130,176 results match your criteria Systemic Inflammatory Response Syndrome


[Comparación de la escala qSOFA para evaluar la falla orgánica secuencial y los criterios SIRS para sepsis a la cabecera de pacientes con bacteriemia por Staphylococcus aureus].

Biomedica 2020 May 1;40(Supl. 1):125-131. Epub 2020 May 1.

Grupo de Investigación en Medicina interna, Universidad Tecnológica de Pereira, Pereira, Colombia.

Introducción. Staphylococcus aureus es una de las principales causas de bacteriemia, adquirida en la comunidad o asociada con la atención en salud, la cual presenta un gran porcentaje de complicaciones y elevadas tasas de morbilidad y mortalidad. Los criterios SRIS (Systemic Inflammatory Response Syndrome) se han usado tradicionalmente con el fin de establecer la presencia de sepsis; sin embargo, recientemente se ha cuestionado su valor predictivo dada su baja sensibilidad y especificidad. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7705/biomedica.4943DOI Listing

Meloxicam ameliorates the systemic inflammatory response syndrome associated with experimentally induced endotoxemia in adult donkeys.

J Vet Intern Med 2020 May 28. Epub 2020 May 28.

Department of Animal Medicine and Surgery, University of Cordoba, Campus Rabanales, Road Madrid-Cadiz km 396, 14104, Cordoba, Spain.

Background: Little information is available about endotoxemia in donkeys. Characterizing the systemic inflammatory response (SIRS) to lipopolysaccharide (LPS) in donkeys would provide valuable clinical and therapeutic information. The effects of meloxicam on endotoxemia have not been studied in this species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jvim.15783DOI Listing

Diagnostic Value of miR-103 in Patients with Sepsis and Noninfectious SIRS and Its Regulatory Role in LPS-Induced Inflammatory Response by Targeting TLR4.

Int J Genomics 2020 13;2020:2198308. Epub 2020 May 13.

Clinical Laboratory, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, China.

Background: Sepsis is a life-threatening condition and a systemic inflammatory response syndrome (SIRS) driven by infection. This study aimed at investigating the expression of microRNA-103 (miR-103) in sepsis patients, evaluating its diagnostic value, and exploring the regulatory effect of miR-103 on LPS-induced inflammation in monocytes.

Methods: Expression of miR-103 was measured using quantitative real-time PCR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/2198308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243004PMC

Warifteine and methylwarifteine inhibited the type 2 immune response on combined allergic rhinitis and asthma syndrome (CARAS) experimental model through NF-кB pathway.

Int Immunopharmacol 2020 May 21;85:106616. Epub 2020 May 21.

Laboratório de Imunofarmacologia, Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, Brazil. Electronic address:

CARAS is an airway inflammation of allergic individuals, with a type 2 immune response. The pharmacotherapy is based on drugs with relevant side effects. Thus, the goal of this study evaluated the alkaloids warifteine (War) and methylwarifteine (Mwar) from Cissampelos sympodialis in CARAS experimental model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2020.106616DOI Listing

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system.

Cytokine Growth Factor Rev 2020 May 11. Epub 2020 May 11.

Istituti Clinici Scientifici Maugeri IRCCS, Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, 27100 Pavia, PV, Italy; Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, PV, Italy. Electronic address:

In 2019-2020 a new coronavirus named SARS-CoV-2 was identified as the causative agent of a several acute respiratory infection named COVID-19, which is causing a worldwide pandemic. There are still many unresolved questions regarding the pathogenesis of this disease and especially the reasons underlying the extremely different clinical course, ranging from asymptomatic forms to severe manifestations, including the Acute Respiratory Distress Syndrome (ARDS). SARS-CoV-2 showed phylogenetic similarities to both SARS-CoV and MERS-CoV viruses, and some of the clinical features are shared between COVID-19 and previously identified beta-coronavirus infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cytogfr.2020.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211650PMC

Hepatic complications of COVID-19 and its treatment.

Authors:
Dandan Tian Qing Ye

J Med Virol 2020 May 21. Epub 2020 May 21.

National Clinical Research Center for Child Health, National Children's Regional Medical Center, the Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China.

