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Dysphagia 2019 Feb 14. Epub 2019 Feb 14.

Division of Phoniatrics-Logopedics, Department of Otorhinolaryngology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

To compare the results of a simultaneously performed videofluoroscopic swallowing study and fiberendoscopic evaluation of swallowing in patients with dysphagia after surgery and radiotherapy for oropharyngeal or laryngeal cancer. This prospective study included 31 patients who were examined simultaneously with a standardized protocol. The fiberendoscopic and videofluoroscopic swallowing loops were independently scored by two otorhinolaryngologists/phoniatricians and two radiologists. Read More

Laryngoscope 2019 Feb 13. Epub 2019 Feb 13.

Department of Speech, Language, and Swallowing Disorders, Massachusetts General Hospital, Boston, Massachusetts, U.S.A.

Int J Eat Disord 2019 Feb 13. Epub 2019 Feb 13.

Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts.

Objective: Since its introduction to the psychiatric nomenclature in 2013, research on avoidant/restrictive food intake disorder (ARFID) has proliferated highlighting lack of clarity in how ARFID is defined.

Method: In September 2018, a small multi-disciplinary pool of international experts in feeding disorder and eating disorder clinical practice and research convened as the Radcliffe ARFID workgroup to consider operationalization of DSM-5 ARFID diagnostic criteria to guide research in this disorder.

Results: By consensus of the Radcliffe ARFID workgroup, ARFID eating is characterized by food avoidance and/or restriction, involving limited volume and/or variety associated with one or more of the following: weight loss or faltering growth (e. Read More

Codas 2019 Feb 11;31(1):e20180083. Epub 2019 Feb 11.

Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre (RS), Brasil.

Purpose: To describe the presence of speech-language therapists (SLT) in the primary health care (PHC) in Brazil and its association with socioeconomic inequalities.

Methods: Cross-sectional study with 17,157 PHC services in all Brazilian states. Based on the NASF External Assessment Questionnaire sub-item "speech-language therapist", which was used to answer the question "What NASF professionals support your PHC service?", in addition to contextual data (regional population, number of registered SLP, speech therapy college courses, city HDI and Gini Index). Read More

Int J Med Sci 2019 1;16(2):253-263. Epub 2019 Jan 1.

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, "Aldo Moro" University of Bari, Italy.

Temporomandibular disorders (TMD) represent a heterogeneous group of inflammatory or degenerative diseases of the stomatognatic system, with algic and/or dysfunctional clinical features involving temporomandibular joint (TMJ) and related masticatory muscles. Rheumatoid Arthritis (RA) is an autoimmune polyarthritis characterized by the chronic inflammation of synovial joints and oral implications such as hyposalivation, difficulty in swallowing and phoning, feeling of burning mouth, increased thirst, loss of taste or unpleasant taste and smell, dental sensitivity. The aim of this observational study was to investigate the prevalence of TMD symptoms and signs as well as oral implications in patients with Early Rheumatoid Arthritis (ERA), that is a RA diagnosed within 12 months, compared with a control group. Read More

FASEB J 2019 Feb 11:fj201801385RR. Epub 2019 Feb 11.

Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany.

The glucocorticoid receptor (GR) represents the crucial molecular mediator of key endocrine, glucocorticoid hormone-dependent regulatory circuits, including control of glucose, protein, and lipid homeostasis. Consequently, aberrant glucocorticoid signaling is linked to severe metabolic disorders, including insulin resistance, obesity, and hyperglycemia, all of which also appear upon chronic glucocorticoid therapy for the treatment of inflammatory conditions. Of note, long-term glucocorticoid exposure under these therapeutic conditions typically induces glucocorticoid resistance, requiring higher doses and consequently triggering more severe metabolic phenotypes. Read More

Arch Phys Med Rehabil 2019 Feb 5. Epub 2019 Feb 5.

Swallowing Research Laboratory, University of Central Florida.

