20,094 results match your criteria Surgical Treatment of Vaginal Cancer


Factors associated with counseling and postoperative hormone therapy use in surgically menopausal women.

Menopause 2020 May 11. Epub 2020 May 11.

Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin, Madison WI.

Objective: To determine the rates of and factors associated with preoperative counseling about menopausal symptoms and use of hormone therapy postoperatively in surgically menopausal women.

Methods: This retrospective chart review included patients who underwent bilateral oophorectomies before age 52 at an academic institution during a 3-year period. We used descriptive analyses to characterize the sample and logistic regression to identify factors associated with preoperative counseling about and postoperative systemic hormone therapy for menopausal symptoms. Read More

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http://dx.doi.org/10.1097/GME.0000000000001560DOI Listing

Using a pessary during radiotherapy in reducible pelvic organ prolapse and vaginal cancer: a case report and review of the literature.

J Contemp Brachytherapy 2020 Apr 11;12(2):175-180. Epub 2020 Feb 11.

Department of Radiation Oncology, Hacettepe University Medical School, Ankara, Turkey.

Purpose: Primary vaginal cancer and pelvic organ prolapse (POP) combination is extremely rare. Although definitive chemoradiotherapy (CRT) and brachytherapy (BT) is the standard treatment for advanced stage primary vaginal cancer, there is a limited data about the treatment of primary vaginal cancer combined with POP due to its rarity. In addition, radiotherapy (RT) process may be difficult in these cases and often result in more toxicity. Read More

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http://dx.doi.org/10.5114/jcb.2020.92997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207234PMC

Creatsas modified vaginoplasty as reconstructive treatment of vaginal stenosis due to vaginal or pelvic radiotherapy.

Int J Gynecol Cancer 2020 May 5. Epub 2020 May 5.

Department of Gynecology Oncology, La Fe University and Polytechnic Hospital, Valencia, Spain.

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http://dx.doi.org/10.1136/ijgc-2020-001310DOI Listing

Patient-initiated follow-up after treatment for low risk endometrial cancer: a prospective audit of outcomes and cost benefits.

Int J Gynecol Cancer 2020 May 5. Epub 2020 May 5.

Gynaecological Oncology, Somerset NHS Foundation Trust, Taunton, TA1 5DA, United Kingdom

Objective: Recurrence of low-risk endometrioid endometrial cancer is rare, and traditional hospital follow-up has a cost to both the patient and the healthcare system, without evidence of benefit. We examined the uptake of patient-initiated follow-up, pattern of recurrences, and survival for women following surgical treatment of low-risk endometrial cancer and compared estimated costs with hospital follow-up.

Methods: This study was a prospective audit of outcomes following implementation of a patient-initiated follow-up policy in a UK-based gynecological cancer center for women with low-risk endometrial cancer treated surgically (International Federation of Gynecology and Obstetrics (FIGO) stage 1A, G1-2) from January 2010 to December 2015. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001263DOI Listing

Office hysteroscopy in the management of women with postmenopausal bleeding.

Climacteric 2020 May 5:1-7. Epub 2020 May 5.

Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.

Postmenopausal bleeding (PMB) is a relevant aspect for health-care providers in clinical practice: the first objective is to rule out potential gynecological cancer. The purpose of this narrative review is to evaluate the role of office hysteroscopy in the management of PMB. Office hysteroscopy is a minimally invasive procedure allowing direct visualization of uterine pathology without the need for general anesthesia and the use of an operating room, generating cost savings and greater compliance among patients. Read More

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http://dx.doi.org/10.1080/13697137.2020.1754389DOI Listing

Multi-institutional validation of the ESMO-ESGO-ESTRO consensus conference risk grouping in Turkish endometrial cancer patients treated with comprehensive surgical staging.

J Obstet Gynaecol 2020 Apr 29:1-7. Epub 2020 Apr 29.

Department of Radiation Oncology, Hacettepe University Medical School, Ankara, Turkey.

In this study, 683 patients with endometrial cancer (EC) after comprehensive surgical staging were classified into four risk groups as low (LR), intermediate (IR), high-intermediate (HIR) and high-risk (HR), according to the recent consensus risk grouping. Patients with disease confined to the uterus, ≥50% myometrial invasion (MI) and/or grade 3 histology were treated with vaginal brachytherapy (VBT). Patients with stage II disease, positive/close surgical margins or extra-uterine extension were treated with external beam radiotherapy (EBRT)±VBT. Read More

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http://dx.doi.org/10.1080/01443615.2020.1737661DOI Listing

Laparoscopic laterally extended endopelvic resection procedure for gynecological malignancies.

