3,270 results match your criteria Surgical Treatment of Vulvar Cancer


The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD) and the European Federation for Colposcopy (EFC) Consensus Statements on Pre-invasive Vulvar Lesions.

J Low Genit Tract Dis 2022 Jul 21;26(3):229-244. Epub 2022 Jun 21.

Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Abstract: The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) developed consensus statements on pre-invasive vulvar lesions in order to improve the quality of care for patients with vulvar squamous intraepithelial neoplasia, vulvar Paget disease in situ, and melanoma in situ. For differentiated vulvar intraepithelial neoplasia (dVIN), an excisional procedure must always be adopted. For vulvar high-grade squamous intraepithelial lesion (VHSIL), both excisional procedures and ablative ones can be used. Read More

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SIIV position paper: clinical approach to vulval diseases: need for quality standards.

Minerva Obstet Gynecol 2022 Jun 22. Epub 2022 Jun 22.

Section of Dermatology and Infectious Diseases, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

This paper summarizes the position of the Italian Society of Vulvology (SIIV) on the clinical approach to vulval disease. A thorough history (general medical, gynaecological, and vulval history) is essential for a successful and fruitful vulvological examination. Characteristics of pruritus (itch) and pain, that are the two main vulval symptoms, should be collected and reported with precision, according to duration, temporal course, location, provocation, and intensity. Read More

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The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD) and the European Federation for Colposcopy (EFC) consensus statements on pre-invasive vulvar lesions.

Int J Gynecol Cancer 2022 Jun 21. Epub 2022 Jun 21.

Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) developed consensus statements on pre-invasive vulvar lesions in order to improve the quality of care for patients with vulvar squamous intraepithelial neoplasia, vulvar Paget disease in situ, and melanoma in situ. For differentiated vulvar intraepithelial neoplasia (dVIN), an excisional procedure must always be adopted. For vulvar high-grade squamous intraepithelial lesion (VHSIL), both excisional procedures and ablative ones can be used. Read More

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Diagnosis and management of primary vulvar adenocarcinoma of mammary gland type: report of two distinct cases.

BMJ Case Rep 2022 Jun 7;15(6). Epub 2022 Jun 7.

Gynecology, Instituto Portugues de Oncologia do Porto Francisco Gentil EPE, Porto, Portugal.

Adenocarcinoma of mammary gland type (AMGT) of the vulva is extremely rare and its aetiopathogenesis is not fully understood. Low incidence is partly responsible for the lack of guidelines for patient management. Here, two cases of postmenopausal patients diagnosed with AMGT with different therapeutical approaches are reported. Read More

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[Clinical analysis of 23 cases with simultaneous double primary gynecological malignant tumors].

Zhonghua Fu Chan Ke Za Zhi 2022 May;57(5):352-360

Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100006, China.

To investigate the clinicopathological features, diagnosis, treatment and prognosis of simultaneous double primary gynecological malignant tumors. A total of 23 patients with simultaneous double primary malignant tumors of female reproductive system primarily treated in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from January 1, 2010 to December 31, 2020 were retrospectively collected. The age, symptoms, tumor stage, tumor type, treatment and prognosis of patients were collected and followed up. Read More

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Trans-inguinal pelvic lymphadenectomy in vulvar cancer patients: TRIPLE pilot study.

Int J Gynecol Cancer 2022 May 26. Epub 2022 May 26.

Dipartimento Universitario Scienze della Vita e Sanità Pubblica - Sezione di Ginecologia ed Ostetricia - Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: The goal of this study was to assess the feasibility and safety of a retrograde extraperitoneal trans-inguinal novel approach to pelvic lymphadenectomy in vulvar cancer patients. The secondary objectives were to assess complications (early and late) and oncological outcomes.

Methods: In this pilot study, all patients referred to our institution from November 2019 to May 2021 were evaluated. Read More

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Declining use of inguinofemoral lymphadenectomy in the treatment of clinically negative, pathologic node positive vulvar cancer.

