37,176 results match your criteria Syphilis


Determinants of gonorrhea and syphilis infections among pregnant women attending antenatal clinic at Dilla University Referral Hospital, Ethiopia: Unmatched case-control study.

Womens Health (Lond) 2020 Jan-Dec;16:1745506520940095

School of Public Health, Hawassa University, Hawassa, Ethiopia.

Objective: This study was designed to determine the risk factors associated with gonorrhea and syphilis infections among pregnant women attending antenatal care clinic at Dilla University Referral Hospital.

Method: A hospital-based unmatched case-control study (64 cases and 128 controls) with 1:2 ratios was conducted from 29 January 2018 to 20 June 2018, at the antenatal care clinic of the Dilla University Referral Hospital. Venous blood and vaginal swab were collected to screen for gonorrhea and syphilis. Read More

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http://dx.doi.org/10.1177/1745506520940095DOI Listing

Alterations of CCR2 and CX3CR1 on Three Monocyte Subsets During HIV-1/ Coinfection.

Front Med (Lausanne) 2020 18;7:272. Epub 2020 Jun 18.

Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.

HIV-1/ () coinfection has become a global challenge, and three monocyte subsets express varying levels of the chemokine receptors CCR2 and CX3CR1. We recently evaluated the association between monocyte subsets and regulatory T cells in HIV-infected individuals with syphilis. Currently, the dynamic changes of CCR2 and CX3CR1 on monocyte subsets during HIV-1 and syphilis coinfection have not been fully investigated. Read More

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http://dx.doi.org/10.3389/fmed.2020.00272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314900PMC

Epidemiology, molecular strain types, and macrolide resistance of Treponema pallidum in Japan, 2017-2018.

J Infect Chemother 2020 Jul 2. Epub 2020 Jul 2.

Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.

Background: Japan has seen a substantial increase in syphilis cases since 2013 and Tokyo and Osaka prefectures accounted for about 40% of all cases in Japan. Therefore, focusing on these 2 prefectures, we assessed syphilis cases detected during 2017-2018, combining epidemiological information with molecular typing data.

Methods: Using data from surveillance reports, we described syphilis cases by gender, age, transmission route, and stage of syphilis. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.05.022DOI Listing

Syphilis infection among people who use and inject drugs in Cambodia: a cross-sectional study using the respondent-driven sampling method.

Int J STD AIDS 2020 Jul 5:956462420929132. Epub 2020 Jul 5.

Centre for Global Health Policy, University of Sussex, Brighton, UK.

This cross-sectional study explored the prevalence and correlates of syphilis infection among people who use and inject drugs (PWUD/PWID) in Cambodia. Data were collected in 2017 from 1,677 PWUD/PWID living in the capital city of Phnom Penh and 11 other major provinces using the respondent-driven sampling method. The SD Bioline HIV/Syphilis Duo test was used to determine human immunodeficiency virus (HIV) and current or past syphilis infection. Read More

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http://dx.doi.org/10.1177/0956462420929132DOI Listing

Correlates of trichomoniasis among female sex workers who inject drugs in two Mexico-US border cities.

Int J STD AIDS 2020 Jul 5:956462420929463. Epub 2020 Jul 5.

Department of Medicine, Division of Global Public Health, University of California San Diego, La Jolla, CA, USA.

This paper evaluates correlates of trichomoniasis among female sex workers who inject drugs (FSWIDs) in two Mexico-US border cities. HIV-negative FSWIDs aged 18 years or older were enrolled in a study between 2008 and 2010 in Tijuana and Ciudad Juarez (Cd.), Mexico. Read More

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http://dx.doi.org/10.1177/0956462420929463DOI Listing

METAGENOMIC IDENTIFICATION OF HUMAN GEMYKIBIVIRUS-2 (HuGkV-2) IN PARENTERALLY INFECTED BLOOD DONORS FROM THE BRAZILIAN AMAZON.

Int J Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Regional Blood Center of Ribeirao Preto, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, 14051-140, Brazil. Electronic address:

Objectives: Metagenomic analysis of blood units originating from the Brazilian Amazon and positive for parenterally transmitted infections (HIV, HBV, HCV, HTLV, Chagas disease or syphilis).