Int J Gynecol Cancer 2020 Apr 23. Epub 2020 Apr 23.

Department of Gynecologic Oncology, University of Palermo, Palermo, Sicilia, Italy.

Objectives: Pelvic side wall infiltration by gynecological malignancies has been considered for a long time an absolute contraindication to curative resection. The development of the laterally extended endopelvic resection (LEER) has challenged this surgical paradigm. Although the LEER has been standardized in open surgery, only small studies have been published about its endoscopic feasibility. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001129DOI Listing

Laparoscopic vs percutaneous hysterectomy in obese patients: a prospective evaluation.

Facts Views Vis Obgyn 2020 Mar 27;11(4):307-313. Epub 2020 Mar 27.

Division of Gynecologic Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background: Treatment of obese female patients represents a real challenge. Indeed, obesity among women has reached epidemic levels not only elevating the cardiovascular and endocrinological risks, but also increasing the incidence of various gynecological pathologies (e.g. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162661PMC

[Application of MRI in the diagnosis of cervical cancer].

Zhonghua Yi Xue Za Zhi 2020 Apr;100(14):1081-1083

Department of Obstetrics and Gynecology, Jilin University Second Hospital, Changchun 130041, China.

Investigating the diagnostic value of MRI for cervical cancer, including preoperative staging, vagina involvement and lymph node metastasis is the aim of this pape. Select 116 patients with UCC of the second hospital of JiLin University from October 2016 to April 2019. All patients accept MRI examination. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191203-02633DOI Listing

Impact of sentinel lymph node frozen section evaluation to avoid combined treatment in early-stage cervical cancer.

Int J Gynecol Cancer 2020 Apr 9. Epub 2020 Apr 9.

Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

Background: The need for radical surgery followed by adjuvant chemoradiation may be reduced by abandoning radical surgery in patients in whom lymph node involvement is detected intra-operatively.

Objectives: To analyze, in a retrospective cohort study, the efficacy of the algorithm using intra-operative pathological assessment of sentinel lymph nodes.

Methods: A retrospective single-institution study was carried out, which analyzed data from all consecutive patients with cervical cancer who were referred for primary surgical treatment between May 2005 and December 2015. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001113DOI Listing

Expert consensus from the Italian Society for Colposcopy and Cervico-Vaginal Pathology (SICPCV) for colposcopy and outpatient surgery of the lower genital tract during the COVID-19 pandemic.

Int J Gynaecol Obstet 2020 Jun 22;149(3):269-272. Epub 2020 Apr 22.

Department of Obstetrics and Gynecology, Asti Community Hospital, Asti, Italy.

In the context of the COVID-19 pandemic, patients need to be evaluated within 2-4 weeks in the following cases: cytology result of "squamous cell carcinoma," "atypical glandular cells, favor neoplastic," "endocervical adenocarcinoma in situ," or "adenocarcinoma"; histopathological diagnosis of suspected invasion from cervical/vaginal biopsy, or invasive disease after a cervical excision procedure, vaginal excision, or vulvar biopsy/excision; sudden onset of strongly suggestive symptoms for malignancy. Digital imaging technologies represent an important opportunity during the COVID-19 pandemic to share colposcopic images with reference centers, with the aim of avoiding any concentration of patients. All patients must undergo screening for COVID-19 exposure and should wear a surgical mask. Read More

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http://dx.doi.org/10.1002/ijgo.13158DOI Listing

Surgical outcomes of early-stage primary vaginal nonsquamous cell carcinoma.

Int J Clin Oncol 2020 Mar 27. Epub 2020 Mar 27.

Department of Gynecology, Cancer Institute Hospital, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Objective: Definitive radiation therapy (RT), using external beam RT and/or brachytherapy, is a standard treatment option for primary vaginal carcinoma. However, this treatment has poor prognosis when applied to vaginal nonsquamous cell carcinoma (non-SCC). We aimed to clarify treatment outcome and surgical safety in early-stage primary vaginal non-SCC. Read More

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http://dx.doi.org/10.1007/s10147-020-01663-4DOI Listing

Presence of tumor cells in the vagina during surgical treatment could be the source of vaginal recurrence in patients with endometrial carcinoma - A pilot prospective study.

Ann Diagn Pathol 2020 Mar 13;46:151503. Epub 2020 Mar 13.

