4,893 results match your criteria Synovial Sarcoma


Feasibility of Targeting Traf2-and-Nck-Interacting Kinase in Synovial Sarcoma.

Cancers (Basel) 2020 May 16;12(5). Epub 2020 May 16.

Laboratory of Collaborative Research, Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo 104-0045, Japan.

Background: The treatment of patients with metastatic synovial sarcoma is still challenging, and the development of new molecular therapeutics is desirable. Dysregulation of Wnt signaling has been implicated in synovial sarcoma. Traf2-and-Nck-interacting kinase (TNIK) is an essential transcriptional co-regulator of Wnt target genes. Read More

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http://dx.doi.org/10.3390/cancers12051258DOI Listing

Neoadjuvant Chemotherapy in High-Risk Soft Tissue Sarcomas: Final Results of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish (PSG) Sarcoma Groups.

J Clin Oncol 2020 May 18:JCO1903289. Epub 2020 May 18.

Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Purpose: To determine whether the administration of histology-tailored neoadjuvant chemotherapy (HT) was superior to the administration of standard anthracycline plus ifosfamide neoadjuvant chemotherapy (A+I) in high-risk soft tissue sarcoma (STS) of an extremity or the trunk wall.

Patients And Methods: This was a randomized, open-label, phase III trial. Patients had localized high-risk STS (grade 3; size, ≥ 5 cm) of an extremity or trunk wall, belonging to one of the following five histologic subtypes: high-grade myxoid liposarcoma (HG-MLPS); leiomyosarcoma (LMS), synovial sarcoma (SS), malignant peripheral nerve sheath tumor (MPNST), and undifferentiated pleomorphic sarcoma (UPS). Read More

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http://dx.doi.org/10.1200/JCO.19.03289DOI Listing

Left Atrial High-grade Sarcoma With Focal Osteosarcomatous Differentiation.

Cureus 2020 Apr 13;12(4):e7660. Epub 2020 Apr 13.

Cardiology, Palmetto General Hospital, Hialeah, USA.

Approximately 75% of cardiac tumors are benign, and 25% are malignant cardiac tumors. Of these, sarcomas are extremely rare and have been described in isolated case reports. Due to its rarity, there is no published guideline for the management of this pathological entity. Read More

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http://dx.doi.org/10.7759/cureus.7660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219016PMC

Tumor Mutation Burden and Checkpoint Immunotherapy Markers in Primary and Metastatic Synovial Sarcoma.

Hum Pathol 2020 May 5. Epub 2020 May 5.

Department of Pathology & Immunology, Washington University at St. Louis School of Medicine, St. Louis, MO 63110.

Synovial sarcoma (SS) is a soft-tissue malignancy that most often affects patients between 15 to 40 years, and the prognosis for patients with metastatic disease is generally poor. This study was performed to evaluate checkpoint blockade immunotherapy markers in SS, including tumor mutational burden (TMB), DNA mismatch repair (MMR) status, PDL-1, PD1 and CD8 expression by normal - tumor paired whole exome sequencing (WES) and immunohistochemistry (IHC). Outcomes evaluated included event free and overall survival. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.04.007DOI Listing

Synovial sarcoma presenting as an intra-articular mass in a pediatric patient: a case report.

BMC Musculoskelet Disord 2020 May 7;21(1):283. Epub 2020 May 7.

Department of Orthopaedics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Background: Synovial sarcoma (SS) is one of the reported sarcomas in the pediatric and adult populations. Delay in diagnosis and treatment is common in SS cases. SS may be excised before the correct diagnosis is made. Read More

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http://dx.doi.org/10.1186/s12891-020-03312-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206690PMC

Metastatic Soft Tissue Sarcomas in Adolescents and Young Adults: A Specialist Center Experience.

J Adolesc Young Adult Oncol 2020 May 5. Epub 2020 May 5.

Sarcoma Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom.

