1,959 results match your criteria Synovial Cell Sarcoma


Primary Renal Sarcoma With Gene Fusion in an 18-Year-Old Male: A Rare Lesion With a Diagnostic Quandary.

Int J Surg Pathol 2020 Jul 10:1066896920941087. Epub 2020 Jul 10.

Department of Pathology, UT Southwestern Medical Center, Dallas TX, USA.

Primary renal sarcoma with gene fusion is a rare tumor with only 7 cases reported in the English literature. The morphologic features of this tumor strikingly overlap with clear cell sarcoma of the kidney and synovial sarcoma. Accurate diagnosis can be challenging. Read More

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http://dx.doi.org/10.1177/1066896920941087DOI Listing

SWI/SNF complex-deficient soft tissue neoplasms: An update.

Semin Diagn Pathol 2020 Jun 5. Epub 2020 Jun 5.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

The SWItch Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex is a large multi-subunit protein assembly that orchestrates chromatin compaction and accessibility for gene transcription in an ATP-dependent manner. As a key epigenetic regulator, the SWI/SNF complex coordinates gene expression, cell proliferation and differentiation, and its biologic functions, in part, antagonize the polycomb repressive complex 2. The mammalian SWI/SNF complex consists of 15 subunits encoded by 29 genes, some of which are recurrently mutated in human cancers, in the germline or sporadic setting. Read More

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http://dx.doi.org/10.1053/j.semdp.2020.05.005DOI Listing

Skp2 Depletion Reduces Tumor-Initiating Properties and Promotes Apoptosis in Synovial Sarcoma.

Transl Oncol 2020 Jul 2;13(10):100809. Epub 2020 Jul 2.

Department of Orthopedic Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY. Electronic address:

Synovial sarcoma (SS) is an aggressive soft-tissue cancer with a poor prognosis and a propensity for local recurrence and distant metastasis. In this study, we investigated whether S phase kinase-associated protein (Skp2) plays an oncogenic role in tumor initiation, progression, and metastasis of SS. Our study revealed that Skp2 is frequently overexpressed in SS specimens and SS18-SSX transgenic mouse tumors, as well as correlated with clinical stages. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100809DOI Listing

Incidence, treatment, and outcomes of primary and recurrent Non-Wilms renal tumors in children: Report of 109 patients treated at a single institution.

J Pediatr Urol 2020 Jun 5. Epub 2020 Jun 5.

Homi Bhabha National Institute (HBNI), Mumbai, India; Department of Nuclear Medicine, Tata Memorial Centre, Bombay, India.

Introduction: Non-Wilms renal tumors represent a compelling subset of childhood renal tumors. However, their relative rarity renders accurate diagnosis, and therapy challenging which in some instance is inferred from their adult counterparts.

Objective: To describe the incidence and analyze the diagnostic challenges, therapies and, outcomes of non-Wilms renal tumors at the largest tertiary cancer centre in India. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.05.168DOI Listing

Epidemiology, incidence, and survival of synovial sarcoma subtypes: SEER database analysis.

J Orthop Surg (Hong Kong) 2020 Jan-Apr;28(2):2309499020936009

Department of Orthopedics and Traumatology, Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey.

Background: Synovial sarcoma (SyS) is a rare malignancy that is typically located on the limbs and occurs predominantly in adolescents. A study in a large population for SyS comparing subtypes has not yet been reported.

Methods: National Cancer Institute's Surveillance, Epidemiology, and End Results database was queried for patients diagnosed with SyS between January 1975 and December 2016. Read More

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http://dx.doi.org/10.1177/2309499020936009DOI Listing

-Positive Fibroblastic Tumor.

Int J Surg Pathol 2020 Jul 3:1066896920938124. Epub 2020 Jul 3.

The Royal Marsden, London, UK.

-positive fibroblastic tumor is a recently characterized neoplasm with distinct clinicopathologic features and recurrent gene fusion. ESFT typically presents as a small, painless tumor in extremity subcutaneous tissues. Their behavior is benign, although they are prone to local recurrence. Read More

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http://dx.doi.org/10.1177/1066896920938124DOI Listing

Facts and hopes in immunotherapy of soft tissue sarcomas.