Objective: To expand the scope of prior spontaneous swallowing frequency analysis (SFA) studies, by evaluating the role of SFA in dysphagia-and stroke-related outcomes at acute stroke discharge.

Design: Period prevalence study SETTING: Tertiary care university hospital PARTICIPANTS: 96 patients with acute stroke.

Interventions: Subjects were screened for dysphagia using SFA. Read More

Curr Treat Options Gastroenterol 2019 Feb 8. Epub 2019 Feb 8.

Esophageal and Swallowing Center, Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.

ᅟRefractory GERD is very common, and while many different underlying mechanisms have been identified, the main focus has remained on residual reflux (acidic or non-acidic). Recently, Rome IV introduced two new concepts with important impact on patients with refractory GERD. They include the introduction of the reflux hypersensitivity group and the proposal that GERD can overlap with a functional esophageal disorder. Read More

Dig Surg 2019 Feb 5:1-9. Epub 2019 Feb 5.

Division of General Surgery, Morsani College of Medicine, University of South Florida, Tampa, Florida,

Purpose: The purpose of this study was to compare demographics, symptoms, prior interventions, operation, and outcomes of patients who underwent Heller myotomy for esophageal motility disorders and epiphrenic diverticulectomy with Heller myotomy.

Methods: We identified all patients who underwent Heller myotomy for esophageal motility disorders with and without esophageal diverticulectomy over an 80-month period. Primary data points included patient demographics, presenting symptoms, prior intervention, high-resolution manometry, surgery performed with rate of laparoscopic, conversion to open, and open procedures; postoperative complications, and symptom resolution. Read More

Vestn Otorinolaringol 2018 ;83(6):13-17

Z.P. Solov'ev Research and Practical Psycho-Neurological Centre, Moscow Health Department, Moscow, Russia, 115419.

The present study was designed to carry out the comprehensive clinical examination of 120 patients presenting with paresthesia of the upper respiratory tract (42 men (35%) and 78 women (65%P) aged 56 to 90 years). The most frequent complaints included cough (72%), globus sensation (46%), itching (43%), dry throat (38%), and difficulty of swallowing (28%). The duration of the clinical symptoms ranged from 1 month to 3 years (m±M: 1+to 1. Read More

Dysphagia 2019 Feb 2. Epub 2019 Feb 2.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Monroe Carell Jr. Children's Hospital at Vanderbilt University Medical Center, Doctors Office Tower, Suite 10226, 2200, Children's Way, Nashville, TN, 37232, USA.

Eosinophilic esophagitis (EoE) can affect eating behavior in infants and children and this may lead to stressful interactions with their caregivers and potentially impact their caregivers' quality of life. Clinical evaluation of eating behaviors can be time consuming and burdensome. Caregivers can provide a comprehensive assessment of their child's eating behavior; however, this has not been well studied in children with EoE. Read More

Neuroimage Clin 2019 Jan 22;22:101685. Epub 2019 Jan 22.

Department of Health Sciences and Research, College of Health Professions, Medical University of South Carolina, 77 President St, MSC 700, Charleston, SC 29425, USA; Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, 135 Rutledge Ave, MSC 550, Charleston, SC 29425, USA.

Dysphagia is a common deficit after a stroke, and it is frequently associated with pneumonia, malnutrition, dehydration, and poor quality of life. It is not yet fully clear which brain regions are directly related to swallowing, and how lesions affect swallow physiology. This study aimed to assess the statistical relationship between acute stroke lesion locations and impairment of specific aspects of swallow physiology. Read More

Int J Pediatr Otorhinolaryngol 2019 Jan 26;119:141-146. Epub 2019 Jan 26.

Ghent University, Department of Speech, Language, and Hearing Sciences, Ghent, Belgium; University of Pretoria, Faculty of Humanities, Department of Speech-Language Pathology and Audiology, Pretoria, South Africa.

