4,685 results match your criteria Synovial Sarcoma


Localized synovial sarcoma: A single institutional study of 191 patients with a minimum follow-up of 5 years for survivors.

J Surg Oncol 2019 Feb 20. Epub 2019 Feb 20.

Oncology Service, Royal Orthopaedic Hospital, Birmingham, United Kingdom.

Purpose: Factors affecting long-term outcomes of synovial sarcoma (SS) remain unknown. Here, we aimed to investigate the long-term oncological outcomes and prognostic factors in a large group of patients with surgically-treated localized SS.

Patients And Methods: Between 1980 and 2011, 191 patients (94 males and 97 females) were treated at a single hospital with a minimum follow-up of 5 years for survivors. Read More

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http://dx.doi.org/10.1002/jso.25417DOI Listing
February 2019

Machine learning analysis of gene expression data reveals novel diagnostic and prognostic biomarkers and identifies therapeutic targets for soft tissue sarcomas.

PLoS Comput Biol 2019 Feb 20;15(2):e1006826. Epub 2019 Feb 20.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Based on morphology it is often challenging to distinguish between the many different soft tissue sarcoma subtypes. Moreover, outcome of disease is highly variable even between patients with the same disease. Machine learning on transcriptome sequencing data could be a valuable new tool to understand differences between and within entities. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006826DOI Listing
February 2019

Concurrent Papillary Thyroid Carcinoma and Synovial Carcinoma of the Neck in an Adult Male.

Iran J Otorhinolaryngol 2019 Jan;31(102):69-72

Department of Pathology, Aga Khan University hospital, Karachi, Pakistan.

Introduction: Synovial sarcoma makes up 8-10% of all soft tissue sarcomas, and constitutes 3-10% of all sarcomas occurring in the head and neck region. It shows male predominance (3:2), and the mean age of presentation is 30 years.

Case Report: A 51-year-old gentleman presented with right-sided neck swelling which had been progressively increasing in size for the past 2 years. Read More

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January 2019

Genotyping of circulating cell-free DNA enables non-invasive tumor detection in myxoid liposarcomas.

Int J Cancer 2019 Feb 18. Epub 2019 Feb 18.

Department of Plastic and Hand Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Soft tissue sarcomas (STS) are rare tumors of mesenchymal origin. About 50% of patients with STS experience relapse and more than 30% will die within 10 years after diagnosis. In this study we investigated circulating free DNA (cfDNA) and tumor-specific genetic alterations therein (circulating tumor DNA, ctDNA) as diagnostic biomarkers. Read More

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http://dx.doi.org/10.1002/ijc.32216DOI Listing
February 2019

Acute Postoperative Pain Management After Major Limb Amputation in a Pediatric Patient: A Case Report.

J Perianesth Nurs 2019 Feb 8. Epub 2019 Feb 8.

Purpose: Although total prevention of phantom pain is difficult, pediatric patients requiring amputation benefit from an individualized combination of analgesic techniques for phantom pain reduction using a multimodal and interprofessional approach. This is especially useful in the event a single therapy is ineffective for total pain reduction, and may ultimately lead to a reduction in chronic pain development.

Design: Case report with multimodal and interprofessional approach. Read More

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http://dx.doi.org/10.1016/j.jopan.2018.11.004DOI Listing
February 2019

Primary cardiac synovial sarcoma that was continuous with the mitral valve caused severe thrombocytopenia: a case report.

J Cardiothorac Surg 2019 Feb 4;14(1):30. Epub 2019 Feb 4.

Cardiac Surgery Department, Peking University People's Hospital, Beijing, 100044, China.

