72,846 results match your criteria Systemic Lupus Erythematosus


Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA.

Immunity 2020 May 19. Epub 2020 May 19.

Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA; Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA. Electronic address:

Class-switched antibodies to double-stranded DNA (dsDNA) are prevalent and pathogenic in systemic lupus erythematosus (SLE), yet mechanisms of their development remain poorly understood. Humans and mice lacking secreted DNase DNASE1L3 develop rapid anti-dsDNA antibody responses and SLE-like disease. We report that anti-DNA responses in Dnase1l3 mice require CD40L-mediated T cell help, but proceed independently of germinal center formation via short-lived antibody-forming cells (AFCs) localized to extrafollicular regions. Read More

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http://dx.doi.org/10.1016/j.immuni.2020.04.015DOI Listing

Sweet Syndrome in a Patient With Systemic Lupus Erythematosus.

J Clin Rheumatol 2020 Jun;26(4):e85-e86

From the Division of Internal Medicine, Spectrum Health-Michigan State University, College of Human Medicine, Grand Rapids, MI.

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http://dx.doi.org/10.1097/RHU.0000000000000904DOI Listing

Osteonecrosis and Multifocal Bone Infarction in Systemic Lupus Erythematosus.

Authors:
Joe Thomas

J Clin Rheumatol 2020 Jun;26(4):e77

From the Department of Orthopaedics & Rheumatology, Aster Medcity, Kochi, Kerala, India.

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http://dx.doi.org/10.1097/RHU.0000000000000859DOI Listing

Hsp70 Gene Polymorphisms Are Associated With Disease Susceptibility and HRQOL Improvement in Chinese Han Population With Systemic Lupus Erythematosus.

J Clin Rheumatol 2020 Jun;26(4):134-141

From the Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University.

Objectives: The aim of this study is to investigate whether heat shock protein 70 (Hsp70) gene polymorphisms are implicated in systemic lupus erythematous (SLE) susceptibility, the efficacy of glucocorticoids (GCs) treatment, and improvement of health-related quality of life.

Methods: A total of 499 SLE patients and 499 controls were included in a case-control study, and 468 SLE patients treated with GCs for 12 weeks were involved in a follow-up study. Patients who completed the 12-week follow-up were divided into GCs-sensitive and GCs-insensitive group by using the SLE disease activity index. Read More

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http://dx.doi.org/10.1097/RHU.0000000000000986DOI Listing

Comparison of safety, efficacy and cost between oral pulse cyclophosphamide versus intravenous cyclophosphamide pulse therapy in severe systemic lupus erythematosus.

Int J Rheum Dis 2020 May 25. Epub 2020 May 25.

Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India.

Objectives: The aim of this study is to compare efficacy, toxicity and cost between oral and intravenous cyclophosphamide (CYC) pulse therapy in inducing remission (Systemic Lupus Erythematosus Disease Activity Index [SLEDAI] <3) in severe SLE.

Methods: We retrospectively checked the hospital records of patients between the years 2000 and 2018, who had been administered oral cyclophosphamide pulse and intravenous (IV) cyclophosphamide pulse. SLEDAI at baseline and after 6 months of therapy were noted. Read More

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http://dx.doi.org/10.1111/1756-185X.13823DOI Listing

Single-nucleotide polymorphisms influence the promoter activities of systemic lupus erythematosus-associated genes.

Biotechnol Lett 2020 May 25. Epub 2020 May 25.

Department of Laboratory Medicine, Pingshan District People's Hospital, Shenzhen, 518118, Guangdong, China.

Systemic lupus erythematosus (SLE) is a protypical autoimmune disease and genetic factors play important roles in its pathogenesis. Since present SLE susceptibility loci are mainly studied through meta-analysis of genome-wide association study, we performed promoter activity analysis to examine the biological functions of SLE-associated single-nucleotide polymorphisms (SNPs). We found at SNP positions rs1341239, rs1800795, rs1800796, rs1800872, rs1800871, rs187238, rs360719, rs8178822, rs3761549, different alleles influenced respective promoter activities in different manners, and the effects also appeared under glucocorticoid treatment. Read More

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http://dx.doi.org/10.1007/s10529-020-02916-yDOI Listing

Response to: 'Are patients with systemic lupus erythematosus at increased risk for COVID-19?' by Favalli .

Ann Rheum Dis 2020 May 25. Epub 2020 May 25.

Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière, French National Referral Center for Systemic Lupus Erythematosus, Antiphospholipid Antibody Syndrome and Other Autoimmune Disorders, Service de Médecine Interne 2, Institut E3M, Inserm UMRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.

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http://dx.doi.org/10.1136/annrheumdis-2020-217859DOI Listing

Are patients with systemic lupus erythematosus at increased risk for COVID-19?

Ann Rheum Dis 2020 May 25. Epub 2020 May 25.

Division of Clinical Rheumatology, Gaetano Pini-CTO, Milano, Lombardia, Italy.

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http://dx.doi.org/10.1136/annrheumdis-2020-217787DOI Listing

Autoantibodies to neutrophil extracellular traps represent a potential serological biomarker in rheumatoid arthritis.

J Autoimmun 2020 May 22:102484. Epub 2020 May 22.

Department of Biomolecular Chemistry, Institute of Molecules and Materials (IMM), Radboud University, Nijmegen, the Netherlands. Electronic address:

Neutrophil extracellular traps (NETs) are networks of extracellular chromatin decorated with antimicrobial proteins, formed by neutrophils to entrap pathogens. NETs have been implicated in the generation of autoimmune reactions. Here, we investigate the reactivity of rheumatoid arthritis (RA) serum antibodies with NETs and explore whether anti-NET antibodies (ANETA) have a potential as biomarker in RA. Read More

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http://dx.doi.org/10.1016/j.jaut.2020.102484DOI Listing

Serum adiponectin levels are associated with presence of carotid plaque in women with systemic lupus erythematosus.

Nutr Metab Cardiovasc Dis 2020 Mar 27. Epub 2020 Mar 27.

IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network, 10 Largo Benzi, 16132 Genoa, Italy.

Background And Aim: Systemic lupus erythematosus (SLE) is associated with accelerated atherogenesis. Traditional risk factors do not seem to fully explain this process in patients with SLE and no other imaging/serum biomarkers have so far improved risk stratification. Here, we focused on the role of adiponectin in women with SLE. Read More

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http://dx.doi.org/10.1016/j.numecd.2020.03.020DOI Listing

Long-term outcome of a randomised controlled trial comparing tacrolimus with mycophenolate mofetil as induction therapy for active lupus nephritis.

Ann Rheum Dis 2020 May 24. Epub 2020 May 24.

Medicine, United Christian Hospital, Hong Kong, Hong Kong.

Objectives: To report the 10-year outcome of lupus nephritis (LN) treated with mycophenolate mofetil (MMF) or tacrolimus (TAC) induction in a randomised controlled trial.

Methods: Patients with active LN were treated with MMF or TAC combined with high-dose prednisolone. Responders were switched to azathioprine (AZA) at month 6. Read More

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http://dx.doi.org/10.1136/annrheumdis-2020-217178DOI Listing

Perceptions of women with systemic lupus erythematosus undergoing high-risk prenatal care: A qualitative study.

Midwifery 2020 May 13;87:102715. Epub 2020 May 13.

Department of Gynecology and Obstetrics, School of Medical Science University of Campinas (UNICAMP), Brazil. R. Alexander Fleming 101, ZIP: 13083-881, Campinas, SP, Brazil. Electronic address:

Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that often leads to situations of harm to the mother-fetus binomial. Given the potential for complications and morbidities in these pregnant women, it is essential that a multidisciplinary team be involved in pregnancy planning, as well as monitoring the course of the pregnancy and the postpartum period. Owing to the imminent risks of disease worsening along with consequent disabilities, these women may experience psychological and psychosocial impacts conflicting with the psychological demands of pregnancy. Read More

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http://dx.doi.org/10.1016/j.midw.2020.102715DOI Listing

Autoantibody-positive healthy individuals with lower lupus risk display a unique immune endotype.

J Allergy Clin Immunol 2020 May 21. Epub 2020 May 21.

Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK; Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. Electronic address:

Background: Autoimmune diseases comprise a spectrum of illnesses and are on the rise worldwide. Although anti-nuclear antibodies (ANA) are detected in many autoimmune diseases, up to 20% of healthy women are ANA+ and most will never develop clinical symptoms. Further, disease transition is higher among ANA+ African Americans compared to European Americans. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.04.047DOI Listing

A population-based study of risk factors for heart failure in pediatric and adult-onset systemic lupus erythematosus.