Department of Pathology, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

Background: The commonest site of recurrence in endometrial cancer (EC) is the vagina, with a rate of 16%. The aim of this study was to determine if vaginal recurrences in EC patients could develop due to contamination of the vagina with glandular tumor cells dropping off on polypoid, large size EC or tumors involving the endocervix, through manipulation of the uterus during surgery.

Methods: This pilot prospective study included 10 consecutive patients with EC, surgically treated with hysterectomy and additional lymphadenectomy according to stage. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151503DOI Listing

The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review.

J Contemp Brachytherapy 2020 Feb 28;12(1):61-66. Epub 2020 Feb 28.

Department of Medicine and Surgery and Translational Medicine, Radiotherapy Oncology, Sant' Andrea Hospital, "Sapienza" University, Rome, Italy.

Purpose: Serous adenocarcinoma (uterine serous carcinoma - USC) is a rare and aggressive histologic subtype of endometrial cancer, with a high-rate of recurrence and poor prognosis. The adjuvant treatment for stage I patients is unclear. The purpose of this study was to evaluate the outcomes of stage I USC treated exclusively with chemotherapy plus vaginal brachytherapy (VBT). Read More

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http://dx.doi.org/10.5114/jcb.2020.92698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073340PMC
February 2020

[A Case of Rectovaginal Fistula after Rectal Cancer Surgery Cured with Estriol Vaginal Tablet and Vaginal Lavage].

Gan To Kagaku Ryoho 2019 Dec;46(13):2078-2080

Dept. of Gastrointestinal Tract Surgery, Fukushima Medical University.

Although rectovaginal fistula is a rare complication of rectal cancer surgery, it is usually difficult to cure with conservative treatment, and patients generally need surgical intervention. A woman in her 70s underwent laparoscopic low anterior resection with right lateral lymph node dissection for rectal cancer. On postoperative day(POD)6, she had an anastomotic leakage and received conservative treatment. Read More

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December 2019

[EPIDERMOID CARCINOMA IN THE NEOVAGINA OF A PATIENT WITH MAYER-ROKITANSKY-KÜSTER-HAUSER SYNDROME. CASE REPORT AND LITERATURE REVIEW].

Rev Colomb Obstet Ginecol 2019 12;70(4):266-276

Unidad de Gestión Clínica de Obstetricia y Ginecología del Hospital Universitario Virgen Macarena de Sevilla (España).

Objective: To present the case of a squamous carcinoma in the neovagina of a patient with Mayer-Rokitansky-Küster-Hauser syndrome and review of the literature related to treatment and prognosis of vaginal neoplasms or HPV infection in transgender women or with MRKH syndrome.

Methods: A 56-year-old woman consulted to the Hospital Universitario of Sevilla (Spain). During the clinical examination, a exophytic tumor at the bottom of the vagina was found and the biopsy reported squamous carcinoma and positive nucleic acid amplification test for human papilloma (HPV) type 16. Read More

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http://dx.doi.org/10.18597/rcog.3328DOI Listing
December 2019

Report from the 21st meeting of the European Society of Gynaecological Oncology (ESGO 2019).

Int J Gynecol Cancer 2020 Apr 5;30(4):441-447. Epub 2020 Mar 5.

Gynaecologic Oncology, Holycross Cancer Centre, Kielce, Poland.

This is a report from the 21st Meeting of the European Society of Gynaecological Oncology (ESGO 2019) held in Athens, Greece, November 2-5, 2019. The conference offered state of the art educational sessions, and oral and poster abstract presentations. The general sessions throughout the meeting focused not only on prevention, screening, diagnosis, treatment, and translational research but also on emerging trends. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001226DOI Listing
April 2020
1.949 Impact Factor

The Use of Both Therapeutic and Prophylactic Vaccines in the Therapy of Papillomavirus Disease.

Front Immunol 2020 18;11:188. Epub 2020 Feb 18.

Department of Biology and Biotechnology "C. Darwin," Sapienza University, Rome, Italy.

Human papillomavirus (HPV) is the most common sexually transmitted virus. The high-risk HPV types (i.e. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040023PMC
February 2020

Detection of HPV mRNA in Self-collected Vaginal Samples Among Urban Ethiopian Women.

Anticancer Res 2020 Mar;40(3):1513-1517

Department of Obstetrics & Gynecology, Skåne University Hospital, Lund University, Lund, Sweden.

