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Skeletal Radiol 2019 Mar 22. Epub 2019 Mar 22.

Department of Radiology, University of Miami Miller School of Medicine/Jackson Memorial Hospital, 1611 NW 12th Ave, JMH WW 279, Miami, FL, 33136, USA.

Objective: To review histologic diagnoses of soft-tissue masses (STMs) ≤ 2 cm with indeterminate imaging features encountered in musculoskeletal oncology clinic at a tertiary referral center.

Materials And Methods: This was an IRB-approved retrospective review of patients with STMs ≤ 2 cm, referred to our tertiary care orthopedic oncology clinic over 4.75 consecutive years. Read More

Eklem Hastalik Cerrahisi 2019 Apr;30(1):24-31

Department of Orthopedics and Traumatology, University of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, 06200, Demetevler, Ankara, Turkey.

Objectives: This study aims to evaluate the clinical characteristics and treatment outcomes of patients with primary malignant tumors located in the proximal fibula.

Patients And Methods: This retrospective study included 23 patients (15 males, 8 females; mean age 22.1 years; range, 9 to 63 years) with primary malignant tumors located in the proximal fibula between May 2007 and May 2017. Read More

Int J Cancer 2019 Feb 18. Epub 2019 Feb 18.

Department of Plastic and Hand Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Soft tissue sarcomas (STS) are rare tumors of mesenchymal origin. About 50% of patients with STS experience relapse and more than 30% will die within 10 years after diagnosis. In this study we investigated circulating free DNA (cfDNA) and tumor-specific genetic alterations therein (circulating tumor DNA, ctDNA) as diagnostic biomarkers. Read More

BMC Cancer 2019 Feb 1;19(1):116. Epub 2019 Feb 1.

Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.

Background: Synovial sarcoma is a relatively rare type of soft tissue sarcoma. The commonly observed symptom is a deep-seated palpable mass accompanied by pain or tenderness. Thus, it is considered a soft tissue sarcoma and rarely occurs primarily in bone. Read More

Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Department of Pulmonary Medicine, Thoracic Center, St. Luke's International Hospital, Japan.

Chest radiography showed a right posterior mass on the mediastinum of an 84-year-old woman. The mass had been growing gradually for four years. Surgical excision was performed, and a pathological examination found the mass to be consistent with primary synovial sarcoma (SS) of the mediastinum. Read More

Clin Nucl Med 2019 Mar;44(3):259-261

From the Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, China.

A 48-year old man who underwent renal transplantation 2 years ago due to chronic renal failure underwent FDG PET/CT to determine the etiology of multiple lesions in the renal transplant incidentally found on routine examination. The images demonstrated several foci of the abnormally increased activity in the transplanted kidney with SUVmax of 7.5. Read More

J Egypt Natl Canc Inst 2018 Dec 24;30(4):173-176. Epub 2018 Nov 24.

ENT Department, Farhat Hached University Hospital, Sousse, Tunisia.

Synovial sarcoma is a malignant mesenchymal tumor. It most commonly occurs in the lower extremities of young adults. The head and neck are rare sites, accounting for less than 10%. Read More

J Knee Surg 2019 Apr 16;32(4):322-330. Epub 2018 Nov 16.

Department of Orthopedic Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina.

Intra-articular (IA) and peri-articular (PA) tumors of the knee are frequently encountered by orthopaedic surgeons. Nonetheless, due to the possibility of great morbidity and potential mortality, it is important to recognize and differentiate between benign and malignant lesions in a timely manner. Therefore, the purpose of this article is to provide a concise, practical, and updated review of commonly encountered IA and PA tumors including intratendinous gout, synovial chondromatosis, schwannoma, pigmented villonodular synovitis, and synovial sarcoma, and a detailed description of differentiating features to include various imaging modalities. Read More

Radiol Case Rep 2019 Feb 9;14(2):204-207. Epub 2018 Nov 9.

Department of Sarcoma, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA.

Synovial sarcoma typically presents as periarticular soft tissue mass in adolescent and young adult patients. Very rarely, soft tissue sarcomas may arise primarily within bone posing a significant diagnostic challenge as primary osseous malignancies such as osteosarcoma and metastatic disease are much more common. While tissue sampling with immunohistochemical and genetic testing are required for definitive diagnosis, radiologists and orthopedic oncologists should consider alternate etiologies when typical imaging features of more common bone tumors are not identified. Read More

Pan Afr Med J 2018 13;30:124. Epub 2018 Jun 13.

