2,986 results match your criteria Surgical Treatment of Vulvar Cancer


Multidisciplinary personalized approach in the management of vulvar cancer - the Vul.Can Team experience.

Int J Gynecol Cancer 2020 May 30. Epub 2020 May 30.

Unità Operativa di Radioterapia, Gemelli Molise Hospital, Campobasso, Molise, Italy.

Introduction: Multidisciplinary treatment strategy involving adjuvant radiotherapy for advanced vulvar cancer could be useful in offering the best personalized clinical approach. In 2013, the VULvar CANcer Multi-Disciplinary Team (Vul.Can MDT) was set up in our institution, in order to share knowledge and expertise, high-quality diagnosis, and evidence-based decision making in the context of personalized medicine. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001465DOI Listing

Practical recommendations for gynecologic surgery during the COVID-19 pandemic.

Int J Gynaecol Obstet 2020 May 29. Epub 2020 May 29.

Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCCS-Regina Elena National Cancer Institute, Rome, Italy.

Surgery in suspected/confirmed COVID-19 patients is a high-risk venture. In infected patients, COVID-19 is present in the body cavity. During surgery it could be nebulized in the spray generated by surgical instruments and could theoretically infect members of the surgical team. Read More

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http://dx.doi.org/10.1002/ijgo.13248DOI Listing

Quality of life and associated factors after surgical treatment of vulvar cancer by vulvar field resection (VFR).

Arch Gynecol Obstet 2020 Jul 19;302(1):191-201. Epub 2020 May 19.

Department of Gynecology, University Hospital Leipzig, Liebigstr. 20a, 04103, Leipzig, Germany.

Purpose: To investigate patient-reported quality of life (QoL) and associated factors in vulvar cancer patients treated surgically by vulvar field resection (VFR) without adjuvant radiation.

Methods: We retrospectively evaluated patient-reported QoL as part of the prospective monocentric VFR trial using the 30-item European Organization for Research and Treatment of Cancer quality-of-life questionnaire (EORTC QLQ-C30) supplemented by a question assessing sexual activity. All patients had been treated by VFR and no participant had received adjuvant radiotherapy. Read More

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http://dx.doi.org/10.1007/s00404-020-05584-5DOI Listing

Adenoid Cystic Carcinoma of Bartholin's Gland: What Is the Best Approach?

Oncology 2020 May 14:1-7. Epub 2020 May 14.

National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.

Background and summary: Among all vulvar cancers, primary adenoid cystic carcinoma (ACC) of Bartholin's gland is a very rare tumor characterized by a slow growth, a high local aggressiveness, and a remarkable recurrence rate. Due to its rarity, treatment remains a challenge for oncologists and gynecological surgeons. Key message: The present paper reports clinical, radiological, and histological features of ACC of Bartholin's gland and reviews the literature data on the treatment options with a particular focus on the potential role of particle radiation therapy. Read More

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http://dx.doi.org/10.1159/000506485DOI Listing

Vulvar cancer: surgical management and survival trends in a low resource setting.

J Egypt Natl Canc Inst 2020 Jan 14;32(1). Epub 2020 Jan 14.

Department of Surgical Oncology, Dr. BRA-IRCH, All India Institute of Medical Sciences, New Delhi, India.

Background: This study aims to analyze risk factors, clinical profiles, treatment protocols, and disease outcomes in histologically proven resectable vulvar cancer (VC) patients according to tumor stage. This is a retrospective analysis of a prospectively collected database of 20 VC patients from May 2014 to June 2019.

Results: The mean age of VC diagnosis was 55 years, with a range of 38-84 years. Read More

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http://dx.doi.org/10.1186/s43046-019-0015-yDOI Listing
January 2020

Complication rates and lymph node count between two different skin incisions at time of inguino-femoral lymph node dissection in vulvar cancer.

Int J Gynecol Cancer 2020 May 4. Epub 2020 May 4.

Gynaecological Oncology, University Hospital of Wales, Cardiff, UK.

Introduction: Inguino-femoral lymph node dissection plays a crucial role in the management of vulvar cancer. The procedure is associated with high complication rates, including infection, lymphocysts/lymphoedema and wound dehiscence. Several skin incision techniques exist and practice among gynecology oncologists is variable. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001014DOI Listing

Molecular pathways in vulvar squamous cell carcinoma: implications for target therapeutic strategies.

J Cancer Res Clin Oncol 2020 Jul 25;146(7):1647-1658. Epub 2020 Apr 25.

Unità di Ginecologia Oncologica, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168, Rome, Italy.

