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Ann R Coll Surg Engl 2020 Jun 26:e1-e3. Epub 2020 Jun 26.

Bradford Teaching Hospitals NHS Foundation Trust, UK.

Synovial chondromatosis is a rare benign condition. It most commonly affects the large joints. Presentation in the temporomandibular joint is rare. Read More

J Postgrad Med 2020 Jun 19. Epub 2020 Jun 19.

Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.

Acta Biomed 2020 May 30;91(4-S):267-270. Epub 2020 May 30.

Villa Erbosa Hospital - Bologna.

Synovial chondromatosis is a rare benign disease, the aetiology of which is not clear. It can arise in the synovial membrane of joints, tendon sheaths, or bursae. Synovial chondromatosis is characterized by multiple loose bodies that can grow and cause symptoms such as pain, swelling and a limited range of motion. Read More

J Orthop Case Rep 2020 ;9(6):40-43

Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

Introduction: Synovial chondromatosis is a rare metaplastic disorder of the synovial membrane. Primary synovial chondromatosis of the shoulder joint is a rare localization and extra-articular localization around the shoulder is much less common.

Case Report: We report a rare case of a 13-year-old boy with primary synovial chondromatosis of the subscapular bursa. Read More

J Oral Maxillofac Surg 2020 May 15. Epub 2020 May 15.

Professor, Departments of Pathology, Oral and Maxillofacial Surgery, and Radiology, University of Tennessee Medical Center, Knoxville, TN.

Synovial chondromatosis (SC) is an infrequent, benign condition of unknown etiology affecting the synovium within articular joints. Often considered a metaplastic process, multiple cartilaginous nodules develop in the confines of the synovial membrane. In time, these cartilage nodules develop into fragments, sometimes detaching from the synovium and, thus, become loose in an adjacent synovial cavity. Read More

Am J Phys Med Rehabil 2020 Jun 10. Epub 2020 Jun 10.

Department of Radiology, Division of Radiology, Medical Faculty, Ataturk University, Erzurum, Turkey.

BMC Musculoskelet Disord 2020 Jun 13;21(1):377. Epub 2020 Jun 13.

Departments of Orthopedics, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.

Background: Primary synovial chondromatosis is a rare benign disease that occurs in the joint mucosa.

Case Presentation: In this case report, a 14-year-old gymnast sustained pain in both elbows for 2 months with limited elbow joint activity. The initial diagnosis of bilateral elbow synovial chondromatosis was performed by physical examination and imaging report. Read More

Histopathology 2020 Jun 7. Epub 2020 Jun 7.

Department of Pathology, IRCCS, Istituto Ortopedico Rizzoli, Bologna, Italy.

Aims: the aim is to evaluate the available diagnostic histologic criteria of synovial chondrosarcoma and to screen for the presence of IDH1/2 mutations in a series of cases of this malignant cartilaginous neoplasm.

Methods And Results: ten cases of synovial chondrosarcoma diagnosed at our Institute were reviewed. At presentation, all tumors occurred in adults (median age 62 years). Read More

BMJ Case Rep 2020 May 18;13(5). Epub 2020 May 18.

Radiology, PGIMER, Chandigarh, India.

A 25-year-old man presented to us with progressive multiple joint pain, enlargement, and restricted movements. X-rays showed platyspondyly, multiple epiphyseal widening, synovial chondromatosis, and decreased bone stock and cortical thickness. Genetic testing showed biallelic pathogenic variants in CCN6 which confirmed the diagnosis of progressive pseudorheumatoid dysplasia. Read More

BMC Musculoskelet Disord 2020 May 7;21(1):283. Epub 2020 May 7.

Department of Orthopaedics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Background: Synovial sarcoma (SS) is one of the reported sarcomas in the pediatric and adult populations. Delay in diagnosis and treatment is common in SS cases. SS may be excised before the correct diagnosis is made. Read More

J Maxillofac Oral Surg 2020 Jun 9;19(2):230-234. Epub 2019 Feb 9.

Vydehi Institute of Dental Sciences, Bangalore, India.