COVID-19 is highly contagious and has a variety of clinical manifestations, it can affect a number of other organs in addition to the lungs, and liver injury may occur. SARS-CoV-2 can cause liver injury through systemic inflammatory response syndrome (SIRS), cytokine storms, ischemia-reperfusion injury, side effects of treatment drugs, and underlying liver disease and can attack liver cells directly via ACE2. Clinical studies have found that liver injury in COVID-19 patients mainly manifests as abnormal liver biochemical indicators, but there have been no reports of liver failure caused by this disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmv.26036DOI Listing

TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis.

Ther Adv Respir Dis 2020 Jan-Dec;14:1753466620926800

Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, China.

Increased inflammatory cytokines [such as tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid progression in severe group patients. Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNFα, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1753466620926800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243041PMC

Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemia.

Rev Inst Med Trop Sao Paulo 2020 11;62:e25. Epub 2020 May 11.

Sichuan University, West China Hospital, Department of Laboratory Medicine, Chengdu, China.

Candida is one of the most frequent pathogens of bloodstream infections, which is associated with high morbidity and mortality rates. Rapid immunological detection methods are essential in the early diagnosis of candidemia. Anti-mannan is one of host-derived biomarkers against cell wall components of Candida. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S1678-9946202062025DOI Listing

Comparison of Early Warning Scoring Systems for Hospitalized Patients With and Without Infection at Risk for In-Hospital Mortality and Transfer to the Intensive Care Unit.

JAMA Netw Open 2020 May 1;3(5):e205191. Epub 2020 May 1.

Department of Medicine, University of Chicago, Chicago, Illinois.

Importance: Risk scores used in early warning systems exist for general inpatients and patients with suspected infection outside the intensive care unit (ICU), but their relative performance is incompletely characterized.

Objective: To compare the performance of tools used to determine points-based risk scores among all hospitalized patients, including those with and without suspected infection, for identifying those at risk for death and/or ICU transfer.

Design, Setting, And Participants: In a cohort design, a retrospective analysis of prospectively collected data was conducted in 21 California and 7 Illinois hospitals between 2006 and 2018 among adult inpatients outside the ICU using points-based scores from 5 commonly used tools: National Early Warning Score (NEWS), Modified Early Warning Score (MEWS), Between the Flags (BTF), Quick Sequential Sepsis-Related Organ Failure Assessment (qSOFA), and Systemic Inflammatory Response Syndrome (SIRS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamanetworkopen.2020.5191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237982PMC

Infection-induced innate antimicrobial response disorders: from signaling pathways and their modulation to selected biomarkers.

Cent Eur J Immunol 2020 ;45(1):104-116

Department of Immunology, Biochemistry and Nutrition, Medical University of Warsaw, Warsaw, Poland.

Severe infections are a major public health problem responsible for about 40-65% of hospitalizations in intensive care units (ICU). The high mortality (30-50%) of persons diagnosed with severe infection is caused by largely unknown mechanisms of sepsis-induced immune system response. Severe infections with dynamic progress are accompanied with SIRS (systemic inflammatory reaction syndrome) and CARS (compensatory anti-inflammatory response syndrome), and require a biological treatment appropriate to the phase of immune response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/ceji.2020.94712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226557PMC
January 2020

Cardiovascular phenotypes in ventilated patients with COVID-19 acute respiratory distress syndrome.

Crit Care 2020 05 18;24(1):236. Epub 2020 May 18.

Medical-Surgical Intensive Care Unit, Dupuytren Teaching Hospital, 87000, Limoges, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-020-02958-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234444PMC

The SIRS criteria have better performance for predicting infection than qSOFA scores in the emergency department.

Sci Rep 2020 May 15;10(1):8095. Epub 2020 May 15.

Emergency & Critical Care Center, Kawasaki Municipal Kawasaki Hospital, Kawasaki, Japan.

