459,791 results match your criteria Systemic Lupus Erythematosus


Advances in Delayed-Onset Muscle Soreness (DOMS): Part I: Pathogenesis and Diagnostics.

Sportverletz Sportschaden 2018 Dec 11;32(4):243-250. Epub 2018 Dec 11.

Muscle Research Center Erlangen, Interdisciplinary Center for Muscle Research, Friedrich-Alexander-University Erlangen-Nuremberg, Germany.

Delayed-onset muscle soreness (DOMS) is a type of ultrastructural muscle injury. The manifestation of DOMS is caused by eccentric or unfamiliar forms of exercise. Clinical signs include reduced force capacities, increased painful restriction of movement, stiffness, swelling, and dysfunction of adjacent joints. Read More

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December 2018

Systemic Arterial Hypertension in Childhood: A Challenge Related to the Increasing Survival of Very Low Birth Weight Preterm Infants.

Am J Perinatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Objective:  To verify the prevalence of systemic arterial hypertension (SAH) and to identify possible early predictors of SAH at ages 2 and 4 years in very low birth weight (VLBW) infants.

Study Design:  This is a prospective cohort study including inborn children with birth weight (BW) <1,500 g. Arterial blood pressure measurements were performed at 2 and 4 years. Read More

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December 2018

The Efficacy of Concurrent or Sequential Intravenous and Intratympanic Steroid for Idiopathic Sudden Sensorineural Hearing Loss.

Audiol Neurootol 2018 Dec 11;23(5):277-284. Epub 2018 Dec 11.

Department of Otorhinolaryngology - Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.

Objective: The purpose of this retrospective study was to investigate the difference in treatment outcomes for patients with idiopathic sudden sensorineural hearing loss (SSNHL) undergoing concurrent or sequential intravenous (IV) and intratympanic (IT) steroid therapies.

Methods: Patients with idiopathic SSNHL admitted to Taipei Veterans Hospital from August 2011 to August 2012 were enrolled. Patients were treated with both IV dexamethasone 5 mg b. Read More

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December 2018

In Vivo Assessment of Combined Effects of Glibenclamide and Losartan in Diabetic Rats.

Med Princ Pract 2018 Dec 10. Epub 2018 Dec 10.

Objective: Diabetic complications involve multiple pathological pathways, including hyperglycemia-induced oxidative stress and inflammation. Combination therapy is usually employed to improve treatment outcomes and to lower potential adverse effects. In this study, we evaluated the effects of antidiabetic and antihypertensive agents, glibenclamide (GLI) and losartan (LT), on diabetes-associated metabolic changes in rats. Read More

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December 2018

Curators and sojourners in learning networks: Practices for transformation.

Authors:
Julie Risien

Eval Program Plann 2018 Dec 4;73:71-79. Epub 2018 Dec 4.

Center for Research on Lifelong STEM Learning, Oregon State University, 254 Gilbert Hall, Corvallis, OR, 97331, United States. Electronic address:

Networks are a promising mechanism for creating systemic change. Studies abound, but do not examine roles and practices to reveal the processes through which networks create transformative capacity. This participatory single case study provides a framework to examine structures, roles and practices. Read More

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December 2018

Do concentrations of perfluoroalkylated acids (PFAAs) in isopods reflect concentrations in soil and songbirds? A study using a distance gradient from a fluorochemical plant.

Sci Total Environ 2018 Dec 7;657:111-123. Epub 2018 Dec 7.

Systemic Physiological and Ecotoxicologal Research (SPHERE), Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium. Electronic address:

Perfluoroalkylated acids (PFAAs) are persistent chemicals that have been detected globally in the environment and in wildlife. Although it is known that PFAAs sorb to solid matrices, little is known on PFAA concentrations in soils. PFAA pollution has often been studied in aquatic invertebrates. Read More

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December 2018

Serious Asthma Events with Mometasone Furoate Plus Formoterol Compared With Mometasone Furoate.

J Allergy Clin Immunol 2018 Dec 8. Epub 2018 Dec 8.

Asthma and Allergy Associates and Research Center, Colorado Springs, Colorado.

