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Int J Surg Case Rep 2022 May 31;96:107265. Epub 2022 May 31.

Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province 250025, China. Electronic address:

Prostate synovial sarcoma (SS) is extremely rare. We report a case of prostate SS diagnosed using fine-needle biopsy. The following findings were found: The serum prostate specific antigen level was low, magnetic resonance imaging shows an irregular soft tissue mass in the right posterior part of the prostate, and computed tomography examinations did not reveal any tumor at other parts of the body. Read More

Pharmaceuticals (Basel) 2022 May 24;15(6). Epub 2022 May 24.

Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, Idaho State University, Pocatello, ID 83209, USA.

Synovial sarcoma (SS) is a pediatric muscle cancer that primarily affects adolescents and young adults and has few treatment options. Complicating the treatment of synovial sarcoma is the low mutational burden of SS. Inflammatory pathways have been identified as being upregulated in some SS, leading to the discovery of upregulated oncostatin M receptor (OSMR). Read More

Front Oncol 2022 6;12:873323. Epub 2022 Jun 6.

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Although clinicians and patients with extremity bone and soft tissue (EBST) are increasingly interested in limb salvage surgery (LSS), because of the minimal damage to physical appearance and function, however, there is still a lack of large-scale population studies on whether LSS improves the prognosis of patients.

Purpose: The aim of this study was to compare the survival of patients with EBST sarcomas after receiving LSS and amputation.

Methods: To conduct the population-based study, we identified 6,717 patients with a histologically diagnosed bone sarcoma and 24,378 patients with a histologically diagnosed soft tissue sarcoma from the Surveillance, Epidemiology, and End Results database. Read More

Clin Cancer Res 2022 Jun 21. Epub 2022 Jun 21.

The University of Texas MD Anderson Cancer Center, Houston, Texas, United States.

Understanding metabolic dependencies and their therapeutic vulnerabilities are key to precision oncology. Malic enzyme1 (ME1) is frequently overexpressed in cancers with pro-tumorigenic effects. In contrast, consistent loss of ME1 expression in synovial sarcoma compared with other sarcomas indicates a unique ferroptosis liability for precision therapy in this form of cancer. Read More

Onco Targets Ther 2022 14;15:669-679. Epub 2022 Jun 14.

Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, Beijing, 100035, People's Republic of China.

Objective: To analyze the effectiveness of the long-term (> 12 months) administration of anlotinib as a monotherapy or combined therapy in patients with advanced sarcomas.

Methods: A retrospective analysis was conducted of patients with advanced sarcomas with measurable target lesions since 2018. Twenty-two of the patients had taken anlotinib regularly for > 12 months. Read More

Comput Intell Neurosci 2022 10;2022:4748628. Epub 2022 Jun 10.

Department of Orthopedics, The Fifth People's Hospital of Chengdu, Sichuan 611130, Chengdu, China.

Background: Synovial sarcoma is a rare disease, and synovial sarcoma that first appears in the extremities accounts for more than 80% of cases. We established two nomograms to predict the overall survival (OS) and cancer-specific survival (CSS) rates of patients with synovial sarcoma.

Methods: A total of 227 patients diagnosed with synovial sarcoma in the extremities between 2010 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Read More

Surg Oncol Clin N Am 2022 Jul;31(3):547-558

Department of Radiotherapy at the Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Radiotherapy at the Leiden University Medical Center, Leiden, the Netherlands.

Synovial sarcoma and myxoid liposarcoma are translocation-related sarcomas, with a high risk of developing distant metastasis, which often affect young patients and which are sensitive to chemo and radiotherapy. Surgery is the mainstay of therapy in localized disease. In these entities, perioperative radiotherapy is frequently administered, and chemotherapy is evaluated in patients with high-risk limb/trunk wall tumors in which an advantage in overall survival has been shown in the latest clinical trials. Read More

Surg Oncol Clin N Am 2022 Jul;31(3):381-397

Department of Medical Oncology, Centre Leon Berard, 28 rue Laennec, Lyon 69008, France.

Early experiences with modern immunotherapy have been disappointing in trials of unselected sarcoma subtypes. However, remarkable efficacy has been observed with immune checkpoint inhibitors (ICIs) in a subset of patients, with the most promising outcomes to date in alveolar soft part sarcoma, cutaneous angiosarcoma, undifferentiated pleomorphic sarcoma (UPS), and dedifferentiated liposarcoma (dLPS). Adoptive cellular therapies targeting cancer testis antigens have shown promising activity, but only synovial sarcoma (SS) and myxoid/round cell liposarcomas reliably express these targets. Read More

Turk Neurosurg 2021 Dec 22. Epub 2021 Dec 22.

Umraniye Education and Research Hospital, Department of Pathology, Istanbul, Turkey.

Aim: The spinal canal frequently harbors primary and secondary bone tumors. These tumors have specific localization, age range, and clinical and radiological manifestations, and their treatment requires a multidisciplinary approach. In most cases, a definitive diagnosis is made based on clinical, radiological, and histopathological findings. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2022 Jun;36(6):766-769

Department of Trauma and Microreconstructive Surgery, Orthopaedic Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.