Systemic inflammatory response syndrome (SIRS) reportedly has a low performance for distinguishing infection from non-infection. We explored the distribution of the patients diagnosed by SIRS (SIRS patients) or a quick sequential organ failure assessment (qSOFA) (qSOFA patients) and confirmed the performance of the both for predicting ultimate infection after hospital admission. We retrospectively analyzed the data from a multicenter prospective study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-64314-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228957PMC

Therapeutic plasma exchange as a routine therapy in septic shock and as an experimental treatment for COVID-19: we are not sure.

Crit Care 2020 05 15;24(1):226. Epub 2020 May 15.

ICU Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Place Van Gehuchtenplein, 4, 1020, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-020-02943-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228434PMC

The Marker of Tubular Injury, Kidney Injury Molecule-1 (KIM-1), in Acute Kidney Injury Complicating Acute Pancreatitis: A Preliminary Study.

J Clin Med 2020 May 13;9(5). Epub 2020 May 13.

Jagiellonian University Medical College, Faculty of Medicine, Chair of Clinical Biochemistry, Department of Diagnostics, 31-501 Kraków, Poland.

Acute pancreatitis (AP) may be associated with severe inflammation and hypovolemia leading to organ complications including acute kidney injury (AKI). According to current guidelines, AKI diagnosis is based on dynamic increase in serum creatinine, however, creatinine increase may be influenced by nonrenal factor and appears late following kidney injury. Kidney injury molecule-1 (KIM-1) is a promising marker of renal tubular injury and it has not been studied in AP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm9051463DOI Listing

ARDS and Massive Pulmonary Embolism: The Combined Use of Extracorporeal Membrane Oxygenation (ECMO) with Thrombolytics.

Case Rep Crit Care 2020 28;2020:1032629. Epub 2020 Apr 28.

Departments of Emergency Medicine and Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Pancreatitis causes a systemic inflammatory response that can lead to acute respiratory distress syndrome (ARDS). We present a case of severe ARDS complicated by a pulmonary embolism (PE) in a 39-year-old female that developed rapidly progressive pancreatitis secondary to hypertriglyceridemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/1032629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204351PMC

Reevaluation of Lung Injury in TNF-Induced Shock: The Role of the Acid Sphingomyelinase.

Mediators Inflamm 2020 1;2020:3650508. Epub 2020 May 1.

Institute of Immunology, Christian-Albrechts University, Arnold-Heller-Str. 3, 24105 Kiel, Germany.

Tumor necrosis factor (TNF) is a well-known mediator of sepsis. In many cases, sepsis results in multiple organ injury including the lung with acute respiratory distress syndrome (ARDS). More than 20-year-old studies have suggested that TNF may be directly responsible for organ injury during sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/3650508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211256PMC

COVID-19 and the role of chronic inflammation in patients with obesity.

Int J Obes (Lond) 2020 May 14. Epub 2020 May 14.

Obesity Center NRW, Sana Kliniken Germany, Huerth, Germany.

Coronavirus disease 2019 (COVID-19) and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a particular risk to people living with preexisting conditions that impair immune response or amplify pro-inflammatory response. Low-grade chronic systemic inflammation, common in people with obesity, is associated with the development of atherosclerosis, type 2 diabetes, and hypertension, well known comorbidities that adversely affect the outcomes of patients with COVID-19. Risk stratification based on the Edmonton Obesity Staging System (EOSS), which classifies obesity based on the presence of medical, mental, and/or functional complications rather than on body mass index (BMI), has been shown to be a better predictor of all-cause mortality and it may well be that EOSS stages may better describe the risk of hyperinflammation in patients with COVID-19 infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41366-020-0597-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224343PMC

Effects of umbelliferone isolated from the Ferulago pauciradiata Boiss. & Heldr. Plant on cecal ligation and puncture-induced sepsis model in rats.

Biomed Pharmacother 2020 May 4;127:110206. Epub 2020 May 4.

Department of Anesthesia, Regional Education and Research Hospital, Erzurum, 25240, Turkey. Electronic address:

Sepsis is a pathophysiological event involving systemic inflammatory response syndrome, multiple organ failure syndromes, and tissue damage. Overproduction of free radicals as a result of tissue damage during sepsis contributes to cellular toxicity, organ failure, and even mortality. Antioxidants, which scavenge free radicals, play a protective role against various diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2020.110206DOI Listing

COVID-19, MERS and SARS with Concomitant Liver Injury-Systematic Review of the Existing Literature.

