5,108 results match your criteria Synovial Sarcoma


Sarcomas with Sclerotic Epithelioid Phenotype Harboring Novel EWSR1-SSX1 Fusions.

Genes Chromosomes Cancer 2021 May 14. Epub 2021 May 14.

Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Undifferentiated sarcomas remain difficult to classify. Despite the remarkable advances in sarcoma classification made by the increased application of RNA sequencing in clinical practice, the unexpected result of a novel gene fusion raises further questions regarding the tumor histogenesis and subclassification. In this study we present 2 high grade sarcomas with epithelioid phenotype occurring in the deep-soft tissues (shoulder, thigh) of young adults which based on the non-specific pathologic findings were deemed unclassified and subjected to targeted RNA sequencing for further diagnostic interpretation. Read More

View Article and Full-Text PDF

ETV4/5 drive synovial sarcoma through control of the cell cycle and the DUX4 embryonic pathway.

J Clin Invest 2021 May 13. Epub 2021 May 13.

Department of Medicine, Division of Medical Oncology, University of Miami Miller School of Medicine, Miami, United States of America.

Synovial sarcoma is an aggressive malignancy with no effective treatments for patients with metastasis. The synovial sarcoma fusion, SS18-SSX, which recruits the SWI/SNF-BAF chromatin remodeling and polycomb repressive complexes, results in epigenetic activation of FGFR signaling. In genetic FGFR knockout models, culture, and xenograft synovial sarcoma models treated with the FGFR inhibitor BGJ398, we show that FGFR1, FGFR2, and FGFR3 were crucial for tumor growth. Read More

View Article and Full-Text PDF

Right atrial synovial sarcoma with thrombocytopenia: A deceptive presentation.

J Card Surg 2021 May 12. Epub 2021 May 12.

Department of Cardiac Surgery, CIMS Hospital, Ahmedabad, Gujarat, India.

Introduction: Primary cardiac synovial sarcoma is an exceedingly rare soft tissue malignant tumor, involving either the pericardium or chambers, with a striking male predominance, prevalently seen in the fourth decade. These tumours most commonly present as breathlessness on exertion. These patients readily exhibit gastrointestinal and systemic symptoms but sometimes the presentation can be fallacious. Read More

View Article and Full-Text PDF

Pediatric Head and Neck Tumors Associated with Li-Fraumeni Syndrome.

Ann Otol Rhinol Laryngol 2021 May 10:34894211014786. Epub 2021 May 10.

Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.

Introduction: Cancer predisposition syndromes are germline pathogenic variants in genes that greatly raise the risk of developing neoplastic diseases. One of the most well-known is Li-Fraumeni syndrome (LFS), which is due to pathogenic variants in the gene. Children with LFS have higher risks for multiple malignancies before adulthood, often with rare and aggressive subtypes. Read More

View Article and Full-Text PDF

SSX C-Terminus is a Useful Diagnostic Biomarker for Spermatocytic Tumour.

Histopathology 2021 May 7. Epub 2021 May 7.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Aims: Spermatocytic tumour (ST) is a rare testicular germ cell neoplasm that can be challenging to diagnose and for which there are few confirmatory biomarkers. Like normal spermatogonia, STs are known to express SSX proteins. Recently, a novel SSX antibody directed against the C-terminus (SSX_CT) of SSX1, SSX2 and SSX4, has emerged as a reliable biomarker for these SSX proteins and synovial sarcoma. Read More

View Article and Full-Text PDF

IL-15 mediated expansion of rare durable memory T cells following adoptive cellular therapy.

J Immunother Cancer 2021 May;9(5)

Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA, USA

Background: Synovial sarcoma (SS) and myxoid/round cell liposarcoma (MRCL) are ideal solid tumors for the development of adoptive cellular therapy (ACT) targeting NY-ESO-1, as a high frequency of tumors homogeneously express this cancer-testes antigen. Data from early phase clinical trials have shown antitumor activity after the adoptive transfer of NY-ESO-1-specific T cells. In these studies, persistence of NY-ESO-1 specific T cells is highly correlated with response to ACT, but patients often continue to have detectable transferred cells in their peripheral blood following progression. Read More

View Article and Full-Text PDF

Neck exploration for a huge synovial sarcoma, case report and literature review.