Service de Radiologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

We report the case of a 60-year old female patient, followed up for hypertensive heart disease for 04 years, presenting to the Dermatological Department with a mass in the right forearm which had evolved and gradually increased in size over the previous year. Clinical examination showed soft rounded, voluminous painless, tumor-like crusted ulcerative lesion measuring 8 cm in large-diameter, fixed with respect to both planes, at the level of the mid-parts of the posterolateral area of the right forearm (A). Standard X-ray showed homogeneous opaque mass with sparing of the opposite cortex (B). Read More

Medicine (Baltimore) 2018 Sep;97(39):e12040

Department of Hematology-Oncology.

Rationale: Prostate sarcoma has been reported to represent 0.7% of primary prostate malignancies. Leiomyosarcoma and rhabdomyosarcoma are the most common sarcomas of the prostate. Read More

Mol Clin Oncol 2018 Oct 20;9(4):464-466. Epub 2018 Aug 20.

Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

Intra-articular primary soft tissue sarcomas are extremely rare. The present case report describes a case of intra-articular synovial sarcoma of the ankle joint. A 51-year-old man presented with complaints of swelling and progressive pain in the right ankle. Read More

Radiol Case Rep 2018 Oct 19;13(5):1087-1090. Epub 2018 May 19.

University of Texas Medical Branch 301 University Boulevard, Galveston, Texas, 77555, USA.

Parapharyngeal space sarcomas are rare malignancies and most in the reported literature are synovial sarcomas. Here we present the case of a 27-year-old female with a painless, left-sided neck mass who underwent computed tomography and magnetic resonance imaging evaluation which demonstrated a benign appearing mass that upon resection unexpectedly proved to be a high-grade undifferentiated sarcoma with rhabdoid features. Staging computed tomography revealed a synchronous renal cell carcinoma with clear cell and papillary features. Read More

PET Clin 2018 Oct;13(4):609-621

Keck School of Medicine, University of Southern California (USC), 1520 San Pablo Street, Suite L1600, Los Angeles, CA 90033.

Soft tissue sarcomas (STSs) account for less than 1% of adult solid tumors and about 7% of pediatric malignancies, causing 2% of cancer-related deaths. With the advent of PET-computed tomography (CT), the value of (18) fluorine-2-fluoro-2-deoxy-d-glucose (FDG) PET imaging to improve the management of STSs has been explored. FDG PET imaging has been found useful in restaging and treatment response assessment. Read More

Kyobu Geka 2018 Aug;71(8):637-639

Inoue Hospital, Fukuyama, Japan.

A 66-year-old man was referred to our hospital for an abnormal shadow. Chest computed tomography (CT)showed a heterogeneous mass with well-defined border in the right S10and ipsilateral pleural effusion. Fluorodeoxyglucose-positron emission tomography(FDG-PET)showed the accumulation in the mass and pleural effusion. Read More

World J Surg Oncol 2018 Aug 27;16(1):175. Epub 2018 Aug 27.

Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China.

Background: Synovial sarcoma (SS) is a soft tissue sarcoma that rarely occurs in the spine, and a minimal number of cases have been reported in the literature. Spinal SS is challenging in diagnosis and treatment and has a poor prognosis. The aim of this study was to summarize and analyse the clinical features and outcomes of patients with spinal SS. Read More

Case Rep Orthop 2018 26;2018:8790916. Epub 2018 Jul 26.

Zentrum für Orthopädie und Unfallchirurgie, Städtisches Klinikum Saarbrücken, Saarbrücken, Germany.

We present a case of a 70-year-old male patient with an untypical gout infiltration of the peroneal tendons mimicking synovial sarcoma. The patient had a negative history of gout at initial presentation in our department. Magnetic resonance imaging of the region revealed a finding highly suspicious for synovial sarcoma of the peroneal tendons. Read More

Indian J Cancer 2018 Jan-Mar;55(1):37-44

Department of Surgical Pathology, Bone and Soft Tissues, Disease Management Group (DMG), Tata Memorial Hospital, Mumbai, Maharashtra, India.

