46,339 results match your criteria Synovial Cell Sarcoma


Intra-articular injection of hydrogen sulfide decreased the progression of gonarthrosis.

Can J Physiol Pharmacol 2018 Dec 6:1-8. Epub 2018 Dec 6.

d Department of Pharmacology, University of Giresun, Giresun, Turkey.

Hydrogen sulfide (HS) is found in both the plasma and synovial fluid of patients with gonarthrosis. In the present study, we investigated whether intra-articular injection of sodium hydrosulfide (NaSH) (1 mM, 30 μL), a HS donor, might affect gonarthrosis in rats. Gonarthrosis was induced surgically in the left knees of rats and left for 6 weeks for the development of disease. Read More

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December 2018
4 Reads

Diagnosis and Management of Fungal Periprosthetic Joint Infections.

J Am Acad Orthop Surg 2018 Dec 4. Epub 2018 Dec 4.

From the Sinai Hospital of Baltimore, Baltimore, MD (Dr. Nace), the Philadelphia College of Osteopathic Medicine, Philadelphia, PA (Dr. Siddiqi), the New England Baptist Hospital, Boston, MA (Dr. Talmo), and the Brigham and Women's Hospital, Boston, MA (Dr. Chen).

Fungal periprosthetic joint infection (PJI) is a devastating complication because it can be difficult to diagnose, manage, and eradicate. Fungal PJI treatment requires a systematic approach. Increased awareness is essential when patients with painful arthroplasties present with immunosuppression, significant comorbidities, multiple surgeries, and history of drug use. Read More

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December 2018
2 Reads

Bacterial detection and identification from human synovial fluids on an integrated microfluidic system.

Analyst 2018 Dec 6. Epub 2018 Dec 6.

Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan. and Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan and Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan.

Periprosthetic joint infections (PJIs) are among the most severe complications emerging from prosthetic joint replacement surgeries. In order to possess a rapid means of diagnosing PJIs, an integrated microfluidic system was developed herein for detecting and identifying bacteria in human synovial fluid (HSF). The entire molecular diagnostic process, including (1) sample treatment, (2) bacterial isolation, (3) bacterial lysis, (4) nucleic acid amplification (via polymerase chain reaction (PCR)), and (5) optical detection, could be automated on a single chip. Read More

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December 2018

Penetration and efficacy of transdermal NSAIDs in a model of acute joint inflammation.

J Pain Res 2018 13;11:2809-2819. Epub 2018 Nov 13.

InterVivo Solutions Inc, Toronto, ON, Canada.

Purpose: Prescription and OTC non-steroidal anti-inflammatory drugs (NSAIDs) are ubiquitous treatments for pain and inflammation; however, oral administration of these drugs may produce gastrointestinal (GI) side effects. Transdermal (TD) administration of NSAIDs circumvents these adverse events by avoiding the GI tract and, presumably, achieves regional drug levels of therapeutic effect and thereby, fewer off-target complications.

Methods: A drug quantification method was developed for ibuprofen and celecoxib in canine plasma and synovial fluid using liquid chromatography and mass spectrometry. Read More

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November 2018

Ultrasound thresholds for synovial abnormalities.

Authors:
Joanna Collison

Nat Rev Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

Nature Reviews Rheumatology, .

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December 2018

Enriched Cd141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Molecular Rheumatology, School of Medicine, Trinity College Dublin, Ireland.

CD141+ DC are implicated in antiviral and antitumor immunity. However, mechanistic studies in autoimmune disease are limited. This is the first study to our knowledge examining CD141+ DC in autoimmune disease, specifically inflammatory arthritis (IA). Read More

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December 2018

Synovial cysts of the hip joint: a single-center experience.

BMC Surg 2018 Dec 5;18(1):113. Epub 2018 Dec 5.

Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Background: Synovial cyst of the hip joint is a rare clinical condition in need of evidence-based guidelines for its diagnosis and management. Normally, synovial cyst of the hip joint requires no treatment, but when it intrudes into surrounding structures, various clinical symptoms appear. Because of its rarity, a symptomatic synovial cyst is often confounded with a tumor as a space-occupying lesion or with other diseases, depending on its various clinical presentations. Read More

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December 2018
1 Read

Cannabinoid receptor 2 agonist prevents local and systemic inflammatory bone destruction in rheumatoid arthritis.

J Bone Miner Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Orthopedics, The First Affiliated Hospital of Soochow University.

