3,466,326 results match your criteria Surgical Innovation [Journal]


[Endovascular Therapy of Splanchnic Artery Aneurysms: For Each and Every Aneurysm?]

Zentralbl Chir 2018 Dec 11. Epub 2018 Dec 11.

Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Jena, Deutschland.

True visceral artery aneurysms (VAA) and visceral artery pseudoaneurysms (VAPA) are located in the celiac trunk, the superior mesenteric artery and inferior mesenteric artery. In addition to surgical treatment, endovascular embolisation therapy of visceral aneurysms and pseudoaneurysms is an alternative interventional method that has developed precipitously over the last two decades and is considered a first-choice method in many centres. The procedure is characterised by a high technical success rate with a low complication rate. Read More

View Article
December 2018

[Use of Negative Pressure Wound Therapy with Instillation and Dwell Time for Wound Treatment - Results of an Expert Consensus Conference].

Zentralbl Chir 2018 Dec 11;143(6):609-616. Epub 2018 Dec 11.

Unfallchirurgie, Bundeswehrkrankenhaus Berlin, Deutschland.

Rinsing wounds with wound cleansing solutions has long been a recognised cornerstone in wound management as a means of removing cell debris and surface pathogens in wound exudates. In combination with surgical debridement and topical negative pressure wound therapy (NPWT), this can facilitate the intended progression from the inflammatory to the proliferative phase of wound healing. Procedures of topical negative pressure wound therapy with instillation and a defined exposure/dwell-time of topical solutions under cyclic compression and decompression with foam dressings (NPWTi-d) can remove cellular remnants and debris that may inhibit the healing process. Read More

View Article
December 2018
1 Read

[Acute Motor Failure of the N. Peroneus Profundus Caused by a Cystic Tibiofibular Joint].

Z Orthop Unfall 2018 Dec 11. Epub 2018 Dec 11.

Orthopädie und Traumatologie, Bürgerspital Solothurn, Solothurn, Schweiz.

A ganglion cyst is rarely the cause of peripheral nerve compression. In the lower extremity, it is important to distinguish clinically the symptoms from a radiculopathy. In the literature, neural damage of the peroneal nerve due to a ganglion cyst has been described. Read More

View Article
December 2018

Hypoxia Preconditioning of Human MSCs: a Direct Evidence of HIF-1α and Collagen Type XV Correlation.

Cell Physiol Biochem 2018 7;51(5):2237-2249. Epub 2018 Dec 7.

Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara,

Background/aims: Mesenchymal stromal cells (MSCs) hold considerable promise in bone tissue engineering, but their poor survival and potency when in vivo implanted limits their therapeutic potential. For this reason, the study on culture conditions and cellular signals that can influence the potential therapeutic outcomes of MSCs have received considerable attention in recent years. Cell maintenance under hypoxic conditions, in particular for a short period, is beneficial for MSCs, as low O2 tension is similar to that present in the physiologic niche, however the precise mechanism through which hypoxia preconditioning affects these cells remains unclear. Read More

View Article
December 2018

Transoral Robotic Surgery (TORS) for Bilateral Eagle Syndrome.

ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):36-40. Epub 2018 Dec 11.

Eagle syndrome is a rare and poorly understood clinical condition caused by an elongated or disfigured styloid process. The possible managements of Eagle syndrome include conservative medical treatment or surgical intervention. The surgical removal of the elongated styloid process may be efficiently achieved either by an intraoral or a transcervical approach. Read More

View Article
December 2018
4 Reads

Buccal Fat Pad: Report of 24 Cases and Literature Review of 1,635 Cases of Oral Defect Reconstruction.

ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):24-35. Epub 2018 Dec 11.

Maxillo-Facial Surgery Unit, Neurosensorial Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Objective: The buccal fat pad (BFP) has been progressively introduced into clinical practice for oral defect reconstruction. This study describes our experience with this technique and compares indications in the literature and outcomes.

Methods: We prospectively enrolled 24 patients presenting oral surgical defects and treated between January 2012 and January 2015 at our institution. Read More

View Article
December 2018

GLP1 Receptor Agonist Liraglutide Is an Effective Therapeutic Option for Perioperative Glycemic Control in Type 2 Diabetes within Enhanced Recovery After Surgery (ERAS) Protocols.