Synovial chondromatosis is a rare condition characterized by the presence of loose cartilaginous bodies, due to the abnormal proliferation of synovial membrane. However, its manifestation in the temporomandibular joint is a rare finding, occurring predominantly in females. This case report describes the clinical features, diagnosis and management of a case of synovial chondromatosis. Read More

Oral Radiol 2020 Apr 18. Epub 2020 Apr 18.

Department of Oral and Maxillofacial Radiology, Aichi Gakuin University School of Dentistry, 2-11 Suemori-dori Chikusa-ku, Nagoya, 464-8651, Japan.

Objectives: The present study aimed to clarify the characteristic computed tomography (CT) features that indicate synovial chondromatosis (SC) with a few small calcified bodies or without calcification on panoramic images, and to discuss their differences from the features of temporomandibular disorder (TMD).

Methods: Panoramic and CT images from 11 patients with histologically verified SC of the temporomandibular joint were investigated. Based on the panoramic images, the patients were classified into a distinct group (5 patients) with typical features of calcified loose bodies and an indistinct group (6 patients) without such bodies. Read More

Clin Case Rep 2020 Apr 5;8(4):640-643. Epub 2020 Feb 5.

Department of Oral Surgery and Oral Medicine Faculty of Dentistry University of Oslo Oslo Norway.

Calcium pyrophosphate dehydrate deposition (CPDD) disease very rarely affects the temporomandibular joint (TMJ). It may resemble synovial chondromatosis, chondrosarcoma, chondroblastoma, or a parotid tumor. Clinical examination, CT, and MRI are important in making the correct diagnosis. Read More

J Postgrad Med 2020 Apr-Jun;66(2):112-113

Department of Pathology, Seth G.S. Medical college and KEM Hospital, Mumbai, Maharashtra, India.

Magn Reson Imaging Clin N Am 2020 May;28(2):301-316

Department of Radiology, University of California San Diego, School of Medicine, UCSD Teleradiology and Education Center, 408 Dickinson Street, Mail Code #8226, San Diego, CA 92103-8226, USA.

This article discusses the most common tumor and tumor-like lesions arising at the shoulder. Osseous tumors of the shoulder rank second in incidence to those at the knee joint and include benign osteochondromas and myeloma or primary malignant lesions, such as osteosarcoma or chondrosarcomas. Soft tissue tumors are overwhelmingly benign, with lipomas predominating, although malignant lesions, such as liposarcomas, can occur. Read More

Open Access Maced J Med Sci 2019 Dec 20;7(24):4347-4350. Epub 2019 Dec 20.

Department of Human and Animal Physiology, Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam.

Background: "False patellar duplication" is a situation where there are two pieces in the position of a knee-joint like patella. It can derive from cartilage tumors, soft tissue tumors, or gout tumors, or due to the heterotopic ossification, forming a sub patella in the knee joint.

Case Report: A woman, 57 years old, healthy history, she has hospitalized for right knee joint pain since 2 years. Read More

Cartilage 2020 Mar 20:1947603520912316. Epub 2020 Mar 20.

Institute of Sports Medicine, Peking University Third Hospital, Beijing, China.

Purpose: Evaluate the clinical outcomes after arthroscopic treatment of synovial chondromatosis (SC) of the hip.

Materials And Methods: We evaluated patients who underwent arthroscopic management for SC of the hip from November 2008 to March 2017. Radiographic evaluation was made before and after surgery. Read More

Mol Clin Oncol 2020 Apr 18;12(4):355-357. Epub 2020 Feb 18.

Department of Orthopedic Surgery, Kindai University Hospital, Osaka-Sayama, Osaka 589-8511, Japan.

Synovial osteochondroma (SO) is a relatively uncommon tumor affecting the synovial joints that is characterized by the development of hyaline cartilage from the synovial membrane. The basic pathophysiology of SO is thought to be the metaplastic change of the synovium to hyaline cartilage. Large extra- or para-articular lesions in the Hoffa's fat pad are relatively uncommon. Read More

Radiol Case Rep 2020 May 21;15(5):445-449. Epub 2020 Feb 21.

Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Extra-articular synovial chondromatosis is a rare entity in the foot and ankle. We present a case of a 49-year-old female who presented for evaluation of a palpable concern following trauma; which was found to represent synovial chondromatosis. This case demonstrates the multimodality imaging findings, including ultrasound and MRI, with histopathologic correlation. Read More

Clin Orthop Surg 2020 Mar 13;12(1):68-75. Epub 2020 Feb 13.

Department of Orthopedic Surgery, Eiju General Hospital, Tokyo, Japan.

Background: Synovial chondromatosis occurs rarely in the shoulder, and its details remain unclear. The purpose of this study was to clarify the clinical results of surgical resection and the histopathological findings of synovial chondromatosis in the shoulder.

Methods: Ten shoulders with synovial chondromatosis that had been operatively resected were reviewed retrospectively. Read More

J Clin Orthop Trauma 2020 Mar-Apr;11(2):317-320. Epub 2019 Dec 14.

Department of Radiology, Turku University Hospital, Turku, Finland.

A child with shoulder pain and great palpable mass without any injury history is an emergent case until the diagnosis is confirmed. We report the clinical findings, imaging features, surgery and histological analyses of primary synovial chondromatosis in glenohumeral joint, biceps tendon sheath and subcoracoid bursa in a child, aged 14. Primary synovial chondromatosis is characterised by multiple calcified nodules in joints, tendons or bursa areas. Read More

Int J Surg Pathol 2020 Feb 23:1066896920908054. Epub 2020 Feb 23.

Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.

. Nodular fasciitis (NF) is a self-limiting, benign mesenchymal neoplasm of fibroblastic/myofibroblastic origin. Due to the fast growth, cellularity, and frequently observed high mitotic count, it is commonly misdiagnosed as a sarcoma, often resulting in overtreatment. Read More

Arch Argent Pediatr 2020 02;118(1):e34-e40

Servicio de Cirugía Ortopédica y Traumatología. Hospital Clínico Universitario-Malvarrosa, Valencia, España.

Synovial osteochondromatosis consists of a synovial metaplasia which affects 1 per 100 000 people. It is a very rare disease among children. It typically affects large joints of the body, especially the knee. Read More

Head Neck Pathol 2020 Mar 16;14(1):83-96. Epub 2020 Jan 16.

Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, The Ottawa Hospital/University of Ottawa, 501 Smyth Rd, 4th Floor CCW, Room 4250, Ottawa, ON, K1H 8L6, Canada.

Clinically, radiologically, and pathologically, chondroid neoplasms of the skull can be diagnostically challenging due to overlapping features in each of these domains. Compounding the problem for the pathologist, there is also significant morphologic, immunophenotypic, and molecular genetic overlap between benign and malignant cartilaginous lesions, and the majority of these lesions are encountered quite rarely in routine surgical pathology practice. Each of these factors contribute to the diagnostic difficulty posed by these lesions, highlighting the importance of radiologic-pathologic correlation in the diagnosis. Read More

Skeletal Radiol 2020 Jun 7;49(6):921-928. Epub 2020 Jan 7.

Department of Radiology, Thomas Jefferson University Hospital, 132 S. 10th Street, 10th Floor, Philadelphia, PA, 19107, USA.

Objective: A variety of benign and neoplastic lesions can affect the synovium, including pigmented villonodular synovitis (PVNS) and synovial chondromatosis. Prior to surgical resection, accurate characterization of synovial lesions is necessary for appropriate treatment planning. Additionally, recent advances in potential medical therapies for PVNS could decrease or eliminate the need for surgery in some cases. Read More

Arthrosc Tech 2019 Dec 9;8(12):e1495-e1499. Epub 2019 Nov 9.

Department of Orthopaedic Surgery, Tohoku Orthopaedic Clinic, Kamiyagari, Izumi-ku, Sendai-city, Japan.