J Clin Med 2020 May 11;9(5). Epub 2020 May 11.

Department of Gastroenterology, Pomeranian Medical University, 71-252 Szczecin, Poland.

The novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection has been predominantly linked to respiratory distress syndrome, but gastrointestinal symptoms and hepatic injury have also been reported. The mechanism of liver injury is poorly understood and may result as a consequence of viral hepatitis, systemic inflammatory response, gut barrier and microbiome alterations, intensive care treatment or drug toxicity. The incidence of hepatopathy among patients with coronavirus disease 2019 (COVID-19) is unclear, but studies have reported liver injury in patients with SARS and Middle East respiratory syndrome (MERS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm9051420DOI Listing

Drug-Resistant Bacteremia after Fecal Microbiota Transplant. Reply.

N Engl J Med 2020 05;382(20):1961-1962

Massachusetts General Hospital, Boston, MA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc2002496DOI Listing

Drug-Resistant Bacteremia after Fecal Microbiota Transplant.

N Engl J Med 2020 05;382(20):1961

Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc2002496DOI Listing

Drug-Resistant Bacteremia after Fecal Microbiota Transplant.

N Engl J Med 2020 05;382(20):1960-1961

Chang Gung Memorial Hospital, Taoyuan, Taiwan

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc2002496DOI Listing
May 2020
55.873 Impact Factor

Drug-Resistant Bacteremia after Fecal Microbiota Transplant.

N Engl J Med 2020 05;382(20):1960

Mount Sinai Hospital, Toronto, ON, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc2002496DOI Listing

Recommendations from the Sociedade Portuguesa de Cuidados Intensivos and Infection & Sepsis Group for intensive care approach to COVID-19.

Rev Bras Ter Intensiva 2020 Mar 8;32(1):2-10. Epub 2020 May 8.

Sociedade Portuguesa de Cuidados Intensivos, Lisboa, Portugal.

Current COVID-19 epidemics was declared on December 31, 2019 at the Wuhan city seafood market, rapidly spreading throughout China, and later reaching several countries (mainly South Korea, Japan, Italy and Iran) and, since March 1, reaching Portugal. Most of the infected patients present with mild symptoms, not requiring hospitalization. Among those admitted to the hospital, 6% to 10% require admission to the intensive care unit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5935/0103-507x.20200002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206952PMC

COVID-19: Updated Data and its Relation to the Cardiovascular System.

Authors:
Filipe Ferrari

Arq Bras Cardiol 2020 May 11. Epub 2020 May 11.

Programa de Pós-Graduação em Cardiologia e Ciências Cardiovasculares, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

In December 2019, a new human coronavirus, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19) by the World Health Organization, emerged in the city of Wuhan, China. Spreading globally, it is now considered pandemic, with approximately 3 million cases worldwide at the end of April. Its symptoms include fever, cough, and headache, but the main one is shortness of breath. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.36660/abc.20200215DOI Listing

Post-Implantation Syndrome: the impact of different devices for endovascular abdominal aortic aneurysm repair and related etiopathogenetic implications.

Int Angiol 2020 May 13. Epub 2020 May 13.

Vascular Surgery Department, Umberto I Hospital, "Sapienza" University of Rome, Rome, Italy -

Background: Postimplantation syndrome (PIS) is a systemic inflammatory response occurring in early phase after abdominal aortic aneurysm (AAA) endovascular repair (EVAR). PIS can also occur after endovascular aneurysm sealing (EVAS) with Nellix system which prevent new onset of mural thrombus inside. Aim was to compare the incidence of PIS after EVAS and EVAR in order to evaluate the possible role of the new-onset thrombus inside the aneurysmal sac. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23736/S0392-9590.20.04163-2DOI Listing

Early Guillain-Barré syndrome in coronavirus disease 2019 (COVID-19): a case report from an Italian COVID-hospital.

Neurol Sci 2020 May 12. Epub 2020 May 12.

Neurology Unit, Rovereto Hospital, Azienda Provinciale per i Servizi Sanitari (APSS) di Trento, Trento, Italy.