Soft tissue sarcomas (STS) account for 8% of all cancers in adolescents and young adults (AYAs). Metastatic STS contribute significantly to disease-related mortality in this age group; however, data are limited due to under-representation in clinical trials. AYAs aged 18-39 years, diagnosed with metastatic STS between 1990 and 2012, were identified from The Royal Marsden Hospital database. Read More

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http://dx.doi.org/10.1089/jayao.2020.0010DOI Listing

Clinical outcomes of patients with advanced synovial sarcoma or myxoid/round cell liposarcoma treated at major cancer centers in the United States.

Cancer Med 2020 May 6. Epub 2020 May 6.

Mayo Clinic, Jacksonville, FL, USA.

Background: Outcomes data regarding advanced synovial sarcoma (SS) and myxoid/round cell liposarcoma (MRCL) are limited, consisting primarily of retrospective series and post hoc analyses of clinical trials.

Methods: In this multi-center retrospective study, data were abstracted from the medical records of 350 patients from nine sarcoma centers throughout the United States and combined into a registry. Patients with advanced/unresectable or metastatic SS (n = 249) or MRCL (n = 101) who received first-line systemic anticancer therapy and had records of tumor imaging were included. Read More

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http://dx.doi.org/10.1002/cam4.3039DOI Listing

Primary tracheal synovial sarcoma: a rare clinical entity with diagnostic challenges.

J Egypt Natl Canc Inst 2020 Jan 10;32(1). Epub 2020 Jan 10.

Department of Surgical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences (AIIMS), F 23, Ansari Nagar (West), New Delhi, 110029, India.

Background: The incidence of primary tracheal tumors is very low. Tracheal synovial sarcoma (SS) is even an extremely rare entity. Diagnosis of tracheal SS can be achieved with chromosomal translocation studies along with immunohistochemistry. Read More

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http://dx.doi.org/10.1186/s43046-019-0014-zDOI Listing
January 2020

Immunophenotype-Genotype Correlations in Clear Cell Sarcoma of Kidney-An Evaluation of Diagnostic Ancillary Studies.

Pediatr Dev Pathol 2020 May 4:1093526620910658. Epub 2020 May 4.

Trinity College, University of Dublin, Dublin, Ireland.

Introduction: The purpose of this study was to establish a reliable panel of antibodies for immunohistochemical corroboration of a diagnosis of clear cell sarcoma of kidney (CCSK), taking into consideration the various genotypic subsets of CCSK.

Methods: We conducted full genotypic analysis for evidence of internal tandem duplication (ITD), and in 68 archival cases of CCSK and then immunostained all cases for CCND1, TLE1, and BCOR along with 63 control samples representing tumor types that may enter into the differential diagnosis of CCSK, including 7 congenital mesoblastic nephromas, 2 desmoplastic small round cell tumors, 13 malignant rhabdoid tumors, 9 Ewing sarcomas/primitive neuroectodermal tumor, 5 synovial sarcomas, and 27 Wilms' tumors.

Results: Molecular assays showed that 54 CCSKs harbored a -ITD, 1 case expressed a fusion transcript while none expressed the fusion. Read More

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http://dx.doi.org/10.1177/1093526620910658DOI Listing

Primary Renal Mesenchymal Neoplasms in Nephrectomy Specimens: A 16-Year Survey of Primary and Incidental Cases From a Single Institution.

Int J Surg Pathol 2020 May 4:1066896920916780. Epub 2020 May 4.

Indiana University, Indianapolis, IN, USA.

. Primary renal mesenchymal neoplasms are rare but diverse. Several neoplasms of mesenchymal derivation can arise as a primary renal mass; however, incidental tumors are identified in nephrectomies performed for end-stage renal disease or other malignant epithelial renal neoplasms. Read More

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http://dx.doi.org/10.1177/1066896920916780DOI Listing
May 2020
0.961 Impact Factor

Clinical and Radiologic Features Together Better Predict Lung Nodule Malignancy in Patients with Soft-Tissue Sarcoma.

