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    Chondroid Syringoma of a Cheek.
    J Craniofac Surg 2017 Jun 2. Epub 2017 Jun 2.
    Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University, Cheonan, Korea.
    Chondroid syringoma is an unusual, benign skin appendageal tumor originating from the eccrine and apocrine sweat glands resembling mixed tumors of the salivary glands. It develops as a slow-enlarging, small, cutaneous nodule or mass. The lesions are usually seen in older men on head and neck. Read More

    Syringoid Eccrine Carcinoma of the Foot: Report of a Rare Cutaneous Adnexal Neoplasm.
    Int J Surg Pathol 2017 May 1:1066896917712453. Epub 2017 May 1.
    1 Hartford Hospital, Hartford, CT, USA.
    Syringoid eccrine carcinoma is a rare malignant adnexal tumor that typically presents in the head and neck region. Involvement of the extremities is uncommon, with only a few cases reported in the literature. Here, we report our experience with a rare case of syringoid eccrine carcinoma occurring on the plantar surface of the right foot in a 47-year-old African American woman. Read More

    Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis.
    J Cutan Pathol 2017 Mar 2;44(3):292-295. Epub 2017 Feb 2.
    Department of Pathology, Kaiser Permanente, Sunset Medical Center, Los Angeles, California.
    Benign cutaneous mixed tumor (chondroid syringoma) is the cutaneous counterpart of the benign mixed tumor (pleomorphic adenoma) of salivary glands, consisting of both epithelial and mesenchymal elements. The incidence of cutaneous mixed tumor is rare, composing <0.01% of all primary skin tumors. Read More

    Periorbital Syringomas Treated With an Externally Used 1,444 nm Neodymium-Doped Yttrium Aluminum Garnet Laser.
    Dermatol Surg 2017 Mar;43(3):381-388
    *All authors are affiliated with the Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
    Background: The 1,444 nm wavelength is also well absorbed in water making it a possible setting for treatment of cystic lesions such as eccrine hydrocystomas and syringomas.

    Objective: The authors aimed to investigate the efficacy of an externally used 1,444 nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser for the treatment of periorbital syringomas.

    Methods And Materials: Nineteen patients with periorbital syringomas were treated twice with the externally used 1,444 nm Nd:YAG laser at 2-month intervals. Read More

    Coexistence of Adult Onset Eruptive Syringoma and Bilateral Renal Cell Carcinoma: A Case Report.
    Am J Dermatopathol 2017 Jan;39(1):56-58
    Departments of *Dermatology, and †Department of Pathology, Ankara Numune Training and Research Hospital, Ankara,Turkey.
    Eruptive syringoma is an unusual variant of syringoma, which usually presents before or during puberty. It typically occurs in large numbers as multiple yellow-brown-colored papules, which may show spontaneous regression. Because some authors have proposed that it could present as a reactive process of eccrine ducts to an inflammatory reaction caused by an unknown trigger, the exact pathomechanism is still unclear. Read More

    Evaluation of Syringomas by In Vivo Reflectance Confocal Microscopy: A Report of Two Cases.
    Am J Dermatopathol 2016 Oct 18. Epub 2016 Oct 18.
    *Department of Dermatology, University of São Paulo, São Paulo, Brazil; †Department of Pathology, Hospital Obrero, La Paz, Bolivia; and ‡Department of Pathology, Dental School, University of São Paulo, São Paulo, Brazil.
    Syringomas are benign adnexal tumors that are characterized histologically by the presence of small solid and cystic epithelial structures in the upper half of the reticular dermis. Reflectance confocal microscopy is a noninvasive diagnostic method that enables in vivo visualization of tissues with a resolution that approximates that of conventional histopathology. The use of this method in skin imaging over the past several years has improved dermatological diagnoses, creating the potential for its wide application in such diagnoses, especially for benign and malignant skin tumors. Read More

    Retroauricular Pleomorphic Adenoma Arising from Heterotopic Salivary Gland Tissue.
    Plast Reconstr Surg Glob Open 2016 Sep 23;4(9):e1028. Epub 2016 Sep 23.
    West Virginia University School of Medicine, West Virginia University, Morgantown, W.Va.; Department of Pathology, West Virginia University School of Medicine, Morgantown, W.Va.; and Division of Plastic, Reconstructive and Hand Surgery, West Virginia University School of Medicine, Morgantown, W.Va.
    A 38-year-old woman is described who presented with a slowly growing mass on the posterior aspect of the left ear. Excision and histopathologic evaluation revealed a pleomorphic adenoma (PA) originating from heterotopic salivary gland tissue. Many authors have presented cases of PAs originating from ceruminous glands in the external auditory canal or of so-called chondroid syringoma originating from apocrine and eccrine sweat glands. Read More

    Eccrine Duct Dilation as a Marker of Cicatricial Alopecia.
    Am J Dermatopathol 2016 Sep 26. Epub 2016 Sep 26.
    Departments of *Pathology, and †Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL; and ‡Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.
    Background: Eccrine duct dilation (EDD) and syringoma-like sweat duct proliferation have been described as reactive changes occurring in a variety of skin conditions. However, extensive evaluation of EDD in scalp biopsies performed for alopecia has not been performed.