Cannabinoid receptor 2 (CB2) has been implicated as an important clinical regulator of inflammation and malignant osteolysis. Here, we observed that CB2 expression was markedly higher in the collagen-induced arthritis (CIA) mice synovium and bone tissues than in the non-inflamed synovium and bone tissues. The CB2 selective agonist (JWH133) but not antagonist (SR144528) suppressed CIA in mice without toxic effects, as demonstrated by the decreased synovial hyperplasia, inflammatory responses, cartilage damage, and periarticular and systemic bone destruction. Read More

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December 2018

The level of synovial AXL expression determines the outcome of inflammatory arthritis, possibly depending on the upstream role of TGF-β1.

Rheumatology (Oxford) 2018 Dec 1. Epub 2018 Dec 1.

Experimental Rheumatology, Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

Objective: To investigate the role of AXL, a member of the anti-inflammatory TYRO3, AXL MER (TAM) receptor family, in arthritis.

Methods: KRN serum transfer arthritis was induced in Axl-/- and wild-type mice. Knee and ankle joints were scored macro- and microscopically. Read More

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December 2018

Synovial sarcoma: when epigenetic changes dictate tumour development.

Swiss Med Wkly 2018 11 2;148:w14667. Epub 2018 Dec 2.

Experimental Pathology Service, Institute of Pathology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland.

Synovial sarcoma is a highly aggressive soft tissue malignancy that often affects adolescents and young adults. It is associated with a unique chromosomal translocation that results in the formation and expression of the fusion gene SS18-SSX, which underlies its pathogenesis. Although SS18-SSX provides a potentially unique therapeutic target, all attempts to neutralise it have been unsuccessful thus far. Read More

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November 2018

Canonical Wnt/β-catenin signaling activation in soft-tissue sarcomas: A comparative study of synovial sarcoma and leiomyosarcoma.

Rare Tumors 2018 25;10:2036361318813431. Epub 2018 Nov 25.

Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

Background: Previous studies have shown that aberrant activation of the Wnt/β-catenin pathway is associated with many malignant neoplasms. This includes some soft-tissue sarcoma phenotypes, most notably synovial sarcoma, implicating potential targets for novel molecular therapies.

Objective: We investigate the level of Wnt/β-catenin pathway activation present in leiomyosarcomas relative to synovial sarcomas, using expression of LEF1 and β-catenin as surrogates. Read More

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November 2018

Factors Affecting the Extent of Graft Tendon Synovialization after Double-Bundle Anterior Cruciate Ligament Reconstruction: Based on Second-Look Arthroscopic Findings.

Clin Orthop Surg 2018 Dec 21;10(4):413-419. Epub 2018 Nov 21.

Department of Orthopaedic Surgery, Pohang St. Mary's Hospital, Pohang, Korea.

Background: We aimed to examine the factors that influence synovialization of the grafted tendon after double-bundle anterior cruciate ligament (ACL) reconstruction based on second-look arthroscopic findings.

Methods: Out of 205 knees that were treated between August 2008 and May 2016 with double-bundle ACL reconstruction using bio-absorbable cross-pins and Endobuttons for femoral tunnel fixation, we enrolled 65 knees (64 patients) that underwent second-look arthroscopy with hardware removal at 1 year postoperatively. Measured clinical outcomes included the Lysholm score and Tegner activity score that were evaluated preoperatively and during the final follow-up. Read More

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December 2018

Remaining Loose Bodies after Arthroscopic Surgery Including Extensive Capsulectomy for Synovial Chondromatosis of the Hip.

Clin Orthop Surg 2018 Dec 21;10(4):393-397. Epub 2018 Nov 21.

Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: The purpose of our study was to evaluate the usefulness of hip arthroscopy including extensive capsulectomy for synovial chondromatosis of the hip.

Methods: From 2008 to 2016, 13 patients with synovial chondromatosis of the hip were treated with arthroscopic removal of loose bodies and synovectomy using three arthroscopic portals. An extensive capsulectomy was performed to allow the remaining loose bodies to be out of the extracapsular space, and the excised capsule was not repaired. Read More

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December 2018

α-Microglobulin Protects Against Bleeding-Induced Oxidative Damage in Knee Arthropathies.

Front Physiol 2018 16;9:1596. Epub 2018 Nov 16.

Department of Clinical Sciences Lund, Orthopaedics, Faculty of Medicine, Lund University, Lund, Sweden.