Methods: Twenty plasma samples (35% HBV-positive, 10%HIV-positive, 10% HCV-positive, 20% positive for syphilis, 20% for Chagas disease and 5% for HTLV) assembled in pools were analyzed by metagenomic next generation sequencing. The obtained raw sequencing data were submitted to a bioinformatic pipeline set up for identification of emerging viruses. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.096DOI Listing

[Early symptomatic congenital syphilis in a newborn].

An Pediatr (Barc) 2020 Jun 30. Epub 2020 Jun 30.

Servicio de Pediatría, Hospital General de Valencia, Valencia, España. Electronic address:

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http://dx.doi.org/10.1016/j.anpedi.2020.05.012DOI Listing

Surveillance of Antibiotic Resistance Genes in Treponema Pallidum Subspecies Pallidum from Patients with Early Syphilis in France.

Acta Derm Venereol 2020 Jul 3. Epub 2020 Jul 3.

INSERM, Institut Cochin U1016-CNRS UMR8104, Université Sorbonne Paris Descartes, Groupe Hospitalier, Paris, France.

Benzathine penicillin G (BPG) is the reference treatment for early syphilis, but shortages have recently been reported, highlighting a need for the validation of alternative treatments. The aim of this study was to evaluate the genomic resistance of Treponema pallidum subspecies pallidum (TPA) to macrolides and doxycycline in France. Swabs from genital, anal, oral and cutaneous lesions were obtained from 146 patients with early syphilis in France. Read More

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http://dx.doi.org/10.2340/00015555-3589DOI Listing

Prevalence, associated factors and clinical features of congenital syphilis among newborns in Mbarara hospital, Uganda.

BMC Pregnancy Childbirth 2020 Jul 2;20(1):385. Epub 2020 Jul 2.

Mbarara University of Science and Technology, P O Box 1410, Mbarara, Uganda.

Background: While congenital syphilis is a significant public health problem that can cause severe disabilities, little is known about the situation in Uganda. We describe prevalence, associated factors and clinical presentation of congenital syphilis in Mbarara, Uganda.

Methods: A cross sectional study was carried out among mother- newborn dyads from the postnatal ward of Mbarara Regional Referral Hospital (MRRH). Read More

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http://dx.doi.org/10.1186/s12884-020-03047-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330944PMC

Changing demography of genital chlamydia, gonorrhea, genital herpes, condyloma and syphilis infections in Japan.

Jpn J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

National Institute of Infectious Diseases, Japan.

There was epidemiological correlation in time and in space between gonorrhea and genital chlamydia and between condyloma and genital herpes. There was, however, no correlation in other combinations, such as, gonorrhea and condyloma, genital herpes and chlamydia, etc. The annual incidence of gonorrhea and that of genital chlamydia were mono-phasic with a peak in 2005-2006. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2020.005DOI Listing

A Serological Survey of Selected Papua New Guinea Blood Donors for Hepatitis B and Related Co-Infections.

Trop Med Infect Dis 2020 Jun 29;5(3). Epub 2020 Jun 29.

Medical and Veterinary Sciences, College of Public Health, James Cook University, Townsville, Queensland 4811, Australia.

Hepatitis B virus (HBV) infection is a serious problem and earlier studies in Papua New Guinea have reported a high prevalence of hepatitis B virus infection. These studies were undertaken using insensitive tests and before an expanded immunization program. The current HBV status is therefore uncertain. Read More

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http://dx.doi.org/10.3390/tropicalmed5030108DOI Listing

Compensation and reparations for victims and bystanders of the U.S. Public Health Service research studies in Tuskegee and Guatemala: Who do we owe what?

Authors:
Susan M Reverby

Bioethics 2020 Jun 30. Epub 2020 Jun 30.

Women's and Gender Studies Department, Wellesley College, Wellesley, Massachusetts.

Using the infamous research studies in Tuskegee and Guatemala, the article examines the difference between victims and bystanders. The victims can include families, sexual partners, and children not just the participants. There are also the bystanders in the populations who are affected, even vaguely, decades after the initial studies took place. Read More

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http://dx.doi.org/10.1111/bioe.12784DOI Listing

Anti-N-methyl-D-aspartate-receptor antibody encephalitis combined with syphilis: A case report.

World J Clin Cases 2020 Jun;8(12):2603-2609

Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, China.

