3,121 results match your criteria Surgical Treatment of Vulvar Cancer


Electrochemotherapy in Vulvar Cancer and Cisplatin Combined with Electroporation. Systematic Review and In Vitro Studies.

Cancers (Basel) 2021 Apr 21;13(9). Epub 2021 Apr 21.

Division of Oncologic Gynecology, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

Electrochemotherapy (ECT) is an emerging treatment for solid tumors and an attractive research field due to its clinical results. This therapy represents an alternative local treatment to the standard ones and is based on the tumor-directed delivery of non-ablative electrical pulses to maximize the action of specific cytotoxic drugs such as cisplatin (CSP) and bleomycin (BLM) and to promote cancer cell death. Nowadays, ECT is mainly recommended as palliative treatment. Read More

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Malignant nodular melanoma of the vulva: a rare and aggressive tumour of the female genital tract (case report).

Pan Afr Med J 2021 3;38:115. Epub 2021 Feb 3.

Department of Obstetrics and Gynaecology, Dr George Mukhari Academic Hospital, Sefako Makgatho Health Sciences University, Pretoria North, Gauteng Province, South Africa.

Malignant melanoma of the vulva is a rare and aggressive tumour with dismal prognosis. It tends to recur and metastasize early. Surgical excision with or without regional lymph node dissection is still the treatment of choice with adjuvant therapy decided on a case by case. Read More

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Vulvar Paget's disease and stromal invasion: Clinico-pathological features and survival outcomes.

Surg Oncol 2021 Apr 16;38:101581. Epub 2021 Apr 16.

Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Torino, Torino, Italy.

Purpose: To evaluate clinico-pathological features, treatments and survival outcomes of vulvar Paget's disease (VPD).

Methods: We retrospectively reviewed VPD diagnosed between 1983 and 2018 at the Department of Surgical Sciences, Sant'Anna Hospital, Turin. Clinico-pathological characteristics and surgical treatment outcomes were investigated according to the depth of invasion. Read More

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Hidradenoma papilliferum of the hymen: a case report.

J Med Case Rep 2021 Apr 13;15(1):162. Epub 2021 Apr 13.

Department of Gynaecology and Obstetrics, Akdeniz University Hospital, Antalya, Turkey.

Background: Hidradenoma papilliferum is a rare benign neoplasm arising from apocrine glands. It occurs commonly on the anogenital region of middle-aged women. It usually presents as a slow growing, solitary asymptomatic, skin colored or red nodule less than 1 cm in diameter. Read More

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The impact of the COVID-19 coronavirus pandemic on the surgical management of gynecological cancers: Analysis of the multicenter database of the French SCGP and the FRANCOGYN group.

J Gynecol Obstet Hum Reprod 2021 Mar 28;50(8):102133. Epub 2021 Mar 28.

Departement of Obstetrics and Gynecology, Angers University Hospital, Angers, France; CESP-INSERM, U1018, Team 7, Reproductive and sexual health, Paris-Sud University, 94276 Villejuif, France. Electronic address:

Introduction: The coronavirus SARS-CoV-2 (COVID-19) pandemic has put tremendous pressure on the French healthcare system. Almost all hospital departments have had to profoundly modify their activity to cope with the crisis. In this context, the surgical management of cancers has been a topic of debate as care strategies were tailored to avoid any delay in treatment that could be detrimental to patient wellbeing while being careful not to overload intensive care units. Read More

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An abdominal-sacral approach with preoperative embolisation for vulvar solitary fibrous tumour: a case report.

World J Surg Oncol 2021 Mar 29;19(1):92. Epub 2021 Mar 29.

Department of Obstetrics and Gynecology, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

Background: Solitary fibrous tumours (SFTs) in the female genital tract are uncommon. Resection of these tumours is controversial because it can cause life-threatening haemorrhage. We report a case of vulvar SFT that was excised in a combined abdominal-sacral approach after preoperative embolisation. Read More

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Vulvar Basal Cell Carcinoma: Clinical and Histopathologic Features.

Int J Gynecol Pathol 2021 Mar 23. Epub 2021 Mar 23.

Department of Pathology, Centre Hospitalier Intercommunal de Créteil, Créteil, France (R.F., M.A.B., N.T., X.S.-G.) National Health Institute of Tunisia, Tunis, Tunisia (S.R.).

Basal cell carcinoma (BCC) is the most frequent skin cancer but <1% of the cases develop in the vulva. Histoprognostic features of vulvar BCCs are not recognized and, consequently, the treatment of the disease is not well codified. To overcome this lack of knowledge, we have performed a retrospective analysis of vulvar BBCs to assess the value of various histological features regarding the disease outcome. Read More

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Survey of the clinical practice pattern of using sentinel lymph node biopsy in patients with gynecological cancers in Japan: the Japan Society of Gynecologic Oncology study.