Background/aim: Cervical cancer is the most common cancer among women in Ethiopia. The objective was to evaluate the participation rate of a free of charge vaginal self-sample (Aptima multitest swab, Hologic) for the detection of human papillomavirus (HPV) in an Ethiopian cohort.

Patients And Methods: Specimens were collected from women employed by Ethiopian Airlines in Addis Abeba (N=5950). Read More

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http://dx.doi.org/10.21873/anticanres.14096DOI Listing

Surgical treatment of complete uterovaginal prolapse and concomitant vaginal cancer: a video case report.

Int Urogynecol J 2020 Mar 3. Epub 2020 Mar 3.

ASST Monza, Ospedale San Gerardo, Monza, Italy.

Introduction And Hypothesis: The concurrence of vaginal cancer with irreducible uterine prolapse is rare. Reports about the management of vaginal cancer and concomitant irreducible prolapse are scanty in the literature, and there is no consensus on optimal treatment. In this video case report, we show surgical management of vaginal cancer and concomitant stage IV uterovaginal prolapse. Read More

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http://dx.doi.org/10.1007/s00192-020-04263-yDOI Listing

Clinical experience of pelvic radiotherapy or chemoradiotherapy for postoperative uterine cervical cancer using intensity-modulated radiation therapy.

J Radiat Res 2020 May;61(3):470-478

Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan.

The purpose of this study was to reveal treatment outcomes and toxicity after pelvic intensity-modulated radiotherapy (IMRT) for postoperative uterine cervical cancer of Japanese patients. Consecutive patients who were treated with pelvic IMRT for postoperative cervical cancer in our institute were retrospectively analyzed. Relapse-free survival (RFS) and overall survival (OS) were calculated using the Kaplan-Meier estimator, and log-rank tests were used to compare differences. Read More

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http://dx.doi.org/10.1093/jrr/rraa004DOI Listing

Impact of time to radiation therapy in adjuvant settings in endometrial carcinoma: A multicentric retrospective study.

Eur J Obstet Gynecol Reprod Biol 2020 Apr 12;247:121-126. Epub 2020 Feb 12.

Department of Medical Oncology, Institut du Cancer de Montpellier, 34000 Montpellier, France.

Objective: Time to adjuvant treatment could have an impact on cancer prognosis. It is possible that robotic surgery lengthens the healing time of vaginal cuff after minimally invasive hysterectomy. The objective of this study was to state the impact of time to RT (TTR) on prognosis in endometrial carcinoma (EC) patients and to assess variables associated with TTR. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.02.011DOI Listing

Evolution and outcomes of sentinel lymph node mapping in vulvar cancer.

Int J Gynecol Cancer 2020 Mar 18;30(3):383-386. Epub 2020 Feb 18.

Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York City, New York, USA.

Objectives: To characterize our institutional experience with sentinel lymph node (SLN) biopsy in patients with vulvar cancer. We describe the oncologic outcomes of these patients and the utilization of SLN detection techniques over time.

Methods: A retrospective analysis of all patients who underwent inguinofemoral SLN biopsy as part of their treatment for vulvar cancer at Memorial Sloan Kettering Cancer Center from January 1, 2000 to April 1, 2019. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000936DOI Listing

Ultrasonography and robotic-assisted laparoscopic sacrocervicopexy with pubocervical fascia reconstruction: comparison with standard technique.

J Robot Surg 2020 Feb 15. Epub 2020 Feb 15.

Division of Urology and Gynecology, Department of Surgery, Sebastian River Medical Center, Sebastian, FL, USA.

The objective of this study was to evaluate our technique of ultrasonography and robotic-assisted sacrocervicopexy with pubocervical fascia reconstruction (u-RALS-PFR) versus standard robotic-assisted laparoscopic sacrocervicopexy (s-RALS) in the treatment of patients with symptomatic apical/anterior vaginal prolapse. A retrospective analysis was done using the data in two community hospitals. Thirty women presented with symptomatic vaginal apical prolapse and desired minimally invasive surgery (video): (a) standard robotic-assisted laparoscopic sacrocervicopexy (s-RALS) (n = 15) or (b) ultrasound and robotic-assisted sacrocervicopexy with pubocervical fascia reconstruction (u-RALS-PFR) (n = 15) were eligible to participate. Read More

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http://dx.doi.org/10.1007/s11701-020-01051-0DOI Listing
February 2020

Cervical cancer screening coverage, management of squamous intraepithelial lesions and related costs in France.