Semin Arthritis Rheum 2020 May 3;50(4):527-533. Epub 2020 May 3.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Objectives: The increased relative risk of heart failure (HF) from systemic lupus erythematosus (SLE) is greatest at younger ages, but the etiology remains unclear. We identified risk factors for HF in children and adults with SLE and evaluated associations between SLE manifestations and HF.

Methods: Incident SLE cases without preceding HF were identified using Clinformatics DataMart® (OptumInsight, Eden Prairie, MN) US claims data (2000-2015), and categorized by age of SLE onset (children 5-17, young adults 18-24, adults 25-44 years old). Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.03.019DOI Listing

Biocompatible nanovesicular drug delivery systems with targeting potential for autoimmune diseases.

Curr Pharm Des 2020 May 23. Epub 2020 May 23.

Delhi Pharmaceutical Sciences and Research University, New Delhi. India.

Autoimmune diseases are collectively addressed as chronic conditions initiated by loss of one's immunological tolerance, where body treats its own cells as foreigners or self-antigens. These hay-wired antibodies or immunologically capable cells lead to variety of disorders like rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, multiple sclerosis and recently included neurodegenerative diseases like Alzheimer's, Parkinsonism and testicular cancer triggered T-cells induced autoimmune response in testes and brain. Conventional treatments for autoimmune diseases possess several downsides due to unfavourable pharmacokinetic behaviour of drug, reflected by low bioavailability, rapid clearance, offsite toxicity, restricted targeting ability and poor therapeutic outcomes. Read More

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http://dx.doi.org/10.2174/1381612826666200523174108DOI Listing

Good response to cryofiltration in a patient with cryoglobulinemic vasculitis complicated with systemic lupus erythematosus.

Ther Apher Dial 2020 May 23. Epub 2020 May 23.

Department of Immuno-Rheumatology Center, Arisawa General Hospital, 12-14 Higashino-cho, Nakamiya, Hirakata, Osaka, Japan.

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http://dx.doi.org/10.1111/1744-9987.13529DOI Listing

The Epigenetics of Lupus Erythematosus.

Adv Exp Med Biol 2020 ;1253:185-207

Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disease that is characterized by dysregulated dendritic cells, T and B cells, and abundant autoantibodies. The pathogenesis of lupus remains unclear. However, increasing evidence has shown that environment factors, genetic susceptibilities, and epigenetic regulation contribute to abnormalities in the immune system. Read More

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http://dx.doi.org/10.1007/978-981-15-3449-2_7DOI Listing
January 2020

Epigenetic Methods and Twin Studies.

Adv Exp Med Biol 2020 ;1253:95-104

Humanitas Clinical and Research Center-IRCCS, via Manzoni 56, 20089, Rozzano, Milan, Italy.

Genomic predisposition fails to fully explain the onset of complex diseases, which is well illustrated by the largely incomplete concordance among monozygotic twins. Epigenetic mechanisms, including DNA methylation, chromatin remodeling, and non-coding RNA, are the link between environmental stimuli and disease onset on a permissive genetic background in autoimmune and chronic inflammatory diseases. Autoimmune diseases now include almost 100 conditions and are estimated to cumulatively affect up to 5% of the world population with a healthcare expenditure superior to cancer worldwide. Read More

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http://dx.doi.org/10.1007/978-981-15-3449-2_3DOI Listing
January 2020

Acute myocardial dysfunction in lupus: outcomes in Asian Indians.

Clin Rheumatol 2020 May 22. Epub 2020 May 22.

Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Background: Acute myocardial dysfunction is an uncommon but potentially fatal complication in systemic lupus erythematosus (SLE). We describe the outcome in a small series of Asian Indian patients and examine associated factors.

Methods: SLE patients who fulfilled the 2012 SLICC criteria and developed new-onset myocardial dysfunction were included in this retrospective case series. Read More

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http://dx.doi.org/10.1007/s10067-020-05177-2DOI Listing

Management of Lupus Nephritis in Children.

Indian Pediatr 2020 May;57(5):401-406

Clinical Pediatrics, Perelman School of Medicine University of Pennsylvania, Children's Hospital of Philadelphia, PA, United States of America. Correspondence to: Dr Madhura Pradhan, Children's Hospital of Philadelphia, PA 19104, USA.