Objectives: Recently, the Velopharyngeal Insufficiency (VPI) Effects on Life Outcomes (VELO) questionnaire, which evaluates the impact of speech and swallowing difficulties on health-related quality of life (HRQoL) in patients with VPI (Skirko et al., 2012), was translated to Dutch (Bruneel et al., 2017). Read More

Dysphagia 2019 Feb 1. Epub 2019 Feb 1.

Institut de Recherche Expérimentale et Clinique (IREC), Pôle de Pneumologie, ORL & Dermatologie, Université Catholique de Louvain, Brussels, Belgium.

Oropharyngeal dysphagia is frequently under-reported and early detection may lead to adapt strategies of rehabilitation and management decisions. The Sydney Swallow Questionnaire (SSQ), a self-reported questionnaire for the detection and quantification of oropharyngeal dysphagia, was previously adapted and validated in other languages but not in French. The purposes of this study were to develop and validate a French version of SSQ (SSQ-f) and to assess its psychometric properties. Read More

Ter Arkh 2018 Nov;90(11):102-104

Bashkir State Medical University, Ufa, Bashkortostan, Russia.

Injections of botulinum toxin are widely used in different medical fields, namely neurology, urology, stomatology, cosmetology, gastroenterology etc. Preparations of botulinum toxin type A (BTA) prevent the release of acetylcholine at the endings of motor nerves leading to the long-term muscle relaxation. It has been acknowledged that treatment with BTA has very good safety profile and tolerability. Read More

Expert Rev Clin Pharmacol 2019 Jan 31:1-16. Epub 2019 Jan 31.

b Mental Health Research Center at Eastern State Hospital , University of Kentucky , Lexington , KY , USA.

Introduction: This is a comprehensive review of antipsychotic (AP)-induced dysphagia and its complications: choking and pneumonia. Areas covered: Four PubMed searches were completed in 2018. The limited literature includes: 1) 45 case reports of AP-induced dysphagia with pharmacological mechanisms, 2) a systematic review of APs as a risk factor for dysphagia, 3) reviews suggesting adult patients with intellectual disability (ID) and dementia are prone to dysphagia (APs are a risk factor among multiple others), 4) studies of the increased risk of choking in patients with mental illness (APs are a contributing factor), 5) naturalistic pneumonia studies suggesting that pneumonia may contribute to AP-increased death in dementia, and 6) naturalistic studies suggesting that pneumonia may be a major cause of morbidity and mortality in clozapine patients. Read More

Head Neck 2019 Jan 30. Epub 2019 Jan 30.

Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.

Background: A reliable method of measuring functional outcomes is essential to inform treatment decisions in head and neck cancer.

Methods: Members of the American Head and Neck Society were surveyed regarding their use of functional outcome assessment tools. Qualitative statistical analysis was performed to identify major tools used and to clarify obstacles to functional outcome assessment. Read More

Dysphagia 2019 Jan 29. Epub 2019 Jan 29.

Department of Otolaryngology, Head and Neck Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML #0528, Cincinnati, OH, 45267-0528, USA.

While voice-related disorders in Parkinson's disease (PD) are commonly discussed in the literature, dysphagia in PD is less widely published. Vocal fold augmentation, including injection laryngoplasty (IL), is a well-established treatment for glottal insufficiency (Cates et al. in Otolaryngol Head Neck Surg 155(3):454-457, 2016). Read More

Dysphagia 2019 Jan 29. Epub 2019 Jan 29.

Department of Otolaryngology, Boston University School of Medicine, Boston, MA, USA.

Dysphagia is common in hospitalized patients post-extubation and associated with poor outcomes. Laryngeal sensation is critical for airway protection and safe swallowing. However, current understanding of the relationship between laryngeal sensation and aspiration in post-extubation populations is limited. Read More

Disabil Rehabil 2019 Jan 29:1-10. Epub 2019 Jan 29.

b Speech Pathology, Faculty of Health Sciences , The University of Sydney , Australia.

