20,596 results match your criteria Surgical Treatment of Vaginal Cancer

Topical Imiquimod for the Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix: A Randomized Controlled Trial.

Obstet Gynecol 2021 May 6. Epub 2021 May 6.

Department of Prevention, the Department of Gynecological Oncology, the Department of Pathology, and the Research and Teaching Institute, Barretos Cancer Hospital, Barretos, São Paulo, Brazil; the Department of Gynecologic Oncology and Reproductive Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas; the Department of Obstetrics and Gynecology, Federal University of Health Sciences of Porto Alegre/Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Brazil; and the Teaching Superintendence, A.C. Camargo Cancer Center, São Paulo, Brazil.

Objective: To evaluate the histologic response rate of high-grade squamous intraepithelial lesions (HSIL) of the cervix after topical application of 5% imiquimod cream.

Methods: In this phase II trial, women with cervical HSIL (cervical intraepithelial neoplasia [CIN] 2-3) were randomly assigned to 250 mg of 5% imiquimod cream applied to the cervix weekly for 12 weeks, followed by loop electrosurgical excision procedure (LEEP) without preceding treatment. The sample size was calculated based on the HSIL regression rates previously reported by Grimm et al. Read More

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Preliminary clinical outcomes of patients treated with vaginal brachytherapy alone using multi-channel vaginal brachytherapy applicator in operated early-stage endometrial cancer.

Rep Pract Oncol Radiother 2021 25;26(1):43-49. Epub 2021 Feb 25.

Department of Surgical Oncology, Sri Shankara Cancer Hospital and Research Center, Bangalore, India.

Background: Recommendations for adjuvant treatment for postoperative, early-stage endometrial cancer varies from observation through vaginal brachytherapy alone to pelvic radiation. While observation alone can lead to recurrence, external radiotherapy has increased morbidity. The aim of this study is to show our results with vaginal brachytherapy alone using a multichannel applicator for treatment of early-stage endometrial cancer. Read More

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February 2021

Aggressive Resection of Malignant Paraaortic and Pelvic Tumors Accompanied by Arterial Reconstruction with Synthetic Arterial Graft.

Am J Case Rep 2021 May 1;22:e931569. Epub 2021 May 1.

Department of Surgery, Shiga General Hospital, Moriyama, Shiga, Japan.

BACKGROUND Advanced malignancies in the lower abdomen easily invade the retroperitoneal and pelvic space and often metastasize to the paraaortic and pelvic lymph nodes (LNs), resulting in paraaortic and/or pelvic tumor (PPT). CASE REPORT A total of 7 cases of aggressive malignant PPT resection and orthotopic replacement of the abdominal aorta and/or iliac arteries with synthetic arterial graft (SAG) were experienced during 16 years. We present our experience with aggressive resection of malignant PPTs accompanied by arterial reconstruction with SAG in detail. Read More

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Triaging HPV-positive, cytology-negative cervical cancer screening results with extended HPV genotyping and p16 immunostaining in China.

BMC Infect Dis 2021 Apr 30;21(1):400. Epub 2021 Apr 30.

Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, 1120 Lianhua Road, Shenzhen, Guangdong, 518036, P. R. China.

Background: Self-sampling for human papillomavirus (HPV) testing is a feasible option to improve the cervical screening coverage. However, an ideal triage method for HPV-positive self-samples does not yet exist. The aim of this study was to explore the utility of HPV genotyping and p16 immunostaining (p16) in triaging HPV-positive self-samples, focusing on HPV-positive, cytology-negative (HPCN) women. Read More

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Menstural function preservation treatment of a primary vaginal clear cell carcinoma with ovarian transposition and vaginal brachytherapy.

Gynecol Oncol Rep 2021 May 8;36:100764. Epub 2021 Apr 8.

1st Department of Obstetrics and Gynecology, University of Athens, Greece.

Early stage vaginal carcinomas are typically treated with radical surgical procedures or radiation therapy. Both modalities impair the reproductive ability of the patients. We hereby report a case of menstrual function preservation in a 24-year-old patient with an early-stage primary vaginal clear cell carcinoma. Read More

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[Performance of vaginal self-sampling high-risk HPV genotyping as primary and combining cytology or viral load as secondary in cervical cancer screening].

