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Sex Transm Dis 2019 Apr 17. Epub 2019 Apr 17.

University of Washington School of Medicine, Seattle, WA, USA.

Background: Syphilis prevalence in sub-Saharan Africa appears to be stable or declining but is still the highest globally. Ongoing sentinel surveillance in high-risk populations is necessary to inform management and detect changes in syphilis trends. We assessed serological syphilis markers among persons with sexually transmitted infections in Zimbabwe. Read More

Cureus 2019 Feb 5;11(2):e4015. Epub 2019 Feb 5.

Ophthalmology, Universiti Sains Malaysia, Kota Bharu, MYS.

Introduction Ocular syphilis is a sight-threatening condition. It can occur at any stage of syphilis infection, which present either with acute inflammation during the primary, secondary, and early latent stages or with chronic inflammation during tertiary infection, affecting virtually every ocular structure. This study was to report on the clinical presentation of ocular syphilis that presented to eye clinic Hospital Universiti Sains Malaysia. Read More

Pan Afr Med J 2018 3;31:81. Epub 2018 Oct 3.

Division of Hematology and Oncology, Mayo Clinic, 13400 E, Shea Blvd Scottsdale, 85259 AZ, USA.

Introduction: Blood-borne pathogens such as human immunodeficiency virus (HIV), hepatitis B and C (HBV and HCV) viruses and remain a major public health problem in sub-Saharan Africa. The purpose of this study was to assess the frequency and clinical implications of HIV, HBV, HCV and markers in blood donors in a rural area of Southeast Gabon (Koula-Moutou) from 2012 to 2017.

Methods: Hepatitis B surface antigen (HBsAg), anti-HIV, anti-HCV and anti- antibodies were screened using rapid diagnostic tests (RDTs). Read More

Actas Dermosifiliogr 2019 Apr 17. Epub 2019 Apr 17.

Unidad de Gestión Clínica de Dermatología, Servicio de Dermatología, Hospital Universitario Virgen Macarena, Sevilla, España. Electronic address:

Int J STD AIDS 2019 Apr 4;30(5):486-495. Epub 2019 Feb 4.

1 Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

In this study, we assessed if the superimposition of incident sexually transmitted infections (STIs) on HIV phylogenetic analyses could reveal possible sexual behaviour misclassifications in our HIV-infected population. HIV-1 sequences collected between 1997 and 2014 from 1169 individuals attending a HIV clinic in Antwerp, Belgium were analysed to infer a partial HIV transmission network. Individual demographic, clinical and laboratory data collected during routine HIV follow-up were used to compare clustered and non-clustered individuals using logistic regression analyses. Read More

Int J STD AIDS 2019 Apr 10;30(5):509-511. Epub 2019 Jan 10.

1 Servicio de Enfermedades Infecciosas y Tropicales. Hospital Nacional Dos de Mayo, Lima, Peru.

The presentation of syphilis as a manifestation of immune reconstitution inflammatory syndrome in patients with human immunodeficiency virus (HIV) infection is rare and can be associated with the varied clinical expression of unusual syphilitic manifestations. We report a case of immune reconstitution syndrome with dermatologic, ophthalmologic and neurologic compromise of secondary syphilis in a patient with HIV infection. Read More

Int J STD AIDS 2019 Apr 10;30(5):440-446. Epub 2019 Jan 10.

1 Institute for Global Health, UCL, London, UK.

We evaluated associations between history of syphilis infection and both cognitive function and depressive symptoms in people living with HIV (PLHIV) and comparable HIV-negative controls. Syphilis serological tests, cognitive function and depression were assessed in PLHIV and controls participating in the Pharmacokinetic and Clinical Observations in People Over Fifty study. Cognitive test scores were converted to demographically adjusted T-scores (mean = 50, SD = 10) and then averaged to obtain a global T-score. Read More

Klin Monbl Augenheilkd 2019 Apr 18;236(4):516-522. Epub 2019 Apr 18.

Augenklinik, UniversitätsSpital Zürich, Universität Zürich, Schweiz.

Purpose: The spectrum of intraocular and systemic findings in patients with ocular syphilis is described. Persistent visual dysfunction and structural abnormality, in spite of targeted antibiotic therapy, were identified and analysed.

