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Int J Surg Case Rep 2022 May 31;96:107265. Epub 2022 May 31.

Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province 250025, China. Electronic address:

Prostate synovial sarcoma (SS) is extremely rare. We report a case of prostate SS diagnosed using fine-needle biopsy. The following findings were found: The serum prostate specific antigen level was low, magnetic resonance imaging shows an irregular soft tissue mass in the right posterior part of the prostate, and computed tomography examinations did not reveal any tumor at other parts of the body. Read More

Future Cardiol 2022 Jun 14. Epub 2022 Jun 14.

Clinical Research Development Center, Shahid Modarres Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, 1998734383, Iran.

Primary cardiac synovial sarcoma is a very rare primary cardiac tumor that usually arises in the right side of the heart. Brain metastases in primary cardiac sarcomas are not uncommon. Because of the wild nature of these tumors, they usually have poor outcomes. Read More

Eur J Nucl Med Mol Imaging 2022 Jun 11. Epub 2022 Jun 11.

Department of Nuclear Medicine, The Third Hospital, Hebei Medical University, No. 139, Ziqiang Road, Shijiazhuang, 050051, Hebei, People's Republic of China.

Curr Probl Diagn Radiol 2022 May 2. Epub 2022 May 2.

Department of Radiology, Temple University Health System, 3401 N. Broad St, Philadelphia, PA 19140, United States.

Soft tissue sarcomas are a rare diverse group of mesenchymal malignancies that can arise in any location in the body and have extremely variable presentations. Liposarcoma, pleomorphic undifferentiated sarcoma, leiomyosarcoma, myxofibrosarcoma, and synovial sarcoma constitute 75% of all soft tissue sarcomas. These along with more uncommon sarcomas will be reviewed with emphasis on the 2013 World Health Organization (WHO) classification. Read More

Cureus 2022 Apr 25;14(4):e24457. Epub 2022 Apr 25.

Orthopaedic Surgery, Johns Hopkins University, Baltimore, USA.

Primary intra-articular sarcomas are rare and present with nonspecific symptoms such as pain or swelling. Due to nonspecific symptoms, patients may undergo routine diagnostic arthroscopy, which ultimately leads to sarcoma diagnosis. Here we present four patients with intra-articular sarcomas of the knee diagnosed after arthroscopy. Read More

Iran J Med Sci 2022 May;47(3):280-284

Department of Urology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Synovial Sarcoma (SS) is a rare soft-tissue malignancy. Only about 15% of SS originates from the retroperitoneum. Retroperitoneal SS (RSS) is usually diagnosed incidentally due to the anatomy of the retroperitoneum. Read More

Clin Case Rep 2022 Feb 20;10(2):e05454. Epub 2022 Feb 20.

Hospital Hedi Chaker Pneumology Department of Sfax Sfax Tunisia.

Primary pulmonary synovial sarcoma (SS) is a rare neoplasm. Its clinicoradiologic attributes are not yet well defined. We report the observation of a patient followed for primary pulmonary synovial sarcoma. Read More

J Card Surg 2022 May 7;37(5):1445-1449. Epub 2022 Mar 7.

Division of Cardiac Surgery, University Health Network-Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.

Technical details for complex cardiac tumor resection are sparse. We describe the operative technique of modified autotransplantation for resection of a complex pericardial synovial sarcoma in a 63-year-old, Caucasian female. Surgical exposure demonstrated tumor origin at the superior cavoatrial junction and invasion of the aorta, main pulmonary artery, superior pulmonary veins, and left atrial roof. Read More

Pathol Res Pract 2022 Apr 25;232:153824. Epub 2022 Feb 25.

Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.

Background: Synovial sarcomas (SS) are malignant tumors originating from pluripotent mesenchymal cells, with predilection for periarticular areas, as deep-seated soft tissue tumors. Treatment of SS of the head and neck (HN) is usually radical local excision and additional radiation or (neo)adjuvant chemotherapy or both. SS are characterized by a specific SS18-SSX1/2/4 fusion gene. Read More

World J Clin Cases 2022 Feb;10(5):1623-1629

Department of Orbital Disease and Ocular Tumor, Hebei Eye Hospital, Xingtai 054001, Hebei Province, China.

Background: Synovial sarcoma is a malignant mesenchymal neoplasm with variable epithelial differentiation. Most synovial sarcoma cases are reported in young adults and can arise in any body site. Notably, primary orbital synovial sarcoma is rare. Read More

J Knee Surg 2022 May 21;35(6):597-606. Epub 2022 Feb 21.

The Center for Orthopedic Research and Eduction (CORE) Institute, Phoenix, Arizona.

