4,710 results match your criteria Synovial Sarcoma


Distribution and evaluation of bone and soft tissue tumors operated in a tertiary care center.

Acta Orthop Traumatol Turc 2019 Apr 11. Epub 2019 Apr 11.

Department of Orthopaedics and Traumatology, Dr Abdurrahan Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.

Objective: The aim of this study was to retrospectively evaluate the patients who were operated in our orthopedics and traumatology clinic with the suspection of bone and soft tissue tumors.

Methods: A total of 3133 patients (1146 (46.5%) female and 1318 (53. Read More

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http://dx.doi.org/10.1016/j.aott.2019.03.008DOI Listing
April 2019
1 Read

Anlotinib inhibits synovial sarcoma by targeting GINS1: a novel downstream target oncogene in progression of synovial sarcoma.

Clin Transl Oncol 2019 Apr 8. Epub 2019 Apr 8.

Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, No. 600, Yishan Road, Xuhui District, Shanghai, 200233, People's Republic of China.

Background: Synovial sarcoma (SS) is an aggressive soft-tissue sarcoma with a poor prognosis owing to its resistance to radiation and chemotherapy. Thus, novel therapeutic strategies for SS are urgently required. Anlotinib, a new oral tyrosine kinase inhibitor, is designed to primarily inhibit multi-targets in vasculogenesis and angiogenesis. Read More

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http://dx.doi.org/10.1007/s12094-019-02090-2DOI Listing

Establishment and characterization of histologically and molecularly stable soft tissue sarcoma xenograft models for biological studies and preclinical drug testing.

Mol Cancer Ther 2019 Apr 8. Epub 2019 Apr 8.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, KU Leuven.

Soft tissue sarcomas (STS) represent a heterogeneous group of rare, malignant tumors of mesenchymal origin. Reliable in vivo sarcoma research models are scarce. We aimed to establish and characterize histologically and molecularly stable patient-derived xenograft (PDX) models from a broad variety of STS subtypes. Read More

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http://dx.doi.org/10.1158/1535-7163.MCT-18-1045DOI Listing
April 2019
4 Reads

MiR-9 promotes synovial sarcoma cell migration and invasion by directly targeting CDH1.

Int J Biochem Cell Biol 2019 Apr 5. Epub 2019 Apr 5.

Department of Orthopedics, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, PR China. Electronic address:

Background: Invasion and metastasis of synovial sarcoma is the leading cause of death in patients. Epithelial mesenchymal transition (EMT) accelerates tumor cell invasion and metastasis. MiR-9 promotes tumor metastasis by inducing EMT. Read More

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http://dx.doi.org/10.1016/j.biocel.2019.04.001DOI Listing

Expression of NY-ESO-1 and its association with Foxp3 and IDO in microenvironment of non-small cell lung cancer.

HLA 2019 Apr 5. Epub 2019 Apr 5.

Shenzhen Institute for Innovation and Translational Medicine, Shenzhen, Guangdong, China.

Lung cancer is one of the most prevalent and fatal cancer worldwide. The traditional treatment including surgery, radiotherapy, chemotherapy and targeted therapy, are not satisfactory due to severe side effects and/or relapse. Genetically engineered T cell based immunotherapy for malignant cancer shows promise in recent clinical trials. Read More

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http://dx.doi.org/10.1111/tan.13547DOI Listing
April 2019
2 Reads

Computed Tomography-Guided Wire-Marking for Thoracoscopic Resection of Small Lung Nodules in Children.

J Laparoendosc Adv Surg Tech A 2019 Apr 4. Epub 2019 Apr 4.

1 Department of Paediatric Surgery, University Medical Center Erlangen, Friedrich-Alexander-University of Erlangen-Nuremberg (FAU), Erlangen, Germany.

Introduction: In pediatric patients, thoracoscopic wedge-resection of pulmonary nodules is an established therapy. However, intraoperative localization of small lesions is still challenging. Purpose of this study was to evaluate the efficacy of preoperative computed tomography (CT)-guided wire-marking of small lung nodules. Read More

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http://dx.doi.org/10.1089/lap.2018.0184DOI Listing
April 2019
1 Read

Primary giant synovial sarcoma of the right ankle in a woman living with HIV-AIDS: a rare concurrence.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Radiology, University of the West Indies, St Augustine, Trinidad and Tobago.

