2,845 results match your criteria Surgical Treatment of Vulvar Cancer


Robot-assisted sentinel lymph node mapping and inguinal lymph node dissection, using near-infrared fluorescence, in vulvar cancer.

J Minim Invasive Gynecol 2019 Apr 5. Epub 2019 Apr 5.

Department of Obstetrics and Gynecology (Drs. Mohammad and Hunter), University of Missouri, Columbia, MO. Electronic address:

The surgical treatment of vulvar cancer has undergone many changes over the last century. The morbidity of open inguinal incisions prompts the search for a minimally-invasive approach to lymph node dissection. This study reports the outcomes of four patients with vulvar cancer, undergoing robotic sentinel lymph node (SLN) mapping and lymph node (LN) dissection with near-infrared fluorescence. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.04.002DOI Listing
April 2019
1 Read

[Update regarding the management of vulvar cancer: The guidelines of the Assistance Publique-Hôpitaux de Paris].

Bull Cancer 2019 Apr 18;106(4):371-378. Epub 2019 Mar 18.

AP-HP, hôpital Pitié-Salpêtrière, service de chirurgie et oncologie gynécologique et mammaire, 75013 Paris, France. Electronic address:

Vulvar cancer is a rare disease, which represents 4% of gynecological tumors with an incidence of 0.5 to 1.5 per 100,000 women per year in France. Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.01.017DOI Listing
April 2019
1 Read

Efficacy of a collagen-fibrin sealant patch (TachoSil®) as adjuvant treatment in the inguinofemoral lymphadenectomy for vulvar cancer: a double-blind randomized-controlled trial.

Arch Gynecol Obstet 2019 May 11;299(5):1467-1474. Epub 2019 Mar 11.

Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, Piazzale A. Stefani 1, 37126, Verona, Italy.

Purpose: To evaluate the effect of a collagen-fibrin sealant patch (TachoSil®) in preventing postoperative complications after inguinofemoral lymphadenectomy for vulvar cancer.

Methods: Double-blind randomized-controlled trial on consecutive patients undergoing bilateral inguinofemoral lymphadenectomy for vulvar cancer. Intraoperatively, inguinofemoral areas were randomized: one was treated with TachoSil®, while the contralateral had standard closure without collagen-fibrin sealant patch. Read More

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http://dx.doi.org/10.1007/s00404-019-05113-zDOI Listing
May 2019
1 Read
1.279 Impact Factor

Vulvar itch.

BMJ 2019 Feb 7;364:l83. Epub 2019 Feb 7.

Belfast City Hospital, Belfast Health and Care Trust, Belfast, UK.

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http://dx.doi.org/10.1136/bmj.l83DOI Listing
February 2019
1 Read

Recurrent vulvar breast fibroadenoma: presentation of a rare clinical condition.

J Int Med Res 2019 Feb 8:300060519826771. Epub 2019 Feb 8.

1 Department of Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Vulvar fibroadenoma is an ectopic mammary-like fibroepithelial tumor of undetermined pathogenesis. Surgery is usually the primary option of treatment for this condition. Recurrent vulvar fibroadenoma is a rare clinical condition, and it has therapeutic challenges for surgeons and pathologists. Read More

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http://dx.doi.org/10.1177/0300060519826771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421365PMC
February 2019
5 Reads

Vulvar Cancer.

Obstet Gynecol Clin North Am 2019 Mar;46(1):125-135

Department of Obstetrics and Gynecology, University of New Mexico, MSC10 5580, 1 University of New Mexico, Albuquerque, NM 87131, USA.

This article reviews the epidemiology, diagnosis, and management of vulvar preinvasive lesions, squamous cell carcinoma, and melanoma. There is an emphasis on sentinel lymph node dissection for early stage disease and advances in chemoradiation for late-stage disease. A brief review of vulvar Paget disease is also included. Read More

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http://dx.doi.org/10.1016/j.ogc.2018.09.008DOI Listing
March 2019
8 Reads

The Situation of Cervical Cancers in the Context of Female Genital Cancer Clustering and Burden of Disease in Arad County, Romania.

J Clin Med 2019 Jan 15;8(1). Epub 2019 Jan 15.

Department of Obstetrics and Gynecology, Arad County Clinical Hospital, 310023 Arad, Romania.