J Clin Med 2020 Apr 23;9(4). Epub 2020 Apr 23.

Cardiovascular Research Institute Maastricht-CARIM, Maastricht University Medical Center, 6229 ER Maastricht, The Netherlands.

We test the hypothesis that a model including clinical and computed tomography (CT) features may allow discrimination between benign and malignant lung nodules in patients with soft-tissue sarcoma (STS). Seventy-one patients with STS undergoing their first lung metastasectomy were examined. The performance of multiple logistic regression models including CT features alone, clinical features alone, and combined features, was tested to evaluate the best model in discriminating malignant from benign nodules. Read More

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http://dx.doi.org/10.3390/jcm9041209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230600PMC

Phase I expansion cohort to evaluate the combination of bevacizumab, sorafenib and low-dose cyclophosphamide in children and young adults with refractory or recurrent solid tumours.

Eur J Cancer 2020 Jun 20;132:35-42. Epub 2020 Apr 20.

Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Keck School of Medicine, Los Angeles, CA 90027, USA.

Background: Angiogenesis is critical for tumour growth and metastasis. Dual inhibition of vascular endothelial growth factors and platelet-derived growth factor receptors suppresses angiogenesis. This expansion cohort of a phase I study targeted angiogenesis with sorafenib, bevacizumab and low-dose cyclophosphamide in children and young adults with recurrent solid tumours. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.03.010DOI Listing

Diagnostic Value of TLE1 in Synovial Sarcoma: A Systematic Review and Meta-Analysis.

Sarcoma 2020 29;2020:7192347. Epub 2020 Jan 29.

Department of Orthopaedic Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Synovial sarcoma can present morphologically in multiple forms, including biphasic and monophasic subtypes. As a result, the histological diagnosis can sometimes be challenging. Transducin-Like Enhancer 1 (TLE1) is a transcriptional corepressor that normally is involved in embryogenesis and hematopoiesis but is also expressed in certain tumors. Read More

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http://dx.doi.org/10.1155/2020/7192347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166261PMC
January 2020

PRIMARY CUTANEOUS SOLITARY FIBROUS TUMOR WITH ENTRAPPED ECCRINE COMPONENTS.

Authors:
Tien Anh N Tran

J Cutan Pathol 2020 Apr 20. Epub 2020 Apr 20.

Department of Pathology, Advent Health Orlando, 601 East Rollins St., Orlando, Florida.

First described in the pleura, solitary fibrous tumor (SFT) had been subsequently reported in a variety of organ systems. Compared to other anatomic sites, primary cutaneous and superficial SFTs are relatively rare. Although several histologic variants of cutaneous and superficial SFT have been described, a primary cutaneous SFT harboring glandular components has not hitherto been documented in the literature. Read More

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http://dx.doi.org/10.1111/cup.13717DOI Listing

Sarcoma metastasis to the pancreas: experience at a single institution.

J Pathol Transl Med 2020 Apr 22. Epub 2020 Apr 22.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Reports of metastatic sarcoma to the pancreas are limited. We reviewed the clinicopathologic characteristics of such cases.

Materials And Methods: We reviewed 124 cases of metastatic tumors to the pancreas diagnosed at Asan Medical Center between 2000 and 2017. Read More

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http://dx.doi.org/10.4132/jptm.2020.03.04DOI Listing

Gastric synovial sarcoma: a case report and literature review.

Hong Kong Med J 2020 Apr;26(2):142-145

Department of Pathology, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong.

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http://dx.doi.org/10.12809/hkmj197986DOI Listing

Prevalence of PD-L1 expression in matched recurrent and/or metastatic sarcoma samples and in a range of selected sarcomas subtypes.

PLoS One 2020 15;15(4):e0222551. Epub 2020 Apr 15.

Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Australia.