Eur Surg Res 2018 Dec 11;59(5-6):349-360. Epub 2018 Dec 11.

Background: Enhanced Recovery After Surgery (ERAS) protocols are multimodal perioperative care pathways designed to achieve early recovery after surgical procedures by maintaining preoperative organ function and reducing profound stress responses following surgery [Wilmore and Kehlet: BMJ 2001; 322(7284): 473-6]. Glucagon-like peptide-1 receptor agonists (GLP-1RAgs), such as liraglutide, have recently been widely used as antidiabetic agents in patients with type 2 diabetes (T2D) because they maintain blood glucose at an ideal level throughout the day, including during postprandial periods, thereby improving hypoglycemia and body weight more than insulin therapies. Additionally, the administration of liraglutide may exert cardiovascular, renal, and cerebral protective effects in T2D patients. Read More

View Article
December 2018

Assessment of Postoperative Outcomes in Spinal Epidural Abscess Following Surgical Decompression.

Spine J 2018 Dec 8. Epub 2018 Dec 8.

Center for Spine Health, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA; Department of Neurosurgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA; Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA. Electronic address:

Background Context: A spinal epidural abscess (SEA) is a serious condition that may be managed with antibiotics alone or with decompressive surgery combined with antibiotics.

Purpose: The objectives of this study were to assess the clinical outcomes of SEA after surgical management and to identify the patient-level factors that are associated with outcomes following surgical decompression and removal of SEA.

Study Design/setting: Retrospective chart review analysis. Read More

View Article
December 2018
6 Reads

Surgical Risk Stratification Based on Preoperative Risk Factors in Adult Spinal Deformity.

Spine J 2018 Dec 8. Epub 2018 Dec 8.

Department of Orthopedic Surgery, Keio University School of Medicine; Keio Spine Research Group. Electronic address:

Background Context: Corrective surgery for adult spinal deformity (ASD) improves health-related quality of life but has high complication rates. Predicting a patient's risk of perioperative and late postoperative complications is difficult, although several potential risk factors have been reported.

Purpose: To establish an accurate, ASD-specific model for predicting the risk of postoperative complications, based on baseline demographic, radiographic, and surgical invasiveness data in a retrospective case series. Read More

View Article
December 2018
1 Read

Developing a quality standard for verbal communication during CABG procedures.

Semin Thorac Cardiovasc Surg 2018 Dec 8. Epub 2018 Dec 8.

Department of Cardio-Thoracic Surgery, Leiden University Medical Center, Leiden.

Objective: Verbal communication during coronary artery bypass graft (CABG) procedures is essential for safe and efficient cardiac surgery, yet sensitive to failure due to a current lack of standardization. The goal of this study was to improve communication during CABG by identifying critical items in verbal interaction between surgeons, anesthetists and perfusionists.

Methods: Based on 6 video recordings, a list was assembled containing items of communication in CABG procedures. Read More

View Article
December 2018

Impact of a multimodal strategy combining a new standard of care and restriction of carbapenems, fluoroquinolones and cephalosporins, on antibiotic consumption and resistance of P.aeruginosa in an ICU.

Int J Antimicrob Agents 2018 Dec 8. Epub 2018 Dec 8.

Service de maladies infectieuses, Centre hospitalier Sud Ile-de-France, 77000 Melun. Electronic address:

Objectives: To assess if the postprescription review and feedback (PPRF) of all antibiotics with restriction of carbapenems, fluoroquinolones and third generation cephalosporins, along with a change of medical standard of care, impacted the consumption of antibiotics and bacterial resistance in a medical/surgical intensive care unit (MSICU).

Methods: A four years before (2007-2010) and after (2011-2014) retrospective comparative study. Antibiotics consumption was evaluated in Defined Daily Doses per 1000 patient days. Read More

View Article
December 2018

Molecular characterization of metaplastic breast carcinoma via next generation sequencing.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Division of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte 91010, USA.