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http://dx.doi.org/10.1136/bcr-2018-228958DOI Listing
March 2019
1 Read

Very long-term survivors among patients with metastatic soft tissue sarcoma.

Cancer Med 2019 Mar 27. Epub 2019 Mar 27.

Department of Medical Oncology, Centre Léon Bérard, Lyon, France.

Background: Metastatic soft tissue sarcomas (STS) are a group of rare and heterogeneous mesenchymal tumors with a poor prognosis. The aim of this study was to evaluate the incidence of long-term survivors and describe their presentation and management in a large cohort of patients with metastatic STS.

Methods: We collected information of patients with metastatic STS managed in Centre Leon Berard between 1985 and 2015 aiming to compare the group of patients alive 5 years after the diagnosis of metastases vs the others. Read More

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http://dx.doi.org/10.1002/cam4.1931DOI Listing

Epigenetic Changes at the Promoter Induced by YM155 in Synovial Sarcoma.

J Clin Med 2019 Mar 24;8(3). Epub 2019 Mar 24.

Departments of Orthopedics and Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.

YM155 is an anti-cancer therapy that has advanced into 11 different human clinical trials to treat various cancers. This apoptosis-inducing therapy indirectly affects the protein levels of survivin (gene: ), but the molecular underpinnings of the mechanism remain largely unknown. Synovial sarcoma is a rare soft-tissue malignancy with high protein expression of survivin. Read More

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http://dx.doi.org/10.3390/jcm8030408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463023PMC
March 2019
1 Read

Overactive IGF1/Insulin Receptors and NRASQ61R Mutation Drive Mechanisms of Resistance to Pazopanib and Define Rational Combination Strategies to Treat Synovial Sarcoma.

Cancers (Basel) 2019 Mar 22;11(3). Epub 2019 Mar 22.

Department of Applied Research and Technological Development, Molecular Pharmacology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo 42, 20133 Milan, Italy.

Pazopanib is approved for treatment of advanced soft tissue sarcomas, but primary and secondary drug resistance limits its clinical utility. We investigated the molecular mechanisms mediating pazopanib resistance in human synovial sarcoma (SS) models. We found reduced cell sensitivity to pazopanib associated with inefficient inhibition of the two critical signaling nodes, AKT and ERKs, despite strong inhibition of the main drug target, PDGFRα. Read More

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http://dx.doi.org/10.3390/cancers11030408DOI Listing

The role of 18F-FDG PET/CT in soft tissue sarcoma.

Nucl Med Commun 2019 Mar 22. Epub 2019 Mar 22.

IRCCS Rizzoli Orthopaedic Institute.

Introduction: Soft tissue sarcomas (STS) are highly fluorine-18-fluorodeoxyglucose (F-FDG)-avid tumours. PET seems to be effective for the assessment of the extent of disease. However, the use of PET to stratify STS into different risk histotypes still remains controversial. Read More

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http://Insights.ovid.com/crossref?an=00006231-900000000-9841
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http://dx.doi.org/10.1097/MNM.0000000000001002DOI Listing
March 2019
3 Reads

Small soft tissue masses indeterminate at imaging: histological diagnoses at a tertiary orthopedic oncology clinic.

Skeletal Radiol 2019 Mar 22. Epub 2019 Mar 22.

Department of Radiology, University of Miami Miller School of Medicine/Jackson Memorial Hospital, 1611 NW 12th Ave, JMH WW 279, Miami, FL, 33136, USA.

Objective: To review histologic diagnoses of soft-tissue masses (STMs) ≤ 2 cm with indeterminate imaging features encountered in musculoskeletal oncology clinic at a tertiary referral center.

Materials And Methods: This was an IRB-approved retrospective review of patients with STMs ≤ 2 cm, referred to our tertiary care orthopedic oncology clinic over 4.75 consecutive years. Read More

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http://link.springer.com/10.1007/s00256-019-03205-0
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http://dx.doi.org/10.1007/s00256-019-03205-0DOI Listing
March 2019
7 Reads

Neutrophilic eccrine hidradenitis secondary to pegfilgrastim in a patient with synovial sarcoma.