Background: Additional prognostic factors and personalized therapeutic alternatives for vulvar squamous cell carcinoma (VSCC), especially for advanced stages with poor prognosis, are urgently needed.

Objectives: To review and assess literature regarding underlying molecular mechanisms of VSCC target therapeutic and prognostic approaches.

Methods: We performed a narrative literature review from the inception of the database up to January 2020 limited to English language, organizing knowledge in five main fields: extracellular and intracellular cell cycle deregulation, tumor immune microenvironment, tumor angiogenesis and hormones. Read More

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http://dx.doi.org/10.1007/s00432-020-03226-6DOI Listing

Can radical surgical treatment of the vulva be justified in the absence of a conclusive diagnosis of squamous cell carcinoma on biopsy? A retrospective 10-year cohort study.

Eur J Obstet Gynecol Reprod Biol 2020 May 19;248:238-244. Epub 2020 Mar 19.

Department of Gynecologic Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands. Electronic address:

Objectives: The extent of surgical treatment for vulvar lesions is predominantly guided by the histopathologic diagnosis rendered on the pre-operative biopsy. For premalignant lesions, local excisions are performed, whereas for vulvar squamous cell carcinoma (VSCC), more radical procedures are mandatory. However, even in the absence of a conclusive diagnosis of VSCC on biopsy, the surgeon may opt for a radical excision on grounds of strong clinical suspicion, with a view to avoiding repeat surgeries. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.03.027DOI Listing

Expert consensus from the Italian Society for Colposcopy and Cervico-Vaginal Pathology (SICPCV) for colposcopy and outpatient surgery of the lower genital tract during the COVID-19 pandemic.

Int J Gynaecol Obstet 2020 Jun 22;149(3):269-272. Epub 2020 Apr 22.

Department of Obstetrics and Gynecology, Asti Community Hospital, Asti, Italy.

In the context of the COVID-19 pandemic, patients need to be evaluated within 2-4 weeks in the following cases: cytology result of "squamous cell carcinoma," "atypical glandular cells, favor neoplastic," "endocervical adenocarcinoma in situ," or "adenocarcinoma"; histopathological diagnosis of suspected invasion from cervical/vaginal biopsy, or invasive disease after a cervical excision procedure, vaginal excision, or vulvar biopsy/excision; sudden onset of strongly suggestive symptoms for malignancy. Digital imaging technologies represent an important opportunity during the COVID-19 pandemic to share colposcopic images with reference centers, with the aim of avoiding any concentration of patients. All patients must undergo screening for COVID-19 exposure and should wear a surgical mask. Read More

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http://dx.doi.org/10.1002/ijgo.13158DOI Listing

Recommendations for the surgical management of gynecological cancers during the COVID-19 pandemic - FRANCOGYN group for the CNGOF.

J Gynecol Obstet Hum Reprod 2020 Jun 1;49(6):101729. Epub 2020 Apr 1.

Service de gynécologie obstétrique, HôpitalTenon, 75020 Paris, France.

Introduction: In the context of the COVID-19 pandemic, specific recommendations are required for the management of patients with gynecologic cancer.

Materials And Method: The FRANCOGYN group of the National College of French Gynecologists and Obstetricians (CNGOF) convened to develop recommendations based on the consensus conference model.

Results: If a patient with a gynecologic cancer presents with COVID-19, surgical management should be postponed for at least 15 days. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118621PMC

The effect of lymph node metastasis on overall survival and disease-free survival in vulvar cancer patients.

Ginekol Pol 2020 ;91(2):62-67

Department of Gynecologic Oncology,University of Health Sciences Tepecik Education and Research Hospital, İzmir, Turkey.

Objectives: To examine the effect of lymphadenectomy on survival in patients with squamous cell vulvar carcinoma.

Material And Methods: Patients with squamous cell vulvar cancer who underwent surgery were retrospectively analyzed. All procedures were performed according to current recommendations/standard of treatment. Read More

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http://dx.doi.org/10.5603/GP.2020.0018DOI Listing
January 2020

Report from the 21st meeting of the European Society of Gynaecological Oncology (ESGO 2019).

Int J Gynecol Cancer 2020 Apr 5;30(4):441-447. Epub 2020 Mar 5.

Gynaecologic Oncology, Holycross Cancer Centre, Kielce, Poland.

This is a report from the 21st Meeting of the European Society of Gynaecological Oncology (ESGO 2019) held in Athens, Greece, November 2-5, 2019. The conference offered state of the art educational sessions, and oral and poster abstract presentations. The general sessions throughout the meeting focused not only on prevention, screening, diagnosis, treatment, and translational research but also on emerging trends. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001226DOI Listing
April 2020
1.949 Impact Factor

The Use of Both Therapeutic and Prophylactic Vaccines in the Therapy of Papillomavirus Disease.