PLoS One 2020 13;15(2):e0228660. Epub 2020 Feb 13.

stève consultants, Oullins, France.

Until 2018, cervical cancer screening in France was an unorganized individual screening, with the exception of some pilot programs in some territories. We aimed to assess, before the implementation of organized cervical cancer screening and human papillomavirus (HPV) nonavalent vaccine introduction in the vaccination schedule in 2018, (i) the individual cervical cancer screening coverage, (ii) the management of squamous intraepithelial lesions (SIL) and (iii) the related costs. We used the Système National des Données de Santé (SNDS) (Echantillon Généraliste de Bénéficiaires [EGB] and Programme de Médicalisation des systèmes d'information [PMSI]) to assess the cervical screening coverage rate in France between January 1st, 2012 and December 31st, 2014, and to describe diagnostic investigations and therapeutic management of SIL in 2013. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228660PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018036PMC
May 2020
3.234 Impact Factor

Cutaneous paraneoplastic pemphigus syndrome associated with undifferentiated uterine sarcoma.

Gynecol Oncol Rep 2020 May 18;32:100534. Epub 2020 Jan 18.

University of Virginia Health System, 1215 Lee St, Charlottesville, VA 22903, United States.

Pemphigus is a group of autoimmune intraepidermal blistering diseases caused by immunoglobulins directed against keratinocyte cell surface components. In this case report, we identify a non-classical paraneoplastic pemphigus (PNP) foliaceous related to an undifferentiated uterine sarcoma. The patient is a 54-year-old Chinese female with a past medical history of arthritis who presented with worsening fatigue in November 2017 and an itchy, blistering, erythematous annular plaque that first appeared on her chest in February 2018. Read More

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http://dx.doi.org/10.1016/j.gore.2019.100534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000789PMC

Preservation of the mesureter to reduce urinary complications: analysis of data from the observational Leipzig School MMR study.

BJOG 2020 Jun 2;127(7):859-865. Epub 2020 Mar 2.

Department of Gynaecology, University Hospital Leipzig, Leipzig, Germany.

Objective: To evaluate the feasibility and effect of mesureteral preservation on urinary complications in the context of total mesometrial resection (TMMR), a surgical treatment for cervical cancer.

Design: Retrospective cohort study with historic control.

Setting: Single tertiary academic centre. Read More

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http://dx.doi.org/10.1111/1471-0528.16167DOI Listing

Fertility-preserving local excision under a hysteroscope with combined chemotherapy in a 6-year-old child with clear cell adenocarcinoma of the cervix: A case report and review of the literature.

Medicine (Baltimore) 2020 Jan;99(5):e18646

Department of Gynecology, First Affiliated Hospital of Zhengzhou University, Henan.

Introduction: Clear cell adenocarcinoma of the cervix (CCAC), a rare and more severe type of gynecological cancer, is especially rare in pediatric patients. Traditionally, surgery following chemotherapy (CT) and radiation therapy is the preferred treatment for CCAC; however, patients have poor 5-year survival rates than other types of cervical cancers.

Patient Concerns: A 6-year-old girl with a history of vaginal discharge for 18 months was diagnosed with CCAC by histological examination. Read More

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http://dx.doi.org/10.1097/MD.0000000000018646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004716PMC
January 2020

Hormone replacement therapy after surgery for epithelial ovarian cancer.

Cochrane Database Syst Rev 2020 Jan 28;1:CD012559. Epub 2020 Jan 28.

The Christie NHS Foundation Trust, Gynaecological Oncology, Manchester, UK.

Background: Women who have undergone surgical treatment for epithelial ovarian cancer (EOC) may develop menopausal symptoms due to immediate loss of ovarian function following surgery and chemotherapy. Women may experience vasomotor symptoms, sleep disturbance, difficulty concentrating, sexual dysfunction, vaginal symptoms and accelerated osteoporosis. Although hormone replacement therapy (HRT) is the most effective treatment to relieve these symptoms, its safety has been questioned for women with EOC. Read More

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http://dx.doi.org/10.1002/14651858.CD012559.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027384PMC
January 2020

From hysteroscopy to laparoendoscopic surgery: what is the best surgical approach for symptomatic isthmocele? A systematic review and meta-analysis.

Arch Gynecol Obstet 2020 01 27;301(1):33-52. Epub 2020 Jan 27.

Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Purpose: To investigate the effectiveness and risks of different surgical therapies for isthmocele in symptomatic women with abnormal uterine bleeding, infertility, or for the prevention of obstetric complications, considering safety and surgical complications.

