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    1 OF 681

    Malignant syphilis: ostraceous, ulceronecrotic lesions in a patient with human immunodeficiency virus.
    Dermatol Online J 2017 Jan 15;23(1). Epub 2017 Jan 15.
    Department of Pathology, University of Florida, UF Health Jacksonville.
    We present a 36-year-old HIV-positive man with a sixweek history of spreading, ulcerative, and necroticcutaneous lesions. Laboratory and histopathologicexamination revealed syphilis. This case of malignantsyphilis, also known as lues maligna, is an uncommonvariant of this sexually transmitted infection. Read More

    Prevalence and factors associated with syphilis in a Reference Center.
    Rev Soc Bras Med Trop 2017 Jan-Feb;50(1):27-34
    Departamento de Enfermagem, Universidade Estadual de Londrina, Londrina, PR, Brasil.
    Introduction:: The implementation of the rapid test (RT) for syphilis increases access of vulnerable populations to early diagnosis and treatment, impacting the outcomes of infection. We aimed to assess the prevalence of and factors associated with syphilis in a Center for Testing and Counseling (CTC).

    Methods:: We conducted a cross-sectional study at a Reference Center for sexually transmitted disease (STD) and acquired immune deficiency syndrome in Londrina, Northern Paraná State, Southern Brazil. Read More

    Estimating prevalence trends in adult gonorrhoea and syphilis in low- and middle-income countries with the Spectrum-STI model: results for Zimbabwe and Morocco from 1995 to 2016.
    Sex Transm Infect 2017 Mar 21. Epub 2017 Mar 21.
    Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
    Objective: To develop a tool for estimating national trends in adult prevalence of sexually transmitted infections by low- and middle-income countries, using standardised, routinely collected programme indicator data.

    Methods: The Spectrum-STI model fits time trends in the prevalence of active syphilis through logistic regression on prevalence data from antenatal clinic-based surveys, routine antenatal screening and general population surveys where available, weighting data by their national coverage and representativeness. Gonorrhoea prevalence was fitted as a moving average on population surveys (from the country, neighbouring countries and historic regional estimates), with trends informed additionally by urethral discharge case reports, where these were considered to have reasonably stable completeness. Read More

    [Cutaneous manifestations of sarcoidosis].
    Z Rheumatol 2017 Mar 17. Epub 2017 Mar 17.
    Abteilung für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.
    Skin manifestations of sarcoidosis occur in up to 30% of cases. This review summarizes and illustrates in detail the differences between specific and unspecific skin manifestations of sarcoidosis. Important differential diagnoses, such as tuberculosis, cutaneous lymphoma and syphilis have to be excluded. Read More

    Silent killers: Transfusion Transmissible Infections-TTI, among asymptomatic population of Pakistan.
    J Pak Med Assoc 2017 Mar;67(3):369-374
    Pathology, Sahiwal Medical College, Sahiwal, Pakistan.
    Objective: To analyse transfusion transmissible infections in asymptomatic population.

    Methods: This study was conducted at the Allama Iqbal Medical College and Jinnah Hospital, Lahore, Pakistan, from December 2014 to November 2015, and comprised healthy asymptomatic blood donors.Every sample was screened for the presence of antibodies/antigens of hepatitis C virus, human immunodeficiency virus, treponemapallidum, hepatitis B virus and malaria parasite through rapid immunochromatographic technique. Read More

    HIV/AIDS in the South-East Asia region: progress and challenges.
    J Virus Erad 2016 Nov 28;2(Suppl 4):1-6. Epub 2016 Nov 28.
    World Health Organization South-East Asia Region , New Delhi , India.
    The South-East Asia region, with 11 member states, has an estimated 3.5 million people living with HIV (PLHIV). More than 99% of PLHIV live in five countries where HIV prevalence among the population aged 15-49 remains low but is between 2% and 29% among key populations. Read More

    Correlates of county-level nonviral sexually transmitted infection hot spots in the US: application of hot spot analysis and spatial logistic regression.
    Ann Epidemiol 2017 Feb 21. Epub 2017 Feb 21.
    Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA. Electronic address:
    Purpose: We used a combination of hot spot analysis (HSA) and spatial regression to examine county-level hot spot correlates for the most commonly reported nonviral sexually transmitted infections (STIs) in the 48 contiguous states in the United States (US).