Romania has the highest incidence of cervical cancer morbidity and mortality in Europe. This study identifies the major clusters for genital cancers, observes the features of genital and cervical cancer, and determines the extent to which cancer is a contributor to total Disability-Adjusted Life Year (DALY). Spatial analysis used Besag and Newell's method for genital cancer distribution, prevalence considered Arad County patients records (2008⁻2017), and DALY was determined according to WHO methodology and GLOBOCAN 2013 data. Read More

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http://www.mdpi.com/2077-0383/8/1/96
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http://dx.doi.org/10.3390/jcm8010096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351929PMC
January 2019
13 Reads

Superficially invasive stage IA vulvar squamous cell carcinoma-therapy and prognosis.

Int J Gynecol Cancer 2019 Mar 4;29(3):466-473. Epub 2019 Jan 4.

Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Objectives: Superficially invasive stage IA squamous vulvar cancer (VSCC) is defined as a single lesion measuring ≤2 cm with a depth of invasion of ≤1.0 mm (FIGO stage IA). This article examines the natural course and prognosis of superficially invasive VSCC. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000046DOI Listing
March 2019
23 Reads

No. 370-Management of Squamous Cell Cancer of the Vulva.

J Obstet Gynaecol Can 2019 Jan;41(1):89-101

Montréal, QC.

Objective: This guideline reviews the clinical evaluation and management of squamous cell cancer (SCC) of the vulva with respect to diagnosis, primary surgical, radiation, or chemotherapy management and need for adjuvant treatment with chemotherapy and/or radiation therapy. Other vulvar cancer pathologic diagnoses are not included in the guideline.

Intended Users: The first part of this document which includes recommendations 1 through 3 is for general gynaecologists, obstetricians, family doctors, registered nurses, nurse practitioners, residents, and health care providers with a focus on the presentation, diagnosis, and updated information about surgical procedures performed by subspecialists. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17012163183057
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http://dx.doi.org/10.1016/j.jogc.2018.07.004DOI Listing
January 2019
28 Reads

The age-adjusted Charlson comorbidity index as a predictor of survival in surgically treated vulvar cancer patients.

J Gynecol Oncol 2019 Jan 4;30(1):e6. Epub 2018 Oct 4.

Department of Gynecology Obstetrics Sciences and Urologic Sciences, Sapienza University of Rome, Rome, Italy.

Objective: To evaluate the impact of age-adjusted Charlson comorbidity index (ACCI) in predicting disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS) among surgically treated patients with vulvar carcinoma. The secondary aim is to evaluate its impact as a predictor of the pattern of recurrence.

Methods: We retrospectively evaluated data of patients that underwent surgical treatment for vulvar cancer from 1998 to 2016. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304403PMC
January 2019
5 Reads

Sentinel lymph nodes in vulvar cancer: Management dilemmas in patients with positive nodes and larger tumors.

Gynecol Oncol 2019 01 16;152(1):94-100. Epub 2018 Nov 16.

University of Toronto, Department of Obstetrics and Gynecology, Toronto, Ontario, Canada; Division of Gynecologic Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:

Background: Although sentinel lymph node (SLN) biopsy has been routinely used in the treatment of invasive squamous cell carcinoma (SCC), questions still remain regarding the management of patients with positive nodes, as well as its use in patients with larger tumors.

Methods: Retrospective study of all patients at a single institution with primary vulvar cancer who had SLN biopsy (2008-2015). Patient and tumor characteristics were collected from hospital records. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183136
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http://dx.doi.org/10.1016/j.ygyno.2018.10.047DOI Listing
January 2019
14 Reads

MRI evaluation of vulvar squamous-cell carcinoma in fresh radical local excision specimens for cancer localization and prediction of surgical tumor-free margins.

NMR Biomed 2019 Jan 15;32(1):e4025. Epub 2018 Nov 15.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

In the surgical treatment of vulvar squamous-cell carcinoma (VSCC), tumor-free margins of 8 mm or more are considered adequate. However, limited perioperative information on the tumor-free margins other than the surgeon's own estimation is available. The purpose of this study was therefore to investigate the feasibility of ex vivo MRI in localizing VSCC and to assess the surgical tumor-free margins in fresh radical local excision (RLE) specimens to guide the surgeon during resections. Read More

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http://doi.wiley.com/10.1002/nbm.4025
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http://dx.doi.org/10.1002/nbm.4025DOI Listing
January 2019
11 Reads

Melanoma of the Vulva and Vagina: Surgical Management and Outcomes Based on a Clinicopathologic Reviewof 68 Cases.

J Obstet Gynaecol Can 2018 Oct 31. Epub 2018 Oct 31.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON; Division of Gynecologic Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON.

Objective: This study sought to evaluate the clinicopathologic features, surgical management, and survival of patients over 12 years at two academic centres.