Zhonghua Fu Chan Ke Za Zhi 2021 Apr;56(4):271-279

Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Institute of Obstetrics and Gynecology, Shenzhen Peking University-Hong Kong University of Science and Technology Medical Center, Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecological Diseases, Shenzhen 518000, China.

To evaluate the efficacy of high-risk HPV (HR-HPV) genotyping with vaginal self-sampling in primary screening and combining cytology or viral load for HR-HPV positive as secondary screening strategies. The data referring to HR-HPV genotyping of self-collected sample with mass array matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF-MS), HR-HPV viral load of physician-collected sample with hybrid capture Ⅱ (HC-Ⅱ), liquid-based cytology and histology of 8 556 women were from Shenzhen cervical cancer screening trial Ⅱ (SHENCCAST-Ⅱ) conducted between April 2009 and April 2010. The data were reanalyzed to determine the sensitivity and specificity to cervical intraepithelial neoplasia (CIN) of grade 2 or worse (CIN Ⅱ), CIN of grade 3 or worse (CIN Ⅲ) when HR-HPV genotyping combining with colposcopy as primary screening strategy based on varied HR-HPV subtype (strategy 1, including 5 sub-strategies: 1a: HPV 16/18 positive; 1b: HPV 16/18/58 positive; 1c: HPV 16/18/58/31/33 positive; 1d: HPV 16/18/58/31/33/52 positive; 1e: any HR-HPV positive). Read More

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Adjuvant vaginal interventional radiotherapy in early-stage non-endometrioid carcinoma of corpus uteri: a systematic review.

J Contemp Brachytherapy 2021 Apr 14;13(2):231-243. Epub 2021 Apr 14.

Department of Medicine and Surgery and Translational Medicine, Radiotherapy Oncology, Sant' Andrea Hospital, "Sapienza" University, Rome, Italy.

Purpose: This systematic review focused on rare histological types of corpus uteri malignancy, including uterine carcinosarcoma (UCS), uterine clear cell carcinoma (UCCC), and uterine papillary serous carcinoma (UPSC), and it is proposed to assist with clinical decision-making. Adjuvant treatment decisions must be made based on available evidences. We mainly investigated the role of vaginal interventional radiotherapy (VIRt) in UCS, UCCC, and UPSC managements. Read More

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Minimally invasive radical trachelectomy: Considerations on surgical approach.

Best Pract Res Clin Obstet Gynaecol 2021 Feb 20. Epub 2021 Feb 20.

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Current evidence supports that radical trachelectomy is a safe and feasible alternative to patients with early-stage cervical cancer who wish to preserve fertility. In addition, published retrospective literature supports that oncologic outcomes are equivalent to those of radical hysterectomy. First published as a vaginal approach, a number of other approaches have been reported including laparotomic, laparoscopic, and robotic. Read More

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February 2021

Cervical Cancer Screening-Past, Present, and Future.

Cancer Epidemiol Biomarkers Prev 2021 03;30(3):432-434

Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.

Cervical cancer screening has undergone a transformation in recent decades. Historically, programs were based on cervical cytology (i.e. Read More

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Fertility-sparing treatment in cervical cancer: Abdominal trachelectomy.

Best Pract Res Clin Obstet Gynaecol 2021 Feb 22. Epub 2021 Feb 22.

Morehouse School of Medicine, Department of Ob-Gyn, Gynecologic Oncology, 720 Westview Drive Atlanta, GA 30310, USA. Electronic address:

In the last two decades, great strides have been made to treat cancer while sparing fertility for young women. This is at least partly in response to changing demographics, including delayed childbearing and fewer historically traditional couples. The trachelectomy has become emblematic in this endeavor. Read More

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February 2021

Hidradenoma papilliferum of the hymen: a case report.

J Med Case Rep 2021 Apr 13;15(1):162. Epub 2021 Apr 13.

Department of Gynaecology and Obstetrics, Akdeniz University Hospital, Antalya, Turkey.

