10,295 results match your criteria Surgical Oncology[Journal]


Stage I-III colon cancer patients with tumor deposits behave similarly to stage IV patients. Cross-section analysis of 392 patients.

J Surg Oncol 2019 Apr 24. Epub 2019 Apr 24.

Surgical Oncology, Instituto Nacional de Cancerología, Mexico, Mexico.

Background And Objectives: Tumor deposits (TDs) are associated with adverse prognostic factors and decreased survival in colorectal cancer. However, controversy exists regarding their definition, evaluation, and staging categories. This study aimed to determine the survival and recurrence impact of the TD in colon adenocarcinomas; and to determine if TD patients behave similarly to stage IV patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25482DOI Listing
April 2019
2 Reads

A novel online prognostic tool to predict long-term survival after liver resection for intrahepatic cholangiocarcinoma: The "metro-ticket" paradigm.

J Surg Oncol 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio.

Background: The aim of the current study was to develop an online calculator to predict survival after liver resection for intrahepatic cholangiocarcinoma (ICC) based on the "metro-ticket" paradigm.

Methods: Between 1990 and 2016, patients who underwent liver resection for ICC were identified in an international multi-institutional database. The final multivariable model of survival was used to develop an online prognostic calculator of survival. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25480DOI Listing

Navigating difficult conversations.

J Surg Oncol 2019 Apr 18. Epub 2019 Apr 18.

Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.

Breaking bad news and navigating difficult conversations is challenging and a frequent occurrence in surgical oncology practice. Cancer communication recommendations are guided by ethical principles, legal precedence, and emerging evidence regarding patient preference and efficacy of communication tools. Evidence continues to mount supporting a patient-centered communication approach and a model of shared decision making. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25472DOI Listing

Minimally invasive versus open distal pancreatectomy for pancreatic neuroendocrine tumors: An analysis from the U.S. neuroendocrine tumor study group.

J Surg Oncol 2019 Apr 18. Epub 2019 Apr 18.

Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio.

Background: To determine short- and long-term oncologic outcomes after minimally invasive distal pancreatectomy (MIDP) with open distal pancreatectomy (ODP) for the treatment of pancreatic neuroendocrine tumor (pNET).

Methods: The data of the patients who underwent curative MIDP or ODP for pNET between 2000 and 2016 were collected from a multi-institutional database. Propensity score matching (PSM) was used to generate 1:1 matched patients with MIDP and ODP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25481DOI Listing
April 2019
3 Reads

Response to: Comparison of keystone flaps and skin grafts for oncologic reconstruction: A retrospective review.

J Surg Oncol 2019 Apr 17. Epub 2019 Apr 17.

Reconstructive Surgery & Regenerative Medicine Research Group (ReconRegen), Institute of Life Science 2, Swansea University Medical School, Swansea, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25478DOI Listing
April 2019
1 Read

Clinical and pathological outcomes of induction chemotherapy before neoadjuvant radiotherapy in locally-advanced rectal cancer.

J Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Division of Colorectal Surgery, Michigan Medicine, Ann Arbor, Michigan.

Background And Objectives: In North America, preoperative combination chemoradiation is the most commonly recommended and utilized approach to locally advanced rectal cancer. There is increasing interest in the use of induction chemotherapy (IC) before radiation and surgery in locally advanced rectal cancer. How widely IC is being used and whether it improves pathologic and oncologic outcomes is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25474DOI Listing

Sarcomas of the mandible.

J Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York.

Introduction: Sarcomas of the mandible are extremely rare tumors, with osteosarcoma being the most common, followed by Ewing's sarcoma MATERIALS AND METHODS: A retrospective review of the clinical records, imaging studies, and pathology slides of patients with sarcoma of the mandible at a Tertiary Care Cancer Center from 1998 to 2014 was undertaken. The impact of neoadjuvant chemotherapy and postoperative radiotherapy with or without chemotherapy was studied, and factors impacting upon local control and disease-specific survival were analyzed.