Clin Case Rep 2019 Mar 7;7(3):533-536. Epub 2019 Feb 7.

University of Kansas Hospital Kansas City Kansas.

Here, we report a case of neutrophilic eccrine hidradenitis (NEH) in a teenage male with synovial sarcoma associated with extracutaneous manifestations including myositis and splenomegaly secondary to pegfilgrastim. To the best of our knowledge, NEH has not been previously reported to occur in association with extracutaneous manifestations. Read More

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http://dx.doi.org/10.1002/ccr3.1932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406152PMC
March 2019
2 Reads

The BAF complex in development and disease.

Epigenetics Chromatin 2019 03 21;12(1):19. Epub 2019 Mar 21.

Department of Paediatric Haematology and Oncology, University Children's Hospital Muenster, Domagkstraße 24, 48149, Muenster, Germany.

The ATP-dependent chromatin remodelling complex BAF (= mammalian SWI/SNF complex) is crucial for the regulation of gene expression and differentiation. In the course of evolution from yeast to mammals, the BAF complex evolved an immense complexity with a high number of subunits encoded by gene families. In this way, tissue-specific BAF function and regulation of development begin with the combinatorial assembly of distinct BAF complexes such as esBAF, npBAF and nBAF. Read More

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https://epigeneticsandchromatin.biomedcentral.com/articles/1
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http://dx.doi.org/10.1186/s13072-019-0264-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427853PMC
March 2019
3 Reads

Surgical management of primary malignant proximal fibular tumors: Functional and clinical outcomes of 23 patients.

Eklem Hastalik Cerrahisi 2019 Apr;30(1):24-31

Department of Orthopedics and Traumatology, University of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, 06200, Demetevler, Ankara, Turkey.

Objectives: This study aims to evaluate the clinical characteristics and treatment outcomes of patients with primary malignant tumors located in the proximal fibula.

Patients And Methods: This retrospective study included 23 patients (15 males, 8 females; mean age 22.1 years; range, 9 to 63 years) with primary malignant tumors located in the proximal fibula between May 2007 and May 2017. Read More

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http://dx.doi.org/10.5606/ehc.2019.62888DOI Listing
April 2019
1 Read

Immunohistochemical expression and clinicopathological assessment of the cancer testis antigens NY-ESO-1 and MAGE-A4 in high-grade soft-tissue sarcoma.

Oncol Lett 2019 Apr 14;17(4):3937-3943. Epub 2019 Feb 14.

Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Mie 514-8507, Japan.

The aim of the present study was to explore the expression of the cancer testis antigens New York-esophageal squamous cell carcinoma (NY-ESO)-1 and melanoma-associated antigen (MAGE)-A4 in high-grade soft-tissue sarcoma and to evaluate their association with the standard clinical-pathological features of surgically treated high-grade sarcoma patients. The study included 82 patients, and NY-ESO-1 and MAGE-A4 antigen expression was analyzed immunohistochemically. The results revealed NY-ESO-1- and MAGE-A4-positive staining in 58. Read More

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http://dx.doi.org/10.3892/ol.2019.10044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403520PMC
April 2019
1 Read

Interactions between cadherin-11 and platelet-derived growth factor receptor-alpha signaling link cell adhesion and proliferation.

Biochim Biophys Acta Mol Basis Dis 2019 Mar 13. Epub 2019 Mar 13.

Division of Rheumatology, Department of Medicine, University of Washington, 750 Republican St, Seattle, WA 98019, USA; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA. Electronic address:

Cadherins are homophilic cell-to-cell adhesion molecules that help cells respond to environmental changes. Newly formed cadherin junctions are associated with increased cell phosphorylation, but the pathways driving this signaling response are largely unknown. Since cadherins have no intrinsic signaling activity, this phosphorylation must occur through interactions with other signaling molecules. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.03.001DOI Listing
March 2019
1 Read

Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma.

Diagn Pathol 2019 Mar 14;14(1):24. Epub 2019 Mar 14.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.

