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Turk Neurosurg 2021 Dec 22. Epub 2021 Dec 22.

Umraniye Education and Research Hospital, Department of Pathology, Istanbul, Turkey.

Aim: The spinal canal frequently harbors primary and secondary bone tumors. These tumors have specific localization, age range, and clinical and radiological manifestations, and their treatment requires a multidisciplinary approach. In most cases, a definitive diagnosis is made based on clinical, radiological, and histopathological findings. Read More

Clin Rheumatol 2022 May 31. Epub 2022 May 31.

Division of Rheumatology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Synovial osteochondromatosis is an extremely rare benign condition in children and adolescents that have joint pain as a presenting manifestation. It is usually monoarticular with the knee as the most common affected joint. In this article, we describe the case of a female adolescent suffering from debilitating chronic right knee pain initially mimicking juvenile idiopathic arthritis, who was subsequently diagnosed with primary synovial osteochondromatosis. Read More

Int J Surg Case Rep 2022 Jun 4;95:107149. Epub 2022 May 4.

Department of Orthopaedic Surgery, King Fahad Hufof Hospital, Hofuf, Saudi Arabia.

Introduction: Synovial chondromatosis (SC) is a benign metaplastic proliferation of cartilaginous nodules within the synovial membrane that commonly manifests as "loose masses" in the joint space. Synovial chondromatosis affects 1.8 per 1 million individuals. Read More

JNMA J Nepal Med Assoc 2022 May 5;60(249):478-481. Epub 2022 May 5.

Department of Orthopaedics and Trauma Surgery, Scheer Memorial Adventist Hospital, Banepa, Kavre, Nepal.

Synovial chondromatosis in association with ankylosing spondylitis is extremely rare and has been reported only once before and this case report is presenting a similar case. The knee is the preferential site of involvement with involvement of the hip being reported sparsely. We herein report a case of a 52-year-old male who came with complaints of the lower back pain for 5 years and left hip pain for 1. Read More

J Radiol Case Rep 2021 Aug 1;15(8):8-17. Epub 2021 Aug 1.

Department of Radiology, Nassau University Medical Center, East Meadow, NY, USA.

Tenosynovial chondromatosis is a rare benign disorder characterized by formation of cartilaginous bodies within the synovia of the tendon sheaths. Most commonly present in the hands and feet. Clinical presentation and plain radiography can be inconclusive, which can lead to misclassification, most often confused as a chondroma of soft parts. Read More

Magn Reson Imaging Clin N Am 2022 May 13;30(2):339-350. Epub 2022 Apr 13.

Department of Radiology, UCSD Health System, University of California, HCOP MRI, 408 Dickinson Street, San Diego, CA 92103-8226, USA.

Intra-articular masses affecting the knee joint are uncommon lesions that encompass a range of neoplastic and nonneoplastic disorders. A joint mass limited to a single articulation is most commonly related to neoplastic or focal proliferative disease, whereas masses affecting multiple articulations are typically caused by underlying inflammatory arthritides, metabolic abnormalities, or systemic deposition disorders. This article focuses on those masses that present in a monoarticular fashion, emphasizing the lesions that most commonly affect the knee joint. Read More

J Wrist Surg 2022 Apr 24;11(2):177-180. Epub 2021 Mar 24.

Department of Orthopaedic Surgery, UZ Leuven, Leuven, Belgium.

 Synovial chondromatosis is a rare benign proliferative disorder of synovium characterized by the formation of cartilaginous bodies in a joint. The condition typically affects one single large joint. The development of synovial chondromatosis in the joints of hand and wrist is extremely rare. Read More

Skeletal Radiol 2022 Apr 25. Epub 2022 Apr 25.

Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, 1400 VFW Parkway, Suite 1B105, West Roxbury, Boston, MA, 02132, USA.

Int J Environ Res Public Health 2022 04 13;19(8). Epub 2022 Apr 13.

Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.

Synovial chondromatosis (SC) is a rare benign disease involving multifocal generation of ectopic cartilage in the synovial tissue. Herein, we report two cases of SC in the temporomandibular joint: a 38-year-old woman (patient 1) and 39-year-old woman (patient 2). Both patients had trismus, jaw joint noises, and jaw-opening pain in the temporomandibular joint. Read More

Skeletal Radiol 2022 Apr 13. Epub 2022 Apr 13.

Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, 1400 VFW Parkway, Suite 1B105, West Roxbury, Boston, MA, 02132, USA.

Intra-articular masses are not a rare finding in routine imaging. This is particularly true in patients with underlying joint diseases such as degenerative arthritis. Nevertheless, concomitant presentation is rather uncommon in imaging studies. Read More

Dtsch Arztebl Int 2022 02;119(6):87

Hand (N Y) 2022 Mar 10:15589447211049520. Epub 2022 Mar 10.