Lupus nephritis affects 50-75% of all children with systemic lupus erythematosus with a higher prevalence in Asians. It remains a major contributor to morbidity and mortality in childhood onset lupus. Proliferative lupus nephritis (class III and class IV) warrants aggressive treatment to prevent progression to end stage renal disease. Read More

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Association between organ damage and mortality in systemic lupus erythematosus: a systematic review and meta-analysis.

BMJ Open 2020 May 21;10(5):e031850. Epub 2020 May 21.

BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Maryland, USA

Objective: At least half of patients with systemic lupus erythematosus (SLE) develop organ damage as a consequence of autoimmune disease or long-term therapeutic steroid use. This study synthesised evidence on the association between organ damage and mortality in patients with SLE.

Design: Systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-031850DOI Listing

Neutrophil and lymphocyte counts are associated with different immunopathological mechanisms in systemic lupus erythematosus.

Lupus Sci Med 2020 May;7(1)

Department of Medicine, Division of Rheumatology, University of Washington, Seattle, Washington, USA

Objective: Neutrophils contribute to the SLE pathogenesis. Neutrophil to lymphocyte ratio (NLR) is reported to correlate with disease activity in SLE. The aim of the study was to evaluate whether NLR reflects underlying immunopathogenic activity in SLE, as well as to determine the contribution of each component of NLR, neutrophil and lymphocyte count. Read More

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http://dx.doi.org/10.1136/lupus-2020-000382DOI Listing

Modulation of iron homeostasis with hepcidin ameliorates spontaneous murine lupus nephritis.

Kidney Int 2020 Feb 17. Epub 2020 Feb 17.

Division of Nephrology, Center for Immunity, Inflammation and Regeneration, University of Virginia, Charlottesville, Virginia, USA. Electronic address:

Lupus nephritis is the end organ manifestation of systemic lupus erythematosus. Iron metabolism and its master regulator, hepcidin, are known to regulate cell proliferation and inflammation, but their direct role in the pathophysiology of lupus nephritis remains under-investigated. Exogenous hepcidin reduced the severity of lupus nephritis in MRL/lpr mice, a preclinical model of spontaneous systemic lupus erythematosus without worsening anemia of inflammation. Read More

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http://dx.doi.org/10.1016/j.kint.2020.01.025DOI Listing
February 2020

Genetic heterogeneity of pediatric systemic lupus erythematosus with lymphoproliferation.

Medicine (Baltimore) 2020 May;99(20):e20232

Department of Rheumatology.

Systemic lupus erythematosus (SLE) is a chronic, rare autoimmune disease. In recent years, multiple monogenic diseases with early onset autoimmunity and lymphoproliferation have been identified, such as autoimmune lymphoproliferative syndrome, rat sarcoma (RAS)-associated autoimmune leukoproliferative disease, signal transducer and activator of transcription 3 gain-of-function syndrome and interleukin-2 receptor α deficiency. Therefore, we performed whole-exome sequencing in children with SLE with lymphoproliferation to identify genes associated with these conditions. Read More

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http://dx.doi.org/10.1097/MD.0000000000020232DOI Listing

Study on the correlation between anti-ribosomal P protein antibody and systemic lupus erythematosus.

Medicine (Baltimore) 2020 May;99(20):e20192

The aims of this study were to compare diagnostic value of anti-ribosomal P protein antibody (anti-P), anti-Smith antibody (anti-Sm), anti-double-stranded DNA antibody (anti-dsDNA), anti-nucleosome antibody (ANuA), and anti-histone antibody (AHA) for systemic lupus erythematosus (SLE) as well as explore the correlation between anti-P and SLE.A retrospective study was performed with 487 SLE patients, 235 non-SLE rheumatic diseases, and 124 healthy subjects from January 2015 to December 2018. Clinical manifestations, laboratory results and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)-2000 scores were analyzed between anti-P/+/ and anti-P/-/ patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000020192DOI Listing

Risk factors for hydroxychloroquine retinopathy in systemic lupus erythematosus: a case-control study with hydroxychloroquine blood-level analysis.

Rheumatology (Oxford) 2020 May 23. Epub 2020 May 23.

Department of Internal Medicine, Centre de Référence Maladies Auto-Immunes et Systémiques Rares d'Ile de France, Cochin Hospital, APHP, Paris, France.