Methods: PubMed/MEDLINE, Scopus, Embase, Science Direct, and Cochrane Library were systematically searched (n° CRD4201912035) for original articles on the surgical treatment of isthmocele published between 1950 and 2018. Data synthesis was completed using MedCalc 16. Read More

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http://dx.doi.org/10.1007/s00404-020-05438-0DOI Listing
January 2020
1.279 Impact Factor

Current and novel mapping substances in gynecologic cancer care.

Int J Gynecol Cancer 2020 Mar 17;30(3):387-393. Epub 2020 Jan 17.

Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

Many tracers have been introduced into current medical practice with the purpose of improving lymphatic mapping techniques, anatomic visualization, and organ/tissue perfusion assessment. Among them, three tracers have dominated the field: indocyanine green, technetium-99m radiocolloid (Tc99), and blue dye. Tc99 and blue dye are used individually or in combination; however, given particular challenges with these tracers, such as the need for a preoperative procedure by nuclear medicine and cost, other options have been sought. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001078DOI Listing

Adjuvant chemotherapy in endometrial cancer.

Cancer Chemother Pharmacol 2020 Mar 16;85(3):477-486. Epub 2020 Jan 16.

Medical Oncology Department, Hospital Universitario Infanta Sofía, Avenida de Europa 34, 28702, San Sebastián de Los Reyes, Madrid, Spain.

The role of adjuvant chemotherapy (CT) is controversial in endometrial carcinoma (EC). Surgery alone is usually curative for women who are at a low risk of disease recurrence. The treatment of EC following surgical staging is based on the risk of relapse, which is defined by the cancer stage at diagnosis, histology of the tumor and other prognostic factors such as grade differentiation, the presence of substantial lymphovascular invasion (LVSI), or depth of myometrial invasion (MI). Read More

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http://dx.doi.org/10.1007/s00280-019-04027-6DOI Listing

Impact of human papillomavirus vaccination on rates of abnormal cervical cytology and histology in young New Zealand women.

N Z Med J 2020 01 17;133(1508):72-84. Epub 2020 Jan 17.

Department of Obstetrics and Gynaecology, University of Otago, Christchurch; Christchurch Women's Hospital, Christchurch.

Aim: Determine the impact of quadrivalent human papillomavirus (HPV) vaccination on abnormal cervical cytology and histology rates in young New Zealand women.

Methods: Retrospective population-based cohort study of women born 1990-1994, with a cervical cytology or histology recorded when aged 20-24 between 1 January 2010 and 31 December 2015. Data was obtained through linking the National Immunisation Register and National Cervical Screening Programme Register. Read More

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January 2020

Choriocarcinoma After Normal Vaginal Delivery; A Rare Entity.

J Ayub Med Coll Abbottabad 2019 Oct-Dec;31(4):629-630

Ayub Medical College, Abbottabad, Pakistan.

Choriocarcinoma is a malignant gestational trophoblastic neoplasm with rare postpartum presentation. Its manifestation after full term delivery is very rare with paucity of data reported from Pakistan. We received a patient in the postpartum period with symptoms of distant metastasis. Read More

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Role Of Papanicolaou Smear In Mapping Out Cervical Epithelial Morphology In Women With Infertility: Modified Bethesda Classification.

J Ayub Med Coll Abbottabad 2019 Oct-Dec;31(4):558-562

Institute of Basic Medical sciences, KMU, Peshawar, Pakistan.

Background: Papinocolaou smear (PAP) smear has a specificity of 98% in detecting early changes in cervical epithelium in women above 21 years, thus its avocation as a screening tool for cervical cancers worldwide. In Pakistan with a lack of awareness in our population as well as socioeconomic conditions there is no such screening program. Infertility on the other hand affects 22% of women in Pakistan and thus one of the most common cause of physician visits. Read More

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A Novel Technique to Minimize Contamination for Cervical Cancer Surgery Patients.

J Minim Invasive Gynecol 2020 Jan 11. Epub 2020 Jan 11.

Departments of Gynecologic Oncology (Drs. Martino and Thomas and Ms. Johnson, Ms. Wejkszner, and Ms. Makarova); Plastic Surgery (Dr. Jacobs); Obstetrics and Gynecology (Dr. Lazaro), Lehigh Valley Health Network, Allentown, Pennsylvania; Department of Gynecologic Oncology, Ohio State University (Drs. Bixel and Fowler), Columbus, Ohio.