Background: Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is a common type of autoimmune encephalitis characterized by complex clinical signs and variable imaging manifestations. The pathogenesis of the disease is unclear. Syphilis is an infectious disease caused by that can invade the nervous and immune systems and cause systemic symptoms. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322422PMC

Neurosyphilis revealed by compressive cervical spine syphilitic gumma: a case report.

Spinal Cord Ser Cases 2020 Jun 30;6(1):56. Epub 2020 Jun 30.

Department of Neurosurgery, University Hospital Center Mohammed VI, Faculty of Medicine, Mohammed First University, Oujda, Morocco.

Introduction: Neurosyphilis is a sexually transmitted disease secondary to the invasion of the central nervous system by the Treponema pallidum. The spinal syphilitic gumma is rare.

Case Presentation: We report a case of extradural cervical spinal syphilitic gumma revealed by spinal cord compression in a 58-year-old male. Read More

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http://dx.doi.org/10.1038/s41394-020-0303-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324907PMC

Promoting routine syphilis screening among men who have sex with men in China: study protocol for a randomised controlled trial of syphilis self-testing and lottery incentive.

BMC Infect Dis 2020 Jun 29;20(1):455. Epub 2020 Jun 29.

University of North Carolina Project-China, Guangzhou, Guangdong, China.

Background: Men who have sex with men (MSM) bear a high burden of syphilis infection. Expanding syphilis testing to improve timely diagnosis and treatment is critical to improve syphilis control. However, syphilis testing rates remain low among MSM, particularly in low- and middle-income countries. Read More

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http://dx.doi.org/10.1186/s12879-020-05188-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325146PMC

[Cardiovascular syphilis (current state of the problem and analysis of own observations)].

Ter Arkh 2019 Nov 15;91(11):81-85. Epub 2019 Nov 15.

Novosibirsk State Medical University.

A description of two cases of cardiovascular syphilis is presented. The introduction discusses the relevance of visceral syphilis. The literary review is constructed in a chronological format and reflects the stages of studying the problem of cardiovascular syphilis. Read More

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http://dx.doi.org/10.26442/00403660.2019.11.000246DOI Listing
November 2019

[Analysis of causes of death and etiological characteristics of skin tissue donors].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):446-450

Institute of Burns, Tongren Hospital of Wuhan University & Wuhan Third Hospital, Wuhan Remains (Organs) Donation Registration and Skin Receiving Station, Wuhan 430060, China.

To investigate the causes of death and etiological characteristics of skin tissue donors, and to provide reference for allogeneic skin transplantation. From October 2008 to October 2018, 49 skin tissue donors accepted by the Burn Department of Wuhan Third Hospital met the inclusion criteria of this study, and a cross-sectional study was conducted. According to the cause of death, the donors were divided into accidental death group (19 cases) and non-accidental death group (30 cases). Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190307-00085DOI Listing

Dermatoses of the world: Burden of skin disease and associated socioeconomic status in the world.

J Am Acad Dermatol 2020 Jun 25. Epub 2020 Jun 25.

Apex Dermatology and Skin Surgery Center, Mayfield Heights, OH; Lake Erie College of Osteopathic Medicine, Erie, PA.

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http://dx.doi.org/10.1016/j.jaad.2020.05.157DOI Listing

Low HIV incidence among women following sexually transmitted infection does not support national pre-exposure prophylaxis recommendations.

AIDS 2020 Jul;34(9):1429-1431

Public Health-Seattle & King County HIV/STD Program.

: Current United States guidelines recommend that clinicians offer HIV pre-exposure prophylaxis (PrEP) to women with gonorrhea or syphilis. We estimated HIV incidence among women following a syphilis, gonorrhea, or chlamydia diagnosis among women in King County, WA using surveillance data from 2008 to 2018. Among women with diagnosed with gonorrhea and among women diagnosed with chlamydia the estimated HIV incidence rates were 0. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002561DOI Listing

Impact of continuing education on maternal and child health indicators.

PLoS One 2020 26;15(6):e0235258. Epub 2020 Jun 26.

Faculty of Dentistry, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.

Objective: This study investigated whether the presence of care workers who completed a specialization course on family health was associated with improved care and maternal and child health indicators in municipalities in the state of Mato Grosso do Sul, Brazil.