We assessed the frequency of programmed death-ligand 1 (PD-L1) expression by immunohistochemistry (IHC) in a cohort of 522 sarcomas from 457 patients, incuding a subset of 46 patients with 63 matched samples from local recurrence or metastases with primary tumours and/or metachronous metastases. We also investigated the correlation of PD-L1 with the presence and degree of tumour-infiltrating lymphocytes (TILs) in a subset of cases. IHC was performed using the PD-L1 SP263 companion kit (VENTANA) on tissue microarrays from an archival cohort. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222551PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159201PMC

Complications of muscle hematomas in hemophilia.

Cardiovasc Hematol Disord Drug Targets 2020 Apr 15. Epub 2020 Apr 15.

Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Paseo de la Castellana 261, 28046-Madrid. Spain.

Prevention is essential for avoiding the complications of muscle hematomas (compartment syndrome, pseudotumous and peripheral nerve lesions) in hemophilic patients. This is achieved through early diagnosis of muscle hematomas and proper long-term hematological treatment until they have resolved (confirmed by image studies). Ultrasound-guided percutaneous drainage could be beneficial in terms of achieving better and faster symptom relief. Read More

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http://dx.doi.org/10.2174/1871529X20666200415121409DOI Listing

Underlying Ossification Phenotype in a Murine Model of Metastatic Synovial Sarcoma.

Int J Mol Sci 2020 Apr 10;21(7). Epub 2020 Apr 10.

Department of Biomedical and Pharmaceutical Sciences, Idaho State University, Pocatello, ID 83201, USA.

Synovial sarcoma, an uncommon cancer, typically affects young adults. Survival rates range from 36% to 76%, decreasing significantly when metastases are present. Synovial sarcomas form in soft tissues, often near bones, with about 10% demonstrating ossification in the tumor. Read More

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http://dx.doi.org/10.3390/ijms21072636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177647PMC

Hydra: A mixture modeling framework for subtyping pediatric cancer cohorts using multimodal gene expression signatures.

PLoS Comput Biol 2020 Apr 10;16(4):e1007753. Epub 2020 Apr 10.

Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America.

Precision oncology has primarily relied on coding mutations as biomarkers of response to therapies. While transcriptome analysis can provide valuable information, incorporation into workflows has been difficult. For example, the relative rather than absolute gene expression level needs to be considered, requiring differential expression analysis across samples. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1007753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176284PMC

Heparanase: A Potential Therapeutic Target in Sarcomas.

Adv Exp Med Biol 2020 ;1221:405-431

Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Sarcomas comprise a heterogeneous group of rare malignancies of mesenchymal origin including more than 70 subtypes. They may arise in muscle, bone, cartilage and other connective tissues. Their high histological and genetic heterogeneity makes diagnosis and treatment very challenging. Read More

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http://dx.doi.org/10.1007/978-3-030-34521-1_15DOI Listing
January 2020

Establishment and characterization of NCC-SS3-C1: a novel patient-derived cell line of synovial sarcoma.

Hum Cell 2020 Apr 9. Epub 2020 Apr 9.

Division of Rare Cancer Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Synovial sarcoma is a rare malignancy of mesenchymal origin, characterized by a chromosomal translocation, t(X;18) (p11.2;q11.2). Read More

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http://dx.doi.org/10.1007/s13577-020-00354-6DOI Listing

Battle Against Musculoskeletal Tumors: Descriptive Data of Military Hospital Experience.

Front Public Health 2020 25;8:97. Epub 2020 Mar 25.

Department of Orthopaedics and Traumatology, Gulhane Training and Research Hospital, Ankara, Turkey.

Management of musculoskeletal tumors remains challenging for orthopedic surgeons. The aim of this cross-sectional study was to present the prevalence and localization of musculoskeletal disorders diagnosed and treated at a tertiary referral military hospital. A total of 552 patients' medical records who presented to our clinic between 2009 and 2014 with the diagnosis of musculoskeletal tumors were retrospectively analyzed according to age, gender, bone/soft tissue localization, histopathological diagnosis, incidence, and treatment. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109251PMC

Histiocyte predominant myocarditis resulting from the addition of interferon gamma to cyclophosphamide-based lymphodepletion for adoptive cellular therapy.