A recent study on 15 patients with synovial sarcoma demonstrated very low prevalence of tumor-specific fusion transcripts in peripheral blood specimens. Our results in an independent cohort of 38 patients with synovial sarcoma support these findings. Synovial sarcoma patients could greatly benefit from a non-invasive monitoring of tumor burden by liquid biopsies. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-019-0800-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419438PMC
March 2019
6 Reads

Standard treatment and emerging drugs for managing synovial sarcoma: adult's and pediatric oncologist perspective.

Expert Opin Emerg Drugs 2019 03;24(1):43-53

d Pediatric Oncology Unit , Fondazione IRCCS Istituto Nazionale dei Tumori , Milan , Italy.

Introduction: in this review we discuss the standard of care for both pediatric and adult synovial sarcoma (SS), the prognostic differences between them, and the treatments available for localized and advanced diseases. We also overview the biology and the recent drugs under consideration in clinical trials on SS. Areas covered: we focus on new targeted therapies being investigated for advanced SS, especially anti-angiogenic drugs, and immunotherapy. Read More

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http://dx.doi.org/10.1080/14728214.2019.1591367DOI Listing
March 2019
1 Read
3.058 Impact Factor

SS18-SSX-dependent YAP/TAZ Signaling in Synovial Sarcoma.

Clin Cancer Res 2019 Feb 27. Epub 2019 Feb 27.

Division of Translational Pathology, Gerhard-Domagk-Institute of Pathology, University Hospital Muenster

Synovial sarcoma is a soft tissue malignancy characterized by a reciprocal t(X;18) translocation. The chimeric SS18-SSX fusion protein acts as a transcriptional dysregulator representing the major driver of the disease; however, the signaling pathways activated by SS18-SSX remain to be elucidated in order to define innovative therapeutic strategies. Immunohistochemical evaluation of the Hippo signaling pathway effectors YAP/TAZ was performed in a large cohort of synovial sarcoma tissue specimens. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3553DOI Listing
February 2019
3 Reads

Primary Renal Synovial Sarcomas: PAX 8 Immunostaining and Unusual Molecular Findings.

Appl Immunohistochem Mol Morphol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

Synovial sarcoma (SS) is a high-grade sarcoma that rarely involves the kidney. Eleven renal SS cases were collected in our institution. Immunostaining features and molecular changes of renal SS were further elucidated in this study. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000736DOI Listing
February 2019
2 Reads

Localized synovial sarcoma: A single institutional study of 191 patients with a minimum follow-up of 5 years for survivors.

J Surg Oncol 2019 Feb 20. Epub 2019 Feb 20.

Oncology Service, Royal Orthopaedic Hospital, Birmingham, United Kingdom.

Purpose: Factors affecting long-term outcomes of synovial sarcoma (SS) remain unknown. Here, we aimed to investigate the long-term oncological outcomes and prognostic factors in a large group of patients with surgically-treated localized SS.

Patients And Methods: Between 1980 and 2011, 191 patients (94 males and 97 females) were treated at a single hospital with a minimum follow-up of 5 years for survivors. Read More

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http://dx.doi.org/10.1002/jso.25417DOI Listing
February 2019

Machine learning analysis of gene expression data reveals novel diagnostic and prognostic biomarkers and identifies therapeutic targets for soft tissue sarcomas.

PLoS Comput Biol 2019 02 20;15(2):e1006826. Epub 2019 Feb 20.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Based on morphology it is often challenging to distinguish between the many different soft tissue sarcoma subtypes. Moreover, outcome of disease is highly variable even between patients with the same disease. Machine learning on transcriptome sequencing data could be a valuable new tool to understand differences between and within entities. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398862PMC
February 2019
1 Read

Concurrent Papillary Thyroid Carcinoma and Synovial Carcinoma of the Neck in an Adult Male.

Iran J Otorhinolaryngol 2019 Jan;31(102):69-72

Department of Pathology, Aga Khan University hospital, Karachi, Pakistan.

