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Ann Otol Rhinol Laryngol 2021 May 10:34894211014786. Epub 2021 May 10.

Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.

Introduction: Cancer predisposition syndromes are germline pathogenic variants in genes that greatly raise the risk of developing neoplastic diseases. One of the most well-known is Li-Fraumeni syndrome (LFS), which is due to pathogenic variants in the gene. Children with LFS have higher risks for multiple malignancies before adulthood, often with rare and aggressive subtypes. Read More

Mol Clin Oncol 2021 Jun 8;14(6):115. Epub 2021 Apr 8.

Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903-0125, Japan.

A 35-year-old man presented with a four-year history of a growing mass on the anterior aspect of his left elbow. Magnetic resonance imaging revealed a soft tissue tumor in the brachialis muscle extending to the cubital fossa. Following an open biopsy, the tumor was diagnosed as a monophasic fibrous synovial sarcoma. Read More

Pediatr Radiol 2021 Apr 9. Epub 2021 Apr 9.

Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 225 E. Chicago Ave., Chicago, IL, 60611, USA.

Background: The etiologies of pediatric solid intra-articular soft-tissue masses are not well described and can present diagnostic dilemmas.

Objective: Our hypothesis was that these entities have a limited differential diagnosis and are mostly benign.

Materials And Methods: We reviewed knee magnetic resonance imaging (MRI) scans performed at our tertiary care institution between 2001 and 2019 (n=3,915). Read More

Int J Surg Oncol 2021 24;2021:8871557. Epub 2021 Mar 24.

Department of Pathology, Hassan II University Hospital, Fez, Morocco.

Soft-tissue sarcomas are malignant tumors that require good management within specialized centers. Our study aims to assess the benefit of handling these kinds of tumors using the Multidisciplinary Meeting (MDM) approach. The current paper details this approach through a prospective study that has lasted for 42 months in the HASSAN II University Hospital Center, Fez, Morocco. Read More

Clin Nucl Med 2021 Mar 16. Epub 2021 Mar 16.

From the Departments of Radiology and Diagnostic Imaging Radiology and Diagnostic Imaging, Nuclear Medicine Unit Oncology Department, Istituto Ospedaliero Fondazione Poliambulanza, Brescia, Italy.

Abstract: Pericardial synovial sarcoma is a rare malignancy. We report the case of a patient who was referred to our institution for a large pericardial effusion requiring pericardiocentesis. CT imaging revealed an inhomogeneous pericardial mass beside the right atrium, and then a PET/CT scan was performed. Read More

J Cytol 2020 Oct-Dec;37(4):166-169. Epub 2020 Nov 6.

Department of Radio-Diagnosis and Imaging, Government Medical College, Jammu (J&K), India.

Background: Numerous pathological processes involve synovium and periarticular tissues that are characteristic and in some cases specific to a particular disease. Synovial fluid is a thick, stringy fluid found in the cavity of synovial joint. Examination of the synovium plays a key role in the diagnosis of many joint diseases. Read More

World J Clin Cases 2021 Mar;9(8):1893-1900

Department of Radiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, Shandong Province, China.

Background: Synovial sarcoma (SS) accounting for 6%-10% of primary soft tissue malignancies mainly occurs in deep soft tissue adjacent to joints of the limbs. Primary pulmonary SS (PPSS) is rare and has a poor prognosis. Cases of secondary distant metastases of PPSS occur rarely and there is a lack of corresponding imaging reports. Read More

J Cancer Res Ther 2021 Jan-Mar;17(1):13-21

Department of Radiology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Mediastinal masses span a wide histopathological and radiological spectrum. Apart from primary thymic/thyroid masses and lymphomas, all other mediastinal masses can be considered rare tumors. Chest radiography and Computed tomography (CT) are helpful to characterize the mass and can reach a diagnosis or a close differential diagnosis. Read More

Br J Radiol 2021 Apr 22;94(1120):20201389. Epub 2021 Feb 22.

Department of Radiology, Royal National Orthopaedic Hospital, Stanmore, UK.

Objective: To determine the differential diagnosis of intra-articular tumours and tumour-like lesions in a paediatric population compared to adults.

Methods: Retrospective review of children up to the age of 18 years with suspected intra-articular tumours and tumour-like lesions referred to a specialist musculoskeletal oncology service from January 2019 to August 2020. Data recorded included patient age and gender, lesion location and morphology (based on the classification system of Adams et al. Read More

Clin Imaging 2021 Feb 11;76:149-155. Epub 2021 Feb 11.

Department of Radiology, UT Southwestern, United States of America; Department of Orthopedic Surgery, UT Southwestern, United States of America.

Objectives: Synovial sarcomas commonly involve extremities. The purpose of this study was to systematically assess and describe the appearance of pathologically proven synovial sarcomas on conventional MR sequences, diffusion weighted imaging and dynamic contrast enhanced imaging.

Methods: In this cross-sectional retrospective study, fifteen pre-operative MRIs were analyzed separately by two musculoskeletal radiologists and a fellow. Read More

Cancers (Basel) 2021 Feb 1;13(3). Epub 2021 Feb 1.

