3,202 results match your criteria Surgical Treatment of Tremor


Essure removal: comparison of two minimally invasive approaches.

Fertil Steril 2020 Jul;114(1):187-188

Instituto de Salud de la Mujer José Botella Llusiá, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain.

Objective: To study differences between robotic and laparoscopic approach in Essure device removal.

Design: Demonstration video of two different surgical approaches.

Setting: Clinico San Carlos University Hospital in Madrid, Spain. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2020.03.025DOI Listing

Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review.

Neuromodulation 2020 Jun 24. Epub 2020 Jun 24.

Department of Neurology, Program for Movement Disorders and Neurorestoration, Fixel Institute for Neurological Diseases at the University of Florida, Gainesville, FL, USA.

Objective: We aimed to formulate a practical clinical treatment algorithm for Holmes's tremor (HT) by reviewing currently published clinical data.

Materials And Methods: We performed a systematic review of articles discussing the management of HT published between January 1990 and December 2018. We examined data from 89 patients published across 58 studies detailing the effects of pharmacological or surgical interventions on HT severity. Read More

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http://dx.doi.org/10.1111/ner.13220DOI Listing

Efficacy of levetiracetam on upper limb movement in multiple sclerosis patients with cerebellar signs: a multicenter double-blind, placebo-controlled, crossover study.

Eur J Neurol 2020 Jun 17. Epub 2020 Jun 17.

Department of Medical, Surgical Science and Advanced Technology "GF Ingrassia", University of Catania, Catania, Italy.

Background: The literature provides contrasting results on the efficacy of levetiracetam (LEV) in multiple sclerosis (MS) patients with cerebellar signs. We sought to evaluate the efficacy of LEV on upper limb movement in MS patients.

Methods: In this multicenter double-blind placebo-controlled crossover study, MS patients with prevalently cerebellar signs were randomly allocated into two groups: LEV followed by placebo (Group 1) or placebo followed by LEV (Group 2). Read More

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http://dx.doi.org/10.1111/ene.14403DOI Listing

Association of Weight-Adjusted Caffeine and β-Blocker Use With Ophthalmology Fellow Performance During Simulated Vitreoretinal Microsurgery.

JAMA Ophthalmol 2020 Jun 11. Epub 2020 Jun 11.

Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, Brazil.

Importance: Vitreoretinal surgery can be technically challenging and is limited by physiologic characteristics of the surgeon. Factors that improve accuracy and precision of the vitreoretinal surgeon are invaluable to surgical performance.

Objectives: To establish weight-adjusted cutoffs for caffeine and β-blocker (propranolol) intake and to determine their interactions in association with the performance of novice vitreoretinal microsurgeons. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2020.1971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290718PMC

Postoperative outcomes after total hip arthroplasty in patients with Parkinson disease: A protocol of case control study.

Medicine (Baltimore) 2020 May;99(19):e20018

Department of Ophthalmology, People's Hospital of Dujiangyan, Sichuan Province, China.

Background: Parkinson disease (PD) is a progressive neuromuscular disease associated with bradykinesia, tremor, and postural instability. We aimed to compare outcomes and complications of total hip arthroplasty (THA) between patients with PD and those without.

Methods: A single institution retrospective cohort from 2000 to 2018 was reviewed. Read More

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http://dx.doi.org/10.1097/MD.0000000000020018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220782PMC
May 2020
5.723 Impact Factor

Rest tremor in dystonia: epidemiology, differential diagnosis, and pathophysiology.

Neurol Sci 2020 Apr 23. Epub 2020 Apr 23.

Department of Neurology, Govind Ballabh Pant Postgraduate Institute of Medical Education and Research, Academic Block, Room No. 503, New Delhi, 110002, India.

Background: The most common type of tremor reported in dystonia patients is postural and kinetic. There is uncertainty regarding the prevalence of rest tremor in dystonia.

Objective: This review focuses on the clinical and neurophysiological features of rest tremor in dystonia, its differential diagnosis, and methods to distinguish it from other rest tremor syndromes. Read More

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http://dx.doi.org/10.1007/s10072-020-04402-9DOI Listing

Patient selected goals and satisfaction after bilateral subthalamic nucleus deep brain stimulation in Parkinson's disease.

J Clin Neurosci 2020 Jun 17;76:148-153. Epub 2020 Apr 17.

Department of Neurology and Movement Disorder Center, Neuroscience Research Institute, College of Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address:

Assessing patient goals is crucial in understanding patient centered outcomes and satisfaction. However, patient goals may change throughout treatment. Our objective is to identify the changes in patient-selected goals of Parkinson's disease (PD) patients undergoing bilateral subthalamic nucleus deep brain stimulation (STN-DBS) and examine the relationship among patient-selected goal achievement, standard DBS outcome measures, and overall patient satisfaction. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.04.005DOI Listing

Current and Emerging Treatments of Essential Tremor.