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy associated with dysimmune processes, often related to a previous infectious exposure. During Italian severe acute respiratory syndrome coronavirus-2 outbreak, a woman presented with a rapidly progressive flaccid paralysis with unilateral facial neuropathy after a few days of mild respiratory symptoms. Coronavirus was detected by nasopharyngeal swab, but there was no evidence of its presence in her cerebrospinal fluid, which confirmed the typical albumin-cytological dissociation of GBS, along with consistent neurophysiological data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10072-020-04449-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216127PMC

SARS-CoV-2 Inflammatory Syndrome. Clinical Features and Rationale for Immunological Treatment.

Int J Mol Sci 2020 May 10;21(9). Epub 2020 May 10.

Systemic Rheumatic and Autoimmune Diseases Unit, Department of Biomedical Science and Human Oncology (DIMO), University of Bari Medical School, Piazza G. Cesare 11, I-70124 Bari, Italy.

The current pandemic coronavirus, SARS-CoV-2, is a global health emergency because of its highly contagious nature, the great number of patients requiring intensive care therapy, and the high fatality rate. In the absence of specific antiviral drugs, passive prophylaxis, or a vaccine, the treatment aim in these patients is to prevent the potent virus-induced inflammatory stimuli from leading to the acute respiratory distress syndrome (ARDS), which has a severe prognosis. Here, the mechanism of action and the rationale for employing immunological strategies, which range from traditional chemically synthesized drugs, anti-cytokine antibodies, human immunoglobulin for intravenous use, to vaccines, are reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21093377DOI Listing

Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and Autoimmunity.

Int J Mol Sci 2020 May 8;21(9). Epub 2020 May 8.

Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, 00182 Rome, Italy.

On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency. Typical manifestations consist of flu-like symptoms such as fever, cough, fatigue, and dyspnea. However, in about 20% of patients, the infection progresses to severe interstitial pneumonia and can induce an uncontrolled host-immune response, leading to a life-threatening condition called cytokine release syndrome (CRS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21093330DOI Listing

Cardiovascular-renal axis disorder and acute-phase proteins in cats with congestive heart failure caused by primary cardiomyopathy.

J Vet Intern Med 2020 May 12;34(3):1078-1090. Epub 2020 May 12.

Department of Clinical Sciences, Ross University School of Veterinary Medicine, Basseterre, St Kitts and Nevis.

Background: Currently, the pathogenesis of congestive heart failure (CHF) in cats is not fully understood.

Objective: To identify novel biomarkers for CHF in cats caused by primary cardiomyopathy, particularly related to cardiovascular-renal axis disorder and systemic inflammatory response.

Animals: Twenty-five cats in CHF caused by primary cardiomyopathy, 12 cats with preclinical cardiomyopathy, and 20 healthy controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jvim.15757DOI Listing

Prognostic value of plasma mitochondrial DNA in acute respiratory distress syndrome (ARDS): a single-center observational study.

J Thorac Dis 2020 Apr;12(4):1320-1328

Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.

Background: Mitochondrial DNA (mtDNA) has been reported to play a critical role in the progression of systemic inflammatory response syndrome (SIRS). The pathophysiology of acute respiratory distress syndrome (ARDS) is mainly attributed to the diffuse injury of alveolar epithelial cells caused by dysregulated inflammation upon direct or indirect insults. We hypothesized that plasma mtDNA may serve as an early biomarker that can predict the outcome of patients with ARDS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/jtd.2020.02.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212167PMC

[Clinical observation of 6 severe COVID-19 patients treated with plasma exchange or tocilizumab].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2020 May;49(2):227-231

Department of Respiratory Medicine, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui Province, China.

Objective: To observe the clinical effect of plasma exchange and tocilizumab in treatment of patients with severe coronavirus disease 2019 (COVID-19).

Methods: Six patients with severe COVID-19 admitted in First Affiliated Hospital of Bengbu Medical College from January 25 to February 25, 2020. Three patients were treated with plasma exchange and three patients were treated with tocilizumab. Read More

View Article

Download full-text PDF

Source

Monocyte distribution width enhances early sepsis detection in the emergency department beyond SIRS and qSOFA.

