35,946 results match your criteria Syphilis


Antibiotic treatment for newborns with congenital syphilis.

Cochrane Database Syst Rev 2019 Feb 15;2:CD012071. Epub 2019 Feb 15.

C/o Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, The University of Liverpool, First Floor, Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, UK, L8 7SS.

Background: Congenital syphilis continues to be a substantial public health problem in many parts of the world. Since the first use of penicillin for the treatment of syphilis in 1943, which was a notable early success, it has remained the preferred and standard treatment including for congenital syphilis. However, the treatment of congenital syphilis is largely based on clinical experience and there is extremely limited evidence on the optimal dose or duration of administration of penicillin or the use of other antibiotics. Read More

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http://dx.doi.org/10.1002/14651858.CD012071.pub2DOI Listing
February 2019

Papillomatous Erythematous Plaques of the Scrotum.

Dermatol Pract Concept 2019 Jan 31;9(1):73-74. Epub 2019 Jan 31.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.5826/dpc.0901a18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368073PMC
January 2019

Associations between impulsivity, risk behavior and HIV, HBV, HCV and syphilis seroprevalence among female prisoners in Indonesia: A cross-sectional study.

PLoS One 2019 15;14(2):e0207970. Epub 2019 Feb 15.

Department of Psychiatry, Division of Research, Radboud University Medical Center, Nijmegen, The Netherlands.

HIV, hepatitis B and C, and syphilis share common transmission routes of which primarily unsafe sexual contact and injecting drug use are important. Impulsivity is a major factor contributing to this transmission risk behavior; however comprehensive studies within female, prison, and Asian populations are scarce. This cross-sectional study aims to delineate the contributions of different aspects of impulsivity to risk behavior, among female inmates living in a prison in Jakarta (N = 214). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207970PLOS
February 2019

Multimodal Imaging of Atypical Acute Syphilitic Posterior Placoid Chorioretinitis Mimicking a White Dot Syndrome.

Ophthalmic Surg Lasers Imaging Retina 2019 Feb;50(2):e52-e55

As rates of infectious syphilis continue to rise in the U.S., it is important to be familiar with known manifestations of ocular syphilis as well as report presentations not previously described in the literature. Read More

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http://dx.doi.org/10.3928/23258160-20190129-20DOI Listing
February 2019

Values of diagnostic tests for the various species of spirochetes.

Med Mal Infect 2019 Feb 11. Epub 2019 Feb 11.

IRD, AP-HM, MEPHI, IHU-Méditerranée Infection, Aix Marseille Université, 13005 Marseille, France.

Bacteria of the Borrelia burgdorferi sensu lato complex, responsible for Lyme disease, are members of the spirochetes phylum. Diagnostic difficulties of Lyme disease are partly due to the characteristics of spirochetes as their culture is tedious or even impossible for some of them. We performed a literature review to assess the value of the various diagnostic tests of spirochetes infections of medical interest such as Lyme borreliosis, relapsing fever borreliae, syphilis, and leptospirosis. Read More

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http://dx.doi.org/10.1016/j.medmal.2019.01.009DOI Listing
February 2019

Acid diterpenes from Copaiba oleoresin (Copaifera langsdorffii): Chemical and plasma stability and intestinal permeability using Caco-2 cells.

J Ethnopharmacol 2019 Feb 11;235:183-189. Epub 2019 Feb 11.

São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP ZIP 14801-902, Brazil. Electronic address:

Ethnopharmacological Relevance: Copaiba oleoresin has been used in folk medicine in the treatment of bronchitis, syphilis, skin diseases and ulcers due to its anti-inflammatory and antiseptic activities, but there is no information about major compounds oral absorption to support the traditional use.

Aim Of Study: Considering the potential of copalic (CA) and kaurenoic acid (KA) - major biological activity (in vitro) diterpenes found in the oleoresin, this study aimed to evaluate the intestinal permeability of CA and KA using Caco-2 cells model as predictive test for oral drug absorption.

Materials And Methods: Chemical stability at pH 1. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.017DOI Listing
February 2019

Increased Methamphetamine, Injection Drug, and Heroin Use Among Women and Heterosexual Men with Primary and Secondary Syphilis - United States, 2013-2017.