Neurol Clin 2020 05 29;38(2):309-323. Epub 2020 Feb 29.

Movement Disorders-Methodist Neurological Institute, Weill Cornel Medical School, 6560 Fannin Suite 1002, Houston, TX 77025, USA. Electronic address:

Established medications that improve tremor include beta-adrenergic antagonists, primidone, topiramate, and ethanol. Less consistent efficacy is reported with many other medications, usually antiepileptic drugs. A number of investigational medications, including T-type calcium channel blockers and allosteric gamma-aminobutyric acid-A modulators, are being developed for tremor. Read More

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http://dx.doi.org/10.1016/j.ncl.2020.01.002DOI Listing

Magnetic Resonance-Guided Focused Ultrasound Thalamotomy to Treat Essential Tremor in Nonagenarians.

Stereotact Funct Neurosurg 2020 30;98(3):182-186. Epub 2020 Mar 30.

University Health Network, Toronto, Ontario, Canada,

Essential tremor (ET) is a disabling movement disorder that is most prevalent among the elderly. While deep brain stimulation surgery targeting the ventral intermediate nucleus of the thalamus is commonly used to treat ET, the most elderly patients or those with multiple medical comorbidities may not qualify as surgical candidates. Magnetic resonance-guided focused ultrasound (MRgFUS) constitutes a less invasive modality that may be used to perform thalamotomy without the need for a burr hole craniotomy. Read More

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http://dx.doi.org/10.1159/000506817DOI Listing
March 2020
1.477 Impact Factor

[Functional stereotactic radiosurgery: Indications and perspectives].

Cancer Radiother 2020 Apr 24;24(2):166-173. Epub 2020 Mar 24.

Département de neurochirurgie, centre hospitalier universitaire Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France.

Stereotactic radiosurgery (SRS) is a non-invasive technique that enables to create brain focal lesions with a high precision and localization. Thus, functional brain disorders can be treated by SRS in case of pharmacoresistance or inoperability. To date, treatment of trigeminal neuralgia is the most described and known indication. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.01.009DOI Listing

Long-Term Alleviation of Parkinsonian Resting Tremor Using Wireless Optogenetic Nanonetworks.

IEEE Trans Nanobioscience 2020 Jul 12;19(3):403-409. Epub 2020 Mar 12.

Resting tremor is one of the major symptoms of Parkinson's disease, which causes havoc in motor functions of the body, has its genesis in communication impairments in the subthalamic nucleus of the basal ganglia. The modern sophisticated surgical treatments, including electrical deep brain stimulation do not yield satisfactory results due to their inability to provide long-term cure and minimize side effects, such as discomfort and increased infection rates. In this work, we propose a novel system based on the emerging communication technology of wireless optogenetic networks of neural dusts to provide a long-term solution for the alleviation of resting tremor. Read More

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http://dx.doi.org/10.1109/TNB.2020.2979781DOI Listing

Acute Cerebellitis or Postinfectious Cerebellar Ataxia? Clinical and Imaging Features in Acute Cerebellitis.

J Child Neurol 2020 May 12;35(6):380-388. Epub 2020 Mar 12.

Department of Pediatric Neurology, Hacettepe University Ihsan Dogramaci Children's Hospital, Ankara, Turkey.

Acute cerebellitis is a rare condition often considered within the group of acute postinfectious cerebellar ataxia despite its distinctive clinical and imaging features. We retrieved clinical, laboratory, and follow-up data of 15 children diagnosed with acute cerebellitis in our department between 2011 and 2019. There were 10 boys and 5 girls aged 3-15 years, median 9. Read More

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http://dx.doi.org/10.1177/0883073820901407DOI Listing

Bilateral Posterior Subthalamic Area Deep Brain Stimulation for Essential Tremor: A Case Series.

Front Hum Neurosci 2020 5;14:16. Epub 2020 Feb 5.

Department of Functional Neurosurgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Deep brain stimulation (DBS) of the posterior subthalamic area (PSA) provides a potentially effective treatment for medication-refractory essential tremor (ET).

Objective: To study the clinical benefits and adverse-event profile of bilateral PSA-DBS for refractory ET.

Methods: Seven patients with refractory ET underwent bilateral PSA-DBS surgery under general anesthesia between September 2017 and May 2018. Read More

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http://dx.doi.org/10.3389/fnhum.2020.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013085PMC
February 2020

[MR-guided focused ultrasound for treatment of essential tremor].