Knee injury increases the risk of developing knee osteoarthritis (OA). Recent evidence suggests involvement of oxidative stress induced by inflammation and bleeding in the joint. This study investigates the role in this process of α-microglobulin (A1M), a plasma and tissue antioxidant protein with reducing function, and heme- and radical-binding properties. Read More

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November 2018
1 Read

Vascular endothelial growth factor signaling in VE-cadherin expression and tube-like formation by rheumatoid arthritic synovial fibroblast-like cells.

Biochem Biophys Res Commun 2018 Nov 28. Epub 2018 Nov 28.

Department of Biochemistry, The Nippon Dental University School of Life Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo, 102-8159, Japan. Electronic address:

An increase in the vasculature is one of most representative changes in the synovial tissue of joints in rheumatoid arthritis (RA) and is closely associated with disease progression. Although the vasculatures are believed to be a result of VE-cadherin-dependent angiogenesis and a possible therapeutic target of the disease, synovial fibroblastic cells express VE-cadherin and form tube-like structures, suggesting that vasculatures in RA synovium may not simply result from angiogenesis. This paper analyzes a mechanism of VE-cadherin expression by rheumatoid arthritic synovial fibroblast-like cells (RSFLs) and their involvement in the tube-like formation. Read More

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November 2018

Dyrk1A promotes the proliferation, migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis via down-regulating Spry2 and activating the ERK MAPK pathway.

Tissue Cell 2018 Dec 28;55:63-70. Epub 2018 Oct 28.

Department of Orthopedic, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, 226001, China. Electronic address:

Fibroblast-like synoviocytes (FLSs) play an essential role in rheumatoid arthritis (RA) by promoting synovitis, pannus growth and cartilage/bone destruction. Increased proliferation, migration and invasion of FLSs greatly contribute to RA initiation and progression. Dual-specificity tyrosine-regulated kinase 1A (Dyrk1A), a serine/threonine kinase, regulates MAPK pathway activation, and governs the proliferation and differentiation of neuronal progenitor cells and cancer cells. Read More

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December 2018

Histologic evidence that mast cells contribute to local tissue inflammation in peripheral spondyloarthritis by regulating interleukin-17A content.

Rheumatology (Oxford) 2018 Dec 4. Epub 2018 Dec 4.

Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and Immunology Center.

Objectives: Synovial mast cells contain IL-17A, a key driver of tissue inflammation in SpA. A recent in vitro study showed that tissue-derived mast cells can capture and release exogenous IL-17A. The present study aimed to investigate if this mechanism could contribute to tissue inflammation in SpA. Read More

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December 2018
1 Read

Routine Diagnostic Tests for Periprosthetic Joint Infection Demonstrate a High False-Negative Rate and Are Influenced by the Infecting Organism.

J Bone Joint Surg Am 2018 Dec;100(23):2057-2065

The Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.

Background: Current guidelines recommend serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as the first-line testing for evaluation of suspected periprosthetic joint infection, in addition to synovial white blood-cell (WBC) count and polymorphonuclear percentage. However, the sensitivity and other diagnostic measures of these tests using a standardized definition of periprosthetic joint infection and the influence of organisms on these inflammatory markers remain inadequately investigated.

Methods: A retrospective review of an institutional database of 549 periprosthetic joint infection cases and 653 aseptic total joint arthroplasty revisions was performed. Read More

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December 2018
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The Urokinase Plasminogen Activation System in Rheumatoid Arthritis: Pathophysiological Roles and Prospective Therapeutic Targets.

Curr Drug Targets 2018 Dec 4. Epub 2018 Dec 4.

School of Chemistry and Molecular Bioscience, University of Wollongong, NSW 2522. Australia.

Rheumatoid arthritis (RA) is a chronic and progressive inflammatory disease characterized in its early stages by synovial hyperplasia and inflammatory cell infiltration and later by irreversible joint tissue destruction. The plasminogen activation system (PAS) is associated with a wide range of physiological and pathophysiological states involving fibrinolysis, inflammation and tissue remodeling. Various components of the PAS are implicated in the pathophysiology of RA. Read More

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December 2018

SPACIA1/SAAL1 Deletion Results in a Moderate Delay in Collagen-Induced Arthritis Activity, along with mRNA Decay of Gene.

Int J Mol Sci 2018 Nov 30;19(12). Epub 2018 Nov 30.

Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa 216-8512, Japan.