Introduction: Synovial sarcoma makes up 8-10% of all soft tissue sarcomas, and constitutes 3-10% of all sarcomas occurring in the head and neck region. It shows male predominance (3:2), and the mean age of presentation is 30 years.

Case Report: A 51-year-old gentleman presented with right-sided neck swelling which had been progressively increasing in size for the past 2 years. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368986PMC
January 2019
1 Read

Genotyping of circulating cell-free DNA enables noninvasive tumor detection in myxoid liposarcomas.

Int J Cancer 2019 Feb 18. Epub 2019 Feb 18.

Department of Plastic and Hand Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Soft tissue sarcomas (STS) are rare tumors of mesenchymal origin. About 50% of patients with STS experience relapse and more than 30% will die within 10 years after diagnosis. In this study we investigated circulating free DNA (cfDNA) and tumor-specific genetic alterations therein (circulating tumor DNA, ctDNA) as diagnostic biomarkers. Read More

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http://dx.doi.org/10.1002/ijc.32216DOI Listing
February 2019
1 Read

Acute Postoperative Pain Management After Major Limb Amputation in a Pediatric Patient: A Case Report.

J Perianesth Nurs 2019 Feb 8. Epub 2019 Feb 8.

Purpose: Although total prevention of phantom pain is difficult, pediatric patients requiring amputation benefit from an individualized combination of analgesic techniques for phantom pain reduction using a multimodal and interprofessional approach. This is especially useful in the event a single therapy is ineffective for total pain reduction, and may ultimately lead to a reduction in chronic pain development.

Design: Case report with multimodal and interprofessional approach. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10899472183040
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http://dx.doi.org/10.1016/j.jopan.2018.11.004DOI Listing
February 2019
1 Read

Primary cardiac synovial sarcoma that was continuous with the mitral valve caused severe thrombocytopenia: a case report.

J Cardiothorac Surg 2019 Feb 4;14(1):30. Epub 2019 Feb 4.

Cardiac Surgery Department, Peking University People's Hospital, Beijing, 100044, China.

Background: Primary cardiac sarcomas are exceedingly rare, and they commonly result in nonspecific constitutional symptoms such as shortness of breath, weight loss, and anaemia-related fatigue and malaise. However, thrombocytopenia has very rarely been reported in association with cardiac tumours, either benign or malignant. We report one case of primary cardiac synovial sarcoma continuous with the mitral valve, which was accompanied by severe thrombocytopenia, and the platelet counts returned rapidly to a normal range early after tumour excision and without any special therapies. Read More

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http://dx.doi.org/10.1186/s13019-019-0852-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360734PMC
February 2019
17 Reads

Intraosseous synovial sarcoma of the distal ulna: a case report and review of the literature.

BMC Cancer 2019 Feb 1;19(1):116. Epub 2019 Feb 1.

Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.

Background: Synovial sarcoma is a relatively rare type of soft tissue sarcoma. The commonly observed symptom is a deep-seated palpable mass accompanied by pain or tenderness. Thus, it is considered a soft tissue sarcoma and rarely occurs primarily in bone. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5325-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359868PMC
February 2019
7 Reads

Management of primary retroperitoneal synovial sarcoma: A case report and review of literature.

World J Gastrointest Surg 2019 Jan;11(1):27-33

4 Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, Chaidari, Athens 12462, Greece.

Background: Synovial sarcoma (SS) is a rare type of soft tissue sarcoma that is usually developed from areas where synovial tissue exists, especially at the extremities. Nevertheless, several cases of retroperitoneal SS (RSS) have been described. We herein report a case of RSS presented in our institution. Read More

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http://dx.doi.org/10.4240/wjgs.v11.i1.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354068PMC
January 2019
3 Reads

Synovial sarcoma in an HIV-positive pregnant woman and review of literature.

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Hertfordshire HIV Service, Chelsea and Westminster Hospital, London, UK.

We present a first case of synovial sarcoma in an HIV-positive pregnant woman. This 28-year-old woman was diagnosed with synovial sarcoma, a high-grade malignant soft tissue sarcoma, involving her left thigh during the first trimester of her pregnancy. She underwent surgical treatment in the form of hip disarticulation at 30 weeks' gestation. Read More

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http://dx.doi.org/10.1136/bcr-2018-227646DOI Listing
January 2019
3 Reads

Histomorphological and Immunohistochemical Analysis of Pleural Neoplasms.