J Pak Med Assoc 2021 Feb;71(2(B)):766-768

Department of Surgery, Mayo Hospital, Lahore, Pakistan.

A 47-year-old woman presented in the outpatient department of EAST Surgical ward of MAYO Hospital Lahore, Pakistan, on February 2019 with complaint of swelling in the front section of the neck since five months which increased gradually in size and had been causing pain since two months. She had no comorbidities and insignificant family history. Examination revealed a 23×20 cm mass on the right side of the posterior triangle of the neck. Read More

View Article and Full-Text PDF
February 2021

Synovial Sarcoma of the Hand and Foot: An Institutional Review.

Am J Clin Oncol 2021 Apr 29. Epub 2021 Apr 29.

Departments of Sarcoma Medical Oncology Radiation Oncology Orthopaedic Oncology Pathology Genomic Medicine, The University of Texas MD Anderson Cancer Center Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center Department of Pediatrics, Baylor College of Medicine, Houston, TX.

Objectives: Synovial sarcomas (SS) arising in distal extremities are rare and have been studied using mostly case reports and small series. We aimed to evaluate clinical presentation and survival outcomes for patients with hand or foot SS.

Materials And Methods: We conducted a retrospective review of 84 patients diagnosed with primary hand (n=20) and foot (n=64) SS between 1979 and 2019. Read More

View Article and Full-Text PDF

Liquid Biopsy Targeting Monocarboxylate Transporter 1 on the Surface Membrane of Tumor-Derived Extracellular Vesicles from Synovial Sarcoma.

Cancers (Basel) 2021 Apr 11;13(8). Epub 2021 Apr 11.

Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan.

The lack of noninvasive biomarkers that can be used for tumor monitoring is a major problem for soft-tissue sarcomas. Here we describe a sensitive analytical technique for tumor monitoring by detecting circulating extracellular vesicles (EVs) of patients with synovial sarcoma (SS). The proteomic analysis of purified EVs from SYO-1, HS-SY-II, and YaFuSS identified 199 common proteins. Read More

View Article and Full-Text PDF

Cellular Radiosensitivity of Soft Tissue Sarcoma.

Radiat Res 2021 Apr 29. Epub 2021 Apr 29.

Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Currently, all soft tissue sarcomas (STS) are irradiated by the same regimen, disregarding possible subtype-specific radiosensitivities. To gain further insight, cellular radiosensitivity was investigated in a panel of sarcoma cell lines. Fourteen sarcoma cell lines, derived from synovial sarcoma, leiomyosarcoma, fibrosarcoma and liposarcoma origin, were submitted to clonogenic survival assays. Read More

View Article and Full-Text PDF

Reconstruction of the elbow using pedicle joint freezing after wide excision for soft tissue sarcoma: A case report.

Mol Clin Oncol 2021 Jun 8;14(6):115. Epub 2021 Apr 8.

Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903-0125, Japan.

A 35-year-old man presented with a four-year history of a growing mass on the anterior aspect of his left elbow. Magnetic resonance imaging revealed a soft tissue tumor in the brachialis muscle extending to the cubital fossa. Following an open biopsy, the tumor was diagnosed as a monophasic fibrous synovial sarcoma. Read More

View Article and Full-Text PDF

Synovial sarcoma of the spinal canal and paraspinal muscle and retroperitoneum: a case with extensive calcification.

Childs Nerv Syst 2021 Apr 24. Epub 2021 Apr 24.

Department of Radiology, Chengcheng County Hospital, North side of Qingnian Road, Chengcheng, 715200, Shaanxi Province, China.