Purpose: Oropharyngeal dysphagia and laryngeal dysfunction are known to impact on health outcomes of patients with critical illness. The incidence in patients after heart and/or lung transplantation is unknown. This paper investigates the frequency, characteristics and risk factors for these complications following such transplantation. Read More

Burns 2019 Jan 25. Epub 2019 Jan 25.

Department of Speech, Language and Hearing Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.

Introduction: Major burn patients are exposed to different invasive procedures for wound management or medical stabilization. Dysphagia is a frequent adverse effect of burns in the presence of invasive airway procedures and facial wounds.

Objective: To estimate the prevalence of dysphagia, to determine the degree of severity, and to report clinical characteristics that could contribute to the appearance of dysphagia in patients admitted to a National Burn Reference Centre. Read More

J Bodyw Mov Ther 2019 Jan 31;23(1):171-176. Epub 2018 Jan 31.

Department of Speech Therapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Dysphagia is common following Multiple Sclerosis (MS) and is associated with significant morbidity and mortality. The current rehabilitation program to swallowing therapy is Traditional Dysphagia Therapy (TDT), but there is a dearth of evidence about its effectiveness in MS patients.

Objectives: This study was aimed to determine the effects of the TDT on the swallowing function in MS patients with dysphagia. Read More

Front Appl Math Stat 2018 Jul 2;4. Epub 2018 Jul 2.

Department of Surgery, Division of Otolaryngology-Head & Neck Surgery, University of Wisconsin - Madison, Madison, WI, USA.

Any movement performed repeatedly will be executed with inter-trial variability. Oropharyngeal swallowing is a complex sensorimotor action, and swallow-to-swallow variability can have consequences that impact swallowing safety. Our aim was to determine an appropriate method to measure swallowing pressure waveform variability. Read More

Curr Treat Options Gastroenterol 2019 Jan 25. Epub 2019 Jan 25.

Division of Gastroenterology, Hepatology, and Nutrition, Center for Swallowing and Esophageal Disorders, Digestive Disease Center, Vanderbilt University Medical Center, 1660 TVC, Nashville, TN, 37232-5280, USA.

Purpose Of Review: Gastroesophageal reflux disease (GERD) is a common diagnosis encountered by both primary care providers and specialists, but despite its prevalence, there are limitations in the current diagnostic tests for GERD. Once an accurate diagnosis is made, treatment options can be offered, and this field continues to burgeon with options. In this review, we seek to review the recent advances in GERD diagnostics and subsequent treatment options. Read More

Dysphagia 2019 Jan 25. Epub 2019 Jan 25.

Department of Intensive Care Medicine, Inselspital, University Hospital of Bern, University of Bern, Freiburgstrasse 18, 3010, Bern, Switzerland.

Swallowing disorders and respective consequences (including aspiration-induced pneumonia) are often observed in extubated ICU patients with data indicating that a large number of patients are affected. We recently demonstrated in a large-scale analysis that the incidence of post-extubation dysphagia (PED) is 12.4% in a general ICU population and about 18% in emergency admissions to the ICU. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14241

Background: Melatonin generated in the gastrointestinal tract has mucosal protective effect with inhibiting gastric acid secretion, while increasing gastrin release, which in turn stimulates the contractility of lower esophageal sphincter. Gastroesophageal reflux disease (GERD) is also known to have association with sleep disturbance. However, melatonin or melatonin receptor agonist has not been included in the treatment of GERD. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14173

Department of Proctology, Jining No.1 People's Hospital, Jining, Shandong, China.

Background: Gastroesophageal reflux disease (GERD) is one of the most common digestive system diseases, which is associated with lifestyle and dietary factors. The main mechanism involved in GERD is affected by demographics, lifestyles, and dietary factors. Tea consumption is reported to be associated with GERD, especially in Asian population. Read More

Food Sci Nutr 2019 Jan 5;7(1):96-108. Epub 2018 Nov 5.

Department of Clinical Nutrition and Dietetics Faculty of Nutrition Sciences and Food Technology National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran.