Clin Cancer Res 2020 Jun 29. Epub 2020 Jun 29.

Internal Medicine, Washington University in St. Louis

Sarcomas are mesenchymal tumors, encompassing more than 175 subtypes, each one with their own genetic complexities. As a result, immunotherapy approaches have not been universally successful across the wide rage of diverse subtypes. The actual state of science and the current clinical data utilizing immunotherapy within the soft tissue sarcomas (STS) will be detailed in this review. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-19-3335DOI Listing

The Diagnostic and Clinical Significance of TFE3 Immunohistochemical Nuclear Expression in Solitary Fibrous Tumour.

Anal Cell Pathol (Amst) 2020 28;2020:8232803. Epub 2020 May 28.

Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

The expression of TFE3 (transcription factor E3) in solitary fibrous tumours (SFTs) and their histologic mimickers was investigated, and the diagnostic value and clinical significance of TFE3 nuclear expression in SFTs were explored. Immunohistochemical analysis for TFE3 was performed on 50 cases of SFTs that were surgically resected. The controls were sample tissues from malignant peripheral nerve sheath tumour, synovial sarcoma, dedifferentiated liposarcoma, spindle cell lipoma, and dermatofibrosarcoma protuberans. Read More

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http://dx.doi.org/10.1155/2020/8232803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275214PMC

Undifferentiated round cell sarcomas with novel SS18-POU5F1 fusions.

Genes Chromosomes Cancer 2020 Jun 17. Epub 2020 Jun 17.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

Despite significant recent advances in characterizing the molecular pathogenesis of undifferentiated round cell neoplasms, rare cases remain unclassified. Here, we report two distinctive undifferentiated round cell tumors occurring in young adults. One tumor presented intrabdominally and the other arose within the abdominal wall. Read More

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http://dx.doi.org/10.1002/gcc.22879DOI Listing

Malignant Round Cell Tumor with SS18-POU5F1 Fusion: Is it a Myoepithelial Neoplasm, a Synovial Sarcoma or a New Entity?

Histopathology 2020 Jun 9. Epub 2020 Jun 9.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, United States.

Recent advances in clinical molecular diagnostics have improved the classification of round cell sarcomas with Ewing morphology that do not harbor classic EWSR1/FUS rearrangements. Some such "Ewing-like" sarcomas are now recognized as distinct entities including BCOR-rearranged sarcomas, CIC-rearranged sarcomas, EWSR1-rearranged tumors involving non ETS family fusions in myoepithelial neoplasms of soft tissue and others (1). However, it is widely recognized that some remain unclassified to this date (1). Read More

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http://dx.doi.org/10.1111/his.14171DOI Listing

Primary Cutaneous Synovial Sarcoma - Sometimes the Hoof Beats are Zebras.

J Cutan Pathol 2020 Jun 8. Epub 2020 Jun 8.

Department of Pathology, Cleveland Clinic, Cleveland Ohio.

Synovial sarcoma accounts for 5-10% of soft tissue sarcoma and typically presents as a deep soft tissue mass. Primary cutaneous presentation is exceptionally rare, with only isolated case reports. We report a case of primary cutaneous synovial sarcoma in a 58-year-old woman that presented as a nodule involving the left occipital scalp. Read More

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http://dx.doi.org/10.1111/cup.13766DOI Listing

Dark as night: Spelunking for spinal solitary fibrous tumors/hemangiopericytomas in the differential of T2 hypointensity.

J Clin Neurosci 2020 Jun 4. Epub 2020 Jun 4.

Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Radiology, Mayo Clinic, Rochester MN, USA. Electronic address:

Spinal solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a rare mesenchymal malignancy. Radiographically, SFT/HPCs have a mutable appearance, with irregular borders, heterogeneous contrast enhancement, and variable but frequently hypointense T2 signal. We report a series of 5 neurosurgically managed spinal SFT/HPCs treated at our institution, with particular attention to 3 lesions demonstrating marked T2-hypointensity and differential diagnosis for the unusual finding of a "T2 dark" spinal lesion. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.05.051DOI Listing

Treatment of limb synovial sarcoma with metastasis at presentation.