Methods: Patients diagnosed with vulvar or vaginal melanoma between 2002 and 2014 were identified through pathology databases. Clinical and pathologic data were extracted from the medical records. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17012163183058
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http://dx.doi.org/10.1016/j.jogc.2018.07.011DOI Listing
October 2018
8 Reads

Suprapubic catheterization is expedient for the surgical excision of female genital tumors.

Dermatol Ther 2018 11 28;31(6):e12732. Epub 2018 Oct 28.

Department of Urology, Itami City Hospital, Itami, Japan.

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http://dx.doi.org/10.1111/dth.12732DOI Listing
November 2018
2 Reads

Squamous cell carcinoma of the vulva: a review of present management and future considerations.

Expert Rev Anticancer Ther 2019 Jan 26;19(1):43-50. Epub 2018 Oct 26.

a Department of Obstetrics and Gynecology, Division of Gynecologic Oncology , Washington University School of Medicine, Alvin J. Siteman Cancer Center , St. Louis , MO , USA.

Introduction: Although a relatively uncommon disease, the treatment of vulvar cancer has changed considerably over the years and has been under considerable focus due to its past overtreatment and apparent increase in incidence. The purpose of this review is to describe the recommended management of the most commonly encountered vulvar carcinomas based on the most recent available literature. Areas covered: The clinical environment of squamous cell vulvar cancers are illustrated in order to describe the potential pitfalls and limitations of treatment. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737140.2019.1
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http://dx.doi.org/10.1080/14737140.2019.1538797DOI Listing
January 2019
11 Reads

Pilot of an International Collaboration to Build Capacity to Provide Gynecologic Oncology Surgery in Botswana.

Int J Gynecol Cancer 2018 11;28(9):1807-1811

Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA.

Objectives: Gynecologic malignancies are the leading cause of cancer death among women in Botswana. Twenty-five percent of cervical cancers present at a stage that could be surgically cured; however, there are no gynecologic oncologists to provide radical surgeries. A sustainable model for delivery of advanced surgery is essential to advance treatment for gynecologic malignancies. Read More

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http://dx.doi.org/10.1097/IGC.0000000000001372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221384PMC
November 2018
10 Reads

Cancer of the vulva.

Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:4-13

Division of Obstetrics and Gynecology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Vulvar cancer is an uncommon gynecological malignancy primarily affecting postmenopausal women. There is no specific screening and the most effective strategy to reduce vulvar cancer incidence is the opportune treatment of predisposing and preneoplastic lesions associated with its development. While vulvar cancer may be asymptomatic, most women present with vulvar pruritus or pain, or have noticed a lump or ulcer. Read More

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http://doi.wiley.com/10.1002/ijgo.12609
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http://dx.doi.org/10.1002/ijgo.12609DOI Listing
October 2018
12 Reads

Treatment Outcomes of Patients with Squamous Cell Carcinoma of the Vulva: The Largest Series from a Tertiary Care Hospital.

Obstet Gynecol Int 2018 3;2018:4723167. Epub 2018 Sep 3.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Chiang Mai University, Chiang Mai, Thailand.

Objective: To evaluate the outcomes of squamous cell carcinoma (SCCA) of the vulva treated at our tertiary care center.

Methods: The medical records of SCCA patients treated between January 2006 and December 2015 were retrospectively reviewed.

Results: One hundred forty-five patients met the criteria with the median age of 57 years old, and 58. Read More

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https://www.hindawi.com/journals/ogi/2018/4723167/
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http://dx.doi.org/10.1155/2018/4723167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140126PMC
September 2018
7 Reads

Robot-assisted inguinal sentinel lymph node biopsy in primary yolk sac tumor of the vulva.

Surg Oncol 2018 Sep 8;27(3):520. Epub 2018 Jun 8.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Primary yolk sac tumor (YST) of the vulva is extremely rare and only introduced in case reports [1]. For those, routine inguinal lymph node dissection (LND) in absence of palpable inguinal lymph node is questionable. To avoid complications of inguinal LND, such as lymphedema, inguinal sentinel lymph node biopsy (SLNB) can be considered [2,3]. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09607404173038
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http://dx.doi.org/10.1016/j.suronc.2018.05.035DOI Listing
September 2018
17 Reads

Vulvar cancer recurrence - an analysis of prognostic factors in tumour-free pathological margins patients group.

Ginekol Pol 2018 ;89(8):424-31

University Hospital Brno, Brno, Czech Republic; Masaryk University, Brno, Czech Republic.

Objectives: To evaluate risk factors associated with the local recurrence of invasive squamous cell vulvar cancer in patient group with tumor-free pathological margins.