Background: Primary cardiac sarcomas are exceedingly rare, and they commonly result in nonspecific constitutional symptoms such as shortness of breath, weight loss, and anaemia-related fatigue and malaise. However, thrombocytopenia has very rarely been reported in association with cardiac tumours, either benign or malignant. We report one case of primary cardiac synovial sarcoma continuous with the mitral valve, which was accompanied by severe thrombocytopenia, and the platelet counts returned rapidly to a normal range early after tumour excision and without any special therapies. Read More

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http://dx.doi.org/10.1186/s13019-019-0852-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360734PMC
February 2019
7 Reads

Intraosseous synovial sarcoma of the distal ulna: a case report and review of the literature.

BMC Cancer 2019 Feb 1;19(1):116. Epub 2019 Feb 1.

Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.

Background: Synovial sarcoma is a relatively rare type of soft tissue sarcoma. The commonly observed symptom is a deep-seated palpable mass accompanied by pain or tenderness. Thus, it is considered a soft tissue sarcoma and rarely occurs primarily in bone. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5325-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359868PMC
February 2019
3 Reads

Management of primary retroperitoneal synovial sarcoma: A case report and review of literature.

World J Gastrointest Surg 2019 Jan;11(1):27-33

4 Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, Chaidari, Athens 12462, Greece.

Background: Synovial sarcoma (SS) is a rare type of soft tissue sarcoma that is usually developed from areas where synovial tissue exists, especially at the extremities. Nevertheless, several cases of retroperitoneal SS (RSS) have been described. We herein report a case of RSS presented in our institution. Read More

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http://dx.doi.org/10.4240/wjgs.v11.i1.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354068PMC
January 2019
1 Read

Synovial sarcoma in an HIV-positive pregnant woman and review of literature.

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Hertfordshire HIV Service, Chelsea and Westminster Hospital, London, UK.

We present a first case of synovial sarcoma in an HIV-positive pregnant woman. This 28-year-old woman was diagnosed with synovial sarcoma, a high-grade malignant soft tissue sarcoma, involving her left thigh during the first trimester of her pregnancy. She underwent surgical treatment in the form of hip disarticulation at 30 weeks' gestation. Read More

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http://dx.doi.org/10.1136/bcr-2018-227646DOI Listing
January 2019
1 Read

Histomorphological and Immunohistochemical Analysis of Pleural Neoplasms.

Iran J Pathol 2018 17;13(2):196-204. Epub 2018 Jul 17.

Registrar Pathology, Apollo Hospitals, Bangalore, Bangalore, India.

Background & Objective: Primary pleural neoplasms are rare entities compared with the pleural involvement by metastatic carcinoma.The current study aimed at investigating the complete spectrum of pleural neoplasms and differentiating between them with the aid of immunohistochemistry (IHC).

Methods: Consecutive pleural biopsy specimens positive for a neoplasm, both primary and metastatic, were included in the study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339503PMC
July 2018
1 Read

Poorly differentiated pulmonary synovial sarcoma with SYT gene amplification: A case report.

Mol Clin Oncol 2019 Feb 7;10(2):249-252. Epub 2018 Dec 7.

Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China.

Fluorescence hybridization (FISH) and reverse-transcription polymerase chain reaction (RT-PCR) analysis may be used for the diagnosis of synovial sarcoma (SS), particularly of the poorly differentiated type. While the majority of the studies report that the SYT FISH probe is considered to be break-apart in SS, with two orange and two green signals, the SYT probe in the present case of a 52-year-old male patient with pulmonary SS displayed orange and green signal separation, along with SYT orange signal amplification. RT-PCR was used to verify that the SYT gene amplification was another form of expression of SYT-SSX gene fusion t(X; 18)(p11; q11). Read More

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http://dx.doi.org/10.3892/mco.2018.1787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327209PMC
February 2019

Proteomic signatures corresponding to the SS18/SSX fusion gene in synovial sarcoma.

Oncotarget 2018 Dec 25;9(101):37509-37519. Epub 2018 Dec 25.

Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.