Metaplastic breast carcinoma (MBC) is a rare subtype of breast cancer with variable morphology. MBC is more often triple negative (ER-, PR-, HER2-) and is associated with poorer clinical outcome when compared to infiltrating ductal carcinoma. The purpose of our study is to identify molecular alterations in MBC using next generation sequencing (NGS) which may aid chemotherapy selection and use of targeted therapy. Read More

View Article
December 2018

Thymic epithelial neoplasms with sebaceous differentiation: a clinicopathological and Immunohistochemical study of 8 cases.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, The university of Texas, M D Anderson Cancer Center, Houston, TX. Electronic address:

Eight cases of primary thymic epithelial neoplasms corresponding to seven thymomas and one thymic carcinoma with sebaceous differentiation are presented. The patients are five men and three women between the ages of 45 and 63years (average: 54years) who presented with non-specific symptomatology related to their mediastinal mass. All patients underwent complete surgical resection of the mediastinal mass. Read More

View Article
December 2018

Impact of Closed Facebook Group Participation on Female Hematology/Oncology Physicians.

J Oncol Pract 2018 Dec;14(12):e758-e769

Sarah Cannon Cancer Institutes at HCA Midwest Health, Overland Park, KS; University of Florida College of Medicine; Malcom Randall Veterans Affairs Medical Center, Gainesville; Florida Cancer Specialists, Deland, FL; University of Texas Southwestern Medical Center, Dallas, TX; and Cleveland Clinic Akron General, Akron, OH.

Purpose:: Meaningful connections are an important aspect of career satisfaction. The Hematology Oncology Women Physician Group (HOWPG) is a private Facebook (FB) group of 936 women who practice within the hematology/oncology (H/O) field. We hypothesized that HOWPG adds value to education, emotional wellness, and practice of oncology for its membership. Read More

View Article
December 2018
1 Read

Adjuvant Therapy for Biliary Tract Cancers.

J Oncol Pract 2018 Dec;14(12):701-708

South East Cancer Center, University Hospital Waterford, Waterford, Ireland; and Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.

Biliary tract cancers, including gallbladder cancer, intrahepatic, perihilar, and distal cholangiocarcinomas, although anatomically contiguous, represent a heterogeneous group of cancers with extensive biologic and genetic diversity. With early disease, surgical resection is the preferred option for all subtypes; however, relapse rates remain high, and survival outcomes are poor. Data to guide the use of adjuvant therapy have been limited to retrospective series, population-based studies, and meta-analyses, all with their associated limitations. Read More

View Article
December 2018

Primary liver carcinoma with sarcomatous changes: Analysis of 10 cases.

Hepatol Res 2018 Dec 7. Epub 2018 Dec 7.

Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

Background & Aim: Primary liver carcinoma with sarcomatous change is a rare malignancy associated with high aggressiveness and poor prognosis. However, the characteristics of these types of tumors are still unknown. The aim of this study was to assess the imaging features, prognostic significance, and clinicopathological characteristics of patients with these tumors. Read More

View Article
December 2018
1 Read

Management of common femoral artery occlusive disease: A review of endovascular treatment strategies and outcomes.

Catheter Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiovascular Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts.

Isolated atherosclerotic lesions of the common femoral artery (CFA) are rare but can produce significant claudication and critical limb ischemia. To date, the "gold standard" treatment for this entity has been common femoral endarterectomy (CFE) with or without patch angioplasty. However, surgery does have significant early postoperative complications, with a 15% combined mortality/morbidity. Read More

View Article
December 2018
1 Read

Patterns of infiltration and local recurrences of various types of cutaneous sarcomas following three-dimensional histology.

J Dtsch Dermatol Ges 2018 Dec;16(12):1434-1442

Department of Dermatology, Eberhardt Karls University, Tübingen Germany.

Background: Cutaneous sarcomas are rare and characterized by pathogenetic heterogeneity. Knowledge about local infiltration patterns and recurrence rates may be useful in improving patient care and outcomes. The objective of the present study was to compare these two characteristics in sarcomas that had been treated using the identical surgical procedure. Read More

View Article
December 2018
1 Read

Hind- and Midfoot Bone Morphology Varies with Foot Type and Sex.

