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Prog Brain Res 2019 2;245:201-246. Epub 2019 Apr 2.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address:

Parkinson's disease (PD) is affecting >10 million people worldwide for which no suitable cure has been developed so far. Roughly, about two people per thousand populations are affected with PD like symptoms especially over the age of 50. About 1% of the populations above 60 years suffer from PD-like disease. Read More

J Neurol Sci 2019 May 14;400:97-103. Epub 2019 Mar 14.

Department of Neurosurgery, Bródno Mazovia Hospital, Warsaw, Poland, Kondratowicza 8 Street, 03-242 Warsaw, Poland.

Background: We present our operative experience of patients with movement disorders who developed intracerebral hemorrhage (ICH), which was identified on intraprocedural stereotactic computed tomography (CT) imaging performed immediately after deep brain stimulation (DBS) lead placement and prior to the implantation of further components of the DBS hardware.

Methods: Patients who underwent DBS lead implantation from January 2009 through December 2017 were included in the present study. Most of the surgeries were performed in a staged fashion. Read More

Brain Stimul 2019 Mar 7. Epub 2019 Mar 7.

Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, PR China. Electronic address:

Background: Deep brain stimulation (DBS) is a well-established surgical therapy for Parkinson's disease (PD). Intraoperative imaging (IMG), intraoperative physiology (PHY) and their combination (COMB) are the three mainstream DBS guidance methods.

Objective: To comprehensively compare the use of IMG-DBS, PHY-DBS and COMB-DBS in treating PD. Read More

Neurol Clin Pract 2019 Feb;9(1):74-82

Department of Neurology, Nara Medical University, Nara Medical University, Kashihara, Nara, Japan.

Purpose Of Review: Understanding the pathophysiologic underpinnings of lateral trunk flexion (LTF) in Parkinson disease (PD) has been growing. Adjusting antiparkinsonian medications, botulinum toxin, or surgical intervention has been found efficacious in some patients. Nevertheless, these treatments remain limited, often resulting in inadequate outcomes. Read More

Parkinsonism Relat Disord 2019 Mar 2. Epub 2019 Mar 2.

James Parkinson Unit, Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.

Spinal cord stimulation (SCS) is an effective surgical therapy used for the treatment of chronic neuropathic pain. Tonic SCS is safe and improve not only gait disorders, motor symptoms, but also quality of life in Parkinson patients even with dopa-resistant symptoms with or without associated deep brain stimulation. Read More

Clin Neurol Neurosurg 2019 Apr 21;179:67-73. Epub 2019 Feb 21.

Ochsner Clinic Foundation, Department of Neurosurgery, New Orleans, LA, USA; Tulane Medical Center, Department of Neurosurgery, New Orleans, LA, USA.

Objectives: Deep brain stimulation (DBS) is the surgical treatment of choice for moderate to severe Parkinson's Disease (PD). However, few studies have assessed its efficacy in severe PD as defined by the modified Hoehn and Yahr scale (HY). This study evaluates long-term and medication outcomes of DBS in severe PD. Read More

Neuromodulation 2019 Mar 7. Epub 2019 Mar 7.

Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.

Objective: Although deep brain stimulation (DBS) is an effective treatment for movement disorders, improvement varies substantially in individuals, across clinical trials, and over time. Noninvasive biomarkers that predict the individual response to DBS could be used to optimize outcomes and drive technological innovation in neuromodulation. We sought to evaluate whether noninvasive event related potentials elicited by subthalamic DBS during surgical targeting predict the tolerability of a given stimulation site in patients with advanced Parkinson's disease. Read More

Neurosurgery 2019 Mar 6. Epub 2019 Mar 6.

Department of Neurosurgery, Julius-Maximilians-University Hospital, Wue-rzburg, Germany.

Background: Clinical trials have established subthalamic deep-brain-stimulation (STN-DBS) as a highly effective treatment for motor symptoms of Parkinson disease (PD), but in clinical practice outcomes are variable. Experienced centers are confronted with an increasing number of patients with partially "failed" STN-DBS, in whom motor benefit doesn't meet expectations. These patients require a complex multidisciplinary and standardized workup to identify the likely cause. Read More

Value Health 2019 02 31;22(2):254-262. Epub 2018 Aug 31.

Adelaide Medical School, Faculty of Health Sciences, The University of Adelaide, SAHMRI, South Australia, Australia; The Queen Elizabeth Hospital, Woodville South, South Australia, Australia; CALHN, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Objectives: To examine economic evaluation studies of stem cell therapies (SCTs) in neurological disorders and to provide an overview of the quality of the economic evidence available on this topic.