Synovial sarcoma (SS) is a malignant soft tissue lesion and most commonly arises in young adults. Chromosomal translocation t(X;18)(p11;q11) results in the formation of / by gene fusion of the SS18 gene on chromosome 18 to either , , or gene located on chromosome X, which is detected in more than 95% of SSs. Although multiple lines of evidence suggest that the fusion is the oncogene in this tumor, the protein expression profiles associated with / have yet to be elucidated. Read More

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http://dx.doi.org/10.18632/oncotarget.26493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331019PMC
December 2018

STAT6 Expression in Solitary Fibrous Tumor and Histologic Mimics: a Single Institution Experience.

Appl Immunohistochem Mol Morphol 2019 Jan 19. Epub 2019 Jan 19.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

STAT6 stain has proved to be a good surrogate marker for the genetic alteration (NAB2-STAT6 gene fusion) in solitary fibrous tumor (SFT). This study aims to validate the use of STAT6 rabbit monoclonal antibody in differentiating SFT from its histologic mimics. Forty-five cases of SFT and 110 cases from 9 other spindle cell tumors were collected for STAT6 immunostaining. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000745DOI Listing
January 2019
2 Reads

Monophasic synovial sarcoma as a cause of obstructive ileus: A case report.

Mol Clin Oncol 2019 Jan 16;10(1):185-187. Epub 2018 Nov 16.

Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, 11528 Athens, Greece.

Synovial sarcoma is a high-grade soft tissue sarcoma, divided histologically into 3 types: Monophasic, biphasic and poorly differentiated. An extremely rare case of obstructive ileus due to monophasic synovial sarcoma in a 54-year-old male patient is reported in the present study. The patient presented to the emergency department with signs and symptoms of obstructive ileus. Read More

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http://www.spandidos-publications.com/10.3892/mco.2018.1768
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http://dx.doi.org/10.3892/mco.2018.1768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313936PMC
January 2019
5 Reads

New fusion sarcomas histopathology and clinical significance of selected entities.

Hum Pathol 2019 Jan 8. Epub 2019 Jan 8.

Laboratory of Pathology, National Cancer Institute, Bethesda, MD.

Many sarcomas contain gene fusions that can be pathogenetic mechanisms and diagnostic markers. In this article we review selected fusion sarcomas and techniques for their detection. CIC-DUX4 fusion sarcoma is a round-cell tumor now considered an entity separate from Ewing sarcoma with a more aggressive clinical course, occurrence in older age, and predilection to soft tissues. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.006DOI Listing
January 2019
10 Reads

Pediatric Tonsillar Synovial Sarcoma- Very Rare Localization: A Case Report and Review of the Literature.

Turk Patoloji Derg 2019 Jan 11. Epub 2019 Jan 11.

Department of Pediatric Hematology and Oncology, Akdeniz University Medicine Faculty, ANTALYA, TURKEY.

Tonsillar synovial sarcoma is an extremely rare entity and only 9 adult patients have been reported up to now. Here, we describe the first pediatric tonsillar synovial sarcoma of the literature in a patient who presented with a 2-month history of dysphagia and snoring. Clinical and radiological examinations showed that the tumor arose from the right palatine tonsil and narrowed the parapharyngeal space. Read More

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http://www.turkjpath.org/doi.php?doi=10.5146/tjpath.2018.014
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http://dx.doi.org/10.5146/tjpath.2018.01449DOI Listing
January 2019
5 Reads

Analysis of mutations in primary and metastatic synovial sarcoma.

Oncotarget 2018 Dec 7;9(96):36878-36888. Epub 2018 Dec 7.

The Children's Guild Foundation Down Syndrome Research Program, Genetics and Genomics Program, Department of Cancer Genetics and Genomics, Roswell Park Cancer Institute, Buffalo, NY, USA.