We orthopaedic surgeons are not familiar with the popliteus bursa. It is defined as the expansion in the synovial membrane of the posterolateral part of the knee that lies between the lateral meniscus and the tendon of the popliteus muscle. The popliteus bursa extends approximately 1 cm distal to the joint line and has 4 borders; the medial border is the peripheral margin of the lateral meniscus, the lateral border is the popliteus tendon, and the superior and inferior borders are formed by 2 fascicles. Read More

Radiol Case Rep 2020 Mar 20;15(3):218-221. Epub 2019 Dec 20.

Tripler Army Medical Center, 1 Jarrett White Road Tripler AMC, Hawaii 96859.

Juvenile idiopathic arthritis (JIA) is the most common cause of arthritis in children. It is characterized by inflammatory cell infiltration of synovial membranes leading to synovitis and synovial membrane thickening. Synovial chondromatosis is rare sequela of synovitis in which foci of cartilage develop within the synovial membrane of a joint capsule. Read More

World J Orthop 2019 Nov 18;10(11):404-415. Epub 2019 Nov 18.

Orthopedic and Trauma Unit, ASST Settle Laghi, Varese 21100, Italy.

Background: Primary synovial chondromatosis (PSC) is a rare arthropathy of the synovial joints characterized by the formation of cartilaginous nodules, which may detach and become loose bodies within the joint and may undergo secondary proliferation. PSC of the foot and ankle is exceedingly rare, with only a few cases reported in the literature. The diagnosis may be difficult and delayed until operative treatment, when it is confirmed by histological assessment. Read More

Med Mol Morphol 2020 Jun 9;53(2):82-85. Epub 2019 Dec 9.

Oral Anatomy, Osaka Dental University, 1-5-17, Otemae, Chuo-ku, Osaka, 540-0008, Japan.

The aim of this study is to reveal the morphological property about the loose bodies (LBs) of temporomandibular joint (TMJ) by scanning electron microscope (SEM). We obtained specimens from two female cases of released loose body by surgical operation. These specimens were fixed by soaking in a mixture of 5% glutaraldehyde or 4% formaldehyde for one week. Read More

J Ultrason 2019 Nov 30;19(78):212-221. Epub 2019 Sep 30.

University Surgical Clinic "St. Naum Ohridski" Skopje, University "Ss. Cyril and Methodius", Skopje, Macedonia.

High-resolution ultrasonography has many advantages in the imaging of the musculoskeletal system, when compared to other imaging methods, particularly in superficial, easily accessible parts of the body. It is a perfect diagnostic tool for visualizing the most common pathologies of the musculoskeletal system, including the bursae. Inflammation of bursae is frequent, and it can mimic other diseases of the musculoskeletal system. Read More

Medicine (Baltimore) 2019 Dec;98(49):e18269

Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.

Rationale: Giant synovial osteochondromatosis of the thigh is a highly unusual disease without standard diagnosis and curative managements so far. Our focus is to report a very rare case of giant synovial osteochondromatosis successfully operated by surgical treatment. The management of these unique cases has certain educational significance in clinical practice. Read More

Skeletal Radiol 2020 Apr 23;49(4):645-650. Epub 2019 Nov 23.

Department of Radiology, University of California San Diego, San Diego, CA, USA.

Synovial chondromatosis is a rare disease that causes disability and dysfunction of the involved synovial joint. We describe the second case in the literature of intraligamentous synovial chondromatosis involving the anterior cruciate ligament, confirmed by pathology after arthroscopic removal of the chondral bodies. We also describe associated magnetic resonance imaging findings which may be helpful for diagnosis of this very rare entity. Read More

Cureus 2019 Oct 4;11(10):e5839. Epub 2019 Oct 4.

Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA.

Chondrosarcoma is the second most common primary malignant bone tumor. While the majority arrive de novo, a minority arise from malignant transformation of benign neoplasms, such as osteochondromas. Rarely, chondrosarcomas have been found to originate from other preexisting lesions, such as synovial chondromatosis. Read More

AME Case Rep 2019 11;3:38. Epub 2019 Oct 11.