Background: The safety of long-acting beta agonists added to inhaled corticosteroids for the treatment of persistent asthma has been controversial.

Objective: To determine whether administering formoterol in combination with mometasone furoate increases the risk of serious asthma outcomes compared to mometasone furoate alone.

Methods: We conducted a 26-week, randomized, double-blind trial in adolescent and adult patients (≥12 years) with persistent asthma in 35 countries with the primary objective of evaluating whether mometasone furoate-formoterol increases the risk of serious asthma outcomes (adjudicated hospitalization, intubation, or death) compared to mometasone furoate alone. Read More

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December 2018

Pep-1&Borneol-bifunctionalized carmustin-loaded micelles enhance anti-glioma efficacy through tumor targeting and BBB penetratings.

J Pharm Sci 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurosurgery, School of Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, China. Electronic address:

Tumor-targeting and blood-brain barrier (BBB)-penetrating are highly desirable for the treatment of glioma. In this study, we developed Pep-1&borneol-bifunctionalized carmustin-loaded micelles (Pep-1/Bor/CMS-M) capable of targeting to IL-13 receptor-overexpressed glioma and penetrating the brain microvascular endothelial cells-associated physiologic barriers. Pep-1/Bor/CMS-M were nearly spherical particles with a diameter of 32. Read More

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December 2018
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The value of immunotherapy in head and neck cancer.

Expert Opin Biol Ther 2018 Dec 11. Epub 2018 Dec 11.

d Marlene and Stewart Greenebaum Comprehensive Cancer Center , University of Maryland School of Medicine , Baltimore , Maryland.

Introduction: Head and neck squamous cell carcinomas (HNSCC) previously had limited treatment options once patients had progressed on systemic chemotherapy. With recent advances, immunotherapy now plays an important role in the treatment of advanced disease with improved outcomes as compared to cytotoxic chemotherapy. Areas covered: This article reviews the effects of the immune system and how it influences the development and response to HNSCC therapy. Read More

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December 2018
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Contrast-enhanced ultrasonography is a feasible technique for quantifying hepatic microvascular perfusion in dogs with extrahepatic congenital portosystemic shunts.

Vet Radiol Ultrasound 2018 Dec 9. Epub 2018 Dec 9.

Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan.

Extrahepatic-congenital portosystemic shunt is a vascular anomaly that connects the portal vein to the systemic circulation and leads to a change in hepatic microvascular perfusion. However, an assessment of hepatic microvascular perfusion is limited by conventional diagnostic modalities. The aim of this prospective, exploratory study was to assess hepatic microvascular perfusion in dogs with extrahepatic-congenital portosystemic shunt using contrast-enhanced ultrasonography (CEUS) using perfluorobutane (Sonazoid ). Read More

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December 2018

Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle-aged Caucasians: the Northern Finland Birth Cohort Eye study.

Acta Ophthalmol 2018 Dec 10. Epub 2018 Dec 10.

Department of Ophthalmology, Oulu University Hospital, Oulu, Finland.

Purpose: To study the normal relationship between retinal vessel diameter (RVD) with retinal nerve fibre layer (RNFL) thickness and optic nerve head (ONH) parameters in a cohort of middle-aged Caucasians.

Methods: We investigated 3070 individuals (6140 eyes). Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured in the right eye using a semi-automated computer-assisted program. Read More

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December 2018
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Pseudozyma aphidis activates reactive oxygen species production, programmed cell death and morphological alterations in the necrotrophic fungus Botrytis cinerea.

Mol Plant Pathol 2018 Dec 10. Epub 2018 Dec 10.

Department of Plant Pathology and Microbiology, The Robert H. Smith, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 76100, Israel.

Many types of yeasts have been studied in the last few years as potential biocontrol agents against different phytopathogenic fungi. Their ability to control plant diseases is mainly through combined modes of action. Among them, antibiosis, competition for nutrients and niches, induction of systemic resistance in plants and mycoparasitism have been the most studied. Read More

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December 2018

Activation of immune receptor Rx1 triggers distinct immune-responses culminating in cell death after four hours.