Results: Twenty-two patients were treated over the study period, comprising of 15 males and seven females. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jso.25477
Publisher Site
http://dx.doi.org/10.1002/jso.25477DOI Listing
April 2019
1 Read

Prognostic value of posttreatment HPV-specific antibodies in patients with oropharyngeal tumors.

J Surg Oncol 2019 Apr 15. Epub 2019 Apr 15.

Department of Genetics and Microbiology, Faculty of Science, Charles University, BIOCEV, Průmyslová, Vestec, Czech Republic.

Background: The presence of human papillomavirus (HPV)-specific antibodies in patients with head and neck cancer at enrollment has prognostic significance. In cervical carcinoma patients, the decrease of HPV E6/E7-specific antibodies appears to be associated with a better prognosis.

Methods: This prospective study with follow-up focused on the persistence and prognostic value of antibodies specific for HR HPV-derived VLPs and HPV16 E6/E7 oncoproteins in patients with oropharyngeal cancers. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jso.25473
Publisher Site
http://dx.doi.org/10.1002/jso.25473DOI Listing
April 2019
4 Reads

Extremity soft tissue sarcoma in the elderly: Are we overtreating or undertreating this potentially vulnerable patient population?

J Surg Oncol 2019 Apr 12. Epub 2019 Apr 12.

Division of Surgical Oncology, Department of Surgery, UC Davis Medical Center, University of California, Sacramento, California.

Background: As the U.S. population ages, differences in oncologic outcomes among the elderly have been recognized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25470DOI Listing

Percutaneous management of malignant biliary disease.

J Surg Oncol 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiology, Section of Interventional Radiology, Northwestern University, Chicago, Illinois.

Percutaneous biliary interventions have established their role in the management of benign and malignant biliary disease. There are limited data comparing procedures performed by gastroenterologists and interventional radiologists in managing malignant biliary obstruction. Endoscopic procedures performed by gastroenterologists are not completely benign with reported complications ranging from 2% to 15%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25471DOI Listing
April 2019
1 Read

Urgent surgery in colon cancer has no impact on survival.

J Surg Oncol 2019 Apr 12. Epub 2019 Apr 12.

Department of Surgery, Lukas Hospital, Neuss, Germany.

Background And Objectives: Despite advances in early detection of colon cancer, a minority of patients still require urgent surgery. Whether such urgent conditions result in poor outcome remains a topic of debate.

Methods: Using a prospectively maintained database, patients suffering exclusively from colon cancer and receiving either elective or emergent resection between 2001 and 2014 were analyzed with respect to overall, disease-specific, and relative survival using Cox regression and propensity score analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25469DOI Listing

Preoperative risk evaluation for pancreatic fistula after pancreaticoduodenectomy.

J Surg Oncol 2019 Apr 5. Epub 2019 Apr 5.

Department of Surgery, Surgical Outcomes and Quality Improvement Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Background: Pancreatic fistula remains common, with limited ability to risk stratify patients preoperatively. The objective of this study was to identify risk factors for clinically-relevant postoperative pancreatic fistula (CR-POPF) that are routinely available in the preoperative setting.

Methods: Preoperatively available variables for all pancreaticoduodenectomies from 2014-2017 were examined using a national clinical registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25464DOI Listing
April 2019
2 Reads

Preclinical imaging of epidermal growth factor receptor with ABY-029 in soft-tissue sarcoma for fluorescence-guided surgery and tumor detection.

J Surg Oncol 2019 Apr 4. Epub 2019 Apr 4.

Department of Orthaepedics, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.

Background And Objectives: Fluorescence-guided surgery using epidermal growth factor receptor (EGFR) targeting has been performed successfully in clinical trials using a variety of fluorescent agents. We investigate ABY-029 (anti-EGFR Affibody molecule labeled with IRDye 800CW) compared with a small-molecule perfusion agent, IRDye 700DX carboxylate, in a panel of soft-tissue sarcomas with varying levels of EGFR expression and vascularization.