J Orthop Res 2018 Dec 11. Epub 2018 Dec 11.

RR&D Center for Limb Loss and MoBility, VA Puget Sound, Seattle, WA.

Foot type has been associated with pain, injury, and altered gait mechanics. Morphological variations in foot bones due to foot type variation may impact surgical and therapeutic treatments. The purpose of this study was to utilize principal component analysis (PCA) to determine how morphology of the hind- and midfoot bones differs among foot types and sex. Read More

View Article
December 2018

Proton therapy for skull base tumors: A review of clinical outcomes for chordomas and chondrosarcomas.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

University of Florida Health Proton Therapy Institute, University of Florida College of Medicine, Jacksonville, Florida.

Background: Skull base chordomas and chondrosarcomas are rare tumors traditionally treated by surgical resection and adjuvant radiation therapy (RT). We will discuss data evaluating clinical outcomes of proton therapy in the treatment of skull base chordomas and chondrosarcomas.

Methods: A literature review was performed using a MEDLINE search from January 1990 to January 2017. Read More

View Article
December 2018

Tamoxifen therapy benefit predictive signature combining with prognostic signature in surgical-only ER-positive breast cancer.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of General Surgery, Huai'an Second People's Hospital, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.

Tamoxifen treatment is important assistant for estrogen-receptor-positive breast cancer (BRCA) after resection. This study aimed to identify signatures for predicting the prognosis of patients with BRCA after tamoxifen treatment. Data of gene-specific DNA methylation (DM), as well as the corresponding clinical data for the patients with BRCA, were obtained from The Cancer Genome Atlas and followed by systematic bioinformatics analyses. Read More

View Article
December 2018

The impact of blood type on transfusion after major emergency abdominal surgery.

Transfusion 2018 Dec 10. Epub 2018 Dec 10.

Center for Surgical Science (CSS), Department of Surgery, Zealand University Hospital, Køge & University of Copenhagen, København, Denmark.

Background: ABO dependent variation in von Willebrand factor (vWF) and factor VIII have an impact on hemostasis. Several contradictory studies have investigated the influence of ABO blood type in surgical hemorrhage. Emergency surgery is associated with an increased risk of perioperative hemorrhage leading to inferior clinical outcomes. Read More

View Article
December 2018

The current trends of Mg alloys in biomedical applications-A review.

J Biomed Mater Res B Appl Biomater 2018 Dec 7. Epub 2018 Dec 7.

School of Engineering and Technology, Central Michigan University, Mount Pleasant, Michigan, 48859.

Magnesium (Mg) has emerged as an ideal alternative to the permanent implant materials owing to its enhanced properties such as biodegradation, better mechanical strengths than polymeric biodegradable materials and biocompatibility. It has been under investigation as an implant material both in cardiovascular and orthopedic applications. The use of Mg as an implant material reduces the risk of long-term incompatible interaction of implant with tissues and eliminates the second surgical procedure to remove the implant, thus minimizes the complications. Read More

View Article
December 2018

Eight-week interval in flushing and locking port-a-cath in cancer patients: A single-institution experience and systematic review.

Eur J Cancer Care (Engl) 2018 Dec 10:e12978. Epub 2018 Dec 10.

Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Medical Oncology, University of Brescia at ASST Spedali Civili, Brescia, Italy.

Port-a-cath (PAC) system is one of the most frequently employed venous accesses for administration of chemotherapy and supportive care. To prevent late complications, the latest guidelines recommend flushing/locking procedures every four weeks. In this retrospective study, we evaluate the frequencies of late complications with a eight-week flushing/locking procedure compared to the standard one. Read More

View Article
December 2018

Impact of Diabetes on Clinical Periodontal Outcomes Following Non-Surgical Periodontal Therapy.

J Clin Periodontol 2018 Dec 8. Epub 2018 Dec 8.

Department of Periodontics and Dental Hygiene, University of Texas Health Science Center at Houston, Houston, TX.

Aim: This systematic review aimed to evaluate the impact of diabetes mellitus on clinical outcomes of non-surgical periodontal therapy.