Mol Plant Pathol 2018 Dec 8. Epub 2018 Dec 8.

University of Amsterdam, Molecular Plant Pathology, Amsterdam, Netherlands.

Intracellular NLR (nucleotide-binding leucine-rich repeat)-type immune receptors are a fundamental aspect of plant immune systems. As infection occurs at foci, activation of immune responses is typically non-uniform and non-synchronized, hampering the systematic dissection of their cellular effects and determining their phasing. We investigated the Potato NLR Rx1 using the CESSNA (Controlled Expression of effectors for Synchronized and Systemic NLR Activation) platform. Read More

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December 2018

IL-37 alleviates house dust mite-induced chronic allergic asthma by targeting TSLP through the NF-κB & ERK1/2 signaling pathways.

Immunol Cell Biol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pulmonary Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Institute of Respiratory Diseases of Sun Yat, Sen University, Guangzhou, China.

Interleukin (IL)-37 has been described as a negative regulator of immune responses and is critical for asthma pathogenesis, but the mechanisms behind the protective role of IL-37 against allergic asthma are less well understood. We show here that IL-37 administered intranasally (i.n. Read More

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December 2018

Combined treatment with systemic resveratrol and resveratrol preconditioned mesenchymal stem cells, maximizes antifibrotic action in diabetic cardiomyopathy.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Physiology, Faculty of Medicine, Cairo University, Giza, Egypt.

Wnt/β-catenin signaling pathway plays a crucial role in diabetic cardiomyopathy (DCM), thus we aimed at investigating the effect of one therapeutic approach with resveratrol (RSV) given systemically and combined treatment of RSV with mesenchymal stem cells (MSCs) that was either RSV-preconditioned or not on Wnt/β-catenin signaling pathway in streptozotocin-induced DCM, and to evaluate effects of RSV preconditioning on MSCs therapeutic potential. The rats were divided into control (C, n = 8), diabetic (DM, n = 8), diabetic treated with systemic RSV (DM-RSV, n = 8), diabetic treated with RSV and nonconditioned MSCs (DM-RSV-MSCs, n = 8), diabetic treated with RSV and RSV-incubated with MSCs (DM-RSV-MSCc, n = 8) and diabetic treated with RSV-conditioned MSCs (DM-MSCc, n = 8). Echocardiography (Echo) showed significant improvement of cardiac functions in all groups treated with RSV either systemic or added in culture media. Read More

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December 2018

Vectorizing agrochemicals: enhancing bioavailability via carrier-mediated transport.

Pest Manag Sci 2018 Dec 7. Epub 2018 Dec 7.

Institut de Chimie des Milieux et des Matériaux de Poitiers (IC2MP), Unité Mixte de Recherche CNRS 7285, Université de Poitiers, 4 rue Michel Brunet, TSA 51106, F-86073 Poitiers cedex 9 France.

Systemicity of agrochemicals is an advantageous property for controlling phloem sucking insects, as well as pathogens and pests not accessible to contact products. After the penetration of the cuticle, the plasma membrane constitutes the main barrier to the entry of an agrochemical into the sap flow. The current strategy for developing systemic agrochemicals is to optimize the physicochemical properties of the molecules so that they can cross the plasma membrane by simple diffusion or ion trapping mechanisms. Read More

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December 2018

HMGB1+ microparticles present in urine are hallmarks of nephritis in patients with systemic lupus erythematosus.

Eur J Immunol 2018 Dec 10. Epub 2018 Dec 10.

Grupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No 52-21, Medellín, Colombia.

Non-classical monocytes infiltrate the kidney parenchyma and participate in tissue damage in patients with lupus nephritis (LN). Circulating microparticles (MPs) seem to play critical roles in the activation of monocytes in systemic lupus erythematosus (SLE) patients. This study aims to characterize the phenotypes of MPs and monocyte subsets in LN patients and to determine their potential to discriminate between SLE patients with and without LN. Read More

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December 2018

Exosomes in chronic inflammatory skin diseases and skin tumors.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Exosomes are a type of endosome that can mediate communication between cells and the transport of cellular components such as microRNAs, mRNAs, proteins and DNA. Recently, exosomes have been under investigation for their significant roles in both healthy physiology and disease states. Herein, we review the role of exosomes in chronic inflammatory skin diseases and skin tumors, especially focusing on systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous pemphigoid and melanoma. Read More

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December 2018
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Transforming Weakness into Strength: Photothermal-Therapy-Induced Inflammation Enhanced Cytopharmaceutical Chemotherapy as a Combination Anticancer Treatment.