Methods: Patients with ocular syphilis who were treated at University Hospital Zurich (USZ) between 2010 and 2018 were included in this study. Read More

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of General Internal Medicine, Akashi Medical Center, Japan.

We herein report a patient with syphilitic cervicitis and cervical cancer presenting as oropharyngeal syphilis. A 31-year-old Japanese woman with a history of unprotected vaginal and oral sex visited our hospital with right submandibular adenomas and erythema in the extremities. The fornix uteri was red, with a nodule noted. Read More

Sex Transm Infect 2019 May;95(3):236

Sexual Health and HIV, Mortimer Market Centre, London, UK.

PLoS One 2019 17;14(4):e0214229. Epub 2019 Apr 17.

Nigerian Centre for Disease Control, Abuja, Nigeria.

Background: In September 2017, Nigeria experienced a large outbreak of human monkeypox (HMPX). In this study, we report the outbreak experience and response in the Niger Delta University Teaching Hospital (NDUTH), Bayelsa state, where the index case and majority of suspected cases were reported.

Methods: In a cross-sectional study between September 25th and 31st December 2017, we reviewed the clinical and laboratory characteristics of all suspected and confirmed cases of HMPX seen at the NDUTH and appraised the plans, activities and challenges of the hospital in response to the outbreak based on documented observations of the hospital's infection control committee (IPC). Read More

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180475. Epub 2019 Apr 11.

Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.

J Med Microbiol 2019 Apr 17. Epub 2019 Apr 17.

1 Aix-Marseille Univ, CNRS, EFS, ADES, Marseille, France.

Purpose: Syphilis, caused by Treponema pallidum subspecies pallidum, is considered as an old disease affecting humans; traces of such infections, including congenital syphilis, are potentially identifiable in archaeological samples. The aim of this research was to perform macroscopic and molecular investigations of T. pallidum on six infant remains, buried between 1837 and 1867, from the cemetery of 'Les Crottes' in Marseille city (southeastern France). Read More

Indian J Psychiatry 2019 Mar-Apr;61(2):213-216

Department of Neurology, N.R.S. Medical College, Kolkata, West Bengal, India.

Syphilis is a great masquerader of several diseases. About 4%-10% of patients with untreated syphilis may develop neurosyphilis (NS). Psychiatric manifestations may rarely be the presenting feature of NS. Read More

Am Fam Physician 2019 Apr;99(8):Online

J Am Acad Dermatol 2019 Apr 12. Epub 2019 Apr 12.

Department of Dermatology, Kaiser Permanente, San Francisco, CA.

Syphilis is caused by infection with the spirochetal bacterium T. pallidum subsp. pallidum. Read More

J Am Acad Dermatol 2019 Apr 12. Epub 2019 Apr 12.

Department of Dermatology, Kaiser Permanente, San Francisco, CA.

Methods: for laboratory diagnosis of syphilis include direct detection of T. pallidum subsp. pallidum and serologic testing. Read More

Zhonghua Yan Ke Za Zhi 2019 Apr;55(4):267-272

Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the ocular manifestations of human immunodeficiency virus (HIV) and syphilis coinfection. A retrospective analysis of the ocular manifestations was carried out in 27 patients (54 eyes) diagnosed as syphilis and HIV coinfection by the Department of Infectious Medicine in Peking Union Medical College Hospital during the years of 2006-2017. The research included 26 males and 1 female, aging from 24 to 76 years old, with a mean age of 40. Read More

Zhonghua Yan Ke Za Zhi 2019 Apr;55(4):241-245

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Key Laboratory of intraocular Tumor Diagnosis and Treatment, Beijing 100730, China.

In recent years, the incidence of tuberculosis, HIV, syphilis and other infectious diseases has a "rising" trend. The incidence of infectious fundus diseases is also increasing, and missed diagnosis and misdiagnosis are becoming more common. How to diagnose infectious fundus diseases accurately, avoid missed diagnosis and misdiagnosis, carry out standardized treatment in time, carry out research on infectious fundus diseases related to systemic infectious diseases, and save the visual function of patients are the problems we are facing. Read More

Sex Transm Infect 2019 Apr 13. Epub 2019 Apr 13.