Ugeskr Laeger 2020 Jan;182(4)

Essential tremor can be a debilitating disease. In many cases, medical treatment is ineffective and/or holds significant side effects. Surgical treatment using deep brain stimulation is only possible in few and selected cases. Read More

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January 2020

Diagnosis and Treatment of Parkinson Disease: A Review.

JAMA 2020 02;323(6):548-560

Department of Neurology, University of Florida College of Medicine, Gainesville.

Importance: Parkinson disease is the most common form of parkinsonism, a group of neurological disorders with Parkinson disease-like movement problems such as rigidity, slowness, and tremor. More than 6 million individuals worldwide have Parkinson disease.

Observations: Diagnosis of Parkinson disease is based on history and examination. Read More

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http://dx.doi.org/10.1001/jama.2019.22360DOI Listing
February 2020

Short- and long-term cognitive effects of deep brain stimulation in the caudal zona incerta versus best medical treatment in patients with Parkinson's disease.

J Neurosurg 2020 Feb 7:1-9. Epub 2020 Feb 7.

2Unit of Functional Neurosurgery, UCL Institute of Neurology, London, United Kingdom; and.

Objective: A growing number of studies are showing positive effects of deep brain stimulation (DBS) in the caudal zona incerta (cZi) in various tremor disorders, as well as motor symptoms of Parkinson's disease (PD). The focus of the present study was to evaluate short- and long-term cognitive effects of bilateral cZi DBS in patients with PD.

Methods: Twenty-five nondemented patients with advanced PD were recruited to participate in a randomized trial of cZi DBS versus best medical treatment (BMT). Read More

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http://dx.doi.org/10.3171/2019.12.JNS192654DOI Listing
February 2020

Focal limb dystonia and tremor: Clinical update.

Toxicon 2020 Mar 13;176:10-14. Epub 2020 Jan 13.

Department of Clinical Neurological Sciences, Western University, London, Canada. Electronic address:

The association between tremor and dystonia has been known for many decades. Dystonic tremor is seen in the body part affected with dystonia. Tremor and dystonia can also co-exist in different body parts. Read More

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http://dx.doi.org/10.1016/j.toxicon.2020.01.004DOI Listing
March 2020
2.492 Impact Factor

Tremor Caused by Dandy-Walker Syndrome Concomitant with Syringomyelia: Case Report and Review of the Literature Review.

World Neurosurg 2020 Apr 16;136:301-304. Epub 2020 Jan 16.

Department of Neurology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical, Hangzhou, Zhejiang, China. Electronic address:

Background: Dandy-Walker Syndrome (DWS) is a rare congenital brain malformation characterized by underdevelopment of cerebellar vermis and cystic enlargement of the fourth ventricle and enlargement of the posterior fossa. The cooccurrence of DWS and syringomyelia in adults is very rare.

Case Description: We report a man aged 19 years who presented with a 2-year history of tremor. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.045DOI Listing

Towards automated patient-specific optimization of deep brain stimulation for movement disorders.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:6159-6162

In this paper we present a simulation framework for automated optimization of deep brain stimulation (DBS) parameters based on the hand kinematics signal as the feedback signal, in patients with essential tremor. We used Gaussian Process regression (GPR) models to develop patient-specific models for predicting the effect of DBS on the hand kinematics using the clinical data that was recorded during DBS programming. In this framework, we characterized the performance of a Bayesian Optimization method to identify the optimal DBS parameters that maximized the clinical efficacy. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8857736DOI Listing

A Clinical Applicable Smartwatch Application for Measuring Hyperkinetic Movement Disorder Severity.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:5867-5870

Measuring the severity of hyperkinetic movement disorders like tremor and myoclonus is challenging. Although many accelerometers are available to quantify movements, the vast majority lacks real-time analysis and an interface that makes it possible to real-time adjust therapy like deep brain stimulation (DBS). Here, we developed a smartwatch/smartphone application that is capable of real-time analysing movement disorder severity. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8857869DOI Listing

Evaluation of Parkinson's Disease at Home: Predicting Tremor from Wearable Sensors.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:584-587

The continuous monitoring of Parkinsons's disease (PD) symptoms would allow to automatically adjust medication or deep brain stimulation parameters to a patient's momentary condition. Wearable sensors have been proposed to monitor PD symptoms and have been validated in a number of lab and hospital settings. However, taking these sensors into the daily life of patients introduces a number of difficulties, most notably the absence of an observable ground truth of what the user is currently doing. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8857717DOI Listing

Implementation of New Technology in Patients with Chronic Deep Brain Stimulation: Switching from Non-Rechargeable Constant Voltage to Rechargeable Constant Current Stimulation.