Material And Methods: This is a retrospective analysis of 47 patients who underwent surgical treatment at University Hospital Brno, the Czech Republic between 2007 and 2014. 24 patients were classified as IB stage and three as II stage. Read More

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http://dx.doi.org/10.5603/GP.a2018.0073DOI Listing
January 2018
5 Reads

Using hospital registries in Australia to extend data availability on vulval cancer treatment and survival.

BMC Cancer 2018 Aug 30;18(1):858. Epub 2018 Aug 30.

Royal Adelaide Hospital, North Terrace, Adelaide, SA, 5000, Australia.

Background: The value of hospital registries for describing treatment and survival outcomes for vulval cancer was investigated. Hospital registry data from four major public hospitals in 1984-2016 were used because population-based data lacked required treatment and outcomes data. Unlike population registries, the hospital registries had recorded FIGO stage, grade and treatment. Read More

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http://dx.doi.org/10.1186/s12885-018-4759-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117879PMC
August 2018
9 Reads

[Analysis of clinical characters of female vulvar Paget disease].

Zhonghua Fu Chan Ke Za Zhi 2018 Aug;53(8):540-546

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the clinical and pathological features, diagnosis and treatment of primary vulvar Paget disease (VPD) , and analyze the related factors that may affect the recurrence. A retrospective study was carried out on 36 patients diagnosed as VPD pathologically from January 1983 to December 2017 at Peking Union Medical College Hospital, Chinese Academy of Medical Sciences. The clinical and pathological features, diagnosis, treatment and prognosis and the factors influencing recurrence rate of VPD were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.08.006DOI Listing
August 2018
13 Reads

Long-term oncological outcomes of patients with negative sentinel lymph node in vulvar cancer. Comparative study with conventional lymphadenectomy.

Acta Obstet Gynecol Scand 2018 Dec 26;97(12):1427-1437. Epub 2018 Aug 26.

Section of Gynecologic Oncology, Clinical Institute of Gynecology, Obstetrics and Neonatology (ICGON), Hospital Clínic, Biomedical Research Institute August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

Introduction: The aim of this study was to compare oncological outcomes and morbidity in patients with early-stage vulvar cancer with negative sentinel lymph node (SLN) biopsy vs negative inguinofemoral lymphadenectomy (IFL).

Material And Methods: Study with retrospectively collected data in patients with squamous cell vulvar carcinomas ≤ 4 cm without suspected inguinofemoral lymph node metastases. Only patients with negative nodes after histopathology procedure were followed. Read More

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http://dx.doi.org/10.1111/aogs.13431DOI Listing
December 2018
15 Reads

En Bloc Resection of an Aggressive Angiomyxoma by a Novel Combination Laparoscopic and Open Perineal Approach.

J Minim Invasive Gynecol 2018 Jul 19. Epub 2018 Jul 19.

Department of Gynecologic Oncology, Cancer Institute Hospital, Tokyo, Japan.

Study Objective: To show a novel combination laparoscopic and open perineal approach to complete resection of aggressive angiomyxoma.

Design: Step-by-step video demonstration of the combination approach (Canadian Task Force classification III).

Setting: Combined laparoscopic and open perineal approach was performed in the tertiary center. Read More

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http://dx.doi.org/10.1016/j.jmig.2018.07.008DOI Listing
July 2018
37 Reads

Prognostic impact of reduced tumor-free margin distance on long-term survival in FIGO stage IB/II vulvar squamous cell carcinoma.

J Gynecol Oncol 2018 Sep 13;29(5):e61. Epub 2018 Apr 13.

Department of Obstetrics and Gynecology, Sant'Anna Hospital, University of Torino, Turin, Italy.

Objective: We aimed to identify the minimum tumor-free margin distance conferring long-term oncological safety in patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IB/II vulvar squamous cell carcinoma (VSCC).

Methods: This was a retrospective cohort study in patients with stage IB/II VSCC treated at a single institution in Turin, Italy. The main aim was to identify the minimum tumor-free margin distance that confers oncological safety in early-stage VSCC. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3802/jgo.2018.29
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http://dx.doi.org/10.3802/jgo.2018.29.e61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078886PMC
September 2018
11 Reads

Pembrolizumab in Recurrent Squamous Cell Carcinoma of the Vulva: Case Report and Review of the Literature.

Gynecol Obstet Invest 2019 17;84(1):94-98. Epub 2018 Jul 17.

Norton Cancer Institute, Norton Healthcare, Louisville, Kentucky, USA.