Gynecol Oncol 2022 Jul 9;166(1):61-68. Epub 2022 May 9.

Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, United States of America.

Purpose: The management of vulvar cancer with clinically negative groin lymph nodes but with positive sentinel lymph node biopsy (SLNB) is controversial, with options including inguinofemoral lymphadenectomy (IFL) and/or adjuvant chemotherapy and radiotherapy. We used the National Cancer Database (NCDB) to examine trends in the management of clinically node negative, pathologically node positive (cN-/pN+) patients.

Methods: The NCDB was used to identify cN-/pN+ vulvar cancer patients. Read More

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The impact of distance to closest negative margin on survival after pelvic exenteration.

Gynecol Oncol 2022 Jun 26;165(3):514-521. Epub 2022 Apr 26.

H. Lee Moffitt Cancer Center, Department of Gynecologic Oncology, United States of America. Electronic address:

Objective: To determine the effect of distance to closest negative margin on survival after pelvic exenteration (PE).

Methods: In this retrospective analysis of PE at Moffitt Cancer Center from 2000 to 2019, baseline characteristics, clinical details, and outcomes were ascertained. Distance to closest negative margin was measured. Read More

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Preoperative predictors of inguinal lymph node metastases in vulvar cancer - A nationwide study.

Gynecol Oncol 2022 Jun 26;165(3):420-427. Epub 2022 Apr 26.

Department of Gynaecology, Copenhagen University Hospital, Rigshospitalet, Denmark.

Background: A combination of tumour size, differentiation grade and location may identify a group of vulvar squamous cell cancer (VSCC) patients with a very low risk of inguinal lymph node metastasis. We aim to examine these findings in a large national cohort of VSCC patients.

Materials And Methods: Population based prospective data on VSCC patients treated with vulvectomy and primary groin surgery was obtained from the Danish Gynaecological Cancer Database. Read More

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Topical imiquimod versus surgery for vulvar intraepithelial neoplasia: a multicentre, randomised, phase 3, non-inferiority trial.

Lancet 2022 05 25;399(10337):1790-1798. Epub 2022 Apr 25.

Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria.

Background: The optimal management of vulvar high-grade squamous intraepithelial lesions (vHSILs) is challenging. Surgery is the standard treatment, but recurrences are observed in half of patients. Medical treatment with imiquimod is an effective alternative, but the two modalities have not been compared in a randomised trial. Read More

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Single centre experience of 800 gynaecologic oncology cases in 2020: influence of pandemy on cancer surgeries.

J Obstet Gynaecol 2022 Apr 27:1-5. Epub 2022 Apr 27.

Department of Gynecologic Oncology, University of Health Sciences Turkey, Zeynep Kamil Training and Research Hospital, Istanbul, Turkey.

We aimed to evaluate the gynaecological oncology surgeries in the COVID-19 pandemic. A total of 800 operations performed between January and December 2020 were retrieved. Since the COVID-19 pandemic affected operations as of April 1 2020, we compared the cases of the last nine months of the year with the first three months. Read More

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Sentinel lymph node procedure in patients with recurrent vulvar squamous cell carcinoma: a proposed protocol for a multicentre observational study.

BMC Cancer 2022 Apr 23;22(1):445. Epub 2022 Apr 23.

Department of Gynaecologic Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, P.O. Box 2040, 3000, CA, Rotterdam, The Netherlands.

Background: Standard groin treatment in recurrent vulvar cancer consists of uni- or bilateral inguinofemoral lymphadenectomy (IFL), whereas in the primary setting women with selected unifocal tumours will undergo a sentinel lymph node (SLN) procedure. The SLN procedure results in fewer short and long-term sequelae compared to IFL, but some concerns must first be considered. Lymph drainage of the vulvar region can be affected by a previous surgery, which might reduce the number of detectable SLN nodes (feasibility) but increase the chance of encountering aberrant lymph drainage patterns such as bilateral SLNs in lateral tumours or SLNs at unexpected locations. Read More

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History and Updates of the GROINSS-V Studies.

