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Histopathology 2022 Jun 27. Epub 2022 Jun 27.

Department of Pathology, University of California San Francisco, USA.

Front Immunol 2022 10;13:910337. Epub 2022 Jun 10.

Department of Ophthalmology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

Purpose: To report the demographic, clinical, and laboratory characteristics of ocular syphilis based on a 6-year case series study from an eye center in East-China.

Methods: A total of 131 cases (191 eyes) of ocular syphilis and the annual number of total syphilis cases from January 2016 to December 2021, were included in this study. Detailed medical records including systemic and ophthalmic medical history, a complete ophthalmic examination, color fundus photography, B-type ultrasound, fundus fluorescein angiography (FFA), spectral domain optical coherence tomography (SD-OCT), laboratory tests of the serum and cerebrospinal fluid (CSF) samples, as well as visual field test and orbital or cranial MRI in cases with suspected optic neuritis or optic atrophy, were collected and analyzed. Read More

Proc (Bayl Univ Med Cent) 2022 27;35(4):548-549. Epub 2022 Apr 27.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.

Since the era of antibiotics, the frequency of secondary syphilis manifestations has declined. During the last decade, there has been a resurgence of syphilis cases. We describe a case of a 28-year-old man with various secondary syphilis symptoms including alopecia with the well-described characteristic "crown of Venus" pattern not commonly seen during this decade, as well as mucosal plaques, pustules, and palmoplantar macular rash. Read More

BMC Infect Dis 2022 Jun 26;22(1):574. Epub 2022 Jun 26.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Background: World Health Organization announced its goal of ending sexually transmitted infection (STI) epidemics by 2030. To provide a reference for tailored prevention strategies, we analyzed trends and differences in STIs by geographical regions and age groups from 1990 to 2019.

Methods: Annual number of new infections and age-standardized incidence rates (ASRs) of syphilis, chlamydia, gonorrhea, trichomoniasis, and genital herpes were recorded from the 2019 Global Burden of Disease study. Read More

EClinicalMedicine 2022 Jul 20;49:101465. Epub 2022 May 20.

School of Public Health, Peking University, Beijing, China.

Background: Hepatitis B virus (HBV) infection is a serious global health problem and China has the largest disease burden. Literatures focusing on economic-related inequalities in HBV infection among pregnant women are scarce. We aimed to quantify the economic-related inequalities and the change over time in HBV infection among pregnant women in mainland China from 2013 to 2020 to inform strategies considering economic-related inequalities. Read More

Cureus 2022 May 19;14(5):e25132. Epub 2022 May 19.

Infectious Diseases, University of Florida College of Medicine, Jacksonville, USA.

Syphilis has been called "the great masquerader." In this case report, we present a case of an HIV-negative patient with left eye redness and decreased vision. Syphilitic anterior uveitis as a complication of neurosyphilis was subsequently diagnosed and the patient showed marked improvement with treatment. Read More

Pharmaceutics 2022 Jun 16;14(6). Epub 2022 Jun 16.

Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.

The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914, that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood-brain barrier (BBB). Owing to restricted transport across the BBB, FDA-approved drugs for the CNS have been generally limited to lipid-soluble small molecules. Drugs that do not cross the BBB can be re-engineered for transport on endogenous BBB carrier-mediated transport and receptor-mediated transport systems, which were identified during the 1970s-1980s. Read More

Pathogens 2022 May 24;11(6). Epub 2022 May 24.

Oral Medicine and Periodontology Department, Faculty of Dentistry, The University of the Western Cape, Cape Town 7530, South Africa.

Syphilis is an infectious disease caused by Syphilis can present with an array of oral manifestations at different stages of disease progression. This article reports on four cases of syphilis with oral manifestations diagnosed by oral health professionals. Case 1: 18-year-old female presented with multiple ulcerations and patches involving the hard palate, uvula, retromolar area, and papillary nodules on the tongue. Read More

J Perinatol 2022 Jun 23. Epub 2022 Jun 23.

Western Center for Agricultural Health and Safety, University of California, Davis, CA, USA.

Objective: To investigate differences in congenital syphilis (CS) infection between California's small-to-medium and large metropolitan counties and the socioeconomic mechanisms behind these differences.

Study Design: County-level data from 2019 and 2020 on CS infection and other socioeconomic covariates were obtained from the California Department of Public Health and the United States Census Bureau. Counties were stratified into small-to-medium or large metropolitan counties by the National Center for Health Statistics Urban-Rural Classification Scheme and analyzed using simple and multiple Poisson regression models. Read More

Microbiol Spectr 2022 Jun 23:e0248221. Epub 2022 Jun 23.

Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.