J Immunother Cancer 2020 Apr;8(1)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Background: Adoptive cellular therapy (ACT) is a promising treatment for synovial sarcoma (SS) with reported response rates of over 50%. However, more work is needed to obtain deeper and more durable responses. SS has a 'cold' tumor immune microenvironment with low levels of major histocompatibility complex (MHC) expression and few T-cell infiltrates, which could represent a barrier toward successful treatment with ACT. Read More

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http://dx.doi.org/10.1136/jitc-2019-000247DOI Listing

Primary advanced pulmonary synovial sarcoma treated with a multidisciplinary approach.

Int Cancer Conf J 2020 Apr 14;9(2):72-76. Epub 2020 Feb 14.

Department of Respiratory Medicine, Hiroshima City Asa Citizens Hospital, 2-1-1 Kabe-Minami, Asa-kita-ku, Hiroshima, 731-0293 Japan.

A 61-year-old woman was referred to our hospital due to right chest pain. A huge, 13-cm-diameter tumor was detected in the right lower lobe. For diagnostic and treatment purposes, pneumonectomy was performed, and the tumor was diagnosed as advanced pulmonary synovial sarcoma (SS) with pleural metastasis, according to immunohistochemistry analysis. Read More

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http://dx.doi.org/10.1007/s13691-020-00399-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109214PMC

Birth Characteristics and Risk of Early-Onset Synovial Sarcoma.

Cancer Epidemiol Biomarkers Prev 2020 Apr 3. Epub 2020 Apr 3.

Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.

Background: Synovial sarcoma is a rare cancer with peak incidence in the young adult period. Despite poor outcomes of this aggressive cancer, there is little epidemiologic research addressing its etiology.

Methods: We collected birth characteristic data on synovial sarcoma cases born during 1978-2015 and diagnosed during 1988-2015 in California ( = 244), and 12,200 controls frequency-matched on year of birth. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-20-0093DOI Listing

Shoulder Tumor/Tumor-Like Lesions: What to Look for.

Magn Reson Imaging Clin N Am 2020 May;28(2):301-316

Department of Radiology, University of California San Diego, School of Medicine, UCSD Teleradiology and Education Center, 408 Dickinson Street, Mail Code #8226, San Diego, CA 92103-8226, USA.

This article discusses the most common tumor and tumor-like lesions arising at the shoulder. Osseous tumors of the shoulder rank second in incidence to those at the knee joint and include benign osteochondromas and myeloma or primary malignant lesions, such as osteosarcoma or chondrosarcomas. Soft tissue tumors are overwhelmingly benign, with lipomas predominating, although malignant lesions, such as liposarcomas, can occur. Read More

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http://dx.doi.org/10.1016/j.mric.2019.12.011DOI Listing

BRAF V600E mutation is a potential therapeutic target for a small subset of synovial sarcoma.

Mod Pathol 2020 Apr 1. Epub 2020 Apr 1.

Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.

Synovial sarcoma (SS) is an aggressive tumor that most often affects the deep soft tissues in young adults. Intrathoracic SS is rare and is associated with poor outcome, highlighting the urgent need for a novel therapeutic strategy. In the process of clinical sequencing, we identified two patients with intrathoracic SS harboring the BRAF V600E mutation. Read More

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http://dx.doi.org/10.1038/s41379-020-0530-3DOI Listing

A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas.

Cancer Immunol Immunother 2020 Mar 28. Epub 2020 Mar 28.

Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich, Thalkirchner Str. 36, 80337, Munich, Germany.