MMWR Morb Mortal Wkly Rep 2019 Feb 15;68(6):144-148. Epub 2019 Feb 15.

Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC.

During 2013-2017, the national annual rate of reported primary and secondary (P&S) syphilis cases in the United States increased 72.7%, from 5.5 to 9. Read More

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http://dx.doi.org/10.15585/mmwr.mm6806a4DOI Listing
February 2019
1 Read

An evaluation of sexually transmitted infection and odds of preterm or early term birth using propensity score matching.

Sex Transm Dis 2019 Feb 11. Epub 2019 Feb 11.

California Preterm Birth Initiative, University of California San Francisco, San Francisco, California, USA.

Background: Few studies have examined the relationship between sexually transmitted infections (STIs) and preterm birth (<37 weeks gestation) by subtype (<32 weeks, 32 - 36 weeks, spontaneous, provider-initiated). Here, we evaluate the odds of preterm (by subtype) and early term (37 and 38 weeks gestation) birth in women with an STI compared to a propensity score matched reference population.

Methods: The sample was selected from California births in 2007-2012. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000985DOI Listing
February 2019
1 Read

Localisation of Outer Membrane Proteins in Treponema denticola by Quantitative Proteome Analyses of Outer Membrane Vesicles and Cellular Fractions.

J Proteome Res 2019 Feb 14. Epub 2019 Feb 14.

The identification and localisation of outer membrane proteins (Omps) and lipoproteins in pathogenic treponemes such as T. denticola (periodontitis) and T. pallidum (syphilis) has been challenging. Read More

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http://dx.doi.org/10.1021/acs.jproteome.8b00860DOI Listing
February 2019

Yield of screening blood work and MRI of the brain and orbits in the work-up of unilateral chronic optic neuropathy.

Eye (Lond) 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.

Background/objectives: No guidelines exist for the investigation of treatable causes of chronic optic neuropathy, including sarcoidosis, lupus, and syphilis. The purpose of this study was to determine the diagnostic yield of screening blood work (ACE (Angiotensin Converting Enzyme) for sarcoidosis, Antinuclear Antibodies (ANA) for lupus, CMIA (chemiluminescence microparticle enzyme immunoassay) for syphilis) and contrast-enhanced MRI brain and orbits in atypical unilateral chronic optic neuropathy.

Subjects/methods: Retrospective review from February 2012 to June 2018 at a neuro-ophthalmology practice. Read More

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http://dx.doi.org/10.1038/s41433-018-0326-6DOI Listing
February 2019

Syphilis with Charcot arthropathy: a case report.

Dermatol Ther 2019 Feb 13:e12862. Epub 2019 Feb 13.

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Syphilis is a chronic systemic infectious disease involving multiple organs. Involvement of skeletal system by syphilis including osteochondritis, osteoarthritis, periostitis and osteitis. Charcot arthropathy is an unusual concomitant disease of syphilis, and the incidence had decreased significantly these decades. Read More

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http://dx.doi.org/10.1111/dth.12862DOI Listing
February 2019
1 Read

Vegetating lesions in secondary syphilis.

Authors:
P Del Giudice

Clin Exp Dermatol 2019 Feb 12. Epub 2019 Feb 12.

Infectiology-Dermatology Unit, Centre Hospitalier Intercommunal de Fréjus Saint Raphaël, 83600, Fréjus, France.

I read with great interest the article by Thakrar et al. about oral ulcers as a presentation of secondary syphilis. However, I do not share this clinical description. Read More

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http://dx.doi.org/10.1111/ced.13949DOI Listing
February 2019

What is the Evidence for the Sexual Transmission of Syphilis from Asymptomatic Persons?

Sex Transm Dis 2019 Feb 9. Epub 2019 Feb 9.

Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1097/OLQ.0000000000000987DOI Listing
February 2019

Increasing syphilis detection among patients assigned male at birth screened at a Boston community health center specializing in sexual and gender minority health, 2005-2015.

Sex Transm Dis 2019 Feb 9. Epub 2019 Feb 9.