Introduction: Primary bone and soft tissue sarcomas are rare, but diagnostically and therapeutically challenging group of tumors, requiring multidisciplinary management. There are limited documented studies from multidisciplinary teams , in the form of comprehensive analysis of these tumors, from our country. This study is an analysis of cases of osteosarcomas, Ewing sarcomas (ESs), chondrosarcomas (CSs), and soft-tissue sarcomas (STSs), registered at our institution during 2012. Read More

Clin Sarcoma Res 2018 9;8. Epub 2018 Apr 9.

1Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, Oxford, OX3 7LE UK.

Background: The use of F-FDG PET-CT (PET-CT) is widespread in many cancer types compared to sarcoma. We report a large retrospective audit of PET-CT in bone and soft tissue sarcoma with varied grade in a single multi-disciplinary centre. We also sought to answer three questions. Read More

Eur J Surg Oncol 2019 02 20;45(2):254-260. Epub 2018 Jul 20.

Oncology Service, Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Northfield, B31 2AP Birmingham, United Kingdom. Electronic address:

Objectives: Synovial sarcoma, a distinct subtype of soft tissue sarcomas (STS), is typically found in young patients. Long history of symptoms and heterogeneous clinical presentation sometimes delays diagnosis. Children have been reported to have a better prognosis than adults in some series. Read More

J Orthop Sci 2018 Nov 21;23(6):1045-1050. Epub 2018 Jul 21.

Department of Orthopedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 7008558, Japan. Electronic address:

Background: Although emerging evidence has suggested that computer-assisted navigation allows surgeons to plan the optimal level of resection without compromising the surgical margins, the precise accuracy of the procedures has been unclear. The aim of this study was to investigate the accuracy and safety of the musculoskeletal tumor resection using O-arm/Stealth intraoperative navigation assistance.

Methods: A retrospective study of six patients with bone and soft tissue tumors who underwent surgical resection using O-arm/Stealth navigation system was performed. Read More

BMJ Case Rep 2018 Jul 18;2018. Epub 2018 Jul 18.

Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare soft tissue sarcoma which was initially observed in acral sites and characterised by spindle cells, pleomorphic bizarre cells and distinctive large Reed-Sternberg-like cells admixed with an intense inflammatory cell infiltrates. MIFS manifests as a slow growing often superficial lesion which can be mistaken as infectious or chronic inflammatory process or benign tumours such as nodular fasciitis, giant cell tumour of tendon sheath or synovial pseudocyst. We report a rare presentation of a MIFS in a 38-year-old man with extensive local spread from subcutaneous tissue to the ankle joint and bones as well as multiple synchronous metastases to lung, sixth rib and vertebra. Read More

J Cardiothorac Surg 2018 Jul 3;13(1):84. Epub 2018 Jul 3.

Department of Cardiovascular Sciences, Catholic University of Sacred Heart, Rome, Italy.

Background: Primary heart sarcomas are exceedingly rare tumors. Among primary cardiac sarcomas, synovial sarcoma is one of the rarest, involving cardiac cavities or pericardium.

Case Presentation: Two cases of synovial sarcoma are presented with the clinical course and therapy. Read More

Cancer Sci 2018 Jul 27;109(7):2302-2309. Epub 2018 Jun 27.

Radiation and Cancer Biology Team, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.

Synovial sarcoma (SS) is a rare yet refractory soft-tissue sarcoma that predominantly affects young adults. We show in a mouse model that radioimmunotherapy (RIT) with an α-particle emitting anti-Frizzled homolog 10 (FZD10) antibody, synthesized using the α-emitter radionuclide astatine-211 ( At-OTSA101), suppresses the growth of SS xenografts more efficiently than the corresponding β-particle emitting anti-FZD10 antibody conjugated with the β-emitter yettrium-90 ( Y-OTSA101). In biodistribution analysis, At was increased in the SS xenografts but decreased in other tissues up to 1 day after injection as time proceeded, albeit with a relatively higher uptake in the stomach. Read More

J Cancer Res Ther 2018 Apr-Jun;14(3):481-489

Department of Pulmonary Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Synovial sarcoma (SS) is a malignant mesenchymal tumor with variable epithelial differentiation that affects mostly young adults and can arise at any anatomic site. Primary intrathoracic SS is very rare accounting for <0.5% of all lung tumors. Read More

J Card Surg 2018 Jul 10;33(7):391-392. Epub 2018 Jun 10.

