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    Melanoma in situ and syringoma: a rare collision tumor. Clinical-pathological report of a case.
    An Bras Dermatol 2017 ;92(5 Suppl 1):101-103
    Department of Dermatology. Hospital Universitari Sagrat Cor, Barcelona, Spain.
    Collision or contiguous tumors, defined as two or more distinct tumors occurring at one site, are often an unexpected finding and may represent a diagnostic challenge, as clinical and histological presentations do not always coincide. Various combinations of collision tumors have been described with respect to melanocytic lesions, with the most frequently reported being the combination of nevus and basal cell carcinoma. We present an unusual case on the nose involving a melanoma in situ and a clinically-inapparent syringoma, which, to the best of our knowledge, is the first report of this combination. Read More

    Malignant cutaneous mixed tumor with sebaceous differentiation.
    Rom J Morphol Embryol 2017 ;58(3):977-982
    Servicio de Anatomia Patologica, Hospital El Bierzo, Ponferrada, Spain;
    Malignant cutaneous mixed tumor (CMT) is a very rare adnexal tumor with biphasic differentiation. In rare cases, a benign CMT (chondroid syringoma) undergoes malignant transformation. Sebaceous differentiation in a cutaneous malignant mixed tumor has not been previously reported. Read More

    Plaque-Type Syringoma: A Case Report.
    Case Rep Dermatol 2017 Sep-Dec;9(3):190-193. Epub 2017 Oct 4.
    Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Syringomas are benign appendageal tumors originated from eccrine ducts. The lesions usually present as multiple small, firm papules at lower eyelids and cheeks of women. Plaque-type syringoma is an infrequent form of syringoma and to date, 12 cases have been reported. Read More

    Microcystic adnexal carcinoma of the orbit mimicking pagetoid sebaceous gland carcinoma.
    Orbit 2017 Oct 20:1-3. Epub 2017 Oct 20.
    d Medical Director, MN Eye Hospital , Chennai , India.
    Microcystic adnexal carcinoma (MAC) is a rare malignancy of sweat glands that has been reported most often on the face in the form of a cutaneous lesion, with the potential for deeper invasion. The synonyms of MAC include sclerosing sweat duct carcinoma, syringomatous carcinoma, and malignant syringoma. Clinically, MAC in the periocular area has been misdiagnosed as basal cell carcinoma, squamous cell carcinoma, or even chalazia. Read More

    Coexistence of eruptive syringoma and bilateral nipple vitiligo: Could there be a common immunopathogenesis?
    North Clin Istanb 2017 26;4(2):195-198. Epub 2017 Aug 26.
    Department of Pathology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
    The rarely seen eruptive syringoma (ES) is characterized by small, skin-colored, papules. Lesions are benign; however, treatment is often unsuccessful. Recent studies have a suggested role of the autoimmune response, rather than reactive proliferation of acrosyringium in the pathogenesis of ES. Read More

    Malignant chondroid syringoma of thigh with late metastasis to lung: A very rare case report.
    Indian J Pathol Microbiol 2017 Jul-Sep;60(3):418-420
    Department of Surgical Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
    Mixed/biphasic tumors include epithelial-myoepithelial tumors, pleomorphic adenoma, matrix-producing tumors, cutaneous mixed tumors such as chondroid syringoma (CS), malignant mixed tumors (carcinosarcomas), pulmonary blastomas (in lung), and many others. Morphology may show overlap between various mixed tumors. At any particular site, whether these tumors are primary or metastasis from other sites is difficult to determine, more so if primary is unknown or not disclosed. Read More

    Syringocystadenoma Papilliferum of Sweat Gland of Caruncle: A Unique Case Report.
    Middle East Afr J Ophthalmol 2017 Apr-Jun;24(2):103-105
    Department of Ophthalmology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.
    Syringocystadenoma papilliferum (SP) is a rare benign hamartomatous malformation of skin which arises from apocrine or eccrine sweat glands. Skin of the head and neck is the usual site for this but rarely involves the eyelids. It is also called as a childhood tumor since it usually appears at birth or during puberty. Read More

    Chondroid Syringoma on Face.
    Arch Craniofac Surg 2016 Sep 23;17(3):173-175. Epub 2016 Sep 23.
    Department of Pathology, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea.
    Chondroid syringoma is a rare mixed tumor of the skin which is composed of both mesenchymal and epithelial cells. Its incidence at less than 0.1% and is frequently located on the head and neck. Read More