Front Immunol 2020 18;11:188. Epub 2020 Feb 18.

Department of Biology and Biotechnology "C. Darwin," Sapienza University, Rome, Italy.

Human papillomavirus (HPV) is the most common sexually transmitted virus. The high-risk HPV types (i.e. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040023PMC
February 2020

Evolution and outcomes of sentinel lymph node mapping in vulvar cancer.

Int J Gynecol Cancer 2020 Mar 18;30(3):383-386. Epub 2020 Feb 18.

Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York City, New York, USA.

Objectives: To characterize our institutional experience with sentinel lymph node (SLN) biopsy in patients with vulvar cancer. We describe the oncologic outcomes of these patients and the utilization of SLN detection techniques over time.

Methods: A retrospective analysis of all patients who underwent inguinofemoral SLN biopsy as part of their treatment for vulvar cancer at Memorial Sloan Kettering Cancer Center from January 1, 2000 to April 1, 2019. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000936DOI Listing

Immune checkpoint status and tumor microenvironment in vulvar squamous cell carcinoma.

Virchows Arch 2020 Jan 28. Epub 2020 Jan 28.

Department of Pathology, The University of Alabama at Birmingham, West Pavilion P210, 619 19th Street, South Birmingham, AL, 35249-7331, USA.

Vulvar squamous cell carcinoma accounts for 5% of cancers of the female genital tract. Current guidelines recommend wide local excision with negative surgical margins as the standard treatment. However, the extent of the tumor-free resection margin after wide local excision is still controversial in many cases. Read More

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http://dx.doi.org/10.1007/s00428-020-02759-yDOI Listing
January 2020
2.651 Impact Factor

Current and novel mapping substances in gynecologic cancer care.

Int J Gynecol Cancer 2020 Mar 17;30(3):387-393. Epub 2020 Jan 17.

Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

Many tracers have been introduced into current medical practice with the purpose of improving lymphatic mapping techniques, anatomic visualization, and organ/tissue perfusion assessment. Among them, three tracers have dominated the field: indocyanine green, technetium-99m radiocolloid (Tc99), and blue dye. Tc99 and blue dye are used individually or in combination; however, given particular challenges with these tracers, such as the need for a preoperative procedure by nuclear medicine and cost, other options have been sought. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001078DOI Listing

Potential targets for tumor-specific imaging of vulvar squamous cell carcinoma: A systematic review of candidate biomarkers.

Gynecol Oncol 2020 Mar 9;156(3):734-743. Epub 2020 Jan 9.

Centre for Human Drug Research, Zernikedreef 8, 2333CL Leiden, the Netherlands; Department of Gynecology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands. Electronic address:

Introduction: Vulvar squamous cell carcinoma (VSCC) is a rare malignancy with an increasing incidence, especially in young women. Surgical treatment of VSCC is associated with significant morbidity and high recurrence rates, which is related to the limited ability to distinguish (pre)malignant from healthy tissue. There is a need for new tools for specific real-time detection of occult tumor lesions and localization of cancer margins in patients with VSCC. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.12.030DOI Listing

Short-Term Surgical Outcomes of Standard and Lateral Video Endoscopic Inguinal Lymphadenectomy: A Multinational Retrospective Study.

J Laparoendosc Adv Surg Tech A 2020 Apr 10;30(4):373-377. Epub 2020 Jan 10.

Fortis Hospital, Bangalore, India.

Video endoscopic inguinal lymphadenectomy (VEIL) is a minimally invasive technique that gives superior surgical outcomes than open inguinal lymphadenectomy (IL) for treating lymph node metastasis in penile, vulvar, and skin cancers. This study compared surgical outcomes obtained with two different approaches of VEIL, standard VEIL and lateral VEIL (L-VEIL), in cancer patients. Sixty-two patients who underwent standard VEIL ( = 15) or L-VEIL ( = 47) for treatment of lymph node metastasis were evaluated retrospectively from three centers in Brazil, Egypt, and India. Read More

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http://dx.doi.org/10.1089/lap.2019.0733DOI Listing

Lower extremity lymphedema in patients with gynecologic malignancies.