Advanced vulvar cancer is associated with a very poor prognosis. Surgical resection is the mainstay of treatment, with radiation indicated for areas at high risk for recurrence. When surgical and radiation options have been exhausted, the effectiveness of systemic chemotherapy is poor. Read More

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https://www.karger.com/Article/FullText/491090
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http://dx.doi.org/10.1159/000491090DOI Listing
March 2019
54 Reads

Efficacy and tolerance of photodynamic therapy for vulvar Paget's disease: a multicentric retrospective study.

Eur J Dermatol 2018 Jun;28(3):351-355

Service de Dermatologie, Nantes University Hospital, Nantes, France.

Background: Extra-mammary Paget's disease is a rare form of intraepithelial adenocarcinoma with a variable pattern of invasion, sometimes associated with distant malignancy. Vulvar Paget's disease (VPD) represents 1% of all vulvar cancers. Standard treatment is surgical excision, however, the recurrence rate is high and surgery leads to anatomical, functional, and sexual morbidity. Read More

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http://dx.doi.org/10.1684/ejd.2018.3289DOI Listing
June 2018
4 Reads

Human Papillomavirus Genotypes and HPV16 E6/E7 Variants among Patients with Genital Cancers in Vietnam.

Jpn J Infect Dis 2018 Nov 29;71(6):419-426. Epub 2018 Jun 29.

Department of Viral Infection and International Health, Graduate School of Medical Sciences/Advanced Preventive Medical Sciences, Kanazawa University.

We previously reported human papillomavirus type 52 (HPV52) as the most prevalent high-risk genotype in non-cancer individuals in Vietnam. This study aimed to evaluate HPV genotypes and HPV16 E6 and E7 (E6/E7) gene variations in Vietnamese patients with genital cancers. Biopsy samples were collected from 124 Vietnamese patients with genital cancers (20 with vaginal, 50 with vulvar, and 54 with penile cancer). Read More

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http://dx.doi.org/10.7883/yoken.JJID.2018.206DOI Listing
November 2018
38 Reads

Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget's disease with curative responses.

Cancer Commun (Lond) 2018 06 19;38(1):38. Epub 2018 Jun 19.

Particle Radiation Oncology, Kyoto University Research Reactor Institute, Osaka, 590-0494, Japan.

Background: Although the most commonly recommended treatment for melanoma and extramammary Paget's disease (EMPD) of the genital region is wide surgical excision of the lesion, the procedure is highly invasive and can lead to functional and sexual problems. Alternative treatments have been used for local control when wide local excision was not feasible. Here, we describe four patients with genital malignancies who were treated with boron neutron capture therapy (BNCT). Read More

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http://dx.doi.org/10.1186/s40880-018-0297-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006671PMC
June 2018
24 Reads

Electrochemotherapy pre-treatment in primary squamous vulvar cancer. Our preliminary experience.

J Surg Oncol 2018 Jun 7;117(8):1813-1817. Epub 2018 Jun 7.

Oncologic Gynaecology Unit, Sant'Orsola- Malpighi Hospital, Bologna, Italy.

Background And Objectives: Previous studies showed a local tumor control of 80% in patients with relapsed squamous cell vulvar cancer (V-SCC) treated with electrochemotherapy. These results encouraged electrochemotherapy use as neo-adjuvant treatment in V-SCC. The objective of this study was to evaluate the effectiveness of electrochemotherapy in reducing tumor burden in V-SCC. Read More

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http://dx.doi.org/10.1002/jso.25072DOI Listing
June 2018
8 Reads

Technetium-99m-based Radiopharmaceuticals in Sentinel Lymph Node Biopsy: Gynecologic Oncology Perspective.

Curr Pharm Des 2018 ;24(15):1652-1675

Department of Molecular and Translational Oncology, Maria Sklodowska-Curie Institute - Oncology Center, Roentgena 5, Warszawa, Poland.

Technetium (99mTc)-radiolabeled colloids are popular tracers used to map lymphatic vessels and regional lymph nodes (LNs). The regional LN status is a significant determinant of cancer stage and patient prognosis, and strongly influences treatment. Regional LN dissection has become a part of surgical treatment. Read More

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http://dx.doi.org/10.2174/1381612824666180515122150DOI Listing
January 2018
33 Reads

Robotic video endoscopic inguinal lymphadenectomy (R-VEIL) for vulvar cancer with sentinel node mapping using indocyanine green and near-infrared fluorescence imaging technology.

Gynecol Oncol 2018 07 3;150(1):203-204. Epub 2018 May 3.

