3,674 results match your criteria Surgical Treatment of Tremor

Coherent Structural and Functional Network Changes after Thalamic Lesions in Essential Tremor.

Mov Disord 2022 Jun 23. Epub 2022 Jun 23.

Division "Clinical Functional Imaging," Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany.

Background: Magnetic resonance-guided focused ultrasound of the ventral intermediate nucleus is a novel incisionless ablative treatment for essential tremor (ET).

Objective: The aim was to study the structural and functional network changes induced by unilateral sonication of the ventral intermediate nucleus in ET.

Methods: Fifteen essential tremor patients (66. Read More

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Evolving Concepts in Our Understanding and Treatment of Holmes Tremor, Over 100 Years in the Making.

Tremor Other Hyperkinet Mov (N Y) 2022 26;12:18. Epub 2022 May 26.

Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, US.

Holmes Tremor (HT) is an irregular, slow-frequency (<4.5 Hz) tremor characterized by a combination of resting, postural, and action tremors mostly of the upper extremities. Symptoms of HT typically emerge 4 weeks to 2 years after a brain injury caused by a spectrum of etiologies. Read More

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An Admittance-Controlled Amplified Force Tracking Scheme for Collaborative Lumbar Puncture Surgical Robot System.

Int J Med Robot 2022 Jun 1:e2428. Epub 2022 Jun 1.

Higher Institute of Information Technology and Information Systems, Kazan, Russian Federation.

Background: The accurate sensing and display of the delicate needle-tissue interaction force to the operator is desirable for needle insertion procedures. It not only plays a significant role in the surgical treatment effect, but also has a great significance in improving surgical safety and reducing the incidence of complications. However, the direct detection of the interaction force between the tissue and needle tip by placement of a force sensor is challenging owing to the constraints of miniaturization, cost, and sterilization. Read More

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Movement Disorders in Multiple Sclerosis: An Update.

Tremor Other Hyperkinet Mov (N Y) 2022 4;12:14. Epub 2022 May 4.

Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.

Background: Multiple sclerosis (MS), a subset of chronic primary inflammatory demyelinating disorders of the central nervous system, is closely associated with various movement disorders. These disorders may be due to MS pathophysiology or be coincidental. This review describes the full spectrum of movement disorders in MS with their possible mechanistic pathways and therapeutic modalities. Read More

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Effect of virtual reality rehabilitation on functional outcomes for return-to-work patients with Parkinson's disease: An umbrella review of systematic reviews.

NeuroRehabilitation 2022 May 18. Epub 2022 May 18.

Department of Medical, Oral and Biotechnological Sciences, Unit of Physical and Rehabilitation Medicine, G. D'Annunzio University of Chieti-Pescara, Chieti, Italy.

Background: Parkinson's disease (PD) is a neurodegenerative disease characterized by loss of substantia nigra neurons with deficiency of dopamine. The main symptoms are tremor, rigidity and bradykinesia. Rehabilitation has an important role in the treatment of this condition and virtual reality (VR) is one of the most recent tools. Read More

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[Essential Tremor That is Difficult to Improve with Standard Medical Treatment-Suppression: Surgical Treatment of Tremor].

Brain Nerve 2022 May;74(5):645-651

Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences.

Drug-refractory essential tremors, especially those in the upper extremities, may benefit from surgical treatment. Currently, three main treatment methods are available: deep brain stimulation (DBS), radiofrequency coagulation (RF), and magnetic resonance -guided focused ultrasound surgery (MRgFUS). DBS is a device-based therapy, and its effects are reversible, whereas RF and FUS create irreversible coagulation lesions. Read More

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[Essential Tremor That is Difficult to Improve with Standard Medical Treatment-Suppression: Excluding Surgical Treatment].

Brain Nerve 2022 May;74(5):637-644

Hiroshima Teishin Hospital.

For essential tremors that are refractory to standard medical treatment, surgical treatment is considered when there is obstruction in activities of daily living. However, there are patients who do not wish to undergo or are contraindicated for surgical treatment. In this paper, we explored what is considered to be the standard medical treatment and when surgery cannot be performed. Read More

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Milestones in Tremor Research: 10 Years Later.

Mov Disord Clin Pract 2022 May 26;9(4):429-435. Epub 2022 Feb 26.

Department of Clinical and Movement Neurosciences University College London London United Kingdom.

Major progress has occurred during the last decade in the field of tremor. From the clinical standpoint, a new classification has completely revised the nosology of tremor syndromes and has re-conceptualized essential tremor as a syndrome rather than a single disease entity, fueling an ongoing enlightened debate. Significant advances have been obtained in terms of instrumental measurement of tremor, remarking on the possibility of developing novel treatment strategies based on tremor characteristics, namely tremor-phase. Read More

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Short pulse and directional thalamic deep brain stimulation have differential effects in parkinsonian and essential tremor.