Materials And Methods: Searches were conducted in electronic databases to screen studies published from January 1960 to August 2018. The included studies had at least two groups of patients: chronic periodontitis only (P) or both diabetes and chronic periodontitis (DMP). Read More

View Article
December 2018

Laryngeal mask airway versus endotracheal tube for percutaneous dilatational tracheostomy in critically ill adults.

Cochrane Database Syst Rev 2018 Nov 15;11:CD009901. Epub 2018 Nov 15.

Wiesbaden Business School, RheinMain University of Applied Science, Bleichstr. 44, Wiesbaden, Germany, 65183.

Background: Percutaneous dilatational tracheostomy (PDT) is one of the most common bedside surgical procedures performed in critically ill adults, on intensive care units (ICUs), who require long-term ventilation. PDT is associated with relevant life-threatening complications: Cuff rupture or accidental extubation may lead to hypoxia, aspiration or loss of airway. Puncture of the oesophagus, or creating a false passage during dilatation or replacement of the tracheostomy tube, can lead to pneumothorax or emphysema. Read More

View Article
November 2018
1 Read

Physiological in vitro sacroiliac joint motion: a study on three-dimensional posterior pelvic ring kinematics.

J Anat 2018 Dec 9. Epub 2018 Dec 9.

Fraunhofer Institute for Machine Tools and Forming Technology IWU, Dresden, Germany.

The sacroiliac joint (SIJ) is a well-known source of low back and pelvic pain, of increasing interest for both conservative and surgical treatment. Alterations in the kinematics of the pelvis have been hypothesized as a major cause of SIJ-related pain. However, definitions of both the range and the extent of physiological movement are controversial, and there are no clear baseline data for pathological alterations. Read More

View Article
December 2018

Pharmacotherapy for patent ductus arteriosus closure.

Authors:
John M Ferguson

Congenit Heart Dis 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

Even though up to 60% of premature infants less than 28 weeks gestation develop persistent patent ductus arteriosus (PDA), there remains controversy regarding if, when, and how to close the PDA. Failure to close the PDA has been associated with significant morbidity but no cause-and-effect has been proven for short-term or long-term outcomes in modern times. Surgical closure has the advantage of eliminating the PDA, but short-term complications and long-term adverse outcomes are worrisome. Read More

View Article
December 2018

Comparison of testis cancer-specific survival: an analysis of national cancer registry data from the USA, UK and Germany.

BJU Int 2018 Dec 9. Epub 2018 Dec 9.

Division of Urological Surgery and Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

View Article
December 2018

Variability in the Diagnosis of Surgical Site Infections After Full-Thickness Skin Grafting: An International Survey.

Br J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden.

Background: Diagnosis of a surgical site infection (SSI) in dermatologic surgery can be entirely based on a subjective assessment according to the 4 criterion of the most common definition of an SSI, which was established by the US Centers for Disease Control (CDC).

Objectives: To investigate the interobserver agreement between dermatologists in their diagnosis of SSI of dermatosurgical wounds.

Methods: An international electronic photographic survey with eight photographs of wounds 1 week after full-thickness skin grafting (FTSG) was sent to dermatologists. Read More

View Article
December 2018
1 Read

Incidence, severity, longitudinal trends and predictors of acute and chronic oxaliplatin-induced peripheral neuropathy in Taiwanese patients with colorectal cancer.

Eur J Cancer Care (Engl) 2018 Dec 10:e12976. Epub 2018 Dec 10.

Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Lin-Ko, Taiwan.

The purpose of this study was to evaluate the longitudinal incidence, severity, pattern of changes or predictors of oxaliplatin-induced peripheral neuropathy (OXAIPN) in Taiwanese patients with colorectal cancer. A longitudinal repeated measures study design was employed, and 77 participants were recruited from the colorectal and oncology departments of two teaching medical centres in Taiwan. Physical examinations were performed, and self-reports regarding adverse impacts of OXAIPN and quality of life were obtained at five time points throughout 12 cycles of chemotherapy (C/T). Read More

View Article
December 2018

A clinical trial with protracted infusion 5-fluorouracil and mitomycin C for localized squamous cell carcinoma of the anus.