    Methods: We obtained reported county-level total case rates of chlamydia, gonorrhea, and primary and secondary (P&S) syphilis in all counties in the 48 contiguous states from national surveillance data and computed temporally smoothed rates using 2008-2012 data. Covariates were obtained from county-level multiyear (2008-2012) American Community Surveys from the US census. Read More

    Early malignant syphilis.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):148-150
    Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
    Early malignant syphilis is a rare and severe variant of secondary syphilis. It is clinically characterized by lesions, which can suppurate and be accompanied by systemic symptoms such as high fever, asthenia, myalgia, and torpor state. We report a diabetic patient with characteristic features of the disease showing favorable evolution of the lesions after appropriate treatment. Read More

    [Lues - Ocular syphilis].
    Ophthalmologe 2017 Mar 14. Epub 2017 Mar 14.
    Klinik für Augenheilkunde, Medizinische Fakultät, Universitätsklinikum Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.
    Ocular syphilis is not a new issue but due to increasing rates of new cases is now a contemporary issue. The clinical features are unspecific and can be manifested as all forms of ocular inflammation. Unspecific anterior uveitis is the most frequent ocular involvement; however, typical distinctive patterns are superficial white preretinal precipitates within a panuveitis and acute syphilitic posterior placoid chorioretinitis. Read More

    [Sero-epidemiological study of three sexually transmitted infections: Chlamydia Trachomatis, Hepatitis B, Syphilis. A case study conducted at the Nkoldongo District Hospital in Yaoundé].
    Pan Afr Med J 2016 20;25:244. Epub 2016 Dec 20.
    Institut de Recherches Médicales et d'Etudes de Plantes Médicinales, Ministère de la Recherche Scientifique et de l'Innovation, Yaoundé, Cameroun.

    [Neurosyphilis in Psychiatric Settings: Three Case Reports].
    Turk Psikiyatri Derg 2017 ;28(1):61-66
    Syphilis is a generally sexually transmitted and multisystem disease caused by the spirochete Treponema pallidum. All of the organs of the body may be involved during the course of the disease. Neurosyphilis is a clinical form of syphilis with the central nervous system (CNS) involvement. Read More

    Neutropenia induced by high-dose intravenous benzylpenicillin in treating neurosyphilis: Does it really matter?
    PLoS Negl Trop Dis 2017 Mar 13;11(3):e0005456. Epub 2017 Mar 13.
    Sexually Transmitted Disease Institute, Shanghai Skin Disease Hospital, Shanghai, People's Republic of China.
    Background: Prompt therapy with high-dose intravenous benzylpenicillin for a prolonged period is critical for neurosyphilis patients to avoid irreversible sequelae. However, life-threatening neutropenia has been reported as a complication of prolonged therapy with high doses of benzylpenicillin when treating other diseases. This study aimed to investigate the incidence, presentation, management and prognosis of benzylpenicillin-induced neutropenia in treating neurosyphilis based on a large sample of syphilis patients in Shanghai. Read More

    Approach to Human Immunodeficiency Virus/Sexually Transmitted Infection Testing for Men at an Urban Urgent Care Center.
    Sex Transm Dis 2017 Apr;44(4):255-259
    From the *Department of Pediatrics, and †Divisions of Infectious Disease and Child and Adolescent Health, Columbia University Medical Center, New York, NY.
    Background And Objectives: Sexually transmitted infection (STI) rates have increased among men. Urgent care centers are increasingly common sites for medical care. The objectives of this study are to describe practices surrounding STI testing at an urban urgent care center. Read More

    Comparison of In-Person Versus Telephone Interviews for Early Syphilis and Human Immunodeficiency Virus Partner Services in King County, Washington (2010-2014).
    Sex Transm Dis 2017 Apr;44(4):249-254
    From the *Department of Medicine, Division of Infectious Diseases, Wayne State University, Detroit, MI; †Department of Medicine, University of Washington; ‡Public Health-Seattle and King County HIV/STD Program; §Department of Medicine, Division of Allergy and Infectious Diseases, and ¶Departments of Epidemiology and Global Health, University of Washington, Seattle, WA.
    Background: The relative effectiveness of in-person versus telephone interviews for human immunodeficiency virus (HIV)/sexually transmitted disease partner services (PS) is uncertain.