Stereotact Funct Neurosurg 2019 16;97(5-6):362-368. Epub 2020 Jan 16.

Department of Neurology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Introduction: Deep brain stimulation (DBS) for movement disorders has been mainly performed with constant voltage (CV) technology. More recently also constant current (CC) systems have been developed which theoretically might have additional advantages. Furthermore, rechargeable (RC) system implantable pulse generators (IPG) are increasingly being used rather than the former solely available non-rechargeable (NRC) IPGs. Read More

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http://dx.doi.org/10.1159/000505076DOI Listing

Frameless Deep Brain Stimulation Surgery: A Single-Center Experience and Retrospective Analysis of Placement Accuracy of 220 Electrodes in a Series of 110 Patients.

Stereotact Funct Neurosurg 2019 14;97(5-6):337-346. Epub 2020 Jan 14.

Neurosurgery Unit, S. Maria della Misericordia University Hospital, Udine, Italy.

Background: Proper lead placement is considered one of the key factors in achieving a good clinical outcome in deep brain stimulation (DBS), but there is still considerable controversy surrounding the accuracy of the frameless in comparison to the frame-based technique.

Objective: We report our single-center experience with DBS electrode placement to evaluate the accuracy of the frameless stereotactic system.

Methods: We prospectively analyzed the data of 110 patients who underwent DBS surgery for Parkinson disease, dystonia, essential tremor, or refractory epilepsy. Read More

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http://dx.doi.org/10.1159/000503335DOI Listing

Treatment of Spinal Myoclonus Due to Degenerative Compression Myelopathy with Cervical Spinal Cord Stimulation: A Report of 2 Cases.

World Neurosurg 2020 Apr 7;136:44-48. Epub 2020 Jan 7.

Abteilung Wirbelsäulenchirurgie, Leopoldina Krankenhaus der Stadt Schweinfurt GmbH, Schweinfurt, Germany.

Background: Spinal myoclonus (SM) is a rare hyperkinetic movement disorder that is either idiopathic or secondary to spinal cord lesions. The treatment is either symptomatic only or addresses the underlying etiology. We describe 2 patients with SM with compression myelopathy who were treated with spinal cord stimulation (SCS). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.12.170DOI Listing

The role of tractography in the localization of the Vim nucleus of the thalamus and the dentato-rubro-thalamic tract for the treatment of tremor.

Neurologia 2020 Jan 6. Epub 2020 Jan 6.

Servicio de Neurocirugía, Clínica Universidad de Navarra, Pamplona, España. Electronic address:

Introduction: The ventralis intermedius (Vim) nucleus of the thalamus is the usual surgical target for tremor. However, locating the structure may be difficult as it is not visible with conventional imaging methods; therefore, surgical procedures typically use indirect calculations correlated with clinical and intraoperative neurophysiological findings. Current ablative surgical procedures such as Gamma-Knife thalamotomy and magnetic resonance-guided focused ultrasound require new alternatives for locating the Vim nucleus. Read More

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http://dx.doi.org/10.1016/j.nrl.2019.09.006DOI Listing
January 2020

[Advances in the development of otologic surgery robots].

Authors:
J Wang J Ke F R Ma

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Dec;54(12):944-948

Department of Otorhinolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing 100191, China.

In recent decades, surgical robots have made great progress and are widely used in many clinical departments.It can eliminate the doctor's hands tremor, reducing postoperative complications and shortening the operation time due to the many advantages of robot such as stability, high precision and intelligence. Based on the huge economic benefits and good performance, the surgical robots have become a hot spot in the field of medicine and industry. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.12.014DOI Listing
December 2019

Pediatric and adolescent gynecology: Treatment perspectives in minimally invasive surgery.

Pediatr Rep 2019 Dec 2;11(4):8029. Epub 2019 Dec 2.

Pediatric Unit, Department of Maternal and Children's Health, Fondazione IRCCS Policlinico San Matteo and Department of Internal Medicine, University of Pavia, Italy.

Minimally invasive surgery (MIS) is widely utilized across multiple surgical disciplines, including gynecology. To date, laparoscopy is considered a common surgical modality in children and adolescents to treat gynecological conditions. Robotic surgical devices were developed to circumvent the limitations of laparoscopy and have expanded the surgical armamentarium with better magnification, dexterity enhanced articulating instruments with 5-7 degrees of freedom, and ability to scale motion thus eliminating physiologic tremor. Read More

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http://dx.doi.org/10.4081/pr.2019.8029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908954PMC
December 2019

F-18 FDG PET brain imaging in symptomatic arthroprosthetic cobaltism.