Synovial sarcoma is the most common pediatric non-rhabdomyosarcoma soft tissue sarcoma and accounts for about 8-10% of all soft tissue sarcoma in childhood and adolescence. The presence of a chromosomal translocation-associated -fusion gene is causally linked to development of primary synovial sarcoma. Metastases occur in approximately 50-70% of synovial sarcoma cases with yet unknown mechanisms, which led to about 70-80% mortality rate in five years. Read More

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http://www.oncotarget.com/fulltext/26416
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http://dx.doi.org/10.18632/oncotarget.26416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305143PMC
December 2018
4 Reads

Primary Synovial Sarcoma of the Mediastinum with Long-term Follow-up.

Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Department of Pulmonary Medicine, Thoracic Center, St. Luke's International Hospital, Japan.

Chest radiography showed a right posterior mass on the mediastinum of an 84-year-old woman. The mass had been growing gradually for four years. Surgical excision was performed, and a pathological examination found the mass to be consistent with primary synovial sarcoma (SS) of the mediastinum. Read More

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http://dx.doi.org/10.2169/internalmedicine.2199-18DOI Listing
January 2019
1 Read

Primary Orbital Synovial Sarcoma Mimicking a Periocular Cyst.

Am J Dermatopathol 2019 Jan 3. Epub 2019 Jan 3.

Unit of Ocular Oncology, Department of Surgery and Translational Medicine, Careggi University Hospital, Florence, Italy.

Synovial sarcoma (SS) is a high-grade soft-tissue sarcoma occurring predominantly in older children and young adults. Only approximately 7% occur in the head and neck region, with SS representing less than 0.1% of all head and neck cancers. Read More

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http://Insights.ovid.com/crossref?an=00000372-900000000-9822
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http://dx.doi.org/10.1097/DAD.0000000000001351DOI Listing
January 2019
2 Reads

Sports activity after soft tissue sarcoma of the lower extremity.

Disabil Rehabil 2019 Jan 8:1-6. Epub 2019 Jan 8.

a Department of Orthopaedic Surgery , Medical University of Vienna, Vienna General Hospital , Vienna , Austria.

Introduction: The aim of this case series was to assess sports activity levels in long-term survivors of soft-tissue sarcomas after multimodal treatment including limb salvaging surgical resection and radio-chemotherapy.

Methods: Thirty-two patients (17 f/15 m) with a mean age of 29 (range 10-44) years at the time of diagnosis and a mean follow-up time of 9 (range 3-21) years following sarcoma were included. Ten patients had been diagnosed with liposarcoma, seven with synovial sarcoma, four with fibrosarcoma, three with undifferentiated pleomorphic sarcomas and the remaining eight patients with different soft-tissue sarcoma entities. Read More

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https://www.tandfonline.com/doi/full/10.1080/09638288.2018.1
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http://dx.doi.org/10.1080/09638288.2018.1520929DOI Listing
January 2019
6 Reads

Gouty Tophi in Sinus Tarsi of Bilateral Feet Mimicking Synovial Sarcoma:A Case Report.

J Foot Ankle Surg 2019 Jan 3. Epub 2019 Jan 3.

Director, Podiatric Surgical Residency, Beaumont Hospital Wayne, Wayne, MI.

Chronic gout is defined as accumulation of monosodium urate crystals in joints, cartilage, tendons, bursae, bone, and soft tissue. The foot is the most common location for acute gout flares, with the first metatarsophalangeal joint being the most frequent site of tophus formation. However, few studies have reported gouty tophus formation in the subtalar joint. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.08.031DOI Listing
January 2019
1 Read

Distal extremities soft tissue sarcomas: Are they so different from other limb localizations?

J Surg Oncol 2019 Mar 4;119(4):479-488. Epub 2019 Jan 4.

Faculté de Médecine de la Timone, Génétique Médicale et génomique fonctionnelle, UMR S910 Inserm, Université Aix-Marseille 2, Marseille, France.

Background And Objectives: Soft tissue sarcoma localization in distal extremities (DESTS) of the limbs (hand/fingers, and foot/toes) is unusual. The literature is scarce about their behavior and this study was designed to assess their epidemiological characteristics, outcomes, and prognosis compared to other limb localizations (OLSTS).