Soft tissue sarcomas (STSs) are heterogeneous cancers associated with poor prognosis due to high rates of local recurrence and metastasis. The programmed death receptor ligand 1 (PD-L1) is expressed in several cancers. PD-L1 interacts with its receptor, PD-1, on the surface of tumor-infiltrating lymphocytes (TILs), thereby attenuating anti-cancer immune response. Read More

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http://dx.doi.org/10.1007/s00262-020-02552-5DOI Listing

Time lapse analysis of tumor response in patients with soft tissue sarcoma treated with trabectedin: A pooled analysis of two phase II clinical trials.

Cancer Med 2020 Mar 27. Epub 2020 Mar 27.

Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo, Japan.

The time course of the response to each drug is important to avoid inappropriate termination of treatment by misjudging tumor progression; however, little is known about soft tissue sarcoma (STS) regarding this matter. This study aimed to perform a time-lapse analysis of tumor response in patients with STS treated with trabectedin from 2 phase II clinical trials. We examined 66 patients with translocation-related sarcoma registered in 2 Japanese phase II clinical trials. Read More

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http://dx.doi.org/10.1002/cam4.2991DOI Listing

The Value of H3K27me3 Immunohistochemistry in Differentiating Malignant Peripheral Nerve Sheath Tumour with Its Histologic Mimickers.

Asian Pac J Cancer Prev 2020 Mar 1;21(3):699-705. Epub 2020 Mar 1.

Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.

Background: Diagnosis of malignant peripheral nerve sheath tumor (MPNST) is rather challenging due to its divergent morphologic heterogeneity and lack of specific ancillary test. The emergence of H3K27 trimethylation (H3K27me3) as a new immunohistochemistry (IHC) marker for MPNST have recently available to assist pathologists in differentiating MPNST from other histologic mimics. We aim to study the expression pattern of H3K27me3 in MPNST and its histologic mimickers and their association with the clinicopathological data. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.3.699DOI Listing

Impact of the Activation Status of the Akt/mTOR Signalling Pathway on the Clinical Behaviour of Synovial Sarcoma: Retrospective Analysis of 174 Patients at a Single Institution.

Cancer Manag Res 2020 9;12:1759-1769. Epub 2020 Mar 9.

Department of Pathology, Medical School of Chinese People's Liberation Army, Beijing 100853, People's Republic of China.

Purpose: Phosphoinositide 3-kinase (PI3K) and the downstream Akt/mammalian target of rapamycin (mTOR) pathway are central to the control of cell proliferation and survival. Although abnormal activation of this pathway has been well established in a variety of tumours, limited studies are available on synovial sarcoma. The aim of this study was to investigate the expression of several key proteins of those pathways in synovial sarcomas and to correlate the expression of these proteins with clinicopathologic features and prognosis. Read More

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http://dx.doi.org/10.2147/CMAR.S228578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074818PMC

Unusual Mimicker of the Carotid Body Tumor: Synovial Sarcoma of the Carotid Space.

J Craniofac Surg 2020 Mar 19. Epub 2020 Mar 19.

Department of Radiology, Ataturk University School of Medicine, Erzurum Turkey.

Synovial cell sarcomas are malignant tumors originating from pluripotent mesenchymal stem cells, unlike its name. It is a common tumor in the periarticular area, accounting for 8% of all soft tissue sarcomas. Head and neck are among the rarest areas of this tumor. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006365DOI Listing

Paediatric Renal Synovial Sarcoma: Another Diagnostic Pathological Dilemma.

Indian J Surg Oncol 2020 Mar 27;11(1):138-141. Epub 2019 Oct 27.

3Department of Pathology, Christian Medical College, Vellore, India.

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http://dx.doi.org/10.1007/s13193-019-00989-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064649PMC

Calcium-Dependent Calpain Activation-Mediated Mitochondrial Dysfunction and Oxidative Stress Are Required for Cytotoxicity of Epinecidin-1 in Human Synovial Sarcoma SW982 Cells.

