46,365 results match your criteria Synovial Sarcoma


Suppressive Effects of the Standardized Extract of Phyllanthus amarus on Type II collagen-induced Rheumatoid Arthritis in Sprague Dawley Rats.

Curr Pharm Biotechnol 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Medicine,University of Tabuk, Tabuk 71491. Saudi Arabia.

Background: Standardized extract of Phyllanthus amarus has been shown to possess inhibitory effects on cellular and humoral immune responses in Wistar-Kyoto rats and Balb/c mice.

Objective: In the present study, the standardized extract of P. amarus was investigated for its suppressive effects on type II collagen-induced rheumatoid arthritis (TCIA) in Sprague Dawley rats. Read More

View Article
December 2018

The effects of radiosynoviorthesis in pigmented villonodular synovitis of the knee.

Arch Orthop Trauma Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.

Introduction: Tenosynovial giant-cell tumor also known as pigmented villonodular synovitis (PVS) is a benign but aggressive synovial proliferative disease most often affecting the knee joint. The mainstay of therapy is surgical resection. Due to a high rate of local recurrence, radiosynoviorthesis (RSO) is used as an adjuvant method in many cases. Read More

View Article
December 2018

Evaluation of transforming growth factor beta 1 in dogs with osteoarthritis.

Open Vet J 2018 25;8(4):386-392. Epub 2018 Oct 25.

Institute of Veterinary Medicine, Georg-August University Göttingen, Burckhardtweg 2, D-37077 Göttingen, Germany.

Osteoarthritis is a common problem in daily veterinary practice with insufficient knowledge about disease mechanism. Because fibrosis is a part of the alteration in the effected joints, we investigated the transforming growth factor beta 1 (TGF-β1) as an important regulation molecule of tissue fibrosis. We chose Osteoarthritis following a cruciate ligament rupture (CLR) because it is a common model of osteoarthritis. Read More

View Article
October 2018

A Case of Primary Intra-abdominal Synovial Sarcoma.

Indian J Surg Oncol 2018 Dec 22;9(4):636-639. Epub 2018 May 22.

2Department of General and Gastrointestinal Surgery, Medical Trust Hospital, M.G. Road, Kochi, Kerala 682016 India.

Synovial sarcomas are relatively common intermediate-to-high-grade malignant soft tissue tumors, often with an initial indolent course. And among the sarcomas primary intra-abdominal synovial sarcoma is a relatively rare entity that may present with an abdominal mass and diagnosis is usually confirmed by immunohistochemistry. The authors report a case of a 46-year-old man who presented with a large palpable abdominal mass. Read More

View Article
December 2018

Collagen II-primed Foxp3 Transduced T Cells Ameliorate Collagen-induced Arthritis in Rats: The Effect of Antigenic Priming on T Regulatory Cell Function.

Iran J Allergy Asthma Immunol 2018 Aug 12;17(4):361-371. Epub 2018 Aug 12.

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AND Molecular Immunology Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Regulatory T cells (Tregs) play a major role in the prevention of autoimmune diseases. Transfer of Foxp3 gene into conventional T cells converts their phenotype to regulatory T cells. Therefore, the question arises as to whether adoptively transferred in vitro differentiated Treg cells specific for a locally expressed antigen might have better inhibitory effects on the progression of the disease as compared with antigen-nonspecific T reg cells. Read More

View Article

Musculoskeletal Ultrasound in Early Rheumatoid Arthritis - Correlations with Disease Activity Score.

Curr Health Sci J 2015 Jul-Sep;41(3):213-218. Epub 2015 Jan 29.

University of Medicine and Pharmacy of Craiova, Rheumatology Department.

Purpose: to assess synovial inflammation using musculoskeletal ultrasonography, in a cohort of patients with early rheumatoid arthritis, and establish the correlations with disease activity score.

Material And Methods: We enrolled 29 patients diagnosed with early RA, according to ACR-EULAR 2010 classification criteria, in Rheumatology Clinic, Emergency County Hospital Craiova, between September 2013-August 2014. We performed clinical evaluation, assessed laboratory tests and performed US for all the patients. Read More

View Article
January 2015

Persistence of fluorescent nanoparticle-labeled bone marrow mesenchymal stem cells in vitro and after intra-articular injection.

J Tissue Eng Regen Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.