Methods: From 1980 to 2010, adult DESTS and OLSTS in 22 centers were included. Read More

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http://dx.doi.org/10.1002/jso.25359DOI Listing
March 2019
2 Reads

Frequent TLE1 Expression in Cutaneous Neoplasms.

Am J Dermatopathol 2019 Jan;41(1):1-6

Dermatopathologist, Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA.

TLE1 immunohistochemistry is widely used as a biomarker for synovial sarcoma. Recently, we identified TLE1 expression in a subset of melanomas and noted staining in sebaceous glands and follicular epithelium. TLE1 immunohistochemistry has not been well studied in cutaneous tumors. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001186DOI Listing
January 2019
2 Reads

FDG PET/CT Findings of a Synovial Sarcoma in a Renal Transplant.

Clin Nucl Med 2019 Mar;44(3):259-261

From the Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, China.

A 48-year old man who underwent renal transplantation 2 years ago due to chronic renal failure underwent FDG PET/CT to determine the etiology of multiple lesions in the renal transplant incidentally found on routine examination. The images demonstrated several foci of the abnormally increased activity in the transplanted kidney with SUVmax of 7.5. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002429DOI Listing
March 2019
1 Read
3.931 Impact Factor

An update of molecular pathology of bone tumors. Lessons learned from investigating samples by next generation sequencing.

Genes Chromosomes Cancer 2019 02 24;58(2):88-99. Epub 2018 Dec 24.

Department of Pathology, The Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom.

The last decade has seen the majority of primary bone tumor subtypes become defined by molecular genetic alteration. Examples include giant cell tumour of bone (H3F3A p.G34W), chondroblastoma (H3F3B p. Read More

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http://doi.wiley.com/10.1002/gcc.22699
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http://dx.doi.org/10.1002/gcc.22699DOI Listing
February 2019
6 Reads

A Rare Case of Monophasic Synovial Sarcoma of Thoracic Vertebra.

Case Rep Med 2018 18;2018:2313927. Epub 2018 Nov 18.

Raritan Bay Medical Center, Perth Amboy, NJ, USA.

Synovial sarcoma of spine is an extremely rare malignancy with poor prognosis. It is often metastatic at the time of presentation. Its relative rarity and histological resemblance to other tumors make it diagnostically challenging, requiring the need of immunohistochemistry and cytogenetics for definite diagnosis. Read More

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http://dx.doi.org/10.1155/2018/2313927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276405PMC
November 2018
1 Read

Gastric Synovial Sarcoma.

J Gastrointest Surg 2018 Dec 18. Epub 2018 Dec 18.

General Surgery Department, Hospital Italiano de Buenos Aires, Juan D. Perón 4190, C1199ABD, Buenos Aires, Argentina.

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http://dx.doi.org/10.1007/s11605-018-4065-6DOI Listing
December 2018
1 Read

A recurrent novel fusion identifies a new subtype of high-grade spindle cell sarcoma.

Cold Spring Harb Mol Case Stud 2018 Dec 17;4(6). Epub 2018 Dec 17.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

-rearranged tumors are defined by the presence of a gene fusion between and various gene partners and typically follow a clinically aggressive disease course with poor outcomes despite conventional multimodality therapy. -rearranged tumors display histologic features of a poorly differentiated carcinoma with areas of focal squamous differentiation and typically express the fusion gene defining a distinct clinicopathologic entity-NUT carcinoma (NC). NCs with mesenchymal differentiation have rarely been described in the literature. Read More

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http://molecularcasestudies.cshlp.org/lookup/doi/10.1101/mcs
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http://dx.doi.org/10.1101/mcs.a003194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318763PMC
December 2018
17 Reads

Primary thyroid biphasic synovial sarcoma and synchronous papillary carcinoma: report of a remarkable case.

Pathologica 2018 Sep;110(2):106-110

Pathology Unit, Garbagnate Milanese Hospital, ASST Rhodense, Italy.