Methods: Negative binomial regression models with fixed effects were used for the 79 municipalities in the state of Mato Grosso do Sul, with repeated observations for the period 2009-2015. For our reference, the parameter "number of professionals who completed the course" calculated the proportion of professionals who completed the course, and was divided by the total number of primary health care professionals in the municipality to create a ratio. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235258PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319283PMC

Thyroid gland involvement in secondary syphilis: a case report.

Acta Clin Belg 2020 Jun 26:1-5. Epub 2020 Jun 26.

Department of Endocrinology, Hospital AZ Damiaan , Ostend, Belgium.

Background: Syphilis is a systemic, infectious disease caused by and is notorious for the variety of its clinical presentations.

Objective: We report a case of secondary syphilis with thyroid gland and ocular involvement in a human immunodeficiency virus (HIV) negative patient.

Methods: We present the patient's history, clinical findings, laboratory test results, imaging and management. Read More

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http://dx.doi.org/10.1080/17843286.2020.1787635DOI Listing

Social media-based secondary distribution of HIV/syphilis self-testing among Chinese men who have sex with men.

Clin Infect Dis 2020 Jun 26. Epub 2020 Jun 26.

Insititute of Global Health and STI Research, Southern Medical University, Guangzhou, China.

Background: Social media and secondary distribution (distributing self-testing kits by indexes through their networks) both show strong promise to improve HIV self-testing uptake. We assessed an implementation program in Zhuhai, China, which focused on the secondary distribution of HIV/syphilis self-test kits among men who have sex with men (MSM) via social media.

Methods: Men of age 16 or above, born biologically male, and ever had sex with another man were recruited as indexes. Read More

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http://dx.doi.org/10.1093/cid/ciaa825DOI Listing

Stop, think SCORTCH: rethinking the traditional 'TORCH' screen in an era of re-emerging syphilis.

Arch Dis Child 2020 Jun 25. Epub 2020 Jun 25.

Department of Paediatric Infectious Diseases, Imperial College Healthcare NHS Trust, London, UK.

Background: The epidemiology of congenital infections is ever changing, with a recent resurgence in syphilis infection rates seen in the UK. Identification of congenital infection is often delayed; early recognition and management of congenital infections is important. Testing modalities and investigations are often limited, leading to missed diagnostic opportunities. Read More

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http://dx.doi.org/10.1136/archdischild-2020-318841DOI Listing

Barriers to syphilis testing among men who have sex with men: a systematic review of the literature.

Sex Health 2020 Jun;17(3):201-213

University of Maryland, College Park, School of Public Health, Department of Epidemiology and Biostatistics, 4200 Valley Drive #2242, College Park, MD 20742, USA.

Men who have sex with men (MSM) represent the highest risk group for syphilis in the United States and several other countries. Improving uptake of syphilis testing among MSM requires understanding key barriers to testing in this population. Using preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, a systematic review to assess proportions of syphilis testing among MSM and identify social, structural, and individual barriers to syphilis testing was conducted. Read More

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http://dx.doi.org/10.1071/SH19044DOI Listing

Sexual behavior and its association with persistent oral lesions: analysis of the POP-Brazil study.

Clin Oral Investig 2020 Jun 25. Epub 2020 Jun 25.

Hospital Moinhos de Vento. Rua Ramiro Barcelos 910, Porto Alegre, Rio Grande do Sul, 90035-001, Brazil.

Objectives: To investigate whether the presence of persistent self-reported oral lesions (PSOLs) is associated with sexual behaviors and with the presence of sexually transmitted infections (STIs) in individuals aged 16-25 years in the state capitals of Brazil.

Materials And Methods: Data from the POP-Brazil study were analyzed. An association analysis was performed by Poisson regression with the presence of PSOLs as the outcome. Read More

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http://dx.doi.org/10.1007/s00784-020-03407-0DOI Listing

Gastric syphilis and its importance for a differential diagnosis in HIV patients.

Rev Esp Enferm Dig 2020 Jun 24;112. Epub 2020 Jun 24.

Cirugía General y del Aparato Digestivo, Hospital Universitario Doctor Peset, España.

A 41-year-old male, with history of HIV presented to emergency department with two months of abdominal pain and a weight loss. Radiological and endoscopic examinations where suggestive of gastric cancer. However, biopsies ruled out malignancy. Read More

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http://dx.doi.org/10.17235/reed.2020.6729/2019DOI Listing

Evidence Review for Centers for Disease Control and Prevention Guidance Development on Laboratory Testing to Detect Treponema pallidum Infection (Syphilis).