Int J Gynecol Cancer 2020 02 7;30(2):252-260. Epub 2020 Jan 7.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York City, New York, USA

Lower extremity lymphedema is a chronic, often irreversible condition that affects many patients treated for gynecologic malignancies, with published rates as high as 70% in select populations. It has consistently been shown to affect multiple quality of life metrics. This review focuses on the pathophysiology, incidence, trends, and risk factors associated with lower extremity lymphedema secondary to the treatment of cervical, endometrial, ovarian, and vulvar cancers in the era of sentinel lymph node mapping. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001032DOI Listing
February 2020

Carcinoma vulva patterns of recurrence and treatment outcomes: A single-institution experience.

J Cancer Res Ther 2019 Oct-Dec;15(6):1328-1331

Department of Radiation Oncology and Surgical Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.

Aim: The aim of this study was to evaluate the patterns of recurrence and outcomes in patients with vulvar cancer treated with surgery, with or without postoperative radiotherapy (RT) or RT alone.

Materials And Methods: The hospital records were retrospectively analyzed from February 2007 to May 2016. All patients that had biopsy-proven carcinoma vulva were included for analysis. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_44_18DOI Listing

Risk Factors for Postoperative Complications After Vulvar Surgery.

In Vivo 2020 Jan-Feb;34(1):447-451

Department of Obstetrics and Gynecology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Background/aim: Although the trends of surgical treatment in vulvar cancer patients are towards less extended resections, a significant number of cases are still diagnosed with locally advanced diseases imposing performing extended resections. The aim of this paper is to identify the prognostic factors for the development of early postoperative complications following vulvar surgery.

Patients And Methods: Between 2017 and 2019, 145 patients with vulvar cancer were submitted to surgery with a curative intent. Read More

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http://dx.doi.org/10.21873/invivo.11794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984068PMC
October 2019

The International Society for the Study of Vulvovaginal Disease Surgical Oncological Procedure Definitions Committee "Surgical Terminology for Vulvar Cancer Treatment".

J Low Genit Tract Dis 2020 Jan;24(1):62-68

Department of Obstetrics and Gynaecology, University of Torino, Torino, Italy.

Objectives: The International Society for the Study of Vulvovaginal Disease (ISSVD) Surgical Oncological Procedure Definitions Committee propose a consistent terminology based on well-defined and reproducible anatomic landmarks that can be used by all who are involved in care of patients with vulvar conditions.

Materials And Methods: The fundamental principles behind the new terminology contained descriptions of the area extension and depth of the surgical procedure.

Results: Vulvar Surgical Topographic Anatomy LandmarksExtension. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000501DOI Listing
January 2020

GOG 244-The lymphedema and gynecologic cancer (LEG) study: Incidence and risk factors in newly diagnosed patients.

Gynecol Oncol 2020 02 16;156(2):467-474. Epub 2019 Dec 16.

Northwell Health Cancer Institute, 1111 Marcus Avenue, New Hyde Park, NY, 11042, USA. Electronic address:

Objectives: To evaluate the incidence and risk factors for lymphedema associated with surgery for gynecologic malignancies on GOG study 244.

Methods: Women undergoing a lymph node dissection for endometrial, cervical, or vulvar cancer were eligible for enrollment. Leg volume was calculated from measurements at 10-cm intervals starting 10 cm above the bottom of the heel to the inguinal crease. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018616PMC
February 2020

Vulvar malignancies: an interdisciplinary perspective.

J Dtsch Dermatol Ges 2019 Dec 12;17(12):1257-1276. Epub 2019 Dec 12.

Department of Dermatology, Paracelsus Medical University Salzburg, Austria.

Vulvar cancer represents the fourth most common gynecologic malignancy and is often encountered by the general Dermatologist or Gynecologist. Dermatooncologists and Gynecologic Oncologists share expertise in this field and the diagnosis and treatment should ideally be interdisciplinary. All subtypes are typically seen in the later decades of life, although all histologic subtypes have been described in women younger than 30 years. Read More

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http://dx.doi.org/10.1111/ddg.13995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972795PMC
December 2019
5 Reads

Can we extend the indication for sentinel node biopsy in vulvar cancer? A nationwide feasibility study from Sweden.

Int J Gynecol Cancer 2020 Mar 2;30(3):402-405. Epub 2019 Dec 2.

Obstetrics and Gynecology, Linkopings Universitet Institutionen for klinisk och experimentell medicin, Linkoping, Sweden.

Background: In squamous cell vulvar cancer, sentinel node biopsy is accepted as standard treatment in well-defined patient groups and has reduced surgical morbidity considerably. Currently, due to the lack of evidence, it cannot be offered to patients with tumors of 4 cm diameter or greater or with multifocal tumors, or in local recurrences.