Medicine (Baltimore) 2020 Jun;99(23):e20550

Department of Orthopaedics, First People's Hospital of Huzhou, First Affiliated Hospital of Huzhou University, Huzhou.

Limb synovial sarcoma (LSS) patients with metastasis at presentation usually have a very poor prognosis. Little is known about survival prediction and risk factors in these patients owing to the condition's rarity. Thus, this study examined the survival and prognostic variables of metastatic LSS. Read More

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http://dx.doi.org/10.1097/MD.0000000000020550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306353PMC

Effect of preoperative cancer treatment on epidermal growth factor receptor (EGFR) receptor expression level in ABY-029 guided sarcoma surgery.

Proc SPIE Int Soc Opt Eng 2020 Feb 19;11222. Epub 2020 Feb 19.

Orthopaedics, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755.

Surgical excision via wide local excision (WLE) of the primary sarcoma tumor is a mainstay of treatment due to the limited effectiveness of chemotherapy and radiation. Even with attempts at WLE, 22-34% of the patient will be diagnosed with a positive margin by the pathologist, necessitating additional radiation or surgery. Recent studies have demonstrated reduced local recurrence when using fluorescence-guided surgery (FGS) to detect residual sarcoma following attempted WLE. Read More

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http://dx.doi.org/10.1117/12.2546963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263172PMC
February 2020

Feasibility of Targeting Traf2-and-Nck-Interacting Kinase in Synovial Sarcoma.

Cancers (Basel) 2020 May 16;12(5). Epub 2020 May 16.

Laboratory of Collaborative Research, Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo 104-0045, Japan.

Background: The treatment of patients with metastatic synovial sarcoma is still challenging, and the development of new molecular therapeutics is desirable. Dysregulation of Wnt signaling has been implicated in synovial sarcoma. Traf2-and-Nck-interacting kinase (TNIK) is an essential transcriptional co-regulator of Wnt target genes. Read More

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http://dx.doi.org/10.3390/cancers12051258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281028PMC

Left Atrial High-grade Sarcoma With Focal Osteosarcomatous Differentiation.

Cureus 2020 Apr 13;12(4):e7660. Epub 2020 Apr 13.

Cardiology, Palmetto General Hospital, Hialeah, USA.

Approximately 75% of cardiac tumors are benign, and 25% are malignant cardiac tumors. Of these, sarcomas are extremely rare and have been described in isolated case reports. Due to its rarity, there is no published guideline for the management of this pathological entity. Read More

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http://dx.doi.org/10.7759/cureus.7660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219016PMC

Tumor mutation burden and checkpoint immunotherapy markers in primary and metastatic synovial sarcoma.

Hum Pathol 2020 Jun 5;100:15-23. Epub 2020 May 5.

Department of Pathology & Immunology, Washington University at St. Louis School of Medicine, St. Louis, MO, 63110, USA.

Synovial sarcoma (SS) is a soft-tissue malignancy that most often affects patients aged between 15 and 40 years, and the prognosis for patients with metastatic disease is generally poor. This study was performed to evaluate checkpoint blockade immunotherapy markers in SS, including tumor mutational burden (TMB), DNA mismatch repair (MMR) status, and PDL-1 (programmed cell death ligand 1), PD1 (programmed cell death 1), and CD8 expression by normal-tumor paired whole-exome sequencing (WES) and immunohistochemistry (IHC). Outcomes evaluated included event-free and overall survival. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.04.007DOI Listing

Synovial sarcoma presenting as an intra-articular mass in a pediatric patient: a case report.

BMC Musculoskelet Disord 2020 May 7;21(1):283. Epub 2020 May 7.