Clin Infect Dis 2020 Jun;71(Supplement_1):S1-S3

Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

The articles in this supplement address key questions on syphilis diagnostics, provide reference tables of test performances, and discuss optimal specimens and knowledge gaps. Laboratory-developed genetic direct detection tests could be most useful at the point of care and add to the currently available serologic methods of nontreponemal and treponemal tests. Read More

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http://dx.doi.org/10.1093/cid/ciaa348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315932PMC

Sensitivity and Specificity of Treponemal-specific Tests for the Diagnosis of Syphilis.

Clin Infect Dis 2020 Jun;71(Supplement_1):S13-S20

Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

We conducted a systematic review of relevant syphilis diagnostic literature to address the question, "What is the sensitivity and specificity of the treponemal tests currently approved by the Food and Drug Administration (FDA) for the diagnosis of syphilis (by stage)?" There were 16 treponemal assays evaluated: 13 immunoassays and 3 manual assays (fluorescent treponemal antibody absorbed test [FTA-ABS], microhemagglutination assay for Treponema pallidum antibodies [MHA-TP], Treponema pallidum particle agglutination assay [TP-PA]). MHA-TP and FTA-ABS were less sensitive in primary and secondary syphilis than TP-PA; TP-PA is the most specific manual treponemal assay. There is insufficient evidence to recommend one particular treponemal immunoassay (eg, enzyme immunoassays, chemiluminescence immunoassays, microbead immunoassays) over another based on published performance data. Read More

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http://dx.doi.org/10.1093/cid/ciaa349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312216PMC

Molecular and Direct Detection Tests for Treponema pallidum Subspecies pallidum: A Review of the Literature, 1964-2017.

Clin Infect Dis 2020 Jun;71(Supplement_1):S4-S12

Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Direct detection methods for Treponema pallidum include dark-field microscopy (DFM), direct fluorescence antibody (DFA) testing, immunohistochemistry (IHC), and nucleic acid amplification tests (NAATs). Here, we reviewed the relevant syphilis diagnostic literature to address 2 main questions with respect to T. pallidum direct detection techniques: "What are the performance characteristics for each direct detection test for T. Read More

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http://dx.doi.org/10.1093/cid/ciaa176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312206PMC

The Traditional or Reverse Algorithm for Diagnosis of Syphilis: Pros and Cons.

Clin Infect Dis 2020 Jun;71(Supplement_1):S43-S51

Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.

We reviewed relevant syphilis diagnostic literature to address the question "What diagnostic considerations should be taken into account when screening for syphilis using the traditional or reverse algorithm?" Improved laboratory diagnosis of syphilis is an important element of the effort to reduce syphilis rates. Screening for syphilis is performed using either a nontreponemal or treponemal test (part of the traditional or reverse algorithm, respectively). Both syphilis algorithms are used by laboratories. Read More

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http://dx.doi.org/10.1093/cid/ciaa307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312234PMC

Clinical Test Performance of a Rapid Point-of-Care Syphilis Treponemal Antibody Test: A Systematic Review and Meta-analysis.

Clin Infect Dis 2020 Jun;71(Supplement_1):S52-S57

District of Columbia Department of Forensic Sciences, Public Health Laboratory Division, Washington, DC, USA.

We reviewed relevant syphilis diagnostic literature and conducted a meta-analysis to address the question, "What is the sensitivity and specificity of the Syphilis Health Check, a rapid qualitative test for the detection of human antibodies to Treponema pallidum." The Syphilis Health Check is the only rapid syphilis test currently cleared by the Food and Drug Administration (FDA). We conducted a systematic review and a meta-analysis using Bayesian bivariate random-effects and fixed-effect models to create pooled estimates of sensitivity and specificity of the Syphilis Health Check. Read More

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http://dx.doi.org/10.1093/cid/ciaa350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312211PMC

Syphilis Laboratory Guidelines: Performance Characteristics of Nontreponemal Antibody Tests.