Department of Psychiatry, Tzu Chi General Hospital, and School of Medicine, Tzu Chi University, Hualien, Taiwan

Background: Several features of borderline personality disorder (BPD) are likely to be associated with sexual health problems, such as unstable attachment, unstable sexual identity and sexual impulsivity. Since the issue of sex is not openly discussed in Taiwanese society, sexual health needs, including screening and prevention of sexually transmitted infections (STI), are often neglected in this population.

Objective: The study aims to determine whether BPD is associated with an increased risk of subsequent STI in Taiwan. Read More

PLoS One 2019 12;14(4):e0208963. Epub 2019 Apr 12.

National AIDS Control Committee, Yaoundé, Cameroon.

Background: Human Immunodeficiency Virus infection (HIV) remains a public health concern in Cameroon that requires regular surveillance for informed policy-making to guide programmatic interventions. Using data from the 2016 HIV national sentinel survey in Cameroon, we ascertained HIV prevalence and factors associated with risk of infection among pregnant women.

Methods: A cross-sectional study was conducted throughout 2016 in the 10 regions of Cameroon, targeting 7000 first antenatal care (ANC-1) attendees (4000 from urban and 3000 from rural areas) in 60 sentinel health facilities. Read More

Clin Infect Dis 2019 Apr 12. Epub 2019 Apr 12.

Division of STD Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta GA.

Background: Interventions to prevent HIV in women include screening, partner notification, promoting condoms, and pre-exposure prophylaxis (PrEP). Identifying a woman's risk of acquiring HIV can help guide intervention recommendations.

Methods: We used data from Louisiana's STI and HIV registries to study 13- to 59-year-old women following their first diagnosis of syphilis, (or if none) gonorrhea, or (if none) chlamydia during 2000-2015. Read More

PLoS One 2019 11;14(4):e0214755. Epub 2019 Apr 11.

Bahir Dar District Blood Bank, Bahir Dar, Ethiopia.

Background: Blood transfusion is an effective treatment for saving millions of lives even though transfusion- transmissible infections are the major problem. Therefore, the aim of this study was to assess the sero-prevalence and trend of transfusion-transmissible infections among blood donors.

Methods: A retrospective study was conducted form July 2014 to June 2018 at Bahir Dar district blood bank. Read More

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):339-340

Division of Infectious Diseases, Northport Veterans Affairs Medical Center, Northport, NY 11768, USA.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):106-110

Department of Oral and Maxillofacial Pathology, Navodaya Dental College and Hospital, Raichur, Karnataka, India.

Developmental defects of enamel may range from slight abnormalities of the tooth's color, shape and size to a complete absence of the enamel. Permanent first molar may show large variations in their morphological features and forms. Such changes may be in the form of anomalous cusps or variations in the occlusal surface showing globular shaped additional cusps and also increased in number of roots. Read More

Transfusion 2019 Apr 9. Epub 2019 Apr 9.

Vitalant Research Institute, San Francisco, California.

Background: Predonation donor deferral is used to select donors with presumed lower risk for transfused transmitted infections. The contribution to blood safety from this practice has not been reported previously for Brazil.

Study Design And Methods: At four large Brazilian blood centers from September 2010 to March 2011, donors who were deferred due to responses on eligibility questions were invited to provide a blood sample to test for HIV, hepatitis C virus, hepatitis B virus, human T-lymphotropic virus, syphilis, and Trypanosoma cruzi and complete an audio computer-assisted structured interview on risk behaviors. Read More

JAMA 2019 04;321(14):1380-1390

Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.

Importance: Emerging evidence suggests that risk of bacterial sexually transmitted infections (STIs) increases among gay and bisexual men following initiation of HIV preexposure prophylaxis (PrEP).

Objective: To describe STI incidence and behavioral risk factors among a cohort of predominantly gay and bisexual men who use PrEP, and to explore changes in STI incidence following PrEP commencement.

Design, Setting, And Participants: The Pre-exposure Prophylaxis Expanded (PrEPX) Study, a multisite, open-label intervention study, was nested within the Australian Collaboration for Coordinated Enhanced Sentinel Surveillance (ACCESS) clinic network. Read More

Int J STD AIDS 2019 Apr 8:956462419828138. Epub 2019 Apr 8.

