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    Gingival Tissue Response Following Placement of a Light Cure Dressing and a Non-eugenol Dressing after Periodontal Flap Procedure: A Comparative Clinical Study.
    J Nat Sci Biol Med 2018 Jan-Jun;9(1):65-71
    Department of Periodontics, Dr. Ziauddin Ahmad Dental College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
    Aim: The aim was to compare the gingival tissue response following placement of a light cure dressing (Barricaid) and a non-eugenol periodontal dressing (Coe-Pak) after periodontal flap procedure. This was carried out by evaluating plaque deposition underneath both the dressings, healing response and the patient preference for each.

    Materials And Methods: A total of 12 patients with chronic generalized periodontitis requiring surgery in at least two different quadrants were enrolled for this split-mouth study. Read More

    Improved vacuum sealing drainage for treatment of surgical site infection following posterior spinal internal fixation: A case report.
    Medicine (Baltimore) 2018 Feb;97(7):e9952
    Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Rationale: Surgical site infection (SSI) following spine surgeries involving internal fixation often require removing the instrument; however, this can cause spinal instability. Previous reports have demonstrated the usefulness of vacuum sealing drainage (VSD) therapy, but the cases require wound opening, aseptic condition to replace the VSD device, and a secondary operation to close the wound. Thus, to improve the VSD treatment and develop a maneuverable procedure, make sense in spine surgery. Read More

    Nursing wound care practices in Haiti: facilitators and barriers to quality care.
    Int Nurs Rev 2018 Feb 13. Epub 2018 Feb 13.
    School of Nursing, University of Ottawa, Ottawa, ON, Canada.
    Aim: To describe the facilitators and barriers for nurses to perform quality wound care in three surgical wards of a hospital in Port-au-Prince, Haiti.

    Background: Up to a quarter of patients in low- and middle-income countries may acquire at least one infection while hospitalized. There is a paucity of research investigating nursing wound care practices in low- and middle-income countries regarding the prevention of hospital-acquired infections. Read More

    Biomedical Applications of Recombinant Silk-Based Materials.
    Adv Mater 2018 Feb 13. Epub 2018 Feb 13.
    Bayreuther Zentrum für Kolloide und Grenzflächen (BZKG), Bayreuther Zentrum für Bio-Makromoleküle (bio-mac), Bayreuther Zentrum für Molekulare Biowissenschaften (BZMB), Bayreuther Materialzentrum (BayMAT), Bayerisches Polymerinstitut (BPI), University Bayreuth, Universitätsstr. 30, 95447, Bayreuth, Germany.
    Silk is mostly known as a luxurious textile, which originates from silkworms first cultivated in China. A deeper look into the variety of silk reveals that it can be used for much more, in nature and by humanity. For medical purposes, natural silks were recognized early as a potential biomaterial for surgical threads or wound dressings; however, as biomedical engineering advances, the demand for high-performance, naturally derived biomaterials becomes more pressing and stringent. Read More

    Role of plasma growth factor in the healing of chronic ulcers of the lower legs and foot due to ischaemia in diabetic patients.
    Postepy Dermatol Alergol 2017 Dec 31;34(6):601-606. Epub 2017 Dec 31.
    Department of Pathomorphology, Mazovian Bródno Hospital, Warsaw, Poland.
    Introduction: It has been demonstrated that plasma growth factor (PGF) responsible for proliferation of smooth muscle cells and fibroblasts significantly shortens treatment duration.

    Aim: To determine the role of human growth factor in the healing of ulcers due to ischaemic diabetic foot syndrome (DFS) following previous angioplasty of the blood vessels of the lower leg and foot.

    Material And Methods: The study group included 50 patients with ischaemic diabetic foot complicated by lower leg ulcers in which angioplasty of the stenotic arteries in the distal lower leg and foot was performed. Read More

    [Unilateral Wiltse intermuscular approach and contralateral decompression for the treatment of thoracolumbar burst fracture].
    Zhongguo Gu Shang 2017 May;30(5):453-457
    Department of Orthopaedics, the First Affiliated Hostpital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
    Objective: To compare the clinical effects and multifidus muscle injury of different approaches, including unilateral Wiltse intermuscular approach and intramuscular approach combined with contralateral decompression, in treating thoracolumbar burst fracture.