Primary Objective: This study is primarily a pilot and feasibility trial, aiming to evaluate if the prerequisites concerning detection rate and negative predictive value are satisfactory before the implementation of a multinational trial. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000938DOI Listing

Changes in the Clinicopathological Demographics of Vulvar Cancer in Japan: Increasing Oldest-Old, Stage Shifting, and Decreasing Cohort-Level Survival .

J Clin Med 2019 Nov 29;8(12). Epub 2019 Nov 29.

Department of Obstetrics and Gynecology, Tokai University Hospital, Isehara, Kanagawa 259-1193, Japan.

Background: To examine trends in the clinicopathological characteristics of vulvar cancer in Japan.

Methods: This is a nationwide retrospective study examining consecutive women with vulvar cancer between 2001 and 2010 in Japan ( = 1061). Temporal trends in demographics, tumor characteristics, and survival were assessed by cohort-level analysis. Read More

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http://dx.doi.org/10.3390/jcm8122081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947365PMC
November 2019

Squamous cell carcinoma of the vulva diagnosed by a dermatologist.

An Bras Dermatol 2019 Nov - Dec;94(6):771-772. Epub 2019 Nov 6.

Department of Pathology, Instituto Lauro de Souza Lima, Bauru, SP, Brazil.

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http://dx.doi.org/10.1016/j.abd.2019.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939177PMC
January 2020

Malignant Melanoma of the Vulva and Vagina: A US Population-Based Study of 1863 Patients.

Am J Clin Dermatol 2020 Apr;21(2):285-295

Division of Gynecologic Oncology, Department of Surgical Oncology, University Health Network, Toronto, ON, Canada.

Background: Vulvar melanoma (VuM) and vaginal melanoma (VaM) represent a unique subgroup of malignant melanomas with important differences in biology and treatment.

Objective: The objective of this study was to describe the epidemiology and prognosis of VuM and VaM in a large representative cohort.

Methods: Women with invasive VuM or VaM were identified from the Surveillance, Epidemiology and End Results-18 population representing 27. Read More

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http://dx.doi.org/10.1007/s40257-019-00487-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125071PMC

Extramammary Paget disease of the vulva: Management and prognosis.

Gynecol Oncol 2020 Apr 25;157(1):146-150. Epub 2019 Nov 25.

Division of Gynecologic Oncology, Penn Medicine, Philadelphia, PA, USA.

Objective: To evaluate the clinicopathological characteristics, management and prognosis of patients with vulvar extramammary Paget disease of the vulva (EMPD).

Materials And Methods: The U.S National Cancer Database was accessed and patients diagnosed between 2004 and 2015 with microscopically confirmed vulvar EMPD were selected. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.11.009DOI Listing

Association of human papilloma virus status and response to radiotherapy in vulvar squamous cell carcinoma.

Int J Gynecol Cancer 2020 01 25;30(1):100-106. Epub 2019 Nov 25.

Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada

Introduction: Vulvar squamous cell carcinoma develops through two separate pathways, associated with the presence or absence of high-risk human papilloma virus (HPV). The objective of this study was to evaluate treatment response and clinical outcomes in women with HPV-associated versus HPV-independent vulvar squamous cell carcinoma treated with primary radiation therapy, in order to determine the ability to use HPV status as a predictor of response to radiation therapy.

Methods: This was a retrospective cohort study combining data from British Columbia Cancer, Canada and Duke University, USA. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000793DOI Listing
January 2020

High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity.

Gynecol Oncol 2020 02 23;156(2):349-356. Epub 2019 Nov 23.

Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Electronic address:

Introduction: To evaluate clinical outcomes, pattern of failure, and toxicity after high-dose intensity-modulated radiation therapy (IMRT) for advanced vulvar cancer.

Methods: In this IRB approved retrospective study, the charts of women with histologically confirmed, non-metastatic vulvar cancer consecutively treated at our institution from 2012 to 2018 were reviewed to identify patients that received high-dose IMRT with curative intent. The treatment compliance, toxicities, and patterns of failure were investigated. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.11.027DOI Listing
February 2020
3.774 Impact Factor

Surgical Treatment for Locally Advanced Adenoid Cystic Carcinoma of the Bartholin's Gland: A Case Report.

Authors:
Hiroshi Yoshida

Tokai J Exp Clin Med 2019 Dec 20;44(4):68-72. Epub 2019 Dec 20.

Department of Obstetrics and Gynecology, Yokohama Municipal Citizen's Hospital, 56 Okazawa-cho, Hodogaya-ku, Yokohama 240-8555, Japan.

