Search Our Scientific Publications & Authors

Children (Basel) 2021 Apr 10;8(4). Epub 2021 Apr 10.

Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

There are limited reports on the use of tolvaptan for syndrome of inappropriate antidiuretic hormone secretion (SIADH) in children. Managing serum sodium levels in SIADH patients during chemotherapy is often difficult because of the need for massive fluid infusions. We report the course of the use of tolvaptan for the treatment of hyponatremia during chemotherapy in a four-year-old girl with a suprasellar germ cell tumor. Read More

Zhonghua Er Ke Za Zhi 2021 May;59(5):419-421

Department of Pediatrics, the Second Hospital of Hebei Medical University, shijiazhuang 050000, China.

Cureus 2021 Mar 14;13(3):e13888. Epub 2021 Mar 14.

Department of Neurology, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Introduction Tuberculous meningitis (TBM) brings significant morbidity and mortality worldwide. Hyponatremia has long been documented as a potentially grave metabolic result of TBM. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been supposed to be accountable for the majority of cases of hyponatremia in TBM. Read More

J Psychopharmacol 2021 Apr 16:2698811211001082. Epub 2021 Apr 16.

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.

Background: Selective serotonin reuptake inhibitors (SSRIs) have a wide and increasing use for the treatment of depression and anxiety. Previous studies have indicated an increased risk of hyponatremia during the first months of treatment. We aimed to investigate the detailed time-course of SSRI-associated hyponatremia with a high temporal resolution, using registry data encompassing the total Swedish population. Read More

Clin Lung Cancer 2021 Mar 16. Epub 2021 Mar 16.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

Wellcome Open Res 2019 29;4:189. Epub 2021 Mar 29.

Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Hyponatremia is the commonest electrolyte abnormality in hospitalized patients and is associated with poor outcome. Hyponatremia is categorized on the basis of serum sodium into severe (< 120 mEq/L), moderate (120-129 mEq/L) and mild (130-134mEq/L) groups. Serum sodium has an important role in maintaining serum osmolality, which is maintained by the action of antidiuretic hormone (ADH) secreted from the posterior pituitary, and natriuretic peptides such as atrial natriuretic peptide and brain natriuretic peptide. Read More

Pediatrics 2021 May 1;147(5). Epub 2021 Apr 1.

Division of Pediatric Endocrinology and Metabolism, Mayo Clinic, Rochester, Minnesota

Arginine vasopressin (AVP)-mediated osmoregulatory disorders, such as diabetes insipidus (DI) and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) are common in the differential diagnosis for children with hypo- and hypernatremia and require timely recognition and treatment. DI is caused by a failure to concentrate urine secondary to impaired production of or response to AVP, resulting in hypernatremia. Newer methods of diagnosing DI include measuring copeptin levels; copeptin is AVP's chaperone protein and serves as a surrogate biomarker of AVP secretion. Read More

Horm Res Paediatr 2020 1;93(9-10):497-509. Epub 2021 Apr 1.

Division of Pediatric Endocrinology, Department of Pediatrics, School of Medicine, Marmara University, Istanbul, Turkey.

Background: Craniopharyngioma (CP), despite being a malformational tumor of low histological grade, causes considerable morbidity and mortality mostly due to hypothalamo-pituitary dysfunction that is created by tumor itself or its treatment.

Summary: Fluid-electrolyte disturbances which range from dehydration to fluid overload and from hypernatremia to hyponatremia are frequently encountered during the acute postoperative period and should be carefully managed to avoid permanent neurological sequelae. Hypopituitarism, increased cardiovascular risk, hypothalamic damage, hypothalamic obesity, visual and neurological deficits, and impaired bone health and cognitive function are the morbidities affecting the well-being of these patients in the long term. Read More

J Neurol Surg B Skull Base 2021 Apr 18;82(2):216-232. Epub 2019 Sep 18.

Hospital Santa Casa de Campo Grande, Universidade Federal de Mato Grosso do Sul, Campo Grande, Brazil.

 A novel technique is described for transpalatal hypophysectomy as an option for sellar region surgery using a microscope and/or endoscope.  A straight submucosal tunnel (approximately 20 mm in diameter; 40-50 mm long-half the length required by conventional transsphenoidal hypophysectomy) is dissected in favorable alignment with the main tumor axis, providing a direct view that allows the surgeon to operate on large suprasellar tumors, even in cases of extra-axial expansion.  In a 25-year period, over 50 patients benefited from this surgery. Read More

Case Rep Oncol 2021 Jan-Apr;14(1):134-140. Epub 2021 Mar 1.