Ginger, the rhizome of Zingiber officinale, which is used as a spice globally has a long history of medicinal use that stimulates investigators to assess its potential roles as an adjuvant therapy or alternative medicine in a range of diseases. Anti-inflammatory, antioxidant, antitumor, and antiulcer effects of ginger have been proven in many scientific studies, and some of the ancient applications of ginger as a home remedy has been confirmed in human. In this review, we summarized the current evidence on the effects of ginger consumption on gastrointestinal disorders based on clinical trials. Read More

J Laryngol Otol 2018 Dec;132(12):1128-1133

Department of Otolaryngology, Head and Neck Surgery,Faculty of Medicine,Tottori University,Yonago,Japan.

Background: In endoscopic cricopharyngeal myotomy, surgeons sometimes have concerns about performing an adequate incision with only a narrow intra-cavital view from one direction. In order to overcome these issues, fluoroscopic radiography was used during endoscopic cricopharyngeal myotomy.

Methods: Peri-operative fluoroscopic radiography was utilised to check the position of the diverticuloscope, and to confirm the extent of the incision during surgery. Read More

BMC Gastroenterol 2019 Jan 23;19(1):15. Epub 2019 Jan 23.

Department of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, People's Republic of China.

Background: Superior mesenteric artery (SMA) syndrome, also known as Wilkie's syndrome or Benign duodenal stasis, is a rare benign disease. It could threaten the life if the manifestation is severe and the treatment is inappropriate. In the patients with SMA syndrome, the third portion (transverse part) of the duodenum is compressed externally between the SMA and abdominal aorta (AA) leading to duodenal stasis and gastrointestinal obstruction. Read More

Dysphagia 2019 Jan 23. Epub 2019 Jan 23.

Diagnostic Centre of Imaging and Functional Medicine, Skåne University Hospital, Lund University, Malmö, Sweden.

The pharynx is critical for correct swallowing, facilitating the transport of both air and food transport in a highly coordinated manner, and aberrant co-ordination causes swallowing disorders (dysphagia). In this work, an in vitro model of swallowing was designed to investigate the role of rheology in swallowing and for use as a pre-clinical tool for simulation of different routes to dysphagia. The model is based on the geometry of the human pharynx. Read More

PLoS One 2019 23;14(1):e0211040. Epub 2019 Jan 23.

The Nippon Dental University, Tama Oral Rehabilitation Clinic, Tokyo, Japan.

Objective: This study was carried out to determine the prevalence of suspected dysphagia and its features in both independent and dependent older people living at home.

Materials And Methods: The 10-Item Eating Assessment Tool (EAT-10) questionnaire was sent to 1,000 independent older people and 2,000 dependent older people living at home in a municipal district of Tokyo, Japan. The participants were selected by stratified randomization according to age and care level. Read More

Aging Clin Exp Res 2019 Jan 22. Epub 2019 Jan 22.

Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milan, Italy.

Aging is accompanied by several changes which may affect swallowing function. The beginning of these changes, termed presbyphagia, still captures a preserved swallowing function, although burdened by the consequences of the physiological aging process. Several stressors (including diseases and medications) can easily trigger the disruption of this (increasingly weak) equilibrium and lead to overt dysphagia. Read More

J Tissue Eng Regen Med 2019 Jan 21. Epub 2019 Jan 21.

Nano3D Biosciences Inc, University of Texas Health Sciences Center at Houston, Houston, Texas, USA, Houston, Texas, USA.

Salivary gland (SG) hypofunction and oral dryness can be induced by radiotherapy for head and neck cancers or auto-immune disorders. These are common clinical conditions that involve loss of saliva-secreting epithelial cells. Several oral complications arise with SG hypofunction that interfere with routine daily activities like chewing, swallowing and speaking. Read More

Gastrointest Endosc 2019 02;89(2):274-276

Predictive Health, University of Arizona College of Medicine - Phoenix, Phoenix, Arizona, USA.

