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    [HIV/AIDS infection in children and adolescents: Chilean cohort 1987-2014].
    Rev Chilena Infectol 2016 Oct;33(Suppl 1):11-19
    Hospital San Borja Arriarán, Santiago, Chile.
    The present document describes the Cohort of HIV/AIDS children detected in Chile from 1987 to August 2014 and the effectiveness of the Protocol for Prevention of Vertical Transmission (PPVT) of HIV infection. Of the 375 HIV infected children enrolled since 1987 to August 2014, 245 of them are still in pediatric control. From the analysis of the Cohort is inferred that: a) it has observed an improvement in the detection of the HIV infected child, in number and precocious time; b) the majority of these children continue to be detected by clinic symptoms and signs (mainly unspecific and infectious manifestations); c) the ARVT use has meant a clinic and immunologic improvement with diminution of the infections, principally opportunistic infections, with a better life quality, a prolongation of survival and a diminution of lethality; d) as more survival has been produced, cancer has begun to be detected, a very infrequent complication observed in them before the ARVT use. Read More

    The history of an unknown dermatological wax collection from Cluj-Napoca University "Iuliu Hatieganu", Romania.
    Wien Med Wochenschr 2017 Apr 26. Epub 2017 Apr 26.
    University G. Marconi, Rome, Italy.
    Among the dermatological wax collections across Europe, one of the latest created is the collection from Cluj-Napoca University, Romania. The initiator was Professor Coriolan Tataru and the moulage artist employed was Dr. Richard Hoffmann. Read More

    Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study.
    BMC Infect Dis 2017 Apr 26;17(1):310. Epub 2017 Apr 26.
    Zhongshan Hospital, Medical College of Xiamen University, Xiamen, 361004, China.
    Background: Known predictors of neurosyphilis were mainly drawn from human immunodeficiency virus (HIV)-infected syphilis patients, which may not be applicable to HIV-negative populations as they have different characteristics, particularly those with neurological symptoms. This study aimed to identify novel predictors of HIV-negative symptomatic neurosyphilis (S-NS).

    Methods: From June 2005 to June 2015, 370 HIV-negative syphilis patients with neurological symptoms were recruited, consisting of 191 S-NS patients (including 123 confirmed neurosyphilis and 68 probable neurosyphilis patients) and 179 syphilis/non-neurosyphilis (N-NS) patients. Read More

    Risk of congenital syphilis following treatment of maternal syphilis: results of a congenital syphilis control program in China.
    Clin Infect Dis 2017 Apr 21. Epub 2017 Apr 21.
    Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Dermatology and National Center for STD Control, Nanjing, China (Prof. YP Yin, Prof. XS Chen MD, PhD).
    Background.: Early screening for syphilis among pregnant women and the effective treatment of maternal syphilis is fundamental to prevent congenital syphilis (CS).

    Methods. Read More

    Treatment with penicillin G and hydrocortisone reduces ALS-associated symptoms: a case series of three patients.
    F1000Res 2017 3;6:410. Epub 2017 Apr 3.
    2-BBB Medicines, J.H. Oortweg 19, Leiden, 2333 CH, Netherlands.
    Three male Caucasian patients with ALS were admitted to the hospital due to progressive dysphagia and dysarthria. During two 21-day courses of penicillin G and hydrocortisone, these patients' dysphagia and dysarthria resolved. The patient's other ALS-associated symptoms also improved, including respiratory function, coordination, walking, and muscle strength. Read More

    Acral pebbles: A novel manifestation of partially treated syphilis.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):92-94
    Department of Dermatology, Muzaffarnagar Medical College and Hospital, Muzaffarnagar, Uttar Pradesh, India.
    Atypical manifestations in syphilis are known and pose a diagnostic dilemma. Early suspicion, timely investigations, diagnosis, and treatment, is the key to successful management. We report a patient of secondary syphilis, who presented as genital ulcer and small pebbles like eruptions on the palmar aspect of his fingers. Read More

    Co-infection of syphilis and hepatitis B with carcinoma penis in a human immunodeficiency virus male.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):78-80
    Department of STD, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India.
    Human immunodeficiency virus (HIV) infections have a high probability of co-infections with Syphilis and hepatitis B virus since they share the common routes of transmission. We report a 41-year-old HIV male (on antiretroviral therapy for the past 6 years) admitted for a complaint of penile ulcer for 2 months. Serology for syphilis and hepatitis B were positive. Read More

    Clinico-epidemiological profile of patients attending Suraksha Clinic of tertiary care hospital of North India.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):54-59
    Department of Skin and STD, Government Medical College, Amritsar, Punjab, India.
    Background: Sexually transmitted infections (STIs) are a global health problem. Trends of STIs vary from place to place depending on various epidemiological factors prevailing in that respective geographic area.