Intra-articular tumors of the knee are most commonly benign. Overall, this is a relatively rare clinical presentation. The differential diagnosis includes pigmented villonodular synovitis, synovial chondromatosis, lipoma arborescens, synovial hemangioma, and very rarely primary sarcoma (synovial sarcoma being the most common). Read More

Cancers (Basel) 2022 Feb 5;14(3). Epub 2022 Feb 5.

Department of Orthopedic Surgery, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.

Ewing sarcoma is an aggressive and the second most common bone tumor in adolescent and young adult patients. The 5-year survival rate is 60-70% for localized disease but 30% for patients with metastases. Here, we aimed to identify a therapeutic target for Ewing sarcoma and evaluate antibody-based therapeutic agents using in vitro and in vivo models. Read More

Zhonghua Bing Li Xue Za Zhi 2022 Feb;51(2):114-119

Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.

To investigate the immunohistochemical expression of NKX3.1 and NKX2.2 in mesenchymal chondrosarcoma (MC), and to explore the differential diagnostic value of NKX3. Read More

Pediatr Rep 2022 Jan 11;14(1):32-39. Epub 2022 Jan 11.

Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India.

Background: In cases with solid tumors, preoperative radiological investigations provide valuable information on the anatomy of the tumor and the adjoining structures, thus helping in operative planning. However, due to a two-dimensional view in these investigations, a detailed spatial relationship is difficult to decipher. In contrast, three-dimensional (3D) printing technology provides a precise topographic view to perform safe surgical resections of these tumors. Read More

Pan Afr Med J 2021 26;40:187. Epub 2021 Nov 26.

Department of General Surgery, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.

Soft tissue sarcomas are group of malignant tumours arising from extra skeletal mesenchymal tissue. Presenting a patient with swelling over the posterior aspect of left arm for 6 months, gradually increasing in size for four months and rapidly increasing in size for last 2 months and not associated with pain. Peripheral pulses felt. Read More

Diagnostics (Basel) 2022 Jan 10;12(1). Epub 2022 Jan 10.

Department of Radiology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

We report a case of a 52-year-old woman who was referred to our institution with a superior vena cava syndrome and was investigated through echocardiography, CT and MRI revealing a well-defined, encapsulated pericardial mass. The pathology, correlated with the immunohistochemical analysis, concluded it was an extremely rare primary pericardial synovial sarcoma. The patient underwent surgery and chemotherapy with a 16-month disease-free survival and passed away after a contralateral aggressive relapse. Read More

Gan To Kagaku Ryoho 2021 Dec;48(13):2055-2057

Dept. of Surgery, Osaka General Hospital of West Japan Railway Company.

The patient was a 43-year-old man. An upper gastrointestinal endoscopic examination revealed a gastric submucosal tumor(SMT)-like, elevated 8-mm lesion in the greater curvature of the upper body of the stomach. It was diagnosed as spindle cell tumor on the basis of biopsy findings, and a gastrointestinal stromal tumor(GIST)was suspected. Read More

Am J Case Rep 2022 Jan 15;23:e934372. Epub 2022 Jan 15.

Department of Orthopaedic Surgery, Kyushu Rosai Hospital, Kitakyushu, Fukuoka, Japan.

BACKGROUND Clinical management of radiation-associated pathological fracture is challenging because of a high nonunion rate and potential for morbidity. We report a case of radiation-associated insufficiency fracture of the tibial plateau after surgery, perioperative chemotherapy, and adjuvant radiation therapy for synovial sarcoma of the proximal calf that was successfully treated with low-intensity pulsed ultrasound (LIPUS). CASE REPORT A healthy 52-year-old Japanese woman presented with a slowly growing, painful soft tissue mass over her proximal calf. Read More

Ann Diagn Pathol 2022 Apr 10;57:151889. Epub 2022 Jan 10.

Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

Biphenotypic sinonasal sarcoma (BSNS) is a recently described spindle cell sarcoma with neural and myogenic differentiation which arises exclusively in the sinonasal region. A man presented with swelling of left eyelid, and history of resection of a low-grade spindle cell mesenchymal tumor of left sinonasal cavity performed 15 years before. The original diagnosis was synovial sarcoma. Read More

Rom J Morphol Embryol 2021 Apr-Jun;62(2):575-579

3rd Department of Surgery, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece; Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;

Head and neck synovial sarcoma (HNSS) is a rare tumor with a few case reports or case series being published in the literature. We present the case of a 68-year-old patient admitted to our department for management of a palpable neck mass. After initial investigation and due to major problems of differential diagnosis, there was performed a wide excision of the tumor. Read More

Gene 2022 Mar 4;816:146172. Epub 2022 Jan 4.