Adv Mater 2018 Dec 9:e1805936. Epub 2018 Dec 9.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing, 210009, China.

A new synergistic treatment that combines photothermal therapy (PTT) and inflammation-mediated active targeting (IMAT) chemotherapy based on cytopharmaceuticals is developed. During PTT, the photothermal tumor ablation is accompanied by an inflammatory effect and upregulation of inflammatory factors at the tumor site, which may accelerate tumor regeneration. Moreover, PTT-induced inflammation can also recruit neutrophils (NEs) to the tumor site. Read More

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December 2018

Food Effect Study Design With Oral Drugs: Lessons Learned From Recently Approved Drugs in Oncology.

J Clin Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Quantitative Clinical Pharmacology, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Waltham, MA, USA.

Evaluation of the effect of food on the pharmacokinetics of oral oncology drugs is critical to drug development, as food can mitigate or exacerbate toxicities and alter systemic exposure. Our aim is to expand on current US Food and Drug Administration (FDA) guidance and provide data-driven food-effect study design recommendations specific to the oncology therapeutic area. Data for recently approved small-molecule oncology drugs was extracted from the clinical pharmacology review in the sponsor's FDA submission package. Read More

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December 2018
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The Fyn kinase inhibitor, AZD0530, suppresses mouse alcohol self-administration and seeking.

Addict Biol 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurology, University of California San Francisco, San Francisco, California.

Fyn is a member of the Src family of protein tyrosine kinases (PTKs) that plays an important role not only in normal synaptic functions but also in brain pathologies including alcohol use disorder. We previously reported that repeated cycles of binge drinking and withdrawal activate Fyn in the dorsomedial striatum (DMS) of rodents, and that Fyn signaling in the DMS contributes to rat alcohol intake and relapse. Here, we used AZD0530, a CNS penetrable inhibitor of Src PTKs developed for the treatment of Alzheimer disease and cancer and tested its efficacy to suppress alcohol-dependent molecular and behavioral effects. Read More

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December 2018

Clinical Guidelines in Pediatric Hearing Loss: Systemic Review Using the Appraisal of Guidelines for Research and Evaluation II Instrument.

Laryngoscope 2018 Dec 8. Epub 2018 Dec 8.

Division of Otolaryngology, Department of Surgery, Akron Childrens Hospital Akron, Ohio, U.S.A.

Objectives: Despite the importance, impact, and prevalence of pediatric hearing loss (HL), there are very few published clinical practice guidelines (CPG) supporting the evaluation and management of pediatric patients with HL. Our objective was to appraise existing CPGs to ensure safe and effective practices.

Methods: A literature search was conducted in PubMed, Google Scholar, EBSCO, as well as a manual Google search. Read More

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December 2018

Local injection of RANKL facilitates tooth movement and alveolar bone remodeling.

Oral Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, Seoul, Korea.

Objectives: To investigate the effect of local injection of receptor activator of nuclear factor kappa B ligand (RANKL) on experimental tooth movement and subsequent alveolar bone remodeling in mice.

Materials And Methods: Sixty mice were randomised to receive daily local RANKL or phosphate-buffered saline injections in the buccal premaxillary bone for 14 of 21 days of incisor movement, followed by a 21-day retention period. Five mice from each group were euthanised on days 0, 3, 7, 14, 21, and 42, and specimens were prepared for haematoxylin and eosin, tartrate-resistant acid phosphatase, and immunohistochemical staining. Read More

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December 2018

Clinical utility of plasma miR-371a-3p in germ cell tumors.

J Cell Mol Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Pathology, Laboratory for Experimental Patho-Oncology, Erasmus MC University Medical Center, Cancer Institute, Rotterdam, The Netherlands.