Methods: Five xenograft soft-tissue sarcoma cell lines were implanted into immunosuppressed mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25468DOI Listing
April 2019
1 Read

Outcomes analysis of Goldilocks mastectomy and breast reconstruction: A single institution experience of 96 cases.

J Surg Oncol 2019 Apr 4. Epub 2019 Apr 4.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota.

Background: The Goldilocks mastectomy procedure involves local contouring of completely autologous breast tissue created by preserving and de-epithelializing the residual mastectomy flaps. The purpose of this study was to provide outcomes data for 96-Goldilocks mastectomy procedures analyzing indications, complications, relevant comorbidities, and adjuvant cancer treatment impacting reconstructive and aesthetic outcomes.

Methods: Comprehensive review of every patient who underwent Goldilocks mastectomy from 2012 to 2018 included relevant medical and surgical comorbidities, as well as complication profiles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25465DOI Listing

Concurrent palliative care in the surgical management of head and neck cancer.

Authors:
Susan D McCammon

J Surg Oncol 2019 Mar 29. Epub 2019 Mar 29.

Department of Otolaryngology, Department of Internal Medicine, Division of Gerontology, Geriatrics and Palliative Care, The University of Alabama, Birmingham, Alabama.

Head and neck cancer affects vital functions of speech, swallowing, breathing, and appearance. Overall survival remains poor and symptom burden is high for both patients with incurable disease at the end of life and for long-term survivors. Early and concurrent palliative care helps guide treatment decision making and support quality of life during and after treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25452DOI Listing

A nomogram for predicting recurrence after complete resection for thymic epithelial tumors based on the TNM classification: A multi-institutional retrospective analysis.

J Surg Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Objectives: This study aimed to compare the predictive ability between the Masaoka-Koga (M-K) staging system and the 8th TNM staging system for the recurrence of thymic epithelial tumors (TETs). In addition, a nomogram was developed on the basis of the proposed TNM classification to predict individual recurrence rate.

Methods: A retrospective study was performed on 445 patients who underwent complete resection (R0) of TETs between January 2000 and February 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25462DOI Listing

Short- and long-term survival has improved after radical cystectomy for bladder cancer in Québec during the years 2000-2015.

J Surg Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of Surgery, McGill University Health Centre, Montreal, Québec, Canada.

Background And Objectives: We evaluated the short- and long-term outcome in bladder cancer (BC) patients treated with radical cystectomy (RC) in Québec (Canada).

Methods: Data were collected from provincial registries on all BC patients who underwent RC in Québec province in 2000-2015. Outcomes were hospitalization rates and survival. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25456DOI Listing
March 2019
3 Reads

Variant hepatic arterial anatomy encountered during pancreatoduodenectomy does not influence postoperative outcomes or resection margin status: A matched pair analysis of 105 patients.

J Surg Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background/aim: Anatomic vascular abnormalities of the hepatic arteries are frequent. The aim of the study was to analyze the influence of hepatic arterial variations on postoperative morbidity and resection margin status after pancreatoduodenectomy (PD).

Materials/methods: Patients who underwent PD over a 7-year period (2010-2017) were included in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25461DOI Listing

Introduction: Role of palliative care for the surgical patient.

Authors:
Bridget N Fahy

J Surg Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of Surgery, Division of Surgical Oncology and Department of Internal Medicine, Division of Palliative Medicine, University of New Mexico, Albuquerque, New Mexico.

Palliative care (PC) seeks to improve the quality of life for patients facing serious illness. Several oncology organizations have guidelines about PC, reflecting the need to integrate PC into standard oncology care. Many surgical patients do not receive PC despite the need for these services and established surgical PC competencies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25449DOI Listing

Rapid return to function and stability with dual mobility components cemented into an acetabular reconstructive cage for large osseous defects in the setting of periacetabular metastatic disease.

J Surg Oncol 2019 Mar 25. Epub 2019 Mar 25.