Methods: The review examined studies that performed an economic evaluation of the use of stem cells in adult patients with neurological diseases and that were published in English during the period 2007 to 2017. Data analyzed and reported included study population, disease indication, main analytical approaches for the economic analysis and perspective, key assumptions made or tested in sensitivity analyses, cost outcomes, estimates of incremental cost effectiveness, and approaches to quantifying decision uncertainty. Read More

Med Clin North Am 2019 Mar;103(2):351-356

Department of Neurology, University of Maryland School of Medicine, 110 South Paca Street, 3rd Floor, Baltimore, MD 21201, USA. Electronic address:

Essential tremor is one of the most common movement disorders. It is characterized by a bilateral action tremor of the upper limbs. It may be accompanied by tremor of the head, voice, or lower limbs. Read More

Med Clin North Am 2019 Mar 3;103(2):337-350. Epub 2018 Dec 3.

Department of Neurology, University of Maryland School of Medicine, 110 South Paca Street, 3rd Floor, Baltimore, MD 21201, USA.

The diagnosis of Parkinson disease (PD) is based on the presence of bradykinesia and either resting tremor or rigidity and there should be no features from the history or examination to suggest an alternative cause of parkinsonism. In addition to the motor manifestations of PD, there is a long list of nonmotor symptoms, several of which occur before motor signs and are considered "prodromal" PD. These are classified as neuropsychiatric, autonomic, sleep, and sensory. Read More

Neurosurgery 2019 Jan 23. Epub 2019 Jan 23.

Department of Neurosurgery, Instituto de Investigación Sanitaria San Carlos, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain.

Background: Although deep brain stimulation (DBS) of the dorsolateral subthalamic nucleus (STN) is a well-established surgical treatment for patients with Parkinson disease (PD), there is still controversy about the relationship between the functional segregation of the STN and clinical outcomes.

Objective: To correlate motor and neuropsychological (NPS) outcomes with the overlap between the volume of activated tissue (VAT) and the tractography-defined regions within the STN.

Methods: Retrospective study evaluating 13 patients with PD treated with STN-DBS. Read More

Neuropsychology 2019 Feb 21;33(2):178-194. Epub 2019 Jan 21.

University of Geneva.

Objective: Deep brain stimulation (DBS) has become a well-established treatment that significantly improves the motor symptoms of Parkinson's disease (PD). Patients may nevertheless experience psychosocial maladjustment after surgery, as reported by an increasing body of research. Yet, no comprehensive theoretical approach has been proposed to account for this. Read More

Parkinsonism Relat Disord 2019 Jan 3. Epub 2019 Jan 3.

Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Significant advances in the symptomatic treatment of Parkinson disease (PD) have occurred since the discovery of levodopa (LD). Perhaps as a testament to its unparalleled efficacy, novel formulations aiming to optimize LD delivery to obtain better bioavailability, longer duration of effect and less plasma level fluctuations remain a major focus of drug development, nearly 5 decades since it was first commercially used. In addition, alternative apomorphine delivery formulations are also in development to provide rapid-acting, needle-free agents for the management of "off" episodes in patients experiencing motor fluctuations. Read More

World Neurosurg 2019 Jan 14. Epub 2019 Jan 14.

Section of Neurosurgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Background: In the coming years the number of patients with cognitive disorders, such as Alzheimer disease and traumatic brain injury, is expected to dramatically increase, leading to an ever-increasing societal cost. Unfortunately, few medical and pharmacologic treatments have shown tangible benefit in the treatment of these diseases. Deep brain stimulation (DBS) is an established surgical technique to address multiple conditions, including Parkinson disease and essential tremor. Read More

Mov Disord 2019 Feb 17;34(2):180-198. Epub 2019 Jan 17.

CHDI Management/CHDI Foundation, Princeton, NJ, USA.

Objective: To update evidence-based medicine recommendations for treating nonmotor symptoms in Parkinson's disease (PD).

Background: The International Parkinson and Movement Disorder Society Evidence-Based Medicine Committee's recommendations for treatments of PD were first published in 2002, updated in 2011, and now updated again through December 31, 2016.

Methods: Level I studies testing pharmacological, surgical, or nonpharmacological interventions for the treatment of nonmotor symptoms in PD were reviewed. Read More

Stereotact Funct Neurosurg 2018 16;96(6):353-363. Epub 2019 Jan 16.

