293,701 results match your criteria Synthetic Communications [Journal]
Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.
Department of Biochemistry & Molecular Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA.
Small-molecule and protein/antibody drugs mainly act on genome-derived proteins to exert pharmacological effects. RNA based therapies hold the promise to expand the range of druggable targets from proteins to RNAs and the genome, as evidenced by several RNA drugs approved for clinical practice and many others under active trials. While chemo-engineered RNA mimics have found their success in marketed drugs and continue dominating basic research and drug development, these molecules are usually conjugated with extensive and various modifications. Read More
Food Chem Toxicol 2018 Dec 3. Epub 2018 Dec 3.
Research Institute on Membrane Technology, Unit of Zeolite Membranes, ITM-CNR, University of Calabria, Cubo 17/c, 87036, Rende, Italy.
This paper deals with the design and manufacture of pure and hybrid synthetic (Mixed Matrix Membranes, MMMs) zeolite scaffolds (containing various amount of zeolite crystals dispersed in a polymeric matrix) to obtain new biomaterials. These scaffolds can potentially be used in the field of translational medicine to obtain innovative results to address tumorigenesis mechanisms with the promotion of an effort to deal with technical methods and information. Since olive oil has beneficial effects in healthy human cells and slows down and/or inhibits cell growth, the aim of this work was to monitor the protective and beneficial antitumor effects of olive oil in a new solid formulation (Spread Bio-Oil) on cancer cell cultured on zeolite scaffolds. Read More
Biotechnol Adv 2018 Dec 3. Epub 2018 Dec 3.
Department of Molecular Sciences, Macquarie University, Sydney, Australia; Biomolecular Discovery and Design Research Centre, Macquarie University, Sydney, Australia. Electronic address:
Single enzyme systems or engineered microbial hosts have been used for decades but the notion of assembling multiple enzymes into cell-free synthetic pathways is a relatively new development. The extensive possibilities that stem from this synthetic concept makes it a fast growing and potentially high impact field for biomanufacturing fine and platform chemicals, pharmaceuticals and biofuels. However, the translation of individual single enzymatic reactions into cell-free multi-enzyme pathways is not trivial. Read More
Res Microbiol 2018 Dec 3. Epub 2018 Dec 3.
Department of Biology of Bacteria, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland. Electronic address:
Infectious urolithiasis is a consequence of long-standing urinary tract infections with urease-positive bacteria, especially Proteus spp. However, because of the often mixed nature of urinary tract infections, in the case of urinary stones formation, several species of bacteria may be involved in the process. The purpose of the study was to determine the impact of the bacterial species: Escherichia coli, Klebsiella pneumoniae, Providencia stuartii, Pseudomonas aeruginosa and Staphylococcus aureus on the crystallization caused by Proteus mirabilis. Read More
Exp Neurol 2018 Dec 3. Epub 2018 Dec 3.
Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA. Electronic address:
Synthetic cathinones, often marketed as 'bath salts', have been reported to induce an excited delirium syndrome with characteristic symptoms such as paranoid, hallucination and even aggression. 3,4-Methylenedioxypyrovalerone (MDPV), a norepinephrine-dopamine reuptake inhibitor (NDRI), is one of the psychoactive ingredients in bath salts. The present study utilized cortical EEG and brain microdialysis in rats to compare the effects of MDPV (0. Read More
PLoS One 2018 6;13(12):e0208423. Epub 2018 Dec 6.
Department of Mathematics, College of Science, Beijing University of Chemical Technology, Beijing, China.
As the big data science develops, efficient methods are demanded for various data analysis. Granger causality provides the prime model for quantifying causal interactions. However, this theoretic model does not meet the requirement for real-world data analysis, because real-world time series are diverse whose models are usually unknown. Read More
PLoS One 2018 6;13(12):e0207376. Epub 2018 Dec 6.
Mechanics of Biological Membranes and Biorheology, Dpto. Química Física I, Universidad Complutense, Madrid, Spain.