    Chondroid Syringoma: Fine-needle Aspiration Cytology of a Rare Entity at an Unusual Site.
    J Clin Diagn Res 2017 Jul 1;11(7):ED06-ED07. Epub 2017 Jul 1.
    Specialist, Department of Pathology, ESIC Hospital, Rohini, New Delhi, India.
    Chondroid syringoma, also known as benign mixed tumour of the skin, is a rare benign adnexal tumour. It is a biphasic tumour, composed of both epithelial and mesenchymal components and constitutes <0.01% of all primary skin tumours. Read More

    Case of chondroid syringoma mimicking a nodular hidradenoma: A diagnostic pitfall on cytopathology.
    Diagn Cytopathol 2018 Jan 3;46(1):59-62. Epub 2017 Aug 3.
    Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, New Delhi, India.
    Limited literature is available on the use of fine needle aspiration (FNA) for skin tumors. Awareness of cytological features of these lesions is important to prevent misdiagnosis. A 45-year-old male, presented with slowly growing swelling over the thigh since 4 years. Read More

    Microcystic Adnexal Carcinoma: A Review of the Literature.
    Dermatol Surg 2017 Aug;43(8):1012-1016
    *Division of Dermatology, Department of Internal Medicine, Washington University, St. Louis, Missouri; †Department of Pathology and Immunology, Washington University, St. Louis, Missouri.
    Background: Microcystic adnexal carcinoma (MAC) is a rare, locally aggressive cutaneous neoplasm that commonly occurs on the face.

    Objective: The purpose of this article is to comprehensively review the current literature on MAC pertaining to epidemiology, pathogenesis, clinical presentation, histology, immunohistochemistry, prognosis, follow-up, and treatment.

    Materials And Methods: An extensive literature review was conducted using OVID MEDLINE and PubMed to identify articles relating to MAC. Read More

    Chondroid Syringoma of a Cheek.
    J Craniofac Surg 2017 Jul;28(5):e480-e481
    Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University, Cheonan, Korea.
    Chondroid syringoma is an unusual, benign skin appendageal tumor originating from the eccrine and apocrine sweat glands resembling mixed tumors of the salivary glands. It develops as a slow-enlarging, small, cutaneous nodule or mass. The lesions are usually seen in older men on head and neck. Read More

    Syringoid Eccrine Carcinoma of the Foot: Report of a Rare Cutaneous Adnexal Neoplasm.
    Int J Surg Pathol 2017 Oct 29;25(7):659-664. Epub 2017 May 29.
    1 Hartford Hospital, Hartford, CT, USA.
    Syringoid eccrine carcinoma is a rare malignant adnexal tumor that typically presents in the head and neck region. Involvement of the extremities is uncommon, with only a few cases reported in the literature. Here, we report our experience with a rare case of syringoid eccrine carcinoma occurring on the plantar surface of the right foot in a 47-year-old African American woman. Read More

    Angiotropic syringomatous carcinoma.
    J Cutan Pathol 2017 Apr 7;44(4):397-400. Epub 2017 Feb 7.
    Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.
    Syringomatous carcinoma (SC) is a slow-growing malignant skin tumor that usually affects the face or scalp. An 83-year-old female developed SC on the sole, a rare location. Histopathologically, numerous ducts with few keratinizing cysts were seen in the upper dermis, and cords, strands and nests with sclerotic stroma were seen in the deep dermis and subcutis. Read More

    Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis.
    J Cutan Pathol 2017 Mar 2;44(3):292-295. Epub 2017 Feb 2.
    Department of Pathology, Kaiser Permanente, Sunset Medical Center, Los Angeles, California.
    Benign cutaneous mixed tumor (chondroid syringoma) is the cutaneous counterpart of the benign mixed tumor (pleomorphic adenoma) of salivary glands, consisting of both epithelial and mesenchymal elements. The incidence of cutaneous mixed tumor is rare, composing <0.01% of all primary skin tumors. Read More

    Periorbital Syringomas Treated With an Externally Used 1,444 nm Neodymium-Doped Yttrium Aluminum Garnet Laser.
    Dermatol Surg 2017 Mar;43(3):381-388
    *All authors are affiliated with the Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
    Background: The 1,444 nm wavelength is also well absorbed in water making it a possible setting for treatment of cystic lesions such as eccrine hydrocystomas and syringomas.