6 Office of Research, Pacific University, Forest Grove, OR, USA.

This study examined the comparative health risk behaviors of women who (a) traded sex for money, (b) traded sex for drugs, (c) traded sex for both drugs and money, or (d) did not trade sex. Self-report data were collected from 2369 women who received services through HIV and sexually transmitted infection (STI) testing programs and a subset were tested for HIV, hepatitis B, hepatitis C, and syphilis. Results revealed those women who traded sex only for money used condoms, were tested for HIV, and received the HIV test results more often than the other women. Read More

Salud Publica Mex 2019 Mar-Apr;61(2):116-124

Departamento de Cuidado Integral, Centro Nacional para la Prevención y el Control del VIH y el Sida, Secretaría de Salud. Mexico City, Mexico.

Objective: To identify correlates of HIV/STI prevalence among 13 cities with varying sizes of female sex worker (FSW) populations and municipal characteristics in Mexico.

Materials And Methods: FSWs underwent interviews and testing for HIV, syphilis, gonorrhea and chlamydia. Logistic regression explored variations in HIV/STI prevalence. Read More

Braz J Otorhinolaryngol 2019 Feb 23. Epub 2019 Feb 23.

Universidade Federal de Minas Gerais (UFMG), Faculdade de Odontologia, Department of Oral Surgery and Oral Pathology, Belo Horizonte, MG, Brazil. Electronic address:

Introduction: A resurgence of syphilis in Brazil has been reported in recent years.

Objective: With this in mind, the present study sought to investigate the frequency, demographics, and clinical characteristics of patients with acquired syphilis with oral involvement who received medical care at an Oral Medicine Reference Center in a Brazilian Public Hospital.

Methods: A retrospective study, spanning a period of 12 years, was performed to identify changing trends in syphilis over time. Read More

Clin Exp Dermatol 2019 Apr 3. Epub 2019 Apr 3.

Department of Oral Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.

We thank Dr del Giudice for his interest in our recent article in Clinical and Experimental Dermatology. Our review encompassed the topic of oral ulceration as a manifestation of secondary syphilis and provided by way of example the case histories of two patients. While we agree that the lesions shown in Fig. Read More

Emerg Med Clin North Am 2019 May;37(2):165-192

Prisma Health, University of South Carolina School of Medicine Greenville, 701 Grove Road, Greenville, SC 29605, USA. Electronic address:

Sexually transmitted diseases (STDs) continue to be underrecognized leading to devastating health and economic consequences. Emergency clinicians play an important role in diagnosing and managing STDs and in improving health care outcomes for both the patient and their partners. In addition, antibiotic resistance and emerging infections continue to challenge providers in clinical practice. Read More

BMC Res Notes 2019 Apr 2;12(1):195. Epub 2019 Apr 2.

Division of Global Pediatrics, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

Objective: Deficiency in G6PD is the most common enzymopathy worldwide. It is frequently found in individuals of African descent in whom it can lead to hemolytic crises triggered by the use of certain antimalarial medications and infection. The prevalence of G6PD deficiency and its contribution to morbidity in West Africa is under-studied. Read More

J Clin Lab Anal 2019 Apr 2:e22890. Epub 2019 Apr 2.

Institute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, Collaborative Innovation Center for New Molecular Drug Research, University of South China, Hengyang, China.

Syphilis, a re-emerging public health problem worldwide caused by Treponema pallidum subsp pallidum (T. pallidum), usually induces systemic and chronic inflammation in hosts who do not receive timely therapy after exposing to high-risk factors such as leprous sexual contact. Before the treatment, rapid and accurate detection of syphilis is essential. Read More

J Clin Med Res 2019 Apr 18;11(4):301-304. Epub 2019 Mar 18.

Department of Internal Medicine, Centre Hospitalier de l'Universite de Montreal (CHUM), 1051 rue Sanguinet, H2X 3E4, Montreal, QC, Canada.