We present a novel intensity-gradient based algorithm specifically designed for nanometer-segmentation of cell membrane contours obtained with high-resolution optical microscopy combined with high-velocity digital imaging. The algorithm relies on the image oversampling performance and computational power of graphical processing units (GPUs). Both, synthetic and experimental data are used to quantify the sub-pixel precision of the algorithm, whose analytic performance results comparatively higher than in previous methods. Read More
Environ Technol 2018 Dec 6:1-26. Epub 2018 Dec 6.
c Depestele, Teillage Vandecandelaère , 5 rue de l'Eglise, 14540 Bourguebus , France .
Filtration tests were carried out in laboratory columns filled with crushed sand with and without flax geotextiles to study the transfer and retention of soluble heavy metals. Divalent cations of copper, zinc and lead were simultaneously and continuously injected in filtration columns. Results show that, when geotextiles discs are present the retention of metals in sand is favoured and retention profiles are modified. Read More
Nat Prod Res 2018 Dec 6:1-16. Epub 2018 Dec 6.
a Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China , Hengyang , Hunan , PR China.
Flavan-3-ols are a series of natural products widely present in plants and show versatile biological activities. The structures of such compounds are characterized by owing two adjacent chiral centers and three rings. Their interesting structures and promising biological activities have driven increasing research developments toward the preparation of enantioenriched flavan-3-ols. Read More
FASEB J 2018 Dec 6:fj201801414R. Epub 2018 Dec 6.
Center for Microbial Ecology and Technology (CMET), Ghent University, Ghent, Belgium.
The intestinal epithelium plays an essential role in the balance between tolerant and protective immune responses to infectious agents. In vitro models do not typically consider the innate immune response and gut microbiome in detail, so these models do not fully mimic the physiologic aspects of the small intestine. We developed and characterized a long-term in vitro model containing enterocyte, goblet, and immune-like cells exposed to a synthetic microbial community representative of commensal inhabitants of the small intestine. Read More
Biomacromolecules 2018 Dec 6. Epub 2018 Dec 6.
In vitro polymerization of β-mannans is a challenging reaction due to the steric hindrance confered by the configuration of mannosyl residues and the thermodynamic instability of the β-anomer. Whatever the approach used to date - whether chemical, or enzymatic with glycosynthases and mannosyltransferases - pure β-1,4-mannans have never been synthesized in vitro. This has limited attempts to investigate their role in the production of plant and algal cell walls, in which they are highly abundant. Read More
Environ Sci Technol 2018 Dec 6. Epub 2018 Dec 6.
This study presents the first investigation of concentrations and congener group patterns of short- and medium-chain chlorinated paraffins (SCCPs and MCCPs) in 159 dust samples from plastic sports courts and synthetic turf in Beijing, China. The geometric mean concentration of SCCPs and MCCPs in dusts from plastic tracks (5429 and 15157 μg g-1) and basketball courts (5139 and 11878 μg g-1) were significantly higher than those from plastic tennis courts, badminton courts, and synthetic turf, meanwhile they were 1-3 orders of magnitude higher than those in dusts from other indoor environments. The friction between sneaker soles and plastic track materials may lead to the wear and decomposition of rubber, which may be an important source of chlorinated paraffins (CPs) in the dust from plastic tracks. Read More
Angew Chem Int Ed Engl 2018 Dec 6. Epub 2018 Dec 6.
Hubei University, College of Chemistry and Chemical Engineering, Youyi Avenue 368, 430062, Wuhan, CHINA.
Synthesis of free standing two-dimensional (2D) conjugated covalent organic framework (COF) films linked by C-C bonds can be considered as a holy grail of synthetic chemistry. However, reactions for their synthesis are quite rare. Herein we developed a very simple and mild strategy to synthesize them via the Nobel Prize reaction (Suzuki polymerization) on water/toluene interface in a fridge. Read More
New Phytol 2018 Dec 6. Epub 2018 Dec 6.
Department of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, UK.
High efficiency methods for DNA assembly have enabled routine assembly of synthetic DNAs of increased size and complexity. However, these techniques require customisation, elaborate vector sets or serial manipulations for the different stages of assembly. We have developed Loop assembly based on a recursive approach to DNA fabrication. Read More
J Neuroendocrinol 2018 Dec 6:e12667. Epub 2018 Dec 6.
Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, Toyama, 930-8555, Japan.