Syphilis, caused by Treponema pallidum subspecies (TP), is a complex multistage infectious disease. Systematic dissemination occurs within a few hours of transmission. We determined the molecular variation of TP at various body locations and peripheral blood within patients in different stages of syphilis to assess the distribution of TP strains at these locations. Read More

Recent Adv Antiinfect Drug Discov 2022 Jun 22. Epub 2022 Jun 22.

Department of General Surgery, AIIMS Rishikesh.

BACKGROUND Convalescent plasma has been used to provide passive immunotherapy to patients with Covid-19 with a high level of safety. Very few efficacy studies were available, and COVID being a relatively new disease, exact therapeutic role was unclear. This observational study on impact of Covid convalescent plasma (CCP) on clinical outcomes attempts to evaluate the effectiveness of convalescent Covid 19 plasma therapy in treatment of Covid 19 patients at the tertiary care center in the Uttarakhand state of India. Read More

Sex Transm Infect 2022 Jun 22. Epub 2022 Jun 22.

Melbourne Sexual Health Centre, Alfred Health, Carlton, Victoria, Australia.

Objectives: Condylomata lata are a less common but distinctive syphilitic lesion. Variable theories as to their nature and origin exist. The aim of this study was to determine the clinical and laboratory characteristics of condylomata lata by determining (1): the most closely aligned stage of syphilis, based on the rapid plasma reagin (RPR) titre; (2) symptom duration and (3) PCR cycle threshold (C) values, as an indicator of organism load. Read More

Med Clin (Barc) 2022 Jun 17. Epub 2022 Jun 17.

Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Infectious Diseases Research Group, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; Medicine Department, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: The emergence of chemsex has raised several concerns about gay, bisexual, and other men who have sex with men's (GBMSM) health. In this study we aim to analyze illicit drugs and chemsex use, sexual behavior and sexually transmitted infections (STI) in GBMSM who attended to a sexual health clinic and to explore any potential association between drug use and STI.

Methods: We conducted an observational study between January and June 2019 among GBMSM population attending to a STI clinic in Barcelona, Spain. Read More

BMC Infect Dis 2022 Jun 20;22(1):561. Epub 2022 Jun 20.

Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton, UK.

Background: Sexually transmitted infections (STIs) in low- and middle-income countries (LMICs) are predominantly managed by syndromic management. However, most STIs are asymptomatic. These untreated STIs cause individual morbidity, and lead to high STI prevalences. Read More

BMC Pregnancy Childbirth 2022 Jun 20;22(1):501. Epub 2022 Jun 20.

NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, 400020, Shanghai, China.

Background: Reproductive tract infections can cause serious adverse outcomes for pregnant women such as spontaneous abortion and preterm birth. However, it is unclear whether maternal reproductive tract infection before pregnancy would also be related to any adverse pregnancy outcomes. This study aims to investigate the association of maternal preconception reproductive tract infections with subsequent adverse pregnancy outcomes. Read More

Zhonghua Liu Xing Bing Xue Za Zhi 2022 Jun;43(6):892-897

Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518000, China.

To evaluate the effect of social media based behavioral intervention on promoting joint testing of HIV and syphilis in young men who have sex with men (MSM). After the recruitment, the participants who met the inclusion criteria were randomly divided (1∶1) into two groups, i.e. Read More

Front Microbiol 2022 3;13:888525. Epub 2022 May 3.

Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.

The etiological agent of syphilis, ssp. , is a highly invasive "stealth" pathogen that can evade the host immune response and persist within the host for decades. This obligate human pathogen is adept at establishing infection and surviving at sites within the host that have a multitude of competing microbes, sometimes including pathogens. Read More

Front Public Health 2022 2;10:860171. Epub 2022 Jun 2.

Chinese Center for Disease Control and Prevention, Beijing, China.

Background: This study aimed to evaluate HIV incidence, factors associated with HIV incidence and transmitted drug resistance (TDR) among newly infected men who have sex with men (MSM) in Harbin, P.R. China. Read More

J Appl Lab Med 2022 Jun 18. Epub 2022 Jun 18.

Quest Diagnostics, North Region, Marlborough, MA, USA.

Background: In 2019, the CDC updated serology testing guidelines for Lyme disease diagnosis to include alternative modified two-tiered testing that replaces the western blots of standard testing with an additional ELISA. Antibody-capture serological assays have also been used as an aid for Lyme diagnosis. A panel of clinically characterized samples from the CDC was tested to compare modified two-tiered testing to the standard two-tiered algorithm and an antibody capture immunoassay. Read More

Milbank Q 2022 Jun;100(2):327-340

Wellesley College.

J Community Hosp Intern Med Perspect 2022 12;12(2):10-13. Epub 2022 Apr 12.

Trinitas Regional Medical Center, Department of Internal Medicine, 225 Williamson Street Elizabeth, NJ 07202, USA.