Department of Orthopaedics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Background: Synovial sarcoma (SS) is one of the reported sarcomas in the pediatric and adult populations. Delay in diagnosis and treatment is common in SS cases. SS may be excised before the correct diagnosis is made. Read More

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http://dx.doi.org/10.1186/s12891-020-03312-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206690PMC

Clinical outcomes of patients with advanced synovial sarcoma or myxoid/round cell liposarcoma treated at major cancer centers in the United States.

Cancer Med 2020 Jul 6;9(13):4593-4602. Epub 2020 May 6.

Mayo Clinic, Jacksonville, FL, USA.

Background: Outcomes data regarding advanced synovial sarcoma (SS) and myxoid/round cell liposarcoma (MRCL) are limited, consisting primarily of retrospective series and post hoc analyses of clinical trials.

Methods: In this multi-center retrospective study, data were abstracted from the medical records of 350 patients from nine sarcoma centers throughout the United States and combined into a registry. Patients with advanced/unresectable or metastatic SS (n = 249) or MRCL (n = 101) who received first-line systemic anticancer therapy and had records of tumor imaging were included. Read More

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http://dx.doi.org/10.1002/cam4.3039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333839PMC

Immunophenotype-Genotype Correlations in Clear Cell Sarcoma of Kidney-An Evaluation of Diagnostic Ancillary Studies.

Pediatr Dev Pathol 2020 May 4:1093526620910658. Epub 2020 May 4.

Trinity College, University of Dublin, Dublin, Ireland.

Introduction: The purpose of this study was to establish a reliable panel of antibodies for immunohistochemical corroboration of a diagnosis of clear cell sarcoma of kidney (CCSK), taking into consideration the various genotypic subsets of CCSK.

Methods: We conducted full genotypic analysis for evidence of internal tandem duplication (ITD), and in 68 archival cases of CCSK and then immunostained all cases for CCND1, TLE1, and BCOR along with 63 control samples representing tumor types that may enter into the differential diagnosis of CCSK, including 7 congenital mesoblastic nephromas, 2 desmoplastic small round cell tumors, 13 malignant rhabdoid tumors, 9 Ewing sarcomas/primitive neuroectodermal tumor, 5 synovial sarcomas, and 27 Wilms' tumors.

Results: Molecular assays showed that 54 CCSKs harbored a -ITD, 1 case expressed a fusion transcript while none expressed the fusion. Read More

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http://dx.doi.org/10.1177/1093526620910658DOI Listing

Primary Renal Mesenchymal Neoplasms in Nephrectomy Specimens: A 16-Year Survey of Primary and Incidental Cases From a Single Institution.

Int J Surg Pathol 2020 May 4:1066896920916780. Epub 2020 May 4.

Indiana University, Indianapolis, IN, USA.

. Primary renal mesenchymal neoplasms are rare but diverse. Several neoplasms of mesenchymal derivation can arise as a primary renal mass; however, incidental tumors are identified in nephrectomies performed for end-stage renal disease or other malignant epithelial renal neoplasms. Read More

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http://dx.doi.org/10.1177/1066896920916780DOI Listing
May 2020
0.961 Impact Factor

Primary cutaneous solitary fibrous tumor with entrapped eccrine components.

Authors:
Tien Anh N Tran

J Cutan Pathol 2020 Apr 20. Epub 2020 Apr 20.

Department of Pathology, Advent Health Orlando, Orlando, Florida, USA.

First described in the pleura, solitary fibrous tumor (SFT) was subsequently reported in a variety of organ systems. Compared to other anatomic sites, primary cutaneous and superficial SFTs are relatively rare. Although several histopathologic variants of cutaneous and superficial SFT have been described, a primary cutaneous SFT harboring glandular components has not hitherto been documented in the literature. Read More

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http://dx.doi.org/10.1111/cup.13717DOI Listing

Sarcoma metastasis to the pancreas: experience at a single institution.

J Pathol Transl Med 2020 May 22;54(3):220-227. Epub 2020 Apr 22.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Reports of metastatic sarcoma to the pancreas are limited. We reviewed the clinicopathologic characteristics of such cases.