Clin Infect Dis 2020 Jun;71(Supplement_1):S21-S42

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

We reviewed the relevant syphilis diagnostic literature to address the following question: what are the performance characteristics, stratified by the stage of syphilis, for nontreponemal serologic tests? The database search included key terms related to syphilis and nontreponemal tests from 1960-2017, and for data related to the venereal disease research laboratory test from 1940-1960. Based on this review, we report the sensitivity and specificity for each stage of syphilis (primary, secondary, early latent, late latent, or unknown duration; tertiary as well as neurosyphilis, ocular syphilis, and otic syphilis). We also report on reactive nontreponemal tests in conditions other than syphilis, false negatives, and automated nontreponemal tests. Read More

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http://dx.doi.org/10.1093/cid/ciaa306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312285PMC

Factors associated with sexually transmitted infections in sugarcane cutters: subsidies to caring for.

Rev Lat Am Enfermagem 2020 19;28:e3306. Epub 2020 Jun 19.

Universidade Federal da Paraíba, Departamento de Enfermagem Clínica, João Pessoa, PB, Brazil.

Objective: to estimate the prevalence of Sexually Transmitted Infections (STIs) and associated factors in sugarcane cutters.

Method: a cross-sectional, analytical study with 937 sugarcane cutters from Paraíba and Goiás, states of Brazil, respectively. An outcome variable was the positive results in some rapid tests for HIV, syphilis, hepatitis B and C. Read More

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http://dx.doi.org/10.1590/1518-8345.3425.3306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304989PMC

Investigation of syphilis immunology and Treponema pallidum subsp. pallidum biology to improve clinical management and design a broadly protective vaccine: study protocol.

BMC Infect Dis 2020 Jun 23;20(1):444. Epub 2020 Jun 23.

Division of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.

Background: The syphilis epidemic continues to cause substantial morbidity and mortality worldwide, particularly in low- and middle-income countries, despite several recent disease control initiatives. Though our understanding of the pathogenesis of this disease and the biology of the syphilis agent, Treponema pallidum subsp. pallidum has improved over the last two decades, further research is necessary to improve clinical diagnosis and disease management protocols. Read More

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http://dx.doi.org/10.1186/s12879-020-05141-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309211PMC

Large transmission cluster of acute hepatitis C identified among HIV-positive men who have sex with men in Bangkok, Thailand.

Liver Int 2020 Jun 23. Epub 2020 Jun 23.

Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

A rapidly emerging and highly concentrated HCV outbreak has recently been observed among both acute and chronic HIV-positive MSM in Bangkok, Thailand. NS5B regions of the HCV genome were amplified using nested-PCR and sequenced. Phylogenetic inference was constructed by Maximum Likelihood methods and clusters were identified with support and genetic distance thresholds of 85% and of 4. Read More

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http://dx.doi.org/10.1111/liv.14578DOI Listing

Balanophora polyandra Griff. prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome.

Food Funct 2020 Jun 23. Epub 2020 Jun 23.

College of Medical Science, China Three Gorges University, Yichang, 443002, China. and Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, 443002, China and Tumor Microenvironment and Immunotherapy Key Laboratory of Hubei province, China Three Gorges University, Yichang, 443002, China.

Balanophora polyandra Griff. (B. polyandra) is a folk medicine used as an antipyretic, antidote, haemostatic, dressing and haematic tonic, for the treatment of gonorrhea, syphilis, wounds, and the bleeding of the alimentary tract by the local people in China. Read More

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http://dx.doi.org/10.1039/c9fo02494hDOI Listing

Frequency of Screening and Prevalence of Neurosyphilis in Stroke Population.

Cerebrovasc Dis 2020 Jun 22:1-6. Epub 2020 Jun 22.

Neurology and Stroke Unit Service, Nossa Senhora da Conceição Hospital, Porto Alegre, Brazil.

Background And Aims: Syphilis and stroke are high prevalent diseases in south Brazil and estimates of concomitance and possible role of syphilis in acute stroke are lacking. Our aims are to estimate the prevalence of syphilis and neurosyphilis (NS) in a cohort of tertiary stroke center.

Methods: We reviewed all hospital records of stroke/transitory ischemic attack (TIA) using International Classification of Diseases, 10th revision, at discharge, frequency of syphilis screen, serology positivity, cerebrospinal fluid (CSF) analysis, and prevalence of NS in this stroke population applying CDC criteria. Read More

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http://dx.doi.org/10.1159/000508491DOI Listing

Syphilis in an Italian medieval jewish community: A bioarchaeological and cultural perspective.

Int J Paleopathol 2020 Jun 19;30:85-97. Epub 2020 Jun 19.