This study was performed to elucidate the molecular function of the synoviocyte proliferation-associated in collagen-induced arthritis (CIA) 1/serum amyloid A-like 1 (SPACIA1/SAAL1) in mice CIA, an animal model of rheumatoid arthritis (RA), and human RA-synovial fibroblasts (RASFs). -deficient mice were generated and used to create mouse models of CIA in mild or severe disease conditions. Cell cycle-related genes, whose expression levels were affected by small interfering RNA (siRNA), were screened. Read More

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November 2018

Thumb base osteoarthritis: A hand osteoarthritis subset requiring a distinct approach.

Best Pract Res Clin Rheumatol 2017 Oct 26;31(5):649-660. Epub 2018 Sep 26.

Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden, The Netherlands. Electronic address:

Hand osteoarthritis (OA) is usually a polyarticular disease, preferentially affecting the thumb base (TB) and interphalangeal joints. TB OA alone is generally not addressed separately, but as a part of hand OA. Studies have shown that OA in the TB joints clusters together, as does OA in the interphalangeal joints, supporting it as a distinct subset. Read More

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October 2017
1 Read

The prophylactic effect of a Eugenia aquea extract against oxidative stress and inflammation associated with the development of arthritis in an adjuvant-induced arthritis rat model.

Food Funct 2018 Dec 4. Epub 2018 Dec 4.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Germany.

Rheumatoid arthritis (RA) is the most common human autoimmune disease. A petroleum ether extract of Eugenia aquea (E. aquea) was analyzed by GC/MS. Read More

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December 2018
2 Reads

Resveratrol Alleviates Rheumatoid Arthritis via Reducing ROS and Inflammation, Inhibiting MAPK Signaling Pathways, and Suppressing Angiogenesis.

J Agric Food Chem 2018 Dec 4. Epub 2018 Dec 4.

Hubei Key Laboratory of EFGIR , Huanggang Normal University , Huanggang , Hubei 438000 , China.

Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting joints and is featured by chronic synovial inflammation and angiogenesis. We employed a bovine type-II collagen (BIIC)-induced Sprague-Dawley rat arthritis model and an in vitro RA model based on interleukin (IL)-1β-stimulated rat synovial cells (RSC-364) to explore the preventive effect of resveratrol on RA and the underlying mechanisms. We found that resveratrol ameliorated BIIC-elicited synovitis and RA-related pathological hallmarks such as inflammatory cell infiltration and angiogenesis in the synovial tissue. Read More

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December 2018
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2.912 Impact Factor

Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups.

Arthritis Res Ther 2018 Dec 3;20(1):265. Epub 2018 Dec 3.

The Centre for Arthritis and Rheumatic Diseases, Saint Vincent's University Hospital and Dublin Academic Medical Centre, University College Dublin, Elm Park, Dublin, Ireland.

Background: The aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG) and OMERACT Synovial Tissue Biopsy Group.

Methods: Participants were consulted through a modified Delphi method. Three sequential rounds occurred over 12 months. Read More

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December 2018
2 Reads

Correction to: Diffusion-weighted imaging for assessment of synovial inflammation in juvenile idiopathic arthritis: a promising imaging biomarker as an alternative to gadolinium-based contrast agents.

Eur Radiol 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiology, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

The original version of this article, published on 12 June 2017, unfortunately contained a mistake. Read More

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November 2018

MRI of THA Correlates With Implant Wear and Tissue Reactions: A Cross-sectional Study.

Clin Orthop Relat Res 2018 Nov 26. Epub 2018 Nov 26.

M. F. Koff, P. Shah, M. Miranda, H. G. Potter, MRI Research Laboratory, Hospital for Special Surgery, New York, NY, USA C. Esposito, E. Baral, T. Wright, Department of Biomechanics, Hospital for Special Surgery, New York, NY, USA K. Fields, Healthcare Research Institute, Hospital for Special Surgery, New York, NY, USA T. Bauer, Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY, USA D. E. Padgett, Adult Reconstruction and Joint Replacement Division, Hospital for Special Surgery, New York, NY, USA.

Background: MRI is predictive of adverse local tissue reactions (ALTRs) after THA but how MRI directly relates to implant surface wear, fretting, and trunnion corrosion at different articulations between implant components remains unclear. MRI generates high-contrast images to display soft tissues around arthroplasty and may provide a surgeon the means to distinguish and differentiate host-related synovial patterns as a response to either polyethylene wear or metal wear and corrosion products.