Department of Cardiac Surgery, University Hospital of Antwerp, Edegem, Antwerp, Belgium.

Case Rep Pulmonol 2018 4;2018:5190271. Epub 2018 Apr 4.

Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

Primary pleuropulmonary synovial sarcoma is extremely rare. The diagnosis can only be made after having eliminated an extrapleuropulmonary localization in the past and at the time of diagnosis. Our presentation is about a 40-year-old woman having a cough and dyspnea since three weeks ago; imaging had showed a left pleurisy with pleuropulmonary process. Read More

Asia Pac J Clin Oncol 2019 Feb 28;15(1):38-47. Epub 2018 May 28.

Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Aim: Fluorescence in situ hybridization (FISH) is an important ancillary tool for the classification of bone/soft tissue (BST) tumors. The aim of this study was to evaluate the contribution of FISH to the final classification of common BST entities in the molecular pathology department of the Royal Prince Alfred Hospital (RPAH), which is one of the most important referral centers for the management of sarcomas in Australia.

Methods: All routine diagnostic FISH tests performed on BST formalin-fixed paraffin embedded (FFPE) tissue specimens at the RPAH in a 5-year period (February, 2010-November, 2015) were reviewed. Read More

J Long Term Eff Med Implants 2018 ;28(1):47-53

Division of Adult Reconstruction, SUNY Downstate Medical Center, Brooklyn, New York; Department of Orthopaedic Surgery and Rehabilitation Medicine, SUNY Downstate Medical Center, Brooklyn, New York.

Milwaukee Shoulder Syndrome (MSS) is a painful progressive arthropathy in which hydroxyapatite crystal deposition in synovial tissue induces lysosomal release of collagenase and neutral proteases. These enzymes are destructive to periarticular tissue, including the synovium, articular cartilage, rotator cuff muscles, and the intrasynovial cortical bone. MSS predominantly occurring in women (90%) over the age of 70 years of age with a clinical history marked by recurrent joint effusions and pain, which classically worsens at night. Read More

Sultan Qaboos Univ Med J 2018 Feb 4;18(1):e93-e96. Epub 2018 Apr 4.

Department of Orthopaedics & Traumatology, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Synovial haemangiomas are rare benign vascular proliferations arising in synovium-lined surfaces. While the knee is by far the joint most commonly involved, this condition can also occur in the elbow. We report an eight-year-old boy who presented to the National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia, in 2016 with a left elbow swelling of one year's duration. Read More

Ann Diagn Pathol 2018 Jun 29;34:1-12. Epub 2017 Nov 29.

Pathology Department, University of Valencia, Valencia, Spain.

Background: Despite extensive immunohistochemical (IHC) and molecular studies combined with morphologic findings, a group of round/ovoid cell tumors histologically similar to Ewing sarcomas (ES) but lacking EWSR1-rearrangements may remain unclassifiable.

Design: We retrospectively analyzed 41 Ewing-like tumors (formalin-fixed, paraffin-embedded) previously determined as negative or non-informative for EWSR1-rearrangements by FISH and/or RT-PCR. A new histopathology revision and additional IHC and molecular analyses were carried out in order to investigate whether additional IHC and/or molecular testing in combination with the morphological findings may help in reaching a definitive diagnosis. Read More

PLoS One 2018 16;13(4):e0195289. Epub 2018 Apr 16.

Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.

Purpose: Radio-hyperthermo-chemo (RHC) therapy, which combines radiotherapy, hyperthermia, and chemotherapy, for malignant soft tissue tumors has been introduced with the aim of decreasing the possibility of local recurrence after surgery. To avoid unnecessary neoadjuvant therapy and to plan the appropriate surgical treatment, surveillance of RHC therapeutic efficacy during treatment is necessary. In this study, we determined the optimal response criteria to evaluate the efficacy of RHC by comparing preoperative images before and after RHC with pathological evaluation of necrosis in the resected tumor. Read More

Bol Med Hosp Infant Mex 2018 ;75(1):31-40

Departamento de Medicina Nuclear e Imagen Molecular, Instituto Nacional de Cancerología. Ciudad de México, México.