    Aims And Objectives: The present study was conducted to find the pattern and prevalence of different STIs out of total STI clinic attendees, to identify any change in the trend of STIs, various epidemiological factors, and behavior of individual diseases. Read More

    Study of prevalence of sexually transmitted infections/human immunodeficiency virus and condom use among male-to-female transgender: A retrospective analysis from a tertiary care hospital in Chennai.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):43-46
    Institute of Venereology, Madras Medical College, Chennai, Tamil Nadu, India.
    Context: A "Transgender" person is one who dresses as, desires to be, has undergone surgery to become or identifies with opposite sex. They have a higher risk of sexually transmitted infection (STI) due to a combination of biological and social reasons. They have risky sexual behaviors but low-risk perception. Read More

    Aspects on the history of transmission and favor of distribution of viruses by iatrogenic action: perhaps an example of a paradigm of the worldwide spread of HIV.
    Med Microbiol Immunol 2017 Apr 22. Epub 2017 Apr 22.
    Max von Pettenkofer Institute, National Reference Centre for Retroviruses, Ludwig-Maximilians-University of München, Pettenkofer Str 9A, 80336, Munich, Germany.
    Transmission of infectious agents might be associated with iatrogenic actions of charitable help in health care. An example is the vaccination against yellow fever in USA that transmitted hepatitis B virus. Another example is injections of praziquantel for treatment and cure of schistosomiasis in Central and Northern Africa, with a focus in Egypt that has spread hepatitis C virus. Read More

    Infection prevention and control and the refugee population: Experiences from the University of Louisville Global Health Center.
    Am J Infect Control 2017 Apr 18. Epub 2017 Apr 18.
    University of Louisville Global Health Program, Division of Infectious Diseases, University of Louisville School of Medicine, Louisville, KY.
    Background: During 2016, approximately 140,000 individuals entered the United States as part of the federal government refugee resettlement program and established themselves in communities in virtually every state. No national database regarding refugee health currently exists; therefore, little is known about existing infectious diseases, conditions, and cultural practices that impact successful acculturation. The objective of this report is to identify what is currently known about refugees and circumstances important to infection prevention and control with respect to their roles as new community members, employees, and consumers of health care. Read More

    A national strategic plan for reducing the burden of sexually transmitted infections in Israel by the year 2025.
    Isr J Health Policy Res 2017 19;6:23. Epub 2017 Apr 19.
    Department of Occupational Health, Ministry of Health, Jerusalem, Israel.
    Background: There is on ongoing debate in the literature regarding the real burden of STIs (sexually transmitted infections) in Western countries and the proper strategies needed to estimate and to prevent them. Our purpose is to present an evidence-based national strategic plan for STI prevention in Israel through assessing the current burden of illness, leading international preventive strategies, and practical policymaking experience.

    Methods: Epidemiologic and health policy data on STIs were analyzed from various sources: a) systematic national surveillance data for the years 2002-2014; b) the international scientific literature (published between 2002-16; keywords: Sexually Transmitted Diseases (STD) (or STI) AND prevention AND intervention AND gonorrhea OR chlamydia OR syphilis; c) internal Ministry of Health (MOH) analyses and reports, and d) expert opinion. Read More

    Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study.
    PLoS One 2017 20;12(4):e0175065. Epub 2017 Apr 20.
    Department of Pediatric Cardiology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil.
    Objective: To report the echocardiographic evaluation of 103 infants with presumed congenital Zika syndrome.

    Methods: An observational retrospective study was performed at Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil. Read More

    High Frequency of Illegal Drug Use Influences Condom Use Among Female Transgender Sex Workers in Argentina: Impact on HIV and Syphilis Infections.
    AIDS Behav 2017 Apr 19. Epub 2017 Apr 19.
    CONICET-Universidad de Buenos Aires, Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Paraguay 2155, Piso 11, C1121ABG, Buenos Aires, Argentina.
    The high prevalence of HIV and syphilis found among female transgender sex workers (FTSWs) in Argentina calls for the study of factors leading to negative health consequences. Given the particular characteristics observed in this population (high marginalization, school dropout, and low adherence to healthcare services), we explored the association of several socio-demographic characteristics with syphilis and HIV infections, and the determinants of condom use. This study revealed that FTSWs from Argentina were exposed to several risk factors decreasing thus their ability to negotiate condom use and leading to increased risk for transmission of HIV and other sexually transmitted infections (STIs). Read More

    Increased syphilis testing of men who have sex with men: greater detection of asymptomatic early syphilis and relative reduction in secondary syphilis.
    Clin Infect Dis 2017 Apr 13. Epub 2017 Apr 13.
    Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.
    Background: Syphilis rates have increased markedly among men who have sex with men (MSM) in many countries. This study examined trends in syphilis testing and detection of early syphilis among MSM in Australia.