J Intensive Care 2020 5;8:33. Epub 2020 May 5.

7Beckman Coulter, Inc., Miami, FL USA.

Background: The initial presentation of sepsis in the emergency department (ED) is difficult to distinguish from other acute illnesses based upon similar clinical presentations. A new blood parameter, a measurement of increased monocyte volume distribution width (MDW), may be used in combination with other clinical parameters to improve early sepsis detection. We sought to determine if MDW, when combined with other available clinical parameters at the time of ED presentation, improves the early detection of sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40560-020-00446-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201542PMC

Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D.

Front Physiol 2020 22;11:363. Epub 2020 Apr 22.

Division of Lymphatic Biology, Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX, United States.

The metabolic consequences of obesity arise from local inflammation within expanding adipose tissue. In pre-clinical studies targeting various inflammatory factors, systemic metabolism can be improved through reduced adipose inflammation. Lymphatic vessels are a critical regulator of inflammation through roles in fluid and macromolecule transport and immune cell trafficking and immunomodulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2020.00363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188984PMC

Temporal trend and survival impact of infection source among patients with sepsis: a nationwide study.

Crit Care Resusc 2020 Jun;22(2):126-132

Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Background: To determine the temporal trends of incidence and outcome based on different sources of sepsis using a nationwide administrative database.

Methods: From 2002 to 2012, the entire Taiwan's health insurance claims data of emergency-treated and hospital-treated sepsis were analysed for incidence and mortality trends. The information about patients with sepsis and sources of sepsis was identified using a set of validated International Classification of Diseases, ninth revision, clinical modification (ICD-9-CM) codes. Read More

View Article

Download full-text PDF

Source

Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

Cancer Metastasis Rev 2020 May 8. Epub 2020 May 8.

Department of Entomology and Nematology, and UCD Comprehensive Cancer Center, University of California, Davis, Davis, CA, 95616, USA.

Severe coronavirus disease (COVID-19) is characterized by pulmonary hyper-inflammation and potentially life-threatening "cytokine storms". Controlling the local and systemic inflammatory response in COVID-19 may be as important as anti-viral therapies. Endogenous lipid autacoid mediators, referred to as eicosanoids, play a critical role in the induction of inflammation and pro-inflammatory cytokine production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10555-020-09889-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207990PMC

The Society for Immunotherapy of Cancer perspective on regulation of interleukin-6 signaling in COVID-19-related systemic inflammatory response.

J Immunother Cancer 2020 05;8(1)

Istituto Nazionale Tumori IRCCS Fondazione 'G. Pascale', Napels, Italy

The pandemic caused by the novel coronavirus SARS-CoV-2 has placed an unprecedented burden on healthcare systems around the world. In patients who experience severe disease, acute respiratory distress is often accompanied by a pathological immune reaction, sometimes referred to as 'cytokine storm'. One hallmark feature of the profound inflammatory state seen in patients with COVID-19 who succumb to pneumonia and hypoxia is marked elevation of serum cytokines, especially interferon gamma, tumor necrosis factor alpha, interleukin 17 (IL-17), interleukin 8 (IL-8) and interleukin 6 (IL-6). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jitc-2020-000930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211108PMC

COVID-19 and ECMO: the interplay between coagulation and inflammation-a narrative review.

Crit Care 2020 05 8;24(1):205. Epub 2020 May 8.

Cardio-Thoracic Surgery Department Heart and Vascular Centre, Maastricht University Medical Centre, Maastricht, the Netherlands.

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presently become a rapidly spreading and devastating global pandemic. Veno-venous extracorporeal membrane oxygenation (V-V ECMO) may serve as life-saving rescue therapy for refractory respiratory failure in the setting of acute respiratory compromise such as that induced by SARS-CoV-2. While still little is known on the true efficacy of ECMO in this setting, the natural resemblance of seasonal influenza's characteristics with respect to acute onset, initial symptoms, and some complications prompt to ECMO implantation in most severe, pulmonary decompensated patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-020-02925-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209766PMC

Tryptophan pathway catabolites (serotonin, 5-hydroxyindolacetic acid, kynurenine) and enzymes (monoamine oxidase and indole amine 2,3 dioxygenase) in patients with septic shock: A prospective observational study versus healthy controls.