Background: Imaging studies, particularly simple and contrast-enhanced tomography, constitute the first diagnostic approach to detect recurrence of musculoskeletal tumors. The aim of the present retrospective study was to demonstrate the usefulness of scintigraphy plus SPECT/CT (single photon emission computed tomography) with thallium-201 (Tl) in the evaluation of malignant musculoskeletal tumors with suspicion of recurrence or metastatic disease.

Methods: Eight weeks after the last therapy, 72 scintigraphy and SPECT/CT studies were performed to assess regional recurrence and metastatic disease in 42 patients with different types of malignant musculoskeletal tumors, such as osteosarcoma, Ewing's sarcoma, rhabdomyosarcoma, retinoblastoma, synovial sarcoma, and Wilms tumor at the Hospital Infantil de México Federico Gómez. Read More

BMJ Case Rep 2018 Mar 30;2018. Epub 2018 Mar 30.

Colon and Rectal Surgery, St. Joseph Mercy Ann Arbor, Ypsilanti, Michigan, USA.

We report a third case of a primary intramural synovial sarcoma of the lower gastrointestinal tract. A 50-year-old woman presented with hematochezia, dizziness and shortness of breath. CT imaging revealed a transverse colo-colonic intussusception with a colonic mass serving as a lead point. Read More

Ulster Med J 2017 09 12;86(3):204-205. Epub 2017 Sep 12.

Royal Victoria Hospital, 274 Grosvenor Road, Belfast BT12 6BA.

J Cancer Res Ther 2018 ;14(Supplement):S267-S269

Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

Synovial sarcomas (SSs) are very rare, poorly studied tumors that generally occurs around joint and muscle tendons. Primary SSs of the kidney are even rarer, accounting for <2% of all malignant renal tumors. We report the case of a 44-year-old man who was diagnosed with primary renal SS on the basis of imaging, histopathological, and immunohistochemical examination. Read More

Urology 2018 Jun 19;116:e7-e8. Epub 2018 Mar 19.

Department of Pathology, The Gujarat Cancer and Research Institute, Ahmedabad, India.

Primary renal synovial sarcoma (PRSS) is a rare entity. It should be considered as one of the differential diagnoses of spindle cell tumors of the kidney. Immunohistochemistry and genetic translocation studies should be used to confirm the diagnosis. Read More

World J Gastroenterol 2018 Feb;24(8):949-956

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan.

Synovial sarcoma (SS) is genetically characterized by chromosomal translocation, which generates fusion transcripts. Although SS can occur in any body part, primary gastric SS is substantially rare. Here we describe a detection of the fusion gene sequence of gastric SS in plasma cell-free DNA (cfDNA). Read More

Medicine (Baltimore) 2018 Feb;97(8):e9870

Department of Radiology, the Third Hospital of Hebei Medical University.

Rationale: Undifferentiated high-grade pleomorphic sarcoma (UPS), originated from bone, is a rare tumor, accounting for 2% to 5% of all primary maligment bone neoplasms. Skip lesion can be found in undifferentiated high-grade pleomorphic sarcoma of bone (UPS-B). However, the direct invasion across the articular synovium to bone has not been reported previously. Read More

Ann Thorac Surg 2018 03;105(3):e129-e131

Division of Thoracic Surgery, Department of Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

We report a rare case of primary pulmonary synovial sarcoma that underwent spontaneous regression after a transbronchial biopsy. A 38-year-old woman with a well-demarcated solitary mass shadow on chest roentgenogram was referred to us. A transbronchial biopsy was performed, and immunohistochemical results as well as detection of SYT-SSX1 (SYnovial sarcoma Translocation-Synovial Sarcoma X chromosome breakpoint) transcripts resulted in a diagnosis of synovial sarcoma. Read More

Onco Targets Ther 2018 23;11:483-488. Epub 2018 Jan 23.

Department of Otorhinolaryngology - Head and Neck Surgery, Keio University, School of Medicine.

This paper presents an extremely rare case of synovial sarcoma arising from the maxillary sinus, which resulted in a clinically complete response to chemotherapy. Synovial sarcoma is a rare soft tissue malignant tumor, most commonly affecting the extremities. While ~10% occur in the head and neck region, synovial sarcoma of the sinonasal tract is extremely rare, with only 11 cases having been reported previously. Read More

Int J Surg Pathol 2018 Aug 16;26(5):469-474. Epub 2018 Jan 16.