Objective: HCQ is an essential medication in SLE, proven to lengthen survival and reduce flares. Its use, however, is limited by its rare but severe ophthalmological complications. Here, we aimed to analyse factors associated with HCQ retinopathy including HCQ blood levels. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa157DOI Listing

Rituximab-associated hypogammaglobulinaemia in ANCA-associated vasculitis and connective tissue diseases: a longitudinal observational study.

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):188-194. Epub 2020 May 22.

Rheumatology Unit, Department of Medicine DIMED, University of Padova, Italy.

Objectives: The burden of hypogammaglobulinaemia following rituximab (RTX) treatment in rheumatic diseases has not been fully elucidated yet. Our aim was to evaluate the frequency and predictors of hypogammaglobulinaemia in patients affected by ANCA-associated vasculitis (AAV) and connective tissue diseases (CTD).

Methods: We retrospectively reviewed prospectively collected data of patients receiving RTX. Read More

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An atypical presentation of alopecia in discoid lupus erythematosus.

J Cutan Pathol 2020 May 22. Epub 2020 May 22.

Department of Dermatology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.

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http://dx.doi.org/10.1111/cup.13758DOI Listing

Cerebellar ataxia as a first manifestation of systemic lupus erythematosus.

Acta Neurol Belg 2020 May 21. Epub 2020 May 21.

Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.

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http://dx.doi.org/10.1007/s13760-020-01376-5DOI Listing

A National Analysis of Coronary Artery Bypass Grafting in Autoimmune Connective Tissue Disease.

Ann Thorac Surg 2020 May 18. Epub 2020 May 18.

Division of Cardiac Surgery, University of California, Los Angeles, Los Angeles, California. Electronic address:

Background: Autoimmune connective tissue diseases (CTD) are associated with accelerated atherosclerosis and inflammation, while often requiring immunosuppression. Large scale outcomes of coronary artery bypass graft (CABG) surgery in this population have not been reported thus far. This study characterized trends in utilization of CABG in patients with CTD and the impact of the disease on mortality, in-hospital complications, length of stay (LOS) and costs. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.03.120DOI Listing

Adherence to hydroxychloroquine in patients with systemic lupus: contrasting results and weak correlation between assessment tools.

Joint Bone Spine 2020 May 10. Epub 2020 May 10.

Département de Médecine Interne et Immunologie Clinique, CHU Lille, Referral center for rare systemic autoimmune diseases North and Northwest of France, Univ. Lille, INSERM U995 - LIRIC - Lille Inflammation Research International Center, 59000 Lille, France.

Objectives: Hydroxychloroquine (HCQ) is an anchor drug in the treatment of systemic lupus erythematosus (SLE). Adherence to HCQ is key for efficacy. Inaccurate evaluation of adherence could lead to non-justified switch to more expensive or less tolerated drugs. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.04.017DOI Listing

Long-term outcomes of lupus nephritis treated with regimens based on cyclophosphamide and mycophenolate mofetil.

Lupus 2020 May 21:961203320926256. Epub 2020 May 21.

Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Introduction: Lupus nephritis (LN) has a considerable impact on the morbidity and mortality of systemic lupus erythematosus (SLE) patients. Long-term comparative outcome data from the Indian subcontinent on treatment regimens with cyclophosphamide (CYP) and mycophenolate mofetil (MMF) are sparse. We assessed renal and patient survival for these patients in terms of the types of induction - CYP or MMF - and the two maintenance therapies - MMF or azathioprine (AZA). Read More

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http://dx.doi.org/10.1177/0961203320926256DOI Listing
May 2020
2.197 Impact Factor

Comprehensive bioinformatics analysis of mRNA expression profiles and identification of a miRNA-mRNA network associated with lupus nephritis.

Lupus 2020 May 21:961203320925155. Epub 2020 May 21.

Department of pharmacy, Shanxi Provincial People's Hospital of Shanxi Medical University, Taiyuan, PR China.

Objective: Lupus nephritis (LN) is one of the serious complications of systemic lupus erythematosus. The aim of this study was to identify core genes and pathways involved in the pathogenesis of LN.

Methods: We screened differentially expressed genes (DEGs) in LN patients using mRNA expression profile data from the Gene Expression Omnibus. Read More

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http://dx.doi.org/10.1177/0961203320925155DOI Listing

Clusters in Pediatric Rheumatic Diseases.

Curr Rheumatol Rep 2020 May 20;22(7):28. Epub 2020 May 20.

Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100, Ankara, Turkey.

Purpose Of The Review: Rheumatic diseases usually have very diverse and complex pathophysiology resulting in different clinical phenotypes. Some certain phenotypes cluster together with a common presentation, course, and outcome. Our primary aim is to review the known disease clusters in certain rheumatological conditions. Read More

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http://dx.doi.org/10.1007/s11926-020-00908-5DOI Listing

Analysis of clinical and laboratory characteristics and pathology of lupus nephritis-based on 710 renal biopsies in China.

Clin Rheumatol 2020 May 20. Epub 2020 May 20.

Department of Nephrology, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Medical School of Chinese PLA, the First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China.

Objectives: This study aimed to analyse the clinical and laboratory characteristics of different pathologic classifications of lupus nephritis (LN) patients in terms of age at systemic lupus erythematosus (SLE) diagnosis and nephritis onset.

Method: Clinical, laboratory, and pathological data of 710 LN patients diagnosed by renal biopsy at our institution between 2000 and 2018 were retrospectively analysed. Patients were divided into the different pathological classification groups; childhood-, adult- and elderly-onset SLE groups and early- and late-onset LN groups. Read More

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http://dx.doi.org/10.1007/s10067-020-05115-2DOI Listing

Anti-Inflammatory Properties of Chemical Probes in Human Whole Blood: Focus on Prostaglandin E Production.

Front Pharmacol 2020 6;11:613. Epub 2020 May 6.

Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.

We screened 57 chemical probes, high-quality tool compounds, and relevant clinically used drugs to investigate their effect on pro-inflammatory prostaglandin E (PGE) production and interleukin-8 (IL-8) secretion in human whole blood. Freshly drawn blood from healthy volunteers and patients with systemic lupus erythematosus (SLE) or dermatomyositis was incubated with compounds at 0.1 or 1 µM and treated with lipopolysaccharide (LPS, 10 µg/ml) to induce a pro-inflammatory condition. Read More

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http://dx.doi.org/10.3389/fphar.2020.00613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218097PMC

Total Serum Calcium Level Is Negatively Correlated With Systemic Lupus Erythematosus Activity.

Dose Response 2020 Apr-Jun;18(2):1559325820926764. Epub 2020 May 13.

Department of Immunology, Nanjing Medical University, Nanjing, China.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease and hypocomplementemia signifies disease activity. Several studies have shown that calcium may help maintain optimum function of immune system and metabolism in SLE. The aim of our study was to analyze the relationship between total serum calcium level and SLE activity. Read More

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http://dx.doi.org/10.1177/1559325820926764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223868PMC

Systemic lupus erythematosus presenting with status epilepticus and acute cardiomyopathy with acute heart failure: case report.

Egypt J Neurol Psychiatr Neurosurg 2020 29;56(1):15. Epub 2020 Jan 29.

National Hospital of Sri Lanka, Colombo, Sri Lanka.

Introduction: Systemic lupus erythematosus is a connective tissue disorder, which causes complex multi organ involvement. Neurological and cardiac manifestations have been well noted but complications such as status epilepticus and acute myocarditis with heart failure at presentation remains uncommon.

Case Description: A 15-year-old, previously healthy, South Asian, Sri Lankan female presented with status epilepticus and the seizures only responded to intravenous midazolam and thiopentone sodium. Read More

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http://dx.doi.org/10.1186/s41983-020-0149-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223658PMC
January 2020

Clinical impact of hydroxychloroquine dose adjustment according to the American Academy of Ophthalmology guidelines in systemic lupus erythematosus.

Lupus Sci Med 2020 May;7(1)

Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico

Objective: The American Academy of Ophthalmology recommends a maximum hydroxychloroquine (HCQ) dose of ≤5.0 mg/kg/day to reduce the risk of HCQ-induced retinopathy. To determine if this dose adjustment would have an impact on the clinical course of SLE, we compared outcome measures in a cohort of patients with SLE before and after adjusting HCQ dose. Read More

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http://dx.doi.org/10.1136/lupus-2020-000395DOI Listing

Physician's global assessment is often useful in SLE, but not always: the case of clinical remission.

Ann Rheum Dis 2020 May 20. Epub 2020 May 20.