Iran J Pathol 2018 17;13(2):196-204. Epub 2018 Jul 17.

Registrar Pathology, Apollo Hospitals, Bangalore, Bangalore, India.

Background & Objective: Primary pleural neoplasms are rare entities compared with the pleural involvement by metastatic carcinoma.The current study aimed at investigating the complete spectrum of pleural neoplasms and differentiating between them with the aid of immunohistochemistry (IHC).

Methods: Consecutive pleural biopsy specimens positive for a neoplasm, both primary and metastatic, were included in the study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339503PMC
July 2018
2 Reads

Poorly differentiated pulmonary synovial sarcoma with SYT gene amplification: A case report.

Mol Clin Oncol 2019 Feb 7;10(2):249-252. Epub 2018 Dec 7.

Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China.

Fluorescence hybridization (FISH) and reverse-transcription polymerase chain reaction (RT-PCR) analysis may be used for the diagnosis of synovial sarcoma (SS), particularly of the poorly differentiated type. While the majority of the studies report that the SYT FISH probe is considered to be break-apart in SS, with two orange and two green signals, the SYT probe in the present case of a 52-year-old male patient with pulmonary SS displayed orange and green signal separation, along with SYT orange signal amplification. RT-PCR was used to verify that the SYT gene amplification was another form of expression of SYT-SSX gene fusion t(X; 18)(p11; q11). Read More

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http://dx.doi.org/10.3892/mco.2018.1787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327209PMC
February 2019
1 Read

Proteomic signatures corresponding to the SS18/SSX fusion gene in synovial sarcoma.

Oncotarget 2018 Dec 25;9(101):37509-37519. Epub 2018 Dec 25.

Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.

Synovial sarcoma (SS) is a malignant soft tissue lesion and most commonly arises in young adults. Chromosomal translocation t(X;18)(p11;q11) results in the formation of / by gene fusion of the SS18 gene on chromosome 18 to either , , or gene located on chromosome X, which is detected in more than 95% of SSs. Although multiple lines of evidence suggest that the fusion is the oncogene in this tumor, the protein expression profiles associated with / have yet to be elucidated. Read More

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http://dx.doi.org/10.18632/oncotarget.26493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331019PMC
December 2018

STAT6 Expression in Solitary Fibrous Tumor and Histologic Mimics: a Single Institution Experience.

Appl Immunohistochem Mol Morphol 2019 Jan 19. Epub 2019 Jan 19.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

STAT6 stain has proved to be a good surrogate marker for the genetic alteration (NAB2-STAT6 gene fusion) in solitary fibrous tumor (SFT). This study aims to validate the use of STAT6 rabbit monoclonal antibody in differentiating SFT from its histologic mimics. Forty-five cases of SFT and 110 cases from 9 other spindle cell tumors were collected for STAT6 immunostaining. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000745DOI Listing
January 2019
5 Reads

Monophasic synovial sarcoma as a cause of obstructive ileus: A case report.

Mol Clin Oncol 2019 Jan 16;10(1):185-187. Epub 2018 Nov 16.

Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, 11528 Athens, Greece.

Synovial sarcoma is a high-grade soft tissue sarcoma, divided histologically into 3 types: Monophasic, biphasic and poorly differentiated. An extremely rare case of obstructive ileus due to monophasic synovial sarcoma in a 54-year-old male patient is reported in the present study. The patient presented to the emergency department with signs and symptoms of obstructive ileus. Read More

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http://www.spandidos-publications.com/10.3892/mco.2018.1768
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http://dx.doi.org/10.3892/mco.2018.1768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313936PMC
January 2019
17 Reads

New fusion sarcomas: histopathology and clinical significance of selected entities.

Hum Pathol 2019 Apr 8;86:57-65. Epub 2019 Jan 8.

Laboratory of Pathology, National Cancer Institute, Bethesda 20892, MD.