Int J Mol Sci 2020 Mar 19;21(6). Epub 2020 Mar 19.

Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, 23-10 Dahuen Road, Jiaushi, Ilan 262204, Taiwan.

Synovial sarcoma is a rare but highly malignant and metastatic disease. Despite its relative sensitivity to chemotherapies, the high recurrence and low 5-year survival rate for this disease suggest that new effective therapeutic agents are urgently needed. Marine antimicrobial peptide epinecidin-1 (epi-1), which was identified from orange-spotted grouper (), exhibits multiple biological effects, including bactericidal, immunomodulatory, and anticancer activities. Read More

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http://dx.doi.org/10.3390/ijms21062109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139453PMC

Delayed diagnosis of Ewing's sarcoma in a young patient presented with left knee monoarthritis.

BMJ Case Rep 2020 Mar 19;13(3). Epub 2020 Mar 19.

Gastroenterology Unit, Department of Internal Medicine, Hospital Sultanah Bahiyah, Alor Setar, Kedah Darul Aman, Malaysia.

A 19-year-old girl presented to the rheumatology clinic for left knee monoarthritis for the past 4 months. She also had constitutional symptoms with significant weight loss. On physical examination, she appeared cachexic, her left knee was swollen and tender. Read More

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http://dx.doi.org/10.1136/bcr-2019-232193DOI Listing

Malignant synovial sarcoma: An unpredictable cause of brachial plexopathy.

Clin Neurol Neurosurg 2020 Jun 2;193:105767. Epub 2020 Mar 2.

Department of Neurology, Institute of Human Behavior and Allied Sciences, New Delhi, India.

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http://dx.doi.org/10.1016/j.clineuro.2020.105767DOI Listing

Synovial Sarcoma: A Series of Small Tumors in Active Duty Service Members.

Mil Med 2020 Mar 20. Epub 2020 Mar 20.

Department of Orthopaedic Surgery, San Antonio Military Medical Center, JBSA-Fort Sam Houston, San Antonio Military Medical Center, 3551 Roger Brooke Drive, Ft. Sam Houston TX, 78219.

Synovial Sarcoma is a soft tissue sarcoma with a propensity to imitate a benign neoplasm. It is most common in males 15-40 years old, typically presents as a slow growing painful mass, and often arises insidiously without alarm to the patient. Three patients with synovial sarcomas who had each undergone an index procedure to treat a small presumedly benign mass that was later identified as synovial sarcoma were reviewed. Read More

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http://dx.doi.org/10.1093/milmed/usaa048DOI Listing

Prominent entrapment of respiratory epithelium in primary and metastatic intrapulmonary non-epithelial neoplasms: a frequent morphological pattern closely mimicking adenofibroma and other biphasic pulmonary lesions.

Virchows Arch 2020 Mar 19. Epub 2020 Mar 19.

Institute of Pathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital, Krankenhausstrasse 8-10, 91054, Erlangen, Germany.

As one of the most common target organs for hematogenous spread from diverse cancers, biopsy interpretation of lung tumors is complicated by the challenging question of primary versus metastatic and by frequent entrapment of native respiratory glands. Nevertheless, the literature dealing with this issue is surprisingly sparse and no single study has been devoted to this topic. We reviewed 47 surgical lung specimens of non-epithelial neoplasms (38 metastases, mainly from sarcomas and 9 primary lesions) for frequency and pattern of intralesional epithelial entrapment. Read More

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http://dx.doi.org/10.1007/s00428-020-02796-7DOI Listing

Clinical features and outcomes of primary bone and soft tissue sarcomas in adolescents and young adults.

Mol Clin Oncol 2020 Apr 4;12(4):358-364. Epub 2020 Feb 4.

Department of Orthopaedic Surgery, Kindai University Hospital, Osaka-Sayama, Osaka 589-8511, Japan.