The Fenway Institute, Fenway Health, Boston, MA.

For patients assigned male at birth seen at a Boston clinic over a decade, we found disproportionate syphilis cases in young patients, Black and Hispanic/Latinx patients, gay/bisexual patients, cisgender men, and those with new or chronic HIV infection; syphilitic reinfections have significantly increased.

Abstract Background: United States syphilis rates have increased to levels last seen in the 1990s. We examined syphilis epidemiology of patients attending a Boston community health center specializing in sexual and gender minority health. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000986DOI Listing
February 2019
1 Read

Persistent high-risk behavior and escalating HIV, syphilis and hepatitis B incidences among men who have sex with men living in Bangui, Central African Republic.

Pan Afr Med J 2018 23;29:132. Epub 2018 Feb 23.

Laboratoire de Virologie, Hôpital Européen Georges Pompidou and Université Paris Descartes, Bio Sorbonne Paris Cité, Paris, France.

Introduction: HIV in sub-Saharan Africa remains a great concern in men who have sex with men (MSM). Intervention on MSM is a key strategy to control the burden of HIV among this population. Herein we assessed the effect of 2 years of HIV testing and counseling on risk-tacking and HIV and STI incidences among MSM living in Bangui in the Central African Republic. Read More

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http://www.panafrican-med-journal.com/content/article/29/132
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http://dx.doi.org/10.11604/pamj.2018.29.132.12794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358028PMC
February 2018
2 Reads

Dermatologic care for lesbian, gay, bisexual, and transgender persons: Epidemiology, screening, and disease prevention.

J Am Acad Dermatol 2019 Mar;80(3):591-602

Department of Dermatology, Kaiser Permanente, San Francisco, California.

Lesbian, gay, bisexual, and transgender (LGBT) persons face important health issues relevant to dermatologists. Men who have sex with men (MSM) are at higher risk of certain infectious diseases, including HIV, syphilis and other sexually transmitted diseases (STDs), methicillin-resistant Staphylococcus aureus infections, and invasive meningococcal disease, and might be at higher risk of non-infectious conditions, including skin cancer. Recommendations for preventive health care, including screening for HIV and other STDs, sexual health-related vaccinations, and HIV pre-exposure prophylaxis, differ for MSM compared with non-MSM. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.02.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375301PMC
March 2019
1 Read

HIV testing and HIV knowledge among men who have sex with men in Natal, Northeast Brazil.

Braz J Infect Dis 2019 Feb 8. Epub 2019 Feb 8.

Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.

Background: Men who have sex with men (MSM) account for the highest prevalence of HIV in Brazil. HIV testing allows to implement preventive measures, reduces transmission, morbidity, and mortality.

Methods: We conducted a cross-sectional study to evaluate HIV testing during lifetime, factors associated with the decision to test, knowledge about HIV transmission, and use of condoms between MSM from the city of Natal, northeast Brazil. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.01.003DOI Listing
February 2019

Review of the Captain America Graphic Novel 'TRUTH: Red, White and Black' Focusing on Parallels with the Infamous USPHS Syphilis Study at Tuskegee.

J Natl Med Assoc 2019 Feb 7. Epub 2019 Feb 7.

National Center for Bioethics in Research and Health Care, Tuskegee University, United States.

This review presents the first detailed presentation of the parallelism between the Tuskegee Syphilis Study and the Captain America graphic novel 'TRUTH: Red, White and Black', published as a graphic novel by Marvel Comics in 2004 as a paperback, and then in 2009 as a hardcover. First written, published and distributed monthly in 2003 as pre-sequel seven comic book series to tell the story of the origins of the WWII superhero Captain America. In 2003, Marvel Comics chose to tell a 'very dark story' to explain the origins of Captain America, a half century after the initial introduction of Captain America as a WWII action hero in 1940. Read More

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http://dx.doi.org/10.1016/j.jnma.2019.01.004DOI Listing
February 2019
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Syphilis.

Enferm Infecc Microbiol Clin 2019 Feb 6. Epub 2019 Feb 6.