    Methods: Forty-three patients with thoracolumbar burst fracture were enrolled in the study from January 2010 to December 2014, including 29 males and 14 females with an average age of 42.3 years old(ranged from 21 to 64 years old). Read More

    Device Related Pressure Ulcers Pre and Post Identification and Intervention.
    J Pediatr Nurs 2018 Jan 31. Epub 2018 Jan 31.
    Orlando Health, United States. Electronic address:
    Problem: From 2014 to 2016, device related pressure injuries accounted for 62-81% of all hospital acquired pressure injuries. From January to June 2014, there were 5 BiPAP/CPAP pressure injuries noted, accounting for 3.579 injuries per 1000 ventilator days. Read More

    Alginate membranes loaded with hyaluronic acid and silver nanoparticles to foster tissue healing and to control bacterial contamination of non-healing wounds.
    J Mater Sci Mater Med 2018 Feb 2;29(3):22. Epub 2018 Feb 2.
    Department of Medical, Surgical and Health Sciences, University of Trieste, Piazza dell'Ospitale 1, I-34129, Trieste, Italy.
    Chronic non-healing wounds are a clinically important problem in terms of number of patients and costs. Wound dressings such as hydrogels, hydrocolloids, polyurethane films and foams are commonly used to manage these wounds since they tend to maintain a moist environment which is shown to accelerate re-epithelialization. The use of antibacterial compounds is important in the management of wound infections. Read More

    Evaluation of inguinal vascular surgical scars treated with closed incisional negative pressure wound therapy using three-dimensional digital imaging - a randomized controlled trial on bilateral incisions.
    Wound Repair Regen 2018 Jan 30. Epub 2018 Jan 30.
    Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
    Purpose of the investigation: Scar formation is an important, permanent surrogate marker for wound healing. The main aim of this randomized trial was to evaluate the effects of incisional negative pressure wound therapy (iNPWT) on scar formation in uncomplicated wound healing with 3-dimensional (3D) digital imaging.

    Basic Procedures: Patients undergoing bilateral inguinal incisions after vascular surgery were randomized to receive iNPWT and standard dressing on separate sides. Read More

    Update on management of diabetic foot ulcers.
    Ann N Y Acad Sci 2018 Jan;1411(1):153-165
    Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Diabetic foot ulcers (DFUs) are a serious complication of diabetes that results in significant morbidity and mortality. Mortality rates associated with the development of a DFU are estimated to be 5% in the first 12 months, and 5-year morality rates have been estimated at 42%. The standard practices in DFU management include surgical debridement, dressings to facilitate a moist wound environment and exudate control, wound off-loading, vascular assessment, and infection and glycemic control. Read More

    Effect of low-level laser therapy on the healing process of donor site in patients with grade 3 burn ulcer after skin graft surgery (a randomized clinical trial).
    Lasers Med Sci 2018 Jan 24. Epub 2018 Jan 24.
    Al Nasr Sport Club Medical Section, Dubai, United Arab Emirates.
    Skin graft is a standard therapeutic technique in patients with deep ulcers, but managing donor site after grafting is very important. Although several modern dressings are available to enhance the comfort of donor site, using techniques that accelerate wound healing may enhance patient satisfaction. Low-level laser therapy (LLLT) has been used in several medical fields, including healing of diabetic, surgical, and pressure ulcers, but there is not any report of using this method for healing of donor site in burn patients. Read More