Introduction: Synovial sarcoma (SS) is a rare mesenchymal malignant tumor. SS of the spine or retroperitoneum is an extremely rare site. Approximately 30% cases show focal calcifications on radiographs and computed tomography (CT) images, while extensive calcification rarely occurs. Read More

View Article and Full-Text PDF

Proteomic profiling of soft tissue sarcomas with SWATH mass spectrometry.

J Proteomics 2021 Jun 22;241:104236. Epub 2021 Apr 22.

Division of Molecular Pathology, The Institute of Cancer Research, 237 Fulham Road, SW3 6JB London, UK. Electronic address:

Soft tissue sarcomas (STS) are a group of rare and heterogeneous cancers. While large-scale genomic and epigenomic profiling of STS have been undertaken, proteomic analysis has thus far been limited. Here we utilise sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS) for proteomic profiling of formalin fixed paraffin embedded (FFPE) specimens from a cohort of STS patients (n = 36) across four histological subtypes (leiomyosarcoma, synovial sarcoma, undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma). Read More

View Article and Full-Text PDF

Synovial Sarcoma Oncogenesis Revealed by Single-Cell Profiling.

Trends Cancer 2021 Apr 20. Epub 2021 Apr 20.

Faculty of Medicine, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Synovial sarcoma is a soft tissue malignancy driven by the SS18-SSX fusion oncoprotein. In Nature Medicine, Jerby-Arnon et al. present a single-cell dataset for synovial sarcoma that reveals a novel 'core oncogenic program' driven by SS18-SSX, with implications for treatment strategies based on epigenetics, cell-cycle control, and immune augmentation. Read More

View Article and Full-Text PDF

Forequarter amputation post transarterial chemoembolization and radiation in synovial sarcoma: A case report.

Int J Surg Case Rep 2021 Apr 23;81:105824. Epub 2021 Mar 23.

Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia.

Introduction And Importance: Forequarter amputation or interscapulathoracalis amputation is a major amputation procedure that involves the entire upper extremity, scapula, and a whole or part of the clavicula. Forequarter amputation is commonly used to control bleeding in malignant tumor cases in which no treatment is available for the extremities.

Case Presentation: We report a case of forequarter amputation in a 25-year-old patient with synovial sarcoma. Read More

View Article and Full-Text PDF

DNA methylation profiling discriminates between malignant pleural mesothelioma and neoplastic or reactive histological mimics.

J Mol Diagn 2021 Apr 19. Epub 2021 Apr 19.

Department of Neuropathology, Institute of Pathology, University Hospital of Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.

Diagnosis of malignant pleural mesothelioma (MPM) is a challenging task because of its potential overlap with other neoplasms or even with reactive conditions. Recently, DNA methylation analysis proved to be an effective tool for tumor diagnosis. In the present study, this approach was tested for MPM diagnosis. Read More

View Article and Full-Text PDF

The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.

Diagn Pathol 2021 Apr 20;16(1):32. Epub 2021 Apr 20.

Emeritus Professor, Kyung Hee University, School of Medicine Vice President of Asia, International Academy of Pathology, U2Labs, Jangwon Medical Foundation 68 Geoma-ro, Songpa-gu, Seoul, 05755, South Korea.

Background: Solitary Fibrous Tumor (SFT) is a distinct soft tissue neoplasm associated with NAB2-STAT6 gene fusion. It can involve a number of anatomic sites and exhibits a wide spectrum of histological features.

Main Body: Apart from diversity in morphological features seen even in conventional SFT, two histologic variants (fat-forming and giant cell-rich) are also recognized. Read More

View Article and Full-Text PDF

Long non-coding RNA HOTAIR promotes the progression of synovial sarcoma through microRNA-126/stromal cell-derived factor-1 regulation.

Oncol Lett 2021 Jun 6;21(6):444. Epub 2021 Apr 6.

Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.

The long non-coding RNA (lncRNA) HOTAIR is an oncogene, that has been reported to be aberrantly expressed in multiple types of malignant tumor tissues. However, its expression and association with synovial sarcoma (SS) remains unclear. The present study aimed to elucidate the expression level of HOTAIR in SS tissues and also identify its role. Read More

View Article and Full-Text PDF

Localized pleural metastasis without other organ metastases after nephrectomy for renal cell carcinoma.