Questions/purposes: The purposes of this study were (1) to correlate findings from MRI in patients who have undergone THA with direct assessment of implant wear, corrosion, and fretting from retrieved components; and (2) to distinguish the unique synovial responses on MRI in patients who have undergone THA based on bearing materials. Read More

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November 2018
3 Reads

Methyl jasmonate a stress phytohormone attenuates LPS induced in vivo and in vitro arthritis.

Mol Biol Rep 2018 Nov 29. Epub 2018 Nov 29.

Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Velan Nagar, P. V. Vaithiyalingam Road, Pallavaram, Chennai, Tamil Nadu, 600 117, India.

The objective of present study was to screen the effect of methyl jasmonate (MJ) in lipopolysaccharide (LPS) induced in vivo and in vitro arthritis. Arthritis was induced in wistar rats by intraplantar administration of LPS (1 mg/Kg) and effect of MJ was screened in two doses (20, 40 mg/Kg, IP), indomethacin (30 mg/Kg p.o) was used as standard. Read More

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November 2018
2 Reads

Increased Autophagy Enhances the Resistance to Tumor Necrosis Factor-Alpha Treatment in Rheumatoid Arthritis Human Fibroblast-Like Synovial Cell.

Biomed Res Int 2018 25;2018:4941027. Epub 2018 Oct 25.

Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Tumor Necrosis Factor-alpha (TNF-) was reported to increase autophagy in rheumatoid arthritis human fibroblast-like synovial cell (RA-HFLS). We investigated different levels of TNF- exposed to RA-HFLS by focusing on the relationship of autophagy and apoptosis. RA-HFLS and normal human fibroblast-like synovial cell (HFLS) were stimulated by TNF- in the presence or the absence of 3-methyladenine (3-MA) or chloroquine (CQ). Read More

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October 2018
1 Read

Pseudogout: An Autoimmune Paraneoplastic Manifestation of Myelodysplastic Syndrome.

Cureus 2018 Sep 27;10(9):e3372. Epub 2018 Sep 27.

Internal Medicine, University at Buffalo / Sisters of Charity Hospital, Buffalo, USA.

Myelodysplastic syndrome (MDS) is often associated with autoimmune paraneoplastic manifestations. Seronegative arthritis is among one of them. Very rarely, pseudogout demonstrated as paraneoplastic autoimmune manifestations of MDS has been adumbrated so far. Read More

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September 2018
3 Reads

Targeting Regulation of Cyclin Dependent Kinase 9 as a Novel Therapeutic Strategy in Synovial Sarcoma.

J Orthop Res 2018 Nov 28. Epub 2018 Nov 28.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA.

Synovial sarcomas hold a low genomic complexity, making it distinct from other types of soft-tissue sarcomas. Many studies focused on targeting the SS18-SSX fusion protein, which presents in over 90% of human synovial sarcomas. This protein acts as an oncogenic promoter in the tumorigenesis of synovial sarcomas, making it an ideal therapeutic target. Read More

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November 2018
2 Reads

A Two Compartment Pharmacokinetic Model Describes the Intra-articular Delivery and Retention of rhPRG4 Following ACL Transection in the Yucatan Mini Pig.

J Orthop Res 2018 Nov 28. Epub 2018 Nov 28.

Department of Emergency Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA.

Treatment of the injured joint with rhPRG4 is based on recent observations that inflammation diminishes expression of native PRG4. Re-establishing lubrication between pressurized and sliding cartilage surfaces during locomotion promotes the nascent expression of PRG4 and thus intra-articular (IA) treatment strategies should be supported by pharmacokinetic evidence establishing the residence time of rhPRG4. A total of 21 Yucatan minipigs weighing ∼55 Kg each received 4 mg of I-rhPRG4 delivered by IA injection 5 days following surgical ACL transection. Read More

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November 2018
1 Read

Patient-reported outcomes and safety in patients undergoing synovial biopsy: comparison of ultrasound-guided needle biopsy, ultrasound-guided portal and forceps and arthroscopic-guided synovial biopsy techniques in five centres across Europe.

RMD Open 2018 26;4(2):e000799. Epub 2018 Oct 26.

Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, UK.

Background: We present a European multicenter study, comparing safety data and patient-reported outcomes (PRO) from patients undergoing synovial biopsy using ultrasound-guided needle biopsy (US-NB), ultrasound-guided portal and forceps (US-P&F) or arthroscopic-guided (AG) procedures.