Servicio de Microbiología, Hospital Universitario de Cabueñes, Gijón, Asturias, España; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, España; Grupo de Estudio de ITS de la SEIMC (GEITS), Madrid, España.

Syphilis is an infectious disease caused by the spirochaete Treponema pallidum subsp. pallidum which is transmitted by sexual contact or vertical transmission during pregnancy. The incidence of syphilis has increased in the last years, mainly among men who have sex with men. Read More

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http://dx.doi.org/10.1016/j.eimc.2018.12.009DOI Listing
February 2019
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Evaluation of the Abbott ARCHITECT™ cytomegalovirus IgM/IgG, rubella IgM/IgG, and syphilis treponemal antibodies enzyme immunoassays in a mother and child health center population.

Diagn Microbiol Infect Dis 2019 Jan 17. Epub 2019 Jan 17.

Université de Montréal, 2900 Boulevard Édouard-Montpetit, Montréal, Québec, Canada, H3T 1J4; Centre Hospitalier Universitaire Sainte-Justine, 3175 Chemin de la Côte Sainte-Catherine, Montreal, Quebec, Canada, H3T 1C4.

This study evaluated the concordance of Architect™ chemiluminescent microparticle immunoassays with Captia™ ELISA for cytomegalovirus (CMV) IgM and IgG, with Enzygnost™ and Captia™ ELISA for rubella IgM and IgG and with Trep-Sure™ ELISA for syphilis treponemal antibodies in a mixed pediatric and obstetrical population. Total agreement between assays and Kappa statistic value were 82.5% (95% CI: 75. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07328893193002
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http://dx.doi.org/10.1016/j.diagmicrobio.2018.12.017DOI Listing
January 2019
2 Reads

The Women and Children's Infectious Diseases Center: An integrated approach to congenital infectious diseases.

Clin Invest Med 2019 Jan 30;41(4):E211-E212. Epub 2019 Jan 30.

Department of Pediatrics, Faculty of Medicine, Université de Montréal, Montréal, QC.

Congenital infectious diseases, transmitted during the course of pregnancy, are estimated to affect nearly one in every hundred births worldwide. These infections may be associated with fetal and infant adverse health outcomes, due to congenital malformations caused by in utero transmission of the infectious organism itself (as is the case with cytomegalovirus, toxoplasmosis, syphilis and Zika virus), or due to chronic infection in the infant (as is the case with human immunodeficiency virus [HIV] and hepatitis B and C). In addition, children who are exposed, yet uninfected, may still suffer from the consequences of exposure to infectious pathogens or to the drugs given to treat pregnant women and prevent in utero transmission (as may be the case with HIV infection). Read More

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http://dx.doi.org/10.25011/cim.v41i4.32223DOI Listing
January 2019
1 Read

Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery.

J Exp Clin Cancer Res 2019 Feb 8;38(1):62. Epub 2019 Feb 8.

Department of Oncology, Zhengzhou Central Hospital, Zhengzhou, Henan, China.

Objective: To investigate the lung cancer-promoting mechanism of mesenchymal stem cell-secreted extracellular vesicles (MSC-EV).

Methods: EV were isolated from culture media of human bone marrow-derived MSCs that were pre-challenged with or without hypoxia (referred to as H-EV and N-EV, respectively). After treatment with N-EV or H-EV, A549 and H23 cell proliferation, apoptosis, trans-well invasion and epithelial-to-mesenchymal transition (EMT) were examined. Read More

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http://dx.doi.org/10.1186/s13046-019-1027-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367822PMC
February 2019
1 Read

Decline in the seroprevalence of syphilis markers among first-time blood donors in Libreville (Gabon) between 2004 and 2016.

BMC Public Health 2019 Feb 8;19(1):167. Epub 2019 Feb 8.

University of Cambridge, Cambridge, UK.

Background: Very few studies have been conducted on the seroprevalence of syphilis in Gabon. According to the World Health Organization, the average seroprevalence of syphilis has declined from 5.5 to 1. Read More

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http://dx.doi.org/10.1186/s12889-019-6489-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368695PMC
February 2019
2 Reads
2.264 Impact Factor

Syphilis co-infection is not associated with an increased risk of virologic failure among HIV-positive men who have sex with men on antiretroviral therapy.