Background: Hidradenoma papilliferum is a rare benign neoplasm arising from apocrine glands. It occurs commonly on the anogenital region of middle-aged women. It usually presents as a slow growing, solitary asymptomatic, skin colored or red nodule less than 1 cm in diameter. Read More

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Screening for HPV and dysplasia in transgender patients: Do we need it?

Eur J Obstet Gynecol Reprod Biol 2021 May 31;260:177-182. Epub 2021 Mar 31.

Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address:

Introduction: Aim of this study was the evaluation of prevalence of HPV infection and resulting genital dysplasia to assess the necessity and reasonability of pap smears and HPV testing in transgender patients. HPV is the most common sexually transmitted infection and responsible for the majority of genital dysplasias and malignancies. However, few data exist about the prevalence of HPV and dysplasia in transgender people. Read More

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[Application of artificial intelligence-assisted diagnosis for cervical liquid-based thin-layer cytology].

Zhonghua Bing Li Xue Za Zhi 2021 Apr;50(4):333-338

Department of Pathology, Nanfang Hospital and Basic Medical College, Southern Medical University, Guangzhou 510515, China.

To explore the application value of artificial intelligence-assisted diagnosis system for TBS report in cervical cancer screening. A total of 16 317 clinical samples and related data of cervical liquid-based thin-layer cell smears, which were obtained from July 2020 to September 2020, were collected from Southern Hospital, Guangzhou Huayin Medical Inspection Center, Shenzhen Bao'an People's Hospital(Group) and Changsha Yuan'an Biotechnology Co., Ltd. Read More

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Treatment Outcomes of Early Carcinoma Cervix Before and After Sub-specialization.

Indian J Surg Oncol 2021 Mar 28;12(1):78-85. Epub 2020 Sep 28.

Department of Gynaecologic Oncology, Christian Medical College, Vellore, 632004 India.

This study aimed to compare the treatment outcomes in carcinoma cervix before and after gynecologic oncology sub-specialization at a tertiary care hospital, in India. This was a retrospective cohort study comparing women with operable cervical cancer who underwent radical hysterectomy before and after gynecologic oncology sub-specialization. Electronic medical records of women operated for early carcinoma cervix between 2001 and 2010 and 2011-2015 were reviewed and compared for treatment and oncological outcomes. Read More

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The safety and efficacy of a novel method for treatment of HSIL.

Arch Gynecol Obstet 2021 Apr 3. Epub 2021 Apr 3.

Department of Obstetrics and Gynecology, Peking University First Hospital, Xicheng District, Beijing, 100034, China.

Purpose: To investigate the efficacy and safety of Nr-CWS on treatment of cervical HSIL.

Method: In this observational study, 16 patients were treated with Nr-CWS 1 time every 2 days for 6 times as one-course group (OC group), the other 184 patients were treated with Nr-CWS 1 time every 2 days for 12 times between 2 menstruations as two-course group (TC group). The medical information including age, HPV assay, vaginal-cervical cytology, and the pathological result of biopsy before and after treatment was collected. Read More

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Recurrent and metastatic female adnexal tumor of probable Wolffian origin: A case report and review of the literature.

Medicine (Baltimore) 2021 Apr;100(13):e25377

Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University.

Rationale: Female adnexal tumors of probable Wolffian origin (FATWOs) are rare gynecologic neoplasms arising from the mesonephric duct remnants. Less than 90 cases have been reported in the English literature. Although most cases of FATWO are considered benign, recurrence and metastasis may occur in very few cases during the course of the disease. Read More

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Clinicopathological analysis of ovarian sertoli-leydig cell tumor with postmenopausal vaginal bleeding as the first symptom: A case report.

Medicine (Baltimore) 2021 Apr;100(13):e24922

Department of Obsterics and Gynecology, Hubei Maternal and Child Health Hospital Affiliated to Huazhong University of Science and Technology, Wuhan, China.

Rational: Ovarian sertoli-leydig cell tumor (OSLCT) is extremely rare. We reported a OSLCT case in whom postmenopausal vaginal bleeding was the first symptom.