Eur J Nucl Med Mol Imaging 2020 Jul 20;47(8):1961-1970. Epub 2019 Dec 20.

Aegis Imaging Consultants, LLC, P.O. Box 751, 170 Cervin Circle, Girdwood, AK, 99587, USA.

Purpose: Imaging studies of cobalt toxicity from cobalt-chromium alloy arthroprosthetics have focused on the local intra-articular and peri-articular presentation from failing joint replacements. Most studies investigating neurological findings have been small case series focused on the clinical findings of memory loss, diminished executive function, tremor, hearing and vision loss, depression, and emotional lability. This study utilizes software-based quantitative analysis of brain metabolism to assess the degree of hypometabolism and areas of susceptibility, determine if a pattern of involvement exists, and measure reversibility of findings after prosthetic revision to cobalt-free appliances. Read More

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http://dx.doi.org/10.1007/s00259-019-04648-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299907PMC

Laparoscopic Conversion of Roux-en-Y Gastric Bypass to Sleeve Gastrectomy for Postprandial Hyperinsulinemic Hypoglycemia.

Obes Surg 2020 Mar;30(3):1171-1172

Department of Surgery A, Emek Medical Center, 21 Izhak Rabin Blvd, 1834111, Afula, Israel.

Introduction: Roux-en-Y gastric bypass (RYGB) has proven to be a safe and effective treatment for obesity and its related comorbidities. However, RYGB may lead to uncommon, but occasionally difficult to treat complications such as postprandial hyperinsulinemic hypoglycemia (PHH) [1]. PHH is a condition characterized by hypoglycemic symptoms occurring 1-3 h after a meal, accompanied by low plasma glucose levels, typically preceded by a rise in both glucose and insulin concentrations [2]. Read More

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http://dx.doi.org/10.1007/s11695-019-04339-9DOI Listing
March 2020
3.747 Impact Factor

Deep brain stimulation: new possibilities for the treatment of mental disorders.

Psychiatr Pol 2019 Aug 31;53(4):789-806. Epub 2019 Aug 31.

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Katedra i Klinika Neurochirurgii.

Deep brain stimulation (DBS) is a treatment method that is currently getting more and more attention from psychiatrists. It has proven to be efficacious and safe in the treatment of neurological disorders, mainly Parkinson's disease (PD), dystonia and essential tremor. DBS has very often contributed to successful treatment in cases that had proved resistant to all other methods of treatment. Read More

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http://dx.doi.org/10.12740/PP/OnlineFirst/103090DOI Listing

Parkinson's disease: Diagnosis and appreciation of comorbidities.

Handb Clin Neurol 2019 ;167:257-277

Center for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida College of Medicine, Gainesville, FL, United States.

Parkinson's disease (PD) is a complex neuropsychiatric disorder that manifests with a variety of motor and nonmotor symptoms. Its incidence increases with age. It is important for clinicians to be able to distinguish symptoms of aging and other comorbidities from those of PD. Read More

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http://dx.doi.org/10.1016/B978-0-12-804766-8.00014-5DOI Listing

Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor.

Neurology 2019 12 20;93(24):e2284-e2293. Epub 2019 Nov 20.

From the Departments of Neurosurgery (C.H.H.), Neurology (V.S.), and Radiology (J.R., P.G.), Stanford University School of Medicine, CA; Department of Neurosurgery (N.L., A.M.L., M.L.S.), University of Toronto, Canada; Department of Neurology (B.B.S., W.J.E.), University of Virginia, Charlottesville; Departments of Neurosurgery (G.R.C.), Neurology (M.T.H.), and Radiology (N.M.), Brigham and Women's Hospital, Boston, MA; Departments of Neurosurgery (C.A., H.M.E.) and Radiology (D.G.), University of Maryland, Baltimore; Department of Neurosurgery (T.T.), Tokyo Women's Medical University, Japan; Departments of Neurosurgery (R.G.) and Neurology (S.R., J.W.), Swedish Hospital Seattle, WA; and Department of Neurosurgery (N.Y.J., J.W.C.), Yonsei University, Seoul, Republic of Korea.

Objective: To test the hypothesis that transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) thalamotomy is effective, durable, and safe for patients with medication-refractory essential tremor (ET), we assessed clinical outcomes at 3-year follow-up of a controlled multicenter prospective trial.

Methods: Outcomes were based on the Clinical Rating Scale for Tremor, including hand combined tremor-motor (scale of 0-32), functional disability (scale of 0-32), and postural tremor (scale of 0-4) scores, and total scores from the Quality of Life in Essential Tremor Questionnaire (scale of 0-100). Scores at 36 months were compared with baseline and at 6 months after treatment to assess for efficacy and durability. Read More

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http://dx.doi.org/10.1212/WNL.0000000000008561DOI Listing
December 2019
8.286 Impact Factor

Long-Term Suppression of Disabling Tremor by Thalamic Stimulation in a Patient with Spinocerebellar Ataxia Type 2.