Sulfated cholecystokinin octapeptide (CCK-8s) is involved in feeding regulation as an anorexigenic neuropeptide in vertebrates. In rodents, intracerebroventricular (ICV) administration of CCK-8s has been shown to affect not only feeding behavior, but also psychomotor activity. However, there is still no information regarding the psychophysiological effects of CCK-8s in goldfish. Read More
Med Mycol 2018 Dec 6. Epub 2018 Dec 6.
Louisiana State University Health Sciences Center, Microbiology and Immunology.
Candida species are the second most frequent cause of fungal infections worldwide. Current knowledge of immunity to Candida has been gleaned almost exclusively from studies on Candida albicans, the most common disease-causing species. Knowledge of immunity to non-albicans Candida (NAC) species is still at an early stage due to the lack of tractable animal models with which to study these important pathogens. Read More
Bioinformatics 2018 Dec 5. Epub 2018 Dec 5.
Bioinformatics and Mathematical Biosciences Lab, Department of Agronomy, Horticulture and Plant Science, South Dakota State University, Brookings, SD, USA.
Motivation: The prediction of protein-protein interaction (PPI) sites is a key to mutation design, catalytic reaction, and the reconstruction of PPI networks. It is a challenging task considering the significant abundant sequences and the imbalance issue in samples.
Results: A new ensemble learning based method, EL-SMURF, was proposed for PPI sites prediction in this study. Read More
Org Biomol Chem 2018 Dec 6. Epub 2018 Dec 6.
Organic Synthesis and Process Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India.
Correction for 'A synthetic study toward the core structure of (-)-apicularen A' by Tapas R. Pradhan et al., Org. Read More
Chem Commun (Camb) 2018 Dec 6. Epub 2018 Dec 6.
Department of Chemistry, University of North Dakota, Grand Forks, ND 58202, USA.
Scalable synthesis of β-truxinic acid (CBDA-4) was accomplished by capturing and photodimerizing a metastable crystalline solid of trans-cinnamic acid. This synthetic approach builds a foundation for investigating the properties and applications of the useful diacid. The X-ray crystal structure of CBDA-4 was determined for the first time. Read More
Org Biomol Chem 2018 Dec 6. Epub 2018 Dec 6.
College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Republic of Korea.
An enantioselective synthetic route to hydroxywilfordic acid, a key subunit of sesquiterpene pyridine alkaloids such as wilfortrine, was developed. Asymmetric cyanation using Jacobsen's (R,R)-amino-thiourea and hydrolysis were performed to afford chiral α-hydroxy-α-methyl acid as the (S)-isomer. Naturally derived hydroxywilfordate prepared by methanolysis of wilfortrine was found to be the (R)-isomer upon comparison with the synthetic compound. Read More
Chem Commun (Camb) 2018 Dec 6. Epub 2018 Dec 6.
Department of Biochemistry, University of Maastricht, Cardiovascular Research Institute Maastricht (CARIM), Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
Selenocysteine scanning (SecScan) is a novel technique to map disulfide networks in proteins independent of structure-based distance information and mass spectrometry. SecScan applies systematic substitution of single Cys by Sec in combination with NMR spectroscopy for reliable and unambiguous determination of disulfide bond networks. Read More
J Am Chem Soc 2018 Dec 6. Epub 2018 Dec 6.
Enantioselective total syntheses of the anticancer isocarbostyril alkaloids (+)-7-deoxypancratistatin, (+)-pancratistatin, (+)-lycoricidine, and (+)-narciclasine are described. Our strategy for accessing this unique class of natural products is based on the development of a Ni-catalyzed dearomative trans-1,2-carboamination of benzene. The effectiveness of this dearomatization approach is notable, as only two additional olefin functionalizations are needed to construct the fully decorated aminocyclitol cores of these alkaloids. Read More
Nanotechnology 2019 Feb;30(5):055602
Applied Chemistry Key Lab of Hebei Province, Department of Bioengineering, Yanshan University, Qinhuangdao 066004, People's Republic of China. Asparagus Industry Technology Research Institute of Hebei Province, Qinhuangdao 066004, People's Republic of China.