Methods: We reviewed 124 cases of metastatic tumors to the pancreas diagnosed at Asan Medical Center between 2000 and 2017. Read More

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http://dx.doi.org/10.4132/jptm.2020.03.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253956PMC

Hydra: A mixture modeling framework for subtyping pediatric cancer cohorts using multimodal gene expression signatures.

PLoS Comput Biol 2020 04 10;16(4):e1007753. Epub 2020 Apr 10.

Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America.

Precision oncology has primarily relied on coding mutations as biomarkers of response to therapies. While transcriptome analysis can provide valuable information, incorporation into workflows has been difficult. For example, the relative rather than absolute gene expression level needs to be considered, requiring differential expression analysis across samples. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1007753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176284PMC

Establishment and characterization of NCC-SS3-C1: a novel patient-derived cell line of synovial sarcoma.

Hum Cell 2020 Jul 9;33(3):877-885. Epub 2020 Apr 9.

Division of Rare Cancer Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Synovial sarcoma is a rare malignancy of mesenchymal origin, characterized by a chromosomal translocation, t(X;18) (p11.2;q11.2). Read More

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http://dx.doi.org/10.1007/s13577-020-00354-6DOI Listing

Battle Against Musculoskeletal Tumors: Descriptive Data of Military Hospital Experience.

Front Public Health 2020 25;8:97. Epub 2020 Mar 25.

Department of Orthopaedics and Traumatology, Gulhane Training and Research Hospital, Ankara, Turkey.

Management of musculoskeletal tumors remains challenging for orthopedic surgeons. The aim of this cross-sectional study was to present the prevalence and localization of musculoskeletal disorders diagnosed and treated at a tertiary referral military hospital. A total of 552 patients' medical records who presented to our clinic between 2009 and 2014 with the diagnosis of musculoskeletal tumors were retrospectively analyzed according to age, gender, bone/soft tissue localization, histopathological diagnosis, incidence, and treatment. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109251PMC

Histiocyte predominant myocarditis resulting from the addition of interferon gamma to cyclophosphamide-based lymphodepletion for adoptive cellular therapy.

J Immunother Cancer 2020 Apr;8(1)

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Background: Adoptive cellular therapy (ACT) is a promising treatment for synovial sarcoma (SS) with reported response rates of over 50%. However, more work is needed to obtain deeper and more durable responses. SS has a 'cold' tumor immune microenvironment with low levels of major histocompatibility complex (MHC) expression and few T-cell infiltrates, which could represent a barrier toward successful treatment with ACT. Read More

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http://dx.doi.org/10.1136/jitc-2019-000247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254118PMC

Shoulder Tumor/Tumor-Like Lesions: What to Look for.

Magn Reson Imaging Clin N Am 2020 May;28(2):301-316

Department of Radiology, University of California San Diego, School of Medicine, UCSD Teleradiology and Education Center, 408 Dickinson Street, Mail Code #8226, San Diego, CA 92103-8226, USA.

This article discusses the most common tumor and tumor-like lesions arising at the shoulder. Osseous tumors of the shoulder rank second in incidence to those at the knee joint and include benign osteochondromas and myeloma or primary malignant lesions, such as osteosarcoma or chondrosarcomas. Soft tissue tumors are overwhelmingly benign, with lipomas predominating, although malignant lesions, such as liposarcomas, can occur. Read More

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http://dx.doi.org/10.1016/j.mric.2019.12.011DOI Listing

A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas.

Cancer Immunol Immunother 2020 Jul 28;69(7):1353-1362. Epub 2020 Mar 28.

Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians University Munich, Thalkirchner Str. 36, 80337, Munich, Germany.

Soft tissue sarcomas (STSs) are heterogeneous cancers associated with poor prognosis due to high rates of local recurrence and metastasis. The programmed death receptor ligand 1 (PD-L1) is expressed in several cancers. PD-L1 interacts with its receptor, PD-1, on the surface of tumor-infiltrating lymphocytes (TILs), thereby attenuating anti-cancer immune response. Read More

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http://dx.doi.org/10.1007/s00262-020-02552-5DOI Listing

The Value of H3K27me3 Immunohistochemistry in Differentiating Malignant Peripheral Nerve Sheath Tumour with Its Histologic Mimickers.