Asia Pac J Clin Oncol 2018 Dec 9. Epub 2018 Dec 9.

Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Purpose: Mitomycin C (MMC) plus standard 5-fluorouracil (FU) infusion in weeks 1 and 5 often contributes to radiotherapy interruptions and possibly less-than-ideal outcomes in anal cancer. This study was to evaluate alternative strategies for chemotherapy delivery that might be less toxic or more efficacious, and outcomes of patient-initiated treatment interruption for severe acute toxicity.

Materials And Methods: This was a prospective, nonrandomized study for patients with T1-4N0-3M0 anal squamous carcinoma. Read More

View Article
December 2018
2 Reads

Risk Factors for Multiple Hemorrhages Following Tonsil Surgery in Children.

Laryngoscope 2018 Dec 8. Epub 2018 Dec 8.

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts, U.S.A.

Objectives/hypothesis: Although much is known about the incidence and risk factors for hemorrhage after tonsil surgery, the incidence and factors related to multiple episodes of hemorrhage are not well examined. Our objective was to identify risk factors that may contribute to multiple hemorrhages following tonsil surgery in children.

Study Design: Retrospective chart review. Read More

View Article
December 2018
1 Read

Elective neck dissection in metastatic cutaneous squamous cell carcinoma to the parotid gland: A systematic review and meta-analysis.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Otolaryngology, Head & Neck Surgery, Monash Health, Melbourne, Australia.

Current management of metastatic cutaneous squamous cell carcinoma (CSCC) to the parotid is surgical excision and postoperative radiotherapy. In the node-negative neck, there is debate about the role of elective neck dissection (END), irradiation or observation. This systematic review assesses the prevalence of occult cervical disease and the evidence for END. Read More

View Article
December 2018

Pre-operative factors influencing post-operative outcomes from MyoRing implantation in keratoconus.

Clin Exp Optom 2018 Dec 7. Epub 2018 Dec 7.

Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Background: To identify pre-operative factors that influence post-operative performance of a full-ring intra-corneal implant (MyoRing) for the management of keratoconus.

Method: In a retrospective study, medical records of 70 keratoconus eyes of 70 consecutive surgical patients with a mean age of 28.54 ± 6. Read More

View Article
December 2018

Palbociclib plus endocrine therapy in HER2 negative, hormonal receptor-positive, advanced breast cancer: A real-world experience.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Data from 423 human epidermal growth factor receptor 2-negative (HER2-), hormone receptor-positive (HR+) advanced breast cancer (aBC) patients treated with palbociclib and endocrine therapy (ET) were provided by 35 Italian cancer centers and analyzed for treatment outcomes. Overall, 158 patients were treated in first line and 265 in second/later lines. We observed 19 complete responses and 112 partial responses. Read More

View Article
December 2018
5 Reads

Wait times for endoscopic sinus surgery influence patient-reported outcome measures in patients with chronic rhinosinusitis who fulfill appropriateness criteria.

Int Forum Allergy Rhinol 2018 Dec 10. Epub 2018 Dec 10.

Division of Rhinology, Department of Otolaryngology-Head and Neck Surgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

Background: Previous studies on the impact of wait times for endoscopic sinus surgery (ESS) in medically recalcitrant chronic rhinosinusitis (rCRS) have not examined its influence on the 5 distinct symptoms domains of the 22-item Sino-Nasal Outcome Test (SNOT-22), and have not applied evidence-based surgical indications. Our primary study objective was to investigate the impact of ESS wait times on postoperative SNOT-22 global and symptom domain scores in patients with rCRS deemed "appropriate" surgical candidates.

Methods: This was a retrospective analysis of adult patients with rCRS undergoing ESS, categorized as "appropriate" surgical candidates. Read More

View Article
December 2018

Fetal myelomeningocele surgery: Only treating the tip of the iceberg.

Prenat Diagn 2018 Dec 10. Epub 2018 Dec 10.