A new type of vapreotide-templated Ag/Au bimetallic nanoshells (Vap@Ag/AuNSs) were successfully designed and fabricated based on polypeptide-directed mineralization and hierarchical self-assembly mechanisms under mild synthetic conditions. The nanoparticles with polypeptides serving as a core and coated Ag/Au bimetallic nanoshells exhibit diverse advantages, such as excellent biocompatibility, tumor targeting and low-cost. The Vap@Ag/AuNSs share excellent dispersibility, uniform size (120 nm) and a positive zeta potential (36. Read More
Med Chem 2018 Dec 5. Epub 2018 Dec 5.
Faculty of Agrobiotehnical Sciences Osijek, Josip Juraj Strossmayer University of Osijek, Osijek. Croatia.
Background: Rhodanine is known for its potential and important role in the medicinal chemistry since its derivatives exhibit a wide range of pharmacological activities such as antibacterial, antifungal, antidiabetic, antitubercular, anti-HIV, antiparasitic, antioxidant, anticancer, anti-proliferative and anthelmintic agents.
Objectives: Since N-substituted rhodanine synthons are rarely commercially available, it is desirable to develop a straight forward synthetic approach for the synthesis of these key building blocks. The objective was to synthesize a series of rhodanine derivatives and to investigate their antimicrobial and antioxidant activity. Read More
Curr Cancer Drug Targets 2018 Dec 5. Epub 2018 Dec 5.
Institute of Materia Medica, School of Pharmacy, Henan University, Jinming Road, Kaifeng, 475004. China.
Background: With the development of nanotechnology, nanocarrier has widely applied in such fields as drug delivery, diagnostic and medical imaging and engineering in recent years. Among all of the available nanocarrier, mesoporous silica nanoparticles (MSNs) have become a hot issue because of their unique properties, such as large surface area and voidage, tunable drug loading capacity and release kinetics, good biosafety and easily modified surface.
Objectives: We described the most recent progress in silica-assisted drug delivery and biomedical applications according to different types of Cargo in order to allow researchers to quickly learn about of the advance in this field. Read More
Comb Chem High Throughput Screen 2018 Dec 5. Epub 2018 Dec 5.
College of Information Engineering, Shanghai Maritime University, Shanghai 201306. China.
Aim And Objective: A metabolic pathway is an important type of biological pathway, which is composed of a series of chemical reactions. It provides essential molecules and energies for living organisms. To date, several metabolic pathways have been uncovered. Read More
Angew Chem Int Ed Engl 2018 Dec 6. Epub 2018 Dec 6.
National Institute of Advanced Industrial Science and Technology (AIST), 1-8-31 Midorigaoka, , 563-8577, Ikeda, JAPAN.
Large carbon networks featuring hierarchical pores and atomically dispersed metal sites (ADMSs) are ideal materials for energy storage and conversion due to the spatial-continuous conductive networks and highly active ADMSs. However, it is a challenge to synthesize such ADMS-decorated carbon networks. Here, we innovatively present a fusion-foaming methodology to puff up energetic metal-organic framework (EMOF) nanoparticles to submillimetric ADMS-decorated carbon networks via one-step pyrolysis. Read More
Cell Prolif 2018 Dec 5:e12552. Epub 2018 Dec 5.
Department of Urology, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.
With the development of synthetic biology, synthetic gene circuits have shown great applied potential in medicine, biology, and as commodity chemicals. An ultimate challenge in the construction of gene circuits is the lack of effective, programmable, secure and sequence-specific gene editing tools. The clustered regularly interspaced short palindromic repeat (CRISPR) system, a CRISPR-associated RNA-guided endonuclease Cas9 (CRISPR-associated protein 9)-targeted genome editing tool, has recently been applied in engineering gene circuits for its unique properties-operability, high efficiency and programmability. Read More
Anal Bioanal Chem 2018 Dec 6. Epub 2018 Dec 6.
National Center for Computational Toxicology, Office of Research & Development, US Environmental Protection Agency, Research Triangle Park, NC, 27711, USA.