Cancers (Basel) 2022 Apr 13;14(8). Epub 2022 Apr 13.

Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.

Surgical management of vulvar cancer is associated with high morbidity rates. The main aim of the GROINSS-V studies is reducing treatment-related morbidity by finding safe alternative treatment options in early-stage vulvar cancer patients. This article reviews the history, results, and updates of the GROINSS-V studies. Read More

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The Paget Trial: topical 5% imiquimod cream for noninvasive vulvar Paget disease.

Am J Obstet Gynecol 2022 Apr 18. Epub 2022 Apr 18.

Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands.

Background: Vulvar Paget disease is an extremely rare skin disorder, which is most common in postmenopausal women. Most vulvar Paget disease cases are noninvasive; however, it may be invasive or associated with an underlying vulvar or distant adenocarcinoma. The current treatment of choice for noninvasive vulvar Paget disease is wide local excision, which is challenging because of extensive intraepithelial spread and may cause severe morbidity. Read More

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Management of secondary Paget's disease of the vulva associated with transitional cell carcinoma.

J Cancer Res Clin Oncol 2022 Jul 17;148(7):1697-1702. Epub 2022 Apr 17.

Department of Gynecologic Oncology, University of Vermont Medical Center, Burlington, VT, USA.

Purpose: Secondary extramammary Paget's disease (EMPD) related to urothelial carcinoma is rare, with some cases presenting synchronously with either a primary neoplasm or recurrence of a neoplasm and other cases presenting up to 13 years prior to the detection of urothelial carcinoma. In this report, we will review the presentation, diagnosis, pathophysiology, management, and literature review of cases of secondary EPMD associated with urothelial carcinoma.

Methods: We reviewed the English literature for all cases of secondary EMPD presenting synchronously with or in patients with a history of urothelial carcinoma, as well as treatment data for secondary vulvar Paget's. Read More

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[Radiotherapy versus inguinofemoral lymphadenectomy in vulvar cancer patients with micrometastases in the sentinel node].

Strahlenther Onkol 2022 Jun 12;198(6):595-597. Epub 2022 Apr 12.

Klinik für Radioonkologie, CyberKnife und Strahlentherapie, Univ.-Klinik zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

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Epithelioid leiomyosarcoma of the vulva: report of a rare case and literature review.

J Int Med Res 2022 Apr;50(4):3000605221090473

Department of Gynaecology and Obstetrics, The First Hospital of Jilin University, Changchun, Jilin Province, China.

Leiomyosarcoma of the vulva is a rare soft tissue sarcoma that accounts for approximately 1% of all primary vulvar neoplasms, but it is the most common type of vulvar sarcoma. It usually originates from the smooth muscle within erectile tissue or blood vessel walls, the round ligament, the dartos muscle or the arrector pili muscle. No treatment algorithms have been established to date. Read More

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Pelvic Exenteration for the Treatment of Locally Advanced Vulvar Cancer in South West Wales.

Cancers (Basel) 2022 Mar 31;14(7). Epub 2022 Mar 31.

Swansea Gynaecological Oncology Centre, Department of Obstetrics and Gynaecology, Swansea Bay University Health Board, Swansea SA2 8QA, UK.

The treatment of locally advanced vulvar carcinoma (LAVC) represents a major challenge. We investigated the role of pelvic exenteration as a treatment of LAVC. Women who underwent pelvic exenteration for primary and recurrent LAVC in our centre between 2001 and 2019 were included. Read More

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Reconstructive Surgery versus Primary Closure following Vulvar Cancer Excision: A Wide Single-Center Experience.

Cancers (Basel) 2022 Mar 26;14(7). Epub 2022 Mar 26.

Department of Gynecology with Center for Oncological Surgery, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Virchow Campus Clinic, Charité Medical University, 13353 Berlin, Germany.