Germ cell tumours predominantly of the testis ((T)GCTs) are remarkably chemotherapy sensitive. However, a small proportion of patients fail to be cured with cisplatin-based combination chemotherapy. miR-371a-3p is a new liquid biopsy biomarker for (T)GCTs. Read More

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December 2018

Differential Mucosal Gene Expression Patterns in Candida-Associated, Chronic Oral Denture Stomatitis.

J Prosthodont 2018 Dec 10. Epub 2018 Dec 10.

Department of Pharmaceutical and Biomedical Sciences, Touro College of Pharmacy, New York, NY.

Purpose: Denture stomatitis is a common condition manifested by inflammation of the oral mucous membrane beneath a denture. The objective of this study was to compare the transcriptome of human palatal mucosa with chronic oral stomatitis-associated Candida albicans infection to that of healthy oral mucosa.

Materials And Methods: Oral palatal biopsies were obtained from 17 healthy and 15 C. Read More

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December 2018

Attenuation of aquaporin-3 and epidermal growth factor receptor expression and activation in systemic sclerosis dermal fibroblasts.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Impaired wound healing and skin dehydration are the mainstay of systemic sclerosis (SSc) cutaneous manifestations. Aquaporin-3 (AQP3) has a pivotal role in skin hydration and wound healing. Epidermal growth factor receptor (EGFR) activation is impaired in SSc fibroblasts. Read More

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December 2018
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Prospective exosome-focused translational research for afatinib study of non-small cell lung cancer patients expressing EGFR (EXTRA study).

Thorac Cancer 2018 Dec 8. Epub 2018 Dec 8.

Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

Patients with EGFR-mutated non-small cell lung cancer (NSCLC) exhibit resistance to EGFR-tyrosine kinase inhibitors (TKIs) within 9-14 months of therapy. Recently, EGFR-mutated NSCLC has demonstrated the potential for heterogeneity; therefore, the manner of clonal heterogeneity may impact the duration of progression-free and overall survival and other parameters affecting EGFR-TKI treatment efficacy. However no predictive biomarker of these favorable treatment efficacies has been identified to date. Read More

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December 2018

Systemic mastocytosis in adults: 2019 update on diagnosis, risk stratification and management.

Am J Hematol 2018 Dec 8. Epub 2018 Dec 8.

Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Overview: Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in extra-cutaneous organs.

Diagnosis: The major criterion is presence of multifocal clusters of abnormal MC in the bone marrow. Minor diagnostic criteria include elevated serum tryptase level, abnormal MC CD25 expression, and presence of KITD816V mutation. Read More

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December 2018
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Oral health-related quality of life in patients with disorders of nutrition.

J Oral Rehabil 2018 Dec 11. Epub 2018 Dec 11.

Department of Community Dentistry, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.

Background: Researchers demonstrated a correlation between nutrition and health-related quality-of-life (HRQoL). Little is known about the correlation between disorders of nutrition (DON) and Oral HRQoL (OHRQoL).

Objectives: 1) to measure OHRQoL in DON patients compared to patients attending nutritional counseling for other reasons (e. Read More

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December 2018

Pharmacokinetics, Safety, and Tolerability Evaluation of Single and Multiple Doses of GSK3342830 in Healthy Volunteers.

Clin Pharmacol Drug Dev 2018 Dec 10. Epub 2018 Dec 10.

GlaxoSmithKline, Clinical Pharmacology Modeling & Simulation, Collegeville, PA, USA.