Mesenchymal stem cells (MSCs) improve the osteoarthritis condition, but the fate of MSCs after intra-articular injection is unclear. We used fluorescent nanoparticles (quantum dots; QDs) to track equine MSCs (QD-MSCs) in vivo after intra-articular injection to normal and osteoarthritic joints. One week after injection of QD-MSCs, unlabeled MSCs, or vehicle we determined the presence of QD-MSCs in synovium and articular cartilage histologically. Read More

View Article
December 2018

The role of increased synovial fluid A disintegrin and metalloproteinase with thrombospondin motifs4 and serglycin levels in osteoarthritis.

Authors:
Kenan Özler

Ir J Med Sci 2018 Dec 7. Epub 2018 Dec 7.

Konya Beysehir State Hospital, Beyşehir Devlet Hastanesi, 042100, Konya, Turkey.

Background: The first research to determine synovial fluid ADAMTS4 and serglycin levels in osteoarthritis and OA progression.

Aim: We aimed to determine ADAMTS4 and serglycin levels, interactions, and changes in the synovial fluid of knee OA, and also to determine effective in OA progression.

Methods: A case-control study was carried out including a total of 88 participants (29 patients late OA [LOA], 28 early OA [EOA], and 30 controls). Read More

View Article
December 2018

Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes.

Int J Mol Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, P.R. China.

The present study investigated the mechanisms of apoptosis induced by cryptotanshinone (CT) in human rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLSs). Cell Counting kit‑8 assay was performed to determine the cytotoxic effects of CT in human RA‑FLSs, including primary RA‑FLS, HFLS‑RA and MH7A cells, and in HFLS cells derived from normal synovial tissue. Annexin V‑FITC/PI staining was used to detect the apoptotic effects of CT in HFLS‑RA and MH7A cells. Read More

View Article
December 2018

Multimodal ultrasonographic evaluation in a case with unossified primary synovial osteochondromatosis.

Med Ultrason 2018 Dec;20(4):527-530

2nd Internal Medicine Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Primary synovial osteochondromatosis is a rare disorder and its diagnosis remains a challenge to the physician. We present the case of 36 year old patient with right knee monoarthritis in which ultrasound findings, corroborated with clinical and histopathological evidence confirmed the diagnosis of unossified primary synovial osteochondromatosis. The arthroscopy with synovectomy found multiple intra-articular loose bodies occupying the entire joint. Read More

View Article
December 2018

Musculoskeletal ultrasound as a biomarker of remission - results from a one-year prospective study in patients with rheumatoid arthritis.

Med Ultrason 2018 Dec;20(4):453-460

Medical University of Plovdiv, Medical Faculty, Department of Propedeutic of Internal Diseases; University Hospital "Kaspela'', Rheumatology Clinic.

Aims: To assess the role of musculoskeletal ultrasound (MSUS) as a biomarker of remission and to compare the rates of clinical and imaging remission in patients with rheumatoid arthritis (RA) on different types of treatment.

Material And Methods: One hundred and forty-one patients underwent physical and ultrasound examination at 5 visits (at baseline and after 1, 3, 6 and 12 months). Patients were divided into two groups according to the type of treatment, which involved synthetic (sDMARDs) and biologic (bDMARDs) disease-modifying antirheumatic drugs. Read More

View Article
December 2018
1 Read

Arthroscopic Treatment of Popliteal Cysts.

Arthrosc Tech 2018 Nov 8;7(11):e1109-e1114. Epub 2018 Oct 8.

Division of Sports Medicine, Michigan State University, East Lansing, Michigan, U.S.A.

Popliteal cysts, often referred to as Baker's cysts, are a common occurrence in the adult knee. Although controversy exists as to the exact indications for treatment, these structures can cause extreme discomfort and morbidity, including pain from rupture and symptoms from neurovascular compromise. Prior to the development of the arthroscope, open treatment of popliteal cysts was not uncommon. Read More

View Article
November 2018

Accuracy of Synovial Leukocyte and Polymorphonuclear Cell Count in Patients with Shoulder Prosthetic Joint Infection.

J Bone Jt Infect 2018 11;3(5):245-248. Epub 2018 Nov 11.