Stereotact Funct Neurosurg 2019 19;97(4):241-243. Epub 2019 Nov 19.

Department of Neurology, Aizawa Hospital, Matsumoto, Japan,

The beneficial effect of thalamic deep brain stimulation (DBS) on action tremor has been reported in a few cases of spinocerebellar ataxia (SCA); however, several factors should be taken into account regarding the indication for DBS in advanced cases. We performed DBS of the ventral intermediate nucleus (Vim) of the thalamus for treatment of coarse action tremor in a patient with SCA2 (spinocerebellar ataxia type 2) in the wheelchair-bound stage. Although improvement of the tremor of the proximal part was incomplete, the patient regained substantial parts of daily functioning. Read More

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http://dx.doi.org/10.1159/000504062DOI Listing

Left Radiofrequency Thalamotomy for Drug-Refractory Essential Tremor.

World Neurosurg 2020 Feb 5;134:438. Epub 2019 Nov 5.

Department of Neurological Surgery, Mayo Clinic, Jacksonville, Florida, USA. Electronic address:

Essential tremor is an idiopathic movement disorder characterized by bilateral action tremor of the upper limbs with or without other neurologic symptoms. Pharmacologic management is the first-line treatment for this condition. Surgical treatment includes deep brain stimulation and thalamotomy procedures. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.10.180DOI Listing
February 2020

Femtosecond laser-assisted cataract surgery in a spherophakic lens: An unusual case report.

Medicine (Baltimore) 2019 Nov;98(44):e17426

Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX.

Rationale: Spherophakia is a rare diagnosis which is often associated with a shallow anterior chamber, angle-closure glaucoma, lens subluxation, and lenticular myopia. When cataracts occur with subluxation of the lens, vision is often markedly affected. This often presents surgeons with a unique challenge of maintaining good visual outcomes while minimizing potential complications. Read More

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http://dx.doi.org/10.1097/MD.0000000000017426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946445PMC
November 2019
5.723 Impact Factor

Altered Primary Motor Cortex Neuronal Activity in a Rat Model of Harmaline-Induced Tremor During Thalamic Deep Brain Stimulation.

Front Cell Neurosci 2019 15;13:448. Epub 2019 Oct 15.

Department of Neurologic Surgery, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States.

Although deep brain stimulation (DBS) is a clinically effective surgical treatment for essential tremor (ET), and its neurophysiological mechanisms are not fully understood. As the motor thalamus is the most popular DBS target for ET, and it is known that the thalamic nucleus plays a key role in relaying information about the external environment to the cerebral cortex, it is important to investigate mechanisms of thalamic DBS in the context of the cerebello-thalamo-cortical neuronal network. To examine this, we measured single-unit neuronal activities in the resting state in M1 during VL thalamic DBS in harmaline-induced tremor rats and analyzed neuronal activity patterns in the thalamo-cortical circuit. Read More

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http://dx.doi.org/10.3389/fncel.2019.00448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803555PMC
October 2019

Feasibility and Effectiveness of Direct Puncture and Onyx Embolization for Transverse Sinus Dural Arteriovenous Fistula.

Yonsei Med J 2019 Nov;60(11):1112-1115

Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.

Direct puncture and embolization of the transverse sinus (TS) for treatment of dural arteriovenous fistula (DAVF) is typically performed with coils with or without glue. We report a case of DAVF at the left TS that was treated with Onyx embolization via direct puncture of the TS. A 75-year-old woman presented with tremor, festinating gait, and dysarthria. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.11.1112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813141PMC
November 2019
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Infections in Deep Brain Stimulator Surgery.

Cureus 2019 Aug 20;11(8):e5440. Epub 2019 Aug 20.

Neurosurgery, Kaiser Permanente, Los Angeles, USA.

Introduction: Deep brain stimulation has emerged as an effective treatment for movement disorders such as Parkinson's disease, dystonia, and essential tremor with estimates of >100,000 deep brain stimulators (DBSs) implanted worldwide since 1980s. Infections rates vary widely in the literature with rates as high as 25%. Traditional management of infection after deep brain stimulation is systemic antibiotic therapy with wound incision and debridement (I&D) and removal of implanted DBS hardware. Read More

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http://dx.doi.org/10.7759/cureus.5440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797017PMC
August 2019
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Role of deep brain stimulation therapy in the magnetic resonance-guided high-frequency focused ultrasound era: current situation and future prospects.