J Acquir Immune Defic Syndr 2019 Jan 25. Epub 2019 Jan 25.

St. Michael's Hospital.

Background: Incidence of syphilis continues to rise among HIV-positive men who have sex with men (MSM) in Ontario. Our objective was to determine the effect of acute syphilis on virologic failure (VF) among virally suppressed HIV-positive MSM taking antiretroviral therapy (ART) and determine if the relationship is confounded by drug use.

Setting: The OHTN Cohort Study is a voluntary cohort of people receiving HIV care in Ontario. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001962DOI Listing
January 2019

Perspectives on male partner notification and treatment for syphilis among antenatal women and their partners in Kampala and Wakiso districts, Uganda.

BMC Infect Dis 2019 Feb 6;19(1):124. Epub 2019 Feb 6.

Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda.

Background: Syphilis screening can be successfully integrated into antenatal clinics, and potentially avert significant morbidity and mortality to unborn infants. A minority of male partners report for testing and treatment, increasing the likelihood of reinfection. We conducted a qualitative study to understand factors influencing male partners to seek treatment after syphilis notification by their pregnant partners. Read More

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http://dx.doi.org/10.1186/s12879-019-3695-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366113PMC
February 2019

Female sex workers in Kigali, Rwanda: a key population at risk of HIV, sexually transmitted infections, and unplanned pregnancy.

Int J STD AIDS 2019 Feb 6:956462418817050. Epub 2019 Feb 6.

1 Projet San Francisco, Rwanda Zambia HIV Research Group, Kigali, Rwanda.

Female sex workers (FSWs) were recruited from known hotspots in Kigali, Rwanda, and offered free, anonymous human immunodeficiency virus (HIV) counseling and testing, diagnosis and treatment of sexually transmitted infections (STIs) and long-acting reversible contraception (LARC). From September 2012 to March 2015, 1168 FSWs sought services, including 587 (50%) who were HIV-positive. More than 90% had previously tested for HIV, and 26% who reported previously testing negative had seroconverted. Read More

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http://dx.doi.org/10.1177/0956462418817050DOI Listing
February 2019
1 Read

Why Are Mothers Still Passing Syphilis to Their Babies?

Authors:
Rita Rubin

JAMA 2019 Feb 6. Epub 2019 Feb 6.

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http://dx.doi.org/10.1001/jama.2018.20843DOI Listing
February 2019
35.289 Impact Factor

[The Isenheim altarpiece: religion, art and medicine].

Authors:
Felipe C Cabello

Rev Med Chil 2018 Sep;146(9):1050-1058

Department of Microbiology and Immunology, New York Medical College, USA.

Northern Europe at the beginning of the 16th Century was in turmoil as a result of religious and political dissention, epidemics of plague, syphilis, ergotism, and famine, and the threat of the Ottoman Empire. In Alsace, a fulcrum between Germany, France, Switzerland and the Netherlands, Grünewald painted his celebrated and complex altarpiece at Isenheim in a convent chapel of the Antonine religious order that kept a hospital for the care of patients suffering from ergotism, plague, syphilis and other illnesses. The ten paintings of this altarpiece convey a series of religious, medical and political meanings, with the scenes of the Crucifixion and the Resurrection being thought to play an integral part of the curative process. Read More

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http://dx.doi.org/10.4067/s0034-98872018000901050DOI Listing
September 2018
2 Reads

Post-bacterial infection chronic fatigue syndrome is not a latent infection.

Med Mal Infect 2019 Feb 2. Epub 2019 Feb 2.

Aix Marseille University, IRD, MEPHI, IHU, méditerranée infection, AP-HM, 13385 Marseille cedex 05, France.

Post-infectious chronic fatigue syndrome is a public health problem. Etiologies and physiopathological mechanisms are unknown. Some viruses are known to be involved in post-infectious chronic fatigue syndrome, but the role of bacterial infection is still questioned, especially in cases of post-treatment Lyme disease syndrome where subjective symptoms are regularly attributed to the presence of the dormant bacterium without scientific evidence. Read More

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http://dx.doi.org/10.1016/j.medmal.2019.01.006DOI Listing
February 2019
1 Read

Bacterial sexually transmitted infections in France: recent trends and patients' characteristics in 2016.