Department of Orthopaedics and Traumatology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

Joint aspiration in suspected infected implants is a validated diagnostic method in establishing the diagnosis of prosthetic joint infection (PJI). Cut-off values for synovial leukocyte counts and differentials are well described for patients with hip and knee PJI. In 19 failed shoulder implants, a leucocyte count of >12. Read More

View Article
November 2018

Serum starvation raises turnover of phosphorylated p62/SQSTM1 (Serine 349), reveals expression of proteasome and N-glycanase1 interactive protein RAD23B and sensitizes human synovial fibroblasts to BAY 11-7085-induced cell death.

Oncotarget 2018 Nov 9;9(88):35830-35843. Epub 2018 Nov 9.

Department of Rheumatology, GIGA Research, University Hospital Sart-Tilman, Liege, Belgium.

Phosphorylation of p62/SQSTM1 (p62) on Serine 349 (P-Ser349 p62) as well as proteasome dysfunction have been shown to activate the cell protective Keap1/Nrf2 pathway. We showed previously that BAY 11-7085-induced human synovial fibroblast cell death includes autophagy and p62 downregulation. In this work, we have studied expression of P-Ser349 p62 in human synovial fibroblasts. Read More

View Article
November 2018

Epstein-Barr virus infection and variants of Epstein-Barr nuclear antigen-1 in synovial tissues of rheumatoid arthritis.

PLoS One 2018 11;13(12):e0208957. Epub 2018 Dec 11.

Department of Internal Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.

Objective: The objective of the present study was to investigate Epstein-Barr virus (EBV) infection as an environmental factor for the development of rheumatoid arthritis (RA).

Methods: Synovial tissues were collected during surgery from 128 RA and 98 osteoarthritis (OA) patients. DNA was extracted from synovial tissues. Read More

View Article
December 2018

Anti-arthritic effect of pentosan polysulfate in rats with collagen-induced arthritis.

Res Vet Sci 2018 Dec 1;122:179-185. Epub 2018 Dec 1.

Department of Veterinary Clinical Sciences, Laboratory of Veterinary Surgery, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

Pentosan polysulfate (PPS) is currently under investigation as a potential disease-modifying antiarthritic agent. In the present study the effects of PPS on arthritic profiles based on clinical score, ankle size, histological changes, and activity of inflammatory mediators using collagen-induced arthritic rat are reported. Model of arthritis was developed in Sprague Dawley rats by intradermal injection of bovine type II collagen emulsified with incomplete Freund's adjuvant. Read More

View Article
December 2018

Cartilage Penetrating Cationic Peptide Carriers for Applications in Drug Delivery to Avascular Negatively Charged Tissues.

Acta Biomater 2018 Dec 6. Epub 2018 Dec 6.

Departments of Bioengineering, Northeastern University, Boston, Massachusetts, USA; Departments of Mechanical Engineering, Northeastern University, Boston, Massachusetts, USA. Electronic address:

Drug delivery to avascular, negatively charged tissues like cartilage remains a challenge. The constant turnover of synovial fluid results in short residence time of administered drugs in the joint space and the dense negatively charged matrix of cartilage hinders their diffusive transport. Drugs are, therefore, unable to reach their cell and matrix targets in sufficient doses, and fail to elicit relevant biological response, which has led to unsuccessful clinical trials. Read More

View Article
December 2018

Influence of anterolateral ligament injuries on stability and second-look arthroscopic findings after allograft transtibial anterior cruciate ligament reconstruction.

Knee 2018 Dec 6. Epub 2018 Dec 6.

Department of Orthopaedic Surgery, Dankook University College of Medicine, Cheonan, Republic of Korea.

Background: The purpose of this study was to evaluate the influence of anterolateral ligament (ALL) injuries on stability and second-look arthroscopic findings after anterior cruciate ligament (ACL) reconstruction.

Methods: One-hundred and nineteen consecutive patients underwent a second-look arthroscopic surgery after ACL reconstruction and magnetic resonance imaging (MRI) examination of the ALL. The patients were divided into an ALL intact group (n = 39) and ALL injured group (n = 80). Read More

View Article
December 2018

Current Trends in Clinical Development of Gene and Cellular Therapeutic Products for Cancer in Japan.

Clin Ther 2018 Dec 6. Epub 2018 Dec 6.

Department of Translational Research Promotion Incubation Center for Advanced Medical Science, Kyushu University, Fukuoka, Japan.