Expert Rev Neurother 2020 Jan 22;20(1):7-21. Epub 2019 Oct 22.

Medicine Department, Universidad Complutense, Madrid, Spain.

: Deep brain stimulation (DBS) is a well-established treatment of movement disorders; but recently there has been an increasing trend toward the ablative procedure magnetic resonance-guided focused ultrasound (MRgFU). DBS is an efficient neuromodulatory technique but associated with surgical complications. MRIgFUS is an incision-free method that allows thermal lesioning, with fewer surgical complications but irreversible effects. Read More

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http://dx.doi.org/10.1080/14737175.2020.1677465DOI Listing
January 2020
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Apomorphine-induced reorganization of striato-frontal connectivity in patients with tremor-dominant Parkinson's disease.

Parkinsonism Relat Disord 2019 10 8;67:14-20. Epub 2019 Sep 8.

Institute of Molecular Bioimaging and Physiology, National Research Council, 88100, Catanzaro, Italy; Neuroscience Centre, University "Magna Graecia", 88100, Catanzaro, Italy. Electronic address:

Introduction: Apomorphine is a dopamine agonist used in Parkinson's disease (PD), which matches levodopa in terms of the magnitude of effect on the cardinal motor features, such as tremor and bradykinesia. The beneficial effect of this treatment on PD patients with tremor-dominant has widely been demonstrated, although the underlying neural correlates are unknown. We sought to examine the effects of apomorphine on topological characteristics of resting-state functional connectivity networks in tremor-dominant PD (tdPD) patients. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.09.006DOI Listing
October 2019
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Predicting high-intensity focused ultrasound thalamotomy lesions using 2D magnetic resonance thermometry and 3D Gaussian modeling.

Med Phys 2019 Dec 4;46(12):5722-5732. Epub 2019 Nov 4.

Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Purpose: To develop a method of using two-dimensional (2D) magnetic resonance thermometry, and three-dimensional (3D) Gaussian modeling to predict the volume, shape, and location of 1 day postoperative T1w high-intensity focused ultrasound lesions in medication refractory tremor patients; thereby facilitating a better comprehension of thermal damage thresholds, which can be utilized to reduce adverse events, and improve patient outcome.

Methods: Fifteen patients underwent magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy, which was performed at our center using an InSightec ExAblate 4000 system (Haifa, Israel), and guided by magnetic resonance imaging using a 3 T Discovery 750 (General Electric Healthcare, Waukesha, WI, USA). For treatment monitoring, 2D MR thermometry (temperature sensitivity: -0. Read More

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http://dx.doi.org/10.1002/mp.13868DOI Listing
December 2019

Posterior Subthalamic Area Deep Brain Stimulation for Treatment of Refractory Holmes Tremor.

Stereotact Funct Neurosurg 2019 10;97(3):183-188. Epub 2019 Oct 10.

Department of Neurology, Jagiellonian University, Medical College, Kraków, Poland.

Three right-handed patients diagnosed with Holmes tremor (HT), who suffered from pharmacotherapy-refractory tremor, were eligible for unilateral posterior subthalamic area deep brain stimulation (PSA-DBS). All patients were evaluated with the Fahn-Tolosa-Marin Tremor Rating Scale (FTMTRS) and Clinical Global Impression scale (CGI) before DBS, 6, and 12 months after the PSA-DBS as well as at the last follow-up. In all patients, we observed a significant improvement of tremor control as demonstrated by changes in the FTMTRS and the CGI scales. Read More

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http://dx.doi.org/10.1159/000502563DOI Listing
February 2020
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Is Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound a Repeatable Treatment Option? Case Report of a Retreated Patient With Tremor Combined With Parkinsonism.

Oper Neurosurg (Hagerstown) 2020 Jun;18(6):577-582

Section of Radiological Sciences, Department of Biomedicine, Neurosciences & Advanced Diagnostics, University of Palermo, Palermo, Italy.

Introduction: In recent years, transcranial Magnetic Resonance Imaging-guided Focused Ultrasound (tcMRgFUS) treatments for functional neurological disorders are giving a new thrust to the field of therapeutic brain lesioning.

Objective: To present the case of a patient affected by tremor combined with Parkinsonism who underwent a second tcMRgFUS thalamotomy because of relapsing tremor after a few months from the first tcMRgFUS treatment.

Methods: A 72-yr-old, right-handed man, came to our observation because of a disabling tremor affecting his upper limbs, refusing any invasive surgical procedure and already treated by tcMRgFUS left Vim thalamotomy. Read More

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http://dx.doi.org/10.1093/ons/opz300DOI Listing
June 2020
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Deep Brain Stimulation in Movement Disorders: From Experimental Surgery to Evidence-Based Therapy.