Long Island Plastic Surgical Group, PC, Garden City, NY, USA.

Primary synovial chondromatosis is a rare, benign proliferative disease of the joint synovium, tenosynovium, or bursal lining, in which cartilage metaplasia leads to the development of multiple intra-articular and periarticular loose osteocartilaginous bodies. This disease usually involves larger joints (knee, hip, elbow, and shoulder), but it has also rarely been reported in the hand. Patients with this disease complain of pain, swelling, nodules, and decreased range of motion of the affected joint. Read More

World J Clin Cases 2022 Feb;10(5):1645-1653

Orthpoeadic Medical Center, Jilin University Second Hospital, Changchun 130041, Jilin Province, China.

Background: Synovial chondromatosis is a disease originating from the synovium and characterized by the presence of metaplastic cartilaginous nodules in synovial cavities. The exact prevalence of synovial chondromatosis remains unknown, and the involvement of the shoulder joint is very rare. Synovial chondromatosis accompanied by subluxation of the humeral head without a history of trauma is rarely encountered, and to our knowledge, no published reports describe this condition. Read More

J Knee Surg 2022 May 21;35(6):597-606. Epub 2022 Feb 21.

The Center for Orthopedic Research and Eduction (CORE) Institute, Phoenix, Arizona.

Intra-articular tumors of the knee are most commonly benign. Overall, this is a relatively rare clinical presentation. The differential diagnosis includes pigmented villonodular synovitis, synovial chondromatosis, lipoma arborescens, synovial hemangioma, and very rarely primary sarcoma (synovial sarcoma being the most common). Read More

Ann Pathol 2022 Apr 15;42(3):242-248. Epub 2022 Feb 15.

Service d'anatomie pathologique et de neuropathologie, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France; Inserm MMG, Aix-Marseille Université, Marseille, France.

Translocations involving FN1 gene have been described in several tumours, which share the presence of a cartilaginous matrix with or without calcifications and a good prognosis. They encompass: soft tissue chondroma, synovial chondromatosis, calcifying aponeurotic fibroma, phosphaturic mesenchymal tumour and a new spectrum of tumours: "the calcified chondroid mesenchymal neoplasms". We review all the clinical, histopathological and molecular data of these tumours and discuss the differential diagnoses. Read More

Arthrosc Tech 2022 Feb 20;11(2):e183-e188. Epub 2022 Jan 20.

Department of Orthopaedics and Traumatology, North District Hospital, Hong Kong.

Surgical treatment has been recommended as the first choice of therapy in second and third stages of the disease. Complete synovectomy and removal of all loose bodies is advisable for prevention of recurrence of the disease. Recently, arthroscopic treatment of synovial chondromatosis is gaining popularity because of its favorable outcomes and very low complication and recurrence rates. Read More

Hand Surg Rehabil 2022 Jun 9;41(3):411-412. Epub 2022 Feb 9.

Institut Monégasque de Médecine et Chirurgie Sportive (IM2S), 11 Avenue d'Ostende, 98000 Monaco, Monaco.

World J Clin Cases 2022 Jan;10(2):685-690

Department of Pediatric Orthopedic, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China.

Background: Synovial chondromatosis (SC) is a rare benign lesion first reported by Ambrose Pare in 1558. It is most common in the knee joint, followed by the hip joint and elbow joint. It is characterized by the presence of multiple pearl-like osteochondral bodies in the joint. Read More

BMJ Case Rep 2022 Jan 21;15(1). Epub 2022 Jan 21.

Department of Orthopaedic Surgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Synovial chondromatosis is a rare, benign condition occurring due to metaplasia of synovium. A 65-year-old woman presented with pain in her right hip for 6 years. On examination, a swelling was palpable at the base of scarpa's triangle and her right hip movements were restricted. Read More

J Clin Imaging Sci 2021 4;11:66. Epub 2021 Dec 4.

Department of Radiology, Mayo Clinic Arizona, Phoenix, Arizona, United States.

There is a wide spectrum of head and neck cartilaginous lesions which include both neoplastic and nonneoplastic processes. Cartilaginous tumors of the head and neck are uncommon, posing a diagnostic challenge. Benign cartilaginous tumors that may occur in the head and neck include chondroma, chondroblastoma, chondromyxoid fibroma, osteochondroma, and synovial chondromatosis. Read More

BMC Pediatr 2022 Jan 3;22(1). Epub 2022 Jan 3.

Department of Pediatric Orthopedics, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, 410005, Hunan, China.

Backgroud: Synovial chondromatosis is a rare synovial-derived metaplasia disease that comes from the formation of cartilage nodules within the synovial connective tissue of the joint. Knee tuberculosis is a disease caused mostly by the pulmonary tuberculosis and a few by tuberculosis of the digestive tract and lymphatic. tube. Read More

Medicine (Baltimore) 2021 Nov;100(47):e27796

Department of Orthopedic Surgery, Wonkwang University Sanbon Hospital, Gunpo, Republic of Korea.