Department of Women's and Children's Health, "Agostino Gemelli" Foundation University Hospital, Catholic University, Rome, Italy.

Objectives: Video endoscopy inguinal lymphadenectomy (VEIL) has emerged as the new frontier for the surgical staging of vulvar cancer (VC) [1, 2]. In this surgical film we show a step-by-step video presentation of a Robotic SLNmapping using ICG (Canadian Task Force classification III). Although the therapeutic benefit of SLN remains controversial in clinical N0 (cN0) with VC N 4 cm [3], it provides prognostic information that can guide further adjuvant treatment. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.04.568DOI Listing
July 2018
5 Reads

The best of both worlds: a hybrid approach for optimal pre- and intraoperative identification of sentinel lymph nodes.

Eur J Nucl Med Mol Imaging 2018 10 25;45(11):1915-1925. Epub 2018 Apr 25.

Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Albinusdreef 2 (C2-S zone), PO BOX 9600, 2300 RC, Leiden, The Netherlands.

Purpose: Hybrid image-guided surgery technologies such as combined radio- and fluorescence-guidance are increasingly gaining interest, but their added value still needs to be proven. In order to evaluate if and how fluorescence-guidance can help realize improvements beyond the current state-of-the-art in sentinel node (SN) biopsy procedures, use of the hybrid tracer indocyanine green (ICG)-Tc-nancolloid was evaluated in a large cohort of patients.

Patients And Methods: A prospective trial was conducted (n = 501 procedures) in a heterogeneous cohort of 495 patients with different malignancies (skin malignancies, oral cavity cancer, penile cancer, prostate cancer and vulva cancer). Read More

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http://dx.doi.org/10.1007/s00259-018-4028-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132545PMC
October 2018
9 Reads

Triple flap technique for vulvar reconstruction.

Ann Chir Plast Esthet 2018 Jul 9;63(4):343-348. Epub 2018 Apr 9.

Department of plastic reconstructive and aesthetic surgery, university hospital of Picardie, 80054 Picardie cedex 1, France. Electronic address:

Objective: Perineal defects are encountered ever more frequently, in the treatment of vulvar cancers or abdominoperineal resection. The surgical treatment of vulvar cancer leads to significant skin defect. The aim of the reconstruction is not to provide volume but rather to resurface perineum. Read More

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http://dx.doi.org/10.1016/j.anplas.2018.03.007DOI Listing
July 2018
6 Reads

Survival analysis of patients with invasive extramammary Paget disease: implications of anatomic sites.

BMC Cancer 2018 04 10;18(1):403. Epub 2018 Apr 10.

Department of Urology, Shanghai 9th People's Hospital, Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, People's Republic of China.

Background: Extramammary Paget disease (EMPD) is a rare malignant dermatosis with poorly defined outcomes. We investigated clinical characteristics of invasive EMPD at different anatomic sites and by subject demographics to determine prognostic factors for overall survival (OS).

Methods: All patient data were collected from the Surveillance, Epidemiology, and End Results (SEER) program, 1973-2013, of the U. Read More

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http://dx.doi.org/10.1186/s12885-018-4257-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894213PMC
April 2018
18 Reads

Vulvar syringomas as a part of nonfamilial generalized eruptive form: Unusual lesions leading to pseudohyper-trophy of the labia majora.

Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.

Bakırköy Dr. Sadi Konuk Research & Training Hospital, Dermatology Clinic, İstanbul, Turkey.

We present a case of eruptive generalized syringoma with vulvar involvement. This case is unique in terms of being a nonfamilial, linear variant, leading to pseudohypertrophy of the labia majora. Read More

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March 2018
11 Reads

Carcinome épidermoïde sur lichen scléro-atrophique vulvaire: Epidermoid carcinoma associated with atrophic vulvar lichen sclerosus.

Pan Afr Med J 2018 2;29. Epub 2018 Jan 2.

Service de Dermatologie, Hopital Militaire Mohamed V, Rabat, Maroc.

We here report the case of a 58-year old female patient with no particular past medical history, presenting with a 5-year history of vulvar pruritis, drought and vulvodynia at the Department of Dermatology. Clinical examination showed diffuse porcelaine lesions at the level of the vulva, with a yellowish hemispheric nodular lesion measuring 1 cm in diameter on the whitish plates and some excoriated lesions due to scratching. A skin biopsy was performed at the level of the whitish lesions and at the level of the nodular lesion. Read More

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http://dx.doi.org/10.11604/pamj.2018.29.2.14414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889508PMC
May 2018
3 Reads

Racial and ethnic disparities over time in the treatment and mortality of women with gynecological malignancies.