    Objective: The authors aimed to investigate the efficacy of an externally used 1,444 nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser for the treatment of periorbital syringomas.

    Methods And Materials: Nineteen patients with periorbital syringomas were treated twice with the externally used 1,444 nm Nd:YAG laser at 2-month intervals. Read More

    Coexistence of Adult Onset Eruptive Syringoma and Bilateral Renal Cell Carcinoma: A Case Report.
    Am J Dermatopathol 2017 Jan;39(1):56-58
    Departments of *Dermatology, and †Department of Pathology, Ankara Numune Training and Research Hospital, Ankara,Turkey.
    Eruptive syringoma is an unusual variant of syringoma, which usually presents before or during puberty. It typically occurs in large numbers as multiple yellow-brown-colored papules, which may show spontaneous regression. Because some authors have proposed that it could present as a reactive process of eccrine ducts to an inflammatory reaction caused by an unknown trigger, the exact pathomechanism is still unclear. Read More

    Evaluation of Syringomas by In Vivo Reflectance Confocal Microscopy: A Report of Two Cases.
    Am J Dermatopathol 2017 Nov;39(11):845-848
    *Department of Dermatology, University of São Paulo, São Paulo, Brazil; †Department of Pathology, Hospital Obrero, La Paz, Bolivia; and ‡Department of Pathology, Dental School, University of São Paulo, São Paulo, Brazil.
    Syringomas are benign adnexal tumors that are characterized histologically by the presence of small solid and cystic epithelial structures in the upper half of the reticular dermis. Reflectance confocal microscopy is a noninvasive diagnostic method that enables in vivo visualization of tissues with a resolution that approximates that of conventional histopathology. The use of this method in skin imaging over the past several years has improved dermatological diagnoses, creating the potential for its wide application in such diagnoses, especially for benign and malignant skin tumors. Read More

    Retroauricular Pleomorphic Adenoma Arising from Heterotopic Salivary Gland Tissue.
    Plast Reconstr Surg Glob Open 2016 Sep 23;4(9):e1028. Epub 2016 Sep 23.
    West Virginia University School of Medicine, West Virginia University, Morgantown, W.Va.; Department of Pathology, West Virginia University School of Medicine, Morgantown, W.Va.; and Division of Plastic, Reconstructive and Hand Surgery, West Virginia University School of Medicine, Morgantown, W.Va.
    A 38-year-old woman is described who presented with a slowly growing mass on the posterior aspect of the left ear. Excision and histopathologic evaluation revealed a pleomorphic adenoma (PA) originating from heterotopic salivary gland tissue. Many authors have presented cases of PAs originating from ceruminous glands in the external auditory canal or of so-called chondroid syringoma originating from apocrine and eccrine sweat glands. Read More

    Eccrine Duct Dilation as a Marker of Cicatricial Alopecia.
    Am J Dermatopathol 2017 Sep;39(9):668-671
    Departments of *Pathology, and †Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL; and ‡Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.
    Background: Eccrine duct dilation (EDD) and syringoma-like sweat duct proliferation have been described as reactive changes occurring in a variety of skin conditions. However, extensive evaluation of EDD in scalp biopsies performed for alopecia has not been performed.

    Methods: We retrospectively examined 129 cases of cicatricial alopecia (lichen planopilaris, central centrifugal cicatricial alopecia, and discoid lupus erythematosus) and 130 cases of noncicatricial alopecias (androgenetic alopecia, telogen effluvium, and alopecia areata) for the presence of EDD. Read More

    An unusual presentation of chondroid syringoma.
    Indian J Pathol Microbiol 2016 Jul-Sep;59(3):362-4
    Department of Pathology, KPC Medical College, Kolkata, West Bengal, India.
    Chondroid syringoma (CS) is a rare benign tumor of the sweat gland. It generally presents as a painless, slowly growing, subcutaneous swelling, typically located on the head and neck region. The majority of the cases develop in middle aged and elderly males. Read More

    Characteristics of Eccrine Tumors in a Tertiary Institution: A 5-Year Retrospective Study.
    Skinmed 2016 1;14(3):175-80. Epub 2016 Jun 1.
    Department of Pathology, Yong Loo Lin School of Medicine, National University Health System and National University of Singapore.
    Eccrine tumors are adnexal tumors with a varied clinical presentation and wide histological spectrum. This study aims to consolidate data on the clinical characteristics of eccrine tumors to help improve clinical acumen and management of such tumors. Histopathological records from January 2008 to December 2012 were retrieved. Read More