Objective: To investigate the effectiveness of free transverse gracilis myocutaneous flap for soft tissue defects of foot and ankle.

Methods: Between January 2017 and December 2020, 16 cases (17 feet) of soft tissue defects of foot and ankle were repaired with free transverse gracilis myocutaneous flaps. There were 10 males and 6 females, with an average age of 38 years (range, 23-60 years). Read More

Am J Transl Res 2022 15;14(5):2894-2909. Epub 2022 May 15.

University of New South Wales, St. George & Sutherland Clinical School Sydney, NSW 2217, Australia.

Single-agent doxorubicin currently forms part of standard care for patients with sarcomas. However, efficacy is limited by the presence of dose-dependent cardiotoxicity and toxicity to renal, hepatic, and neurological systems. Therefore, there is a pressing need for novel drug regimens which can provide increased efficacy and safety. Read More

Future Cardiol 2022 Jun 14. Epub 2022 Jun 14.

Clinical Research Development Center, Shahid Modarres Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, 1998734383, Iran.

Primary cardiac synovial sarcoma is a very rare primary cardiac tumor that usually arises in the right side of the heart. Brain metastases in primary cardiac sarcomas are not uncommon. Because of the wild nature of these tumors, they usually have poor outcomes. Read More

Acta Oncol 2022 Jul 13;61(7):793-800. Epub 2022 Jun 13.

Department of Oncology, Oslo University Hospital, Oslo, Norway.

Background: Data from the real-world setting on perioperative chemotherapy in high-risk, localized soft tissue sarcoma (STS) is limited. Real-world data (RWD) includes data derived from patients treated outside clinical trials and often captures long-term follow-up not recorded in clinical trials. The aim of this study was to provide population-based, real-world evidence on perioperative chemotherapy in localized STS. Read More

Pathology 2022 Jun 10. Epub 2022 Jun 10.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

Mixed epithelial and stromal tumour of the kidney is a complex benign neoplasm in which malignancy rarely arises. In this study, we report four mixed epithelial and stromal tumours in which sarcoma or carcinoma developed. In the first, a multifocal adenocarcinoma arose and areas of transition from benign to malignant epithelium were observed. Read More

Foot Ankle Int 2022 Jun 13:10711007221097654. Epub 2022 Jun 13.

Department of Orthopedics and Traumatology, Ankara University, Ankara, Turkey.

Background: Surgical treatment is usually required for malignant foot and ankle tumors. In this study, we sought to review factors in treatment that may be associated with morbidity and mortality.

Methods: All malignant foot and ankle tumors at our institution between April 1988 and April 2018 were retrospectively reviewed. Read More

Front Oncol 2022 25;12:864790. Epub 2022 May 25.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States.

Objective: Children and adolescents with recurrent and metastatic solid tumors have a poor outcome. A previous phase 1 study (ANGIO1) targeting angiogenesis with bevacizumab, sorafenib, and cyclophosphamide, demonstrated a signal of activity in a subset of patients. Here we report the results of a cohort of pediatric and young adult patients treated at the recommended phase 2 doses. Read More

Eur J Nucl Med Mol Imaging 2022 Jun 11. Epub 2022 Jun 11.

Department of Nuclear Medicine, The Third Hospital, Hebei Medical University, No. 139, Ziqiang Road, Shijiazhuang, 050051, Hebei, People's Republic of China.

J Cancer Res Clin Oncol 2022 Jun 10. Epub 2022 Jun 10.

Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart, Olgahospital, Stuttgart, Germany.

Purpose: Optimization of local therapies in synovial sarcoma (SS) considered unresectable at diagnosis is needed. We evaluated the effects of neoadjuvant versus adjuvant radiation versus surgery only on long-term outcomes.

Methods: Patients with macroscopic SS tumors before chemotherapy (IRS-group-III) in the trials CWS-81, CWS-86, CWS-91, CWS-96, CWS-2002-P and SoTiSaR-registry were analyzed. Read More

Zhonghua Bing Li Xue Za Zhi 2022 Jun;51(6):518-523

Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To explore the clinicopathological features, immunophenotype and molecular genetic characteristics of malignant solitary fibrous tumor (MSFT). Seven cases of MSFT were collected from the First Affiliated Hospital of Zhengzhou University from July 2018 to December 2020. Immunohistochemistry, RNA-based NGS and DNA-based NGS were performed. Read More

Eur J Surg Oncol 2022 Jun 2. Epub 2022 Jun 2.

Division of Medical Oncology, Department of Medicine, University of Ottawa, Ottawa, ON, K1N 6N5, Canada; Division of Medical Oncology, The Ottawa Hospital Cancer Centre, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada; Ottawa Hospital Research Institute, Ottawa, ON, K1Y 4E9, Canada. Electronic address:

Background: Synovial sarcoma (SS) is a malignancy with high metastatic potential. The role of metastasectomy in SS is unclear, with limited data on prognostic factors and clinical outcomes. In this systematic review, we evaluate the survival outcomes post-metastasectomy for patients with SS. Read More

Cancer Med 2022 Jun 7. Epub 2022 Jun 7.