Respir Med Case Rep 2021 19;33:101388. Epub 2021 Mar 19.

Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

We present a case of a 69-year-old man who had localized pleural metastasis without other organ metastases after nephrectomy for right renal cell carcinoma (RCC). He complained of respiratory symptoms for more than two years after the operation and was confirmed to have right pleural effusion and multiple pleural masses on computed tomography (CT). There were no abnormal findings in the other organs, but the pleural mass gradually increased in size on CT. Read More

View Article and Full-Text PDF

Tissue microarray based immunohistochemical study of TLE1 in synovial sarcoma and its histologic mimics.

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):310-315

Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad; Department of Pathology and Lab Medicine, Basavatharakam Indoamerican Cancer Hospital and Research Institute, Hyderabad, Telangana, India.

Background And Aims: Molecular analysis is gold standard for diagnosis of synovial sarcoma (SS) but use of these ancillary techniques is limited by many practical issues like cost and limited resources. Several studies analyzed TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma and few studies disagreed. The objective of the study was to evaluate immunohistochemical expression of TLE1 in synovial sarcoma and its histological mimics. Read More

View Article and Full-Text PDF

The role of SYT-SSX fusion gene in tumorigenesis of synovial sarcoma.

Pathol Res Pract 2021 Mar 24;222:153416. Epub 2021 Mar 24.

Department of Pathology, Shihezi University School of Medicine & the First Affiliated Hospital to Shihezi University School of Medicine, Shihezi, 832002, Xinjiang, China; Department of Pathology, Central People's Hospital of Zhanjiang and Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, China. Electronic address:

Synovial sarcoma (SS) is an aggressive malignancy of an unknown tissue origin that is characterized by biphasic differentiation. A possible basis of the pathogenesis of SS is pathognomonic t(X;18) (p11.2; q11. Read More

View Article and Full-Text PDF

Synovial sarcoma of the stomach: a case report and a systematic review of literature.

Clin J Gastroenterol 2021 Apr 12. Epub 2021 Apr 12.

Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

Worldwide, 5-10% of soft tissue sarcoma cases in adults have been attributed to synovial sarcoma. It is often reported to occur near the joints of the arm, neck, and leg but rarely in the gastrointestinal tract. In this study, we report a case of synovial sarcoma arising in the stomach of a 59-year-old woman. Read More

View Article and Full-Text PDF

Echo(e)s of an invasion: a rare pericardial synovial sarcoma.

Hellenic J Cardiol 2021 Apr 8. Epub 2021 Apr 8.

Third Cardiology Department, Hippokrateion University Hospital, Medical School, Aristotle University Thessaloniki, Thessaloniki, Greece.

View Article and Full-Text PDF

Pediatric solid intra-articular masses of the knee: prevalence, imaging features and etiologies.

Pediatr Radiol 2021 Apr 9. Epub 2021 Apr 9.

Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 225 E. Chicago Ave., Chicago, IL, 60611, USA.

Background: The etiologies of pediatric solid intra-articular soft-tissue masses are not well described and can present diagnostic dilemmas.

Objective: Our hypothesis was that these entities have a limited differential diagnosis and are mostly benign.

Materials And Methods: We reviewed knee magnetic resonance imaging (MRI) scans performed at our tertiary care institution between 2001 and 2019 (n=3,915). Read More

View Article and Full-Text PDF

How Can a Multidisciplinary Approach Improve Prognosis of Soft-Tissue Sarcomas of Extremities?

Int J Surg Oncol 2021 24;2021:8871557. Epub 2021 Mar 24.

Department of Pathology, Hassan II University Hospital, Fez, Morocco.