Gynecol Oncol 2018 04;149(1):4-11

Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

Objective: To examine temporal trends in treatment and survival among black, Asian, Hispanic, and white women diagnosed with endometrial, ovarian, cervical, and vulvar cancer.

Methods: Using the National Cancer Database (2004-2014), we identified women diagnosed with endometrial, ovarian, cervical, and vulvar cancer. For each disease site, we analyzed race/ethnicity-specific trends in receipt of evidence-based practices. Read More

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http://dx.doi.org/10.1016/j.ygyno.2017.12.006DOI Listing
April 2018
5 Reads

Hyperbaric oxygen therapy as adjuvant for treating wound complications after extensive resection for vulvar malignancy.

Undersea Hyperb Med 2018 Jan-Feb;45(1):27-32

Hyperbaric Medicine Department, Instituto Brasileiro de Controle do Câncer, Sao Paulo, Brazil.

Introduction: Necrosis, wound breakdown, and infection represent major complications associated with radical vulvectomy. We aimed to analyze the feasibility of hyperbaric oxygen (HBO₂) therapy as an adjunctive treatment for such complications.

Methods: We performed a retrospective analysis of the medical records, clinical charts, and operative records of vulvar cancer patients who underwent hyperbaric oxygen therapy after extensive surgical resection in our institute between 2012 and 2016, with a comparison of the clinical outcomes of patients with similar surgical procedures andsevere wound complications who did not undergo HBO₂. Read More

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March 2018
18 Reads

Vulvar field resection based on ontogenetic cancer field theory for surgical treatment of vulvar carcinoma: a single-centre, single-group, prospective trial.

Lancet Oncol 2018 04 9;19(4):537-548. Epub 2018 Mar 9.

Department of Gynecology, Women's and Children's Center, University of Leipzig, Leipzig, Germany.

Background: The incidence of vulvar cancer is increasing, but surgical treatment-the current standard of care-often leads to unsatisfactory outcomes, especially in patients with node-positive disease. Preliminary results at our centre showed that locoregional spread of vulvar carcinoma occurs within tissue domains defined by stepwise embryonic and fetal development (ontogenetic cancer fields and associated lymph node regions). We propose that clinical translation of these insights into practice could improve outcomes of surgical treatment of vulvar cancer. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30109-8DOI Listing
April 2018
15 Reads

Endoscopy-assisted inguinal lymphadenectomy in vulvar cancer.

Arch Gynecol Obstet 2018 May 8;297(5):1277-1283. Epub 2018 Mar 8.

Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400011, China.

Objective: To explore the feasibility and efficiency of video endoscopic inguinal lymphadenectomy (VEIL) for vulvar cancer.

Methods: We evaluated 46 patients with vulvar cancer. Treatment included VEIL using the hypogastric subcutaneous approach (VEIL-H, 17 patients), VEIL with the limb subcutaneous surgical approach (VEIL-L, 8 patients), and open inguinal lymphadenectomy (OIL, 21 patients). Read More

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http://link.springer.com/10.1007/s00404-018-4732-6
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http://dx.doi.org/10.1007/s00404-018-4732-6DOI Listing
May 2018
12 Reads

Emerging Molecular Imaging Techniques in Gynecologic Oncology.

PET Clin 2018 Apr 10;13(2):289-299. Epub 2018 Jan 10.

Department of Nuclear Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5 Fu-Shin Street, Kueishan, Taoyuan 333, Taiwan.

Molecular imaging (mainly PET and MR imaging) has played important roles in gynecologic oncology. Emerging MR-based technologies, including DWI, CEST, DCE-MR imaging, MRS, and DNP, as well as FDG-PET and many novel PET radiotracers, will continuously improve practices. In combination with radiomics analysis, a new era of decision making in personalized medicine and precisely guided radiation treatment planning or real-time surgical interventions is being entered into, which will directly impact on patient survival. Read More

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http://dx.doi.org/10.1016/j.cpet.2017.11.011DOI Listing
April 2018
4 Reads

"The Future of Vulvar Disease: New and Ongoing Challenges": Presidential Lecture - XXIV World Congress 2017, Mendoza, Argentina.

J Low Genit Tract Dis 2018 Apr;22(2):166-168

Department of Vulvar Diseases and Vulvovaginal Infections, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

The 21st century brought along a number of discoveries and medical advances. With the advances, we can mention the following: target therapies for cancer, genomics and molecular biology, pharmacogenomics, minimally invasive and robotic surgery, immunosuppressive therapies in transplant patients, human papillomavirus in the era of vaccination, and aesthetic vulvovaginal procedures. All of them have greatly influenced medicine. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000379DOI Listing
April 2018
9 Reads

Primary vulvar Paget disease - the importance of clinical suspicion.