    Testing Elevated Protease Activity: Prospective Analysis of 160 Wounds.
    Adv Skin Wound Care 2018 Feb;31(2):82-88
    In the Department of Dermatology, Venereology, and Allergology at University Medical Center Göttingen, Germany, Anike Lockmann, MD, is an Assistant Physician; Tillmann Schill, MD, is a Specialist Physician; Franziska Hartmann, MD, is an Assistant Physician; Lisa-Lena Grönemeyer, MD, is an Assistant Physician; Michael P. Schön, MD, is Professor and Chairman; and Kai-Martin Thoms, MD, is a Senior Physician. Ricarda Holzkamp, MD, is a Specialist Physician, Dermatology Practice, Osterode, Germany. Acknowledgments: Kai-Martin Thoms has disclosed speaker's fees from Systagenix Wound Management. Woundchek Protease Status was purchased at a reduced price for the purpose of this study. The authors have disclosed no other conflicts of interest regarding this article. Submitted December 21, 2016; accepted in revised form June 21, 2017.
    Objective: Given that local elevated protease activity (EPA) has been implicated in impaired wound healing, a prospective single-center study was conducted to assess protease activity in various wound types.

    Methods: Protease activity was determined using an easy-to-use test system (Woundchek Protease Status Test Kit; Systagenix, Gatwick, United Kingdom) in 160 wounds in 143 patients. The assay detects the combined activity of inflammatory proteases, mainly matrix metalloproteinases 8 and 9 and human neutrophil elastase. Read More

    The use of nanoparticles in wound treatment: a systematic review.
    Rev Esc Enferm USP 2018 Jan 8;51:e03272. Epub 2018 Jan 8.
    Universidade Federal do Ceará, Departamento de Enfermagem, Fortaleza, CE, Brasil.
    Objective: To analyze the effects of nanoparticle-based dressings on the wound healing process in in vitro animals and human cells based on scientific evidence.

    Method: A systematic review of the literature in LILACS, PubMed and Science Direct databases. The articles were selected and evaluated for the level of evidence by the application of STROBE. Read More

    Bleeding in cancer patients and its treatment: a review.
    Ann Palliat Med 2017 Dec 18. Epub 2017 Dec 18.
    Haven Hospice, Gainesville, FL 32605, USA.
    Bleeding is a common problem in cancer patients, related to local tumor invasion, tumor angiogenesis, systemic effects of the cancer, or anti-cancer treatments. Existing bleeds can also be exacerbated by medications such as bevacizumab, nonsteroidal anti-inflammatory drugs (NSAIDs), and anticoagulants. Patients may develop acute catastrophic bleeding, episodic major bleeding, or low-volume oozing. Read More

    A Multi-Component Strategy to Decrease Wound Complications after Open Infra-Inguinal Re-Vascularization.
    Surg Infect (Larchmt) 2018 Jan;19(1):87-94
    1 Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine/Michael E. DeBakey Veterans Affairs Medical Center , Houston, Texas.
    Background: Wound complications remain a significant source of morbidity for patients undergoing open infra-inguinal re-vascularization. The purpose of this study was to determine the impact of several infection-control strategies on post-operative wound complications after open infra-inguinal re-vascularization.

    Methods: A retrospective cohort study was conducted among all patients who underwent an open infra-inguinal re-vascularization procedure before and after 2014. Read More

    Packing versus non-packing outcomes for abscesses after incision and drainage.
    J Okla State Med Assoc 2017 02;110(2):78-9
    CLINICAL QUESTION: In non-diabetic, non-immunocompromised individuals with skin abscesses, does packing after incision and drainage (I&D) reduce the risk of recurrence or reintervention compared with not packing? ANSWER: No. If the abscess is less than 5 cm, packing does not affect outcomes. LEVEL OF EVIDENCE FOR THE ANSWER: B. Read More

    Cutaneous wound healing using polymeric surgical dressings based on chitosan, sodium hyaluronate and resveratrol. A preclinical experimental study.
    Colloids Surf B Biointerfaces 2018 Mar 21;163:155-166. Epub 2017 Dec 21.
    Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
    Wound healing is a complex and dynamic process that involves modifying the wound environment depending on the patient's health status. Scar formation depends on many factors that influence wound healing, are important to bear in mind because most of the negative factors involved can be stopped by implementing an adequate treatment. The consensus in wound therapy recommends dressings that should keep a moist and alkaline environment thus creating a protective barrier against mechanical stress and secondary infections, in view of promoting granulation. Read More