Department of Orthopaedic Surgery, The Ohio State University, Columbus, Ohio.

Background And Objectives: Large acetabular defects secondary to metastatic disease frequently require extensive acetabular reconstruction. Techniques of acetabular reconstruction have been described, but no consensus for the management of these defects has been reached so far. We present our technique and patient outcomes for acetabular reconstruction by cementing a dual mobility cup into an acetabular cage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25463DOI Listing

High-level expression of PRSS3 correlates with metastasis and poor prognosis in patients with gastric cancer.

J Surg Oncol 2019 Mar 25. Epub 2019 Mar 25.

Department of Gastrointestinal Surgery, The Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.

Background And Objectives: Serine protease-3 (PRSS3) is a known contributor to the genesis and development of malignant tumors, although its role in gastric cancer (GC) is still unclear.

Methods: PRSS3 expression in GC tissue samples and its relationship with clinicopathological features were analyzed. Effects of GC cellular responses to the introduction of small interfering RNA (siRNA)-mediated and short hairpin RNA (shRNA)-mediated interference with tumor PRSS3 expression were also assessed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25448DOI Listing
March 2019
2 Reads

Malignant bowel obstruction.

Authors:
Robert S Krouse

J Surg Oncol 2019 Mar 25. Epub 2019 Mar 25.

Department of Surgery, University of Pennsylvania, Philadelphia, Pennylvania.

Malignant bowel obstruction (MBO) is a common problem for patients with advanced malignancy, especially colorectal and ovarian cancers. Symptoms include pain, bloating, nausea and vomiting, and inability to eat. Treatment options consist of a wide range of surgical and nonsurgical interventions (medications, endoscopic, or interventional radiology approaches). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25451DOI Listing

Current management of regional lymph nodes in patients with melanoma.

J Surg Oncol 2019 Mar 24. Epub 2019 Mar 24.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jso.25442
Publisher Site
http://dx.doi.org/10.1002/jso.25442DOI Listing
March 2019
3 Reads

Palliation of malignant ascites.

J Surg Oncol 2019 Mar 22. Epub 2019 Mar 22.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Malignant ascites (MA) carries a poor prognosis. It can have a significant impact on quality of life (QOL), with increasing abdominal distention, pain, and dyspnea. Diuretics typically do not work well for MA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25453DOI Listing
March 2019
1 Read

Black and white box: Take good gross pathology photographs.

J Surg Oncol 2019 Mar 22. Epub 2019 Mar 22.

Hospital Clínico Universitario de Valladolid, Unidad de Tumores Intraoculares del Adulto, Servicio de Oftalmología, Av Ramón y Cajal, Valladolid, Spain.

Macroscopic study of surgical samples sent to the histopathology lab provides the first diagnostic approach. Obtaining quality photographs of these pieces facilitates proper case documentation for publication, sharing, teaching and research.This device has been originally designed for enucleated eyes but it could be used for a wide diversity of human or animal samples including thyroids, pituitary glands, prostates… It can be coupled to any smartphone camera. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jso.25455
Publisher Site
http://dx.doi.org/10.1002/jso.25455DOI Listing
March 2019
3 Reads

Effect of younger age on survival outcomes in T1N0M0 breast cancer: A propensity score matching analysis.

J Surg Oncol 2019 Mar 20. Epub 2019 Mar 20.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation and Department of Breast Surgery, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Purpose: We evaluated the effect of younger age on recurrence risk in Chinese women diagnosed with T1N0M0 breast cancer (BC), using propensity score matching (PSM) analysis.

Methods: We included 365 women who were diagnosed with T1N0M0 BC between 2003 and 2016, and who received surgery at our center. They were classified as younger (≤40 years) and older (>40 years). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25457DOI Listing
March 2019
3 Reads

Evidence for integration of palliative care into surgical oncology practice and education.

J Surg Oncol 2019 Mar 20. Epub 2019 Mar 20.

Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, University of Colorado School of Medicine, Aurora, Colorado.

High-quality data support multiple clinical benefits of integrating palliative care into routine oncology care. Though these data come largely from the medical oncology literature, data from surgical oncology populations support similar associations between palliative care integration and improved clinical outcomes, all without compromise in survival. This paper will review data supporting palliative care integration into oncology care, with a focus on surgical populations and recommendations for incorporating palliative care into surgical oncology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25454DOI Listing

Identification of a nine-gene panel as a prognostic indicator for recurrence with muscle-invasive bladder cancer.

J Surg Oncol 2019 Mar 18. Epub 2019 Mar 18.

Department of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, China.

Background And Objectives: Bladder cancer is one of the most common and highly recurrent cancers worldwide. Recurrence-associated genes may potentially predict cancer recurrence. We aimed to construct a recurrence-associated gene panel to improve the prognostic prediction of bladder cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25446DOI Listing
March 2019
1 Read

Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma?

J Surg Oncol 2019 Mar 18. Epub 2019 Mar 18.

Division of Surgical Oncology, Department of Surgery, Oregon Health and Science University, Portland, Oregon.

Background: The prognostic benefit of sentinel lymph node biopsy (SLNB) and factors predictive of survival specifically in patients with acral lentiginous melanoma (ALM) are unknown.

Methods: The SEER database was queried for ALM cases that underwent SLNB from 1998 to 2013. Clinicopathological factors were correlated with SLN status, overall survival (OS), and melanoma-specific survival (MSS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25445DOI Listing
March 2019
1 Read

Prognostication in oncology.

Authors:
Bridget N Fahy

J Surg Oncol 2019 Mar 18. Epub 2019 Mar 18.

Department of Surgery, Division of Surgical Oncology and Department of Internal Medicine, Division of Palliative Medicine, University of New Mexico, Albuquerque, New Mexico.

Prognostication involves formulation and communication about the expected course of the disease and is unique in surgical oncology because of the need to incorporate patient, procedural, and cancer-related factors. Several tools and techniques are available to assist physicians in formulating prognosis on the basis of these factors. Use of established communication techniques are effective in discussing prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25428DOI Listing

Completion lymphadenectomy for a positive sentinel node biopsy in melanoma patients is not associated with a survival benefit.

J Surg Oncol 2019 Mar 18. Epub 2019 Mar 18.

Division of Surgical Oncology, Oregon Health & Science University, Portland, Oregon.

Background: Completion lymph node dissection (CLND) for sentinel lymph node (SLN) disease in melanoma patients is debated. We evaluated the impact of CLND on survival and assessed for predictors of nonsentinel node metastasis (positive CLND).

Methods: Positive SLN melanoma patients were retrospectively identified in the Sentinel Lymph Node Working Group database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25444DOI Listing
March 2019
1 Read

Multispectral photoacoustic imaging for the detection of subclinical melanoma.

J Surg Oncol 2019 Mar 15. Epub 2019 Mar 15.

Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Photoacoustic imaging (PAI) is a noninvasive technique for melanin detection within melanoma metastases. While ex vivo and early studies suggest promising clinical application, there are no standardized parameters for defining presence of melanoma metastases.

Methods: Following flank/hindlimb melanoma induction in BRaf-PTEN transgenic mice, bilateral inguinal lymph nodes (LN) were imaged in vivo at 4 to 8 weeks using PAI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25447DOI Listing
March 2019
1 Read

The optimal number of lymph nodes to evaluate among patients undergoing surgery for gallbladder cancer: Correlating the number of nodes removed with survival in 6531 patients.

J Surg Oncol 2019 Mar 12. Epub 2019 Mar 12.

Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research Institute, Columbus, Ohio.

Background: The aim of the current study was to identify the minimum number and the optimal range of lymph nodes (LNs) to be examined among patients with gallbladder cancer (GBC).

