with CDP include peroxisomal disorders, type two mucolipidosis, type 3 mucopolysaccharidosis, GM1 gangliosidosis and chromosomal disorders. Peroxisomal disorders include deficiency of dihydroxyacetone phosphate acyltransferase, encoded by GNPAT, deficiency of the peroxisomal enzyme alkyl-dihydroxyacetone phosphate synthase, encoded by AGPS and Zellweger syndrome. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2017-22337
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http://dx.doi.org/10.1136/bcr-2017-223373DOI Listing
October 2018
12 Reads

Effect of in utero hydroxychloroquine exposure on the development of cutaneous neonatal lupus erythematosus.

Ann Rheum Dis 2018 Dec 8;77(12):1742-1749. Epub 2018 Oct 8.

Division of Rheumatology, New York University School of Medicine, New York City, New York, USA.

Objective: Cutaneous neonatal lupus (cNL) occurs in possibly 5%-16% of anti-Ro±anti-La antibody-exposed infants. Data suggest in utero exposure to hydroxychloroquine (HCQ) may prevent cardiac NL. The aim was to assess whether in utero exposure to HCQ decreases the risk of cNL and/or delays onset. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-213718DOI Listing
December 2018
4 Reads

Hydroxychloroquine Levels throughout Pregnancies Complicated by Rheumatic Disease: Implications for Maternal and Neonatal Outcomes.

J Rheumatol 2019 Jan 1;46(1):57-63. Epub 2018 Oct 1.

From the departments of Internal Medicine and Pediatrics, Duke University, and Duke Clinical Research Institute, Durham, North Carolina; Department of Pediatrics, Children's Hospital of Chicago, Chicago, Illinois, USA.

Objective: Pregnancies in women with active rheumatic disease often result in poor neonatal outcomes. Hydroxychloroquine (HCQ) reduces disease activity and flares; however, pregnancy causes significant physiologic changes that may alter HCQ levels and lead to therapeutic failure. Therefore, our objective was to evaluate HCQ concentrations during pregnancy and relate levels to outcomes. Read More

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http://dx.doi.org/10.3899/jrheum.180158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314916PMC
January 2019
8 Reads

Thrombotic Microangiopathies with Rheumatologic Involvement.

Rheum Dis Clin North Am 2018 11 7;44(4):635-649. Epub 2018 Sep 7.

Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, 2150 Pennsylvania Avenue, Washington, DC 20037, USA. Electronic address:

Thrombotic microangiopathies are heterogeneous disorders characterized by microangiopathic hemolytic anemia with thrombocytopenia and renal injury. There are a variety of causes, including metabolic disorders, infections, medications, complement disorders, pregnancy, malignancy, and autoimmune disorders. This review focuses on renal thrombotic microangiopathy in the setting of rheumatologic diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0889857X183006
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http://dx.doi.org/10.1016/j.rdc.2018.06.010DOI Listing
November 2018
31 Reads

Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study.

J Immunol Res 2018 3;2018:2413637. Epub 2018 Sep 3.

Department of Rheumatology, The First Affiliated Hospital of Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou 510080, China.

Objective: To investigate the fetal and maternal outcomes as well as predictors of APOs in women with SLE who conceived when the disease was stable, the so-called "planned pregnancy." . A retrospective multicenter study of 243 patients with SLE who underwent a planned pregnancy was performed. Read More

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http://dx.doi.org/10.1155/2018/2413637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140277PMC
December 2018
9 Reads

Does left ventricular hypertrophy by electrocardiogram predict adverse outcomes in pregnancies with chronic hypertension?

J Matern Fetal Neonatal Med 2018 Oct 29:1-5. Epub 2018 Oct 29.

a Department of Obstetrics and Gynecology , University of Tennessee Health Science Center , Memphis , TN , USA.

Objectives: The American College of Obstetricians and Gynecologists Task Force on Hypertension in Pregnancy recommends assessing left ventricular function with echocardiogram or electrocardiogram (ECG) in women with severe hypertension of long duration. We aim to compare the rates of superimposed preeclampsia (SIP) and other obstetrical outcomes in pregnancies with chronic hypertension (CHTN) and left ventricular hypertrophy (LVH) by ECG criteria with mothers without LVH.

Study Design: After IRB approval, we performed a retrospective chart review from January 2015 to December 2016. Read More

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http://dx.doi.org/10.1080/14767058.2018.1524457DOI Listing
October 2018
2 Reads

Antiphospholipid syndrome - an update.

Authors:
Birgit Linnemann

Vasa 2018 10 12;47(6):451-464. Epub 2018 Sep 12.

1 Division of Angiology, East Bavarian Center of Vascular Medicine, University Hospital Regensburg, Regensburg, Germany.

Antiphospholipid syndrome (APS) is an autoantibody-mediated acquired thrombophilia. It is characterized by the presence of antiphospholipid antibodies (APL) that are directed against phospholipid-binding plasma proteins, such as beta-2-glycoprotein I (b2GPI). Its main manifestations are recurrent vascular thromboses (so-called "thrombotic APS") and pregnancy complications ("obstetric APS"). Read More

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http://dx.doi.org/10.1024/0301-1526/a000723DOI Listing
October 2018
16 Reads

[MANAGEMENT OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN THE PREPREGNANCY AND ANTENATAL PERIODS: CHALLENGES AND SOLUTIONS (REVIEW)].

Georgian Med News 2018 Jul-Aug(280-281):54-61

SE "Dnepropetrovsk Medical Academy of Health Ministry of Ukraine".