Gut Liver 2019 01;13(1):3-4

Department of Internal Medicine, Pusan National University School of Medicine, and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Int J Lang Commun Disord 2019 Jan 21. Epub 2019 Jan 21.

Department of Communication Disorders, The University of Canterbury, Christchurch, New Zealand.

Background: The Test of Masticating and Swallowing Solids (TOMASS) has been developed to provide clinicians with objective data regarding the efficiency of oral phase function and solid bolus ingestion.

Aims: To determine if the TOMASS will detect changes in the oral phase of swallowing imposed by topical anaesthesia, thus providing validation of its clinical utility.

Methods & Procedures: Per the standard protocol, 10 healthy participants ate one-quarter of an Arnotts Salada biscuit. Read More

Tohoku J Exp Med 2019 ;247(1):41-49

Division of Gastroenterology and Hepatobiliary Pancreatic Surgery, Tohoku Medical and Pharmaceutical University.

Esophageal achalasia is a disease characterized by the impaired esophageal peristalsis and non-relaxation of the lower esophageal sphincter muscle with unknown causes. Clinical manifestation of the disease is nonspecific (e.g. Read More

Pol J Radiol 2018 13;83:e394-e400. Epub 2018 Aug 13.

Section of Radiological Sciences, DIBMIMEF, University Hospital Policlinico, University of Palermo, Palermo, Italy.

Patients with neurologic diseases almost inevitably develop various degrees of swallowing disorders during their life. Dysphagia is one of the main negative prognostic factors in this class of patients, leading to severe morbidity (i.e. Read More

Medicine (Baltimore) 2019 Jan;98(3):e13910

This study aims to analyze the etiology of nonspecific chronic cough in children of 5 years and younger, in order to improve the diagnostic and treatment levels of pediatricians for nonspecific chronic cough in young children.The clinical data of 85 cases of children of 5 years old and below, who suffered from nonspecific chronic cough between the period of January 2015 and August 2016 were retrospectively analyzed.The etiology distribution of 85 cases of children with nonspecific chronic cough were as follows: 27 cases had cough variant asthma (31. Read More

Laryngoscope 2019 Jan 15. Epub 2019 Jan 15.

Department of Otolaryngology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, U.S.A.

Objective: With the intensification and utilization of multimodal treatment, acute toxicities have increased; however, the frequency of treatment sequelae in long-term head and neck cancer (HNC) survivors are poorly described. The purpose of this analysis was to determine the prevalence and predictors of patient-reported late and long-term treatment-related sequelae in HNC survivors.

Methods: We performed a cross-sectional analysis of patient-reported outcomes from 228 survivors attending a multidisciplinary HNC survivorship clinic. Read More

Int Arch Otorhinolaryngol 2019 Jan 25;23(1):25-30. Epub 2018 Jul 25.

Faculty of Medicine, Universidade São Francisco, Bragança Paulista, SP, Brazil.

 Feeding, swallowing and breathing are fundamental activities for the survival and well-being of humans; these functions are performed by the most complex neuromuscular unit of the human body, which, when altered, may raise morbidity and mortality rates.  To evaluate deglutition in patients with mental disability in order to determine the incidence and the severity of dysphagia.  A total of 189 institutionalized adult patients with mental disability were analyzed using a 3. Read More

Int Arch Otorhinolaryngol 2019 Jan 11;23(1):7-11. Epub 2018 Oct 11.

Department of ENT, Lancaster Royal Infirmary, Lancaster, United Kingdom of Great Britain and Northern Ireland.

 Transnasal esophagoscopy (TNE) is a widely used tool both in the diagnosis and treatment of patients presenting complaints within the head and the neck. This is because this investigative adjunct examination provides the advantage of visualizing above the level of the cricopharyngeus muscle when compared to the more widely used esophagogastroduodenoscopy (EGD).  We have assessed if the implementation of TNE within a district general hospital (DGH) was feasible, and investigated if the resources of our patients could be better directed away from other investigations such as barium swallow and EGD in favor of this novel technique. Read More

Tohoku J Exp Med 2019 01;247(1):19-25

Department of Otorhinolaryngology, Nagoya City University.