Medicine (Baltimore) 2020 May;99(19):e19906

Service de Biologie médicale, unité de Pharmacologie, Centre Hospitalier de Versailles, Le Chesnay, France.

Septic shock is associated with a strong inflammatory response that induces vasodilation and vascular hyporeactivity. We investigated the role for tryptophan-pathway catabolites of proinflammatory cytokines in septic shock.We prospectively included 30 patients with very recent-onset septic shock and 30 healthy volunteers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000019906DOI Listing

Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy.

Eur Heart J 2020 05;41(19):1821-1829

Institute of Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.

Aims: To compare demographic characteristics, clinical presentation, and outcomes of patients with and without concomitant cardiac disease, hospitalized for COVID-19 in Brescia, Lombardy, Italy.

Methods And Results: The study population includes 99 consecutive patients with COVID-19 pneumonia admitted to our hospital between 4 March and 25 March 2020. Fifty-three patients with a history of cardiac disease were compared with 46 without cardiac disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/eurheartj/ehaa388DOI Listing

Glucocorticoids limit lipopolysaccharide-induced lethal inflammation by a double control system.

EMBO Rep 2020 May 8:e49762. Epub 2020 May 8.

VIB Center for Inflammation Research, Ghent, Belgium.

Lipopolysaccharides (LPS) can lead to a lethal endotoxemia, which is a systemic inflammatory response syndrome (SIRS) characterized by a systemic release of cytokines, such as TNF. Endotoxemia is studied intensely, as a model system of Gram-negative infections. LPS- and TNF-induced SIRS involve a strong induction of interferon-stimulated genes (ISGs), some of which cause cell death in the intestinal epithelium cells (IECs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embr.201949762DOI Listing

Soluble CD14 Subtype in Peripheral Blood is a Biomarker for Early Diagnosis of Sepsis.

Lab Med 2020 May 8. Epub 2020 May 8.

Department of Pediatrics, Shengzhou People's Hospital (the First Affiliated Hospital of Zhejiang University Shengzhou Branch), Shaoxing, Zhejiang, China.

Objective: To study the value of serum soluble CD14 subtype (sCD14-ST) in early diagnosis of sepsis.

Methods: Seventy-two patients were diagnosed with systemic inflammatory response syndrome, sepsis, or septic shock. Peripheral blood was collected at 0, 12, 24, and 48 hours after admission to the hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/labmed/lmaa015DOI Listing

Risk Factors and Outcome of Polymicrobial Bacteremia: A Retrospective Cohort Study.

Isr Med Assoc J 2020 May;22(5):279-284

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Recent data regarding polymicrobial bacteremia (PMB) are lacking.

Objectives: To characterize risk factors as well as clinical, microbiological, and prognostic patterns of patients with PMB in a modern hospital setting.

Methods: A single center retrospective study including all patients diagnosed with PMB during 2013 was conducted. Read More

View Article

Download full-text PDF

Source

Evaluation of asymmetric dimethylarginine as an inflammatory and prognostic marker in dogs with acute pancreatitis.

J Vet Intern Med 2020 May 7;34(3):1144-1149. Epub 2020 May 7.

Veterinary Teaching Hospital "Mario Modenato," Department of Veterinary Sciences, University of Pisa, Pisa, Italy.

Background: Asymmetric dimethylarginine (ADMA) has been proposed as a severity marker in humans with acute pancreatitis (AP).

Objectives: To evaluate ADMA in dogs with AP compared with healthy dogs and its association with severity of disease, mortality, and indicators of the systemic inflammatory response syndrome (SIRS), including serum C-reactive protein (CRP) concentration, WBC count, and band neutrophils.

Animals: Fifty-four dogs with AP and a control group (CG) of 28 healthy dogs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jvim.15785DOI Listing

COVID-19 - Toward a comprehensive understanding of the disease.

Cardiol J 2020 7;27(2):99-114. Epub 2020 May 7.