    Methods: We compared outcomes of in-person versus telephone PS interviews for early syphilis (ES) and newly diagnosed HIV in King County, Washington from 2010 to 2014. We used multivariable Poisson regression to evaluate indices (number of partners per original patient [OP]) for partners named, notified, tested, diagnosed, and treated (ES only). Read More

    Suboptimal Prenatal Syphilis Testing Among Commercially Insured Women in the United States, 2013.
    Sex Transm Dis 2017 Apr;44(4):219-221
    From the Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
    United States surveillance data demonstrate that congenital syphilis cases are increasing. We performed an analysis of commercially insured pregnant females using MarketSan to determine syphilis screening rates at different prenatal stages; 85% of pregnant women in this population had a syphilis test performed at least once during the prenatal period. Read More

    Diagnostic Tests for Evaluation of Stillbirth: Stillbirth Collaborative Research Network.
    Obstet Gynecol 2017 Mar 6. Epub 2017 Mar 6.
    University of Utah School of Medicine and Intermountain Health Care, Salt Lake City, Utah; Rollins School of Public Health, Emory University, Atlanta, Georgia; RTI International, Research Triangle Park, North Carolina; the Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; the University of Texas Health Science Center at San Antonio, San Antonio, and the University of Texas Medical Branch at Galveston, Galveston, Texas; Brown University School of Medicine, Providence, Rhode Island; and Columbia University, New York, New York.
    Objective: To estimate the usefulness of each diagnostic test in the work-up for potential causes of stillbirth.

    Methods: A secondary analysis of 512 stillbirths enrolled in the Stillbirth Collaborative Research Network from 2006 to 2008 was performed. The Stillbirth Collaborative Research Network was a multisite, geographically, racially, and ethnically diverse, population-based study of stillbirth in the United States. Read More

    Prevalence and risk factors of HIV and syphilis, and knowledge and risk behaviors related to HIV/AIDS among men who have sex with men in Chongqing, China.
    J Biomed Res 2016 Mar 11;30(2):101-111. Epub 2015 Jun 11.
    National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
    High HIV prevalence and incidence burdens have been reported in men who have sex with men (MSM) in Chongqing, China. We aimed to estimate the prevalence of HIV and other sexually transmitted infections (STIs), to appraise the knowledge and risk behaviors related to HIV/AIDS among MSM, and to analyze the possible causes of deviation between behavior and knowledge to make better strategies. We recruited 617 MSM from February to July in 2008 by using a respondent-driven sampling (RDS) method in Chongqing, China. Read More

    [Circulating levels of Th1- and Th2-chemokines increase in patients with early syphilis].
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2017 Mar;33(3):380-383
    Department of Clinical Laboratory, First Affliated Hospital of Bengbu Medical College, Bengbu 233004, China. *Corresponding author, E-mail:
    Objective To study the changes of plasma T helper type I (Th1)-and Th2-chemokine levels and analyze their roles in immune response and pathogenesis of early syphilis. Methods Heparin-anticoagulated peripheral blood was collected from 56 patients with early syphilis (primary syphilis, PS, n=22; secondary syphilis, SS, n=34) and healthy controls (HC, n=20). The levels of plasma Th1 chemokines including monokine induced by interferon-γ (MIG), interferon-γ inducible protein-10 (IP-10), interferon-inducible T-cell α chemoattractant (I-TAC) and Th2 chemokines including thymus-and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) were examined using ELISA. Read More

    Immune reconstitution inflammatory syndrome presenting as secondary syphilis with polymorphous erythema and knee arthritis.
    J Eur Acad Dermatol Venereol 2017 Mar 8. Epub 2017 Mar 8.
    Infectious Diseases Department, University Hospital Hotel-Dieu, Nantes University, Nantes, France.
    Syphilis and HIV are strongly linked to one another and immune reconstitution inflammatory syndrome (IRIS) after antiretroviral therapy (ART) initiation can complicate matters. A 24-years-old homosexual man was hospitalized for fever, cough and headache. HIV infection had been diagnosed 5 years earlier but he discontinued ART for the last 2 years. Read More

    A non-healing syphilid: Another face of the great imitator.
    IDCases 2017 11;8:14-16. Epub 2017 Feb 11.
    Cadham Provincial Public Health Laboratory, Winnipeg, MB, Canada; Department of Medical Microbiology & Infectious Diseases, Max Rady College of Medicine, Raddy Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Department Immunology, Max Rady College of Medicine, Raddy Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
    The global re-emergence of syphilis is an exigent public health issue requiring both clinicians and public health practitioners to become familiar with the myriad manifestations of this great imitator. This report describes a case of an originally undiagnosed chronic oral syphilitic chancre, subsequently confirmed by both PCR and immunohistochemistry. Read More