Patient Concerns: The patient came to our hospital due to postmenopausal vaginal bleeding. Read More

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Transvaginal polytetrafluoroethylene mesh surgery for pelvic organ prolapse: 1-year clinical outcomes.

Int J Urol 2021 03 28;28(3):268-272. Epub 2020 Nov 28.

Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan.

Objectives: To evaluate the safety and efficacy of transvaginal mesh surgery using a polytetrafluoroethylene mesh to treat pelvic organ prolapse.

Methods: This prospective observational study included women undergoing transvaginal mesh surgery for pelvic organ prolapse that used new polytetrafluoroethylene mesh cut into a shape similar to that of Elevate. We evaluated the subjective and objective outcomes at 3 and 12 months, as well as postoperative complication rates. Read More

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Endometrial polyps. An evidence-based diagnosis and management guide.

Eur J Obstet Gynecol Reprod Biol 2021 May 13;260:70-77. Epub 2021 Mar 13.

Department of Obstetrics, Gynecology and Reproductive Sciences, Minimally Invasive Gynecology Division, University of Miami, Miller School of Medicine, 1321 NW 14(th) Street Suite 201, Miami, FL 33136, USA. Electronic address:

Objective: To provide an updated practice guideline for the management of patients with endometrial polyps.

Materials And Methods: A committee of six expert researchers draw the recommendations according to AGREE II Reporting Guideline. An electronic search was performed querying the following databases MEDLINE (accessed through PubMed), Scopus, PROSPERO, EMBASE, CINAHL, Cochrane Library (including the Cochrane Database of Systematic Reviews), Scielo. Read More

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Clinical presentation, treatment, and outcomes associated with vaginal intraepithelial neoplasia: A retrospective study of 118 patients.

J Obstet Gynaecol Res 2021 May 23;47(5):1624-1630. Epub 2021 Mar 23.

Department of Obstetrics & Gynecology, Tianjin Medical University, Tianjin, China.

The incidence of vaginal intraepithelial neoplasia (VAIN) is increasing annually; however, the reported values are likely underestimated. Risk factors for VAIN include advanced age, human papillomavirus (HPV) infection, history of hysterectomy, and simultaneous or previous cervical intraepithelial neoplasia (CIN) or cervical cancer cervical cancer. The most common presentation is abnormal cytology without clinical symptoms. Read More

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Microablative Fractional CO Laser for Vulvovaginal Atrophy in Women With a History of Breast Cancer: A Pilot Study at 4-week Follow-up.

Clin Breast Cancer 2021 Feb 23. Epub 2021 Feb 23.

School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; Division of Gynecology and Obstetrics, Urogynecology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Background: Breast cancer (BC) is the most common female cancer worldwide. Menopausal symptoms are a well-known side effect in women with BC and have a significant negative impact on quality of life (QoL) and sexuality. Nowadays, hormonal replacement therapy and local estrogens are the most common prescriptions to treat vulvovaginal (VVA) symptoms. Read More

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February 2021

Clinical implications of transitioning from cytology to human papillomavirus-based cervical cancer screening.

Acta Obstet Gynecol Scand 2021 03;100(3):371-372

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.

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A rare case of nevus sebaceous of the bilateral labia minora: A case report and review of literature.

Medicine (Baltimore) 2021 Mar;100(10):e25047

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital.

Rationale: Nevus sebaceous (NS) is a lesion caused by congenital hyperplastic disorder of the sebaceous glands. It commonly noted in the scalp and face and rarely in the trunk, neck, or oral mucosa. We present a rare case of a lesion arising in the genital region. Read More

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Successful laparoscopy-assisted repair of a rectovaginal fistula after low anterior resection for rectal cancer: a report of two cases.

Surg Case Rep 2021 Mar 16;7(1):68. Epub 2021 Mar 16.

Department of Comprehensive Surgery, Shiga University of Medical Science, Seta-tsukinowa cho, Otsu, Shiga, 520-2192, Japan.