Department of Neurology, Inselspital, University Hospital Bern, Bern, Switzerland.

Before the advent of levodopa, pallidotomy was initially the most effective treatment for Parkinson disease, but it was soon superseded by thalamotomy. It is widely unknown that, similar to Leksell, 2 neurologists from Göttingen, Orthner and Roeder, perpetuated pallidotomy against the mainstream of their time. Postmortem studies demonstrated that true posterior and ventral pallidoansotomy sparing the overwhelming mass of the pallidum was accomplished. Read More

Turk Neurosurg 2019 ;29(2):194-204

Neurosurgical Department of Postgraduate Medical Center, Warsaw, Poland.

Aim: To assess the health-related quality of life (HRQoL) with the Parkinson"s Disease Questionnaire 39 (PDQ-39) after unilateral subthalamic deep brain stimulation (STN DBS) and to identify correlations between the changes in UPDRS (Unified Parkinson"s Disease Rating Scale) scores and separate PDQ-39 QoL dimensions and PDQ summary index (SI) score at short-term follow-up (FU1) and long-term follow-up (FU2).

Material And Methods: We evaluated 33 patients with PD after unilateral STN DBS. All patients were assessed at baseline and at FU1 and at FU2. Read More

Mov Disord Clin Pract 2018 Nov-Dec;5(6):586-596. Epub 2018 Oct 9.

Parkinson's Disease Research Clinic, Brain and Mind Centre University of Sydney Sydney NSW Australia.

Background: Parkinson's disease (PD) is the second-most common neurodegenerative disorder after Alzheimer's disease; however, to date, there is no approved treatment that stops or slows down disease progression. Over the past decades, neuroimaging studies, including molecular imaging and MRI are trying to provide insights into the mechanisms underlying PD.

Methods: This work utilized a literature review. Read More

eNeuro 2018 Nov-Dec;5(6). Epub 2018 Dec 21.

Department of Neurosurgery, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.

The β-band oscillation in the subthalamic nucleus (STN) is a therapeutic target for Parkinson's disease. Previous studies demonstrated that l-DOPA decreases the β-band (13-30 Hz) oscillations with improvement of motor symptoms. However, it has not been elucidated whether patients with Parkinson's disease are able to control the β-band oscillation voluntarily. Read More

Int J Med Inform 2019 Feb 26;122:45-54. Epub 2018 Nov 26.

Department of Surgical and Medical Science, Magna Graecia University, 88100 Catanzaro, Italy. Electronic address:

Background And Objective: Neurodegenerative diseases are disorders that affect neurons in the brain resulting in a debilitating condition and progressive degeneration of nerve cells. These diseases involve different aspects among which speech impairment. Vocal signal analysis is used to evaluate this impairment and to discriminate normal from pathological voices. Read More

World Neurosurg 2019 Mar 18;123:197-207. Epub 2018 Dec 18.

Department of Neurosurgery, The University of Toledo Medical Center, Toledo, Ohio, USA.

Background: Parkinson disease (PD) remains a common neurodegenerative disorder. Functional neurosurgery largely arose with the introduction of deep brain stimulation (DBS) as a potential option for PD unresponsive to medical management. Biomarkers are clinical and laboratory indicators of therapeutic success or failure. Read More

Gait Posture 2018 09 28;65:57-64. Epub 2018 Jun 28.

Ospedale Policlinico San Martino, IRCCS, Genoa, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health Unit, University of Genoa, Italy. Electronic address:

Background: Disturbance of gait is a key feature of Parkinson's disease (PD) and has a negative impact on quality of life. Deficits in cognition and sensorimotor processing impair the ability of people with PD to walk quickly, efficiently and safely. Recent evidence suggests that emotional disturbances may also affect gait in PD. Read More

Comput Math Methods Med 2018 4;2018:8019232. Epub 2018 Nov 4.

Centre for Innovation and Technology Assessment in Health, Postgraduate Program in Electrical and Biomedical Engineering, Faculty of Electrical Engineering, Federal University of Uberlândia, Uberlândia, Brazil.

Parkinson's disease (PD) is a neurodegenerative disorder that remains incurable. The available treatments for the disorder include pharmacologic therapies and deep brain stimulation (DBS). These approaches may cause distinct side effects and motor responses. Read More

Front Neurol 2018 23;9:1011. Epub 2018 Nov 23.

Hospital Clínico, Universidad de Chile, Santiago, Chile.