1st Department of Cardiology, University Catheterization Laboratories, Medical University of Gdansk, Poland.

The evidence on the pathophysiology of the novel coronavirus SARS-CoV-2 infection is rapidly growing. Understanding why some patients suffering from COVID-19 are getting so sick, while others are not, has become an informal imperative for researchers and clinicians around the globe. The answer to this question would allow rationalizing the fear surrounding this pandemic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5603/CJ.a2020.0065DOI Listing

Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: A comprehensive review.

Autoimmun Rev 2020 May 3:102569. Epub 2020 May 3.

Systemic Autoimmune Research Unit, Vall d'Hebron Research Institute, Barcelona, Spain.

Severe Acute Respiratory Syndrome related to Coronavirus-2 (SARS-CoV-2), coronavirus disease-2019 (COVID-19) may cause severe illness in 20% of patients. This may be in part due to an uncontrolled immune-response to SARS-CoV-2 infection triggering a systemic hyperinflammatory response, the so-called "cytokine storm". The reduction of this inflammatory immune-response could be considered as a potential therapeutic target against severe COVID-19. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2020.102569DOI Listing

Prediction of mortality after evacuation of supratentorial intracerebral hemorrhage using NSQIP data.

J Clin Neurosci 2020 May 3. Epub 2020 May 3.

Department of Neurosurgery. State University of New York Upstate Medical University. Syracuse, NY, USA.

Spontaneous intracerebral hemorrhage (sICH) is associated with high rates of morbidity and mortality. Neurosurgical clot evacuation is controversial but often a life saving maneuver in the setting of severe mass effect and cerebral herniation. Outcomes from large multicenter databases are sparsely reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jocn.2020.04.118DOI Listing

Low dose lung radiotherapy for COVID-19 pneumonia. The rationale for a cost-effective anti-inflammatory treatment.

Clin Transl Radiat Oncol 2020 Jul 25;23:27-29. Epub 2020 Apr 25.

Dept Radiation Oncology, Hospital Universitario San Roque, Las Palmas Gran Canaria, Spain.

The COVID-19 pandemia is affecting people worldwide. Most of the patients suffered of a respiratory disease that will progress to an acute respiratory distress syndrome (ARDS). SARS-CoV-2 pneumonia severely ill patients, develop a systemic inflammatory response with a Cytokine Release Syndrome (CRS), that is characterized by a sudden increase in several pro-inflammatory cytokines, mainly IL-1, IL-6 and TNF-alfa by activated macrophages (M1 phenotype). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ctro.2020.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193092PMC

Accelerated Biologic Aging, Chronic Stress, and Risk for Sepsis and Organ Failure Following Trauma.

J Trauma Nurs 2020 May/Jun;27(3):131-140

College of Nursing, Augusta University, Augusta, Georgia (Dr NeSmith); and Medical College of Georgia, Augusta University, Augusta, Georgia (Drs Medeiros, Holsten, Zhu, Looney, and Dong).

Chronic stress and accelerated aging have been shown to impact the inflammatory response and related outcomes like sepsis and organ failure, but data are lacking in the trauma literature. The purpose of this study was to investigate potential relationships between pretrauma stress and posttrauma outcomes. The hypothesis was that pretrauma chronic stress accelerates aging, which increases susceptibility to posttrauma sepsis and organ failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JTN.0000000000000501DOI Listing

Pulmonary complications following cardiac surgery.

Arch Med Sci Atheroscler Dis 2019 31;4:e280-e285. Epub 2019 Dec 31.

Department of Cardiology, Yazd Cardiovascular Research Centre, Shahid Sadoughi University of Medical sciences, Yazd, Iran.

Coronary heart disease is a common diseases of atherosclerosis. Despite the development of noninvasive therapies and the advancement of pharmacological methods and extensive drug regimens, coronary artery bypass grafting surgery is still the ultimate treatment option in many patients. Among the various complications following open heart surgery, one of the common difficulties is pulmonary complications associated with subsequent morbidity and mortality, which should be studied according to preoperative, perioperative, and postoperative factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/amsad.2019.91432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191937PMC
December 2019