    Methods: We retrospectively examined 129 cases of cicatricial alopecia (lichen planopilaris, central centrifugal cicatricial alopecia, and discoid lupus erythematosus) and 130 cases of noncicatricial alopecias (androgenetic alopecia, telogen effluvium, and alopecia areata) for the presence of EDD. Read More

    Erythematous papules over the neck: a diagnostic conundrum.
    Dermatol Online J 2016 Aug 15;22(8). Epub 2016 Aug 15.
    Department of Dermatology, Katihar Medical College, Katihar, India.
    Syringomas are common appendageal neoplasms, manifested as skin-colored papules, most commonly distributed over the periorbital region. We describe a patient with syringoma localized over the neck and upper chest. Read More

    An unusual presentation of chondroid syringoma.
    Indian J Pathol Microbiol 2016 Jul-Sep;59(3):362-4
    Department of Pathology, KPC Medical College, Kolkata, West Bengal, India.
    Chondroid syringoma (CS) is a rare benign tumor of the sweat gland. It generally presents as a painless, slowly growing, subcutaneous swelling, typically located on the head and neck region. The majority of the cases develop in middle aged and elderly males. Read More

    Characteristics of Eccrine Tumors in a Tertiary Institution: A 5-Year Retrospective Study.
    Skinmed 2016 1;14(3):175-80. Epub 2016 Jun 1.
    Department of Pathology, Yong Loo Lin School of Medicine, National University Health System and National University of Singapore.
    Eccrine tumors are adnexal tumors with a varied clinical presentation and wide histological spectrum. This study aims to consolidate data on the clinical characteristics of eccrine tumors to help improve clinical acumen and management of such tumors. Histopathological records from January 2008 to December 2012 were retrieved. Read More

    Clear-Cell (Reticulated) Transformation of Eyelid Eccrine Sweat Glands.
    Ophthal Plast Reconstr Surg 2017 May/Jun;33(3):e69-e72
    *David G. Cogan Laboratory of Ophthalmic Pathology; and †Ophthalmic Plastic Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A.
    A 24-year-old man with a painful, recurrent left upper eyelid nodule underwent an excision. Histopathologic evaluation disclosed a granulomatous process, most likely in response to a ruptured epidermoid cyst. In the vicinity of the nodule were multiple eccrine sweat glands displaying a curious clear-cell appearance in the adlumenal cells, the first example of such a phenomenon in the eyelids. Read More

    Malignant chondroid syringoma in a West African cancer institute: A case report.
    Int J Surg Case Rep 2016 23;25:137-8. Epub 2016 Jun 23.
    Institut Joliot Curie, Hôpital Aristide Le Dantec, Dakar, Senegal. Electronic address:
    Objective: To report a case of malignant chondroid syringoma, a rare skin tumor at Joliot Curie Cancer Institute in Dakar.

    Results: We report a case of malignant chondroid syringoma of the deltoid and axilla in a 53year old patient. Malignant chondroid syringoma is an extremely rare tumor of the sweat glands. Read More

    Emphasizing the pivotal role of fine-needle aspiration cytology in a case of recurrent malignant chondroid syringoma.
    J Cytol 2016 Apr-Jun;33(2):103-5
    Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.
    Fine-needle aspiration cytology (FNAC) features of malignant chondroid syringoma (MCS) are rarely documented. Here, we report a case of recurrent MCS, highlighting its interesting clinicopathologic features. Initially, we received cytology and histopathology slides (for review) of a 57-year-old woman who had undergone resection for an occipital MCS and later presented with recurrence. Read More

    Giant Chondroid Syringoma of the Lower Eyelid.
    Ophthal Plast Reconstr Surg 2017 Mar/Apr;33(2):e43-e44
    *Department of Ophthalmology, and †L.F. Montgomery Ophthalmic Pathology Laboratory, Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, U.S.A.
    Chondroid syringoma is a benign mixed tumor characterized by sweat gland elements in a cartilaginous stroma. This rare tumor accounts for only 0.01% of all primary skin tumors and occurs only rarely in the periorbital region. Read More

    Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms.
    J Cutan Pathol 2016 Aug 10;43(8):649-56. Epub 2016 Jun 10.
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
    Sebaceous carcinoma is a rare but serious malignancy that may be difficult to diagnose when poorly differentiated. Other epithelial tumors with clear cell change may mimic sebaceous carcinoma. Few useful or specific immunohistochemical markers for sebaceous differentiation are available. Read More

    Syringoma: A clinicopathological study of 244 cases.
    Ann Dermatol Venereol 2016 Aug-Sep;143(8-9):521-8. Epub 2016 Apr 21.
    Clinique dermatologique, faculté de médecine, université de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France.
    Background: Syringomas are benign tumours of the sweat glands, the most familiar clinical presentation of which is the presence of multiple lesions on the eyelids. The aim of our study was to determine the clinical and histological characteristics of a large series of patients and to examine anatomoclinical correlations.

    Patients And Methods: This was a retrospective study conducted in all of the cases of syringoma analysed at the cutaneous histopathology laboratory in Strasbourg between 1970 and 2008. Read More

    Benign Vulvar Adnexal Tumours - A 5 year Study in a Tertiary Care Hospital.
    J Family Reprod Health 2015 Nov;9(4):199-201
    Department of Pathology, Guru Gobind Singh Medical College, Faridkot, Punjab, India.
    Despite of the fact that the vulva contains a high density of apocrine and anogenital mammary glands in addition to eccrine glands and folliculosebaceous units, the benign vulvar adnexal tumours are rare. Though the varied clinical presentation and diverse histopathological spectrum of vulvar neoplasms has amazed the pathologists, only few studies have been reported in literature. The present five year study consists of only five cases of benign vulvar neoplasms depicting their rarity. Read More

    [Syringomas].
    Ann Dermatol Venereol 2016 Aug-Sep;143(8-9):573-6. Epub 2016 Mar 28.
    Clinique dermatologique, faculté de médecine, hôpitaux universitaires de Strasbourg, BP 426, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Electronic address:

    Syringomas Accentuated on the Upper Lip.
    Pediatr Dermatol 2016 Mar-Apr;33(2):e172-3
    Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    An 8-year-old boy presented with small, skin-colored papules of 9-months duration on the upper lip. Results of the histopathologic examination were consistent with syringoma. To the best of our knowledge, this is the first case report of syringoma of the mustache area of a child. Read More

    Erbium YAG laser treatment of periorbital syringomas by using the multiple ovoid-shape ablation method.
    J Cosmet Laser Ther 2016 Oct 12;18(5):280-5. Epub 2016 May 12.
    a Chitosedai Kitano Clinic , Tokyo , Japan.
    Introduction: Syringomas are benign tumours that develop predominantly in the periorbital areas of women. As periorbital syringoma is adjacent to the appendages, Erbium YAG (Er:YAG) laser treatment should be an ideal tool for its precise ablation, although its use has not previously been reported. We retrospectively analysed our new ovoid-shape Er:YAG laser ablation method for the treatment of syringoma. Read More

    Rare benign mixed tumour of the upper lip: A case report.
    Ann Med Surg (Lond) 2015 Dec 9;4(4):380-3. Epub 2015 Oct 9.
    Barts NHS Foundation Trust, Barts and The London School of Medicine and Dentistry, United Kingdom.
    Background: Chondroid syringomas (CS) are rare benign mixed tumours. Clinical differentiation can be misleading due to the silent presentation, with only histopathological findings confirming the diagnosis.

    Case Report: A 23-year-old Caucasian gentleman presented with an eighteen month history of increasing size of his exophytic upper lip mass. Read More

    Chondroid Syringoma of the Philtral Dimple.
    J Cutan Aesthet Surg 2015 Oct-Dec;8(4):242-4
    Department of General Surgery, Karnataka Institute of Medical Sciences (KIMS), Hubli, Karnataka, India.
    A chondroid syringoma (CS) is an exceedingly rare mixed tumor of the skin. These tumors are relatively common in the head and neck area. Occurrence of these tumors in the philtrum is rare, with only two documented cases in English literature to the best of our knowledge. Read More

    Syringomatous Structures in Extramammary Paget Disease: A Potential Diagnostic Pitfall.
    Am J Dermatopathol 2016 Sep;38(9):653-7
    *Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint Petersburg, Russia; †Department of Pathology, Medical Faculty, Saint-Petersburg State University, Saint Petersburg, Russia; ‡Department of Pathology, BC Cancer Agency, Vancouver, British Columbia, Canada; §Department of Histopathology, King Edward Memorial Hospital, Perth, Australia; ¶Department of Pathology, Division of Dermatopathology, Medical College of Wisconsin, Milwaukee, WI; ‖Sikl's Department of Pathology, Bioptical Laboratory, Pilsen, Czech Republic; **Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; and ††Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Primary extramammary Paget disease (EMPD) is a form of intraepithelial adenocarcinoma. Different morphological changes may accompany EMPD, including the presence of syringoma-like structures. The authors report 10 cases of EMPD, all of which manifested syringoma-like structures within the dermis both in areas involved by the carcinoma and beyond, including at the margins of the excisions. Read More