    Methods: Serial cross-sectional analyses on syphilis testing and diagnoses among MSM attending a national sentinel network of 46 sexual health clinics in Australia between 2007 and 2014. Read More

    Ophthalmic Manifestations of Congenital Zika Syndrome in Colombia and Venezuela.
    JAMA Ophthalmol 2017 Apr 13. Epub 2017 Apr 13.
    Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland8Johns Hopkins Zika Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Importance: The ocular manifestations and sequelae of Zika virus infection are not well known. Recently, the World Health Organization changed the declaration of Zika as a public health emergency and designated the viral outbreak and related microcephaly clusters as a long-term program of work. This change indicates the urgent need to evaluate and document ophthalmic manifestations in patients for timely management of this disease. Read More

    Amoxicillin and Ceftriaxone as Treatment Alternatives to Penicillin for Maternal Syphilis.
    Emerg Infect Dis 2017 May;23(5):827-829
    There is no proven alternative to penicillin for treatment of maternal syphilis. We report 2 case-patients with maternal syphilis who were successfully treated without penicillin. We used amoxicillin and probenecid for the first case-patient and amoxicillin, probenecid, and ceftriaxone for the second case-patient. Read More

    A Case of Early Neurosyphilis.
    J La State Med Soc 2017 Mar-Apr;169(2):47-48. Epub 2017 Apr 15.
    Department of Internal Medicine, LSU Health in Baton Rouge, LA.
    Introduction: Neurosyphilis is an infection of the central nervous system by Treponema pallidum, which can occur after the initial syphilis infection. Although commonly associated with late stage disease, patients with early neurosyphilis may present with acute syphilitic meningitis, meningovascular syphilis, or uveitis.

    Case: A 28 year old man with a past medical history of HIV (CD4 364);, and recent diagnosis of uveitis presented to the Emergency Department with a positive RPR result. Read More

    [Pachymeningitis].
    Rev Med Interne 2017 Apr 13. Epub 2017 Apr 13.
    Service de médecine interne, hôpital Saint-Antoine, AP-HP, DHUi2B, université Paris 6, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
    Pachymeningitis is a fibrosing and inflammatory process, which involves the dura mater. Some pachymeningitis are cranial and induce headaches and cranial nerve palsies. Others are spinal and responsible for nerve roots or spinal cord compression. Read More

    Epidemic characteristics of main infectious diseases in Yantai city between 2010 and 2012 and prevention strategy research.
    Pak J Pharm Sci 2016 Nov;29(6(Special)):2191-2198
    Fushan District People's Hospital, Yantai, Shandong Province, China.
    To investigate the epidemic characteristics and prevention strategies of main infectious diseases. From 2010 to 2012, 23 notifiable diseases were reported in Yantai with average reported cases of 17,376. The morbidity was the highest in 2012 and the lowest in 2011. Read More

    Epidemiological features of and changes in incidence of infectious diseases in China in the first decade after the SARS outbreak: an observational trend study.
    Lancet Infect Dis 2017 Apr 12. Epub 2017 Apr 12.
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. Electronic address:
    Background: The model of infectious disease prevention and control changed significantly in China after the outbreak in 2003 of severe acute respiratory syndrome (SARS), but trends and epidemiological features of infectious diseases are rarely studied. In this study, we aimed to assess specific incidence and mortality trends of 45 notifiable infectious diseases from 2004 to 2013 in China and to investigate the overall effectiveness of current prevention and control strategies.