In August 2015, the US Environmental Protection Agency (EPA) convened a workshop entitled "Advancing non-targeted analyses of xenobiotic chemicals in environmental and biological media." The purpose of the workshop was to bring together the foremost experts in non-targeted analysis (NTA) to discuss the state-of-the-science for generating, interpreting, and exchanging NTA measurement data. During the workshop, participants discussed potential designs for a collaborative project that would use EPA resources, including the ToxCast library of chemical substances, the DSSTox database, and the CompTox Chemicals Dashboard, to evaluate cutting-edge NTA methods. Read More
Anal Bioanal Chem 2018 Dec 6. Epub 2018 Dec 6.
Institute of Legal Medicine and Core Facility Metabolomics, Medical University of Innsbruck, Muellerstr. 44, 6020, Innsbruck, Austria.
Oral fluid is recognized as an important specimen for drug testing. Common applications are monitoring in substance abuse treatment programs, therapeutic drug monitoring, pain management, workplace drug testing, clinical toxicology, and driving under the influence of drugs (DRUID). In this study, we demonstrate that non-targeted LC-MS/MS with subsequent compound identification by tandem mass spectral library search is a valuable tool for comprehensive detection and confirmation of drugs in oral fluid samples. Read More
Methods Mol Biol 2019 ;1888:99-114
Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan.
An understanding of the intracellular distribution of bioactive small molecules provides insight into their target organelles and biomolecules, and throws light on their molecular mechanisms of action and specificity. Many studies in this area have employed fluorescence imaging, using molecules of interest labeled with fluorescent dyes. However, modification with a bulky fluorophore may significantly alter the properties, including bioactivity, of small molecules. Read More
Sci China Life Sci 2018 Nov 3. Epub 2018 Nov 3.
Shenzhen Key Laboratory of Synthetic Genomics and Center for Synthetic Genomics, Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Biol Trace Elem Res 2018 Dec 5. Epub 2018 Dec 5.
Centro de Química Inorgánica (CEQUINOR/CONICET, CICPBA, UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Bvd. 120 No. 1465, 1900, La Plata, Argentina.
The complex bis(4,7-dimethyl-1,10-phenantroline)sulfatooxidovanadium(IV), commonly known as Metvan, was prepared using a known synthetic procedure. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for a crystallographic study. The complex was also characterized by a detailed analysis of its infrared spectrum, supported by the theoretical calculations, and also by some data derived from its Raman spectrum. Read More
Heliyon 2018 Nov 22;4(11):e00936. Epub 2018 Nov 22.
King Abdullah University of Science and Technology (KAUST), BESE Division, The BioActives Lab, Thuwal, 23955-6900, Saudi Arabia.
Strigolactones (SLs), a novel class of plant hormones, are key regulator of plant architecture and mediator of biotic interactions in the rhizosphere. Root-released SLs initiate the establishment of arbuscular mycorrhizal (AM) symbiosis by inducing spore germination and hyphal branching in AM fungi (AMF). However, these compounds also trigger the germination of root parasitic weeds, paving the way for deleterious infestation. Read More
Data Brief 2018 Dec 3;21:1853-1857. Epub 2018 Nov 3.
National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
The data provided in this article are related to the research article entitled "Effect of Super Magnetic Nanoparticles Coated with Various Electric Charges on α-Synuclein Protein Fibrillation Process" (Javdani et al.). This article describes how electrically different charged and concentrated iron oxide nanoparticles synthesized using reverse co-precipitation method affects the fibrillation of albumin protein. Read More
Data Brief 2018 Dec 3;21:1833-1841. Epub 2018 Nov 3.
Carnegie Mellon University, United States.
This data article presents a data set comprised of 54 synthetic 3D equiaxed polycrystalline microstructures, the microstructural descriptors for each grain and the stress fields resulting from two sets of crystal plasticity simulations mimicking uniaxial tensile deformation to a total strain of 2%. This is related to the research article entitled "Applied Machine Learning to predict stress hotspots II: Hexagonal Close Packed Materials" (Mangal and Holm, 2018). The microstructures were created using an open source Dream. Read More
Biomed Res Int 2018 4;2018:9352130. Epub 2018 Nov 4.
Department of Medical, Surgical and Health Sciences, University of Trieste, Italy.