Synovial Sarcoma (SS) is the fourth most common soft tissue sarcoma, characterized by translocation t(X;18) (p11.2;q11.2). Read More

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September 2018
8 Reads

PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy.

Oncoimmunology 2018 11;7(12):e1507600. Epub 2018 Sep 11.

Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.

Synovial sarcoma expresses multiple cancer testis antigens that could potentially be targeted by T-cell receptor (TCR) gene therapy. In this study we investigated whether PRAME-TCR-gene therapy could be an effective treatment for synovial sarcoma by investigating the potential of PRAME-specific T-cells to recognize sarcoma cells and by evaluating the expression patterns of and HLA class I (HLA-I) in synovial sarcoma tumor samples. All expressing sarcoma cell lines, including 2 primary synovial sarcoma cell cultures (passage < 3), were efficiently recognized by PRAME-specific T-cells. Read More

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http://dx.doi.org/10.1080/2162402X.2018.1507600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279314PMC
September 2018
1 Read
6.283 Impact Factor

A Case of Primary Intra-abdominal Synovial Sarcoma.

Indian J Surg Oncol 2018 Dec 22;9(4):636-639. Epub 2018 May 22.

2Department of General and Gastrointestinal Surgery, Medical Trust Hospital, M.G. Road, Kochi, Kerala 682016 India.

Synovial sarcomas are relatively common intermediate-to-high-grade malignant soft tissue tumors, often with an initial indolent course. And among the sarcomas primary intra-abdominal synovial sarcoma is a relatively rare entity that may present with an abdominal mass and diagnosis is usually confirmed by immunohistochemistry. The authors report a case of a 46-year-old man who presented with a large palpable abdominal mass. Read More

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http://dx.doi.org/10.1007/s13193-018-0783-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265165PMC
December 2018
1 Read

Current Trends in Clinical Development of Gene and Cellular Therapeutic Products for Cancer in Japan.

Clin Ther 2019 Jan 7;41(1):174-184.e3. Epub 2018 Dec 7.

Department of Translational Research Promotion Incubation Center for Advanced Medical Science, Kyushu University, Fukuoka, Japan.

Purpose: In Japan, gene therapy and cellular therapy are categorized as regenerative medicine products based on the Pharmaceuticals and Medical Devices Law that was implemented in 2014. In this new law, regenerative medicine products were newly defined, and a conditional and term-limited approval system for regenerative medicine products was instituted. In addition, the Ministry of Health, Labour and Welfare instituted the SAKIGAKE (meaning pioneer or forerunner in Japanese) designation system in 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01492918183055
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http://dx.doi.org/10.1016/j.clinthera.2018.11.003DOI Listing
January 2019
9 Reads

Synovial sarcoma: when epigenetic changes dictate tumour development.

Swiss Med Wkly 2018 11 2;148:w14667. Epub 2018 Dec 2.

Experimental Pathology Service, Institute of Pathology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland.

Synovial sarcoma is a highly aggressive soft tissue malignancy that often affects adolescents and young adults. It is associated with a unique chromosomal translocation that results in the formation and expression of the fusion gene SS18-SSX, which underlies its pathogenesis. Although SS18-SSX provides a potentially unique therapeutic target, all attempts to neutralise it have been unsuccessful thus far. Read More

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http://dx.doi.org/10.4414/smw.2018.14667DOI Listing
November 2018
1 Read

Canonical Wnt/β-catenin signaling activation in soft-tissue sarcomas: A comparative study of synovial sarcoma and leiomyosarcoma.

Rare Tumors 2018 25;10:2036361318813431. Epub 2018 Nov 25.

Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

Background: Previous studies have shown that aberrant activation of the Wnt/β-catenin pathway is associated with many malignant neoplasms. This includes some soft-tissue sarcoma phenotypes, most notably synovial sarcoma, implicating potential targets for novel molecular therapies.