School of Medicine, University of New South Wales, Sydney, Australia.

Lumbar radiculopathy is usually caused by nerve compression due to herniated disc material or compression by degenerative pathology such as enlarged facet joints, thickened ligamentum flavum or synovial cysts. We report the case of a 48-year-old female with L5 sciatica due to an osteochondral loose body in the foramen. This is only the third reported case of a single osteochondral loose body in the lumbar spine and the first reported case found in the foramen. Read More

Virchows Arch 2020 Jan 7;476(1):121-134. Epub 2019 Nov 7.

Bone and Soft Tissue Study Group, Taiwan Society of Pathology, Kaohsiung, Taiwan.

Soft tissue tumors encompass a wide variety of mesenchymal neoplasms exhibiting diverse clinical, pathologic, and molecular features. Among these, osteoid and/or chondroid matrix deposition in some soft tissue tumors represents a noticeable characteristic. Unlike matrices present in bone tumors where they likely reveal the respective cells of origin (i. Read More

J Craniomaxillofac Surg 2019 Dec 23;47(12):1898-1902. Epub 2019 Oct 23.

Maxillo-Facial Surgery Department, 'Sapienza' Università di Roma, Via del Policlinico, Roma, Italy.

Synovial chondromatosis (SC) of the temporomandibular joint is a pseudoneoplastic condition characterized by benign cartilaginous metaplasia of synovial tissue mesenchymal residues with intra-articular nodule formation. TMJ involvement is rare. Interposition of loose bodies in the articular space can generate pressure, leading to glenoid fossa erosion with intracranial extension. Read More

Bone 2020 Jan 23;130:115116. Epub 2019 Oct 23.

Departments of Orthopaedic Surgery, The University of Pennsylvania, 3450 Hamilton Walk, 309A Stemmler Hall, Philadelphia, PA 19104, United States; Departments of Medicine, The University of Pennsylvania, 3450 Hamilton Walk, 309A Stemmler Hall, Philadelphia, PA 19104, United States; Departments of The Center for Research in FOP & Related Disorders, The Perelman School of Medicine at The University of Pennsylvania, 3450 Hamilton Walk, 309A Stemmler Hall, Philadelphia, PA 19104, United States. Electronic address:

Rationale: Fibrodysplasia ossificans progressiva (FOP) is primarily a disease of progressive heterotopic ossification (HO) leading to impaired mobility throughout life. An additional diagnostic feature is a characteristic malformation of the great toes. The culpable gene for FOP,ACVR1 (activin A receptor type 1) has a clear effect on the induction of extra-skeletal bone formation. Read More

J Clin Rheumatol 2019 Oct 23. Epub 2019 Oct 23.

Departments of Diagnostic Imaging.

Int J Rheum Dis 2019 Nov 24;22(11):2073-2079. Epub 2019 Oct 24.

Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, China.

We describe a previously unreported association of ankylosing spondylitis with synovial chondromatosis, and briefly review previously reported cases and treatment of synovial chondromatosis in patients with other immune-mediated inflammatory arthritides. A 20-year-old man with ankylosing spondylitis whose axial disease was in remission with nonsteroidal anti-inflammatory drugs and oral disease-modifying anti-rheumatic drugs developed recurrent right knee pain and swelling. Magnetic resonance imaging of his right knee revealed calcified loose bodies, suggestive of synovial chondromatosis. Read More

J Maxillofac Oral Surg 2019 Dec 23;18(4):543-546. Epub 2019 Jan 23.

2Department of Oral and Maxillofacial surgery, Sree Anjaneya Institute of Dental Sciences, Modakkalloor, Calicut, Kerala India.

