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    Evaluation of positive and false-positive results in syphilis screening of blood donors in Rio de Janeiro, Brazil.
    Transfus Med 2017 Feb 23. Epub 2017 Feb 23.
    Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, Brazil.
    Objectives: We propose to analyse the positive and false-positive results of treponemal and nontreponemal tests in blood donors from Brazil and to evaluate possible factors associated with the results of treponemal tests.

    Background: Treponemal tests have been used widely for syphilis screening in blood banks. The introduction of these tests in donor screening has caused an impact and a loss of donors who need to be assessed. Read More

    Alkaloid extracts from Combretum zeyheri inhibit the growth of Mycobacterium smegmatis.
    BMC Complement Altern Med 2017 Feb 23;17(1):124. Epub 2017 Feb 23.
    Department of Biochemistry, University of Zimbabwe, P.O. Box MP 167, Mt. Pleasant, Harare, Zimbabwe.
    Background: Current tuberculosis regimens have failed to combat the issue of drug resistance and ethno medicines may represent a possible source of antimycobacterial agents. Combretum species are well known in African traditional medicines and used for various ailments including pneumonia, venereal diseases like syphilis, mental problems, relief of sore throats and colds, fever, and chest coughs associated with tuberculosis. Alkaloids function as either hydrogen-acceptor or hydrogen-donor in hydrogen bonding critical for the interaction between targets thus, potentiating effects of curative agents on diseases. Read More

    Secondary Syphilis Showing Granulomatous Reaction not Responding To Conventional Doses of Penicillin.
    Indian J Dermatol Venereol Leprol 1979 Jul-Aug;45(4):294-296
    A case of secondary syphilis with granulomatous foci is reported. The patient did not respond to conventional doses of 2.4 mega units of benzathine penicillin but needed more than 12 mega units of penicillin for complete recovery. Read More

    Oesteolytic Lesions in Early Syphilis.
    Indian J Dermatol Venereol Leprol 1979 Mar-Apr;45(2):143-145
    A patient with osteolytic changes in the right clavicle and right acromio-clavicular joint due to early syphilis is reported. The rarity of such lesions in contrast to osteitis and periosteitis in early syphilis is emphasised. The need for awareness of the occurrence of such lesions in early lues is highlighted. Read More

    Gummatous Syphilis.
    Indian J Dermatol Venereol Leprol 1979 Sep-Oct;45(5):350-352
    A rare case of gummatous syphilis of the scalp involving underlying bones in a 50 years old male is reported. The diagnosis was confirme,d by history, clinical examination, serological and radiological findings. Salient radiological features regarding gummatous osteitis are described. Read More

    Ecology of Early Syphilis Patients: A Study of Eighty Cases.
    Indian J Dermatol Venereol Leprol 1979 Nov-Dec;45(6):436-441
    Eighty early syphilis patients were studied in detail regarding theirage, sourceof infection, occupation, education, marital status, income and previous venereal infection. Incidence of sexually transmitted disease was 27% of which 26.6% cases had early syphilis. Read More

    Prevalence of syphilis among female sex workers and their clients in Togo in 2011.
    BMC Public Health 2017 Feb 21;17(1):219. Epub 2017 Feb 21.
    Service de Dermatologie et IST, CHU Sylvanus Olympio, Université de Lomé, Lomé, Togo.
    Background: During the last ten years, a resurgence of syphilis has occurred in many countries worldwide, including Togo. Previous studies have shown a wide range of syphilis infection among the female sex workers (FSWs), from 1.5 to 42. Read More

    Prevalence of Hepatitis B Antigen/antibody in Patients of Syphilis.
    Indian J Dermatol Venereol Leprol 1980 Nov-Dec;46(6):335-337
    In some cases of Hepatitis B antigen positive hepatitis, a history of previous blood transfusion or any parenteral therapy is lacking and evidence for other routes of infections have to be sought. Sexual contact has been suggested as one of the methods of transmission of this infection. To approach the problem from this angle we studied 480 serawhich werepositive for syphilis serology for the presence of HB antigen and antibody by discontinuous counter immune electrophoresis method. Read More