    Methods: Incidence and mortality data for 45 notifiable infectious diseases were extracted from a WChinese public health science data centre from 2004 to 2013, which covers 31 provinces in mainland China. Read More

    Molecular subtyping of Treponema pallidum and associated factors of serofast status in early syphilis patients: Identified novel genotype and cytokine marker.
    PLoS One 2017 14;12(4):e0175477. Epub 2017 Apr 14.
    Department of Dermatology, Wuxi Second Hospital, Nanjing Medical University, Wuxi, China.
    Serofast, a persistent nontreponemal serological response observed in early syphilis patients after conventional treatment, remains a concern of clinicians and syphilis patients. No consensus has been established, however, that defines an effective treatment strategy and clarifies the pathogenesis. In this study, 517 patients with early syphilis were enrolled and treated. Read More

    Syphilis Masquerading As Mass Lesions: The Utility of Modern-Day Imaging and Molecular Sequencing in Clinical Diagnosis.
    Sex Transm Dis 2017 May;44(5):303-305
    From the *Department of Infectious Diseases, Institute of Infectious Diseases and Epidemiology, and †Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore.
    Syphilis has been known to present in a myriad of symptoms throughout the ages, and until this day, the diagnosis remains elusive to the modern physician. We present 2 unusual cases of syphilis that posed diagnostic challenges even in the current era of new and advancing diagnostic tests. Read More

    Mobile Phone and Internet Use Mostly for Sex-Seeking and Associations With Sexually Transmitted Infections and Sample Characteristics Among Black/African American and Hispanic/Latino Men Who Have Sex With Men in 3 US Cities.
    Sex Transm Dis 2017 May;44(5):284-289
    From the *Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA; †Brown University, Providence, RI; and ‡Health Resources in Action, Boston, MA.
    Background: Men who have sex with men (MSM) have a relatively high prevalence of sexually transmitted infections (STIs). This study examines the association of self-reported STIs and use of mobile phones and/or computer-based Internet to meet sexual partners among black and Hispanic/Latino MSM in the United States.

    Methods: Black and Hispanic/Latino MSM (N = 853) were recruited from 3 US cities (Chicago, IL; Kansas City, MO; and Fort Lauderdale, FL) via online and community outreach. Read More

    Dorsal longitudinal foreskin cut is associated with reduced risk of HIV, syphilis and genital herpes in men: a cross-sectional study in Papua New Guinea.
    J Int AIDS Soc 2017 Apr;20(1):1-11
    Public Health Intervention Research Group, Kirby Institute, UNSW Australia, Sydney, Australia.
    Introduction: Various forms of penile foreskin cutting are practised in Papua New Guinea. In the context of an ecological association observed between HIV infection and the dorsal longitudinal foreskin cut, we undertook an investigation of this relationship at the individual level.

    Methods: We conducted a cross-sectional study among men attending voluntary confidential HIV counselling and testing clinics. Read More

    Community engagement in sexual health and uptake of HIV testing and syphilis testing among MSM in China: a cross-sectional online survey.
    • Authors:
    J Int AIDS Soc 2017 Feb;20(1):1-10
    Introduction: HIV and syphilis testing rates remain low among men who have sex with men (MSM) in low- and middle-income countries (LMICs). Community engagement has been increasingly used to promote HIV testing among key populations in high-income countries, often in settings with stronger civil society. This study aimed to assess socio-demographic, behavioural, and community engagement factors associated with HIV and syphilis testing among MSM in China. Read More

    Disparities in HIV and syphilis prevalence and risk factors between older male clients with and without steady sex partners in southwestern rural China.
    BMC Infect Dis 2017 Apr 12;17(1):269. Epub 2017 Apr 12.
    Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, No.18 Jinzhou Road, Nanning, Guangxi, China.
    Background: Heterosexual intercourse accounted for 93% of reported HIV cases in Guangxi, and Guangxi had 10% of China's total number of reported HIV cases. Older men are particularly vulnerable to STIs, for example, 46% of Guangxi's HIV cases were men over 50 years of age. As this is an under-studied population in China, effective prevention and control policies have yet to be developed. Read More

    Economic Disparities and Syphilis Incidence in Massachusetts, 2001-2013.
    Public Health Rep 2017 May/Jun;132(3):309-315. Epub 2017 Apr 12.
    1 Bureau of Infectious Disease and Laboratory Sciences, Massachusetts Department of Public Health, Boston, MA, USA.
    Objectives: We used area-level indicators of poverty to describe economic disparities in the incidence rate of infectious syphilis in Massachusetts to (1) determine whether methods developed in earlier AIDS analyses in Massachusetts could be applied to syphilis and (2) characterize syphilis trends during a time of increased rates of syphilis incidence.

    Methods: Using census tract data and population counts from the US Census Bureau and Massachusetts data on syphilis, we analyzed the incidence rate of syphilis infection from 2001 to 2013 by the poverty level of the census tract in which people with syphilis resided, stratified by age, sex, and race/ethnicity.