Syphilis is a sexually transmitted disease spread by spirochete Treponema Pallidum, it has a varied range of symptoms and is divided into stages primary, secondary and tertiary. Central nervous system (CNS) invasion occurs early in the disease in almost all the patients, and does not follow any particular stage. However, clinical manifestation depends on whether inflammatory response occurs. Read More

Oman Med J 2022 May 31;37(3):e386. Epub 2022 May 31.

Directorate of Research, Shifa Tameer-e-Millat University, Islamabad, Pakistan.

Objectives: This study aimed to determine the prevalence of blood transfusion-transmitted infections (TTIs), among blood donors in Pakistan, specifically HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis, and malaria.

Methods: Data records of all registered blood donors (n = 120 968) during 2008-2019, at a blood transfusion center in a tertiary care hospital were assessed. Frequency of the seropositive donors for HIV, HCV, HBV, syphilis, and malaria was analyzed. Read More

Paediatr Child Health 2022 Jun 21;27(3):183-189. Epub 2022 Mar 21.

Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.

Background: Infectious syphilis has been increasing in incidence in Manitoba since 2012, especially in heterosexual women of childbearing age resulting in an increasing number of infants with in utero exposure and who are at risk for congenital syphilis (CS). We aimed to evaluate the impact of syphilis in pregnancy on infants and to describe our experience with CS.

Methodology: This retrospective 2012 to 2018 cohort study reviewed women with syphilis in pregnancy and short-term infant outcomes. Read More

J Community Hosp Intern Med Perspect 2022 2;12(3):57-60. Epub 2022 May 2.

Cape Fear Valley Medical Center, Fayetteville, NC.

Neurosyphilis is the progression of the untreated sexually transmitted infection caused by . When the initial infection is not adequately treated, progression of primary syphilis can lead to a wide variety of serious health sequelae. While neurosyphilis can appear up to 10-30 years after the initial infection, syphilis can invade the nervous systemat any stage of infection and can imitate symptoms of many other diseases. Read More

Ann Dermatol Venereol 2022 Jun 13. Epub 2022 Jun 13.

Service des maladies infectieuses, dermatologie, CHU La Réunion, 97448 Saint-Pierre Cedex, Reunion; Inserm CIC1410, CHU La Réunion, 97448 Saint-Pierre Cedex, Reunion.

Trials 2022 Jun 16;23(1):495. Epub 2022 Jun 16.

Department of Global Health, University of Washington, Box 359931, 325 Ninth Ave, WA, 98104, Seattle, USA.

Background: Women in Africa face disproportionate risk of human immunodeficiency virus (HIV) acquisition, accounting for more than half of new infections in Africa and similarly face a disproportionate burden of sexually transmitted infections (STIs). Very high STI prevalence is being observed globally, especially among people taking pre-exposure prophylaxis (PrEP) for HIV prevention. Doxycycline post-exposure prophylaxis (dPEP) has been proposed as an STI prevention strategy to reduce chlamydia, syphilis, and possibly gonorrhea, and trials are ongoing among cisgender men who have sex with men (MSM) and transgender women who are taking PrEP in high-income settings. Read More

Ear Nose Throat J 2022 Jun 16:1455613221095605. Epub 2022 Jun 16.

Department of Head and Neck Surgery, 12222University of California Los Angeles, Los Angeles, CA, 90095, USA.

Secondary syphilis rarely affects the head and neck including the oropharynx and cervical lymph nodes. These patients present with throat pain, cystic/necrotic lymphadenopathy, and mucosal swelling. Sometimes this constellation of symptoms can be mistaken for head and neck cancer. Read More

OTO Open 2022 Apr-Jun;6(2):2473974X221100206. Epub 2022 Jun 10.

Department of Otolaryngology-Head and Neck Surgery, Bon Secours Mercy Health, St Elizabeth Boardman Hospital, Boardman, Ohio, USA.

Infect Dis Poverty 2022 Jun 15;11(1):68. Epub 2022 Jun 15.

Capital Institute of Pediatrics, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China.

Background: The number of HIV-positive pregnant women accounted for about 10% of China's total over the past few years in Liangshan Prefecture, Sichuan province in China. Although cost-effectiveness of the PMTCT of HIV have been evaluated in other previous studies, no specific study has been conducted in Liangshan prefecture, nor has the expenses paid individually by HIV-positive pregnant women been included. The purpose of this study was to evaluate both the short-term and long-term cost-effectiveness of PMTCT of HIV in Liangshan Prefecture from the social perspective. Read More

Prev Sci 2022 Jun 15. Epub 2022 Jun 15.

Research On Healthcare Performance RESHAPE, INSERM U1290, Université Claude Bernard Lyon 1, Lyon, France.

Screening is an essential prevention practice for a number of health conditions. However, screening coverage remains generally low. Studies that investigate determinants of screening participation are becoming more common, but oftentimes investigate screening for health conditions in an individualized rather than integrated fashion. Read More