Dept. of Biological, Geological and Environmental Sciences, Alma Mater Studiorum-University of Bologna, Bologna, Italy.

Objectives: We aim to discuss the presence of treponemal infections in three individuals belonging to a large (∼400 individuals) Late Medieval cemetery (14th -16th century) that archaeological and documentary sources place within a Jewish context, and to discuss the role of these diseases in a biocultural perspective.

Materials And Methods: An anthropological and paleopathological study was conducted on skeletal remains of three individuals, though macroscopic and tomographic examination.

Results: Cranial lesions in which simultaneous destructive and proliferative processes (caries sicca) are noted. Read More

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http://dx.doi.org/10.1016/j.ijpp.2020.06.001DOI Listing

Syphilis: A Contemporary Clinicopathologic Assessment.

Am J Surg Pathol 2020 Jun 19. Epub 2020 Jun 19.

Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, Evanston, IL.

Syphilis is a sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum that has been of public health concern for centuries. In the United States, it is currently a reportable disease and one which is recently generating increasing case numbers especially in at risk populations of immune deficiency and men who have sex with men. The present series examines biopsies from 13 patients collected over a 12-year period from a general hospital network in north suburban Cook County, Illinois. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001523DOI Listing

Syphilis in the Pleven region, Bulgaria: a retrospective study.

Acta Dermatovenerol Alp Pannonica Adriat 2020 Jun;29(2):63-66

Department of Epidemiology, Medical University of Pleven, Pleven, Bulgaria.

Introduction: Syphilis is a sexually transmitted infection whose significance to public health has not lost its relevance. Changes in the epidemiology of the disease have been observed in the last decade. This study describes syphilis trends in the Pleven region (Bulgaria). Read More

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Blemished noses in the art of three masters: Ghirlandaio, Rembrandt, and Warhol.

Clin Dermatol 2020 May - Jun;38(3):360-364. Epub 2019 Oct 24.

Private Practice, Pembroke Pines, Florida, USA. Electronic address:

Blemished noses are portrayed in the paintings of such noted artists as Ghirlandaio, Rembrandt, and Andy Warhol. Sometimes, the deformity results from a skin disorder such as rhinophyma as in Ghirlandaio's An Old Man and his Grandson or a saddle nose deformity from congenital syphilis as in Rembrandt's Portrait of Gerard de Lairesse. Andy Warhol's Before and After portrays a large nose before and after cosmetic surgery. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.10.023DOI Listing
October 2019

Population Prevalence of sexually transmitted infections in a high HIV burden district in KwaZulu-Natal, South Africa: Implications for HIV epidemic control.

Int J Infect Dis 2020 Jun 17. Epub 2020 Jun 17.

Centers for Disease Control and Prevention (CDC), Atlanta, USA.

Background: Sexually transmitted infections (STIs) and Human immunodeficiency virus (HIV) share a complex bidirectional relationship, however, population prevalence and the association between the presence of STIs and HIV in a high HIV burden district in KwaZulu-Natal, South Africa is not known.

Methods: A total of 9812 participants aged 15-49 years were enrolled in a cross-sectional population-based household survey. Participants completed a structured questionnaire and provided first-pass urine (males) or self-collected vulvo-vaginal swabs (females) for the detection of STIs. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.046DOI Listing

Burden of preconception morbidity in women of reproductive age from an urban setting in North India.

PLoS One 2020 18;15(6):e0234768. Epub 2020 Jun 18.

Centre for Health Research and Development, Society for Applied Studies, New Delhi, India.

Background: There is a growing interest in the life course approach for the prevention, early detection and subsequent management of morbidity in women of reproductive age to ensure optimal health and nutrition when they enter pregnancy. Reliable estimates of such morbidities are lacking. We report the prevalence of health or nutrition-related morbidities, specifically, anemia, undernutrition, overweight and obesity, sexually transmitted infections (STIs) or reproductive tract infections (RTIs), diabetes or prediabetes, hypothyroidism, hypertension, and depressive symptoms, during the preconception period among women aged 18 to 30 years. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234768PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302496PMC
June 2020
3.234 Impact Factor

Performance of Treponema pallidum recombinant proteins in the serological diagnosis of syphilis.

PLoS One 2020 18;15(6):e0234043. Epub 2020 Jun 18.