Department of Orthopedic Surgery, Isala Hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands.

Surgery is the mainstay of treatment for localized soft tissue sarcomas (STS). The curative treatment highly depends on complete tumor resection, as positive margins are associated with local recurrence (LR) and prognosis. However, determining the tumor margin during surgery is challenging. Read More

J Cardiovasc Imaging 2021 Jan;29(1):84-85

Department of Pathology, New York University School of Medicine, New York, NY, USA.

BMJ Case Rep 2021 Jan 28;14(1). Epub 2021 Jan 28.

Orthopaedics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Synovial sarcomas are deep-seated, genetically distinct, malignant neoplasms seen in young adults, with a male preponderance. They have unusual clinical and pathological presentation and mimic many other sarcomas and carcinomas, making the diagnosis quite challenging. Although four variants are identified, occurrence in the hand is extremely rare and leads to significant morbidity. Read More

Rare Tumors 2020 27;12:2036361320983691. Epub 2020 Dec 27.

Department of Oncologic Surgery, Salah Azaiz Institute, Tunis, Tunisia.

Pancreatic metastases are rare, accounting for 2%-3% of pancreatic tumors. The pancreas represents an unusual metastatic site of synovial sarcoma (SS) outside the usual localizations (regional nodes, lung, bone, and liver). The diagnosis is evoked by the personnel medical history of SS and imaging then confirmed by histological examination of the guided pancreatic biopsy. Read More

Skeletal Radiol 2021 Jan 7. Epub 2021 Jan 7.

Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, HA7 4LP, UK.

Rare primary bone sarcomas are challenging entities both radiologically and pathologically. These include the diagnoses of spindle cell sarcoma (leiomyosarcoma, fibrosarcoma, synovial sarcoma, and malignant peripheral nerve sheath tumor), pleomorphic liposarcoma, and undifferentiated pleomorphic sarcoma. The radiographic and cross-sectional imaging features of each of these tumors are presented, along with current key pathological concepts. Read More

Clin Case Rep 2020 Dec 4;8(12):3520-3523. Epub 2020 Nov 4.

Department of Internal Medicine University of Florida Gainesville FL USA.

Abdominal pain can arise from numerous sources, including those extra-abdominal. It is important to obtain additional imaging in the setting of clinical suspicion for malignancy. Read More

Medicine (Baltimore) 2020 Dec;99(50):e23499

Department of Orthopedics.

Rationale: Synovial sarcoma (SS) is a soft tissue neoplasm that rarely occurs in the vertebral body and should be considered in the differential diagnosis in patients with SS and vertebral lesions. SS often presents as a painless mass in the spine, which may undergo slow enlargement, resulting in sustained symptoms of neurologic deficit and pain. Due to the difficulty in differentiating between SS from other soft tissue tumors and metastatic tumors, careful histological confirmation is required for definite diagnosis. Read More

BMJ Case Rep 2020 Nov 30;13(11). Epub 2020 Nov 30.

Department of Otorhinolaryngology, University of Malaya, Kuala Lumpur, Malaysia.

Head and neck synovial sarcoma is rare. We report the case of a 71-year-old man who presented with progressive dysphagia, odynophagia, shortness of breath on exertion and hoarseness of voice. Nasendoscopy revealed a smooth, non-fungating, non-ulcerative mass arising from the left lateral pharyngeal wall. Read More

Radiol Case Rep 2021 Jan 15;16(1):175-179. Epub 2020 Nov 15.

Department of Radiology, Department of pathology, Dubai Health Authority, Dubai, United Arab Emirates.

Pleuropulmonary synovial sarcoma is a subtype of synovial sarcomas that commonly arises from the chest wall, pleura, lungs and the heart. They are extremely rare, with only a few cases reported in the literature. It usually affects young and middle-aged adults with no gender predilection. Read More

BMJ Case Rep 2020 Nov 23;13(11). Epub 2020 Nov 23.

Department of Radiation Oncology, AIIMS Rishikesh, Rishikesh, Uttarakhand, India.

Primary synovial sarcoma of the lung (PSSL) is a rare tumour with only 0.5% incidence among other primary malignant lung tumours. Published medical literature regarding the natural history treatment protocol and clinical outcomes of PSSL remains limited. Read More

Int J Surg Case Rep 2020 22;77:333-336. Epub 2020 Oct 22.

Department of Urology, Taipei Medical University Hospital, No. 252, Wuxing Street, Taipei, 110, Taiwan. Electronic address:

Introduction: Synovial sarcoma (SS) is one of soft tissue sarcomas (STS), characterized by t(X;18)(p11;q11) chromosomal translocation. Clinical diagnosis of SS in groin is difficult owing to rarity and various manifestations. We reported a rare and interesting case of inguinal biphasic SS with initial impression of a vascular lesion. Read More

Eur J Radiol 2020 Dec 28;133:109376. Epub 2020 Oct 28.