Purpose: In Japan, gene therapy and cellular therapy are categorized as regenerative medicine products based on the Pharmaceuticals and Medical Devices Law that was implemented in 2014. In this new law, regenerative medicine products were newly defined, and a conditional and term-limited approval system for regenerative medicine products was instituted. In addition, the Ministry of Health, Labour and Welfare instituted the SAKIGAKE (meaning pioneer or forerunner in Japanese) designation system in 2015. Read More

View Article
December 2018
1 Read

Update on the epidemiology, risk factors and disease outcomes of osteoarthritis.

Best Pract Res Clin Rheumatol 2018 04 22;32(2):312-326. Epub 2018 Nov 22.

Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, UK & NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

Osteoarthritis (OA) is the most frequent form of arthritis and a leading cause of pain and disability worldwide. OA can affect any synovial joint, although the hip, knee, hand, foot and spine are the most commonly affected sites. Knowledge about the occurrence and risk factors for OA is important to define the clinical and public health burden of the disease to understand mechanisms of disease occurrence and may also help to inform the development of population-wide prevention strategies. Read More

View Article

Cartilage Oligomeric Matrix Protein Levels in Type 2 Diabetes Associated with Primary Knee Osteoarthritis Patients.

Genet Test Mol Biomarkers 2018 Dec 8. Epub 2018 Dec 8.

1 Facultad de Medicina Torreon, Universidad Autonoma de Coahuila , Torreon, Mexico .

Aims: (1) To evaluate the association between type 2 diabetes mellitus (T2D) and primary knee osteoarthritis (KOA) and (2) to compare synovial fluid (SF) cartilage oligomeric matrix protein (COMP) concentrations and glycemic control parameters in patients with T2D, with and without primary KOA.

Methods: A total of 231 individuals were included in this study. Primary KOA was confirmed according to the criteria established by the American College of Rheumatology. Read More

View Article
December 2018

Intra-articular injection of hydrogen sulfide decreased the progression of gonarthrosis.

Can J Physiol Pharmacol 2018 Dec 6:1-8. Epub 2018 Dec 6.

d Department of Pharmacology, University of Giresun, Giresun, Turkey.

Hydrogen sulfide (HS) is found in both the plasma and synovial fluid of patients with gonarthrosis. In the present study, we investigated whether intra-articular injection of sodium hydrosulfide (NaSH) (1 mM, 30 μL), a HS donor, might affect gonarthrosis in rats. Gonarthrosis was induced surgically in the left knees of rats and left for 6 weeks for the development of disease. Read More

View Article
December 2018
4 Reads

Diagnosis and Management of Fungal Periprosthetic Joint Infections.

J Am Acad Orthop Surg 2018 Dec 4. Epub 2018 Dec 4.

From the Sinai Hospital of Baltimore, Baltimore, MD (Dr. Nace), the Philadelphia College of Osteopathic Medicine, Philadelphia, PA (Dr. Siddiqi), the New England Baptist Hospital, Boston, MA (Dr. Talmo), and the Brigham and Women's Hospital, Boston, MA (Dr. Chen).

Fungal periprosthetic joint infection (PJI) is a devastating complication because it can be difficult to diagnose, manage, and eradicate. Fungal PJI treatment requires a systematic approach. Increased awareness is essential when patients with painful arthroplasties present with immunosuppression, significant comorbidities, multiple surgeries, and history of drug use. Read More

View Article
December 2018
2 Reads

Bacterial detection and identification from human synovial fluids on an integrated microfluidic system.

Analyst 2018 Dec 6. Epub 2018 Dec 6.

Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan. and Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan and Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan.

Periprosthetic joint infections (PJIs) are among the most severe complications emerging from prosthetic joint replacement surgeries. In order to possess a rapid means of diagnosing PJIs, an integrated microfluidic system was developed herein for detecting and identifying bacteria in human synovial fluid (HSF). The entire molecular diagnostic process, including (1) sample treatment, (2) bacterial isolation, (3) bacterial lysis, (4) nucleic acid amplification (via polymerase chain reaction (PCR)), and (5) optical detection, could be automated on a single chip. Read More

View Article
December 2018
1 Read

Penetration and efficacy of transdermal NSAIDs in a model of acute joint inflammation.

J Pain Res 2018 13;11:2809-2819. Epub 2018 Nov 13.

InterVivo Solutions Inc, Toronto, ON, Canada.