Department of Oncology and Hematology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Road, Pudong New Area, Shanghai 201318, China. Electronic address:

Objective: Synovial sarcoma (SS) is a malignant soft tissue sarcoma and its natural history is a long, indolent clinical course followed by high rate of local recurrence and distant metastasis. Current therapies are still limited in increasing satisfactory of 5-year survival, especially for patients with recurrence and metastasis. Accordingly, finding new therapeutic drug for SS treatment is clinically urgent need. Read More

Cureus 2021 Dec 1;13(12):e20076. Epub 2021 Dec 1.

Department of Cardiothoracic Surgery, St. John's Medical College Hospital, Bangalore, IND.

Primary mediastinal synovial sarcomas constitute a rare subset of mediastinal tumors. The diagnosis is often delayed at the time of presentation impacting the five-year survival rate due to its highly aggressive natural history. We report a 22-year old female with a monophasic variant of the primary mediastinal synovial sarcoma. Read More

Medicine (Baltimore) 2021 Dec;100(52):e28411

Department of Radiology, Seongnam, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Republic of Korea.

Rationale: Synovial sarcoma is a rare malignant tumor that typically originates from the soft tissue of the extremities. The occurrence of primary pharyngeal synovial sarcoma is even rarer, and few studies have reported its radiological features. Here, we report a case of pediatric primary pharyngeal synovial sarcoma and describe the conventional and advanced magnetic resonance imaging (MRI) findings with pathologic correlation. Read More

Cancer Sci 2022 Feb 21;113(2):721-732. Epub 2021 Dec 21.

Department of Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan.

Synovial sarcomas are rare tumors arising in adolescents and young adults. The prognosis for advanced disease is poor, with an overall survival of 12-18 months. Frizzled homolog 10 (FZD10) is overexpressed in most synovial sarcomas, making it a promising therapeutic target. Read More

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(12):1130-1136

Department of Digestive Surgery, Niigata Cancer Center Hospital.

Primary synovial sarcoma of the spermatic cord is quite rare and has not been reported in Japanese literature. We report a case of primary synovial sarcoma of the spermatic cord and localized dissemination of the tumor in a patient who experienced recurrence of intra-abdominal bleeding 7 years after curative resection of the primary lesion. A 70-year-old man was admitted with disturbance on urination and lower abdominal pain. Read More

Case Rep Oncol Med 2021 28;2021:9945591. Epub 2021 Nov 28.

Faculdade São Leopoldo Mandic, Rua José Rocha Junqueira 13, Swift, 13045-755 Campinas, SP, Brazil.

Synovial sarcoma (SS) is a rare malignant mesenchymal tumor that mainly occurs in body extremities, being uncommon in the head and neck region. In the present study, we described a case of primary intraosseous SS arising in the mandible of a 22-year-old young male. The patient reported a painful swelling on the left side of the mandible for the last 7 months. Read More

BMJ Case Rep 2021 Nov 9;14(11). Epub 2021 Nov 9.

Anatomic Pathology, King Fahad Medical City, Riyadh, Saudi Arabia.

Synovial sarcoma (SS) has a rare occurrence in the female genital tract. Only three prior reports of primary ovarian sarcoma could be retrieved after a thorough literature review. We are reporting a case of primary ovarian SS in a young woman. Read More

World J Clin Cases 2021 Oct;9(29):8871-8878

Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan 750000, Ningxia Hui Autonomous Region, China.

Background: Synovial sarcoma (SS) is a highly malignant tumor of unknown histological origin. This tumor can occur in various parts of the body, including those without synovial structures, but mainly in and around the joints, mostly in the lower extremities. Primary intracranial SSs are remarkably rare. Read More

Cancer Invest 2022 Mar 18;40(3):268-281. Epub 2021 Nov 18.

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Primary sarcomas of the lung represent less than 0.5% of all primary lung tumors and comprise a heterogeneous group of malignancies including synovial sarcoma (SS). Primary pleuropulmonary SS has non-specific presentations, such as chest pain, shortness of breath and cough, and its associated imaging features resemble those of other intrathoracic malignancies. Read More

Curr Treat Options Oncol 2021 10 23;22(12):109. Epub 2021 Oct 23.

IRCCS Azienda Ospedaliero Universitaria di Bologna, via Massarenti 9, 40138, Bologna, Italy.

Opinion Statement: New molecular insights are being achieved in synovial sarcoma (SS) that can provide new potential diagnostic and prognostic markers as well as therapeutic targets. In particular, the advancement of research on epigenomics and gene regulation is promising. The concrete hypothesis that the pathogenesis of SS might mainly depend on the disruption of the balance of the complex interaction between epigenomic regulatory complexes and the consequences on gene expression opens interesting new perspectives. Read More