    Evaluation and management of the patient with multiple syringomas: A systematic review of the literature.
    J Am Acad Dermatol 2016 Jun 3;74(6):1234-1240.e9. Epub 2016 Feb 3.
    Department of Dermatology, University of California San Francisco, San Francisco, California. Electronic address:
    Syringomas are benign adnexal tumors with distinct histopathologic features, including the characteristic comma ("tadpole") shaped tail comprised of dilated, cystic eccrine ducts. Clinically, syringomas typically present in adolescent females predominantly in the periorbital region. They may present as solitary or multiple lesions, and more rare sites of involvement include the genitals, palms, scalp, and the chest. Read More

    Chondroid syringoma of the axilla: An unusual tumor diagnosed by fine needle aspiration.
    Diagn Cytopathol 2016 Apr 22;44(4):342-6. Epub 2016 Jan 22.
    Department of Pathology, New York University Medical Center, New York, New York.
    Chondroid syringoma (CS) is a rare benign adnexal tumor of the skin with a resemblance to pleomorphic adenoma of salivary gland, most commonly involving the head and neck region. In the present literature, reports of the cytologic appearance of CS are scarce as it is rarely encountered by fine needle aspiration (FNA). A 67-year-old woman presented with a 1 year history of a 1 cm subcutaneous nodule in the right axilla. Read More

    Eruptive Penile Syringomas in an Adolescent: Novel Approach with Serial Microexcisions and Suture-Adhesive Repair.
    Pediatr Dermatol 2016 Mar-Apr;33(2):e57-60. Epub 2016 Jan 14.
    Division of Dermatology, Loyola University Medical Center, Maywood, Illinois.
    Penile syringomas are benign adnexal tumors that are usually asymptomatic but can be cosmetically distressing. Because of the delicate nature of skin in this region, treatment is difficult, and there are few case reports of procedural destruction of these tumors. We report a case of successful surgical excision using Castroviejo ophthalmic scissors followed by primary closure with fast-absorbing plain gut suture and a cyanoacrylate adhesive application. Read More

    Syringocystadenoma papilliferum in an unusual location.
    An Bras Dermatol 2015 Nov-Dec;90(6):900-2
    Universidade Federal do Pará, Belém, PA, Brazil.
    Syringocystadenoma papilliferum is a rare benign hamartomatous adnexal tumor of the apocrine or eccrine sweat glands. Most patients present a solitary lesion in the head and neck region. Presentation outside the head and neck region is even more uncommon. Read More

    Eruptive Syringoma in the Elderly: A Case Report.
    Acta Dermatovenerol Croat 2015 ;23(4):289-92
    Marina Vekić Mužević, MD, Osijek University Hospital Center, Josipa Huttlera 3, 31 000 Osijek, Croatia;
    Syringomas are benign tumors of adnexal origin, and eruptive syringoma is an extremely rare subtype. In this paper, we present a case of a unusual occurrence of eruptive syringoma in 66-year old woman that includes clinical and pathohistological findings and the review of the clinical picture, diagnosis, and treatment options. Read More

    A diagnostic challenge.
    Dermatol Online J 2016 Nov 15;22(11). Epub 2016 Nov 15.
    Department of Dermatology, Dudley NHS Foundation Trust, West Midlands, United Kingdom.
    A 74 year-old woman presented with a 9 month history of a slowly enlarging exophytic lesion over her left nasal alar. Examination revealed a firm, cystic mass fixed to underlying skin. It was pedunculated with occasional superficial telangiectasia and a violaceous hue. Read More

    Misdiagnosed microcystic adnexal carcinoma on the lateral forehead and challenges in reconstruction of a large and bone-deep defect.
    J Dtsch Dermatol Ges 2016 Jan;14(1):86-90
    Department of Dermatology, Venereology and Allergology, Academic Teaching Department of Medical University Innsbruck, Central Teaching Hospital Bolzano/Bozen, Italy.
    Background: Microcystic adnexal carcinoma (MAC) is a rare cutaneous malignancy characterized by aggressive local infiltration, including a high propensity for perineural invasion. Histologically it can be easily confused with benign adnexal tumors, which often leads to inappropriate initial treatment. As a consequence delayed surgical excision often requires removal of large cutaneous masses which can be followed by challenges in reconstruction. Read More

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