    Relationships between neighbourhood characteristics and current STI status among HIV-infected and HIV-uninfected women living in the Southern USA: a cross-sectional multilevel analysis.
    Sex Transm Infect 2017 Mar 7. Epub 2017 Mar 7.
    Department of Behavioral Sciences and Health Education, Rollins School of Public Health at Emory University, Atlanta, Georgia, USA.
    Objectives: Neighbourhood characteristics (eg, high poverty rates) are associated with STIs among HIV-uninfected women in the USA. However, no multilevel analyses investigating the associations between neighbourhood exposures and STIs have explored these relationships among women living with HIV infection. The objectives of this study were to: (1) examine relationships between neighbourhood characteristics and current STI status and (2) investigate whether the magnitudes and directions of these relationships varied by HIV status in a predominantly HIV-infected cohort of women living in the Southern USA. Read More

    Keratoacanthoma Centrifugum Marginatum: Response to Acitretin.
    Skinmed 2017 1;15(1):69-71. Epub 2017 Feb 1.
    Department of Dermatology, La Rabta Hospital Tunis, Tunis, Tunisia.
    A previously healthy 70-year-old woman presented with a 5-month history of an asymptomatic keratotic, papulonodular plaque on her right forearm. The lesion started as a follicular papule followed by progressive peripheral proliferation. No record of trauma, contact with any chemicals, use of immunosuppressive drugs, or history of neoplasm was noted. Read More

    MR imaging of adult acute infectious encephalitis.
    Med Mal Infect 2017 Mar 3. Epub 2017 Mar 3.
    Service de neurologie, CH Saint-Denis, BP 279, 93205, France.
    Background: Imaging is a key tool for the diagnosis of acute encephalitis. Brain CT scan must be urgently performed to rule out a brain lesion with mass effect that would contraindicate lumbar puncture. Brain MRI is less accessible than CT scan, but can provide crucial information with patients presenting with acute encephalitis. Read More

    The introduction of syphilis point of care tests in resource limited settings.
    Expert Rev Mol Diagn 2017 Apr 14;17(4):321-325. Epub 2017 Mar 14.
    a London School of Hygiene & Tropical Medicine , Keppel Street, London , WC1E 7HT.
    Introduction: Syphilis remains an important and preventable cause of stillbirth and neonatal mortality. About 1 million women with active syphilis become pregnant each year. Without treatment, 25% of them will deliver a stillborn baby and 33% a low birth weight baby with an increased chance of dying in the first month of life. Read More

    Implementing and sustaining a mobile medical clinic for prenatal care and sexually transmitted infection prevention in rural Mysore, India.
    BMC Infect Dis 2017 Mar 6;17(1):189. Epub 2017 Mar 6.
    Public Health Research Institute of India, 89/B, Ambika, 2nd Cross, 2nd Main, Yadavagiri, Mysuru, Karnataka, 570020, India.
    Background: In rural India, mobile medical clinics are useful models for delivering health promotion, education, and care. Mobile medical clinics use fewer providers for larger catchment areas compared to traditional clinic models in resource limited settings, which is especially useful in areas with shortages of healthcare providers and a wide geographical distribution of patients.

    Methods: From 2008 to 2011, we built infrastructure to implement a mobile clinic system to educate rural communities about maternal child health, train community health workers in common safe birthing procedures, and provide comprehensive antenatal care, prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV), and testing for specific infections in a large rural catchment area of pregnant women in rural Mysore. Read More

    Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively.
    PLoS Negl Trop Dis 2017 Mar 6;11(3):e0005434. Epub 2017 Mar 6.
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
    Background: Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion from a patient that returned to France from Pakistan. Read More

    Sexually Transmitted Infection Risk among Women Is Not Fully Explained by Partner Numbers.
    South Med J 2017 Mar;110(3):161-167
    From the Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham.
    Objectives: Increased sexual partner numbers may contribute to sexually transmitted infection (STI) risk for some but not all women. This study compared women reporting having four or more partners during the preceding year (multiple partnership group) with those reporting having one partner (single partnership group) with regard to sexually risky behaviors and other modifiable predictors of STI risk. We also compared the prevalence of bacterial vaginosis, trichomoniasis, chlamydia, gonorrhea, syphilis, herpes simplex virus type 2, and human immunodeficiency virus among groups. Read More