Dermatol Online J 2017 Oct 15;23(10). Epub 2017 Oct 15.

Dermatology Department, Centro Hospitalar do Porto, Portugal.

Extramammary Paget disease of the vulva is a rare condition that accounts for only 1-2% of vulvar malignancies and represents a frequent cause of misdiagnosis. It is most commonly seen in postmenopausal women. Clinically it is similar to Paget disease of the breast, appearing as red, well-demarcated eczematoid lesions, with slightly raised edges. Read More

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October 2017
9 Reads

A vulvar mass as the first presentation in colorectal carcinoma: An unusual site of metastasis masquerading a primary cancer.

Taiwan J Obstet Gynecol 2018 Feb;57(1):157-160

Department of Pathology, MacKay Medical College, MacKay Memorial Hospital, No.45, Minsheng Rd., Tamsui District, 25160, New Taipei City, Taiwan; MacKay Junior College of Medicine, Nursing, and Management, New Taipei City, Taiwan. Electronic address:

Objective: To demonstrate a case with a vulvar metastasis masquerading a primary vulvar malignancy. The clinical and histological features, mechanism, and impact to the prognosis are discussed.

Case Report: A 58-year-old woman presented to gynecologist for abnormal vaginal discharge. Read More

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http://dx.doi.org/10.1016/j.tjog.2017.12.035DOI Listing
February 2018
6 Reads

Human papillomavirus infection and lichen sclerosus: coincidence or link?

Int J Dermatol 2018 05 19;57(5):617-618. Epub 2018 Feb 19.

Dermatology Clinic, University of Catania, Catania, Italy.

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http://dx.doi.org/10.1111/ijd.13933DOI Listing
May 2018
6 Reads

Effect of blue dye guided lymph channel ligation on the surgical morbidity of groin lymphadenectomy for vulval cancer: a feasibility study.

J Obstet Gynaecol 2018 Jul 9;38(5):674-677. Epub 2018 Feb 9.

c Department of Gynaecological Oncology , John Radcliffe Hospital , Oxford , UK.

Inguinal lymphadenectomy has significant morbidity. Blue dye-guided lymph channel ligation is an effective technique for resolving lymphocele. This was a feasibility study in a preventative setting. Read More

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http://dx.doi.org/10.1080/01443615.2017.1392492DOI Listing
July 2018
5 Reads

Haematocolpos caused by a large vulvar dermoid cyst complicating type Ib female circumcision.

J Obstet Gynaecol 2018 May 8;38(4):583-584. Epub 2018 Feb 8.

c Department of Obstetrics & Gynecology , Al-Galaa Teaching Hospital & As-Salam International Hospital , Cairo , Egypt.

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http://dx.doi.org/10.1080/01443615.2017.1380614DOI Listing
May 2018
8 Reads
0.604 Impact Factor

More than Grapes and Bleeding: An Updated Look at Pelvic Rhabdomyosarcoma in Young Women.

J Pediatr Adolesc Gynecol 2018 Oct 5;31(5):522-525. Epub 2018 Feb 5.

Department of Gynecology, The Royal Children's Hospital Melbourne, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Australia.

Study Objective: To review our local experience with urogenital rhabdomyosarcoma (RMS) to determine the most common clinical presentation(s).

Design: Retrospective case series of all female patients with urogenital RMS who presented to a tertiary pediatric hospital between 1996 and 2016. All institutional electronic pathology reports were screened for RMS and those that were pelvic in origin and occurred in female patients were included for further analysis. Read More

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http://dx.doi.org/10.1016/j.jpag.2018.01.006DOI Listing
October 2018
7 Reads

Endoscopic examination of labial fusion in a postmenopausal woman: a case report.

J Med Case Rep 2018 Feb 2;12(1):26. Epub 2018 Feb 2.

Department of Obstetrics and Gynecology, Tohoku University Hospital, 1-1, Seiryo, Aoba, Sendai, Miyagi, 980-8574, Japan.

Background: Labial fusion is defined as adhesions of the labia minora or majora. Labial fusion may cause urinary retention. Surgical treatment based on an accurate anatomic assessment may be needed, but the usefulness of endoscopic examination for this disease has not been reported. Read More

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http://dx.doi.org/10.1186/s13256-018-1568-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796510PMC
February 2018
6 Reads