    LEAK study: design of a nationwide randomised controlled trial to find the best way to treat wound leakage after primary hip and knee arthroplasty.
    BMJ Open 2017 12 28;7(12):e018673. Epub 2017 Dec 28.
    Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
    Introduction: Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are highly successful treatment modalities for advanced osteoarthritis. However, prolonged wound leakage after arthroplasty is linked to prosthetic joint infection (PJI), which is a potentially devastating complication. On the one hand, wound leakage is reported as a risk factor for PJI with a leaking wound acting as afor micro-organisms. Read More

    Diagnosis and management of peristomal pyoderma gangrenosum: A systematic review.
    J Am Acad Dermatol 2017 Dec 26. Epub 2017 Dec 26.
    Department of Dermatology, University of California, San Francisco - San Francisco, CA. Electronic address:
    Background: Peristomal pyoderma gangrenosum (PPG) is an uncommon subtype of pyoderma gangrenosum. PPG is a challenging condition to diagnose and treat; no evidence-based guidelines exist.

    Objective: To identify important clinical features of PPG and effective treatments available for its management. Read More

    Designing a pain management protocol for craniotomy: A narrative review and consideration of promising practices.
    Surg Neurol Int 2017 6;8:291. Epub 2017 Dec 6.
    Department of Anesthesiology and Perioperative Medicine, University of California Los Angeles, UCLA, Los Angeles, California, USA.
    Background: Craniotomy is a relatively common surgical procedure with a high incidence of postoperative pain. Development of standardized pain management and enhanced recovery after surgery (ERAS) protocols are necessary and crucial to optimize outcomes and patient satisfaction and reduce health care costs.

    Methods: This work is based upon a literature search of published manuscripts (between 1996 and 2017) from Pubmed, Cochrane Central Register, and Google Scholar. Read More

    Incisional Negative-Pressure Wound Therapy for Perineal Wounds After Abdominoperineal Resection for Rectal Cancer, a Pilot Study.
    Adv Wound Care (New Rochelle) 2017 Dec;6(12):425-429
    Department of Surgery, IJsselland Hospital, Capelle aan de IJssel, The Netherlands.
    Abdominoperineal resection (APR) is associated with high incidence of surgical wound infections. The use of incisional negative-pressure wound therapy (iNPWT) is known to reduce wound infections for several surgical indications. The aim of this pilot study was to investigate the potential of a new portable negative-pressure therapy device on perineal wound healing in patients undergoing APR. Read More

    Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial.
    Lancet Diabetes Endocrinol 2018 Mar 20;6(3):186-196. Epub 2017 Dec 20.
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.
    Background: Diabetic foot ulcers are serious and challenging wounds associated with high risk of infection and lower-limb amputation. Ulcers are deemed neuroischaemic if peripheral neuropathy and peripheral artery disease are both present. No satisfactory treatment for neuroischaemic ulcers currently exists, and no evidence supports one particular dressing. Read More

    Local Modalities for Preventing Surgical Site Infections: An Evidence-based Review.
    J Am Acad Orthop Surg 2018 Jan;26(1):14-25
    From the Department of Orthopaedic Surgery, Warren Alpert Medical School at Brown University, Rhode Island Hospital, Providence, RI.
    Surgical site infections remain a dreaded complication of orthopaedic surgery, affecting both patient economics and quality of life. It is important to note that infections are multifactorial, involving both surgical and patient factors. To decrease the occurrence of infections, surgeons frequently use local modalities, such as methicillin-resistant Staphylococcus aureus screening; preoperative bathing; intraoperative povidone-iodine lavage; and application of vancomycin powder, silver-impregnated dressings, and incisional negative-pressure wound therapy. Read More

    Viable placental allograft as a biological dressing in the clinical management of full-thickness thermal occupational burns: Two case reports.
    Medicine (Baltimore) 2017 Dec;96(49):e9045
    aBozeman Deaconess Hospital, Wound and Hyperbaric Center, Bozeman, MontanabOsiris Therapeutics, Inc., Columbia, Maryland.
    Rationale: Occupational burn injuries can be detrimental and difficult to manage. The majority of complex cases are referred and managed at regional burn centers where access to specialized care is available. As an alternative to hospitalization with staged surgical procedures, placental products may be used for outpatient medical management of these common burn injuries, especially if access to a regional burn center is limited or restricted. Read More