Objectives: To describe safety and PRO data on joint indices of pain, stiffness and swelling before and after biopsy, procedural discomfort, joint status compared with before biopsy and willingness to undergo a second biopsy for each technique and compare the three techniques. To evaluate the impact on PRO and safety data of corticosteroid therapy as part of the biopsy procedure and sequential biopsy procedures. Read More

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October 2018
1 Read

[Secondary osteoporosis. Bone metabolic disorder in Rheumatoid arthritis.]

Clin Calcium 2018 ;28(12):1599-1603

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

Rheumatoid arthritis(RA)is an immune-mediated disease marked by chronic synovial inflammation, which leads to cartilage and bone destruction as well as systemic bone loss. Osteoporosis or the systemic bone loss associated with RA increases the risk for fragility fractures, which can affect quality of life dramatically in RA patients. Inflammatory cytokines such as TNF and IL-6 in inflamed synovium induce the differentiation of osteoclasts, while suppresses the differentiation of osteoblasts, resulting in imbalance in bone metabolism. Read More

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January 2018

In vitro and in vivo potentialities for cartilage repair from human advanced knee osteoarthritis synovial fluid-derived mesenchymal stem cells.

Stem Cell Res Ther 2018 Nov 28;9(1):329. Epub 2018 Nov 28.

UMR 7365 CNRS-UL, IMoPA (Ingénierie Moléculaire et Physiopathologie Articulaire), Biopôle de l'Université de Lorraine, Campus Brabois-Santé, 9 Avenue de la Forêt de Haye, BP 20199, 54505, Vandœuvre-Lès-Nancy, France.

Background: Mesenchymal stem cells (MSCs) are found in synovial fluid (SF) and can easily be harvested during arthrocentesis or arthroscopy. However, SF-MSC characterization and chondrogenicity in collagen sponges have been poorly documented as well as their hypothetical in vivo chondroprotective properties with intra-articular injections during experimental osteoarthritis (OA).

Methods: SF-MSCs were isolated from human SF aspirates in patients suffering from advanced OA undergoing total knee joint replacements. Read More

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November 2018
1 Read

Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation: Does proteoglycan 4 have the ability to buffer the inflammatory response?

Bioessays 2018 Nov 28:e1800166. Epub 2018 Nov 28.

McCaig institute for Bone and Joint Health, University of Calgary, Calgary, Alberta T2N4N1, Canada.

Proteoglycan 4 (PRG4), first identified in synovial fluid, is an extracellular matrix structural protein in the joint implicated in reducing shear at the cartilage surface as well as controlling adhesion-dependent synovial growth and regulating bulk protein deposition onto the cartilage. However, recent evidence suggests that it can bind to and effect downstream signaling of a number of cell surface receptors implicated in regulating the inflammatory response. Therefore, we pose the hypothesis: Does PRG4 regulate the inflammatory response and maintain tissue homeostasis? Based on these novel findings implicating PRG4 as an inflammatory signaling molecule, we will present and discuss several hypotheses regarding potential mechanisms by which PRG4 may be able to regulate inflammation. Read More

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November 2018

Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis.

PLoS One 2018 28;13(11):e0206217. Epub 2018 Nov 28.

Translational Musculoskeletal Research Center, Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States of America.

Objective: CD14 is a monocyte/macrophage pattern-recognition receptor that modulates innate inflammatory signaling. Soluble CD14 levels in knee OA synovial fluids are associated with symptoms and progression of disease. Here we investigate the role of this receptor in development of OA using a murine joint injury model of disease. Read More

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November 2018
3 Reads

Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy.

FASEB J 2018 Nov 28:fj201801851R. Epub 2018 Nov 28.

Department of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Osteoarthritis (OA) is a disease characterized by cartilage damage and abnormal remodeling of subchondral bone. Our previous study showed that in the early stage of OA, knee loading exerts protective effects by suppressing osteoclastogenesis through Wnt signaling, but little is known about loading effects at the late OA stage. Endoplasmic reticulum (ER) stress and autophagy are known to be involved in the late OA stage. Read More

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November 2018

Aortic saddle embolism following pneumonectomy for synovial sarcoma of lung.

ANZ J Surg 2018 Nov 28. Epub 2018 Nov 28.

Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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November 2018

Radiological features of synovial chondromatosis affecting the temporomandibular joint: report of three cases.