Adenoid cystic carcinoma (ACC) of the Bartholin's gland (BACC) is an extremely rare malignancy of the vulva. The characteristics of BACC include slow tumor growth and aggressive invasion, especially with perineural involvement. A 64-year-old Japanese woman complained of a mass and pain in the perineum. Read More

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December 2019

Recurrence and survival rates in node negative patients after sentinel node biopsy for early-stage vulva cancer - A nationwide study.

Gynecol Oncol 2020 01 9;156(1):124-130. Epub 2019 Nov 9.

Department of Gynecology, Copenhagen University Hospital Rigshospitalet, Denmark.

Objective: The sentinel node (SN) procedure is adopted in selected patients with early-stage vulva cancer (VC) in Denmark. Due to the low incidence of VC, large population-based studies on the safety of SN outside multicenter clinical trials are lacking. The current study evaluated the risk of recurrence and survival in SN- negative VC patients. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.10.024DOI Listing
January 2020

Vulvar myeloid sarcoma as the presenting symptom of acute myeloid leukemia: a case report and literature review of Chinese patients, 1999-2018.

Diagn Pathol 2019 Nov 7;14(1):126. Epub 2019 Nov 7.

Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.

Background: Myeloid sarcoma (MS), which represents a rare malignancy that comprises of myeloid blasts occurring at extra-medullary sites, closely correlates with the onset and relapse of acute myeloid leukemia (AML) and other hemopoietic neoplasm. Female genital system is an uncommon location of MS, with the vulvar MS being even rarer that only eight cases have been reported in English-written literature.

Case Presentation: A 47-year-old woman presented with chronic ulceration on her vulva for one and a half month. Read More

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http://dx.doi.org/10.1186/s13000-019-0892-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839179PMC
November 2019

GOG 244 - The LymphEdema and Gynecologic cancer (LEG) study: The association between the gynecologic cancer lymphedema questionnaire (GCLQ) and lymphedema of the lower extremity (LLE).

Gynecol Oncol 2019 12 31;155(3):452-460. Epub 2019 Oct 31.

Program in Public Health, University of California, Irvine, Irvine, CA, USA; Department of Medicine, Division of Hematology/Oncology, University of California, Irvine, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, USA. Electronic address:

Objective: To explore whether patient-reported lymphedema-related symptoms, as measured by the Gynecologic Cancer Lymphedema Questionnaire (GCLQ), are associated with a patient-reported diagnosis of lymphedema of the lower extremity (LLE) and limb volume change (LVC) in patients who have undergone radical surgery, including lymphadenectomy, for endometrial, cervical, or vulvar cancer on Gynecologic Oncology Group (GOG) study 244.

Methods: Patients completed the baseline and at least one post-surgery GCLQ and LVC assessment. The 20-item GCLQ measures seven symptom clusters-aching, heaviness, infection-related, numbness, physical functioning, general swelling, and limb swelling. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900449PMC
December 2019

State of the art in vulvar cancer imaging.

Radiol Bras 2019 Sep-Oct;52(5):316-324

Radiology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal.

Vulvar carcinoma is an uncommon tumor that predominantly affects postmenopausal women. Currently, there is no screening procedure for vulvar carcinoma; in most cases, it is diagnosed only when symptoms appear. The most widely used staging system is that developed by the International Federation of Gynecology and Obstetrics. Read More

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http://dx.doi.org/10.1590/0100-3984.2018.0072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808606PMC
October 2019

Sentinel Node Mapping in Gynecologic Cancers: A Comprehensive Review.

Semin Nucl Med 2019 11 29;49(6):521-533. Epub 2019 Jun 29.

International Atomic Energy Agency, Vienna, Austria. Electronic address:

Gynecologic cancers are one of the most important causes of women death worldwide. The sentinel lymph node concept was introduced by Cabanas in 1977 for the penile cancer. This technique was proven safe and feasible in selected cancers such as breast cancer, melanoma, or some gynecologic cancers. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2019.06.012DOI Listing
November 2019
1 Read
3.342 Impact Factor

Modifield musculocutaneous gracilis flap A case report.

Ann Ital Chir 2019 Oct 9;8. Epub 2019 Oct 9.

A heterogeneous range of malignant pathologies affects vulvar and perineal regions. Today standard radical mutilating surgery for the treatment of invasive vulvar carcinoma is being replaced by a conservative and individualized approach. Defects of the external pelvis and perineal lining are usually reconstructed with local or regional fasciocutaneous flaps. Read More

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October 2019
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Post-hysterectomy rare collision vulva tumor with long-term human papilloma virus infection composed of squamous cell carcinoma of the labia major and adenosquamous carcinoma of bartholin gland: A case report.