Sci Rep 2022 05 4;12(1):7251. Epub 2022 May 4.

Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

The aim of this study was to assess the effects of novel stimulation algorithms of deep brain stimulation (short pulse and directional stimulation) in the ventrointermediate thalamus and posterior subthalamic area (VIM/PSA-DBS) on tremor in Parkinson's disease (PD) and to compare the effects with those in essential tremor (ET). We recruited six PD patients (70.8 ± 10. Read More

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Evaluation of DBS Timeline in Movement Disorders: A Comparison Between Genders.

World Neurosurg 2022 Apr 28. Epub 2022 Apr 28.

Division of Neurosurgery, Spectrum Health, Grand Rapids, Michigan, USA.

Background: Deep brain stimulation (DBS) is a pivotal surgical treatment for movement disorders. However, men and women have had differing opinions and referral experiences related to DBS, leading us to assess whether a gender disparity exists in the interval from a movement disorder diagnosis to DBS usage.

Methods: We performed a single-center, retrospective cohort study of 105 patients who had undergone DBS surgery for either Parkinson disease (PD) or essential tremor (ET). Read More

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Directional stimulation improves stimulation-induced dysgeusia in DBS for essential tremor.

Brain Stimul 2022 May-Jun;15(3):680-682. Epub 2022 Apr 26.

Department of Neurology and Clinical Neurophysiology, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, the Netherlands.

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Therapeutic Devices for Motor Symptoms in Parkinson's Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials.

Front Aging Neurosci 2022 29;14:807909. Epub 2022 Mar 29.

Department of Advanced Brain Research, Institute of Biomedical Sciences, Graduate School of Medicine, Tokushima University, Tokushima, Japan.

Background: Pharmacotherapy is the first-line treatment option for Parkinson's disease, and levodopa is considered the most effective drug for managing motor symptoms. However, side effects such as motor fluctuation and dyskinesia have been associated with levodopa treatment. For these conditions, alternative therapies, including invasive and non-invasive medical devices, may be helpful. Read More

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Botulinum Toxin Therapy for Oromandibular Dystonia and Other Movement Disorders in the Stomatognathic System.

Kazuya Yoshida

Toxins (Basel) 2022 04 14;14(4). Epub 2022 Apr 14.

Department of Oral and Maxillofacial Surgery, National Hospital Organization, Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto 612-8555, Japan.

Various movement disorders, such as oromandibular dystonia, oral dyskinesia, bruxism, functional (psychogenic) movement disorder, and tremors, exist in the stomatognathic system. Most patients experiencing involuntary movements due to these disorders visit dentists or oral surgeons, who may be the first healthcare providers. However, differential diagnoses require neurological and dental knowledge. Read More

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Probing responses to deep brain stimulation with functional magnetic resonance imaging.

Brain Stimul 2022 May-Jun;15(3):683-694. Epub 2022 Apr 18.

Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Canada; Krembil Research Institute, Toronto, Ontario, Canada. Electronic address:

Background: Deep brain stimulation (DBS) is an established treatment for certain movement disorders and has additionally shown promise for various psychiatric, cognitive, and seizure disorders. However, the mechanisms through which stimulation exerts therapeutic effects are incompletely understood. A technique that may help to address this knowledge gap is functional magnetic resonance imaging (fMRI). Read More

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Vim-Thalamic Deep Brain Stimulation for Cervical Dystonia and Upper-Limb Tremor: Quantification by Markerless-3D Kinematics and Accelerometry.

Tremor Other Hyperkinet Mov (N Y) 2022 10;12. Epub 2022 Mar 10.

Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, US.

Background: Deep Brain Stimulation (DBS) for dystonia is usually targeted to the globus pallidus internus (GPi), though stimulation of the ventral-intermediate nucleus of the thalamus (Vim) can be an effective treatment for phasic components of dystonia including tremor. We report on a patient who developed a syndrome of bilateral upper limb postural and action tremor and progressive cervical dystonia with both phasic and tonic components which were responsive to Vim DBS. We characterize and quantify this effect using markerless-3D-kinematics combined with accelerometry. Read More

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Changes in elbow flexion EMG morphology during adjustment of deep brain stimulator in advanced Parkinson's disease.

PLoS One 2022 14;17(4):e0266936. Epub 2022 Apr 14.

Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.

Objective: Deep brain stimulation (DBS) is an effective treatment for motor symptoms of advanced Parkinson's disease (PD). Currently, DBS programming outcome is based on a clinical assessment. In an optimal situation, an objectively measurable feature would assist the operator to select the appropriate settings for DBS. Read More

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Analysis of human brain tissue derived from DBS surgery.