    Status of HBsAg seroprevalence in 15 million rural couples in China: a cross-sectional study.
    Sci Rep 2017 Feb 21;7:42822. Epub 2017 Feb 21.
    Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.
    A cross-sectional analysis of prevalence of hepatitis B virus infection (HBV) among rural couples was conducted between 2010 and 2014. Serologic HBV markers, including hepatitis B surface antigen (HBsAg) and e antigen (HBeAg), were tested. Primary outcome of interest comprised HBsAg positivity in couples (both positive: F+M+, only wife positive: F+M-, only husband positive: F-M+), and secondary outcome consisted of prevalence and risk factors of HBsAg positivity among husbands or wives. Read More

    The big imitator strikes again: a case report of neurosyphilis in a patient with newly diagnosed HIV.
    Acta Clin Belg 2017 Feb 21:1-3. Epub 2017 Feb 21.
    a Department of Tropical Medicine , Antwerp University Hospital , Edegem , Belgium.
    Background: Neurosyphilis is the result of an infection of the central nervous system caused by the spirochete Treponema pallidum. Its clinical presentation includes meningovascular syphilis, tabes dorsalis, and dementia paralytica, resulting in a wide range of symptoms such as psychosis, Parkinsonism, and depression.

    Case Report: A 49-year-old male was admitted to a psychiatric hospital because of social withdrawal and self-neglect, indicative of a major depression. Read More

    An In Silico Identification of Common Putative Vaccine Candidates against Treponema pallidum: A Reverse Vaccinology and Subtractive Genomics Based Approach.
    Int J Mol Sci 2017 Feb 14;18(2). Epub 2017 Feb 14.
    Department of Immunology, Microbiology and Parasitology, Institute of Biological Sciences and Natural Sciences, Federal University of Triângulo Mineiro (UFTM), Uberaba 38025-180, MG, Brazil.
    Sexually transmitted infections (STIs) are caused by a wide variety of bacteria, viruses, and parasites that are transmitted from one person to another primarily by vaginal, anal, or oral sexual contact. Syphilis is a serious disease caused by a sexually transmitted infection. Syphilis is caused by the bacterium Treponema pallidum subspecies pallidum. Read More

    A Case of Syphilitic Uveitis in Which Vitreous Surgery Was Useful for the Diagnosis and Treatment.
    Case Rep Ophthalmol 2017 Jan-Apr;8(1):55-60. Epub 2017 Jan 26.
    Department of Ophthalmology, Osaka Medical College, Takatsuki City, Japan.
    Purpose: To report a case of atypical syphilitic uveitis complicated with retinal vasculitis, proliferative retinopathy, and vitreous hemorrhage in which vitreous surgery was useful for the diagnosis and treatment.

    Case Report: A 38-year-old female was referred to our hospital after noticing visual disturbance in her right eye. Fundoscopy examination of that eye revealed retinal phlebitis accompanied by retinal hemorrhage and soft exudate, and remarkable exudative changes in the retinal vessels from the upper arcade to the macula region. Read More

    HIV and STI s among men who have sex with men in Dodoma municipality, Tanzania: a cross-sectional study.
    Sex Transm Infect 2017 Feb 15. Epub 2017 Feb 15.
    Department of Behavioural Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
    Objectives: To determine the seroprevalence of HIV, STI and related risks among men who have sex with men (MSM) in Dodoma municipality, Tanzania.

    Methods: A cross-sectional study using respondent-driven sampling was employed to recruit study participants aged 18 years and above. Data on sociodemographics, HIV/STI knowledge and sexual practices were collected. Read More

    Wide variation in sexually transmitted infection testing and counselling at Aboriginal primary health care centres in Australia: analysis of longitudinal continuous quality improvement data.
    BMC Infect Dis 2017 Feb 15;17(1):148. Epub 2017 Feb 15.
    University Centre for Rural Health, University of Sydney, Lismore, NSW, Australia.
    Background: Chlamydia, gonorrhoea and syphilis are readily treatable sexually transmitted infections (STIs) which continue to occur at high rates in Australia, particularly among Aboriginal Australians. This study aimed to: explore the extent of variation in delivery of recommended STI screening investigations and counselling within Aboriginal primary health care (PHC) centres; identify the factors associated with variation in screening practices; and determine if provision of STI testing and counselling increased with participation in continuous quality improvement (CQI).