Euro Surveill 2019 Jan;24(5)

Santé publique France (the French national public health agency), Saint-Maurice, France.

Diagnoses of bacterial sexually transmitted infections (STI) have been increasing in France since their resurgence in the late 1990s. This article presents recent epidemiological trends until 2016 and the patients' characteristics. STI surveillance relies on sentinel networks: a clinician-based network RésIST (clinical, biological and behavioural data for early syphilis and gonorrhoea), the lymphogranuloma venereum (LGV) network (clinical, biological and behavioural data for rectal LGV, and the laboratory networks Rénachla and Rénago (demographic and biological data for chlamydial infections and gonorrhoea, respectively). Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.5.1800038DOI Listing
January 2019
3 Reads

[Ocular lesions in HIV-infected patients of the ophthalmic hospitals].

Vestn Oftalmol 2018 ;134(6):25-32

Perm State Medical University named after E.A. Wagner, 26 Petropavlovskaya St., Perm, Russian Federation, 614000; Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, 91 Pervomaiskaya St., Yekaterinburg, Russian Federation, 620041.

Purpose: To analyze ophthalmic pathologies in HIV-infected patients of the ophthalmic hospitals of Perm city.

Material And Methods: Medical records of 75 HIV patients registered in Perm Regional Centre for Prevention and Control of AIDS and Infectious Diseases who had received treatment in ophthalmic in-patient clinics of Perm in 2005-2015 years were analyzed retrospectively. Patient examination included traditional ophthalmological methods, as well as immunological (determination of CD4 cells and viral load), serological (detection of antibodies to herpes simplex virus, cytomegalovirus, chlamydia, toxoplasma), general clinical methods, and consultations by allied specialists. Read More

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http://dx.doi.org/10.17116/oftalma201813406125DOI Listing
January 2018
5 Reads

Genetic stability of the typing loci used in the multilocus sequence typing and enhanced CDC typing of syphilis treponemes.

Sex Transm Dis 2019 Jan 30. Epub 2019 Jan 30.

Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

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http://dx.doi.org/10.1097/OLQ.0000000000000981DOI Listing
January 2019

Predictors of serological cure after treatment in patients with early syphilis: A retrospective observational study in Thailand.

Indian J Dermatol Venereol Leprol 2019 Mar-Apr;85(2):235

Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Some patients with early syphilis who receive appropriate treatment do not reach a serological cure and have a persistent titer which does not meet the criteria for treatment failure (serofast state).

Aims: This retrospective study aimed to determine the prevalence of serological cure and the serofast state as well as the factors associated with serological cure after treatment of patients with early syphilis.

Methods: A serological cure was defined as occurring when there was a ≥4-fold decrease in nontreponemal titer, whereas patients with a ≥4-fold increase were considered as having either a treatment failure or reinfection. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_810_17DOI Listing
February 2019
1 Read

Syphilitic Rash in a non-HIV Female Patient.

Authors:
Naoki Yanagisawa

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Bureau of International Health Cooperation, National Center for Global Health and Medicine, Japan.

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http://dx.doi.org/10.2169/internalmedicine.2404-18DOI Listing
February 2019

Treponema pallidum induces the activation of endothelial cells via macrophage-derived exosomes.

Arch Dermatol Res 2019 Mar 2;311(2):121-130. Epub 2019 Feb 2.

Department of Dermatology, Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, 214002, China.

Recent studies have shown that exosomes play a role in pathogenesis and in the treatment of inflammatory diseases and tumours. We explored the effects of Treponema pallidum-induced macrophage-derived exosomes on vascular endothelial cells to determine whether they are involved in the pathogenesis of syphilis. A syphilis infection model was established using rabbits to harvest T. Read More

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http://link.springer.com/10.1007/s00403-018-01888-4
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http://dx.doi.org/10.1007/s00403-018-01888-4DOI Listing
March 2019
7 Reads

TPPA titer as a new adaptation for early diagnosis of congenital syphilis: a retrospective analysis of observation over three years in Yunnan, China.