(1) Background: plastic reconstruction in vulvar surgery can lead to a better treatment outcome than primary closure. This study aims to compare the preoperative parameters (co-morbidities and tumor size) and postoperative results (tumor free margins and wound healing) between the primary closure and reconstructive surgery after vulvar cancer surgery; (2) Methods: this is a retrospective analysis of prospectively collected data from 2009 to 2021 at a tertiary cancer institution; (3) Results: 177 patients were included in the final analysis (51 patients had primary closure PC and 126 had reconstructive surgery RS). About half (49%) of the PC patients had no co-morbidities ( = 0. Read More

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Ten years of live surgical broadcast at Charité-MAYO conferences (2010-2019): a systematic evaluation of the surgical outcome.

Int J Gynecol Cancer 2022 Jun 6;32(6):746-752. Epub 2022 Jun 6.

Department of Gynecology with Center of Oncological Surgery, Charité Universitätsmedizin Berlin, Campus Virchow, Berlin, Germany.

Objective: The international Charité-MAYO Conference aims to promote international dialog on diagnostics, management, scientific breakthroughs, and state-of-the-art surgical procedures in gynecology and gynecologic oncology and senology. Live surgeries are a fundamental tool of interdisciplinary and international exchange of experts in their respective fields. Currently, there is a controversial and emotional debate about the true value, risks, and safety of live surgical broadcasts. Read More

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Vulvar cancer during pregnancy and/or breastfeeding: a report of five cases from a single center study at the University Hospital of Düsseldorf.

BMC Pregnancy Childbirth 2022 Mar 15;22(1):207. Epub 2022 Mar 15.

Department of Obstetrics and Gynecology, The Heinrich Heine University Hospital of Duesseldorf, Moorenstraße 5, 40225, Duesseldorf, Nordrhein-Westfalen, Germany.

Background: The incidence of vulvar cancer (VC) in pregnancy is unknown due to its rarity; between 1955 and 2014 only 36 case reports were reported worldwide. Underreporting may also be a contributing factor to the unknown incidence of VC in pregnancy. The aim of this study was to analyze the diagnosis, treatment and outcome of vulvar cancer cases diagnosed during pregnancy and/or breastfeeding. Read More

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Risk of Development of Vulvar Cancer in Women With Lichen Sclerosus or Lichen Planus: A Systematic Review.

J Low Genit Tract Dis 2022 Jul 11;26(3):250-257. Epub 2022 Mar 11.

Research Institute of the Azrieli Faculty of Medicine, Bar-Ilan University, Galilee Medical Center, Safed, Israel.

Objective: Vulvar lichen sclerosus (VLS) and possibly vulvar lichen planus (VLP) are associated with an increased vulvar cancer (VC) risk. We analyzed the risk of VC and its precursors after a diagnosis of VLS or VLP.

Materials And Methods: A search was performed to identify articles describing the development of vulvar neoplasia in women with VLS or VLP. Read More

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Adenoid Cystic Carcinoma of Bartholin's Gland: A Case Report with Emphasis on Surgical Management.

Am J Case Rep 2022 Mar 9;23:e935707. Epub 2022 Mar 9.

Department of Obstetrics and Gynecology, Lucerne Cantonal Hospital, Lucerne, Switzerland.

BACKGROUND Adenoid cystic carcinomas of Bartholin's gland are rare among gynecological malignancies, accounting for 0.1% to 7% of vulvar carcinomas and 0.001% of all female genital tract malignancies. Read More

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Aminolevulinate photodynamic therapy (ALA-PDT) combined with fire needle for vulva lymphangioma circumscriptum.

Photodiagnosis Photodyn Ther 2022 Jun 5;38:102797. Epub 2022 Mar 5.

Department of Dermato-venereology, the Second Hospital, Cheeloo college of Medicine, Shandong University, Jinan, China. Electronic address:

Lymphangioma is a rare benign lymphatic system proliferation, especially in the vulva. The general treatment principle is determined by clinical manifestations, lesion size, anatomic location, and complications. Treatment options include surgical excision, carbon dioxide laser, cryotherapy, electrocoagulation, and sclerosing agent injection. Read More

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Metastatic Neoplasms to the Vulva-A Review.

