Circ Arrhythm Electrophysiol 2017 Dec;10(12)
From the Nora Eccles Harrison Cardiovascular Research and Training Institute (N.P., R.R., D.J.D.), Division of Cardiothoracic Surgery, Department of Surgery (D.J.D.), and Division of Cardiovascular Medicine, Department of Medicine (L.L., R.R., D.J.D.), University of Utah, Salt Lake City; and Division of Cardiovascular Disease, School of Medicine, University of Alabama at Birmingham (J.H., R.E.I.).
Background: Understanding the mechanisms that drive ventricular fibrillation is essential for developing improved defibrillation techniques to terminate ventricular fibrillation (VF). Distinct organization patterns of chaotic, regular, and synchronized activity were previously demonstrated in VF that persisted over 1 to 2 minutes (long-duration VF [LDVF]). We hypothesized that activity on the endocardium may be driving these activation patterns in LDVF and that unsuccessful defibrillation shocks may alter activation patterns. Read More