Methods: Between January 1, 2004, and December 31, 2015, patients with a diagnosis of GBC were identified in the National Cancer Database. A machine-based learning approach was used to identify the minimum number and range of LNs to evaluate relative to long-term outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25450DOI Listing
March 2019
1 Read

Current management of regional lymph nodes in patients with melanoma.

J Surg Oncol 2019 Mar 12. Epub 2019 Mar 12.

Department of Plastic and Reconstructive Surgery, University of Catania, Catania, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25443DOI Listing

Cytoreduction and hyperthermic intraperitoneal chemotherapy in metastatic colorectal cancer.

J Surg Oncol 2019 Apr 10;119(5):613-615. Epub 2019 Mar 10.

Department of Surgery, University of Chicago, Chicago, Illinois.

As the management of metastatic colorectal cancer (CRC) has evolved over the past decades, optimal management of CRC with peritoneal metastases remains controversial, especially about cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. In this review, we highlight the current data on this challenging disease process, as well as comment on its limitations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25438DOI Listing
April 2019
4 Reads

Ongoing and future directions in the management of metastatic colorectal cancer: Update on clinical trials.

J Surg Oncol 2019 Apr 10;119(5):642-652. Epub 2019 Mar 10.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Metastatic colorectal cancer (mCRC) continues to show poor outcomes, with many patients exhausting effective standard-of-care therapy. To explore the current landscape of clinical trials for mCRC, we reviewed over 600 clinical trials that are currently ongoing for mCRC patients. Immunotherapeutic agents form approximately 39% (includes monoclonal antibodies, viruses, vaccines, and immunomodulators) of all agents and targeted therapy forms 45% (tyrosine kinase inhibitors, epigenetic modulators, and others) of all agents being investigated for mCRC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jso.25441DOI Listing
April 2019
1 Read

Did outcomes improve in retroperitoneal sarcoma surgery?

Surg Oncol 2019 Mar 5;28:96-102. Epub 2018 Nov 5.

Surgical Oncology Unit, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.

In the last decades, the deeper understanding of the biological basis of the disease, along with the advances of surgical techniques and oncologic multimodal treatments, have led to an overall increase of survival of cancer patients. However, significant amelioration of the prognosis of rare and under-investigated tumors such as soft tissue sarcoma is less evident. In this review, main changes in the surgical management of retroperitoneal sarcoma (RPS) are discussed in order to figure out whether actual improvement in RPS outcome has been occurred in the last years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.suronc.2018.11.004DOI Listing

First report of in-situ preservation of a subcapsular parathyroid gland through super-meticulous capsular dissection during robotic radical thyroidectomy.

Surg Oncol 2019 Mar 26;28:9-13. Epub 2018 Oct 26.

Breast and Thyroid Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. Electronic address:

Purpose: Meticulous capsular dissection can preserve the function of the parathyroid gland in most patients, but it is difficult to identify and preserve the subcapsular parathyroid gland. We performed in-situ preservation of the subcapsular parathyroid gland during robotic radical thyroidectomy using super-meticulous capsular dissection, and evaluated its effect on postoperative parathyroid function.

Methods: A 45-year-old woman was admitted with bilateral thyroid nodules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.suronc.2018.10.009DOI Listing
March 2019
1 Read

Safety and efficacy of early oral feeding for enhanced recovery following gastrectomy for gastric cancer: A systematic review.

Surg Oncol 2019 Mar 19;28:88-95. Epub 2018 Nov 19.

Department of Surgery, Zuyderland Medical Center, Dr. H. van der Hoffplein 1, 6162 BG, Sittard-Geleen, the Netherlands.

Background: Early oral feeding (EOF) is believed to be a crucial item of Enhanced Recovery After Surgery (ERAS) programs. Though this is widely accepted for colorectal surgery, evidence for early oral feeding after gastrectomy is scarce. The aim of this review is to assess the evidence of safety and benefits of early oral feeding after gastrectomy in patients with gastric cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.suronc.2018.11.017DOI Listing

Distal pancreatectomy with en-bloc celiac axis resection (DP-CAR) through retroperitoneal-first laparoscopic approach (Retlap): A novel strategy for achieving accurate evaluation of resectability and minimal invasiveness.