    Methods: Preventive health audits (n = 16,086) were conducted at 137 Aboriginal PHC centres participating in the Audit and Best Practice for Chronic Disease Program, 2005-2014. Read More

    Uveitis as an initial manifestation of acquired immunodeficiency syndrome.
    Int J STD AIDS 2017 Jan 1:956462417694569. Epub 2017 Jan 1.
    1 Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
    Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) is a multisystem disease that can involve the human eyes. Using ophthalmic examination records from January 2006 to November 2015, we retrospectively reviewed all patients who were diagnosed with HIV/AIDS in our hospital. The study was performed at a tertiary referral center in southern Taiwan. Read More

    Screening for asymptomatic neurosyphilis in HIV patients after treatment of early syphilis: an observational study.
    Sex Transm Infect 2017 Feb 14. Epub 2017 Feb 14.
    Department of Sexual Health and HIV, North Manchester General Hospital (Pennine Acute Hospitals NHS Trust), Crumpsall, Manchester, UK.
    Objective: To determine the prevalence of asymptomatic neurosyphilis (ANS) in HIV-positive individuals after treatment of early syphilis with single-dose benzathine penicillin G (BPG) or oral antibiotic alternatives.

    Methods: Patients at high risk of neurosyphilis (defined by serum rapid plasma reagin (RPR) titre ≥1:32 and/or peripheral blood CD4 lymphocyte count ≤350/μL) underwent lumbar puncture (LP) at a median time of 8.2 months post treatment. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Infectious Diseases and Immunizations in International Adoption.
    Pediatr Ann 2017 Feb;46(2):e56-e60
    Children who are adopted internationally have an increased risk of infectious diseases due to endemic conditions and variable access to preventive health care, such as vaccines, in their country of origin. Pediatricians and other providers who care for children should be familiar with the recommended screening for newly arrived international adoptees. Testing for gastrointestinal pathogens, tuberculosis, hepatitis, syphilis, and HIV should be routinely performed. Read More

    Primary chancre in the rectum: an underdiagnosed cause of rectal ulcer.
    Rev Esp Enferm Dig 2017 Feb 13;109. Epub 2017 Feb 13.
    Digestive Endoscopy Unit. Gastoenterology, Hospital Universitari i Politècnic La Fe, España.
    We report the case of a 35-year-old homosexual man with previous history of HIV, with primary chacre in the rectum. We believe this paper is significant because the diagnosis of rectal ulcer is more common in recent years, however rectal syphilis is a poorly recognized entity, especially with primary chancre formation. Read More

    Epidemiology of Acquired Immune Deficiency Syndrome and Cerebrovascular Disease in a Post Antiretroviral Era.
    J Stroke Cerebrovasc Dis 2017 Feb 8. Epub 2017 Feb 8.
    Michigan Stroke Network, Saint Joseph Mercy Oakland, Pontiac, Michigan. Electronic address:
    Background: People with acquired immune deficiency syndrome (AIDS) develop ischemic stroke through distinct mechanisms. These include infections such as syphilis, tuberculosis, varicella, and other conditions such as cocaine abuse, endocarditis, and hypercoagulability. The effect of improved awareness, detection, and treatment with highly active antiretroviral therapy (HAART) on the incidence and outcome of AIDS patients with stroke is unknown. Read More

    Unveiling of HIV dynamics among transgender women: a respondent-driven sampling study in Rio de Janeiro, Brazil.
    Lancet HIV 2017 Feb 7. Epub 2017 Feb 7.
    Bridge HIV, San Francisco Department of Public Health, San Francisco, CA, USA.
    Background: The burden of HIV in transgender women (transwomen) in Brazil remains unknown. We aimed to estimate HIV prevalence among transwomen in Rio de Janeiro and to identify predictors of newly diagnosed HIV infections.