Purpose: Prescription and OTC non-steroidal anti-inflammatory drugs (NSAIDs) are ubiquitous treatments for pain and inflammation; however, oral administration of these drugs may produce gastrointestinal (GI) side effects. Transdermal (TD) administration of NSAIDs circumvents these adverse events by avoiding the GI tract and, presumably, achieves regional drug levels of therapeutic effect and thereby, fewer off-target complications.

Methods: A drug quantification method was developed for ibuprofen and celecoxib in canine plasma and synovial fluid using liquid chromatography and mass spectrometry. Read More

View Article
November 2018

Ultrasound thresholds for synovial abnormalities.

Authors:
Joanna Collison

Nat Rev Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

Nature Reviews Rheumatology, .

View Article
December 2018

Enriched Cd141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Molecular Rheumatology, School of Medicine, Trinity College Dublin, Ireland.

CD141+ DC are implicated in antiviral and antitumor immunity. However, mechanistic studies in autoimmune disease are limited. This is the first study to our knowledge examining CD141+ DC in autoimmune disease, specifically inflammatory arthritis (IA). Read More

View Article
December 2018

Synovial cysts of the hip joint: a single-center experience.

BMC Surg 2018 Dec 5;18(1):113. Epub 2018 Dec 5.

Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Background: Synovial cyst of the hip joint is a rare clinical condition in need of evidence-based guidelines for its diagnosis and management. Normally, synovial cyst of the hip joint requires no treatment, but when it intrudes into surrounding structures, various clinical symptoms appear. Because of its rarity, a symptomatic synovial cyst is often confounded with a tumor as a space-occupying lesion or with other diseases, depending on its various clinical presentations. Read More

View Article
December 2018
2 Reads

Cannabinoid receptor 2 agonist prevents local and systemic inflammatory bone destruction in rheumatoid arthritis.

J Bone Miner Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Orthopedics, The First Affiliated Hospital of Soochow University.

Cannabinoid receptor 2 (CB2) has been implicated as an important clinical regulator of inflammation and malignant osteolysis. Here, we observed that CB2 expression was markedly higher in the collagen-induced arthritis (CIA) mice synovium and bone tissues than in the non-inflamed synovium and bone tissues. The CB2 selective agonist (JWH133) but not antagonist (SR144528) suppressed CIA in mice without toxic effects, as demonstrated by the decreased synovial hyperplasia, inflammatory responses, cartilage damage, and periarticular and systemic bone destruction. Read More

View Article
December 2018
1 Read

The level of synovial AXL expression determines the outcome of inflammatory arthritis, possibly depending on the upstream role of TGF-β1.

Rheumatology (Oxford) 2018 Dec 1. Epub 2018 Dec 1.

Experimental Rheumatology, Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

Objective: To investigate the role of AXL, a member of the anti-inflammatory TYRO3, AXL MER (TAM) receptor family, in arthritis.

Methods: KRN serum transfer arthritis was induced in Axl-/- and wild-type mice. Knee and ankle joints were scored macro- and microscopically. Read More

View Article
December 2018
1 Read

Synovial sarcoma: when epigenetic changes dictate tumour development.

Swiss Med Wkly 2018 11 2;148:w14667. Epub 2018 Dec 2.

Experimental Pathology Service, Institute of Pathology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland.

Synovial sarcoma is a highly aggressive soft tissue malignancy that often affects adolescents and young adults. It is associated with a unique chromosomal translocation that results in the formation and expression of the fusion gene SS18-SSX, which underlies its pathogenesis. Although SS18-SSX provides a potentially unique therapeutic target, all attempts to neutralise it have been unsuccessful thus far. Read More

View Article
November 2018

Canonical Wnt/β-catenin signaling activation in soft-tissue sarcomas: A comparative study of synovial sarcoma and leiomyosarcoma.

Rare Tumors 2018 25;10:2036361318813431. Epub 2018 Nov 25.

Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

Background: Previous studies have shown that aberrant activation of the Wnt/β-catenin pathway is associated with many malignant neoplasms. This includes some soft-tissue sarcoma phenotypes, most notably synovial sarcoma, implicating potential targets for novel molecular therapies.