    Management specificities for abdominal, pelvic and vascular penetrating trauma.
    J Visc Surg 2017 Nov 24. Epub 2017 Nov 24.
    Service de chirurgie viscérale et générale, hôpital d'instruction des armées Percy, 101, avenue Henri-Barbusse, BP 406, 92141 Clamart cedex, France; École du Val-de-Grâce, 1, place Alphonse-Laveran, 75230 Paris cedex 05, France. Electronic address:
    Management of patients with penetrating trauma of the abdomen, pelvis and their surrounding compartments as well as vascular injuries depends on the patient's hemodynamic status. Multiple associated lesions are the rule. Their severity is directly correlated with initial bleeding, the risk of secondary sepsis, and lastly to sequelae. Read More

    Wound healing of cutaneous substance losses based on infectious, inflammatory and traumatic skin disorders: The experience of a center.
    Ann Chir Plast Esthet 2017 Nov 24. Epub 2017 Nov 24.
    Département de chirurgie plastique et reconstructrice, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.
    Introduction: There is no reference available concerning the standard healing time based on dermatological diseases responsible for cutaneous substance losses. The aim of our study was to assess the healing time after surgical debridement of necrotizing fasciitis (NF), hidradenitis suppurativa (HS) and skin necrosis due to trauma (SNT) based on multiples existing co-morbidities among these patients to provide surgeons with accurate scientific data in order to inform and educate patients and nurses who are practicing care under the supervision of the surgeon.

    Materials And Methods: This was a retrospective study. Read More

    The Use of Vacuum Dressings for Dead Space Management in Deep Surgical Site Infections Allows Implant and Bone Graft Retention.
    Global Spine J 2017 Dec 28;7(8):756-761. Epub 2017 Jul 28.
    Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
    Study Design: Retrospective, descriptive study.

    Objectives: Managing early surgical site infection following elective lumbar spine surgery remains a challenge with controversy regarding retention of instrumentation and bone graft. Wound closure may also pose considerable challenges. Read More

    Controversies in venous thromboembolism: to treat or not to treat superficial vein thrombosis.
    Hematology Am Soc Hematol Educ Program 2017 Dec;2017(1):223-230
    Thrombosis Research Unit, Division of Hematology, Department of Medicine I, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany; and King's Thrombosis Service, Department of Hematology, King's College London, London, United Kingdom.
    The management of superficial vein thrombosis (SVT) is poorly defined and remains controversial overall. SVT has long been considered a benign, self-limited disease, but recent studies show that SVT carries a nonnegligible risk for recurrence, deep vein thrombosis, or pulmonary embolism. Current guidelines recommend the use of low-molecular-weight heparin or fondaparinux, but results of several surveys indicate that the majority of patients with SVT receive nonanticoagulant therapy only, which includes compression stockings or bandages, nonsteroidal anti-inflammatory drugs, topical application of heparin gel, or surgical interventions. Read More

    Digital Ischemia After Application of Self-Adherent Elastic Wrap Dressing: A Case Series.
    Pediatrics 2018 Jan 7;141(1). Epub 2017 Dec 7.
    Primary Children's Hospital, Salt Lake City, Utah; and Department of Orthopaedics, University of Utah, Salt Lake City, Utah.
    Self-adherent elastic wrap dressings are a convenient option to manage pediatric hand and finger injuries. However, when improperly applied, they have the potential to cause devastating complications. We detail in this report 5 cases of dressing-induced ischemic injury to the hand in pediatric patients with a review of the literature. Read More

    A rare case of failed healing in previously burned skin after a secondary burns.
    Burns Trauma 2017 4;5:32. Epub 2017 Dec 4.
    Victorian Adult Burns Service, Alfred Hospital, Melbourne, Australia.
    Background: Patients presenting with large surface area burns are common in our practice; however, patients with a secondary large burn on pre-existing burn scars and grafts are rare and not reported.