    Methods: We recruited transwomen from Rio de Janeiro, Brazil, by respondent-driven sampling. Read More

    Diagnosis of some genital-tract infections: part 1. An historical perspective.
    Int J STD AIDS 2017 Jan 1:956462417693171. Epub 2017 Jan 1.
    3 School of Social and Community Medicine, University of Bristol, UK.
    Making a prompt and accurate diagnosis of genital tract infections is the key to instituting appropriate treatment and the linchpin of sexually transmitted infection control. We present a brief history, not covering syphilis, of diagnostic events for each of six bacteria and one protozoan from the time of discovery up to the molecular revolution. The latter is touched upon but its impact will form the substance of a further presentation. Read More

    Biomarker validation of self-reported sex among middle-aged female sex workers in China.
    Ann Epidemiol 2017 Jan 17. Epub 2017 Jan 17.
    School of Public Health, University of Maryland, College Park.
    Purpose: The objective of this study was to examine information bias arising from self-reported sexual activity and its association with syphilitic infections among female sex workers (FSWs) aged 35 years and older in China.

    Methods: A questionnaire was administered to 1245 middle-aged FSWs. Respondents self-reported sexual intercourse in the past 48 hours. Read More

    [Rapid diagnosis in serology].
    Enferm Infecc Microbiol Clin 2017 Feb 6. Epub 2017 Feb 6.
    Laboratorio de Serología y Arbovirus, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, España; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBER ESP), España.
    Serological diagnosis of acute phase infections implies the detection of IgM specific response, an effective marker of primary infection, but with less clinical significance in reactivations or reinfections. The aim of this article is to provide an updated view of the rapid diagnosis in serology by detecting the IgM isotype and reviewing its applications and limitations. Point-of-care (PoC) tests are analyzed. Read More

    [CXCL-13 as a biomarker in the diagnostics of neuroborreliosis].
    Nervenarzt 2017 Feb 9. Epub 2017 Feb 9.
    Abteilung für Neurologie, Universitätsklinikum St. Pölten, KLPU, Propst Führer-Straße 4, 3100, St. Pölten, Österreich.
    Background: The chemokine CXCL-13 is a potential intrathecal biomarker for neuroborreliosis (NB). According to the literature the sensitivity of CXCL-13 in the diagnostics of NB varies between 88% and 100% and the specificity between 63% and 99.7%. Read More

    Sexual risk behaviors, HIV, and syphilis among female sex workers in Nepal.
    HIV AIDS (Auckl) 2017 27;9:9-18. Epub 2017 Jan 27.
    Department of Mathematics and Computer Science, Prince of Songkla University, Pattani, Thailand.
    Purpose: Female sex workers (FSWs) are a key-affected population susceptible to acquiring HIV and sexually transmitted infections (STIs), as well as transmitting the virus to others. The aim of the study was to assess HIV and syphilis prevalence among FSWs in Nepal and to examine factors associated with it.

    Materials And Methods: The study was based on Integrated Biological and Behavioral Surveillance (IBBS) surveys among FSWs in Nepal from 2004 to 2015. Read More

    [Fever and hypotension after treatment of syphilis; the Jarisch-Herxheimer reaction].
    Ned Tijdschr Geneeskd 2017 ;161(0):D649
    Amphia Ziekenhuis, afd. Inwendige Geneeskunde, Breda.
    A 73-year-old man presented with fever and hypotension, which had developed a few hours after receiving treatment with benzyl-penicillin for secondary syphilis. These symptoms were due to the so-called Jarisch-Herxheimer reaction. The patient was admitted to hospital and treated with prednisone and intravenous fluids. Read More

    Sexually transmitted infection prevalence and related risk factors among heterosexual male methamphetamine users in China.
    Int J STD AIDS 2017 Jan 1:956462417693165. Epub 2017 Jan 1.
    4 Department of Dermatology, The Third hospital of Chengyang, Qingdao, China.
    Few studies have examined the association between methamphetamine (MA) abuse and sexually transmitted infection (STI) risk among heterosexual male MA users in China. A total of 288 heterosexual male MA users who met our inclusion criteria were recruited from nightclubs, KTVs, bars, bath centres and an STI clinic. STIs were screened among the participants, and the risk factors related to STIs were analysed by multivariate logistic regression in SPSS 11. Read More