Aim: To evaluate, with three-dimensional analysis, the effectiveness of alveolar ridge preservation (ARP) after maxillary molar extraction in reducing alveolar bone resorption and maxillary sinus pneumatization when compared to unassisted socket healing.
Methods: Patients were included in the study following inclusion criteria and underwent minimally traumatic maxillary molar extraction followed by ARP using synthetic nanohydroxyapatite (Fisiograft Bone, Ghimas, Italy) (test group) or unassisted socket healing (control group). Cone-beam computerized tomographies (CBCT) were performed immediately after tooth extraction (T0) and 6 months postoperatively (T1). Read More
Biomed Res Int 2018 5;2018:8503427. Epub 2018 Nov 5.
Unit of Maxillo-Facial Surgery, University of Rome "Sapienza", Azienda Ospedaliera Universitaria "Sant'Andrea", Rome, Italy.
Traumatic, neoplastic, inflammatory, or infective dental removal promotes a gradual resorption process of bone which leads to a "nonuse" atrophy of the alveolar ridges. Many techniques allows restoring an appropriate bone thickness, but nowadays the attention is focused on the use of natural or synthetic grafts. Numerous studies have been conducted to develop and test new synthetic materials. Read More
Front Microbiol 2018 21;9:2827. Epub 2018 Nov 21.
Federal Research and Clinical Centre of Physical-Chemical Medicine, Moscow, Russia.
Prokaryotes are actively studied objects in the scope of genomic regulation. Microbiologists need special tools for complex analysis of data to study and identification of regulatory mechanism in bacteria and archaea. We developed a tool BAC-BROWSER, specifically for visualization and analysis of small prokaryotic genomes. Read More
Front Microbiol 2018 21;9:2825. Epub 2018 Nov 21.
Laboratory of Synthetic Microbiology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
Front Physiol 2018 21;9:1630. Epub 2018 Nov 21.
Team Evolution of Vertebrate Dentition, Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS UMR 5242, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Teeth and dentitions contain many morphological characters which give them a particularly important weight in comparative anatomy, systematics, physiology and ecology. As teeth are organs that contain the hardest mineralized tissues vertebrates can produce, their fossil remains are abundant and the study of their anatomy in fossil specimens is of major importance in evolutionary biology. Comparative anatomy has long favored studies of dental characters rather than features associated with tooth attachment and implantation. Read More
Front Cell Neurosci 2018 21;12:443. Epub 2018 Nov 21.
Ataxia Research Group, Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, United Kingdom.
Friedreich ataxia is a multi-system autosomal recessive inherited disorder primarily caused by homozygous GAA repeat expansion mutations within intron 1 of the frataxin gene. The resulting deficiency of frataxin protein leads to progressive mitochondrial dysfunction, oxidative stress, and cell death, with the main affected sites being the large sensory neurons of the dorsal root ganglia and the dentate nucleus of the cerebellum. The GAA repeat expansions may be pure (GAA) in sequence or may be interrupted with regions of non-GAA sequence. Read More
Diabetes Metab Syndr Obes 2018 8;11:699-705. Epub 2018 Nov 8.
Department of Modern Sciences and Technology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,
Obesity is a consequence of an imbalance between energy intake and energy expenditure. It affects people of both genders and all age groups, ethnicity and socioeconomic groups, and in developed and developing countries. Obesity is often accompanied by the metabolic syndrome (MetS). Read More
Nat Commun 2018 Dec 5;9(1):5182. Epub 2018 Dec 5.
Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1000, Ljubljana, Slovenia.
NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat domain is present in several innate immune receptors, where it is frequently responsible for sensing danger signals and regulation of activation. Here we show by reconstitution of truncated and chimeric variants into Nlrp3 macrophages that the leucine-rich repeat domain is dispensable for activation and self-regulation of NLRP3 by several different triggers. Read More
Oncogene 2018 Dec 5. Epub 2018 Dec 5.
Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Since inhibition of DNA replication can lead to replication fork stalling, resulting in DNA damage and apoptotic death, inhibitors of DNA replication are commonly used in cancer chemotherapy. Ribonucleotide reductase (RNR) is the rate-limiting enzyme in the biosynthesis of deoxyribonucleoside triphosphates (dNTPs) that are essential for DNA replication and DNA damage repair. Read More