This was a first-time-in-human randomized, double-blind, single-center, placebo-controlled dose-escalation study to determine the safety, tolerability, and pharmacokinetic (PK) profiles of GSK3342830 after single and repeat intravenous doses in healthy adult subjects (NCT0271424). Sixty-two subjects were enrolled: 48 subjects in part 1 (single dose) and 14 subjects in part 2 (multiple doses). Following single intravenous infusions, total systemic exposure of GSK3342830 was dose proportional over the 250- to 6000-mg dose range evaluated, whereas peak exposure was approximately dose proportional over the dose range. Read More

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December 2018

Galectin-3 exacerbates ox-LDL-mediated endothelial injury by inducing inflammation via integrin β1-RhoA-JNK signaling activation.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Geriatric Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Oxidized low-density lipoprotein (Ox-LDL)-induced endothelial cell injury plays a crucial role in the pathogenesis of atherosclerosis (AS). Plasma galectin-3 (Gal-3) is elevated inside and drives diverse systemic inflammatory disorders, including cardiovascular diseases. However, the exact role of Gal-3 in ox-LDL-mediated endothelial injury remains unclear. Read More

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December 2018

Isotretinoin and Candida immunotherapy for recalcitrant warts in solid organ transplant recipients.

Dermatol Ther 2018 Dec 10:e12803. Epub 2018 Dec 10.

Department of Dermatology, University of Florida.

Treatment of recalcitrant warts in solid organ transplant recipients (SOTR) can pose a therapeutic challenge for dermatologists. Successful treatment of recalcitrant warts can serve as secondary prevention for skin cancer in those with chronic immunosuppression. Given the heterogeneity of associated comorbid conditions in SOTR, clinical trials are difficult to conduct in this high-risk population, therefore, our clinical practice is mostly driven by observed responses from studies in immunocompetent patients or from case reports of immunocompromised patients. Read More

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December 2018
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Utility of adjuvant chemotherapy in patients receiving surgery and adjuvant radiotherapy for primary treatment of esthesioneuroblastoma.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota.

Background: Past research established that surgery plus adjuvant radiotherapy (S + AR) improves overall survival (OS) in esthesioneuroblastoma (ENB). However, it is unknown if the addition of adjuvant chemotherapy (AC) further improves survival. The primary objective of this study was to compare survival among patients treated with S + AR alone to patients who underwent S + AR + AC. Read More

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December 2018

Semi-synthesis, antibacterial activity, and molecular docking study of novel pleuromutilin derivatives bearing cinnamic acids moieties.

Arch Pharm (Weinheim) 2018 Dec 7:e1800266. Epub 2018 Dec 7.

Institute of Veterinary Sciences and Pharmaceuticals, Chongqing Academy of Animal Sciences, Rongchang, China.

To develop new antibiotics owning a special mechanism, we used the molecular assembly method to synthesize a series of novel pleuromutilin derivatives containing a cinnamic acid scaffold at the C-14 side chain. We evaluated their antibacterial activity and used in silico molecular docking to study their binding mode with the target. The structure-activity relationship (SAR) study suggested that compounds with NO (13e), OH (13u), and NH (13y) appeared more active (0. Read More

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December 2018

In vitro modulatory effect of dehydroepiandrosterone sulfate on apoptosis and expression of apoptosis-related genes in patients with systemic lupus erythematosus.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Rheumatology Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives: Systemic lupus erythematosus‌ (SLE) is an autoimmune disease characterized by hyperactive B cells that produce various autoantibodies. Sex hormones have been documented to influence the development of SLE, in which women with SLE have low plasma level of dehydroepiandrosterone sulfate (DHEAS). A strong conclusion about the effect of DHEAS on apoptosis in SLE patients has not been provided. Read More

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December 2018

Effects of normal lymphatic fluid on rats with sepsis complicated with lung injury.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7969-7976

Department of Emergency, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

Objective: Infection can be caused by severe burnt, trauma and hypoxia, further causing systemic inflammatory syndrome or sepsis. The sepsis occurs in about 2% of all hospitalizations and ranges from 6% to 30% in intensive care unit (ICU) in developed countries This study aimed to investigate the effects of normal lymph fluid on sepsis complicated with pulmonary injury.

Materials And Methods: Wistar rats were prepared for sepsis complicated with acute pulmonary model via cecal ligation and puncture, and received normal lymph fluid injection 60 min later. Read More

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November 2018

Polyneuropathy in Severely Obese Women Without Diabetes: Prevalence and Associated Factors.

Obes Surg 2018 Dec 7. Epub 2018 Dec 7.