Asian Pac J Cancer Prev 2020 Mar 1;21(3):699-705. Epub 2020 Mar 1.

Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia.

Background: Diagnosis of malignant peripheral nerve sheath tumor (MPNST) is rather challenging due to its divergent morphologic heterogeneity and lack of specific ancillary test. The emergence of H3K27 trimethylation (H3K27me3) as a new immunohistochemistry (IHC) marker for MPNST have recently available to assist pathologists in differentiating MPNST from other histologic mimics. We aim to study the expression pattern of H3K27me3 in MPNST and its histologic mimickers and their association with the clinicopathological data. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.3.699DOI Listing

Impact of the Activation Status of the Akt/mTOR Signalling Pathway on the Clinical Behaviour of Synovial Sarcoma: Retrospective Analysis of 174 Patients at a Single Institution.

Cancer Manag Res 2020 9;12:1759-1769. Epub 2020 Mar 9.

Department of Pathology, Medical School of Chinese People's Liberation Army, Beijing 100853, People's Republic of China.

Purpose: Phosphoinositide 3-kinase (PI3K) and the downstream Akt/mammalian target of rapamycin (mTOR) pathway are central to the control of cell proliferation and survival. Although abnormal activation of this pathway has been well established in a variety of tumours, limited studies are available on synovial sarcoma. The aim of this study was to investigate the expression of several key proteins of those pathways in synovial sarcomas and to correlate the expression of these proteins with clinicopathologic features and prognosis. Read More

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http://dx.doi.org/10.2147/CMAR.S228578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074818PMC

Unusual Mimicker of the Carotid Body Tumor: Synovial Sarcoma of the Carotid Space.

J Craniofac Surg 2020 Jun;31(4):e397-e398

Department of Radiology, Ataturk University School of Medicine, Erzurum Turkey.

Synovial cell sarcomas are malignant tumors originating from pluripotent mesenchymal stem cells, unlike its name. It is a common tumor in the periarticular area, accounting for 8% of all soft tissue sarcomas. Head and neck are among the rarest areas of this tumor. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006365DOI Listing

Calcium-Dependent Calpain Activation-Mediated Mitochondrial Dysfunction and Oxidative Stress Are Required for Cytotoxicity of Epinecidin-1 in Human Synovial Sarcoma SW982 Cells.

Int J Mol Sci 2020 Mar 19;21(6). Epub 2020 Mar 19.

Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, 23-10 Dahuen Road, Jiaushi, Ilan 262204, Taiwan.

Synovial sarcoma is a rare but highly malignant and metastatic disease. Despite its relative sensitivity to chemotherapies, the high recurrence and low 5-year survival rate for this disease suggest that new effective therapeutic agents are urgently needed. Marine antimicrobial peptide epinecidin-1 (epi-1), which was identified from orange-spotted grouper (), exhibits multiple biological effects, including bactericidal, immunomodulatory, and anticancer activities. Read More

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http://dx.doi.org/10.3390/ijms21062109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139453PMC

Prominent entrapment of respiratory epithelium in primary and metastatic intrapulmonary non-epithelial neoplasms: a frequent morphological pattern closely mimicking adenofibroma and other biphasic pulmonary lesions.

Virchows Arch 2020 Mar 19. Epub 2020 Mar 19.

Institute of Pathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital, Krankenhausstrasse 8-10, 91054, Erlangen, Germany.

As one of the most common target organs for hematogenous spread from diverse cancers, biopsy interpretation of lung tumors is complicated by the challenging question of primary versus metastatic and by frequent entrapment of native respiratory glands. Nevertheless, the literature dealing with this issue is surprisingly sparse and no single study has been devoted to this topic. We reviewed 47 surgical lung specimens of non-epithelial neoplasms (38 metastases, mainly from sarcomas and 9 primary lesions) for frequency and pattern of intralesional epithelial entrapment. Read More

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http://dx.doi.org/10.1007/s00428-020-02796-7DOI Listing

A Novel SS18-SSX Fusion-specific Antibody for the Diagnosis of Synovial Sarcoma.

