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    A review of the safety and efficacy of inhaled methoxyflurane as an analgesic for outpatient procedures.
    Br J Anaesth 2018 May 12;120(5):1040-1048. Epub 2018 Feb 12.
    Peter MacCallum Cancer Centre, Melbourne, Australia; University of Melbourne, Melbourne, Australia.
    Methoxyflurane delivered via a hand-held inhaler is a proven analgesic which has been used in Australasia for emergency relief of trauma associated pain since the 1970s. The agent is self-administered by the patient under the supervision of trained personnel. More than 5 million patients have received inhaled methoxyflurane without significant side effects. Read More

    The Effect of Rhythmic Breathing on Pain of Dressing Change in Patients with Burns Referred to Ayatollah Mousavi Hospital.
    World J Plast Surg 2018 Jan;7(1):51-57
    Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
    Background: Burn is the worst tragedy among modern societies that individuals may experience. One of the most important problems of burns is pain; particularly at the time of treatment including burn dressings, debridement, surgical incisions and physiotherapy. The aim of this study was to determine the effect of rhythmic breathing on pain of dressing change in patients with burns. Read More

    Medical textiles in orthopedics: An overview.
    J Clin Orthop Trauma 2018 Mar 27;9(Suppl 1):S26-S33. Epub 2017 Oct 27.
    Department of Orthopaedics and Joint Replacement Surgery, Indraprastha Apollo Hospitals, New Delhi 110076, India.
    The use of textile in the medical field is not new; this has given rise to a new branch known as medical textiles. These are being used to repair or replace various other musculoskeletal tissues. The most common uses of biomaterials are to create aseptic conditions for protection, general health care, and hygiene including bedding and clothing, surgical gowns, face masks, head and shoe covers, sterilization wraps, suture anchors, fiber cast and braces/orthotics. Read More

    Inorganic Nanomaterials for Soft Tissue Repair and Regeneration.
    Annu Rev Biomed Eng 2018 Apr 5. Epub 2018 Apr 5.
    Department of Chemical Engineering, Arizona State University, Tempe, Arizona 85287-6106, USA; email:
    Inorganic nanomaterials have witnessed significant advances in areas of medicine including cancer therapy, imaging, and drug delivery, but their use in soft tissue repair and regeneration is in its infancy. Metallic, ceramic, and carbon allotrope nanoparticles have shown promise in facilitating tissue repair and regeneration. Inorganic nanomaterials have been employed to improve stem cell engraftment in cellular therapy, material mechanical stability in tissue repair, electrical conductivity in nerve and cardiac regeneration, adhesion strength in tissue approximation, and antibacterial capacity in wound dressings. Read More

    Efficacy of Chitosan-Based Dressing for Control of Bleeding in Excisional Wounds.
    Eplasty 2018 10;18:e14. Epub 2018 Mar 10.
    Section of Surgical Sciences, Department of Surgery, John Hopkins Bayview Medical Center, John Hopkins University School of Medicine, Baltimore, Md.
    Excessive bleeding is a complication of wound debridement in patients receiving anticoagulation treatment. Chitosan is a linear, positively charged polysaccharide that has potential as a hemostatic topical dressing. This study examined the hemostatic efficacy of the chitosan based Opticell dressing (Medline Industries, Chicago, Ill) in heparinized rats with excisional wounds mimicking debridement. Read More

    Inner Scar Umbilicus: New Horizons for Vertical Abdominoplasty.
    Plast Reconstr Surg 2018 Apr;141(4):507e-516e
    São Paulo, Brazil From the Division of Plastic Surgery, Botucatu Medical School-Paulista State University (Universidade Estadual Paulista).
    Background: It is reasonable that deflated tissue in massive weight loss patients may demand not only lifting but also some extent of central body tightening, by the fleur-de-lis procedure. Although achieving nice contouring results, poor visible scars, including umbilical complications, have restricted the indications for the anterior vertical approach. The purpose of this article is to present the authors' experience with the inner scar umbilical reconstruction, reflecting overall results in vertical abdominoplasties. Read More

    Treatment of partial thickness hand burn injuries in children with combination of silver foam dressing and zinc-hyaluronic gel: Case reports.
    Medicine (Baltimore) 2018 Mar;97(13):e9991
    Department of Paediatrics, Surgical Division.
    Rationale: Burns is a common type of traumatic injury in childhood. Nowadays, several wound dressings are available to treat the second-degree hand burns conservatively.

    Patient Concerns, Diagnoses: At the authors' institute, 37 children were treated conservatively with a special dressing at first intervention containing Aquacel Ag foam and Zn-hyaluronic gel to determine their effectiveness on partial thickness hand burns. Read More

    Pectin-honey hydrogel: Characterization, antimicrobial activity and biocompatibility.
    Biomed Mater Eng 2018 ;29(3):347-356
    Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2-5, 10095 Grugliasco (TO), Italy.
    Background: Novel pectin-honey hydrogels have been developed and characterized as medical device. Ideally, a wound dressing should maintain optimal fluid affinity, permit moisture evaporation, protect the wound from microbes, and have shape-conformability, biocompatibility, and antibacterial activity.

    Objective: A novel, simple and fast method to produce pectin-honey wound dressings is described. Read More

    Effect of an acrylic terpolymer barrier film beneath transparent catheter dressings on skin integrity, risk of dressing disruption, catheter colonisation and infection.
    Intensive Crit Care Nurs 2018 Mar 23. Epub 2018 Mar 23.
    N. I. Pirogov National Medical Surgical Center, Moscow, Russia.
    Objectives: We assessed the effect of a skin-protective terpolymer barrier film around the catheter insertion site on frequency of dressing disruptions and skin integrity issues (hyperaemia, skin irritation, residues of adhesives and moisture under the dressing). Secondary outcomes included colonisation of the central venous catheter (CVC) and rates of central line-associated bloodstream infection.