    Case Presentation: We report on an unusual case of a patient sustaining a secondary large burn to areas previously injured by a burn from a different mechanism. We discuss the potential implications when managing a case like this and suggest potential biological reasons why the skin may behave differently. Read More

    Developing outcome measures assessing wound management and patient experience: a mixed methods study.
    BMJ Open 2017 11 26;7(11):e016155. Epub 2017 Nov 26.
    Population Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS.
    Objectives: To develop outcome measures to assess practical management of primary surgical wounds and patient experience.

    Design: Mixed methods, including qualitative interviews and data extraction from published randomised controlled trials (RCTs).

    Setting: Two university-teaching NHS hospitals and three district NHS hospitals in the South West and Midlands regions of England. Read More

    Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding.
    Adv Mater 2018 Jan 22;30(4). Epub 2017 Nov 22.
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
    Bleeding complications arising from trauma, surgery, and as congenital, disease-associated, or drug-induced blood disorders can cause significant morbidities and mortalities in civilian and military populations. Therefore, stoppage of bleeding (hemostasis) is of paramount clinical significance in prophylactic, surgical, and emergency scenarios. For externally accessible injuries, a variety of natural and synthetic biomaterials have undergone robust research, leading to hemostatic technologies including glues, bandages, tamponades, tourniquets, dressings, and procoagulant powders. Read More

    Comparison of methods for determining the effectiveness of antibacterial functionalized textiles.
    PLoS One 2017 21;12(11):e0188304. Epub 2017 Nov 21.
    Faculty of Textile and Clothing Technology, Hochschule Niederrhein, University of Applied Science, Mönchengladbach, Germany.
    Antimicrobial functionalization of textiles is important for various applications, such as protection of textile materials from decomposition, generation of more effective wound dressings, and the prevention of infections or malodors resulting from bacterial growth. In order to test the efficacy of new products, their antibacterial activity needs to be evaluated. At present, several different procedures are being used for this purpose, hindering comparisons among different studies. Read More

    Measuring the microbiome of chronic wounds with use of a topical antimicrobial dressing - A feasibility study.
    PLoS One 2017 20;12(11):e0187728. Epub 2017 Nov 20.
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
    Background: Polymicrobial communities colonize all wounds, and biofilms are hypothesized to be a key link to the chronic state and stalled healing. Molecular methods offer greater insight when studying microbial ecology in chronic wounds, as only a small fraction of wound bacteria are cultured by currently available methods and studies have shown little agreement between culture and molecular based approaches. Some interventions, like dressings with oxidized silver, are reported to help the stalled wounds move to a normal healing trajectory but the underlying mechanisms are difficult to measure. Read More

    Considerations in surgical management of a Buschke-Lowenstein tumor in Netherton syndrome: A case report.
    Pediatr Dermatol 2017 Nov;34(6):e328-e330
    Department of Dermatology, Great Ormond Street Hospital, London, UK.
    Netherton syndrome is an autosomal recessive ichthyosis caused by mutations in SPINK5, with the classic triad of linearis circumflexa, trichorrhexis invaginata, and atopy. There are few reports of surgical management in individuals with Netherton syndrome and clinicians may be reluctant to operate for fear of wound-healing complications. This report describes a pediatric case of a Buschke-Lowenstein tumor of the natal cleft in a patient with Netherton syndrome that had failed to respond to medical management. Read More

    Advanced Management of Severe Keloids.
    Skinmed 2017 1;15(5):365-370. Epub 2017 Oct 1.
    Department of Dermatology and Cutaneous Surgery, University of South Florida, Morsani College of Medicine; Tampa, FL.
    Keloids negatively impact the health and quality of life of many affected dermatologic patients. Treating keloids is often difficult, and suboptimal responses are frequent. Fortunately, there are many treatment options available to the clinician that may lead to improved clinical outcomes. Read More

    Application of Materials as Medical Devices with Localized Drug Delivery Capabilities for Enhanced Wound Repair.
    Prog Mater Sci 2017 Aug 13;89:392-410. Epub 2017 Jun 13.
    Interdisciplinary Program for Bioengineering, Seoul National University College of Engineering, Seoul, Republic of Korea.
    The plentiful assortment of natural and synthetic materials can be leveraged to accommodate diverse wound types, as well as different stages of the healing process. An ideal material is envisioned to promote tissue repair with minimal inconvenience for patients. Traditional materials employed in the clinical setting often invoke secondary complications, such as infection, pain, foreign body reaction, and chronic inflammation. Read More