Am J Surg Pathol 2020 Jul;44(7):922-933

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School.

Synovial sarcoma (SS), an aggressive soft tissue sarcoma with a predilection for the extremities of young adults, harbors the pathognomonic t(X;18)(p11;q11) translocation, resulting in SS18-SSX rearrangements. SS includes monophasic, biphasic, and poorly differentiated variants, which show considerable histologic overlap with a range of other tumor types, making the diagnosis challenging on limited biopsies. Immunohistochemistry (IHC) is routinely used in the differential diagnosis; however, presently available markers lack specificity. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289668PMC

Intraarticular Nodular Fasciitis of the Knee With Fusion: A Case Report.

Int J Surg Pathol 2020 Feb 23:1066896920908054. Epub 2020 Feb 23.

Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.

. Nodular fasciitis (NF) is a self-limiting, benign mesenchymal neoplasm of fibroblastic/myofibroblastic origin. Due to the fast growth, cellularity, and frequently observed high mitotic count, it is commonly misdiagnosed as a sarcoma, often resulting in overtreatment. Read More

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http://dx.doi.org/10.1177/1066896920908054DOI Listing
February 2020

Giant cell tumour of tendon sheath mimicking nodal osteoarthritis.

BMJ Case Rep 2020 Feb 19;13(2). Epub 2020 Feb 19.

Internal Medicine, University of Florida, Gainesville, Florida, USA.

Giant cell tumour of the tendon sheath (GCTTS) commonly presents as a slow-growing and painless soft-tissue lesion in the hand. It has a propensity to mimick other benign and malignant lesions of the hand including lipoma, haemangioma, myxoid cyst, synovial sarcoma, aneurysmal bone cyst, fibroma and osteosarcoma. GCTTS has a unique histopathological appearance that aids in definitive diagnosis. Read More

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http://dx.doi.org/10.1136/bcr-2019-231902DOI Listing
February 2020

Soft-Tissue Tumors of the Hand-Imaging Features.

Can Assoc Radiol J 2020 May 22;71(2):161-173. Epub 2020 Jan 22.

Department of Radiology, University of Chicago, Chicago, IL, USA.

Imaging studies of the hands and fingers are common, and radiologists are generally comfortable with traumatic and degenerative conditions which arise frequently in daily practice. However, a variety of common and uncommon soft-tissue tumors also occur in the hand, the appropriate diagnosis of which can be a source of confusion for both clinicians and radiologists. These lesions often have overlapping imaging characteristics; however, a structured approach can help provide a focused differential diagnosis and impact further workup and management. Read More

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http://dx.doi.org/10.1177/0846537119888356DOI Listing

Cinematic rendering for three-dimensional reconstructions of the chest wall: a new reality.

Einstein (Sao Paulo) 2020 7;18:eMD5223. Epub 2020 Feb 7.

Cedars-Sinai S. Mark Taper Foundation Imaging Center, Los Angeles, CA, United States.

Computed tomography with multiple detectors and the advancement of processors improved rendered images and three-dimensional reconstructions in clinical practice. Traditional axial slices form non-intuitive images because they are seen in only one plane. The three-dimensional reconstructions can show structures details and diseases with complex anatomy in different perspectives. Read More

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http://dx.doi.org/10.31744/einstein_journal/2020MD5223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999188PMC

Clinicopathologic features of undifferentiated round cell sarcomas of bone & soft tissues: An attempt to unravel the & -positive sarcomas.

Indian J Med Res 2019 12;150(6):557-574

Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Background & Objectives: Certain genetically defined undifferentiated round cell sarcomas, namely BCOR-CCNB3 and CIC-DUX4 positive, have been described. Here we present detailed clinicopathologic features and molecular results in such cases.

Methods: Fifty one cases of undifferentiated round cell sarcomas, including 32 cases, tested for BCOR-CCNB3 and CIC-DUX4 fusions, by reverse transcription polymerase chain reaction technique and 44 tumours, for CCNB3 immunostaining, were analyzed. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_2144_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038815PMC
December 2019
1.661 Impact Factor

Uncommon tumors of temporomandibular joint: An institutional experience and review.