    Results: The syphilis incidence rate increased in all census tract groups in Massachusetts from 2001 to 2013, and disparities in incidence rates by area poverty level persisted over time. Read More

    The Great Impostor: Transaminitis Masking the Coinfection of Syphilis and Human Immunodeficiency Virus.
    Case Rep Med 2017 19;2017:2481961. Epub 2017 Mar 19.
    St. John Providence Southfield Hospital, Southfield, MI, USA.
    Introduction. The incidence of syphilis continues to rise in the United States over the past 15 years. This disease process is classified into stages and may present with a coinfection of Human Immunodeficiency Virus (HIV). Read More

    The PICASSO Cohort: baseline characteristics of a cohort of men who have sex with men and male-to-female transgender women at high risk for syphilis infection in Lima, Peru.
    BMC Infect Dis 2017 Apr 11;17(1):255. Epub 2017 Apr 11.
    David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.
    Background: Men who have sex with men (MSM) and male-to-female transgender women (transwomen) are disproportionately at risk of syphilis infection in Peru.

    Methods: From 2013 to 2014, MSM and transwomen seeking human immunodeficiency virus (HIV) or sexually transmitted infection (STI) testing and/or treatment were recruited into a 2-year observational cohort study to determine predictors of recently acquired syphilis infection (defined as a rapid plasma reagin [RPR] titer ≥1:16 and a reactive treponemal antibody test) in Lima, Peru. At baseline, interviewers collected sociodemographic, behavioral, and medical characteristics from participants. Read More

    Treponema pallidum ssp. pallidum identification by real-time PCR targetting the polA gene in paraffin-embedded samples positive by immunohistochemistry.
    Int J STD AIDS 2017 Jan 1:956462417704123. Epub 2017 Jan 1.
    5 Mycology Service, General Hospital Dr. Manuel Gea González, Tlalpan, Mexico.
    Syphilis is a systemic and sexually transmitted infection caused by Treponema pallidum ssp. pallidum. This spirochete causes different clinical and subclinical stages depending on the duration of infection and immune status of the host. Read More

    Update on syphilis and pregnancy.
    Birth Defects Res 2017 Mar;109(5):347-352
    Johns Hopkins Medicine, Department of Gynecology and Obstetrics, Baltimore, Maryland.
    While the origins of syphilis remain unknown, it has long been recognized as an infectious entity with complex pathophysiology. In this review, we highlighted the epidemiology and risk factors associated with syphilis. The incidence of syphilis in most populations showed a consistent upward trend until the 1940s with the introduction of penicillin as the preferred treatment. Read More

    Skin diseases of the vulva: Infectious diseases.
    J Obstet Gynaecol 2017 Apr 11:1-9. Epub 2017 Apr 11.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    A multitude of infectious diseases of viral (genital herpes, herpes zoster, genital warts and molluscum contagiosum), bacterial (syphilis, chancroid, lymphogranuloma venereum, donovanosis, erysipelas, cellulitis and necrotising fasciitis, folliculitis, impetigo, bartholin gland abscess, trichomycosis and erythrasma), fungal (candidiasis and dermatophytosis) and parasitic (pediculosis pubis) origin may affect the vulvar area. Herein, we review the infections and their skin manifestations in the vulvar area. Read More

    Assessment of the implementation of the infectious diseases screening programmes among pregnant women in the Lesser Poland region and comparison with similar programmes conducted in other European Union countries.
    Ginekol Pol 2017 ;88(3):151-155
    Department of Obstetrics and Gynecology, Jagiellonian University Medical College in Krakow, Poland.
    Objectives: The aim of the study was to assess the level of implementation of recommendations of the Ministry of Health regarding infectious disease screening during pregnancy.

    Material And Methods: The study included 477 patients who were admitted to the delivery room between December 2015 and February 2016. Data on screening test results were collected based on medical records covering the period before the admission. Read More

    State-Specific Rates of Primary and Secondary Syphilis Among Men Who Have Sex with Men - United States, 2015.
    MMWR Morb Mortal Wkly Rep 2017 Apr 7;66(13):349-354. Epub 2017 Apr 7.
    In 2015, the rate of reported primary and secondary syphilis in the United States was 7.5 cases per 100,000 population, nearly four times the previous lowest documented rate of 2.1 in 2000 (1). Read More

    Cerebrospinal Fluid Treponema pallidum Particle Agglutination Assay for Neurosyphilis Diagnosis.
    J Clin Microbiol 2017 Apr 5. Epub 2017 Apr 5.
    Departments of Neurology and Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA.
    Background: Limited data suggest that the cerebrospinal fluid (CSF) Treponema pallidum particle agglutination assay (TPPA) is sensitive and a CSF Treponema pallidum hemagglutination assay (TPHA) titer ≥1:640 is specific for neurosyphilis diagnosis.