    Tissue Oxygenation and Negative-Pressure Wound Therapy When Applied to the Feet of Persons With Diabetes Mellitus: An Observational Study.
    J Wound Ostomy Continence Nurs 2017 Nov/Dec;44(6):517-523
    Ye-Na Lee, RN, CWCN, MSc, Diabetic Wound Center, Korea University Guro Hospital, Seoul, South Korea. Jong-Seok Lee, MD, Diabetic Wound Center, Korea University Guro Hospital, Seoul, South Korea. Seung-Kyu Han, MD, PhD, Diabetic Wound Center, Korea University Guro Hospital, Seoul, South Korea. Hye-Kyung Jung, RN, Diabetic Wound Center, Korea University Guro Hospital, Seoul, South Korea.
    Purpose: Our group has reported that negative-pressure wound therapy (NPWT) decreases tissue oxygenation by 84% in the foot of diabetic patients because the pad of the connecting drainage tube and foam sponge of the NPWT system compress the wound bed. The purpose of this study was to determine whether an NPWT modified dressing application reduces tissue oxygenation in the feet of persons with diabetes mellitus.

    Design: A prospective, clinical, observational study. Read More

    [Comparison of dressings and devices to secure peripheral venous catheters in the emergency department: suitability according to patient profile].
    Emergencias 2016 10;28(5):320-326
    Área de Urgencias, Hospital Clínic, Barcelona, España.
    Objectives: To identify the most suitably designed dressings and devices to secure peripheral venous catheters (PVCs) in different types of patients. To evaluate the traction force the dressings could withstand and times they are able to keep the PVC in place in the emergency department.

    Material And Methods: Quasi-experimental descriptive observational study with inferential statistics to compare variables. Read More

    Skin graft donor site: a procedure for a faster healing.
    Acta Biomed 2017 Oct 23;88(3):310-314. Epub 2017 Oct 23.
    University of Siena.
    Background: The authors want to evaluate the efficacy of fibrillary tabotamp dressing in skin graft-donor site. A comparison was made with Vaseline gauzes. Tabotamp is an absorbable haemostatic product of Ethicon (Johnson and Johnson) obtained by sterile and oxidized regenerated cellulose (Rayon). Read More

    Use of ultraportable vacuum therapy systems in the treatment of venous leg ulcer.
    Acta Biomed 2017 Oct 23;88(3):297-301. Epub 2017 Oct 23.
    University of Siena.
    Background: The high incidence of venous leg ulcers and the difficult to give a complete healing involves in an increase of costs for National Health System. Main therapies to obtain a fast healing are compressive bandages, treatment of abnormal venous flow and in-situ-strategies of wound care. Negative pressure therapy does not conventionally used, because these systems not allow the use of compression bandages. Read More

    Topical antimicrobial agents for pediatric burns.
    Burns Trauma 2017 19;5:33. Epub 2017 Oct 19.
    Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, University of Toronto, Rm D 712, 2075 Bayview Avenue, Toronto, ON M4N 3M5 Canada.
    While topical antimicrobial agents are indicated for most if not all burn wounds, the choice of a topical agent must consider many factors such as the wound depth, anticipated time to healing, need for surgical intervention, and the known cytotoxicity of the agent. Especially relevant to the pediatric burn patient are the antimicrobial agent's properties related to causing pain or irritation and the required frequency of application and dressings. This article will discuss the general principles surrounding the use of topical antimicrobials on burn wounds and will review the most common agents currently in use. Read More