A human immunodeficiency virus (HIV)-positive man presented with a recent history of weight loss and B symptoms. Positron emission tomography (PET) scan revealed multiple hypercaptation foci, including diffuse osteomedullary lesions and a dominant liver nodule. Syphilis screening was positive, with a rapid plasma reagin (RPR) titer of 1:1,024. Read More

J Orthop 2019 May-Jun;16(3):260-264. Epub 2019 Mar 12.

Department of Pathology, Johns Hopkins University, Ross Research Building, Room 524A, 720 Rutland Avenue, Baltimore, MD, 21205, United States.

Nerve growth factor (NGF) is the primary neurotrophin in the skeleton and a central mediator of skeletal pain. Recent trials of anti-NGF neutralizing antibodies have resulted in infrequent but well-described incidence of rapidly progressive osteoarthrosis (RPOA). Neuropathy, whether from syphilis or diabetes, is also associated with severe joint destruction, known as neuroarthropathy or Charcot joint. Read More

Aorta (Stamford) 2018 Oct 1;6(5):118-119. Epub 2019 Apr 1.

Section of Cardiac Surgery, University Hospital, Pisa, Italy.

A 69-year-old man presented with precordial pain and a dilated ascending aorta with the suspicion of an intramural hematoma. At emergency operation, the aorta appeared grossly thickened with diffuse intimal scarring. Retrospectively, the patient tested positive to serologic screening for syphilis with histologic findings also compatible with a syphilitic aortitis. Read More

Ugeskr Laeger 2019 Mar;181(12)

This case report of a 36-year-old man, who had sex with men, illustrates, that early identification and diagnosis of neurosyphilis are crucial. Neurosyphilis, being a rare complication of syphilis, is associated with a high risk of severe neurological symptoms such as cranial nerve dysfunction, acute or chronic altered mental status and auditory abnormalities. Treatment with recommended antibiotic regimens can effectively cure neurosyphilis, though the risk of sequelae remains. Read More

J Pregnancy 2019 25;2019:8435019. Epub 2019 Feb 25.

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot 63110, Thailand.

Objectives: Hepatitis B virus (HBV) was believed to have minimal impact on pregnancy outcomes apart from the risk of perinatal transmission. In more recent years, there have been reports of adverse associations, most consistently preterm birth (PTB), but this is in the context of high rates of caesarean section. The aim of this study was to explore the association of HBV on pregnancy outcomes in marginalized, low-income populations on the Myanmar-Thailand border. Read More

Sex Transm Infect 2019 Mar 29. Epub 2019 Mar 29.

Department of Dermatology, Zhejiang University School of Medicine, Second Affiliated Hospital, Hangzhou, China

Objective: Changes in microRNAs (miRNAs) in the cerebrospinal fluid (CSF) are associated with different neurological diseases. Since alternations of miRNAs in neurosyphilis are insufficiently investigated, we analysed miRNAs in the CSF of patients suffering from neurosyphilis.

Methods: Exosomes were isolated from serum and CSF. Read More

J Sex Med 2019 Mar 26. Epub 2019 Mar 26.

Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Research and Informatics Services Center, University of Alabama at Birmingham, Birmingham, AL, USA.

Introduction: Erectile dysfunction (ED) is a common diagnosis in up to 50% of men with HIV and prescription of erectile dysfunction medication (EDM) has been variably associated with increased risk behaviors and acquisition of sexually transmitted infections (STIs).

Aim: We measured the association of EDM prescription with bacterial STI testing, STI infection and sexual behavior among men engaged in HIV care.

Methods: A retrospective cohort study was conducted among HIV-infected men in care at an urban HIV clinic in Birmingham, Alabama between 2008 and 2016. Read More

BMC Infect Dis 2019 Mar 29;19(1):292. Epub 2019 Mar 29.

Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, China.

Background: Syphilis is responsible for a substantial burden of preventable adverse outcomes in pregnancy. The purpose of this study was to compare the frequency of adverse pregnancy outcomes among syphilis-seropositive women who received different treatment regimens at different times in Guangzhou, China.

Methods: Pregnant women with syphilis infection who received prenatal and delivery services in Guangzhou between January 2014 and December 2016 were included. Read More

BMC Infect Dis 2019 Mar 29;19(1):294. Epub 2019 Mar 29.