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA.

Background: Synovial sarcoma (SS) accounts for 8%-10% of all soft-tissue sarcomas. Clinical presentation and outcomes vary, yet discrete risk groups based on validated prognostic indices are not defined for the full spectrum of patients with SS.

Methods: We performed a retrospective cohort study using data from the SEER (surveillance, epidemiology, and end results program) database of SS patients who were <70 years of age at diagnosis. Read More

J Surg Oncol 2022 Jun 7. Epub 2022 Jun 7.

Department of Orthopaedics and Trauma Surgery, University of Pisa, Pisa, Italy.

Background: Synovial sarcoma is a rare malignant tumor that generally requires a multidisciplinary therapeutic approach. In this study we report the experience of a single surgeon, evaluating surgical and oncological outcomes of the cases he treated through his 30 years carrier.

Methods: We enrolled patients treated surgically between 1988 and 2018. Read More

ANZ J Surg 2022 Jun 6. Epub 2022 Jun 6.

General Surgery, Albury Wodonga Health, Albury, New South Wales, Australia.

Front Genet 2022 18;13:834445. Epub 2022 May 18.

Ludwig Institute for Cancer Research, Memorial Sloan Kettering Institute for Cancer Research, New York City, NY, United States.

Here we describe the identification of genes and their encoded proteins that are expressed in advanced grade tumors by reconstruction of a sarcoma cancer testis gene 1b/a () network. CTAG1B/A is an ortholog of the yeast/Drosophila transcription factor Pcc1p, and a member of the KEOPS transcription complex. It has been implicated in telomere maintenance and transcriptional regulation through association with chromatin remodeling factors and is only expressed during adult testis germ cell differentiation. Read More

Diagn Pathol 2022 Jun 2;17(1):49. Epub 2022 Jun 2.

Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, 130000, China.

Background: Synovial sarcoma is a soft tissue sarcoma of temporarily unknown histologic origin with the ability for biphasic differentiation, occurring mostly in the vicinity of large joints of the extremities. Synovial sarcoma that originates in the liver is extremely rare. Only 7 cases have been reported in the domestic and international literature. Read More

Hum Cell 2022 Jul 2;35(4):1290-1297. Epub 2022 Jun 2.

Division of Rare Cancer Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Synovial sarcoma (SS) is a rare and aggressive mesenchymal malignancy driven by a unique chromosomal translocation that generates the expression of the SS18:SSX fusion protein. It occurs at almost any anatomical site and most commonly in young adults. The standard curative treatment for primary SS is a wide surgical resection combined with radiotherapy and/or neoadjuvant chemotherapy. Read More

Curr Probl Diagn Radiol 2022 May 2. Epub 2022 May 2.

Department of Radiology, Temple University Health System, 3401 N. Broad St, Philadelphia, PA 19140, United States.

Soft tissue sarcomas are a rare diverse group of mesenchymal malignancies that can arise in any location in the body and have extremely variable presentations. Liposarcoma, pleomorphic undifferentiated sarcoma, leiomyosarcoma, myxofibrosarcoma, and synovial sarcoma constitute 75% of all soft tissue sarcomas. These along with more uncommon sarcomas will be reviewed with emphasis on the 2013 World Health Organization (WHO) classification. Read More

Cureus 2022 Apr 25;14(4):e24457. Epub 2022 Apr 25.

Orthopaedic Surgery, Johns Hopkins University, Baltimore, USA.

Primary intra-articular sarcomas are rare and present with nonspecific symptoms such as pain or swelling. Due to nonspecific symptoms, patients may undergo routine diagnostic arthroscopy, which ultimately leads to sarcoma diagnosis. Here we present four patients with intra-articular sarcomas of the knee diagnosed after arthroscopy. Read More

Genes Chromosomes Cancer 2022 May 31. Epub 2022 May 31.

Department of Pathology and Laboratory Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio.

SS18::SSX gene fusions as a result of t(X,18)(p11;q11) have only been described in synovial sarcoma (SS). Recently, an SS18::NEDD4 gene fusion was identified in a single case of primary renal SS exhibiting a hypocellular and myxoid morphology. Herein, we report a case of an unclassified malignant cutaneous spindled and epithelioid neoplasm in a 60-year-old female that resembled an epithelioid sarcoma (ES) and harbored a rare SS18::NEDD4 gene fusion. Read More

Int J Surg Case Rep 2022 Jun 24;95:107243. Epub 2022 May 24.

Department of Trauma Surgery and Orthopaedics, Ibn Rochd University Hospital Center, Casablanca, Morocco; Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.

Introduction: Synovial sarcoma is a rare and aggressive soft tissue tumor that affects the para-articular regions of the large joints. It originates from mesenchymal cells with synovial differentiation. Its management remains surgical with wide excision. Read More