St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA. Electronic address:

Purpose: To present a pictorial essay of paediatric primary synovial sarcomas from common and less documented anatomical locations. To review the literature for the imaging characteristics and prognostic factors of this rare but important childhood malignancy.

Method: 24 primary synovial sarcoma cases (17 male, 7 female with an age range 4-21 years) were reviewed in a collaborative effort between St Jude Children's Research Hospital and Great Ormond Street Hospital for Children. Read More

Intern Med 2021 Apr 28;60(8):1317-1318. Epub 2020 Oct 28.

Department of Gastroenterology and Hepatology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Japan.

Medicine (Baltimore) 2020 Oct;99(42):e22706

Department of Radiology, First Hospital of Jilin University.

Rationale: Synovial sarcoma (SS) is a malignant neoplasm that arises from soft tissues proximal to the joints. It occurs primarily at the major joints of the extremities, but may also occur in the deep soft tissues around the joints. While primary renal synovial sarcoma (PRSS) is extremely rare, it is important to have a better understanding of their imaging and clinical features to establish an effective treatment plan. Read More

Clin Imaging 2021 Jan 13;69:374-379. Epub 2020 Oct 13.

Department of Musculoskeletal Radiology, Royal Orthopaedic Hospital, Birmingham, UK. Electronic address:

Introduction: Mobile wad of Henry (MOH) is a preferred surgical term used to describe the lateral compartment muscles of the forearm consisting of brachioradialis, extensor carpi radialis longus and brevis. The lesions in this compartment are uncommon. In this paper, we describe the largest series of the MOH lesions including their demographics, imaging appearances and importance of surgical anatomy whilst managing MOH lesions via radiological or surgical interventions. Read More

Bull Cancer 2020 Nov 12;107(11):1186-1198. Epub 2020 Oct 12.

University Lille, CHU de Lille, service de chirurgie maxillo-faciale et stomatologie, U1008 - Controlled Drug Delivery Systems and Biomaterial, Inserm, 59000 Lille, France.

Benign and malign tumors can affect the temporomandibular joint (TMJ) as any other articulation. Nevertheless, TMJ tumors are rare and mostly benign. Their clinical expression is varied including symptomatology similar to TMJ dysfunctional disorders, otologic or neurologic pathologies. Read More

Eur Radiol 2021 Apr 10;31(4):2377-2383. Epub 2020 Oct 10.

Department of Imaging, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, HA7 4LP, UK.

Objective: To determine the prevalence of pulmonary metastases on re-staging chest CT at the time of first local recurrence (LR) of trunk or extremity soft tissue sarcoma (STS).

Materials And Methods: Retrospective review of all patients diagnosed with recurrent STS between May 2007 and April 2018. Data collected included patient age and sex, site of primary STS, time to LR, recurrence site, initial tumour grade, recurrent tumour grade, findings of initial staging chest CT, and prevalence of pulmonary metastases on re-staging chest CT. Read More

J Cutan Pathol 2021 Feb 11;48(2):263-268. Epub 2020 Oct 11.

Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.

Background And Aims: Synovial sarcoma (SS) is a spindled cell sarcoma demonstrating varying degrees of epithelial differentiation and characterized by a pathognomonic t(X;18) translocation. SS most frequently involves deep soft tissue of the extremities in young adults. Superficial SS involving dermis and/or subcutaneous tissue is exceedingly rare. Read More

Semin Ultrasound CT MR 2020 Oct 28;41(5):498-512. Epub 2020 May 28.

Department of Medical Imaging, University of Toronto, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

There is a broad spectrum of soft-tissue masses in children that can be challenging to diagnose clinically and on imaging. This article reviews the typical clinical and imaging findings of the most common and relevant benign, intermediate and malignant pediatric soft-tissue tumors in the following categories of the 2013 World Health Organization (WHO) classification: adipocytic tumors (lipoma, lipoblastoma, and liposarcoma), fibroblastic/myofibroblastic tumors (nodular fasciitis, myositis ossificans, fibrous hamartoma of infancy, fibromatosis colli, desmoid-type fibromatosis, lipofibromatosis, and infantile fibrosarcoma), pericytic tumors (myofibroma/myofibromatosis), skeletal muscle tumor (rhabdomyosarcoma), nerve sheath tumors (neurofibroma, malignant peripheral nerve sheath tumor), and uncertain differentiation (synovial sarcoma). In general, ultrasound and magnetic resonance imaging are used as first- and second-line imaging modalities, with limited roles for plain radiographs, computed tomography, and fluorodeoxyglucose-positron emission tomography. Read More

Clin Radiol 2021 Jan 28;76(1):78.e1-78.e8. Epub 2020 Sep 28.

Department of Radiology, Eye & ENT Hospital, Fudan University, Shanghai Medical College, Shanghai, 200031, PR China. Electronic address:

Aim: To explore the value of radiological and clinicopathological features in the diagnosis of sinonasal synovial sarcomas (SS).

Materials And Methods: Six patients with sinonasal SS were studied retrospectively using computed tomography (CT; n=6) and magnetic resonance imaging (MRI; n=4). The radiological and clinicopathological findings in this series were reviewed. Read More