Medicine (Baltimore) 2019 Sep;98(39):e17043

Department of Obstetrics & Gynaecology, West China Second Hospital.

Rationale: Post-hysterectomy collision tumors of the vulva has rarely been reported. Though long-term HPV infection may induce vulva tumor, but the relationship between HPV infection and collision vulva tumor is not clear. And there are no clear rules of the post-hysterectomy cancer surveillance for human papilloma virus (HPV) long-term infections. Read More

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http://dx.doi.org/10.1097/MD.0000000000017043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775373PMC
September 2019
2 Reads

[Cancer of the vulva: Diagnostic stages, treatment and survival in a country with limited resources (Burkina Faso)].

Bull Cancer 2019 Nov 18;106(11):1057-1063. Epub 2019 Sep 18.

Institut de cancérologie Joliot Curie de Dakar, Sénégal.

Introduction: Vulvar cancer is rare and belatedly diagnosed in Africa. We describe its diagnostic stages, therapeutic and evolution features in a country with limited resources.

Methodology: Forty-seven cases of vulvar cancer diagnosed between 2013 and 2018 in Burkina Faso, were analyzed retrospectively. Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.07.008DOI Listing
November 2019

[Use of Vacuum-Assisted Closure Therapy in the Treatment of Postoperative Inguinal Lymphocele after Lymphadenectomy for a Vulvar Apocrine Adenocarcinoma : A Case Report].

Hinyokika Kiyo 2019 Jul;65(7):309-313

The Department of Urology, Japan Red Cross Society Wakayama Medical Center.

A 79-year-old man with vulvar apocrine adenocarcinoma and right inguinal lymph node metastasis underwent wide excision and free skin graft reconstruction of the primary lesion and right inguinal lymphadenectomy. However, left inguinal lymph node metastasis was noted after 11 months, and left inguinal lymphadenectomy was performed. Twelve days postoperatively, the patient developed left inguinal lymphocele. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_65_7_309DOI Listing

Unilateral superficial external pudendal artery (SEPA) propeller perforator flap (PPF) for vulvar reconstruction after cancer treatment.

Eur J Obstet Gynecol Reprod Biol 2019 Oct 23;241:135-137. Epub 2019 Aug 23.

Department of Plastic, Reconstructive, and Aesthetic Surgery, Hôpital Sud, Rennes, France.

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http://dx.doi.org/10.1016/j.ejogrb.2019.08.006DOI Listing
October 2019

Efficacy and Safety of Lateral Approach-Video Endoscopic Inguinal Lymphadenectomy (L-VEIL) over Open Inguinal Block Dissection: a Retrospective Study.

Indian J Surg Oncol 2019 Sep 14;10(3):555-562. Epub 2019 Jun 14.

3Vice Chancellor, Yenepoya University, Mangalore, Karnataka India.

This retrospective study compared the immediate post-operative short-term outcomes of Lateral Approach-Video Endoscopic Inguinal Lymphadenectomy (L-VEIL) and open surgery approach in patients with TNM stage N0 and N1 tumors. Inguinal lymphadenectomies performed for various TNM stage N0 and N1 cancers between January 2011 and December 2015 at a single center were analyzed by collecting data from operation theater records and case files. Mean blood loss, operative time, drain output, nodal yield, nodal positivity, and complications were analyzed as post-procedural outcomes. Read More

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http://dx.doi.org/10.1007/s13193-019-00951-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708014PMC
September 2019
4 Reads

[Workup, treatment and follow-up of vulva cancer].

Ugeskr Laeger 2019 Aug;181(34)

This review summarises the current guidelines for vulva cancer in Denmark. Vulva cancer is a rare disease. The diagnosis is often delayed, which results in large tumours and regional spread. Read More

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Secondary healing strategy for difficult wound closure in invasive vulvar cancer: a pilot case-control study.

Clinics (Sao Paulo) 2019 2;74:e1218. Epub 2019 Sep 2.

Disciplina de Ginecologia, Departamento de Ginecologia e Obstetricia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: Despite the number of surgical advances and innovations in techniques over time, radical vulvectomy frequently results in substantial loss of tissue that cannot be primarily closed without tension, the mobilization of surrounding tissues or even the rotation of myocutaneous flaps. The aim of this study was to evaluate the feasibility of leaving the surgical vulvar open wound for secondary healing in situations where primary closure of the vulvar wound is not possible.