Objective: We investigate the level of Wnt/β-catenin pathway activation present in leiomyosarcomas relative to synovial sarcomas, using expression of LEF1 and β-catenin as surrogates. Read More

View Article
November 2018
1 Read

Factors Affecting the Extent of Graft Tendon Synovialization after Double-Bundle Anterior Cruciate Ligament Reconstruction: Based on Second-Look Arthroscopic Findings.

Clin Orthop Surg 2018 Dec 21;10(4):413-419. Epub 2018 Nov 21.

Department of Orthopaedic Surgery, Pohang St. Mary's Hospital, Pohang, Korea.

Background: We aimed to examine the factors that influence synovialization of the grafted tendon after double-bundle anterior cruciate ligament (ACL) reconstruction based on second-look arthroscopic findings.

Methods: Out of 205 knees that were treated between August 2008 and May 2016 with double-bundle ACL reconstruction using bio-absorbable cross-pins and Endobuttons for femoral tunnel fixation, we enrolled 65 knees (64 patients) that underwent second-look arthroscopy with hardware removal at 1 year postoperatively. Measured clinical outcomes included the Lysholm score and Tegner activity score that were evaluated preoperatively and during the final follow-up. Read More

View Article
December 2018
1 Read

Remaining Loose Bodies after Arthroscopic Surgery Including Extensive Capsulectomy for Synovial Chondromatosis of the Hip.

Clin Orthop Surg 2018 Dec 21;10(4):393-397. Epub 2018 Nov 21.

Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: The purpose of our study was to evaluate the usefulness of hip arthroscopy including extensive capsulectomy for synovial chondromatosis of the hip.

Methods: From 2008 to 2016, 13 patients with synovial chondromatosis of the hip were treated with arthroscopic removal of loose bodies and synovectomy using three arthroscopic portals. An extensive capsulectomy was performed to allow the remaining loose bodies to be out of the extracapsular space, and the excised capsule was not repaired. Read More

View Article
December 2018
1 Read

α-Microglobulin Protects Against Bleeding-Induced Oxidative Damage in Knee Arthropathies.

Front Physiol 2018 16;9:1596. Epub 2018 Nov 16.

Department of Clinical Sciences Lund, Orthopaedics, Faculty of Medicine, Lund University, Lund, Sweden.

Knee injury increases the risk of developing knee osteoarthritis (OA). Recent evidence suggests involvement of oxidative stress induced by inflammation and bleeding in the joint. This study investigates the role in this process of α-microglobulin (A1M), a plasma and tissue antioxidant protein with reducing function, and heme- and radical-binding properties. Read More

View Article
November 2018
2 Reads

Vascular endothelial growth factor signaling in VE-cadherin expression and tube-like formation by rheumatoid arthritic synovial fibroblast-like cells.

Biochem Biophys Res Commun 2018 Nov 28. Epub 2018 Nov 28.

Department of Biochemistry, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo, 102-8159, Japan. Electronic address:

An increase in the vasculature is one of most representative changes in the synovial tissue of joints in rheumatoid arthritis (RA) and is closely associated with disease progression. Although the vasculatures are believed to be a result of VE-cadherin-dependent angiogenesis and a possible therapeutic target of the disease, synovial fibroblastic cells express VE-cadherin and form tube-like structures, suggesting that vasculatures in RA synovium may not simply result from angiogenesis. This paper analyzes a mechanism of VE-cadherin expression by rheumatoid arthritic synovial fibroblast-like cells (RSFLs) and their involvement in the tube-like formation. Read More

View Article
November 2018
1 Read

Dyrk1A promotes the proliferation, migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis via down-regulating Spry2 and activating the ERK MAPK pathway.

Tissue Cell 2018 Dec 28;55:63-70. Epub 2018 Oct 28.

Department of Orthopedic, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, 226001, China. Electronic address:

Fibroblast-like synoviocytes (FLSs) play an essential role in rheumatoid arthritis (RA) by promoting synovitis, pannus growth and cartilage/bone destruction. Increased proliferation, migration and invasion of FLSs greatly contribute to RA initiation and progression. Dual-specificity tyrosine-regulated kinase 1A (Dyrk1A), a serine/threonine kinase, regulates MAPK pathway activation, and governs the proliferation and differentiation of neuronal progenitor cells and cancer cells. Read More

View Article
December 2018

Histologic evidence that mast cells contribute to local tissue inflammation in peripheral spondyloarthritis by regulating interleukin-17A content.