    Clear-Cell (Reticulated) Transformation of Eyelid Eccrine Sweat Glands.
    Ophthal Plast Reconstr Surg 2017 May/Jun;33(3):e69-e72
    *David G. Cogan Laboratory of Ophthalmic Pathology; and †Ophthalmic Plastic Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A.
    A 24-year-old man with a painful, recurrent left upper eyelid nodule underwent an excision. Histopathologic evaluation disclosed a granulomatous process, most likely in response to a ruptured epidermoid cyst. In the vicinity of the nodule were multiple eccrine sweat glands displaying a curious clear-cell appearance in the adlumenal cells, the first example of such a phenomenon in the eyelids. Read More

    Malignant chondroid syringoma in a West African cancer institute: A case report.
    Int J Surg Case Rep 2016 23;25:137-8. Epub 2016 Jun 23.
    Institut Joliot Curie, Hôpital Aristide Le Dantec, Dakar, Senegal. Electronic address:
    Objective: To report a case of malignant chondroid syringoma, a rare skin tumor at Joliot Curie Cancer Institute in Dakar.

    Results: We report a case of malignant chondroid syringoma of the deltoid and axilla in a 53year old patient. Malignant chondroid syringoma is an extremely rare tumor of the sweat glands. Read More

    Emphasizing the pivotal role of fine-needle aspiration cytology in a case of recurrent malignant chondroid syringoma.
    J Cytol 2016 Apr-Jun;33(2):103-5
    Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.
    Fine-needle aspiration cytology (FNAC) features of malignant chondroid syringoma (MCS) are rarely documented. Here, we report a case of recurrent MCS, highlighting its interesting clinicopathologic features. Initially, we received cytology and histopathology slides (for review) of a 57-year-old woman who had undergone resection for an occipital MCS and later presented with recurrence. Read More

    Giant Chondroid Syringoma of the Lower Eyelid.
    Ophthal Plast Reconstr Surg 2017 Mar/Apr;33(2):e43-e44
    *Department of Ophthalmology, and †L.F. Montgomery Ophthalmic Pathology Laboratory, Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, U.S.A.
    Chondroid syringoma is a benign mixed tumor characterized by sweat gland elements in a cartilaginous stroma. This rare tumor accounts for only 0.01% of all primary skin tumors and occurs only rarely in the periorbital region. Read More

    Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms.
    J Cutan Pathol 2016 Aug 10;43(8):649-56. Epub 2016 Jun 10.
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
    Sebaceous carcinoma is a rare but serious malignancy that may be difficult to diagnose when poorly differentiated. Other epithelial tumors with clear cell change may mimic sebaceous carcinoma. Few useful or specific immunohistochemical markers for sebaceous differentiation are available. Read More

    Syringoma: A clinicopathological study of 244 cases.
    Ann Dermatol Venereol 2016 Aug-Sep;143(8-9):521-8. Epub 2016 Apr 21.
    Clinique dermatologique, faculté de médecine, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France.
    Background: Syringomas are benign tumours of the sweat glands, the most familiar clinical presentation of which is the presence of multiple lesions on the eyelids. The aim of our study was to determine the clinical and histological characteristics of a large series of patients and to examine anatomoclinical correlations.

    Patients And Methods: This was a retrospective study conducted in all of the cases of syringoma analysed at the cutaneous histopathology laboratory in Strasbourg between 1970 and 2008. Read More

    Benign Vulvar Adnexal Tumours - A 5 year Study in a Tertiary Care Hospital.
    J Family Reprod Health 2015 Nov;9(4):199-201
    Department of Pathology, Guru Gobind Singh Medical College, Faridkot, Punjab, India.
    Despite of the fact that the vulva contains a high density of apocrine and anogenital mammary glands in addition to eccrine glands and folliculosebaceous units, the benign vulvar adnexal tumours are rare. Though the varied clinical presentation and diverse histopathological spectrum of vulvar neoplasms has amazed the pathologists, only few studies have been reported in literature. The present five year study consists of only five cases of benign vulvar neoplasms depicting their rarity. Read More

    [Syringomas].
    Ann Dermatol Venereol 2016 Aug-Sep;143(8-9):573-6. Epub 2016 Mar 28.
    Clinique dermatologique, faculté de médecine, hôpitaux universitaires de Strasbourg, BP 426, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Electronic address:

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