Fetal Medicine Unit, Department of Obstetrics & Gynaecology, Mount Sinai Hospital and University of Toronto, Toronto, Canada.

Objective: Fetal myelomeningocele (fMMC) surgery improves infant outcomes when compared with postnatal surgery. Surgical selection criteria and the option of pregnancy termination, however, limit the number of cases that are eligible for prenatal surgery. We aimed to quantify what proportion of cases could ultimately benefit from fetal therapy. Read More

View Article
December 2018

Determinants for Meaningful Clinical Improvement of Pain and Health-Related Quality of Life After Spinal Cord Stimulation for Chronic Intractable Pain.

Neuromodulation 2018 Dec 10. Epub 2018 Dec 10.

Center for Applied Neuroscience (CeNAp), University Hospital (HU), Federal University of Santa Catarina State (UFSC), Florianópolis, SC, Brazil.

Objectives: Previous studies demonstrated significant improvement in mean pain scores and quality of life (QOL) scales in patients with chronic pain who underwent spinal cord stimulation (SCS). However, the number of individuals who experience relevant improvements in QOL, termed the meaningful clinical improvement (MCI), is not known. The present study investigated changes in pain measurements based on MCI after SCS. Read More

View Article
December 2018

Superior detection of metastatic cystic lymphadenopathy in patients with papillary thyroid cancer by utilization of thyroglobulin washout.

Head Neck 2018 Dec 9. Epub 2018 Dec 9.

Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

Background: Fine-needle aspiration (FNA) cytology has been the standard of care in the workup of cervical lymph nodes (LNs) in patients with recurrent papillary thyroid cancer (PTC) and suspicious cervical LNs. Recently, FNA thyroglobulin (TG) washout measurement has been proposed as an adjunct in the management of these patients. We hypothesize that using FNA-TG washout for suspicious cervical LNs would increase the accuracy of diagnosing metastatic disease especially in cystic and highly vascular cervical LN in patients with recurrent PTC. Read More

View Article
December 2018

AHNS series: Do you know your guidelines? Guideline recommendations for recurrent and persistent head and neck cancer after primary treatment.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Department of Otolaryngology - Head & Neck Surgery, Division of Head & Neck Oncology, University of Toronto, Sunnybrook Health Sciences and the Odette Cancer Centre, Michael Garron Hospital, Toronto, Ontario, Canada.

Locoregional recurrent/persistent head and neck cancer following primary treatment is a significant challenge as it is usually difficult to treat and has worse outcomes compared to the primary setting. Surgical resection of a local or regional recurrence offers the best chance of cure when feasible. Local recurrence outcomes vary by subsite with laryngeal recurrences having the best prognoses and hypopharynx having the worst. Read More

View Article
December 2018

Prostate cancer induces C/EBPβ expression in surrounding epithelial cells which relates to tumor aggressiveness and patient outcome.

Prostate 2018 Dec 11. Epub 2018 Dec 11.

Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.

Background: Implantation of rat prostate cancer cells into the normal rat prostate results in tumor-stimulating adaptations in the tumor-bearing organ. Similar changes are seen in prostate cancer patients and they are related to outcome. One gene previously found to be upregulated in the non-malignant part of tumor-bearing prostate lobe in rats was the transcription factor CCAAT/enhancer-binding protein-β (C/EBPβ). Read More

View Article
December 2018

Long noncoding RNA GACAT3 promotes glioma progression by sponging miR-135a.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Surgical Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China.

The long noncoding RNA (lncRNA) gastric cancer associated transcript 3 (GACAT3) has been reported to play important roles in human tumorigenesis. However, its expression pattern, functions, and underlying mechanism in glioma remain unclear. In the present study, we showed that GACAT3 is upregulated in glioma tissues and cell lines. Read More

View Article
December 2018

Cross-over type of supernumerary digastric muscle: a case report.

Folia Morphol (Warsz) 2018 Dec 11. Epub 2018 Dec 11.

Institute of Anatomy, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia, Slovenia.