Rationale: Synovial chondromatosis of the shoulder joint is uncommon; this condition usually affects the knee joint and the hip joint. Lesions of multiple chondral nodules form in the synovium and are usually found within the joint capsule. Treatment of synovial chondromatosis consists of loose body removal and synovectomy. Read More

Stomatologiia (Mosk) 2021 ;100(6):92-96

Central Research Institute of Dental and Maxillofacial Surgery, Moscow, Russia.

The article reports a patient with an unusually large synovial chondromatosis of the temporomandibular joint. In this clinical case, the extremely rare sizes of chondral bodies are given, because of which it was required to expand the standard access to the TMJ with the isolation of the trunk and branches of the facial nerve. Read More

Case Rep Dent 2021 11;2021:5927215. Epub 2021 Dec 11.

Department of Oral and Maxillofacial Surgery, Nara Medical University, Japan.

Here, we report a case of synovial chondromatosis of the temporomandibular joint (TMJ) with numerous loose bodies. A 56-year-old woman was examined in the oral surgery department for trismus and pain in the left TMJ when opening the mouth. Imaging indicated TMJ synovial chondromatosis, and the patient was referred to our department for further examination. Read More

Br J Oral Maxillofac Surg 2022 02 30;60(2):140-144. Epub 2021 Mar 30.

Oncological Department of Oral & Maxillofacial Surgery, the First Affiliated Hospital (the Affiliated Stomatological Hospital) of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Institute of Stomatology, No. 137 Li YuShan South Road, Urumqi, Xinjiang, China. Electronic address:

The aim of this paper was to investigate the clinical and magnetic resonance imaging (MRI) features of synovial chondromatosis (SC) of the temporomandibular joint (TMJ). Fourteen patients with SC of the TMJ were included in the study. Clinical and MRI features were analysed and divided into three types based on MRI classification: type I with loose bodies, type II with homogeneous masses, and type III with a mixture of loose bodies and homogeneous masses. Read More

Reumatol Clin (Engl Ed) 2021 Dec;17(10):622-623

Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, C block, Rai Bareilley Road, 226014 Lucknow, India. Electronic address:

Biomed Mater 2021 12 9;17(1). Epub 2021 Dec 9.

School of Mechanical, Medical and Process Engineering, Centre for Biomedical Technologies, Queensland University of Technology (QUT), Brisbane, QLD 4000, Australia.

Inflammation is a critical process in disease pathogenesis and the restoration of tissue structure and function, for example, in joints such as the knee and temporomandibular. Within the innate immunity process, the body's first defense response in joints when physical and chemical barriers are breached is the synovial macrophages, the main innate immune effector cells, which are responsible for triggering the initial inflammatory reaction. Macrophage is broadly divided into three phenotypes of resting M0, pro-inflammatory M1-like (referred to below as M1), and anti-inflammatory M2-like (referred to below as M2). Read More

Arthrosc Tech 2021 Oct 14;10(10):e2265-e2270. Epub 2021 Sep 14.

Dovigi Orthopaedic Sports Medicine Clinic, Mount Sinai Hospital, Toronto, Ontario, Canada.

Synovial chondromatosis is a benign metaplastic disease of the synovial joints, characterized by the development of cartilaginous nodules in the synovium. Treatment generally includes open or arthroscopic loose body removal combined with a synovectomy. An all-arthroscopic approach has been described to minimize complications and reduce morbidity while providing adequate control of local disease. Read More

Surg Pathol Clin 2021 Dec 7;14(4):665-677. Epub 2021 Oct 7.

Department of Pathology, Azienda Ospedale-Università Padova, Padua, Italy; Department of Medicine, University of Padua School of Medicine, Padua, Italy. Electronic address:

The intra-articular space is a relatively rare site of occurrence of neoplastic diseases. The 2 distinct groups of clinicopathologic entities that exhibit an almost exclusive tropism for the joints are represented by synovial chondromatosis and tenosynovial giant cell tumors (TGCT). Synovial chondromatosis is a locally aggressive chondrogenic neoplasm that very rarely can show malignant behavior. Read More

Proc (Bayl Univ Med Cent) 2021 12;34(6):701-702. Epub 2021 Aug 12.

Department of Orthopedic Surgery, Coptic Medical Association of North America Research Institute , Dallas , Texas.

Synovial chondromatosis (SC) is a benign metaplastic proliferation of cartilaginous nodules within the synovial membrane. Primary SC, though a rare monoarticular disease, significantly impacts patients' functional and pain-related outcomes. We outline the case of a 52-year-old man who presented with a large mass on the volar-ulnar aspect of his left wrist. Read More