Gonçalo Moniz Institute, Oswaldo Cruz Foundation (Fiocruz-BA), Salvador, Bahia, Brazil.

Syphilis serodiagnosis is challenging because distinct clinical forms of the infection may influence serological performance and discordant results between tests make clinical decisions difficult. Several recombinant Treponema pallidum-proteins have already been tested for syphilis diagnosis and they are critical to achieve high accuracy in serological testing. Our aim was to assess the varied from performance of T. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234043PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302711PMC

Prevalence of Syphilis in Children Adopted From Russia.

Actas Dermosifiliogr 2020 Jun 15. Epub 2020 Jun 15.

Centro de Pediatría y Adopción Internacional, Zaragoza, España. Electronic address:

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http://dx.doi.org/10.1016/j.ad.2019.01.019DOI Listing

Current Perspectives on the Impact of Pre-Exposure Prophylaxis Stigma Regarding Men Who Have Sex with Men in the United States.

Authors:
Patrick D Herron

HIV AIDS (Auckl) 2020 18;12:187-192. Epub 2020 May 18.

Department of Family and Social Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.

Pre-exposure prophylaxis or PrEP is a Food and Drug Administration approved human immunodeficiency virus (HIV) prevention tool that reduces the risk of infection by greater than 90%. While it does not provide protection against other sexually transmittable infections and blood-borne illnesses such as hepatitis C, syphilis, chlamydia, and gonorrhea, it is a highly effective in reducing the risk of transmission of HIV among men who have sex with men. Despite the success of PrEP, there remain barriers to PrEP uptake rooted in stigmatized perspectives shared by health professionals, patients, and community members. Read More

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http://dx.doi.org/10.2147/HIV.S214380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244237PMC

High lifetime prevalence of syphilis in men who have sex with men and transgender women versus low lifetime prevalence in female sex workers in Lima, Peru.

Sex Transm Dis 2020 Jun 11. Epub 2020 Jun 11.

Division of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, CA, USA.

Background: The syphilis epidemic continues to cause substantial morbidity worldwide and is worsening despite ongoing control efforts. Syphilis remains an important public health problem among three key populations: men who have sex with men (MSM), transgender women, and female sex workers.

Methods: We conducted a retrospective chart review of patients that received rapid point-of-care treponemal antibody tests from January 2019-July 2019 in four STI clinics in Lima, Peru. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001200DOI Listing

Trends of Human Immunodeficiency Virus, Syphilis, and Hepatitis C Infections Among Men Who Have Sex With Men in Chongqing, China: A Serial Cross-sectional Survey From 2011 to 2018.

Sex Transm Dis 2020 07;47(7):491-498

From the Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China.

Background: Human immunodeficiency virus (HIV) prevalence and incidence rates have expeditiously increased among Chongqing men who have sex with men (MSM) over the past decade. This study investigated the trends of HIV, syphilis, and hepatitis C virus (HCV) infections and behavioral attributes of Chongqing MSM.

Methods: Chongqing MSM who were 18 years or older were recruited annually from 2011 to 2018. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294744PMC

Early sex work initiation and its association with condomless sex and sexually transmitted infections among female sex workers in Iran.

Int J STD AIDS 2020 Jun;31(7):671-679

Department of Epidemiology, Key Populations Program, Center for Public Health and Human Rights, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Early sex work initiation among female sex workers (FSWs) increases their vulnerabilities to high-risk sexual practices and sexually transmitted infections (STIs). We examined the association of early sex work with condomless sex indicators, HIV, and other STIs, including human papillomavirus, chlamydia, trichomoniasis, syphilis, and gonorrhea, among FSWs in Iran. We recruited 1347 FSWs from 13 cities in 2015, with 1296 participants (94. Read More

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http://dx.doi.org/10.1177/0956462420913431DOI Listing

Is the Second Treponemal Test Necessary in the Reverse Algorithm for the Diagnosis of Syphilis?

Clin Lab 2020 Jun;66(6)

Background: This study was performed to investigate the necessity of the second treponemal test and to evaluate the diagnostic performance of the first treponemal test in the reverse algorithm of syphilis diagnosis.

Methods: Abbott Architect Syphilis TP assay, a chemiluminescence immunoassay (CIA), was used as the first step treponemal test. Treponema pallidum haemagglutination assay (TPHA) test results of reactive samples from the first test were recorded. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.191001DOI Listing