Surg Oncol 2019 Mar 19;28:86-87. Epub 2018 Nov 19.

Department of Surgery, Fujita Health University, 1-98 Dengakugakubo, Kutsukake, Toyoake, Aichi, 470-1192, Japan.

Background: Distal pancreatectomy with en-bloc celiac axis resection (DP-CAR) for borderline resectable pancreatic body cancer is increasingly being performed [1,2]. For survival benefits, obtaining margin-free resection (R0 resection) is crucial [3]. However, in patients with cancer abutting the root of the celiac axis and/or SMA, accurate resectability using preoperative imaging is difficult to judge [4]. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.suronc.2018.11.015DOI Listing
March 2019
1 Read

A radiomics-based nomogram for the preoperative prediction of posthepatectomy liver failure in patients with hepatocellular carcinoma.

Surg Oncol 2019 Mar 14;28:78-85. Epub 2018 Nov 14.

Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Objectives: To develop and validate a radiomics-based nomogram for the preoperative prediction of posthepatectomy liver failure (PHLF) in patients with hepatocellular carcinoma (HCC).

Methods: One hundred twelve consecutive HCC patients who underwent hepatectomy were included in the study pool (training cohort: n = 80, validation cohort: n = 32), and another 13 patients were included in a pilot prospective analysis. A total of 713 radiomics features were extracted from portal-phase computed tomography (CT) images. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.suronc.2018.11.013DOI Listing

Three trocars laparoscopic right ileocolectomy for advanced small bowel neuroendocrine tumor.

Surg Oncol 2019 Mar 14;28:76-77. Epub 2018 Nov 14.

Department of Gastrointestinal Surgery, European School of Laparoscopic Surgery, Saint-Pierre University Hospital, Brussels, Belgium.

Background: In the last decade Reduced Port Laparoscopy (RPL) has been introduced to reduce the risks related to the trocars and abdominal wall trauma, with enhanced cosmetic outcomes. The authors report a 59 year old man with a small bowel neuroendocrine tumor, submitted to three trocars right ileocolectomy.

Video: Preoperative work-up, including endoscopic ultrasound, octreo-PET-CT and FDG PET-CT, showed a 15 mm small bowel low grade well differentiated neuroendocrine tumor with mesenteric and transverse mesocolic extension, until the muscularis propria of the 3rd duodenum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.suronc.2018.11.011DOI Listing

Long term survival analysis after hyperthermic intraperitoneal chemotherapy with oxaliplatin as a treatment for appendiceal peritoneal carcinomatosis.

Surg Oncol 2019 Mar 13;28:69-75. Epub 2018 Nov 13.

Centre de Recherche, Hôpital Maisonneuve-Rosemont, Université de Montréal, QC, Canada. Electronic address:

Background And Objectives: Complete cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) have been proven to lengthen survival in appendiceal peritoneal carcinomatosis (PC-A). The aim of this study was to analyze survival results of this therapy in our institution over the last 10 years.

Methods: Data was retrospectively reviewed and analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.suronc.2018.11.006DOI Listing
March 2019
1 Read

Robotic spleen-preserving splenic hilar lymphadenectomy for advanced proximal gastric cancer: A feasible and simplified procedure.

Surg Oncol 2019 Mar 14;28:67-68. Epub 2018 Nov 14.

Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China; Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China. Electronic address:

Background: Robotic systems recently have been introduced to overcome technical limitations of conventional laparoscopic gastrectomy, especially for complex procedures [1]. We developed a set of procedural operation steps for robotic spleen-preserving splenic hilar lymphadenectomy, which is difficult and recommended in D2 lymph node (LN) dissection during total gastrectomy [2-4].