    Methods: CSF-TPPA reactivity and titer were determined for a convenience sample of 191 CSFs from individuals enrolled in a study of CSF abnormalities in syphilis (training dataset). Sensitivity of a reactive test and specificity for reactivity at serial higher CSF dilutions was determined. Read More

    Trend and challenge in mother-to-child transmission of syphilis.
    Epidemiol Mikrobiol Imunol 2017 ;66(1):24-29
    Objective: The aim of the study was to evaluate the epidemiological trends in the incidence rates of mother-to-child transmission of syphilis, syphilis in women of reproductive age and pregnant women in the antenatal care program over the period 1991-2014, in order to find a basis for preventive measures.

    Material And Method: Case series data of confirmed syphilis was used to evaluate the incidence rates over the period 1991-2014 in Slovakia.

    Results: During the monitored period, 101 cases of mother-to-child transmitted syphilis were detected. Read More

    Prevention of Sexually Transmitted Diseases in HIV-Infected Individuals.
    Curr HIV/AIDS Rep 2017 Apr;14(2):41-46
    Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham School of Medicine, Tinsley Harrison Tower 215 1900 University Blvd., Birmingham, AL, 35294, USA.
    Prevention of sexually transmitted infections (STIs) is an important part of the care of the HIV-infected individual. STIs have been associated with increased risk of transmission and acquisition of HIV. Among HIV-infected persons, treatment failures and high recurrence rates of some STIs are more common. Read More

    Recurrent Donath-Landsteiner hemolytic anemia: a pediatric case report.
    Transfusion 2017 Mar 31. Epub 2017 Mar 31.
    Division of Pediatric Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
    Background: Paroxysmal cold hemoglobinuria (PCH) is a form of autoimmune hemolytic anemia caused by the Donath-Landsteiner antibody (D-L antibody). In children, this is typically a transient immune-mediated hemolysis that follows a viral illness and does not recur. Recurrent acute or chronic PCH due to D-L antibody is very rare. Read More

    Syphilization and Its Discontents: Experimental Inoculation against Syphilis at the London Lock Hospital.
    Bull Hist Med 2017 ;91(1):1-32
    In 1867 James Lane and George Gascoyen, surgeons to the London Lock Hospital, compiled a report on their experiments with a new and controversial treatment. The procedure, known as "syphilization," saw patients be inoculated with infective matter taken from a primary syphilitic ulcer or the artificial sores produced in another patient. Each patient received between 102 and 468 inoculations to determine whether syphilization could cure syphilis and produce immunity against reinfection. Read More

    Randomized Controlled Trial Evaluating a Standardized Strategy for Uveitis Etiologic Diagnosis (ULISSE).
    Am J Ophthalmol 2017 Mar 31. Epub 2017 Mar 31.
    Department of Internal Medicine, Hospices Civils de Lyon, Croix-Rousse Hospital, Lyon, France.
    Purpose: To prospectively assess the efficiency of a standardized diagnostic approach, compared to an open strategy, for the etiologic diagnosis of uveitis.

    Design: Noninferiority, prospective, multicenter, clustered randomized controlled trial.

    Methods: Consecutive patients with uveitis, who visited 1 of the participating departments of ophthalmology, were included. Read More

    The association between human perceived heat and early-stage syphilis and its variance: Results from a case-report system.
    Sci Total Environ 2017 Sep 30;593-594:773-778. Epub 2017 Mar 30.
    Department of Medical Statistics and Epidemiology & Health Information Research Center & Guangdong Key Laboratory of Medicine & Sun Yat-sen Global Health Institute, School of Public Health, Sun Yat-sen University, Guangdong Province 510080, China. Electronic address:
    Background: The relationship between temperature and syphilis is poorly understood despite clues and suggestions from previous studies. We examined the association between human perceived temperature (humidex) and the relative risk of early-stage syphilis in the most affected area of China, as well as its variance across social-economic status and age groups.

    Methods: Information regarding early-stage (primary and secondary) syphilis cases reported to the China Case Report System between 2005-2013 from Guangdong province was analyzed in this study. Read More

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