    Demographics, Behaviors, and Sexual Health Characteristics of High Risk Men Who Have Sex With Men and Transgender Women Who Use Social Media to Meet Sex Partners in Lima, Peru.
    Sex Transm Dis 2017 Mar;44(3):143-148
    From the *Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX; †Center for Interdisciplinary Studies in Sexuality, AIDS and Society, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru; and ‡Division of Infectious Diseases, University of California, Los Angeles, CA.
    Background: Men who have sex with men (MSM) and transgender women (TW) in Peru bear a disproportionate burden of human immunodeficiency virus (HIV) and sexually transmitted infections (STIs). In a context of quickly expanding communication technology, increasing numbers of MSM and TW are using social media applications to seek sex partners. Understanding social media users and their sex partnering practices is needed to update HIV and STI prevention programming. Read More

    Risk Factors for Incidence of Sexually Transmitted Infections Among Women in a Human Immunodeficiency Virus Chemoprevention Trial: VOICE (MTN-003).
    Sex Transm Dis 2017 Mar;44(3):135-140
    From the *University of Zimbabwe-University of California San Francisco Research Program, Harare, Zimbabwe; †SCHARP at Fred Hutchinson Cancer Research Center; ‡Department of Biostatistics, University of Washington, Seattle, WA; §Magee-Women's Research Institute, Pittsburgh, PA; ¶Medical Research Council, HIV Prevention Research Unit, Durban, South Africa; ∥CAPRISA-University of KwaZulu Natal, Durban, South Africa; **MU-JHU Research Collaboration, Kampala, Uganda; ††Division of AIDS/NIAID/US National Institutes of Health, Bethesda, MD; ‡‡University of Pittsburgh, Pittsburgh, PA; and §§University of Alabama at Birmingham, AL.
    Background: In sub-Saharan Africa, there are limited data on the incidence of sexually transmitted infections (STIs) among women, largely because routine screening for asymptomatic infection is not performed. We conducted a secondary analysis to measure STI incidence rates and determine risk factors for new STI acquisition among women enrolled in the VOICE trial.

    Methods: We analyzed data from 4843 women screened for chlamydia, gonorrhoea, syphilis, and trichomonas infection at baseline, annually, at interim visits when clinically indicated and at their study termination visit. Read More

    Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.
    Protein Sci 2017 Feb 7. Epub 2017 Feb 7.
    Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
    The spirochete Treponema pallidum is the causative agent of syphilis, a sexually transmitted infection of major global importance. Other closely related subspecies of Treponema also are the etiological agents of the endemic treponematoses, such as yaws, pinta, and bejel. The inability of T. Read More

    Tuberculosis 'The Great Imitator': A usual disease with unusual presentations.
    Indian J Tuberc 2017 Jan 4;64(1):54-59. Epub 2016 Jul 4.
    Lecturer, Dept. of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.
    Background: A number of infectious diseases have been referred to by the phrase 'The Great Imitator', of which the oldest is syphilis; others include Lyme disease, nocardiosis, etc. Tuberculosis has been described as the second great imitator as it can imitate various other disease processes. An awareness of the atypical clinical manifestations of tuberculosis is important, especially in regions where tuberculosis continues to be a major public health problem, such as India. Read More

    A retrospective cross-sectional quantitative molecular approach in biological samples from patients with syphilis.
    Microb Pathog 2017 Feb 2;104:296-302. Epub 2017 Feb 2.
    Reference Laboratory of Bacterial Sexually Transmitted Infections, Department of Infectious Diseases, National Institute of Health, Av. Padre Cruz, 1649-016, Lisbon, Portugal; Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health, Av. Padre Cruz, 1649-016, Lisbon, Portugal. Electronic address:
    Syphilis is the sexually transmitted disease caused by Treponema pallidum, a pathogen highly adapted to the human host. As a multistage disease, syphilis presents distinct clinical manifestations that pose different implications for diagnosis. Nevertheless, the inherent factors leading to diverse disease progressions are still unknown. Read More

    HTLV-1 is predominantly sexually transmitted in Salvador, the city with the highest HTLV-1 prevalence in Brazil.
    PLoS One 2017 3;12(2):e0171303. Epub 2017 Feb 3.
    Centro Integrativo e Interdisciplinar de HTLV, Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil.
    Background: Salvador is the city with the highest number of HTLV-1 infected individuals in Brazil, yet the main route of HTLV-1 transmission is unknown.

    Objective: To investigate the association of syphilis infection as a proxy for sexual transmission of HTLV-1 infection in the general population of this city.