Objective: We investigate the level of Wnt/β-catenin pathway activation present in leiomyosarcomas relative to synovial sarcomas, using expression of LEF1 and β-catenin as surrogates. Read More

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http://dx.doi.org/10.1177/2036361318813431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256314PMC
November 2018
2 Reads

Targeting regulation of cyclin dependent kinase 9 as a novel therapeutic strategy in synovial sarcoma.

J Orthop Res 2018 Nov 28. Epub 2018 Nov 28.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of California Los Angeles, 615 Charles E. Young Dr. S., Los Angeles, California, 90095.

Synovial sarcomas hold a low genomic complexity, making it distinct from other types of soft-tissue sarcomas. Many studies focused on targeting the SS18-SSX fusion protein, which presents in over 90% of human synovial sarcomas. This protein acts as an oncogenic promoter in the tumorigenesis of synovial sarcomas, making it an ideal therapeutic target. Read More

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http://dx.doi.org/10.1002/jor.24189DOI Listing
November 2018
10 Reads

Aortic saddle embolism following pneumonectomy for synovial sarcoma of lung.

ANZ J Surg 2018 Nov 28. Epub 2018 Nov 28.

Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1111/ans.14929DOI Listing
November 2018
1 Read

Laryngeal synovial sarcoma: Report of 2 cases.

J Egypt Natl Canc Inst 2018 Dec 24;30(4):173-176. Epub 2018 Nov 24.

ENT Department, Farhat Hached University Hospital, Sousse, Tunisia.

Synovial sarcoma is a malignant mesenchymal tumor. It most commonly occurs in the lower extremities of young adults. The head and neck are rare sites, accounting for less than 10%. Read More

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http://dx.doi.org/10.1016/j.jnci.2018.10.002DOI Listing
December 2018
14 Reads

Synovial sarcoma of the aortopulmonary window.

J Card Surg 2018 Dec 22;33(12):797-798. Epub 2018 Nov 22.

Cardiovascular Surgeon, Department of Cardiovascular Surgery, Virgen de las Nieves University Hospital, Granada, Spain.

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http://dx.doi.org/10.1111/jocs.13951DOI Listing
December 2018

Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.

Head Neck Pathol 2018 Nov 22. Epub 2018 Nov 22.

Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.

Head and neck pathology present a unique set of challenges including the morphological diversity of the neoplasms and presentation of metastases of unknown primary origin. The detection of human papillomavirus and Epstein-Barr virus associated with squamous cell carcinoma and newer entities like HPV-related carcinoma with adenoid cystic like features have critical prognostic and management implications. In salivary gland neoplasms, differential diagnoses can be broad and include non-neoplastic conditions as well as benign and malignant neoplasms. Read More

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http://dx.doi.org/10.1007/s12105-018-0988-1DOI Listing
November 2018
10 Reads

Pazopanib-induced changes in protein expression signatures of extracellular vesicles in synovial sarcoma.

Biochem Biophys Res Commun 2018 Nov 27;506(3):723-730. Epub 2018 Oct 27.

Division of Rare Cancer Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan; Department of Innovative Seeds Evaluation, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. Electronic address:

Secreted proteins enclosed in extracellular vesicles can act as intercellular messengers. The objective of this study was to elucidate the role of proteins secreted from synovial sarcoma cells in the regulatory network underlying pazopanib response. We performed a comprehensive analysis of expression of proteins secreted from four synovial sarcoma cell lines (SYO-1, HS-SYII, 1273/99, and YaFuSS) using mass spectroscopy. Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.10.012DOI Listing
November 2018
5 Reads

[A Case Report of Primary Pulmonary Synovial Sarcoma with Postoperative Multiple Metastases Treated with Apatinib].

Zhongguo Fei Ai Za Zhi 2018 Nov;21(11):880-884

Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Shandong Cancer Hospital 
and Institute, Jinan 250117, China.