Int J Clin Oncol 2021 May 25;26(5):971-979. Epub 2021 Mar 25.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

Background: Sentinel lymph node (SN) biopsy is essential for evaluating survival and minimal treatment-related morbidity associated with cervical, endometrial, and vulvar cancer in Japan. As such, our aim in this study was to evaluate the current practice pattern of using SN biopsy for cervical, endometrial, and vulvar cancer in Japan.

Methods: We deployed a 47-question survey on the use of SN biopsy for gynecological cancers to 216 gynecological oncology training facilities. Read More

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Patterns of recurrence and survival in vulvar cancer: A nationwide population-based study.

Gynecol Oncol 2021 Mar 15. Epub 2021 Mar 15.

Dept of Hereditary Cancer, Karolinska University Hospital, Dept of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.

Objective: To examine the patterns of recurrence and how these patterns are associated with survival in vulvar squamous cell carcinoma. We also explored the survival impact of surgical groin staging (SGS).

Methods: Nationwide population-based study including women diagnosed with vulvar squamous cell carcinoma between 2012 and 2015 and registered in the Swedish Quality Registry for Gynecologic Cancer. Read More

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A rare case of nevus sebaceous of the bilateral labia minora: A case report and review of literature.

Medicine (Baltimore) 2021 Mar;100(10):e25047

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital.

Rationale: Nevus sebaceous (NS) is a lesion caused by congenital hyperplastic disorder of the sebaceous glands. It commonly noted in the scalp and face and rarely in the trunk, neck, or oral mucosa. We present a rare case of a lesion arising in the genital region. Read More

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Retrospective analysis of surgically treated cases of squamous cell carcinoma vulva.

J Cancer Res Ther 2021 Jan-Mar;17(1):186-190

Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.

Context: Vulvar carcinoma accounts for 3%-5% of gynecologic malignancies. The past three decades has observed changes in the trends of clinical characteristics and treatment modalities used in managing this disease.

Aims: The aim of the present study is to analyze the clinic-pathological characteristics and survival of women with squamous cell carcinoma vulva who underwent primary surgical management. Read More

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Safety and feasibility of single-incision radical vulvectomy: a novel approach for the treatment of vulvar cancer.

Ann Transl Med 2021 Feb;9(4):320

Department of Gynecology, Obstetrics and Gynecology Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Background: In the process of decreasing the morbidity of wound-related complications after vulvectomy and IL for treating vulvar malignancy, we performed a novel surgical procedure-single-incision radical vulvectomy (SIRV). Here, we share our initial experience and report its safety and feasibility.

Methods: Patients with advanced local vulvar tumors were sequentially enrolled in this prospective cohort study to undergo SIRV. Read More

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February 2021

Pelvic exenteration for colorectal and non-colorectal cancer: a comparison of perioperative and oncological outcome.

Int J Colorectal Dis 2021 Mar 7. Epub 2021 Mar 7.

Department of Visceral, Thoracic and Vascular Surgery, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.

Background: Pelvic exenteration (PE) is the only option for long-term cure of advanced cancer originating from different types of tumor or recurrent disease in the lower pelvis. The aim was to show differences between colorectal and non-colorectal cancer in survival and postoperative morbidity.

Methods: Retrospective data of 63 patients treated with total pelvic exenteration between 2013 and 2018 are reported. Read More

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A prospective study of the adaptive changes in the gut microbiome during standard-of-care chemoradiotherapy for gynecologic cancers.

PLoS One 2021 4;16(3):e0247905. Epub 2021 Mar 4.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.

Background: A diverse and abundant gut microbiome can improve cancer patients' treatment response; however, the effect of pelvic chemoradiotherapy (CRT) on gut diversity and composition is unclear. The purpose of this prospective study was to identify changes in the diversity and composition of the gut microbiome during and after pelvic CRT.

Materials And Methods: Rectal swabs from 58 women with cervical, vaginal, or vulvar cancer from two institutions were prospectively analyzed before CRT (baseline), during CRT (weeks 1, 3, and 5), and at first follow-up (week 12) using 16Sv4 rRNA gene sequencing of the V4 hypervariable region of the bacterial 16S rRNA marker gene. Read More

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Age, treatment and prognosis of patients with squamous cell vulvar cancer (VSCC) - analysis of the AGO-CaRE-1 study.

Gynecol Oncol 2021 May 26;161(2):442-448. Epub 2021 Feb 26.

Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

Background: Despite an increasing incidence with simultaneous decreasing age of onset, vulvar squamous cell carcinoma (VSCC) is still a disease that mainly effects the elderly population. Data on the association of age with prognosis and treatment patterns in VSCC are sparse.

Methods: This is an analysis of the AGO-CaRE-1 cohort. Read More

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A strengthening the reporting of observational studies in epidemiology (STROBE): Are HE4 and CA 125 suitable to detect a Paget disease of the vulva?

Medicine (Baltimore) 2021 Feb;100(5):e24485

Clinical Patology Laboratory, IRCCS Istituto Tumori "Giovanni Paolo II".

Abstract: Paget disease is a complex disorder that can be identified in the breast (mammary Paget disease) or in other locations (extramammary Paget's disease) such as ano-genital skin (Paget disease of the vulva -PVD). This condition is associated with low mortality, but a late diagnosis and recurrence can negatively impact the prognosis. Therefore, the main objective of this study is to evaluate if the human epididymis protein 4 (HE4) and cancer antigen125 (CA125) can promote recognition of PVD in early stages and during the relapses. Read More

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February 2021

Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial.

Sci Rep 2021 02 11;11(1):3667. Epub 2021 Feb 11.

Division of Cancer Medicine, Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Blvd, FC8.2026, Houston, TX, 77030, USA.

Vaginal and vulvar squamous cell carcinoma (SCC) are rare tumors that can be challenging to treat in the recurrent or metastatic setting. We present a case series of patients with vaginal or vulvar SCC who were treated with single-agent pembrolizumab as part of a phase II basket clinical trial to evaluate efficacy and safety. Two cases of recurrent and metastatic vaginal SCC, with multiple prior lines of systemic chemotherapy and radiation, received pembrolizumab. Read More

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February 2021

Neoadjuvant imatinib as treatment preceding surgery for vulvar dermatofibrosarcoma protuberans.

Dermatol Ther 2021 Mar 20;34(2):e14860. Epub 2021 Feb 20.

Di.S.Sal. Section of Dermatology, University of Genoa, San Martino Polyclinic Hospital IRCCS, Genoa, Italy.

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Lower Genital Tract Melanomas: Staging, Predictors of Outcome, and New Therapeutic Options.

Anticancer Res 2021 Feb;41(2):999-1004

Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany.

Background/aim: Identification of predictors of survival of patients with lower genital tract melanoma (LGTM) and evaluation of the effectiveness of immunotherapy.

Patients And Methods: Data of twenty women with LGTM were retrospectively collected. Survival outcomes were evaluated using the Kaplan-Meier method. Read More

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February 2021

Surgical Treatment of Vulvar HSIL: Adjuvant HPV Vaccine Reduces Recurrent Disease.

Vaccines (Basel) 2021 Jan 25;9(2). Epub 2021 Jan 25.

Department of Gynecology and Obstetrics, Comprehensive Cancer Center, Medical University of Vienna, Austria Währinger Gürtel 18-20, 1090 Vienna, Austria.

Data suggest that adjuvant human papillomavirus (HPV)-vaccination in women treated for cervical HPV diseases reduces recurrent disease. This study investigates adjuvant HPV-vaccination and the rate of recurrence in women undergoing surgery for vulvar high-grade squamous intraepithelial lesions (HSIL). From January 2013 to April 2020, we enrolled 149 women in a prospective case-control study. Read More

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January 2021

[Value of high-resolution anoscopy in the diagnosis of anal precancerous lesions].

Zhonghua Fu Chan Ke Za Zhi 2021 Jan;56(1):34-42

Center for Diagnosis and Treatment of Cervical Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.

To evaluate the value of high-resolution anoscopy (HRA) in the diagnosis of anal precancerous lesions. A retrospective cohort study was performed, which included 142 patients who underwent HRA in vulvar and anal clinic at Obstetrics and Gynecology Hospital of Fudan University from January 2014 to December 2019. With the perianal and anal canal biopsy pathology as the "gold standard", the diagnostic value of HRA and specific findings for anal precancerous lesions were evaluated and the clinical characteristics of patients with anal precancerous lesions were analyzed. Read More

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January 2021

Robot-Assisted Radical Cystectomy for Pediatric Bladder Rhabdomyosarcoma.

J Endourol Case Rep 2020 29;6(4):461-464. Epub 2020 Dec 29.