    Evaluation of the automated ADVIA centaur® XP syphilis assay for serological testing.
    Diagn Microbiol Infect Dis 2017 Feb 20. Epub 2017 Feb 20.
    Department of Laboratory Medicine, National University Hospital, National University Health System, Singapore.
    We evaluated the performance of the ADVIA Centaur XP Syphilis assay (Siemens Healthcare Diagnostics, Tarrytown, NY, USA) using samples previously tested on the ARCHITECT i4000SR system (Abbott Diagnostics, Lake Forest, IL, USA) and confirmed by the Treponema pallidum particle agglutination assay (TPPA) (SERODIA-TPPA, Fujirebio Diagnostics Inc., Malvern, PA, USA). Clinical patient information was included to aid resolution of discordant samples where available. Read More

    Predictors and incidence of sexually transmitted Hepatitis C virus infection in HIV positive men who have sex with men.
    BMC Infect Dis 2017 Mar 2;17(1):185. Epub 2017 Mar 2.
    Melbourne Sexual Health Centre, Alfred Health, Melbourne Australia and Central Clinical School, Monash University, Melbourne, Australia.
    Background: Sexual transmission of Hepatitis C virus (HCV) in men who have sex with men (MSM) and its interaction with HIV status, sexually transmitted infections and sexual behaviour is poorly understood. We assessed the incidence and predictors of HCV infection in HIV positive MSM.

    Methods: The electronic medical record and laboratory results from HIV positive MSM in care at a large urban public specialist HIV clinic embedded in a sexual health centre in Melbourne Australia were collected. Read More

    Female Patient with Alport Syndrome and Concomitant Membranous Nephropathy: Susceptibility or Association of Two Diseases?
    Nephron 2017 Mar 1. Epub 2017 Mar 1.
    Alport syndrome (AS) is a disorder of collagen IV, a component of glomerular basement membrane (GBM). The association of AS and immunocomplex nephropathies is uncommon. This is a case of a 37-year-old woman with family history of X-linked AS, including 4 affected sons. Read More

    [Analysis of the Detection Results of the Syphilis Specific Antibody in Blood Donors by Chemiluminescence Method and Enzyme Linked Immunosorbent Assay].
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 2017 Feb;25(1):226-230
    Dongying Hospital of Shangdong Province-owned Hospital, Dongying 257091, Shandong Province, China.
    Objective: To investigate the application value of chemiluminescence method (CMIA) detection of Treponema pallidum (TP) specific antibodies in the blood test.

    Methods: Over the same period the de novo enzyme linked immunosorbent assay (ELISA) and Abbott chemical luminescence method were used to detect the specific antibody of syphilis in a total of 66298 samples; TP-ELISA negative and TP-CMIA positive unpaid blood donation blood samples for syphilis specific antibody were detected and confirmed by Western blot.

    Results: Blood samples from 66298 blood donors were detected by TP-ELISA, the positive samples was 250 and the positive rate was 0. Read More

    Late latent mucinous syphilis mimicking connective tissue disease.
    J Cutan Pathol 2017 Feb 28. Epub 2017 Feb 28.
    Dr Culpepper is from University of Arizona, Clinical Instructor; and Dermpath Diagnostics, Director of Pathology.
    As evidenced by the CDC statistics, syphilis is yet again on the rise. It is known as the great mimicker because of its variable symptoms and how frequently it can be confused with other diseases. The different stages of syphilis (primary, secondary, latent, late latent and tertiary) are discussed. Read More

    The Genus Carissa: An Ethnopharmacological, Phytochemical and Pharmacological Review.
    Nat Prod Bioprospect 2017 Feb 27. Epub 2017 Feb 27.
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
    Carissa L. is a genus of the family Apocynaceae, with about 36 species as evergreen shrubs or small trees native to tropical and subtropical regions of Africa, Asia and Oceania. Most of Carissa plants have been employed and utilized in traditional medicine for various ailments, such as headache, chest complains, rheumatism, oedema, gonorrhoea, syphilis, rabies. Read More