    Removable Rigid Dressings for Postoperative Management of Transtibial Amputations: A Review of Published Evidence.
    PM R 2017 Oct 18. Epub 2017 Oct 18.
    University of California, Davis Medical Center, UCDAVIS Health System, Sacramento, CA.
    Forty years of clinical experience and peer-reviewed research studies support the use of nonweight-bearing removable rigid dressings (RRDs) as an effective means of postoperative management of transtibial amputations. We reviewed the published medical evidence regarding the use of RRDs as a postoperative management strategy, culminating in an evidence-based practice recommendation. Published peer-reviewed literature on the topic was searched and classified by level of evidence based on the research design using the scale recommended by the PM&R (level I through V). Read More

    Evolution of Prophylaxis Protocols for Venous Thromboembolism in Neurosurgery: Results from a Prospective Comparative Study on Low-Molecular-Weight Heparin, Elastic Stockings, and Intermittent Pneumatic Compression Devices.
    World Neurosurg 2018 Jan 13;109:e510-e516. Epub 2017 Oct 13.
    Department of Neurosurgery, Hopital de Hautepierre, Strasbourg, France.
    Background: The incidence of venous thromboembolism (VT) in neurosurgical practice is astonishingly high, representing a major cause of morbidity and mortality. Prophylaxis strategies include elastic stockings, low-molecular-weight heparin (LMWH), and intermittent pneumatic compression (IPC) devices.

    Objective: To assess the safety and efficacy of 2 different VT prophylaxis protocols implemented in a European neurosurgical center. Read More

    Comparison of non-surgical methods for the treatment of deep partial thickness skin burns of the hand.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Department of Thermal Injuries, Republican Vilnius University Hospital, Lithuania.
    This paper describes a randomized, controlled, parallel-group, single-center clinical trial designed to compare non surgical treatment methods of deep partial thickness skin burns of the hand. All patients were scanned with the Laser Doppler Imaging device to determine the depth of the burn wound. Viable keratinocytes sites were determined according to the established Perfusion Units (PU) measurement system. Read More

    Study protocol for a randomized controlled pilot-trial on the semiocclusive treatment of fingertip amputation injuries using a novel finger cap.
    Medicine (Baltimore) 2017 Oct;96(41):e8224
    aPediatric Surgery bCoordinating Centre for Clinical Trials Dresden cInstitute of Medical Microbiology and Hygiene, Carl Gustav Carus Medical Faculty, Technische Universität Dresden, Fetscherstrasse dFraunhofer Institute for Material and Beam Technology IWS Dresden eCarl Gustav Carus Medical Faculty, Technische Universität Dresden, Fetscherstrasse, Dresden, Germany fWrocław Medical University, Wybrzeże Ludwika Pasteura 1, Wrocław, Poland.
    Introduction: Fingertip amputation injuries are common in all ages. Conservatively treated fingertips can regenerate skin and soft tissues to form a functionally and cosmetically excellent new fingertip. Little is known about this ability that, in humans, is confined to the fingertips. Read More

    Composite Alginate-Hyaluronan Sponges for the Delivery of Tranexamic Acid in Postextractive Alveolar Wounds.
    J Pharm Sci 2018 Feb 5;107(2):654-661. Epub 2017 Oct 5.
    Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, Naples 80131, Italy.
    The management of wounds in patients on anticoagulant therapy who require oral surgical procedures is problematic and often results in a nonsatisfactory healing process. Here, we report a method to prepare an advanced dressing able to avoid uncontrolled bleeding by occluding the postextractive alveolar wounds, and simultaneously, capable of a fast release of tranexamic acid (TA). Composite alginate/hyaluronan (ALG/HA) sponge dressings loaded with TA were prepared by a straightforward internal gelation method followed by a freeze-drying step. Read More

    [Zitelli bilobed flap for the reconstruction of the nasal pyramid after excision of basal cell carcinoma (BCC)].
    Pan Afr Med J 2017 2;27:238. Epub 2017 Aug 2.
    Service Chirurgie Plastique, Brûlés et Chirurgie de la Main, Hôpital Avicenne, Rabat, Maroc.
    We report the case of a 65-year old patient presenting with well-defined nodular basal cell carcinom measuring 5mm in diameter in the right paramedian nasal tip and the superior margin of the nasal wing, near the free edge. The tumor was removed, with resection margin of 1mm. It was associated with multiple hyperkeratotic lesions spread across his face. Read More

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