The Laparoscopic Approach to Cervical Cancer (LACC) trial changed the surgical management of cervical cancer worldwide. It was a multinational phase III clinical trial that reported lower survival and higher rate of abdominopelvic recurrences in minimally invasive surgery (MIS) than those of open surgery after hysterectomy. It is possible that tumor exposure to the peritoneal cavity in the MIS arm may account for these differences. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.01.006DOI Listing
January 2020

Lower extremity lymphedema in patients with gynecologic malignancies.

Int J Gynecol Cancer 2020 02 7;30(2):252-260. Epub 2020 Jan 7.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York City, New York, USA

Lower extremity lymphedema is a chronic, often irreversible condition that affects many patients treated for gynecologic malignancies, with published rates as high as 70% in select populations. It has consistently been shown to affect multiple quality of life metrics. This review focuses on the pathophysiology, incidence, trends, and risk factors associated with lower extremity lymphedema secondary to the treatment of cervical, endometrial, ovarian, and vulvar cancers in the era of sentinel lymph node mapping. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001032DOI Listing
February 2020

Vaginal carcinoma after cervical dysplasia.

Int J Gynecol Cancer 2020 02 6;30(2):265-273. Epub 2020 Jan 6.

A.C.Camargo Cancer Center, Sao Paulo, Brazil.

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http://dx.doi.org/10.1136/ijgc-2019-001062DOI Listing
February 2020

Understanding the proportion of cervical cancers attributable to HPV.

Med J Aust 2020 02 7;212(2):63-64.e1. Epub 2020 Jan 7.

VCS Foundation, Melbourne, VIC.

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http://dx.doi.org/10.5694/mja2.50477DOI Listing
February 2020

Sister Mary Joseph's nodule in endometrial cancer: A case report and review of the literature.

J Cancer Res Ther 2019 Oct-Dec;15(6):1408-1410

Department of Women and Children Health, Gynecologic Oncology Unit, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Università Cattolica del Sacro Cuore, Roma, Italia.

Sister Mary Joseph's nodule (SMJN) is an umbilical mass referring to an intraabdominal and/or pelvic tumor's metastasis. SMJN is frequently associated with gynecological malignancies, but only 30 cases of SMJN originated from endometrial cancer have been described in the literature. We reported a case of SMJN detected within the primary diagnosis of endometrial cancer, in which a 1-year vaginal relapse occurs. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_523_18DOI Listing
January 2020

Cervical carcinosarcoma presented in advanced stage after high grade cervical displasia.

J Exp Ther Oncol 2019 Dec;13(2):165-167

University of Health Sciences Tepecik Education and Research Hospital, İzmir, Turkey.

Objective: Cervical carcinosarcomas (Malignant Mixed Mullerian Tumour [MMMT] ) are very rare neoplasms. Fewer than 100 cases were documented until recently. Because of the rarity, etiologic factors, prognosis and treatment modalities are unclear. Read More

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December 2019

[Problem of the carbon dioxide embolism during the procedure of transanal total mesorectal excision].

Authors:
D S Liu H Zhang

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Dec;22(12):1110-1114

Department of Colorectal Tumor Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, China.

Carbon dioxide embolization is a special complication of laparoscopic colorectal surgery. It is rarely reported in conventional laparoscopic colorectal surgery, and has not been well recognized by surgeons. Transanal total mesorectal excision (taTME) is an increasingly popular sphincter-preserving surgery for low rectal cancer in recent years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1671-0274.2019.12.003DOI Listing
December 2019

HPV swab self-collection and cervical cancer in women who have sex with women.

Med J Aust 2020 02 24;212(3):106-107.e1. Epub 2019 Dec 24.

Mercy Hospital for Women, Melbourne, VIC.

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http://dx.doi.org/10.5694/mja2.50457DOI Listing
February 2020

A comparison of disease recurrence between robotic versus laparotomy approach in patients with intermediate-risk endometrial cancer.

Int J Gynecol Cancer 2020 02 22;30(2):160-166. Epub 2019 Dec 22.

Radiation Oncology, The Ottawa Hospital, Ottawa, Ontario, Canada.