Soft-tissue sarcomas are malignant tumors that require good management within specialized centers. Our study aims to assess the benefit of handling these kinds of tumors using the Multidisciplinary Meeting (MDM) approach. The current paper details this approach through a prospective study that has lasted for 42 months in the HASSAN II University Hospital Center, Fez, Morocco. Read More

View Article and Full-Text PDF

Is perioperative chemotherapy recommended in childhood and adolescent patients with synovial sarcoma? A systematic review.

Jpn J Clin Oncol 2021 Apr 6. Epub 2021 Apr 6.

Department of Musculoskeletal Oncology, National Cancer Center Hospital Tokyo, Japan.

Objective: Synovial sarcoma is the most common soft tissue sarcomas among childhood and adolescents, accounting for 8-10% of all soft tissue sarcoma. Synovial sarcoma is considered a relatively chemosensitive tumor compared with other soft tissue sarcomas. However, the role of perioperative chemotherapy in synovial sarcoma remains controversial. Read More

View Article and Full-Text PDF

Synovial sarcoma with overwhelming glandular (adenocarcinoma-like) component: A case report and review of the literature.

Pathol Res Pract 2021 Mar 27;222:153418. Epub 2021 Mar 27.

Department of Pathology, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, 251 East Huron St, Feinberg 7-342A, Chicago, IL 60611, United States.

Synovial sarcoma is an uncommon tumor of soft tissue, characterized by a specific SS18-SSX1/2/4 fusion gene. It is generally a lesion composed of monomorphic spindle cells, and can sometimes show variable epithelial differentiation. Here, we present the case of a young woman with a synovial sarcoma of the abdominal wall that showed an overwhelming (>90 %) epithelial glandular component mimicking adenocarcinoma, and only rare spindled areas. Read More

View Article and Full-Text PDF

Correlation between Tumour Associated Macrophage (TAM) Infiltration and Mitotic Activity in Canine Soft Tissue Sarcomas.

Animals (Basel) 2021 Mar 4;11(3). Epub 2021 Mar 4.

Department of Veterinary Anatomy Physiology and Pathology, Institute of Infection, Veterinary and Ecological Science, Neston CH64 7TE, UK.

Tumour-associated macrophages (TAMs) are an important part of the tumour microenvironment but knowledge of their distribution in canine soft tissue sarcomas (STSs) is limited to absent. We analysed 38 STSs retrieved from the veterinary pathology archive; oral and visceral STSs, synovial cell sarcoma, tumours of histiocytic origin, haemangiosarcoma, carcinosarcomas, and undifferentiated tumours were excluded. Iba-1 positive, non-neoplastic tumour infiltrating cells (morphologically indicative of macrophages) were classified as TAMs and were counted in 10 consecutive tumours areas, where no necrosis or other inflammatory cells could be identified. Read More

View Article and Full-Text PDF

[Analysis of efficacy of coblation assisted endoscope system for the treatment of parapharyngeal space tumors with transoral approach].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Mar;35(3):204-208

Department of Otorhinolaryngology,the First Affiliated Hospital,Nanjing Medical University,Nanjing,210029,China.

To summarize and analyze the feasibility, safety and efficacy of parapharyngeal space surgery assisted by coblation and endoscopic system with transoral approach. The data of 20 patients with parapharyngeal space tumors were retrospectively analyzed. All the patients underwent CT and/or MRI examination before surgery, and all underwent transoral approach assisted by coblation and endoscopic systems. Read More

View Article and Full-Text PDF

Primary synovial sarcoma of the mediastinum: a rare tumor diagnosed by endoscopic ultrasound-fine needle biopsy (EUS-FNB)-Cytomorphologic, immunohistochemical, and molecular analysis.

Clin J Gastroenterol 2021 Apr 1. Epub 2021 Apr 1.

Department of Pathology, Rambam Health Care Campus, Haifa, Israel.

Primary synovial sarcoma is exceedingly rare in the mediastinum. The differential diagnosis of this rare tumor is complex as a wide array of primary and metastatic tumors occur in this site.A definite diagnosis might be challenging even after tissue sampling. Read More

View Article and Full-Text PDF