A cross-over type asymmetric anomaly of the anterior belly of the right digastric muscle was observed during a cadaveric dissection of the submental region. Three irregularly-shaped supernumerary muscle bundles were found between the anterior bellies of the digastric muscles. Although the anomalies of the digastric muscles are often observed, this complicated pattern has not been previously reported. Read More

View Article
December 2018

Refractory Severe Thrombocytopenia during Pregnancy: How to Manage.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):803-807. Epub 2018 Dec 7.

Department of Anaesthesiology, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Thrombocytopenia is the most common hemostatic change in pregnancy, but severe thrombocytopenia is rare. One of the causes, immune thrombocytopenic purpura (ITP), is characterized by increased platelet destruction by immunoglobulin G (IgG) antibodies, presenting a high risk of hemorrhage for the patient, but also for the fetus, since antibodies may cross the placenta. We present the case of a 23-year-old pregnant woman with a history of Langerhans cell histiocytosis of the mandible submitted to surgery and chemotherapy when she was 10 years old, with diagnosis of ITP since then. Read More

View Article
December 2018

[Registry Research Funding of the German Society of Plastic, Reconstructive and Aesthetic Surgeons (DGPRÄC) and Research Funding Report 2017/2018].

Handchir Mikrochir Plast Chir 2018 Dec 10. Epub 2018 Dec 10.

Klinik und Poliklinik für Plastische, Hand- und Wiederherstellungschirurgie, Medizinische Hochschule Hannover.

Introduction: This report serves to publicize the research of academic institutions for Plastic Surgery within our society DGPRÄC in 2017/2018 and sequels the funding report of 2015/2016. Applications to public, non-public, or industrial funding organizations were evaluated. At the same time, this paper analyses the number of approved DFG applications in Plastic, Thoracic and Vascular Surgery in the GEPRIS system. Read More

View Article
December 2018

Surgical technique and outcomes for bilateral humeral lengthening for achondroplasia: 26-year experience.

Musculoskelet Surg 2018 Dec 10. Epub 2018 Dec 10.

ICATME, Hospital Universitari Quiron-Dexeus, Carrer Sabino de Arana, 5-19, 08028, Barcelona, Spain.

Background: Elongation in patients with achondroplasia provides better overall skeletal proportionality and significantly improves such individuals' access to their perineal region to self-manage personal hygiene. This paper describes our surgical technique and outcomes for bilateral humeral lengthening in achondroplasia patients over 26 years.

Methods: Ours was a retrospective study of 55 patients with achondroplasia-related short stature, in whom bilateral humeral lengthening was performed from 1990 to 2016. Read More

View Article
December 2018

PEEK versus metal cages in posterior lumbar interbody fusion: a clinical and radiological comparative study.

Musculoskelet Surg 2018 Dec 10. Epub 2018 Dec 10.

S.C. Ortopedia e Traumatologia, IRCCS Policlinico San Matteo, Università degli Studi di Pavia, Viale Camillo Golgi 19, 27100, Pavia, PV, Italy.

Background: Low back pain and sciatica represent a common disabling condition with a significant impact on the social, working and economic lives of patients. Transforaminal lumbar interbody fusion (TLIF) is a surgical procedure used in degenerative spine conditions. Several types of cages were used in the TLIF procedure. Read More

View Article
December 2018

Evolution of robot-assisted general surgery in Greece and Cyprus.

J Robot Surg 2018 Dec 8. Epub 2018 Dec 8.

Department of General, Bariatric, Laparoscopic and Robotic Surgery, Athens Medical Center, Distomou Str. 5-7, 15126, Athens, Greece.

Robot-assisted general surgery in Greece and Cyprus coincided with a devastating financial crisis. We hereby present the evolution of the technology in this unwelcoming environment, using data provided to us by the official distributor of the Da Vinci platform in these countries. Read More

View Article
December 2018

Use of commercially available sodium hyaluronate 0.18% eye drops for corneal epithelial healing in diabetic patients.

Int Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.

Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Purpose: To evaluate the effect of topical sodium hyaluronate (SH) 0.18% treatment on corneal epithelial healing after epithelial debridement in pars plana vitrectomy in diabetic patients.

Method: This is prospective and randomized clinical trial. Read More

View Article
December 2018
  • Page 1 of 69327