Patients with laryngopharyngeal reflux (LPR) were reported to suffer from hypogeusia that affects quality of life. Proton pump inhibitor (PPI) is a useful drug in the treatment of LPR, but its effect on hypogeusia is not known. We therefore assessed the effects of PPI or a histamine H2 receptor antagonist (H2 blocker) on hypogeusia among patients with LPR. Read More

Dysphagia 2019 Jan 14. Epub 2019 Jan 14.

Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

Pharyngeal residue, the material that remains in the pharynx after swallowing, is an important marker of impairments in swallowing and prandial aspiration risk. The goals of this study were to determine whether the 2D area of post-swallow residue accurately represents its 3D volume, and if the laterality of residue would affect this association. Thirteen patients with dysphagia due to brainstem stroke completed dynamic 320-detector row computed tomography while swallowing a trial of 10 ml honey-thick barium. Read More

Dysphagia 2019 Feb 11;34(1):34-42. Epub 2019 Jan 11.

Center for Swallowing Disorders, University of South Florida, 13330 USF Laurel Drive, Tampa, FL, 33612, USA.

The modified  barium swallow (MBS) study is a videofluoroscopic evaluation of oropharyngeal swallow function. Esophageal imaging is not routinely performed during an MBS, and few guidelines for implementation or interpretation exist. Aims of the current investigation were to (1) delineate the percentage of normal, oropharyngeal, esophageal, and mixed swallowing dysfunction, (2) develop operational definitions for rating our standardization cursory view of esophageal bolus flow, and (3) determine inter-rater reliability between speech pathology (SLP) and physician raters for categorizing esophageal abnormalities. Read More

Exp Gerontol 2019 Jan 8;118:45-50. Epub 2019 Jan 8.

Division of Otolaryngology-Head and Neck Cancer, Department of Surgery, University of Wisconsin School of Medicine and Public Health, United States of America; Department of Biomedical Engineering, University of Wisconsin-Madison, United States of America; Department of Communication Sciences and Disorders, University of Wisconsin-Madison, United States of America.

Background: Aging rodent models allow for the discovery of underlying mechanisms of cranial muscle dysfunction. Methods are needed to allow quantification of complex, multivariate biomechanical movements during swallowing. Videofluoroscopic swallow studies (VSS) are the standard of care in assessment of swallowing disorders in patients and validated quantitative, kinematic, and morphometric analysis methods have been developed. Read More

Head Neck 2019 Jan 10. Epub 2019 Jan 10.

Statistician - Holden Comprehensive Cancer Center, University of Iowa.

Background: Swallowing dysfunction after radiotherapy (RT) for head and neck cancer can be devastating. A randomized control trial compared swallow exercises versus exercise plus neuromuscular electrical stimulation therapy and found no overall difference in outcomes.

Methods: Quality of life (QOL), diet, and swallowing variables collected at discrete intervals on 117 patients were reanalyzed to test the hypothesis that shorter time between the completion of radiotherapy and beginning of the swallowing therapy program yielded improved outcomes. Read More

J Pediatr Gastroenterol Nutr 2019 Jan 4. Epub 2019 Jan 4.

Department of Gastroenterology, North Hospital, Assistance Publique - Hôpitaux de Marseille, Marseille, France.

Objectives: High-resolution manometry (HRM) is the gold standard for diagnosis of esophageal motility disorders. However, clinical signs associated with these disorders are non-specific, and it is difficult to correlate clinical signs with HRM data. The main objective of our study was to assess the positive predictive value (PPV) and negative predictive value (NPV) of each clinical sign, as well as their sensitivity and specificity in the diagnosis of esophageal motility disorders. Read More