Programa de Pós-Graduação em Ciências da Saúde: Ginecologia e Obstetrícia, UFRGS, Porto Alegre, Brazil.

Background: Obesity and its complications are prevalent in women and increase with age. Polyneuropathy (PNP) is a complication of obesity and bariatric surgery (BS). In subjects with severe (grades II and III) obesity and without DM who are candidates for BS, the prevalence of PNP and associated conditions are not well characterized. Read More

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December 2018

Inflammasomes in Bone Diseases.

Exp Suppl 2018 ;108:269-279

Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Unresolved inflammation is harmful to any tissues in the organism. Bone in particular is vulnerable to inflammatory assaults because its integrity depends on the activity of osteoclasts, which arise from myeloid precursors. Osteoclasts are responsible for bone resorption in normal and disease conditions. Read More

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January 2018

Inflammasome and Oral Diseases.

Exp Suppl 2018 ;108:153-176

Departament Periodontology, Facultad de Odontología, Universidad de Sevilla, Sevilla, Spain.

One of the main steps in the development of the life in the earth is multicellularity. It enables cell differentiation and the development of morphological structures within an organism and is an essential factor in how to recognize friendly cells that are part of the multicellular organism and which foreign organisms can be harmful. Recognition includes devices such as the major histocompatibility complex (MHC), and the pattern recognition receptors (PRRs). Read More

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January 2018

Efficacy and safety of lanreotide in Korean patients with metastatic, well-differentiated gastroenteropancreatic-neuroendocrine tumors: a retrospective analysis.

Invest New Drugs 2018 Dec 10. Epub 2018 Dec 10.

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

Lanreotide autogel is a long-acting somatostatin analogue with proven efficacy and safety in patients with well-differentiated (WD) gastroenteropancreatic-neuroendocrine tumors (GEP-NETs) in a prior randomized phase III trial (CLARINET). However, the CLARINET study only enrolled patients with Ki-67 index <10%, and few patients of Asian ethnicity were included. We retrospectively analyzed the efficacy and safety of lanreotide in Korean patients with GEP-NETs in the daily practice setting. Read More

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December 2018
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Real-World Use of Talimogene Laherparepvec in German Patients with Stage IIIB to IVM1a Melanoma: A Retrospective Chart Review and Physician Survey.

Adv Ther 2018 Dec 7. Epub 2018 Dec 7.

Amgen Ltd, Uxbridge, UK.

Introduction: Talimogene laherparepvec is a first-in-class oncolytic immunotherapy for intratumoral injection with proven efficacy and tolerability in patients with unresectable early metastatic melanoma (stage IIIB-IVM1a) in the pivotal phase III OPTiM study. The objective was to characterize melanoma patients treated with talimogene laherparepvec in routine clinical practice in Germany.

Methods: A retrospective chart review was conducted in unresectable stage IIIB-IVM1a melanoma patients. Read More

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December 2018

Contrast-free, echocardiography-guided left atrial appendage occlusion (LAAo): a propensity-matched comparison with conventional LAAo using the AMPLATZER™ Amulet™ device.

Clin Res Cardiol 2018 Dec 10. Epub 2018 Dec 10.

Med. Klinik und Poliklinik II-Herzzentrum Bonn, Universitätsklinikum Bonn, Bonn, Germany.

Aims: Percutaneous left atrial appendage occlusion (LAAo) is commonly performed under fluoroscopy including the use of contrast dye. In this study, we aimed to assess feasibility and safety of contrast-free, 3D-echo-based LAAo with the use of the AMPLATZER™ Amulet™ device.

Methods And Results: We analyzed 20 patients (74 ± 10 years, 65% males) at an increased thromboembolic and bleeding risk (CHADSVASC 4. Read More

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December 2018

Pulmonary hypertension in Spanish patients with systemic sclerosis. Data from the RESCLE registry.

Clin Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Autoimmune Diseases Unit, Department of Internal Medicine, Hospital Universitario Vall d'Hebron, Barcelona, Spain.

Introduction: Our objective was to evaluate the pulmonary hypertension (PH) data for Spanish patients with systemic sclerosis (SSc), define the PH types and determine the associated factors.