Many sarcomas contain gene fusions that can be pathogenetic mechanisms and diagnostic markers. In this article we review selected fusion sarcomas and techniques for their detection. CIC-DUX4 fusion sarcoma is a round cell tumor now considered an entity separate from Ewing sarcoma with a more aggressive clinical course, occurrence in older age, and predilection to soft tissues. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.006DOI Listing
April 2019
17 Reads

Pediatric Tonsillar Synovial Sarcoma- Very Rare Localization: A Case Report and Review of the Literature.

Turk Patoloji Derg 2019 Jan 11. Epub 2019 Jan 11.

Department of Pediatric Hematology and Oncology, Akdeniz University Medicine Faculty, ANTALYA, TURKEY.

Tonsillar synovial sarcoma is an extremely rare entity and only 9 adult patients have been reported up to now. Here, we describe the first pediatric tonsillar synovial sarcoma of the literature in a patient who presented with a 2-month history of dysphagia and snoring. Clinical and radiological examinations showed that the tumor arose from the right palatine tonsil and narrowed the parapharyngeal space. Read More

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http://www.turkjpath.org/doi.php?doi=10.5146/tjpath.2018.014
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http://dx.doi.org/10.5146/tjpath.2018.01449DOI Listing
January 2019
10 Reads

Analysis of mutations in primary and metastatic synovial sarcoma.

Oncotarget 2018 Dec 7;9(96):36878-36888. Epub 2018 Dec 7.

The Children's Guild Foundation Down Syndrome Research Program, Genetics and Genomics Program, Department of Cancer Genetics and Genomics, Roswell Park Cancer Institute, Buffalo, NY, USA.

Synovial sarcoma is the most common pediatric non-rhabdomyosarcoma soft tissue sarcoma and accounts for about 8-10% of all soft tissue sarcoma in childhood and adolescence. The presence of a chromosomal translocation-associated -fusion gene is causally linked to development of primary synovial sarcoma. Metastases occur in approximately 50-70% of synovial sarcoma cases with yet unknown mechanisms, which led to about 70-80% mortality rate in five years. Read More

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http://www.oncotarget.com/fulltext/26416
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http://dx.doi.org/10.18632/oncotarget.26416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305143PMC
December 2018
12 Reads

Primary Synovial Sarcoma of the Mediastinum with Long-term Follow-up.

Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Department of Pulmonary Medicine, Thoracic Center, St. Luke's International Hospital, Japan.

Chest radiography showed a right posterior mass on the mediastinum of an 84-year-old woman. The mass had been growing gradually for four years. Surgical excision was performed, and a pathological examination found the mass to be consistent with primary synovial sarcoma (SS) of the mediastinum. Read More

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http://dx.doi.org/10.2169/internalmedicine.2199-18DOI Listing
January 2019
4 Reads

Primary Orbital Synovial Sarcoma Mimicking a Periocular Cyst.

Am J Dermatopathol 2019 Jan 3. Epub 2019 Jan 3.

Unit of Ocular Oncology, Department of Surgery and Translational Medicine, Careggi University Hospital, Florence, Italy.

Synovial sarcoma (SS) is a high-grade soft-tissue sarcoma occurring predominantly in older children and young adults. Only approximately 7% occur in the head and neck region, with SS representing less than 0.1% of all head and neck cancers. Read More

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http://Insights.ovid.com/crossref?an=00000372-900000000-9822
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http://dx.doi.org/10.1097/DAD.0000000000001351DOI Listing
January 2019
3 Reads

Sports activity after soft tissue sarcoma of the lower extremity.

Disabil Rehabil 2019 Jan 8:1-6. Epub 2019 Jan 8.

a Department of Orthopaedic Surgery , Medical University of Vienna, Vienna General Hospital , Vienna , Austria.

Introduction: The aim of this case series was to assess sports activity levels in long-term survivors of soft-tissue sarcomas after multimodal treatment including limb salvaging surgical resection and radio-chemotherapy.