Department of Surgery, National Hospital Organization Higashihiroshima Medical Center, Higashihiroshima, Japan.

Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a disease that leads to dilute hyponatremia through excessive secretion of antidiuretic hormone. SIADH has various causes, including ectopic ADH-producing tumors, drug properties, and can be idiopathic. But there have been very few reports of cases in which SIADH has developed after surgery for malignant tumors. Read More

Am J Case Rep 2021 Mar 24;22:e930135. Epub 2021 Mar 24.

Department of Nephrology, Brookdale University Hospital Medical Center, Brooklyn, NY, USA.

BACKGROUND During the coronavirus disease 2019 (COVID-19) pandemic of 2020, varied presentations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported. The present report is of a case of hyponatremia and encephalopathy due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) as the main presentation of SARS-CoV-2 infection in a 55-year-old woman. CASE REPORT A 55-year-old woman with type II diabetes mellitus presented with confusion and slurring of speech, with a temperature of 38. Read More

Med J Malaysia 2021 03;76(2):261-263

Hospital Teluk Intan, Department of Medicine, Perak, Malaysia.

A previously well 21-year-old girl presented to Hospital Teluk Intan, Perak, Malaysia with a short history of fever, vomiting and altered sensorium. She was diagnosed with dengue encephalitis as her dengue NS-1 antigen was positive and her cerebrospinal fluid (CSF) dengue polymerase chain reaction (PCR) was positive with serotype DENV-2. She also had severe hyponatremia due to Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) which caused an episode of seizure. Read More

BMJ Case Rep 2021 Mar 10;14(3). Epub 2021 Mar 10.

Department of Anaesthesia and Intensive Care, University College Cork, Cork, Ireland.

A previously healthy 48-year-old woman was referred to our intensive care unit (ICU) from a neurosurgical ward due to deterioration of her conscious level. She had a road traffic accident 6 days earlier. On admission to the hospital, a brain CT demonstrated subarachnoid haemorrhage which was considered not amenable to surgical intervention. Read More

J Family Med Prim Care 2020 Dec 31;9(12):6282-6284. Epub 2020 Dec 31.

Department of Pharmacy, Kuwana City Medical Center, Kuwana, Japan.

Duloxetine-induced hyponatraemia is a known adverse effect that can lead to potentially life-threatening complications. In addition, hypocortisolaemia is associated with the development of hyponatraemia. Here, we report a case of severe hyponatraemia rapidly presenting after duloxetine treatment in a patient with hypocortisolaemia. Read More

Cureus 2021 Feb 2;13(2):e13079. Epub 2021 Feb 2.

Internal Medicine, Serviço de Medicina 2, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, PRT.

Sweet taste dysgeusia is a rare symptom where patients experience all food as having a sweet taste. While its cause is still unknown, it has been increasingly reported in the setting of lung cancer and syndrome of inappropriate secretion of antidiuretic hormone-related hyponatremia. In this case report, we present what we believe to be the first case of sweet taste dysgeusia in a non-cancer context. Read More

Am J Case Rep 2021 Mar 4;22:e928055. Epub 2021 Mar 4.

Division of Community Medicine, Kanazawa Medical University Himi Municipal Hospital, Himi, Toyama, Japan.

BACKGROUND The etiology of syndrome of inappropriate antidiuretic hormone secretion (SIADH) is highly variable. With little evidence, much of the guidance and recommendations available for management are based on clinical judgement. Although percutaneous balloon kyphoplasty can effectively relieve the severe pain associated with osteoporotic vertebral compression fractures that do not respond to conventional treatments, the effect of balloon kyphoplasty on SIADH associated with vertebral compression fracture remains unknown. Read More

Z Gerontol Geriatr 2021 05 1;54(3):301-304. Epub 2021 Mar 1.

Vivantes Ida Wolff Hospital for Geriatric Medicine, Juchaczweg 21, 12351, Berlin, Germany.

Neurol India 2021 Jan-Feb;69(1):190-193

Department of Anaesthesia, AIIMS, Saket Nagar, Bhopal, Madhya Pradesh, India.

Hyponatremia in the neurocritical care patients is commonly encountered in the setting of either syndrome of inappropriate ADH secretion or cerebral salt wasting. However, differentiation of SIADH and CSW is paramount in view of their divergent treatment strategies. Read More

Eur J Endocrinol 2021 May;184(5):647-655

Intensive Care Unit, Department of Internal Medicine I, University Hospital of Wuerzburg, University of Wuerzburg, Wuerzburg, Germany.