Eur J Med Res 2019 Feb 2;24(1). Epub 2019 Feb 2.

Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.

Background: Early diagnosis of congenital syphilis (CS) is difficult. This study aimed to determine the serological response discipline of syphilis passive antibody (SPA) in infants born to mothers with syphilis and provide the basis for the early diagnosis of CS.

Methods: Thirty-three infants born to mothers with syphilis and six infants with CS were recruited. Read More

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http://dx.doi.org/10.1186/s40001-019-0367-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359842PMC
February 2019

Point-of-care testing (POCT) for HIV/STI targeting MSM in regional Australia at community 'beat' locations.

BMC Health Serv Res 2019 Feb 2;19(1):93. Epub 2019 Feb 2.

School of Commerce, Institute for Resilient Regions, University of Southern Queensland, Main St, Toowoomba, QLD, 4350, Australia.

Background: Innovative health promotion strategies are needed to improve access to HIV testing among regional people in Australia, particularly for men who have sex with men (MSM). This project aimed to establish proof of concept for point-of-care-testing (POCT) via a mobile van clinic at community 'beat' locations. Surveys evaluated client satisfaction, characteristics and testing preferences among 'early adopters'. Read More

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http://dx.doi.org/10.1186/s12913-019-3899-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359847PMC
February 2019
2 Reads

Increasing Syphilis in Rhode Island: Return of an Old Foe.

R I Med J (2013) 2019 Feb 1;102(1):50-54. Epub 2019 Feb 1.

Associate Professor, Department of Medicine, Brown University, Providence, RI.

The number of people diagnosed with syphilis has increased significantly in the United States over the last decade. In Rhode Island, the number of new diagnoses has increased more than four-fold since 2008. Syphilis disproportionately impacts gay, bisexual, and other men who have sex with men (MSM), with those from African American and Hispanic/Latino communities most affected. Read More

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February 2019
4 Reads

Trends in HIV prevalence and risk behaviours among men who have sex with men from 2013 to 2017 in Nanjing, China: a consecutive cross-sectional survey.

BMJ Open 2019 Jan 30;9(1):e021955. Epub 2019 Jan 30.

Department of Epidemiology, School of Public Health, University of California, Los Angeles, California, USA.

Objective: To examine the trends of HIV prevalence, risk behaviours and HIV testing among men who have sex with men (MSM) in Nanjing.

Design: Five consecutive cross-sectional surveys.

Setting: Nanjing, China. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-021955DOI Listing
January 2019
2 Reads
2.063 Impact Factor

Field evaluation of a dual rapid Human Immunodeficiency Virus and treponemal syphilis rapid test in community-based clinics in Los Angeles and New York.

Diagn Microbiol Infect Dis 2018 Oct 11. Epub 2018 Oct 11.

David Geffen School of Medicine at UCLA, 10920 Wilshire Blvd, Los Angeles, CA, 90024, USA.

Introduction: Dual human immunodeficiency virus/syphilis rapid diagnostic devices can play an important role in prevention efforts. The field performance of the INSTI Multiplex HIV-1/HIV-2/Syphilis Antibody Test (Multiplex) was evaluated.

Methods: Fingerstick whole blood was tested using the rapid test. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.10.002DOI Listing
October 2018
2 Reads

Screening for Sexually Transmitted Diseases.

Prim Care 2019 Mar 24;46(1):157-173. Epub 2018 Dec 24.

Residency in General Preventive Medicine and Public Health, Florida Department of Health, Palm Beach County, 800 Clematis, West Palm Beach, FL 33401, USA.

This article discusses sexually transmitted infections (STI) screening and focuses on reportable STIs. This includes gonorrhea, chlamydia, syphilis, and human immunodeficiency virus. Hepatitis B and C, trichomonas, and herpes are covered as well. Read More

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http://dx.doi.org/10.1016/j.pop.2018.10.013DOI Listing
March 2019
4 Reads

Seroprevalence of syphilis and its risk factors among pregnant women attending antenatal care at Felege Hiwot Referral Hospital, Bahir Dar, northwest Ethiopia: a cross-sectional study.