Methods: Thirty-two patients (17 f/15 m) with a mean age of 29 (range 10-44) years at the time of diagnosis and a mean follow-up time of 9 (range 3-21) years following sarcoma were included. Ten patients had been diagnosed with liposarcoma, seven with synovial sarcoma, four with fibrosarcoma, three with undifferentiated pleomorphic sarcomas and the remaining eight patients with different soft-tissue sarcoma entities. Read More

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https://www.tandfonline.com/doi/full/10.1080/09638288.2018.1
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http://dx.doi.org/10.1080/09638288.2018.1520929DOI Listing
January 2019
17 Reads

Gouty Tophi in Sinus Tarsi of Bilateral Feet Mimicking Synovial Sarcoma:A Case Report.

J Foot Ankle Surg 2019 Mar 3;58(2):347-351. Epub 2019 Jan 3.

Director, Podiatric Surgical Residency, Beaumont Hospital Wayne, Wayne, MI.

Chronic gout is defined as accumulation of monosodium urate crystals in joints, cartilage, tendons, bursae, bone, and soft tissue. The foot is the most common location for acute gout flares, with the first metatarsophalangeal joint being the most frequent site of tophus formation. However, few studies have reported gouty tophus formation in the subtalar joint. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.08.031DOI Listing
March 2019
2 Reads

Distal extremities soft tissue sarcomas: Are they so different from other limb localizations?

J Surg Oncol 2019 Mar 4;119(4):479-488. Epub 2019 Jan 4.

Faculté de Médecine de la Timone, Génétique Médicale et génomique fonctionnelle, UMR S910 Inserm, Université Aix-Marseille 2, Marseille, France.

Background And Objectives: Soft tissue sarcoma localization in distal extremities (DESTS) of the limbs (hand/fingers, and foot/toes) is unusual. The literature is scarce about their behavior and this study was designed to assess their epidemiological characteristics, outcomes, and prognosis compared to other limb localizations (OLSTS).

Methods: From 1980 to 2010, adult DESTS and OLSTS in 22 centers were included. Read More

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http://dx.doi.org/10.1002/jso.25359DOI Listing
March 2019
2 Reads

Frequent TLE1 Expression in Cutaneous Neoplasms.

Am J Dermatopathol 2019 Jan;41(1):1-6

Dermatopathologist, Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.

TLE1 immunohistochemistry is widely used as a biomarker for synovial sarcoma. Recently, we identified TLE1 expression in a subset of melanomas and noted staining in sebaceous glands and follicular epithelium. TLE1 immunohistochemistry has not been well studied in cutaneous tumors. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001186DOI Listing
January 2019
3 Reads

FDG PET/CT Findings of a Synovial Sarcoma in a Renal Transplant.

Clin Nucl Med 2019 Mar;44(3):259-261

From the Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, China.

A 48-year old man who underwent renal transplantation 2 years ago due to chronic renal failure underwent FDG PET/CT to determine the etiology of multiple lesions in the renal transplant incidentally found on routine examination. The images demonstrated several foci of the abnormally increased activity in the transplanted kidney with SUVmax of 7.5. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002429DOI Listing
March 2019
2 Reads
3.931 Impact Factor

An update of molecular pathology of bone tumors. Lessons learned from investigating samples by next generation sequencing.

Genes Chromosomes Cancer 2019 02 24;58(2):88-99. Epub 2018 Dec 24.

Department of Pathology, The Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom.

The last decade has seen the majority of primary bone tumor subtypes become defined by molecular genetic alteration. Examples include giant cell tumour of bone (H3F3A p.G34W), chondroblastoma (H3F3B p. Read More

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http://doi.wiley.com/10.1002/gcc.22699
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http://dx.doi.org/10.1002/gcc.22699DOI Listing
February 2019
8 Reads

A Rare Case of Monophasic Synovial Sarcoma of Thoracic Vertebra.

Case Rep Med 2018 18;2018:2313927. Epub 2018 Nov 18.

Raritan Bay Medical Center, Perth Amboy, NJ, USA.

Synovial sarcoma of spine is an extremely rare malignancy with poor prognosis. It is often metastatic at the time of presentation. Its relative rarity and histological resemblance to other tumors make it diagnostically challenging, requiring the need of immunohistochemistry and cytogenetics for definite diagnosis. Read More

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http://dx.doi.org/10.1155/2018/2313927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276405PMC
November 2018
1 Read