Rheumatology (Oxford) 2018 Dec 4. Epub 2018 Dec 4.

Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and Immunology Center.

Objectives: Synovial mast cells contain IL-17A, a key driver of tissue inflammation in SpA. A recent in vitro study showed that tissue-derived mast cells can capture and release exogenous IL-17A. The present study aimed to investigate if this mechanism could contribute to tissue inflammation in SpA. Read More

View Article
December 2018
1 Read

Routine Diagnostic Tests for Periprosthetic Joint Infection Demonstrate a High False-Negative Rate and Are Influenced by the Infecting Organism.

J Bone Joint Surg Am 2018 Dec;100(23):2057-2065

The Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.

Background: Current guidelines recommend serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as the first-line testing for evaluation of suspected periprosthetic joint infection, in addition to synovial white blood-cell (WBC) count and polymorphonuclear percentage. However, the sensitivity and other diagnostic measures of these tests using a standardized definition of periprosthetic joint infection and the influence of organisms on these inflammatory markers remain inadequately investigated.

Methods: A retrospective review of an institutional database of 549 periprosthetic joint infection cases and 653 aseptic total joint arthroplasty revisions was performed. Read More

View Article
December 2018
2 Reads

The Urokinase Plasminogen Activation System in Rheumatoid Arthritis: Pathophysiological Roles and Prospective Therapeutic Targets.

Curr Drug Targets 2018 Dec 4. Epub 2018 Dec 4.

School of Chemistry and Molecular Bioscience, University of Wollongong, NSW 2522. Australia.

Rheumatoid arthritis (RA) is a chronic and progressive inflammatory disease characterized in its early stages by synovial hyperplasia and inflammatory cell infiltration and later by irreversible joint tissue destruction. The plasminogen activation system (PAS) is associated with a wide range of physiological and pathophysiological states involving fibrinolysis, inflammation and tissue remodeling. Various components of the PAS are implicated in the pathophysiology of RA. Read More

View Article
December 2018
1 Read

SPACIA1/SAAL1 Deletion Results in a Moderate Delay in Collagen-Induced Arthritis Activity, along with mRNA Decay of Gene.

Int J Mol Sci 2018 Nov 30;19(12). Epub 2018 Nov 30.

Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa 216-8512, Japan.

This study was performed to elucidate the molecular function of the synoviocyte proliferation-associated in collagen-induced arthritis (CIA) 1/serum amyloid A-like 1 (SPACIA1/SAAL1) in mice CIA, an animal model of rheumatoid arthritis (RA), and human RA-synovial fibroblasts (RASFs). -deficient mice were generated and used to create mouse models of CIA in mild or severe disease conditions. Cell cycle-related genes, whose expression levels were affected by small interfering RNA (siRNA), were screened. Read More

View Article
November 2018

The prophylactic effect of a Eugenia aquea extract against oxidative stress and inflammation associated with the development of arthritis in an adjuvant-induced arthritis rat model.

Food Funct 2018 Dec;9(12):6643-6651

Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt.

Rheumatoid arthritis (RA) is the most common human autoimmune disease. A petroleum ether extract of Eugenia aquea (E. aquea) was analyzed by GC/MS. Read More

View Article
December 2018
4 Reads

Resveratrol Alleviates Rheumatoid Arthritis via Reducing ROS and Inflammation, Inhibiting MAPK Signaling Pathways, and Suppressing Angiogenesis.

J Agric Food Chem 2018 Dec 4. Epub 2018 Dec 4.

Hubei Key Laboratory of EFGIR , Huanggang Normal University , Huanggang , Hubei 438000 , China.

Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting joints and is featured by chronic synovial inflammation and angiogenesis. We employed a bovine type-II collagen (BIIC)-induced Sprague-Dawley rat arthritis model and an in vitro RA model based on interleukin (IL)-1β-stimulated rat synovial cells (RSC-364) to explore the preventive effect of resveratrol on RA and the underlying mechanisms. We found that resveratrol ameliorated BIIC-elicited synovitis and RA-related pathological hallmarks such as inflammatory cell infiltration and angiogenesis in the synovial tissue. Read More

View Article
December 2018
1 Read
2.912 Impact Factor

Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups.

Arthritis Res Ther 2018 Dec 3;20(1):265. Epub 2018 Dec 3.