    Methods: A cross sectional population-based study was conducted with 3,451 serum samples obtained by a representative simple random sampling. Read More

    Clinico-Epidemiological Analysis of HIV/AIDS Patients.
    Eurasian J Med 2016 Oct;48(3):157-161
    Department of Infectious Diseases and Clinical Microbiology, Karadeniz Technical University School of Medicine, Trabzon, Turkey.
    Objective: The aim of this study was to examine clinico-epidemiological properties of HIV/AIDS patients.

    Materials And Methods: For this purpose, 115 HIV/AIDS patients monitored in our clinic between January 1, 1998, and December 31, 2013, were retrospectively evaluated.

    Results: For the 115 patients with a diagnosis of HIV/AIDS that we monitored, the mean age at the time of presentation was 34. Read More

    Educational intervention in Primary Care for the prevention of congenital syphilis.
    Rev Lat Am Enfermagem 2017 Jan 30;25:e2845. Epub 2017 Jan 30.
    PhD, Associate Professor, Escola Paulista de Enfermagem, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    Objectives:: to evaluate the efficiency of educational interventions related to the knowledge of health care professionals of Primary Care and to verify the impact on the vertical transmission rates of congenital syphilis.

    Method:: a quasi-experimental study conducted in the city of Londrina, Paraná, between 2013 and 2015. An educational intervention on diagnosis, treatment and notification was carried out with 102 professionals with knowledge measurement before and after the intervention. Read More

    Adherence to the follow-up of the newborn exposed to syphilis and factors associated with loss to follow-up.
    Rev Bras Epidemiol 2016 Oct-Dec;19(4):727-739
    Programa de Pós-graduação em Ciências da Saúde da Criança e Adolescente, Universidade Federal do Paraná - Curitiba (PR), Brasil.
    Introduction:: All newborns exposed to syphilis in pregnancy must have outpatient follow-up. The interruption of this follow-up especially threatens those children who were not treated at birth.

    Objective:: To describe the clinical, epidemiological, and sociodemographic characteristics of pregnant women with syphilis and their newborns, and to investigate the factors associated with the discontinuation of the follow-up. Read More

    A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum.
    Nat Commun 2017 Feb 1;8:14273. Epub 2017 Feb 1.
    Department of Biochemistry and Microbiology, University of Victoria, 3800 Finnerty Road, Victoria, British Columbia V8P 5C2, Canada.
    Syphilis is a prominent disease in low- and middle-income countries, and a re-emerging public health threat in high-income countries. Syphilis elimination will require development of an effective vaccine that has thus far remained elusive. Here we assess the vaccine potential of Tp0751, a vascular adhesin from the causative agent of syphilis, Treponema pallidum subsp. Read More

    Stages of syphilis in South China - a multilevel analysis of early diagnosis.
    BMC Public Health 2017 Jan 31;17(1):135. Epub 2017 Jan 31.
    Guangdong Provincial Center for Skin Diseases and STI Control, Guangzhou, China.
    Background: Early diagnosis of syphilis and timely treatment can effectively reduce ongoing syphilis transmission and morbidity. We examined the factors associated with the early diagnosis of syphilis to inform syphilis screening strategic planning.

    Methods: In an observational study, we analyzed reported syphilis cases in Guangdong Province, China (from 2014 to mid-2015) accessed from the national case-based surveillance system. Read More

    The immunological response to syphilis differs by HIV status; a prospective observational cohort study.
    BMC Infect Dis 2017 Jan 31;17(1):111. Epub 2017 Jan 31.
    Immunology Unit, Institute of Tropical Medicine,, Antwerp, Belgium.
    Background: It is not known if there is a difference in the immune response to syphilis between HIV-infected and uninfected individuals.

    Methods: We prospectively recruited all patients with a new diagnosis of syphilis and tested their plasma for IFNα, IFNγ, IL-1β, IL-12p40, IL-12p70, IP-10, MCP-1, MIP-1α, MIP-1β, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10 and IL-17A at baseline pre-treatment and 6 months following therapy.

    Results: A total of 79 HIV-infected [44 primary/secondary syphilis (PSS) and 35 latent syphilis (LS)] and 12 HIV-uninfected (10 PSS and 2 LS) cases of syphilis and 30 HIV-infected controls were included in the study. Read More

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