Department of Medicine DIMED, Division of Rheumatology, University of Padua, Padova, Italy

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http://dx.doi.org/10.1136/annrheumdis-2020-217611DOI Listing

Hydroxychloroquine is neutral in risk of chronic kidney disease in patients with systemic lupus erythematosus.

Ann Rheum Dis 2020 May 20. Epub 2020 May 20.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

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http://dx.doi.org/10.1136/annrheumdis-2020-217728DOI Listing

Hydroxychloroquine shortages during the COVID-19 pandemic.

Ann Rheum Dis 2020 May 20. Epub 2020 May 20.

Division of Rheumatology, McGill University Health Centre, Montreal, Québec, Canada.

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http://dx.doi.org/10.1136/annrheumdis-2020-217835DOI Listing

Response to: 'Phsician's global assessment is often useful in SLE, but not always: the case of clinical remission' by Zen .

Ann Rheum Dis 2020 May 20. Epub 2020 May 20.

The Feinstein Institute for Medical Research, Manhasset, New York, USA

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http://dx.doi.org/10.1136/annrheumdis-2020-217687DOI Listing
May 2020
10.377 Impact Factor

Response to: 'Hydroxychloroquine is neutral in risk of chronic kidney disease in patients with systemic lupus erythematosus' by Wu .

Ann Rheum Dis 2020 May 20. Epub 2020 May 20.

Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, "Attikon" University Hospital, Athens, Greece.

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http://dx.doi.org/10.1136/annrheumdis-2020-217804DOI Listing

A Comparison of 2019 EULAR/ACR SLE Classification Criteria with Two Sets of Earlier SLE Classification Criteria.

Arthritis Care Res (Hoboken) 2020 May 20. Epub 2020 May 20.

Division of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Objective: The Systemic Lupus International Collaborating Clinics (SLICC) 2012 SLE classification criteria and the revised American College of Rheumatology (ACR) 1997 criteria are list-based, counting each SLE manifestation equally. We derived a classification rule based on giving variable weights to the SLICC criteria, and compared its performance to the revised ACR 1997, unweighted SLICC 2012 and the newly reported European League Against Rheumatism (EULAR)/ACR 2019 criteria.

Methods: The physician-rated patient scenarios used to develop the SLICC 2012 classification criteria were re-employed to devise a new weighted classification rule using multiple linear regression. Read More

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http://dx.doi.org/10.1002/acr.24263DOI Listing

A preeclampsia risk prediction model for Chinese pregnant patients with systemic lupus erythematosus.

Arthritis Care Res (Hoboken) 2020 May 20. Epub 2020 May 20.

Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Objective: To screen for a high risk of preeclampsia (PE) in women with systemic lupus erythematosus (SLE).

Methods: Five hundred thirteen antenatal care records of pregnant SLE patients were obtained and the data were randomly assigned to either a development set (n=342) or a validation set (n=171). PE predictors were identified with stepwise regression, and coefficient B of each variable was used to establish a prediction model and risk scoring system. Read More

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http://dx.doi.org/10.1002/acr.24265DOI Listing

Identifying a response for the systemic lupus erythematosus disease activity glucocorticoid index (SLEDAI-2KG).

Arthritis Care Res (Hoboken) 2020 May 20. Epub 2020 May 20.

University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada.

Objective: To compare the performance of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and SLEDAI-2K glucocorticoids (SLEDAI-2KG) indices in identifying responders to standard of care (SoC) therapy.

Methods: Data from adult patients seen between 1995-2018 at the University of Toronto Lupus Clinic was analyzed. Patients with active disease (SLEDAI-2K ≥6) and on prednisone ≥ 5 mg/day, and with a follow up visit at 9 months were studied. Read More

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http://dx.doi.org/10.1002/acr.24261DOI Listing

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.

Nature 2020 05 13;581(7808):316-322. Epub 2020 May 13.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses. Here we show that a previously uncharacterized protein encoded by CXorf21-a gene that is associated with systemic lupus erythematosus-interacts with the endolysosomal transporter SLC15A4, an essential but poorly understood component of the endolysosomal TLR machinery also linked to autoimmune disease. Loss of this type-I-interferon-inducible protein, which we refer to as 'TLR adaptor interacting with SLC15A4 on the lysosome' (TASL), abrogated responses to endolysosomal TLR agonists in both primary and transformed human immune cells. Read More

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http://dx.doi.org/10.1038/s41586-020-2282-0DOI Listing