The Centre for Arthritis and Rheumatic Diseases, Saint Vincent's University Hospital and Dublin Academic Medical Centre, University College Dublin, Elm Park, Dublin, Ireland.

Background: The aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG) and OMERACT Synovial Tissue Biopsy Group.

Methods: Participants were consulted through a modified Delphi method. Three sequential rounds occurred over 12 months. Read More

View Article
December 2018
3 Reads

Correction to: Diffusion-weighted imaging for assessment of synovial inflammation in juvenile idiopathic arthritis: a promising imaging biomarker as an alternative to gadolinium-based contrast agents.

Eur Radiol 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiology, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

The original version of this article, published on 12 June 2017, unfortunately contained a mistake. Read More

View Article
November 2018
1 Read

MRI of THA Correlates With Implant Wear and Tissue Reactions: A Cross-sectional Study.

Clin Orthop Relat Res 2018 Nov 26. Epub 2018 Nov 26.

M. F. Koff, P. Shah, M. Miranda, H. G. Potter, MRI Research Laboratory, Hospital for Special Surgery, New York, NY, USA C. Esposito, E. Baral, T. Wright, Department of Biomechanics, Hospital for Special Surgery, New York, NY, USA K. Fields, Healthcare Research Institute, Hospital for Special Surgery, New York, NY, USA T. Bauer, Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY, USA D. E. Padgett, Adult Reconstruction and Joint Replacement Division, Hospital for Special Surgery, New York, NY, USA.

Background: MRI is predictive of adverse local tissue reactions (ALTRs) after THA but how MRI directly relates to implant surface wear, fretting, and trunnion corrosion at different articulations between implant components remains unclear. MRI generates high-contrast images to display soft tissues around arthroplasty and may provide a surgeon the means to distinguish and differentiate host-related synovial patterns as a response to either polyethylene wear or metal wear and corrosion products.

Questions/purposes: The purposes of this study were (1) to correlate findings from MRI in patients who have undergone THA with direct assessment of implant wear, corrosion, and fretting from retrieved components; and (2) to distinguish the unique synovial responses on MRI in patients who have undergone THA based on bearing materials. Read More

View Article
November 2018
5 Reads

Methyl jasmonate a stress phytohormone attenuates LPS induced in vivo and in vitro arthritis.

Mol Biol Rep 2018 Nov 29. Epub 2018 Nov 29.

Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Velan Nagar, P. V. Vaithiyalingam Road, Pallavaram, Chennai, Tamil Nadu, 600 117, India.

The objective of present study was to screen the effect of methyl jasmonate (MJ) in lipopolysaccharide (LPS) induced in vivo and in vitro arthritis. Arthritis was induced in wistar rats by intraplantar administration of LPS (1 mg/Kg) and effect of MJ was screened in two doses (20, 40 mg/Kg, IP), indomethacin (30 mg/Kg p.o) was used as standard. Read More

View Article
November 2018
3 Reads

Increased Autophagy Enhances the Resistance to Tumor Necrosis Factor-Alpha Treatment in Rheumatoid Arthritis Human Fibroblast-Like Synovial Cell.

Biomed Res Int 2018 25;2018:4941027. Epub 2018 Oct 25.

Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Tumor Necrosis Factor-alpha (TNF-) was reported to increase autophagy in rheumatoid arthritis human fibroblast-like synovial cell (RA-HFLS). We investigated different levels of TNF- exposed to RA-HFLS by focusing on the relationship of autophagy and apoptosis. RA-HFLS and normal human fibroblast-like synovial cell (HFLS) were stimulated by TNF- in the presence or the absence of 3-methyladenine (3-MA) or chloroquine (CQ). Read More

View Article
October 2018
2 Reads

Pseudogout: An Autoimmune Paraneoplastic Manifestation of Myelodysplastic Syndrome.

Cureus 2018 Sep 27;10(9):e3372. Epub 2018 Sep 27.

Internal Medicine, University at Buffalo / Sisters of Charity Hospital, Buffalo, USA.

Myelodysplastic syndrome (MDS) is often associated with autoimmune paraneoplastic manifestations. Seronegative arthritis is among one of them. Very rarely, pseudogout demonstrated as paraneoplastic autoimmune manifestations of MDS has been adumbrated so far. Read More

View Article
September 2018
4 Reads