Method: Descriptive study of PH-related data from the multicentre RESCLE registry. Estimated systolic pulmonary artery pressure (esPAP), measured via echocardiogram was considered elevated if ≥ 35 mmHg. Read More

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December 2018

Treprostinil reduces endothelial damage in murine sinusoidal obstruction syndrome.

J Mol Med (Berl) 2018 Dec 7. Epub 2018 Dec 7.

Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Centre of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

Sinusoidal obstruction syndrome (SOS) is a major complication after hematopoietic stem cell transplantation and belongs to a group of diseases increasingly identified as transplant-related systemic endothelial disease. Administration of defibrotide affords some protection against SOS, but the effect is modest. Hence, there is unmet medical need justifying the preclinical search for alternative approaches. Read More

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December 2018

An unusual case of pulmonary fat embolism following blunt trauma.

Forensic Sci Med Pathol 2018 Dec 7. Epub 2018 Dec 7.

Institute of Forensic Medicine, University of Belgrade - School of Medicine, 31a Deligradska str, Belgrade, 11000, Serbia.

Fat embolism is markedly underdiagnosed, even though it is a well-known phenomenon following fractures of the long bones, injury to subcutaneous fat tissue, rupture of a fatty liver, surgical operations on fatty tissues, septicemia, burns and barotrauma. Forensic pathologists tend to "simplify" autopsy report conclusion in cases with multiple injuries where fat embolism and exsanguination could be considered to be the concomitant causes of death. Herein we present a case of 24-year-old male who was beaten with a metal rod by several persons. Read More

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December 2018
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[Clinical picture and diagnosis of neurotrophic keratopathy].

Authors:
E M Messmer

Ophthalmologe 2018 Dec 7. Epub 2018 Dec 7.

Augenklinik, Ludwig-Maximilians-Universität München, Mathildenstr. 8, 80336, München, Deutschland.

Background: Neurotrophic keratopathy is characterized by corneal surface alterations, persistent corneal epithelial defects and/or corneal ulcerations associated with corneal sensory abnormalities. Due to the variable clinical picture neurotrophic keratopathy is often overlooked or diagnosed too late in the course of the disease.

Objective: Discussion of the clinical picture of neurotrophic keratopathy and recommendations for correct diagnosis. Read More

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December 2018

(R)-GEMOX chemotherapy for unfit patients with refractory or recurrent primary central nervous system lymphoma: a LOC study.

Ann Hematol 2018 Dec 7. Epub 2018 Dec 7.

APHM, service de Neuro-Oncologie, Timone Hospital, CHU Timone, 264 rue saint Pierre, 13005, Marseille, France.

Recurrent primary central nervous system lymphomas (PCNSL) have a very poor prognosis. For young and fit patients, intensive chemotherapy followed by autologous stem cell transplantation could be proposed at relapse. In the other cases (unfit or elderly patients), therapeutic options are limited with no consensual regimen. Read More

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December 2018

Disease-specific characteristics of vascular cell adhesion molecule-1 levels in patients with peripheral artery disease.

Heart Vessels 2018 Dec 7. Epub 2018 Dec 7.

Department of Internal Medicine I, Friedrich Schiller University Jena, Jena, Germany.

Peripheral arterial disease (PAD) is one of the most common manifestations of systemic atherosclerosis. The prevalence of unrecognized PAD is high, leading to a lack of opportunity to detect subjects at a high risk for cardiovascular events. Inflammatory processes play an important role in the disease initiation as well as in the disease progression. Read More

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December 2018
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Macrophage activation syndrome in a patient with axial spondyloarthritis on adalimumab.

Clin Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Division of Rheumatology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.

Macrophage activation syndrome (MAS) is a rare and potentially fatal condition characterized by excessive activation and uncontrolled proliferation of T lymphocytes and macrophages, leading to overwhelming systemic inflammation and cytokine release. MAS has been reported with viral infections, autoimmune disorders, malignancies, and medications. We describe a case of a patient with axial spondyloarthritis (axSpA) treated with adalimumab, who presented with MAS. Read More

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December 2018