    Aneurysm and dissection in a patient with syphilitic aortitis.
    Braz J Infect Dis 2017 Feb 23. Epub 2017 Feb 23.
    Hospital de Clínicas de Porto Alegre (HCPA), Divisão de Medicina Interna, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Medicina Interna, Divisão de Doenças Infeciosas, Porto Alegre, RS, Brazil.
    In the antibiotic era, aortic aneurysm is a rare complication of syphilis, what makes the diagnostic assumption even more difficult. Nonetheless, this condition should be suspected in patients with aortic aneurysm. Reports of aortic dissection complicating syphilitic aortitis have been distinctly rare in the literature, and their cause-effect relationship has not been definitely established. Read More

    Rapid diagnosis of sexually transmitted infections.
    Enferm Infecc Microbiol Clin 2017 Feb 23. Epub 2017 Feb 23.
    Servicio de Microbiología, Hospital Universitario Central de Asturias, Oviedo, España; Departamento de Biología Funcional, Área de Microbiología, Facultad de Medicina, Oviedo, España; Fundación de Investigación Oftalmológica, Instituto Oftalmológico Fernández-Vega, Oviedo, España. Electronic address:
    Sexually transmitted infections (STIs) are responsible for an enormous burden of morbidity and mortality. Worldwide, millions of cases of STIs, such as syphilis, chlamydia, or gonorrhoea occur every year, and there is now an increase in antimicrobial resistance in pathogens, such as gonococcus. Delay in diagnosis is one of the factors that justifies the difficulty in controlling these infections. Read More

    HIV Risk Behaviors and Correlates of Inconsistent Condom Use Among Substance Using Migrants at the Mexico/Guatemala Border.
    AIDS Behav 2017 Feb 25. Epub 2017 Feb 25.
    Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
    This study assessed correlates of inconsistent condom use with casual partners and the prevalence of sexual risk behaviors and STIs in the Mexico/Guatemala border region using a sample of 392 migrants (303 men, 85 women) who reported current substance use or problem drinking. We ran separate univariate logistic regression models for men and women, and multivariate logistic regression models for men only. Prevalence of syphilis was 1. Read More

    Molecular typing of Treponema pallidum isolates from Buenos Aires, Argentina: Frequent Nichols-like isolates and low levels of macrolide resistance.
    PLoS One 2017 24;12(2):e0172905. Epub 2017 Feb 24.
    Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
    A total of 54 clinical samples, including genital lesion swabs, whole blood and cerebrospinal fluid from patients diagnosed with syphilis were collected in 2006 and in 2013 in Buenos Aires, Argentina. Treponemal DNA was detected in 43 of the analyzed samples (79.6%) and further analyzed using Sequencing-based molecular typing (SBMT) and Enhanced CDC-typing (ECDCT). Read More

    Periungual Lesion due to Secondary Syphilis.
    Skin Appendage Disord 2017 Jan 21;2(3-4):116-119. Epub 2016 Sep 21.
    Dermatology Clinic, Hospital do Servidor Público Municipal de São Paulo, São Paulo, Brazil.
    Several countries experience a new epidemic of syphilis, mainly due to the changes in risk behaviors. Dermatologists play an important role in the diagnosis, since cutaneous manifestations are frequent during disease progression. We report a rare case of secondary syphilis with periungual involvement. Read More

    Evaluation of positive and false-positive results in syphilis screening of blood donors in Rio de Janeiro, Brazil.
    Transfus Med 2017 Feb 23. Epub 2017 Feb 23.
    Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, Brazil.
    Objectives: We propose to analyse the positive and false-positive results of treponemal and nontreponemal tests in blood donors from Brazil and to evaluate possible factors associated with the results of treponemal tests.

    Background: Treponemal tests have been used widely for syphilis screening in blood banks. The introduction of these tests in donor screening has caused an impact and a loss of donors who need to be assessed. Read More

    Alkaloid extracts from Combretum zeyheri inhibit the growth of Mycobacterium smegmatis.
    BMC Complement Altern Med 2017 Feb 23;17(1):124. Epub 2017 Feb 23.
    Department of Biochemistry, University of Zimbabwe, P.O. Box MP 167, Mt. Pleasant, Harare, Zimbabwe.
    Background: Current tuberculosis regimens have failed to combat the issue of drug resistance and ethno medicines may represent a possible source of antimycobacterial agents. Combretum species are well known in African traditional medicines and used for various ailments including pneumonia, venereal diseases like syphilis, mental problems, relief of sore throats and colds, fever, and chest coughs associated with tuberculosis. Alkaloids function as either hydrogen-acceptor or hydrogen-donor in hydrogen bonding critical for the interaction between targets thus, potentiating effects of curative agents on diseases. Read More

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