Genes Chromosomes Cancer 2020 03 18;59(3):144-151. Epub 2019 Oct 18.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Synovial chondromatosis (SC) is a rare benign cartilaginous neoplasm in which recurrent fibronectin 1 (FN1) and activin receptor 2A (ACVR2A) gene rearrangements have been recently reported. Triggered by a case of malignant transformation in SC (synovial chondrosarcoma) showing a novel KMT2A-BCOR gene fusion by targeted RNA sequencing, we sought to evaluate the molecular abnormalities in a cohort of 27 SC cases using a combined methodology of fluorescence in situ hybridization (FISH) and/or targeted RNA sequencing. Results showed that FN1 and /or ACVR2A gene rearrangements were noted in 18 cases (67%), with an FN1-ACVR2A fusion being confirmed in 15 (56%) cases. Read More

Br J Hosp Med (Lond) 2019 Oct;80(10):618

Consultant in Trauma and Orthopaedics, Department of Trauma and Orthopaedic Surgery, Warrington Hospital, Warrington.

N Engl J Med 2019 Oct;381(14):1364

Kalinga Institute of Medical Sciences, Bhubaneswar, India

Med Oral Patol Oral Cir Bucal 2019 Sep 1;24(5):e562-e570. Epub 2019 Sep 1.

Av. Prof. Lineu Prestes, 2227, Cidade Universitária 05508-900, São Paulo - SP, Brazil,

Background: To investigate the incidence of temporomandibular arthropathies diagnosed in a university center and to describe their histopathological characteristics.

Material And Methods: Temporomandibular arthropathy cases with corresponding slides were selected from an oral and maxillofacial surgical pathology service. Cases of exclusively articular disc disease were not included. Read More

J Clin Rheumatol 2019 Aug 13. Epub 2019 Aug 13.

From the Rheumatology Department, Centro Hospitalar Vila Nova de Gaia/Espinho EPE, Vila Nova de Gaia, Portugal.

Pan Afr Med J 2019;33:41. Epub 2019 May 21.

Rheumatology Department, Kassab Institute of Orthopedic Surgery, Ksar Said, Tunisia.

Rev Bras Ortop (Sao Paulo) 2019 Feb 1;54(1):78-82. Epub 2019 Mar 1.

Faculdade de Medicina, Departamento de Ortopedia, Universidade de São Paulo, São Paulo, SP, Brasil.

Synovial chondromatosis is a rare condition characterized by benign chondrogenic meta- plasia of extra-articular synovial tissue. It usually affects a single tendon sheath of the hand or foot. This report describes a rare case with extensive synovial chondromatosis affecting all flexor tendons in the tarsal tunnel, its radiological features, surgical treatment, and clinical outcome. Read More

Shoulder Elbow 2019 Aug 24;11(4):275-281. Epub 2018 Jan 24.

Division of Orthopaedics, Addenbrooke's Hospital, Cambridge University Hospitals Trust, Cambridge, UK.

Osteochondritis dissecans (OCD) of the humeral head is rare and usually occurs in adolescents. Secondary synovial chondromatosis occasionally occurs in the shoulder but has only been reported twice in an adolescent. We describe the case and management of an adolescent male who presented with features of OCD and secondary chondromatosis in his shoulder occurring simultaneously. Read More

Reumatismo 2019 Jul 9;71(2):81-84. Epub 2019 Jul 9.

Department of Radiology, University of Verona.

Synovial chondromatosis (SC) is a rare condition with a very variable clinical presentation, thus making the diagnosis not immediate. We report a case of massive primary SC of the knee, properly evaluated with X-rays, ultrasonography and magnetic resonance imaging and successfully treated with an arthroscopic approach. Read More

Skeletal Radiol 2019 Dec 10;48(12):1875-1890. Epub 2019 Jul 10.

Department of Radiology, Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30.001, 9700, RB, Groningen, The Netherlands.

The purpose of this article is to review calcified or ossified benign soft tissue lesions that may simulate malignancy. We review the clinical presentations, locations, imaging characteristics, and differential diagnostic considerations of myositis ossificans, tophaceous gout, benign vascular lesions, calcific tendinopathy with osseous involvement, periosteal chondroma, primary synovial chondromatosis, Hoffa's disease, tumoral calcinosis, lipoma with metaplasia, calcifying aponeurotic fibroma, calcific myonecrosis, ancient schwannoma, and Castleman disease. Read More