The aim of the present study was to investigate the clinical outcomes of adolescents and young adults with bone and soft tissue sarcomas. Records of seven male and six female patients aged 17-39 years with bone or soft tissue sarcomas were reviewed retrospectively; data on histology, size, location, grade/stage, treatment, recurrence, presence of metastasis, and prognosis were retrieved. Five-year survival rates were estimated using the Kaplan-Meier method and were compared according to age, sarcoma type, histological grade, and location. Read More

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http://dx.doi.org/10.3892/mco.2020.1994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058051PMC

[Synovial sarcoma of the abdominal wall with rhabdoid features: report of a case].

Zhonghua Bing Li Xue Za Zhi 2020 Mar;49(3):274-276

Department of Pathology, the People's Hospital of Jiangsu Province (The First Affiliated Hospital with Nanjing Medical University), Nanjing 210029, China.

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2020.03.014DOI Listing

Systemic therapy in pediatric-type soft-tissue sarcoma.

Curr Oncol 2020 Feb 1;27(Suppl 1):6-16. Epub 2020 Feb 1.

Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON.

Soft-tissue sarcoma (sts) is rare and represents approximately 7% of cancers in children and in adolescents less than 20 years of age. Rhabdomyosarcoma (rms) is most prevalent in children less than 10 years of age and peaks again during adolescence (16-19 years of age). Multi-agent chemotherapy constitutes the mainstay of treatment for rms. Read More

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http://dx.doi.org/10.3747/co.27.5481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050042PMC
February 2020

A case of primary pleural synovial sarcoma with endobronchial recurrence.

Respirol Case Rep 2020 Apr 5;8(3):e00547. Epub 2020 Mar 5.

Department of Respiratory Hospital Raja Permaisuri Bainun Ipoh Malaysia.

Primary pleural synovial sarcoma (PPSS) is an extremely rare malignancy without a known cause. The diagnosis is made after excluding metastasis from an extra-thoracic sarcoma. We report a case of a 67-year-old gentleman who presented with an incidental finding of a left lung mass on a routine chest X-ray. Read More

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http://dx.doi.org/10.1002/rcr2.547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057028PMC

Fine-needle aspiration cytology of primary mediastinal synovial sarcoma: A case report with an immunocytochemical approach.

Diagn Cytopathol 2020 May 10;48(5):499-501. Epub 2020 Mar 10.

Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka, Japan.

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http://dx.doi.org/10.1002/dc.24407DOI Listing

Surgery and Proton Beam Therapy for Tracheal Synovial Sarcoma.

Ann Thorac Surg 2020 Mar 4. Epub 2020 Mar 4.

Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:

Synovial sarcoma (SS) is an uncommon malignant tumor associated with poor prognosis, and SS arising from the trachea is even rare with only three cases reported before. We present the case of a 19-year-old male and the imaging studies revealed a mass of soft tissue density in the lower trachea. An en bloc trachea segmental resection and post-operative proton beam therapy were performed. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.01.058DOI Listing

A Novel SS18-SSX Fusion-specific Antibody for the Diagnosis of Synovial Sarcoma.

Am J Surg Pathol 2020 Mar 3. Epub 2020 Mar 3.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School.

Synovial sarcoma (SS), an aggressive soft tissue sarcoma with a predilection for the extremities of young adults, harbors the pathognomonic t(X;18)(p11;q11) translocation, resulting in SS18-SSX rearrangements. SS includes monophasic, biphasic, and poorly differentiated variants, which show considerable histologic overlap with a range of other tumor types, making the diagnosis challenging on limited biopsies. Immunohistochemistry (IHC) is routinely used in the differential diagnosis; however, presently available markers lack specificity. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001447DOI Listing

Metastatic de-differentiated melanoma resembling synovial sarcoma diagnosed by synchronous NRAS genetic mutation.

ANZ J Surg 2020 Mar 6. Epub 2020 Mar 6.

Anatomical Pathology, MedLab Pathology, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1111/ans.15797DOI Listing