Background: Rectovaginal fistula (RVF) after low anterior resection for rectal cancer is troublesome and refractory. Although various surgical procedures have been previously described, no definitive procedure has shown a satisfactory outcome. We present two consecutive Japanese patients who underwent successful surgery for an RVF after low anterior resection. Read More

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Maternal and neonatal outcomes in planned versus emergency cesarean delivery for placenta accreta spectrum: A multinational database study.

Acta Obstet Gynecol Scand 2021 03 12;100 Suppl 1:41-49. Epub 2021 Mar 12.

Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.

Introduction: Placenta accreta spectrum (PAS) is a condition often resulting in severe maternal morbidity. Scheduled delivery by an experienced team has been shown to improve maternal outcomes; however, the benefits must be weighed against the risk of iatrogenic prematurity. The aim of this study is to investigate the rates of emergency delivery seen for antenatally suspected PAS and compare the resulting outcomes in the 15 referral centers of the International Society for PAS (IS-PAS). Read More

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Redox-sensitive signalling pathways regulated by human papillomavirus in HPV-related cancers.

Rev Med Virol 2021 Mar 11:e2230. Epub 2021 Mar 11.

Laboratorio F-315, Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, México City, México.

High-risk human papillomavirus (HR-HPV) chronic infection is associated with the induction of different HPV-related cancers, such as cervical, anus, vaginal, vulva, penis and oropharynx. HPV-related cancers have been related to oxidative stress (OS), where OS has a significant role in cancer development and maintenance. Surgical resection is the treatment of choice for localised HPV-related cancers; however, these malignancies commonly progress to metastasis. Read More

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Radical trachelectomy.

Int J Gynecol Cancer 2021 Mar 11. Epub 2021 Mar 11.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Radical trachelectomy is the 'cornerstone' of fertility-sparing surgery in patients with early-stage cervical cancer wishing to preserve fertility. Growing evidence has demonstrated the oncologic safety and subsequent favorable pregnancy outcomes in well-selected cases. In the absence of prospective trials, the decision on the appropriate surgical approach (vaginal, open, or minimally invasive surgery) should be based on local resources and surgeons' preferences. Read More

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Sentinel lymph node (SLN) isolated tumor cells (ITCs) in otherwise stage I/II endometrioid endometrial cancer: To treat or not to treat?

Gynecol Oncol 2021 May 5;161(2):347-352. Epub 2021 Mar 5.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Objectives: To assess associations between treatment and recurrence-free survival (RFS) among patients with isolated tumor cells (ITCs) in sentinel lymph nodes (SLN) and otherwise stage I/II endometrioid endometrial cancer (EC).

Methods: A multi-institutional retrospective study of patients with SLN ITCs (<200 cells and < 0.2 mm) was performed. Read More

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A Multi-Institutional Analysis of Adjuvant Chemotherapy and Radiation Sequence in Women With Stage IIIC Endometrial Cancer.

Int J Radiat Oncol Biol Phys 2021 Mar 5. Epub 2021 Mar 5.

Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

Purpose: Our purpose was to evaluate the effect of sequence and type of adjuvant therapy for patients with stage IIIC endometrial carcinoma (EC) on outcomes.

Methods And Materials: In a multi-institutional retrospective cohort study, patients with stage IIIC EC who had surgical staging and received both adjuvant chemotherapy and radiation therapy (RT) were included. Adjuvant treatment regimens were classified as adjuvant chemotherapy followed by sequential RT (upfront chemo), which was predominant sequence; RT with concurrent chemotherapy followed by chemotherapy (concurrent); systemic chemotherapy before and after RT (sandwich); adjuvant RT followed by chemotherapy (upfront RT); or chemotherapy concurrent with vaginal cuff brachytherapy alone (chemo-brachy). Read More

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GnRH analogue followed by surgery in treatment of vaginal leiomyoma-a case report.

Medicine (Baltimore) 2021 Feb;100(8):e24911

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China.

Rationale: Vaginal leiomyoma is a rare type of leiomyoma that occurs on the wall of vagina. Treatment for vaginal leiomyoma is varied and is based on the location and size of the leiomyoma.

Patient Concerns: In this case, a 24-year-old newly married Chinese woman complained of dyspareunia. Read More

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February 2021