We report a successful bilateral globus pallidus internus-deep brain stimulation (GPi-DBS) for a Parkinson disease (PD) patient with idiopathic normal pressure hydrocephalus (INPH) and an unusually long anterior commissure-posterior commissure (AC-PC) line. A 54-year-old man presented with a history of 3 months of severe shuffling gait, rigidity, slow movements of the left side limbs, and difficulty managing finances. A brain MRI revealed marked ventriculomegaly (Evans index = 0. Read More

Gac Med Mex 2018 ;154(6):719-726

Laboratorio Clínico de Enfermedades Neurodegenerativas. Secretaría de Salud, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.

The original description of what currently is known as Parkinson's disease was published 200 years ago. During both these centuries, knowledge on symptomatology, pathophysiology, genetics and pharmaceutical and surgical treatment has significantly increased; however, this nosological entity continues to be of imprecise origin and progressive evolution. In the present review, the historical events that contributed to describe and improve the understanding of this disease are summarized. Read More

PLoS Comput Biol 2018 12 6;14(12):e1006606. Epub 2018 Dec 6.

Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.

In this paper, we present a novel Bayesian adaptive dual controller (ADC) for autonomously programming deep brain stimulation devices. We evaluated the Bayesian ADC's performance in the context of reducing beta power in a computational model of Parkinson's disease, in which it was tasked with finding the set of stimulation parameters which optimally reduced beta power as fast as possible. Here, the Bayesian ADC has dual goals: (a) to minimize beta power by exploiting the best parameters found so far, and (b) to explore the space to find better parameters, thus allowing for better control in the future. Read More

World Neurosurg 2019 Mar 27;123:443-452.e8. Epub 2018 Nov 27.

Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Introduction: Optimal surgical strategy for patients with tremor remains uncertain. We conducted a systematic review and meta-analysis evaluating randomized controlled trials of deep brain stimulation (DBS) and lesion surgery (LS) in the treatment of tremor.

Methods: We searched PubMed, Embase, and the Cochrane database to include randomized clinical trials with either LS, deep brain stimulation, or controls. Read More

J Clin Neurosci 2019 Jan 22;59:29-31. Epub 2018 Nov 22.

Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan.

Peri-electrode edema can occur after deep brain stimulation (DBS). The diagnosis and management of peri-electrode edema may be challenging. We herein report non-infectious peri-electrode edema after the placement of DBS electrodes in patients with Parkinson's disease (PD). Read More

Asian J Neurosurg 2018 Oct-Dec;13(4):1252-1253

Department of Neurosurgery, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Skin erosion and infection are common but serious problems in deep brain stimulation (DBS). They can lead to the removal of the entire DBS device and consequently stop the entire treatment. Of critical importance, therefore, is to find surgical solutions that allow to leave the complex DBS device in place when medical treatment fails in repeated skin complications, to allow continuing treatment in otherwise pharmacological refractory patients. Read More

PLoS One 2018 20;13(11):e0207761. Epub 2018 Nov 20.

Department of Electrical Engineering, University of Bridgeport, Bridgeport, CT, United States of America.

The hyperkinetic symptoms of Parkinson's Disease (PD) are associated with the ensembles of interacting oscillators that cause excess or abnormal synchronous behavior within the Basal Ganglia (BG) circuitry. Delayed feedback stimulation is a closed loop technique shown to suppress this synchronous oscillatory activity. Deep Brain Stimulation (DBS) via delayed feedback is known to destabilize the complex intermittent synchronous states. Read More

Mov Disord 2019 Jan 19;34(1):124-129. Epub 2018 Nov 19.

Tri-State Neurosurgery, Willis Knighton Health System, Shreveport, Louisiana, USA.

Introduction: Medically intractable tremors are a common, difficult clinical situation. Deep brain stimulation decreases Parkinson's disease resting tremor and essential tremor, but not all patients are candidates from a diagnostic, medical, or social standpoint, prompting the need for alternative surgical strategies.

Methods: We describe 13 patients with medically intractable tremor treated with laser interstitial thermal thalamotomy performed under general anesthesia using live MRI-guidance and the Clearpoint stereotactic system. Read More

J Clin Neurosci 2019 Mar 13;61:281-284. Epub 2018 Nov 13.

Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

Charcot spinal arthropathy (CSA) is a rare spinal disorder presenting neuropathic osteoarthropathy of facet joints leading to progressive destruction. After L4-5 PLIF, a 63-year-old woman with Parkinson's disease (PD) underwent L3-4 and L5-S1 PLIF for primary adjacent segment disease caused by degenerative change, which was found as facet joint osteophytes and a vacuum disc phenomenon with endplate sclerosis. However, her postural disorder from PD deteriorated, and strong opioid analgesics were administered for severe recurring low back pain. Read More

Front Neurol 2018 31;9:906. Epub 2018 Oct 31.

Department of Neurology, Faculty of Health Science, Medical University of Warsaw, Warsaw, Poland.

Subthalamic nucleus deep brain stimulation (STN-DBS) has been an established method in improvement of motor disabilities in Parkinson's disease (PD) patients. It has been also claimed to have an impact on balance and gait disorders in PD patients, but the previous results are conflicting. The aim of this prospective controlled study was to evaluate the impact of STN-DBS on balance disorders in PD patients in comparison with Best-Medical-Therapy (BMT) and Long-term-Post-Operative (POP) group. Read More

Expert Opin Biol Ther 2018 12 20;18(12):1235-1245. Epub 2018 Nov 20.

a Life and Health Sciences Research Institute (ICVS), School of Medicine , University of Minho , Braga , Portugal.

Introduction: The available therapeutic strategies for Parkinson's disease (PD) rely only on the amelioration of the symptomatology of the disease, lacking neuroprotection or neuroregeneration capacities. Therefore, the development of disease modifying strategies is extremely important for the management of PD in the long term. Areas covered: In this review, the authors provide an overview of the current therapeutic approaches for PD and the emerging use of stem cell transplantation as an alternative. Read More

Neuroimage Clin 2018 3;20:1246-1254. Epub 2018 Nov 3.

Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany. Electronic address:

Objective: To investigate the spatial and temporal pattern of cortical responses evoked by deep brain stimulation (DBS) of the subthalamic nucleus (STN) and ventral intermediate nucleus of the thalamus (VIM).

Methods: We investigated 7 patients suffering from Essential tremor (ET) and 7 patients with Parkinson's Disease (PD) following the implantation of DBS electrodes (VIM for ET patients, STN for PD patients). Magnetoencephalography (MEG) was used to record cortical responses evoked by electric stimuli that were applied via the DBS electrode in trains of 5 Hz. Read More

J Clin Neurophysiol 2019 Jan;36(1):67-73

Departments of Neurosurgery and.

Purpose: Local field potential recordings from deep brain stimulation (DBS) leads provide insight into the pathophysiology of Parkinson disease (PD). We recorded local field potential activity from DBS leads within the subthalamic nucleus in patients with PD undergoing DBS surgery to identify reproducible pathophysiological signatures of the disease.

Methods: Local field potentials were recorded in 11 hemispheres from patients with PD undergoing subthalamic nucleus-DBS. Read More

Front Neurol 2018 25;9:893. Epub 2018 Oct 25.

Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania "Luigi Vanvitelli, " Naples, Italy.

Impulse control behaviors (ICB) are recognized as non-motor complications of dopaminergic medications in patients with Parkinson's disease (PD). Compelling evidence suggests that ICB are not merely due to the PD-related pathology itself. Several risk factors have been identified, either demographic, clinical, genetic or neuropsychological. Read More

Neuroimage Clin 2018 16;20:1123-1128. Epub 2018 Oct 16.

Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO, United States. Electronic address:

Background: Implantation of deep brain stimulation (DBS) electrodes for the treatment of involuntary movement disorders, such as Parkinson's disease, routinely relies on the use of intraoperative electrophysiological confirmation to identify the optimal therapeutic target in the brain. However, only a few options exist to visualize the relative anatomic localization of intraoperative electrophysiological recordings with respect to post-operative imaging. We have developed a novel processing pipeline to visualize intraoperative electrophysiological signals registered to post-operative neuroanatomical imaging. Read More

J Korean Med Sci 2018 Oct 4;33(44):e279. Epub 2018 Oct 4.

Department of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Magnetic resonance-guided focused ultrasound (MRgFUS) is a new emerging neurosurgical procedure applied in a wide range of clinical fields. It can generate high-intensity energy at the focal zone in deep body areas without requiring incision of soft tissues. Although the effectiveness of the focused ultrasound technique had not been recognized because of the skull being a main barrier in the transmission of acoustic energy, the development of hemispheric distribution of ultrasound transducer phased arrays has solved this issue and enabled the performance of true transcranial procedures. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(6. Vyp. 2):99-104

Trapeznikov Institute of Control Sciences of Russian Academy of Sciences, Moscow, Russia.