Primary pulmonary synovial sarcoma is a rare pulmonary malignant tumor originated from primitive mesenchymal, which has short overall survival and poor prognosis. Related case reports are lacked at home and abroad. In recent years, the development of targeted therapy has brought remarkable benefits to cancer patients. Read More

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http://www.lungca.org/index.php?journal=01&page=article&
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http://dx.doi.org/10.3779/j.issn.1009-3419.2018.11.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247001PMC
November 2018
10 Reads

Diagnostic Imaging and Management of Common Intra-articular and Peri-articular Soft Tissue Tumors and Tumorlike Conditions of the Knee.

J Knee Surg 2018 Nov 16. Epub 2018 Nov 16.

Department of Orthopedic Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina.

Intra-articular (IA) and peri-articular (PA) tumors of the knee are frequently encountered by orthopaedic surgeons. Nonetheless, due to the possibility of great morbidity and potential mortality, it is important to recognize and differentiate between benign and malignant lesions in a timely manner. Therefore, the purpose of this article is to provide a concise, practical, and updated review of commonly encountered IA and PA tumors including intratendinous gout, synovial chondromatosis, schwannoma, pigmented villonodular synovitis, and synovial sarcoma, and a detailed description of differentiating features to include various imaging modalities. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1675609
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http://dx.doi.org/10.1055/s-0038-1675609DOI Listing
November 2018
9 Reads

Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma.

Elife 2018 11 15;7. Epub 2018 Nov 15.

Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston Children's Hospital and Harvard Medical School, Boston, United States.

Synovial sarcoma tumours contain a characteristic fusion protein, SS18-SSX, which drives disease development. Targeting oncogenic fusion proteins presents an attractive therapeutic opportunity. However, SS18-SSX has proven intractable for therapeutic intervention. Read More

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http://dx.doi.org/10.7554/eLife.41305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277197PMC
November 2018
16 Reads
8.520 Impact Factor

miR‑494.3p expression in synovial sarcoma: Role of CXCR4 as a potential target gene.

Int J Oncol 2019 Jan 6;54(1):361-369. Epub 2018 Nov 6.

Laboratory of Experimental Oncology, IRCCS, Rizzoli Orthopedic Institute, I‑40136 Bologna, Italy.

Synovial sarcoma (SS) is a rare tumour, with dismal survival when metastasis occurs. SS contains a characteristic translocation (X;18)(p11;q11) and the fusion genes appear to be mutually exclusive and concordant in primary and metastatic tumours. Novel prognostic and predictive factors are required. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2018.4627
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http://dx.doi.org/10.3892/ijo.2018.4627DOI Listing
January 2019
12 Reads

Clinicopathological features, treatment and survival outcomes of synovial sarcoma.

South Asian J Cancer 2018 Oct-Dec;7(4):270-272

Department of Medical Oncology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Introduction: Synovial sarcoma (SS) is a malignant mesenchymal tumor. It is most common among children and adults. The data on SS from India are scarce. Read More

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http://journal.sajc.org/text.asp?2018/7/4/270/242798
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http://dx.doi.org/10.4103/sajc.sajc_269_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190396PMC
November 2018
11 Reads

Synovial sarcoma of bone: Sarcoma typically of soft tissues presenting as a primary bone tumor.

Radiol Case Rep 2019 Feb 9;14(2):204-207. Epub 2018 Nov 9.

Department of Sarcoma, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA.

Synovial sarcoma typically presents as periarticular soft tissue mass in adolescent and young adult patients. Very rarely, soft tissue sarcomas may arise primarily within bone posing a significant diagnostic challenge as primary osseous malignancies such as osteosarcoma and metastatic disease are much more common. While tissue sampling with immunohistochemical and genetic testing are required for definitive diagnosis, radiologists and orthopedic oncologists should consider alternate etiologies when typical imaging features of more common bone tumors are not identified. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433183046
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http://dx.doi.org/10.1016/j.radcr.2018.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231113PMC
February 2019
10 Reads