Oral Radiol 2018 Aug 23. Epub 2018 Aug 23.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Ren Min Nan Lu, Chengdu, Sichuan, 610041, China.

Synovial chondromatosis is a benign nodular cartilaginous proliferation that mainly occurs in large joints. The temporomandibular joint is considered to be rarely affected. Several cases of synovial chondromatosis of the temporomandibular joint have been reported with clinical and histological features. Read More

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August 2018
2 Reads

Study of the mechanism underlying hsa-miR338-3p downregulation to promote fibrosis of the synovial tissue in osteoarthritis patients.

Mol Biol Rep 2018 Nov 27. Epub 2018 Nov 27.

Department of Orthopaedics, Yancheng City No. 1 People's Hospital, Yancheng, 224006, China.

Osteoarthritis (OA) is a degenerative joint disease characterized by the degradation of joint cartilage, the formation of osteophyma at joint margins, and synovial changes. Whereas lesions of the joint cartilage were the key point of the research and treatment of osteoarthritis before, a recent study showed that the synovium plays a crucial role in the pathological progress of OA. The inflammatory environment in the joints of OA patients always results in the overactivation of fibroblast-like synoviocytes (FLSs), which produce a multitude of inflammatory factors and media, not only leading to the degradation and injury of the cartilage tissue and promoting the development of osteoarthritis but also resulting in synovial fibrosis and joint stiffness. Read More

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November 2018
2 Reads

Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genome‑wide gene expression profiling analysis.

Mol Med Rep 2018 Nov 20. Epub 2018 Nov 20.

School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of The National Health and Family Planning Commission, Xi'an, Shaanxi 710061, P.R. China.

The present study aimed to identify potential novel biomarkers in synovial tissue obtained from patients with Rheumatoid Arthritis (RA) and Osteoarthritis (OA) for differential diagnosis. The genome‑wide expression profiling datasets of synovial tissues from RA and OA cohorts, including GSE55235, GSE55457 and GSE55584 datasets, were retrieved and used to identify differentially expressed genes (DEGs; P<0.05; false discovery rate <0. Read More

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November 2018

Extracellular Vesicles in Joint Disease and Therapy.

Front Immunol 2018 12;9:2575. Epub 2018 Nov 12.

Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.

The use of extracellular vesicles (EVs) as a potential therapy is currently explored for different disease areas. When it comes to the treatment of joint diseases this approach is still in its infancy. As in joint diseases both inflammation and the associated articular tissue destruction are important factors, both the immune-suppressive and the regenerative properties of EVs are potentially advantageous characteristics for future therapy. Read More

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November 2018

What's in a name? A call for consistency in the classification of tenosynovial giant cell tumour.

Knee 2018 Dec 25;25(6):1322-1323. Epub 2018 Oct 25.

IRCCS Istituto Ortopedico Galeazzi, Via Riccardo Galeazzi, 4, 20161 Milan, Italy.

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December 2018

Laryngeal synovial sarcoma: Report of 2 cases.

J Egypt Natl Canc Inst 2018 Dec 24;30(4):173-176. Epub 2018 Nov 24.

ENT Department, Farhat Hached University Hospital, Sousse, Tunisia.

Synovial sarcoma is a malignant mesenchymal tumor. It most commonly occurs in the lower extremities of young adults. The head and neck are rare sites, accounting for less than 10%. Read More

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December 2018
3 Reads

The Cliff Sign: A New Radiographic Sign of Hip Instability.

Orthop J Sports Med 2018 Nov 12;6(11):2325967118807176. Epub 2018 Nov 12.

Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, California, USA.

Background: The preoperative diagnosis of hip microinstability is challenging. Although physical examination maneuvers and magnetic resonance imaging findings associated with microinstability have been described, there are limited reports of radiographic features. In patients with microinstability, we observed a high incidence of a steep drop-off on the lateral edge of the femoral head, which we have named the "cliff sign. Read More

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November 2018

Recently highlighted nutraceuticals for preventive management of osteoarthritis.

World J Orthop 2018 Nov 18;9(11):255-261. Epub 2018 Nov 18.

Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Catania 95123, Italy.

Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage with limited treatment options. This reality encourages clinicians to suggest preventive measures to delay and contain the outbreak of the pathological conditions. Articular cartilage and synovium suffering from OA are characterised by an inflammatory state and by significant oxidative stress, responsible for pain, swelling and loss of mobility in the advanced stages. Read More

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November 2018
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