Transl Neurodegener 2022 04 13;11(1):22. Epub 2022 Apr 13.

PEDEGO Research Unit, University of Oulu, Oulu, Finland.

Background: Transcriptomic and proteomic profiling of human brain tissue is hindered by the availability of fresh samples from living patients. Postmortem samples usually represent the advanced disease stage of the patient. Furthermore, the postmortem interval can affect the transcriptomic and proteomic profiles. Read More

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Anaesthetic Management of a Labrador Retriever Undergoing Adrenalectomy for Phaeochromocytoma Excision, a Case Report.

Front Vet Sci 2022 16;9:789101. Epub 2022 Mar 16.

Anaesthesiology and Pain Therapy Division, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Perioperative management of cases undergoing phaeochromocytoma removal should aim at normalising blood pressure and heart rate, restoring volume depletion, and preventing catecholamine release induced by surgical manipulation. In this case report, a novel pharmacological approach in a dog undergoing surgical tumour excision is described. A 7-year-old 25-kg spayed female Labrador Retriever presented for repeated episodes of generalised weakness, pale mucous membranes, tachycardia, tremor, panting, vomiting, and hypertension over the last month was referred for surgical treatment of a left-sided adrenal tumour with invasion of the caudal vena cava. Read More

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Converging on a Neuromodulation Target for Tremor.

Ann Neurol 2022 05 8;91(5):581-584. Epub 2022 Apr 8.

Department of Neurology, UKSH, Christian-Albrechts-University Kiel, Kiel, Germany.

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DBS, tcMRgFUS, and Gamma Knife radiosurgery for the treatment of essential tremor: a systematic review on techniques, indications, and current applications.

J Neurosurg Sci 2022 Mar 17. Epub 2022 Mar 17.

Unit of Neurosurgery, Post-graduate Residency Programme in Neurological surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, Palermo, Italy.

Introduction: Essential tremor (ET) may severely impact patient's quality of life. Several techniques such as radiofrequency, Deep Brain Stimulation (DBS), Gamma Knife (GK) radiosurgery and high-intensity focused ultrasound may be used for the surgical treatment of ET. The aim of this paper is to summarize the most recent available literature on DBS, transcranial Magnetic Resonance-guided Focused Ultrasound (tcMRgFUS) and GK, and to compare indications, targets, and effectiveness of these surgical techniques for the treatment of ET. Read More

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Deep brain stimulation for the treatment of tremor.

J Neurol Sci 2022 04 4;435:120190. Epub 2022 Mar 4.

University of Florida, Department of Neurological Surgery, USA; Norman Fixel Institute for Neurological Diseases at UF Health, USA. Electronic address:

This review article provides a brief historical perspective on the use of DBS for tremor, reviews the various etiologies for tremor that can be effectively managed with DBS therapy, discusses the DBS targets that have been used for suppression of tremor, and reviews in detail important aspects of DBS surgical technique, including significant technological advances over the past several years that, when applied, can substantially improve the outcomes of DBS for tremor. This article is part of the Special Issue "Tremor" edited by Daniel D. Truong, Mark Hallett, and Aasef Shaikh. Read More

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Laparoscopic Training for Gastrointestinal Surgery Using Japanese Traditional Papercraft Origami.

Surg Laparosc Endosc Percutan Tech 2022 Jun 1;32(3):401-403. Epub 2022 Jun 1.

Department of Surgery, Japanese Red Cross Society Karatsu Red Cross Hospital, Karatsu, Saga Prefecture, Japan.

Purpose: The aim of this study is to show the experience and results of laparoscopic training using origami, a Japanese traditional papercraft, and to discuss its usefulness in gastrointestinal surgery.

Materials And Methods: A laparoscopic training dry box was used. An origami paper crane was folded using laparoscopic instruments. Read More

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Deep brain stimulation for atypical parkinsonism: A systematic review on efficacy and safety.

Parkinsonism Relat Disord 2022 03 9;96:109-118. Epub 2022 Mar 9.

Department of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco 15, 10126, Torino, Italy; Neurology 2 Unit, A.O.U, Città della Salute e della Scienza di Torino, Corso Bramante 88, 10126, Torino, Italy.

Background: Atypical Parkinsonisms (APs) -including progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB)- are neurodegenerative diseases lacking satisfying symptomatic therapies. Deep Brain Stimulation (DBS) is an established neurosurgical option for advanced Parkinson disease (PD). Although DBS effectiveness in PD fed expectations for the treatment of APs, DBS is still not recommended for APs on the basis of expert consensus and lack of clinical trials. Read More

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Focused ultrasound and other lesioning in the treatment of tremor.

J Neurol Sci 2022 04 19;435:120193. Epub 2022 Feb 19.

Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA.

There has been a long history of lesioning procedures to treat tremor associated with both essential tremor (ET) and Parkinson's disease (PD). These include radiofrequency (RF) thalamotomy, gamma knife radiosurgical (GKRS) thalamotomy, and magnetic resonance-guided focused ultrasound (MRgFUS). In this review, we summarize the clinical studies of lesioning procedures for tremor focusing on these ablative therapies for ET and tremor-predominant PD (TDPD). Read More

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Essential Tremor-Do We Have Better Therapeutics? A Review of Recent Advances and Future Directions.

Neil Shetty

Curr Neurol Neurosci Rep 2022 03 2;22(3):197-208. Epub 2022 Mar 2.

Parkinson's Disease and Movement Disorders Center, Department of Neurology, Northwestern University Feinberg School of Medicine, Abbott Hall, 11th Floor, 710 N. Lake Shore Drive, Chicago, IL, 60611, USA.

Purpose Of Review: Essential tremor (ET) is a very common condition that significantly impacts quality of life. Current medical treatments are quite limited, and while surgical treatments like deep brain stimulation (DBS) can be very effective, they come with their own limitations as well as procedural risks. This article reviews updates on recent advances and future directions in the treatment of ET. Read More

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Effect of Public Interest in Magnetic Resonance Imaging-Guided Focused Ultrasound on Enrolment for Deep Brain Stimulation.

Mov Disord 2022 May 2;37(5):1103-1104. Epub 2022 Mar 2.

Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.

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Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer.

J Vis Exp 2022 02 12(180). Epub 2022 Feb 12.

Department of General Surgery, The First Affiliated Hospital of Xian Jiaotong University; Center for Gut Microbiome Research, Med-X Institute, The First Affiliated Hospital of Xian Jiao tong University; Department of High Talent, The First Affiliated Hospital of Xian Jiaotong University;

Since their approval for clinical use, da Vinci surgical robots have shown great advantages in gastrointestinal surgical operations, especially in complex procedures. The high-quality 3-D visual, multijoint arm and natural tremor filtration allow the surgeon to expose and dissect more accurately with minimal invasion. Total mesorectal excision is the standard surgical technique for the treatment of resectable rectal cancer. Read More

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February 2022

Non-invasive electrical stimulation of peripheral nerves for the management of tremor.

J Neurol Sci 2022 04 19;435:120195. Epub 2022 Feb 19.

Stanford University, Stanford, CA, USA.

Pathological tremor in patients with essential tremor and Parkinsons disease is typically treated using medication or neurosurgical interventions. There is a widely recognized need for new treatments that avoid the side effects of current medications and do not carry the risks of surgical interventions. Building on decades of research and engineering development, non-invasive electrical stimulation of peripheral nerves has emerged as a safe and effective strategy for reducing pathologic tremor in essential tremor. Read More

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Vestibular Disorders after Kidney Transplantation: Focus on the Pathophysiological Mechanisms Underlying the Vertical Nystagmus Associated with Tacrolimus-Related Hypomagnesamia.

Int J Environ Res Public Health 2022 02 16;19(4). Epub 2022 Feb 16.

Unit of Audiology, Department of Experimental and Clinical Medicine, Regional Centre of Cochlear Implants and ENT Diseases, Magna Graecia University, 88100 Catanzaro, Italy.

The purpose of this paper is to present the case of a patient undergoing kidney transplantation who developed limb tremor dizziness and vertical nystagmus (ny) during Tacrolimus (TAC) therapy and to investigate the pathophysiological mechanisms underlying the balance disorder. This case study regards a 51-year old kidney transplant male patient with hand tremors and lower limbs asthenia associated with dizziness and nausea. The symptoms started two months after the beginning of intravenous TAC for renal transplantation. Read More

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February 2022

Pretherapeutic functional connectivity of tractography-based targeting of the ventral intermediate nucleus for predicting tremor response in patients with Parkinson's disease after thalamotomy with MRI-guided focused ultrasound.

J Neurosurg 2022 Feb 18:1-10. Epub 2022 Feb 18.

1Department of Radiology, Chinese PLA General Hospital/Chinese PLA Medical School, Beijing, China; and.

Objective: Tractography-based direct targeting of the ventral intermediate nucleus (T-VIM) is a novel method that provides patient-specific VIM coordinates. This study aimed to explore the accuracy and predictive value of using T-VIM in combination with tractography and resting-state functional connectivity techniques to perform magnetic resonance imaging-guided focused ultrasound (MRgFUS) thalamotomy as a treatment of Parkinson's disease (PD).

Methods: PD patients underwent MRgFUS thalamotomy and were recruited for functional MRI scanning. Read More

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February 2022