Objective: Treatment of symptomatic hyponatremia is not well established. The European guidelines recommend bolus-wise administration of 150 mL of 3% hypertonic saline. This recommendation is, however, based on low level of evidence. Read More

Clin Nephrol Case Stud 2021 19;9:4-10. Epub 2021 Feb 19.

St. Elizabeth's Medical Center, Department of Medicine, Tufts University School of Medicine, and.

Cerebral salt wasting (CSW) is an uncommon cause of hyponatremia characterized by extracellular volume depletion, high urine sodium concentration and osmolality, and low serum uric acid concentration in association with central nervous system (CNS) disease. Distinguishing CSW from the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), a much more common form of hyponatremia in this setting, can be challenging because both present with identical laboratory features. However, treatment of CSW and SIADH differs, making a correct diagnosis important. Read More

Rev Med Suisse 2021 Feb;17(727):399-404

Service de néphrologie, Département de médecine, Réseau hospitalier neuchâtelois, 2000 Neuchâtel.

Along with the arrival of the first vasopressin-receptor V2R inhibitor, the indications for its use have increased. We review here and focus on polycystic kidney disease (PKD) and hyponatremia. Tolvaptan is the first drug available to slow down the progression of PKD in patients with rapid progressing disease. Read More

Med Clin (Engl Ed) 2021 Feb 16;156(4):195-196. Epub 2021 Feb 16.

Internal Medicine Department, Centre d'Atenció Integral Dos de Maig, Consorci Sanitari Integral, Barcelona, Spain.

J Int Med Res 2021 Feb;49(2):300060520985657

Department of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Small cell carcinoma of the cervix is a rare malignant tumor in the clinical setting. Clinical manifestations of this tumor are mostly similar to those of normal types of cervical cancer. Small cell carcinoma of the cervix only shows symptoms of neuroendocrine tumors, such as syndrome of inappropriate antidiuretic hormone secretion (SIADH). Read More

Am J Case Rep 2021 Feb 16;22:e929050. Epub 2021 Feb 16.

Department of Hospital Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

BACKGROUND Syphilis has increased in prevalence in the United States by 72.7% from 2013 to 2017, with the highest rates recorded in men who have sex with men. There is an increased incidence of syphilis in patients with a concomitant HIV infection, estimated at a 77-fold increase. Read More

J Clin Neurosci 2021 Mar 15;85:72-77. Epub 2021 Jan 15.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Neurosurgery, Department of Surgery, National University Hospital, National University Health System, Singapore.

Little evidence exists to guide the preoperative selection of elderly brain tumor patients who are fit for surgery. We aimed to evaluate the safety of brain tumor resection in geriatric patients and identify predictors of postoperative 30-day systemic complications. We conducted a retrospective cohort study of 212 consecutive patients at or above the age of 60 years who underwent elective brain tumor resection between 2007 and 2017. Read More

BMJ Case Rep 2021 Feb 9;14(2). Epub 2021 Feb 9.

Department of Endocrinology, Diabetes and Metabolism, William Beaumont Hospital, Royal Oak, Michigan, USA.

Pituitary apoplexy (PA) is an endocrine emergency presenting with headache, visual and hormonal disturbances. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is rare after PA. A 64-year-old woman presented with acute frontal headache and nausea with normal neurological examination. Read More

J Cell Physiol 2021 Feb 8. Epub 2021 Feb 8.

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Aquaporins (AQPs), as transmembrane proteins, were primarily identified as water channels with the ability of regulating the transmission of water, glycerol, urea, and other small-sized molecules. The classic view of AQPs involvement in therapeutic plan restricted them and their regulators into managing only a narrow spectrum of the diseases such as diabetes insipidus and the syndrome of inappropriate ADH secretion. However, further investigations performed, especially in the third millennium, has found that their cooperation in water transmission control can be manipulated to handle other burden-imposing diseases such as cirrhosis, heart failure, Meniere's disease, cancer, bullous pemphigoid, eczema, and Sjögren's syndrome. Read More

Ann Transl Med 2021 Jan;9(1):28

Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Hyponatremia induced by syndrome of inappropriate antidiuretic hormone secretion (SIADH) was common electrolyte disturbance encountered in critically ill neurological diseases, which has normal or increased fluid volume. Brain natriuretic peptide (BNP), which is released in equal proportion to N-terminal pro-brain natriuretic peptide (NT-proBNP), plays vital roles in regulation of volume status. The relationship between SIADH and NT-proBNP levels in neurological diseases has rarely been reported. Read More