Head Neck 2020 Feb 10. Epub 2020 Feb 10.

Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas.

Background: The temporomandibular joint (TMJ) harbors a myriad of pathologic alterations including arthritides and benign and malignant neoplasms.

Methods: Herein, we describe our institutional experience of some uncommon and unusual synovial pathologies of the TMJ along with a review of literature. We searched through the archives of department of pathology and institutional electronic medical record for specimens of TMJ between 1999 and 2019. Read More

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http://dx.doi.org/10.1002/hed.26106DOI Listing
February 2020

NTRK3 overexpression in undifferentiated sarcomas with YWHAE and BCOR genetic alterations.

Mod Pathol 2020 Jul 7;33(7):1341-1349. Epub 2020 Feb 7.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

The BCOR family of tumors includes a number of undifferentiated sarcomas, occurring in various age groups and anatomic sites, characterized by a spindle and round cell phenotype and diffuse immunoreactivity for BCOR. Prior RNA sequencing data revealed that NTRK3 was a top-upregulated gene in BCOR-CCNB3 sarcomas. In this study, we investigate a large cohort of tumors harboring BCOR/YWHAE genetic alterations for NTRK3 upregulation at both the mRNA and protein levels, compared with other sarcoma types. Read More

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http://dx.doi.org/10.1038/s41379-020-0495-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329614PMC

Cooperation between SS18-SSX1 and miR-214 in Synovial Sarcoma Development and Progression.

Cancers (Basel) 2020 Jan 30;12(2). Epub 2020 Jan 30.

Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.

SS18-SSX fusion proteins play a central role in synovial sarcoma development, although, the genetic network and mechanisms of synovial sarcomagenesis remain unknown. We established a new ex vivo synovial sarcoma mouse model through retroviral-mediated gene transfer of into mouse embryonic mesenchymal cells followed by subcutaneous transplantation into nude mice. This approach successfully induced subcutaneous tumors in 100% recipients, showing invasive proliferation of short spindle tumor cells with occasional biphasic appearance. Read More

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http://dx.doi.org/10.3390/cancers12020324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072427PMC
January 2020

Diagnostic yield of NanoString nCounter FusionPlex profiling in soft tissue tumors.

Genes Chromosomes Cancer 2020 05 31;59(5):318-324. Epub 2020 Jan 31.

Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Diagnostic histopathology of soft tissue tumors can be troublesome as many entities are quite rare and have overlapping morphologic features. Many soft tissue tumors harbor tumor-defining gene translocations, which may provide an important ancillary tool for tumor diagnosis. The NanoString nCounter platform enables multiplex detection of pre-defined gene fusion transcripts in formalin-fixed and paraffin-embedded tissue. Read More

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http://dx.doi.org/10.1002/gcc.22834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079105PMC

Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target.

Cancers (Basel) 2020 Jan 14;12(1). Epub 2020 Jan 14.

Bayer AG, Innovation Campus Berlin, Research & Development, Pharmaceuticals, Muellerstrasse 178, D-13353 Berlin, Germany.

Inhibiting the interaction of menin with the histone methyltransferase MLL1 (KMT2A) has recently emerged as a novel therapeutic strategy. Beneficial therapeutic effects have been postulated in leukemia, prostate, breast, liver and in synovial sarcoma models. In those indications, MLL1 recruitment by menin was described to critically regulate the expression of disease associated genes. Read More

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http://dx.doi.org/10.3390/cancers12010201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016952PMC
January 2020

Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS).

J Cancer Res Clin Oncol 2020 Apr 13;146(4):953-960. Epub 2020 Jan 13.

Hospital for Children and Adolescents, Goethe-University, Frankfurt (Main), Germany.

Background: Older age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown.

Methods: SS patients < 21 years registered in consecutive CWS trials over the period of 1981-2018 were evaluated. Read More

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http://dx.doi.org/10.1007/s00432-019-03121-9DOI Listing