The hardware-software system of differential diagnosis and evaluation of the efficacy of treatment of a number of extrapyramidal diseases (Parkinson's disease, essential tremor, idiopathic cervical dystonia) is based on the methodology of special processing of the electrical activity of muscles (EMG). The system defines the diagnosis for each investigated muscle, and determine various forms of extrapyramidal diseases including early preclinical ones. The system allows viewing the dynamics of changes in the patient's state, both in numerical characteristics and in the graphic interpretation, and evaluates the efficacy of various forms of treatment (medicament, surgical, etc. Read More

Clin Oral Implants Res 2018 Oct;29 Suppl 16:311-330

Division of Gerodontology and Removable Prosthodontics, University Clinics of Dental Medicine, University of Geneva, Geneva, Switzerland.

Objectives: his review evaluated implant survival in geriatric patients (≥75 years) and/or the impact of systemic medical conditions.

Materials And Methods: Systematic literature searches were performed to identify studies reporting on geriatric subjects with dental implants and on implant patients who had any of the seven most common systematic conditions among geriatric patients. Meta-analyses were performed on the postloading implant survival rates. Read More

Best Pract Res Clin Anaesthesiol 2018 Jun 2;32(2):187-202. Epub 2018 Jul 2.

Department of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA. Electronic address:

Psychotropic medications are widely prescribed by clinicians as both primary therapy for a variety of psychiatric and neurodegenerative diseases and as adjunctive analgesics for use in the perioperative period. It is critical to understand various modes of action, drug-drug interactions, side effects, and clinical implications. Health care providers must understand how these medications interact with anesthetics, as well as other drugs used in perioperative care. Read More

Drugs Aging 2018 12;35(12):1041-1054

Instituto de Medicina Molecular, Lisbon, Portugal.

End-of-dose motor fluctuations are regarded as one of the core troublesome symptoms by patients with Parkinson's disease (PD). Treatment of levodopa (L-dopa)-induced motor fluctuations is still an unmet medical need. L-dopa is the gold standard in the treatment of motor PD symptoms; notwithstanding, a wide range of adjunct therapies are currently available for the treatment of end-of-dose motor fluctuations. Read More

Neurosci Lett 2019 01 11;690:83-88. Epub 2018 Oct 11.

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University, Rome, Italy. Electronic address:

L-dopa-induced dyskinesias (LID) is a common motor side effect of levodopa therapy of Parkinson's disease (PD). The identified predictors may only partially account for the risk of developing LID and genetic factors may contribute to this variability. The present study is aimed to investigate whether polymorphisms in the dopamine transporter gene (DAT) are associated with the risk of developing LID. Read More

Int Rev Neurobiol 2018 19;141:405-438. Epub 2018 Sep 19.

Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania "Luigi Vanvitelli", Napoli, Italy; MRI Research Center SUN-FISM, University of Campania "Luigi Vanvitelli", Napoli, Italy. Electronic address:

Among modern neuroimaging modalities, magnetic resonance imaging (MRI) is a widely available, non-invasive, and cost-effective method to detect structural and functional abnormalities related to neurodegenerative disorders. In the last decades, MRI have been widely implemented to support PD diagnosis as well as to provide further insights into motor and non-motor symptoms pathophysiology, complications and treatment-related effects. Different aspects of the brain morphology and function may be derived from a single scan, by applying different analytic approaches. Read More

World Neurosurg 2019 Jan 4;121:e654-e660. Epub 2018 Oct 4.

Department of Neurosurgery, King's College Hospital NHS Foundation Trust, King's Health Partners, London, United Kingdom; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.

Objective: Patients' expectations are considered to play an important role in subthalamic nucleus (STN) deep brain stimulation (DBS). We explored the relationship among expectations, satisfaction, and outcome 6 years after surgery.

Methods: Fifteen patients with Parkinson disease (9 males, mean age 60. Read More

Int J Spine Surg 2018 Jan 30;12(1):15-21. Epub 2018 Mar 30.

Division of Spine Surgery, Department of Orthopaedic Surgery, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Patients with Parkinson's disease (PD) commonly develop severe spinal deformity, including scoliosis, antecollis, camptocormia, and Pisa syndrome. The etiology of PD-associated spinal deformity is not completely understood and in most cases is likely due to multiple interrelated factors, including central dystonia and focal myopathy. Once spinal deformity has occurred, surgery is often the only modality that can correct the condition, although control of the movement disorder through medication and deep brain stimulation may slow progression. Read More