Faculty of Medicine, University of Toronto, 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada.

Background: African, Caribbean, and Black (Black) men account for 16.5% of new HIV diagnoses among men in Ontario. There is substantial evidence that sexually transmitted infections (STIs) are associated with increased likelihood of HIV infection; however, little is known regarding the prevalence of HIV/STI co-infections among Black men in Toronto. Read More

Am J Ophthalmol Case Rep 2019 Jun 8;14:70-73. Epub 2019 Mar 8.

Department of Ophthalmology, Hospital Universitario Austral, Argentina.

Purpose: To report a case of acute syphilitic posterior placoid chorioretinopathy (ASPPC) that demonstrated partial resolution with immunosuppressive therapy secondary to a misdiagnosis as Behçet's disease followed by a relapse which was successfully treated with the appropriate treatment.

Observations: A 34-year-old female patient presented to our service with complaints of decreased vision in the left eye (OS). She initially developed similar symptoms seven months prior to presentation and was diagnosed as Behçet's disease based on the clinical picture of papillitis, vasculitis and placoid chorioretinitis in the posterior pole of OS. Read More

Sex Transm Infect 2019 Mar 28. Epub 2019 Mar 28.

Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Objective: Syphilis is an STI that potentially affects any organ. Syphilitic hepatitis and neurosyphilis have been reported in both HIV-uninfected and HIV-infected individuals. The aim of this study was to investigate syphilitic hepatitis and neurosyphilis among HIV-infected individuals during a 13-year period. Read More

BMC Public Health 2019 Mar 29;19(1):353. Epub 2019 Mar 29.

National Institute for Public Health and the Environment, Epidemiology and Surveillance unit, P.O. Box 1, 3720, BA, Bilthoven, the Netherlands.

Background: In 2014 the World Health Organisation (WHO) established validation criteria for elimination of mother-to-child transmission (EMTCT) of HIV and syphilis. Additionally, the WHO set targets to eliminate hepatitis, including hepatitis B (HBV). We evaluated to what extent the Netherlands has achieved the combined WHO criteria for EMTCT of HIV, syphilis and HBV. Read More

J Dtsch Dermatol Ges 2019 Mar;17(3):287-315

WIR "Walk In Ruhr", competence network HIV/AIDS, Center for Sexual Health and Medicine, Department of Dermatology, Venereology and Allergology, Ruhr University, Bochum, Germany.

Worldwide, the incidence of bacterial sexually transmitted infections (STIs) has shown a significant increase in recent years. In Germany, this circumstance is reflected by a rise in the number of reported syphilis cases. There has also been an uptick in the incidence of non-notifiable STIs such as gonorrhea and infections caused by Chlamydia trachomatis and Mycoplasma genitalium. Read More

J Dtsch Dermatol Ges 2019 Mar;17(3):287-317

WIR "Walk In Ruhr", Kompetenznetz HIV/AIDS, Zentrum für Sexuelle Gesundheit und Medizin, Klinik für Dermatologie, Venerologie und Allergologie, Ruhr-Universität Bochum.

Bakterielle sexuell übertragbare Infektionen (STI) zeigen seit Jahren weltweit eine deutliche Zunahme. In Deutschland wird diese Tatsache durch steigende Meldezahlen für Syphilis bestätigt. Auch für die nicht meldepflichtigen STI Gonorrhoe, Chlamydia-trachomatis- und Mycoplasma-genitalium-Infektionen wird eine zunehmende Inzidenz beobachtet. Read More

Sex Transm Infect 2019 Mar 27. Epub 2019 Mar 27.

Medical Research Council Clinical Trials Unit at University College London, London, UK.

Objectives: Pre-exposure prophylaxis (PrEP) is a highly effective method of HIV prevention for men who have sex with men (MSM). However, uncertainty remains around the optimal eligibility criteria for PrEP, specifically whether there are subgroups at low risk of HIV for whom PrEP might not be warranted.

Methods: PROUD was an open-label waitlist trial design that randomised MSM attending participating sexual health centres in England to receive PrEP immediately (IMM) or after a deferral period of 1 year (DEF). Read More