Methods: The robotic operative procedures of splenic hilar lymphadenectomy using the da Vinci Si system were demonstrated in a step-by-step manner, with technical tips for each step, in the video clip. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.suronc.2018.11.014DOI Listing

Association between diabetes and oncological outcomes in patients undergoing neoadjuvant chemo-radiotherapy for rectal cancer.

Surg Oncol 2019 Mar 8;28:62-66. Epub 2018 Nov 8.

Zealand University Hospital, Department of Surgery, Lykkebækvej 1, 4600, Køge, Denmark; Institute for Clinical Medicine, Copenhagen University and Danish Colorectal Cancer Group, Copenhagen, Denmark.

Purpose: The aim of the study was to investigate, in a nationwide study, if diabetes and especially metformin exposure during neoadjuvant chemo-radiotherapy improves the oncological outcomes in patients with rectal cancer.

Methods And Materials: Patients undergoing neoadjuvant chemo-radiotherapy and curative intended resection for rectal cancer in Denmark between January 1, 2003 and July 1, 2015 were identified. Diabetes was defined as medically treated diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.suronc.2018.11.007DOI Listing

Validation of a peritoneal surface disease severity score in stage IIIC-IV ovarian cancer treated with cytoreduction and hyperthermic intraperitoneal chemotherapy.

Surg Oncol 2019 Mar 9;28:57-61. Epub 2018 Nov 9.

Department of Surgery, Head of Department, Hospital Universitario Virgen De La Arrixaca, Murcia, Spain.

Background: The aim of the present study is to evaluate and validate the PSDSS score as a prognostic tool in patients with stage IIIC-IV epithelial ovarian cancer (EOC) who are treated with a first cytoreduction with peritonectomy procedures and HIPEC, and to discuss the usefulness and applicability of this approach in decision making in clinical practice.

Patients And Methods: We analyzed a consecutive series of patients with stage IIIC-IV epithelial ovarian cancer treated by cytoreductive surgery and HIPEC between January 2012 and December 2016.

Results: A total of 115 consecutive patients diagnosed of stage IIIC-IV EOC were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.suronc.2018.11.005DOI Listing

The link between wound healing and escape from tumor dormancy.

Surg Oncol 2019 Mar 9;28:50-56. Epub 2018 Nov 9.

Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, N5020, Bergen, Norway; Department of Oncology and Medical Physics, Haukeland University Hospital, N5021, Bergen, Norway. Electronic address:

Tumor dormancy is considered one of the major unsolved questions in cancer biology. Understanding the mechanisms responsible for maintaining and interrupting dormancy would be a major step towards preventing overt metastatic disease. Increasing evidence points to tissue trauma and subsequent wound healing as contributing events in escape from dormancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.suronc.2018.11.009DOI Listing
March 2019
1 Read

Perioperative EOX treatment in operable locally advanced gastroesophageal adenocarcinoma: Prediction of tumor response by FDG -PET and histopathology.

Surg Oncol 2019 Mar 7;28:42-49. Epub 2018 Nov 7.

Turku University Hospital, Department of Digestive Surgery, Finland.

Purpose: The aim of this retrospective single-center analysis was to evaluate the feasibility of fluorine-18 fluorodeoxyglucose (FDG)-PET imaging in evaluating metabolic response of preoperative chemotherapy in the treatment of locally advanced operable gastroesophageal adenocarcinoma and to investigate the association between histopathologic and FDG-PET response and overall survival.

Methods: Patients with locally advanced adenocarcinoma of distal esophagus, gastroesophageal junction or stomach were assessed for the study during 2008-2012. After evaluation with endoscopy, computed tomography and FDG-PET, patients with clinical stage II or III disease were assigned for perioperative EOX (epirubicin-oxaliplatin-capecitabine) treatment targeted at three cycles both pre- and postoperatively, if possible. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09607404183005
Publisher Site
http://dx.doi.org/10.1016/j.suronc.2018.11.002DOI Listing
March 2019
4 Reads