Mov Disord 2019 12 3;34(12):1795-1810. Epub 2019 Oct 3.

Department of Neurology, University Hospital Schleswig Holstein (UKSH), Kiel Campus; Christian-Albrechts-University Kiel, Germany.

Deep brain stimulation (DBS) of 3 different targets is the most important therapeutic innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD), disabling dystonia, tremors, and refractory Gilles de la Tourette syndrome. When compared with medical treatment alone, controlled studies have shown better motor, nonmotor, and particularly quality-of-life outcomes with large effect sizes for advanced complicated PD that cannot be improved with medication, and also for PD patients with only early fluctuations. Class 1 studies have also shown superiority over medical treatment for generalized, segmental, and botulinum-toxin refractory focal cervical dystonia. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mds.27860
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http://dx.doi.org/10.1002/mds.27860DOI Listing
December 2019
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Treatment of essential tremor: current status.

Postgrad Med J 2020 Feb 1;96(1132):84-93. Epub 2019 Oct 1.

Neurology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India

Essential tremor is the most common cause of tremor involving upper limbs, head and voice. The first line of treatment for limb tremor is pharmacotherapy with propranolol or primidone. However, these two drugs reduce the tremor severity by only half. Read More

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http://dx.doi.org/10.1136/postgradmedj-2019-136647DOI Listing
February 2020
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Comparison of Parkinson's Disease Patients' Characteristics by Indication for Deep Brain Stimulation: Men Are More Likely to Have DBS for Tremor.

Tremor Other Hyperkinet Mov (N Y) 2019 17;9. Epub 2019 Sep 17.

Department of Neurology, University of Virginia, Charlottesville, VA, USA.

Background: We investigated whether the characteristics of Parkinson's disease (PD) patients differ based on the primary indication for deep brain stimulation (DBS).

Methods: We reviewed data for 149 consecutive PD patients who underwent DBS at the University of Virginia. Patients were categorized based on primary surgical indication, and clinical characteristics were compared between groups. Read More

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http://dx.doi.org/10.7916/tohm.v0.676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749750PMC
March 2020
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Traditional Trial and Error versus Neuroanatomic 3-Dimensional Image Software-Assisted Deep Brain Stimulation Programming in Patients with Parkinson Disease.

World Neurosurg 2020 Feb 27;134:e98-e102. Epub 2019 Sep 27.

Division of Brain Sciences, Imperial College London, London, United Kingdom.

Background: Programming deep brain stimulation (DBS) settings in patients with Parkinson disease (PD) is challenging and time consuming because of the vast number of possible parameter combinations. This results in long sessions that can be exhausting for the patients and physicians. GUIDE (Boston Scientific) is a 3-dimensional neuroanatomic visual software that precisely visualizes the location of the DBS electrode in the subthalamic nucleus (STN). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.09.106DOI Listing
February 2020
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2.417 Impact Factor

Changes in Midline Tremor and Gait Following Deep Brain Stimulation for Essential Tremor.

Tremor Other Hyperkinet Mov (N Y) 2019 11;9. Epub 2019 Sep 11.

Program for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA.

Background: Essential tremor (ET) is a common movement disorder characterized by kinetic and postural tremor in the upper extremities and frequently in the midline. Persons with ET often also exhibit gait ataxia. Previous studies have observed associations between midline tremor severity and gait ataxia in persons with ET, suggesting a common pathophysiology distinct from that of upper extremity tremor. Read More

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http://dx.doi.org/10.7916/tohm.v0.684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744814PMC

Dorsal GPi/GPe Stimulation Induced Dyskinesia in a Patient with Parkinson's Disease.

Tremor Other Hyperkinet Mov (N Y) 2019 6;9. Epub 2019 Sep 6.

Fixel Institute for Neurological Diseases, Gainesville, FL, USA.

Clinical Vignette: A 68-year-old man with Parkinson's disease (PD) had bilateral GPi DBS placed for management of his motor fluctuations. He developed stimulation-induced dyskinesia (SID) with left dorsal GPi stimulation.

Clinical Dilemma: What do we know about SID in PD patients with GPi DBS? What are the potential strategies used to maximize the DBS therapeutic benefit and minimize the side effects of stimulation?

Clinical Solution: Avoiding the contact implicated in SID and programming more ventral contacts, using lower voltage, frequency and pulse width and programming in bipolar configuration all appear to help minimize the SID and provide appropriate symptomatic motor control. Read More

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http://dx.doi.org/10.7916/tohm.v0.685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744811PMC
March 2020
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