Department of Pediatric Urology and Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

The standard treatments for muscle-invasive bladder cancer with no metastasis are total cystectomy and urinary diversion. Although robot-assisted radical cystectomy (RARC) was covered from April 2018 by the Japanese National Health Insurance system, and the number of RARC is increasing, there has been no pediatric case report on RARC in Japan. We report the case of a 6-year-old Japanese girl who was referred to our hospital with the chief complaint of a vulvar tumor protrusion during defecation. Read More

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December 2020

Bartholin gland carcinoma in a young female: a rare disease in an unusual age group.

BMJ Case Rep 2021 Jan 11;14(1). Epub 2021 Jan 11.

Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.

Primary Bartholin gland carcinoma (BGC) is an extremely rare disease. It typically presents in elderly women. It can be confused with Bartholin gland cyst, which is a benign condition leading to a delay in diagnosis and treatment. Read More

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January 2021

Multidisciplinary management of patients with pubic osteomyelitis, a rare but serious complication after surgery and radiation therapy for advanced gynaecological cancer.

BMJ Case Rep 2021 Jan 11;14(1). Epub 2021 Jan 11.

Amsterdam UMC, Amsterdam, The Netherlands

Pubic osteomyelitis is a rare and often late-onset complication of radiation therapy and surgery for vulvar and vaginal carcinoma. It typically presents with vulvar pain, fever, vaginal discharge and/or gait disorders. Pubic osteomyelitis is often accompanied by fistulas or wound dehiscence in the pelvic area. Read More

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January 2021

Giant fibroepithelial vulvar polyp in a pregnant woman.

BMJ Case Rep 2021 Jan 11;14(1). Epub 2021 Jan 11.

Plastic and Reconstructive Surgery Department, Hospital de Egas Moniz, Lisboa, Lisboa, Portugal.

Fibroepithelial polyps are benign lesions that may appear in the vulvovaginal region. They usually occur in women of reproductive age and tend to grow up to 5 cm, but there are some rare cases in which they grow up to 20 cm. We report a case of a 22-year-old woman in the third trimester of her first pregnancy with spontaneous bleeding from a pedunculated mass measuring 15 cm in the widest diameter on the right side of the vulva. Read More

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January 2021

Cancer-related cognitive impairment (CRCI), depression and quality of life in gynecological cancer patients: a prospective study.

Arch Gynecol Obstet 2021 Jun 6;303(6):1581-1588. Epub 2021 Jan 6.

Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples, Via Sergio Pansini n° 5, 80131, Naples, Italy.

Purpose: Cancer-related cognitive impairment (CRCI) has been reported in non-central nervous system neoplasms survivors. The purpose of this study was to evaluate the perception of cognitive decrement in patients undergoing surgical and / or medical therapy for gynecological cancers.

Methods: All women diagnosed with primary gynecological cancer and undergoing active medical treatment have been enrolled in a prospective study. Read More

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The short-term efficacy and safety of fractional CO2 laser therapy for vulvovaginal symptoms in menopause, breast cancer, and lichen sclerosus.

Menopause 2021 01 4;28(5):511-516. Epub 2021 Jan 4.

Prohealth Women's Services, Division of Urogynecology, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Waukesha, WI.

Objective: To review the short-term effects and safety of vulvovaginal fractional microablative CO2 laser therapy on atrophy symptoms using validated questionnaires pre- and posttreatment.

Methods: This is a retrospective chart review from January, 2016 to December, 2019 on 139 women with vulvovaginal atrophy symptoms, who completed three treatments about 6 weeks apart. All were >18 years old and nonpregnant. Read More

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January 2021

Long-term outcomes of individualized management after sentinel lymph-node biopsy for vulvar cancer.

Int J Clin Oncol 2021 Apr 1;26(4):784-793. Epub 2021 Jan 1.

Department of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 East Dongfeng Road, Guangzhou, China.

Background: The management for patients with vulvar cancer after sentinel lymph-node biopsy (SLNB) remains controversial. The aim of this study was to investigate the long-term outcomes of individualized management after SLNB for early stage vulvar cancer.

Methods: The medical records of patients with vulvar cancer treated by surgery involving SLNB between 2004 and 2019 were retrospectively reviewed. Read More

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Surgical margin status and recurrence pattern in invasive vulvar Paget's disease: A Japanese Gynecologic Oncology Group study.

Gynecol Oncol 2021 Mar 29;160(3):748-754. Epub 2020 Dec 29.

Department of Obstetrics and Gynecology, Niigata University School of Medicine, Niigata, Niigata, Japan.

Objective: To examine the association between surgical margin status and recurrence pattern in invasive vulvar Paget's disease.

Methods: This is a preplanned secondary analysis of a previously organized nationwide retrospective study in Japan (JGOG-1075S). Women with stage I-IV invasive vulvar Paget's disease who received surgical treatment from 2001-2010 were examined (n=139). Read More

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