1 Instituto Nacional de Cancerología, México City, México.

Synovial sarcoma is a ubiquitous neoplasm predominantly affecting soft tissues of young adults of any gender; few cases have been described in the digestive system, mostly in the stomach. The (X;18)(p11.2; q11. Read More

PM R 2018 Sep 10;10(9):969-973. Epub 2018 Jan 10.

Carolina Neurosurgery and Spine Associates, 9735 Kincey Ave, #300, Huntersville, NC 28078(†). Electronic address:

Synovial sarcoma is a slow-growing, intermediate- to high-grade neoplasm with extensive metastatic potential. Accurate diagnosis of synovial sarcoma may pose a challenge to providers because of its indolent growth and variable presentation. The findings of a soft-tissue, periarticular mass with calcifications in a young patient are highly suggestive of synovial sarcoma. Read More

Pan Afr Med J 2017 27;28:86. Epub 2017 Sep 27.

Service de Traumatologie Orthopédie de l'Hôpital Militaire Avicenne, Marrakech, Maroc.

Pigmented villonodular synovitis (PVNS) is a rare benign proliferation of synovial joints, serous bursa, tendinous sheaths of unknown etiopathogeny. We here report 20 cases of PVNS of the knee recorded at the Avicenne Military Hospital, Marrakech over a period of 9 years, from January 2000 to December 2009. This study aimed to identify the specific features of this lesion and to examine its anatomoclinic and prognostic aspects. Read More

Am J Med Sci 2017 Nov 15;354(5):523-526. Epub 2017 Mar 15.

Internal Medicine, Saint Joseph's Regional Medical Center, Paterson, New Jersey.

Indian J Nucl Med 2017 Oct-Dec;32(4):340-342

Department of Radiology Imaging Services, Health Care Global Cancer Centre, Ahmedabad, Gujarat, India.

Primary pleuropulmonary synovial sarcoma, a mesenchymal tumor of lung and pleura, is very rare and highly aggressive condition among the primary lung malignancies. As role of fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) has been established in lung malignancies in terms of staging, restaging, biopsy guidance, and treatment response evaluation, there is also role of FDG PET-contrast-enhanced CT (CECT) to raise suspicion or increase confidence in reporting of sarcomatous lung malignancy by studying characteristics of CECT scan features. We present a case of a 57-year-old female patient having large lung mass, who underwent FDG PET-CT scan and findings raised strong suspicious of noncarcinomatous pattern of lung mass and may have sarcomatous primary lung malignancy which was later proven on histopathological and immunohistochemistry report. Read More

J Foot Ankle Surg 2018 Mar - Apr;57(2):388-392. Epub 2017 Nov 3.

Associate Professor, Department of Pathology, University of Notre Dame, Fremantle, WA, Australia.

Synovial sarcoma is a rare occurrence in the lower extremity, although the presenting symptoms can mimic those of other more common and benign musculoskeletal pathologies. We present the case of a patient who was originally thought to have a Morton's neuroma or ganglionic cyst. The correct diagnosis, synovial sarcoma, was determined only after an unplanned excision. Read More

Cardiol Clin 2017 Nov 6;35(4):589-600. Epub 2017 Sep 6.

Department of Cardiovascular Diseases, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Division of Cardiac Radiology, Department of Radiology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.

Pericardial tumors are rare lesions that include a range of neoplastic conditions that may arise within the pericardium or metastasize to involve it secondarily. Understanding the spectrum of lesions that are included in the differential diagnosis of a pericardial mass-lesion is critical to making timely, accurate diagnoses and getting the appropriate therapy should one be necessary. This review summarizes the radiologic and pathologic findings of the most commonly encountered of these entities. Read More

Case Rep Oncol 2017 May-Aug;10(2):660-665. Epub 2017 Jul 14.

Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Primary pleuropulmonary synovial sarcomas are quite rare, representing 0.1-0.5% of all pulmonary malignancies. Read More

Mol Cancer Res 2017 12 29;15(12):1733-1740. Epub 2017 Aug 29.

Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, Utah.

Synovial sarcomas are deadly soft tissue malignancies associated with t(X;18) balanced chromosomal translocations. Expression of the apoptotic regulator BCL2 is prominent in synovial sarcomas and has prompted the hypothesis that synovial sarcomagenesis may depend on it. Herein, it is demonstrated that overexpression enhances synovial sarcomagenesis in an animal model. Read More