Systemic lupus erythematosus (SLE) is a rare, multi-systemic chronic autoimmune disease characterized by hyperproduction of organ-specific autoantibodies to various components of the cell nucleus with the development of immuno-inflammatory damage of tissues and internal organs, predominantly affecting women, particularly those of childbearing age. Hence future pregnancy is one of the key issues of the modern rheumatology. The management of the SLE patient should include an effective risk assessment of the future pregnancy and stratification followed by an individualized antenatal care program. Read More

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December 2018
1 Read

[Adolescent rheumatism : The same but different].

Authors:
Sabine Adler

Z Rheumatol 2018 Oct;77(8):694-702

Abteilung für Rheumatologie, Immunologie und Allergologie, Universitätsspital/Inselspital Bern, Freiburgstrasse 8, 3010, Bern, Schweiz.

Between childhood and adulthood, there often exists a difficult period of coming of age. This phase frequently represents a significant challenge for adolescents and young adults at the physical, psychological, and social level. Having trouble with adolescence itself it puts an extra weight on young people with chronic rheumatic diseases. Read More

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http://dx.doi.org/10.1007/s00393-018-0530-6DOI Listing
October 2018
3 Reads

Pharmacological Approach to Managing Childhood-Onset Systemic Lupus Erythematosus During Conception, Pregnancy and Breastfeeding.

Paediatr Drugs 2018 Dec;20(6):511-521

Division of Rheumatic Diseases, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-8884, USA.

Pediatric patients often have poor pregnancy outcomes. Systemic lupus erythematosus predominantly impacts women in their second to fourth decade of life, with childhood-onset disease being particularly aggressive. Reproductive issues are an important clinical consideration for pediatric patients with systemic lupus erythematosus (SLE), as maintaining good disease control and planning a pregnancy are important for maternal and fetal outcomes. Read More

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http://dx.doi.org/10.1007/s40272-018-0312-2DOI Listing
December 2018
2 Reads

Pregnancy and newborn outcomes after exposure to bisphosphonates: a case-control study.

Osteoporos Int 2019 Jan 31;30(1):221-229. Epub 2018 Aug 31.

Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Paris-Sud, Department of Rheumatology, Hôpital Bicêtre Université Paris-Sud, INSERM U1184, 78 rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.

We analyzed women and newborn outcome after maternal exposure to BPs. BPs have no teratogenic effect on the 36 analyzed pregnancies compared to unexposed controls matched on women underlying diseases (either systemic disease, either "bone" disease) but some outcome differed: neonatal complications rate in systemic diseases and live birth rate in bone diseases).

Introduction: The effect of bisphosphonates (BPs) during pregnancy remains unclear. Read More

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http://dx.doi.org/10.1007/s00198-018-4672-9DOI Listing
January 2019
2 Reads

All-cause hospitalizations in systemic lupus erythematosus from a single medical center in Israel.

Rheumatol Int 2018 Oct 27;38(10):1841-1846. Epub 2018 Aug 27.

Internal Medicine B, Rheumatology Unit, Assaf Harofeh Medical Center, Be'er Ya'akov, Israel.

Objective: Clinical features of systemic lupus erythematosus (SLE) have been described from different geographical regions in the world. The aim of this study was to obtain local and contemporary data on all-cause hospitalizations of SLE patients in an Israeli Medical Center.

Methods: This is a retrospective observational single-center study. Read More

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http://link.springer.com/10.1007/s00296-018-4147-5
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http://dx.doi.org/10.1007/s00296-018-4147-5DOI Listing
October 2018
20 Reads

Challenging cases in rheumatic pregnancies.

Rheumatology (Oxford) 2018 07;57(suppl_5):v18-v25

Division of Rheumatic Diseases, University of Texas Southwestern, Dallas, TX, USA.

This article describes three complicated cases in rheumatology and pregnancy. The first case elucidates the challenges in treating SLE in conjunction with pulmonary arterial hypertension, while the second case features an SLE-affected pregnancy with development of portal hypertension secondary to portal vein thrombosis related to APS. The third case is a pregnant woman with stable SLE who developed thrombotic microangiopathy caused by atypical haemolytic uraemic syndrome, and failed to improve despite multiple measures including biopsy and elective preterm delivery. Read More

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https://academic.oup.com/rheumatology/article/57/suppl_5/v18
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http://dx.doi.org/10.1093/rheumatology/key172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099127PMC
July 2018
18 Reads

Power in numbers.

Rheumatology (Oxford) 2018 07;57(suppl_5):v40-v47

Division of Rheumatology, Duke University Medical Center, Durham, NC, USA.

Collecting useful data on a sufficiently large cohort of pregnancies in women with rheumatic disease is a challenge. The original manuscripts that demonstrated the dangers of pregnancy in women with lupus were relatively small case series. As larger prospective cohorts were collected by university-based experts, however, greater safety was demonstrated and the current norms of treatment were determined. Read More

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http://dx.doi.org/10.1093/rheumatology/key111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099130PMC
July 2018
6 Reads

The prevention, screening and treatment of congenital heart block from neonatal lupus: a survey of provider practices.

Rheumatology (Oxford) 2018 07;57(suppl_5):v9-v17

Division of Rheumatology, New York University School of Medicine, NY, USA.

Objective: To survey an international sample of providers to determine their current practices for the prevention, screening, and treatment of congenital heart block (CHB) due to maternal Ro/SSA antibodies.

Methods: A survey was designed by the organizing committee of the 9th International Conference of Reproduction, Pregnancy and Rheumatic Diseases. It was sent to attendants of the conference and authors of recent publications or abstracts at ACR 2012, 2013 or 2014 on rheumatic diseases and pregnancy. Read More

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http://dx.doi.org/10.1093/rheumatology/key141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099126PMC
July 2018
26 Reads