Methods: This case-control pilot study analyzed 16 women with a diagnosis of squamous cell carcinoma of the vulva who first underwent inguinofemoral lymphadenectomy, 6-week sessions of chemotherapy and 25 daily sessions of radiotherapy. Read More

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http://dx.doi.org/10.6061/clinics/2019/e1218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711258PMC
March 2020
2 Reads

Feasibility of sentinel lymph node mapping of the ovary: a systematic review.

Int J Gynecol Cancer 2019 09;29(7):1209-1215

Department of Obstetrics and Gynecology, Azienda Ospedaliera San Gerardo, Monza, Italy

Pelvic and para-aortic lymphadenectomy is routinely performed in early ovarian cancer to define the stage of the disease. However, it may be associated with increased blood loss, operative time, and length of hospitalization. The sentinel lymph node technique has been shown to be safe and feasible in vulvar, uterine, and cervical cancer. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000606DOI Listing
September 2019
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Management of genitourinary syndrome of menopause in female cancer patients: a focus on vaginal hormonal therapy.

Am J Obstet Gynecol 2020 02 29;222(2):103-113. Epub 2019 Aug 29.

Obstetrics/Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, OH.

Genitourinary syndrome of menopause is a condition describing the hypoestrogenic effects on the female genitals and lower urinary tract leading to symptoms such as vaginal dryness, vulvar and vaginal burning, dyspareunia and dysuria. Genitourinary syndrome of menopause is experienced by over half of postmenopausal women, and is even more pervasive in women with cancer. Due to treatments such as surgery, chemotherapy, radiation, and hormonal therapy, women may experience early menopause resulting in earlier and more severe symptoms. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.08.043DOI Listing
February 2020
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Practical Guidance for Measuring and Reporting Surgical Margins in Vulvar Cancer.

Int J Gynecol Pathol 2019 Aug 26. Epub 2019 Aug 26.

Departments of Obstetrics and Gynecology (K.E.K., M.I.E.V.P.) Pathology (V.T.H.B.M.S., T.B.), Leiden University Medical Centre, Leiden, The Netherlands Department of Pathology, Ghent University Hospital, Gent (K.K.V.D.V.) Department of Pathology, University Hospitals Leuven, Leuven (A.S.V.R.), Belgium Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada (C.B.G.) Department of Cellular Pathology, Princess Alexandra Hospital, Harlow, Essex (S.A.) Department of Cellular Pathology, St. James's University Hospital, Leeds (D.A.) Department of Cellular Pathology, Barts Health NHS Trust, London (A.F., N.S.) Department of Cellular Pathology, University Hospitals Birmingham NHS Trust, Birmingham (R.G., B.T., J.V.) Department of Pathology, Airedale General Hospital, Keighley (N.R.G.) Department of Cellular Pathology, Stepping Hill Hospital, Stockport (R.H.) Department of Histopathology, Manor Hospital, Walsall Healthcare NHS Trust, Walsall (Y.L.H.) Department of Pathology, Belfast Health and Social Care Trust, Belfast (W.G.M.) Department of Cellular Pathology, Royal United Hospital, Bath (P.M.) Department of Pathology, Cambridge University Hospitals NHS Trust, Cambridge (B.R.) Department of Pathology, Royal Derby Hospital, Derby (G.V.S) Department of Histopathology, The Royal Sussex County Hospital, Brighton (M.V.), UK Division of Gynecologic, Breast & Perinatal Pathology, University Hospital Leipzig, Leipzig, Germany (L.C.H.) Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (K.J.P.).

Surgical resection with free surgical margins is the cornerstone of successful primary treatment of vulvar squamous cell carcinoma (VSCC). In general reexcision is recommended when the minimum peripheral surgical margin (MPSM) is <8 mm microscopically. Pathologists are, therefore, required to report the minimum distance from the tumor to the surgical margin. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000631DOI Listing
August 2019
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Long term outcomes in patients with sentinel lymph nodes (SLNs) identified by injecting remaining scar after previously excised vulvar cancer.

Gynecol Oncol 2019 10 23;155(1):83-87. Epub 2019 Aug 23.

University of Toronto, Division of Gynecologic Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:

Background: Lymph node metastasis is the most important prognostic factor in patients with vulvar squamous cell carcinoma (SCC). Previous excision of the vulvar tumor may disrupt lymphatic channels and alter the accuracy of the sentinel lymph node (SLN) biopsy. The purpose of this study was to measure outcomes after SLN biopsy in patients with and without previous excision of the vulvar tumor. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.08.015DOI Listing
October 2019
2 Reads