Objective: Advances in minimally invasive surgery, particularly with robotic surgery, have resulted in improved peri-operative outcomes in patients with endometrial cancer. In addition, randomized trials have shown that addition of adjuvant radiotherapy following surgery improves loco-regional disease control among stage I intermediate-risk endometrial cancer patients. We aimed to investigate the efficacy and safety of combined treatment of robotic surgery and adjuvant radiotherapy in this patient population. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000838DOI Listing
February 2020

Lessons from radiochemotherapy and modern image-guided adaptive brachytherapy followed by hysterectomy.

Gynecol Oncol 2020 02 18;156(2):328-334. Epub 2019 Dec 18.

Department of Radiation Oncology, Institut Paoli-Calmettes, Marseille, France.

Purpose: To analyze the clinical outcomes and the safety of radiochemotherapy (RCT) and image-guided adaptive brachytherapy (IGABT) and to evaluate the impact of hysterectomy (HT) as completion of treatment for cervical cancer.

Methods And Materials: 145 patients with locally advanced cervical cancer were treated at our institution. Patients underwent RCT and IGABT, then hysterectomy (HT) as completion of treatment was performed, with the exception of patients with surgical contraindications, para aortic metastatic disease or patients who refused surgery. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.12.001DOI Listing
February 2020

Unindicated hysterectomies in India: the aftermath.

Authors:
Amenda Ann Davis

BMJ Case Rep 2019 Dec 17;12(12). Epub 2019 Dec 17.

Resident, Obstetrics and Gynaecology, All India Institute of Medical Sciences, Delhi, India

Unindicated hysterectomy is a disturbing problem in India. Women are counselled into the procedure by the fear of cancer, and by reinforcing their notion that unrelated somatic problems are solved by the removal of the uterus. This is a case of a woman from the state of Bihar, India, who was referred to us after an unindicated hysterectomy at the age of 24, performed as a first-line treatment for lower abdominal pain. Read More

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http://dx.doi.org/10.1136/bcr-2019-230129DOI Listing
December 2019

[Papsmears: An endless story of an announced death?]

Ann Pathol 2019 Dec;39(6):375-377

Département de pathologie, université Paris Centre, hôpital Cochin, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.annpat.2019.10.003DOI Listing
December 2019

[Comparison of high-risk human papillomavirus infection rate and genotype distribution between Han and Mongolian women].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Nov;40(11):1439-1444

Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To understand the infection rate and genotype distribution of high risk-human papillomavirus (HR-HPV) and the detection rate of different grades of cervical lesions in Han and Mongolian women in China and provide evidence for the development of screening and vaccination strategies for the prevention and control of cervical cancer in different ethnic groups. In June 2017, a multicenter, population-based study for cervical cancer screening in low-resource settings in China was conducted in three rural areas: Xiangyuan and Yangcheng counties in Shanxi province, and Etuoke county in Inner Mongolia Autonomous Region. A total of 9 517 women aged 30-65 years were included in the study, and two cervical and vaginal secretion samples were collected from them for HPV and PCR-based HPV DNA tests. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.11.018DOI Listing
November 2019

The Cost-Effectiveness Analysis of Cervical Cancer Screening Using a Systematic Invitation System in Lithuania.

Int J Environ Res Public Health 2019 12 11;16(24). Epub 2019 Dec 11.

Department of Preventive Medicine, Faculty of Public Health, Medical Academy, Lithuanian University of Health Sciences, 47181 Kaunas, Lithuania.

In Lithuania, cytological screening of cervical cancer (CC) is largely opportunistic. Absence of standardized systematic invitation practice might be the reason for low participation rates. The study aimed to assess the cost-effectiveness of systematic invitation approach in CC screening programme from the perspective of a healthcare provider. Read More

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http://dx.doi.org/10.3390/ijerph16245035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950560PMC
December 2019

Comparison of two invitation-based methods for human papillomavirus (HPV) self-sampling with usual care among un- and under-screened Māori, Pacific and Asian women: study protocol for a randomised controlled community trial to examine the effect of self-sampling on participation in cervical-cancer screening.

BMC Cancer 2019 12 9;19(1):1198. Epub 2019 Dec 9.

Centre for Public Health Research, Massey University, Wellington, New Zealand.

Background: Māori, Pacific and Asian women in New Zealand have lower cervical-cancer screening rates than European women, and there are persistent inequities in cervical cancer outcomes for Māori and Pacific women. Innovative ways to address access barriers are required. New Zealand is transitioning to screening with human papillomavirus (HPV) DNA testing, which could allow women themselves, rather than a clinician, to take the sample. Read More

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http://dx.doi.org/10.1186/s12885-019-6401-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902319PMC
December 2019