J Low Genit Tract Dis 2022 Apr;26(2):152-155

Department of Pathology, Immunology and Laboratory Medicine, Rutgers-New Jersey Medical School, Newark, NJ.

Introduction: Metastatic neoplasms to the vulva are rare and can pose a diagnostic dilemma. As identification of the primary site can influence patient treatment and prognosis, correct diagnosis is important.

Methods: PubMed was searched for applicable publications using the terms vulva, vulvar neoplasms, metastasis, and vulvar metastasis. Read More

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Postoperative management of vulvar cancer.

Int J Gynecol Cancer 2022 03;32(3):338-343

Radiation Oncology, Princess Margaret Hospital Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada

The primary treatment for resectable vulvar cancer includes wide local excision of the primary tumor and surgical lymph node assessment. Following surgery, up to 40-50% of patients develop a local recurrence. Historically, the strongest predictor of local recurrence is a positive or close margin (defined as <8 mm), although recent studies question the importance of margin status. Read More

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Definitive chemoradiation or radiation therapy alone for the management of vulvar cancer.

Int J Gynecol Cancer 2022 03;32(3):332-337

Allegheny Health Network, Pittsburgh, Pennsylvania, USA

Vulvar cancer is rare, and unresectable disease provides a therapeutic conundrum. Although definitive surgery remains the mainstay for curative treatment of vulvar cancer, a minority of patients present with advanced disease for which surgical resection would be extraordinarily morbid. Pre-operative and definitive radiation with radiosensitizing systemic therapy allows such patients an opportunity for cure. Read More

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A Systematic Review of Risk Factors for Development, Recurrence, and Progression of Vulvar Intraepithelial Neoplasia.

J Low Genit Tract Dis 2022 Apr;26(2):140-146

British Columbia Centre for Vulvar Health, Vancouver, Canada.

Objective: Vulvar intraepithelial neoplasia (VIN) is a premalignant condition with high recurrence rates despite treatment. Vulvar intraepithelial neoplasia develops through separate etiologic pathways relative to the presence or absence of human papillomavirus (HPV) and TP53 mutations. This systematic review was conducted (1) to identify historical risk factors for the development, recurrence, and progression of VIN and (2) to critique these risk factors in the context of advances made in the stratification of VIN based on HPV or TP53 status. Read More

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Sebaceous Carcinoma of the Vulva: An Unexpected Diagnosis and Literature Review.

Acta Med Port 2022 Jan 3;35(1):63-67. Epub 2022 Jan 3.

Serviço de Ginecologia. Instituto Português de Oncologia de Coimbra. Coimbra. Portugal.

Sebaceous carcinoma of the vulva is a rare malignancy of the sebaceous glands, with potentially aggressive behaviour, that is usually found in the peri-ocular area. Nonetheless, there are sebaceous glands in the vulva and this diagnosis is especially rare, with only ten cases described in the literature. We report a case of 78-year-old female patient who presented with vulvar pruritus, previously treated with topical steroid and antifungal treatments, without improvement. Read More

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January 2022

Impact of the COVID-19-pandemic on patients with gynecological malignancies undergoing surgery: A Dutch population-based study using data from the 'Dutch Gynecological Oncology Audit'.

Gynecol Oncol 2022 05 22;165(2):330-338. Epub 2022 Feb 22.

Dutch Institute for Clinical Auditing (DICA), Scientific Bureau, Leiden, the Netherlands; Netherlands Cancer Institute, Department of Surgical Oncology, Amsterdam, the Netherlands; Leiden University Medical Center, Leiden, the Netherlands.

Objective: The COVID-19-pandemic caused drastic healthcare changes worldwide. To date, the impact of these changes on gynecological cancer healthcare is relatively unknown. This study aimed to assess the impact of the COVID-19-pandemic on surgical gynecological-oncology healthcare. Read More

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