BMC Res Notes 2019 Jan 31;12(1):69. Epub 2019 Jan 31.

Biology Department, College of Science, Bahir Dar University, P.O. Box-79, Bahir Dar, Ethiopia.

Objective: The objective of this study was to investigate the seroprevalence and associated risk factors of syphilis among pregnant women attending antenatal care at Felege Hiwot Referral Hospital, northwest Ethiopia.

Result: Of the total 384 screened women for syphilis, 10 (2.6%) were found to be seropositive for Treponema pallidum. Read More

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http://dx.doi.org/10.1186/s13104-019-4106-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357495PMC
January 2019

Syphilis among newly diagnosed therapy-naive HIV patients in Belém, Pará, Amazon Region of Brazil.

AIDS Res Hum Retroviruses 2019 Feb 1. Epub 2019 Feb 1.

Universidade Federal do Pará, Laboratório de Virologia, Belem, Para, Brazil.

The incidence of syphilis has increased in people living with HIV/AIDS in recent years. Thus, this study described the prevalence and risk factors associated with syphilis in newly diagnosed individuals with HIV infection, antiretroviral-naive, in the city of Belém, Pará, northern Brazil. A cross-sectional study was conducted from May 2016 to June 2017. Read More

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http://dx.doi.org/10.1089/AID.2019.0007DOI Listing
February 2019
1 Read

[Sexually Transmitted Infections - What's New, What's Different?]

Dtsch Med Wochenschr 2019 Feb 31;144(3):165-170. Epub 2019 Jan 31.

Abteilung Infektiologie, Klinik für Innere Medizin II, Universitätsklinikum Freiburg.

The incidence of sexually transmitted infections like syphilis or gonorrhea is still rising, particularly in the high-risk population of men having sex with men (MSM). Neisseria gonorrhoeae is capable to develop resistance to all antibiotics previously or currently used for treatment. Dual antimicrobial therapy with ceftriaxone and azithromycin is considered the current empirical first-line therapy. Read More

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http://dx.doi.org/10.1055/a-0655-6657DOI Listing
February 2019
4 Reads

Evaluation of HIV risk and outcomes in a nationally representative sample of incarcerated women in Azerbaijan, Kyrgyzstan, and Ukraine.

AIDS Care 2019 Jan 31:1-5. Epub 2019 Jan 31.

a Department of Internal Medicine, AIDS Program , Yale University , New Haven , CT , USA.

Eastern European and Central Asian (EECA) is the only region globally where HIV incidence continues to rise. HIV is concentrated among high risk groups like prisoners. HIV prevalence is higher among women than men in both prisons and communities. Read More

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https://www.tandfonline.com/doi/full/10.1080/09540121.2019.1
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http://dx.doi.org/10.1080/09540121.2019.1573969DOI Listing
January 2019
4 Reads

Three cases of late syphilitic hepatitis.

Ter Arkh 2018 Apr;90(4):96-99

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow Healthcare Department, Moscow, Russia.

The article presents literature data for the last 10 years on specific liver damage. There are three own clinical cases of syphilitic hepatitis, one of them - with a lethal outcome. Attention is drawn to the importance of early diagnosis of syphilitic hepatitis. Read More

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http://dx.doi.org/10.26442/terarkh201890496-99DOI Listing
April 2018
2 Reads

Hepatitis in patients with syphilis: an overlooked association.

BMJ Case Rep 2019 Jan 28;12(1). Epub 2019 Jan 28.

Clínica Médica C, Hospital de Clínicas, Montevideo, Uruguay.

We present the case of a patient who sought treatment for fever and a maculopapular rash involving the trunk, limbs, palms and soles. The patient also presented with hepatomegaly and elevated levels of liver enzymes (with a higher increase of alkaline phosphatase). With the proposal of early syphilitic hepatitis, during the stage of secondary syphilis, a venereal disease research laboratory and haemagglutination tests were requested, which confirmed the diagnosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-226918DOI Listing
January 2019