    Research Methodology: A monocentric, open-label, randomised controlled trial was performed comparing a control group receiving standard transparent catheter dressings without the skin-protecting barrier film and an intervention group receiving a transparent chlorhexidine-impregnated dressing with use of the skin-protective acrylic terpolymer barrier film (3M™ Cavilon™ No - Sting Barrier Film, 3 M Health Care, St. Read More

    Efficacy and adverse effects of topical chloramphenicol ointment use for surgical wounds: a systematic review.
    ANZ J Surg 2018 Mar 23. Epub 2018 Mar 23.
    Department of Surgery, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.
    Background: Chloramphenicol ointment is often used in plastic and dermatologic surgery as a topical antibiotic for surgical wounds, but evidence regarding its efficacy and side effects is lacking. In addition, anecdotal fear of aplastic anaemia exists from the oral use of this drug. We performed a systematic review of the literature to assess the efficacy and side effect profile of topical chloramphenicol ointment on non-ocular surgical wounds. Read More

    Skin Laceration in Collagenase Clostridium histolyticum Treatment for Dupuytren's Contracture.
    Orthop Nurs 2018 Mar/Apr;37(2):144-153
    Rafael Sanjuan-Cervero, MS, Orthopaedic Surgeon, Orthopedics and Traumatology Surgery, Hospital de Denia, Partida Beniadlà, Alicante, Spain; and Doctoral Program in Pharmacy, University of Granada, Granada, Spain. Francisco J. Carrera-Hueso, PhD, PharmD, Pharmacy Service, Hospital Dr Moliner, Valencia, Spain. Salvador Oliver-Mengual, BSN, Nursery, Grade of Nurse, Orthopedics and Traumatology Surgery, Hospital de Denia, Alicante, Spain. Maria A. Ramon-Barrios, BSN, Nursery, Grade of Nurse, Pharmacy Service, Hospital Dr Moliner, Valencia, Spain. Clayton A. Peimer, MD, Orthopaedic Surgeon, UP Health System Marquette/Duke Life Point, Marquette, MI. Narjis Fikri-Benbrahim, PhD, PharmD, Researcher, Academic Center in Pharmaceutical Care, University of Granada, Granada, Spain.
    Background: Dupuytren's contracture produces a progressive flexion contracture of the affected fingers. Collagenase Clostridium histolyticum produces breakdown of the cord in the hand and/or finger(s) that tightens as a result of the disease creating a contracture, allowing manual traction and cord rupture. One of the side effects is spontaneous skin laceration when the finger is extended. Read More

    [Nursing Care Experiences of Periwound Moisture-Associated Dermatitis After Simultaneous Pancreas-Kidney Transplantation].
    Hu Li Za Zhi 2018 Apr;65(2):109-118
    MSN, RN, Supervisor, Department of Nursing, National Taiwan University Hospital, Taiwan, ROC.
    Simultaneous pancreas-kidney (SPK) transplantation is the primary surgical treatment for type I diabetes mellitus with end-stage renal disease. However, this transplant surgery has a high-risk of surgical complications, including duodenal anastomotic leakage, which may lead to pancreas transplantation failure if the leakage worsens. This case report describes a patient who suffered from duodenal anastomotic leakage after SPK transplantation. Read More

    Selecting appropriate postoperative dressings to support wound healing and reduce surgical site infection.
    Br J Nurs 2018 Mar;27(6):S32-S35
    Freelance Tissue Viability Nurse and Health Visitor.
    The appropriate choice of postoperative dressing supports effective wound healing by providing a moist wound environment and reducing the risk of surgical site infection and blistering. Wound management is complex and practitioners need to consider the location of the wound, method of wound closure, expected exudate level and length of time the dressing needs to remain in place when selecting a product. The correct dressing selection will have a positive impact wound healing and the patient's quality of life. Read More

    The effect of wound dressings on infection following total joint arthroplasty.
    Arthroplast Today 2018 Mar 3;4(1):125-129. Epub 2017 Jul 3.
    Department of Orthopaedic Surgery, NYU Langone Medical Center's Hospital for Joint Diseases, New York, NY, USA.
    Background: The use of perioperative surgical wound dressings is an important factor in the mitigation of infection following total joint arthroplasty (TJA). Few studies have been published comparing wound dressings and infection rates after TJA.

    Methods: MEDLINE, PubMed, and EMBASE were searched for studies published between 2006 and 2016 reporting infection rates in patients using various wound dressings after undergoing TJA. Read More

    Local control of polymicrobial infections via a dual antibiotic delivery system.
    J Orthop Surg Res 2018 Mar 15;13(1):53. Epub 2018 Mar 15.
    United States Army Institute of Surgical Research, 3855 Roger Brooke Drive, Fort Sam Houston, San Antonio, TX, 78234, USA.
    Background: Contaminated traumatic open orthopedic wounds are frequently complicated by polymicrobial contamination and infection. In high-risk wounds, the standard of care comprises debridement and irrigation combined with antibiotics which can be applied directly or combined with systemic antibiotics. Recently, bioabsorbable chitosan sponges have been shown to be an effective single-agent delivery device for local antibiotics with and without negative pressure wound therapy (NPWT). Read More

    The Effectiveness of Applying Soft Tissue Bonding Adhesive Composed of 2-Ethyl Cyanoacrylate to Epidural Catheter Fixations Using Film Dressings: An Open-Label, Randomized, Parallel-Group Comparative Study.
    Anesth Analg 2018 Mar 12. Epub 2018 Mar 12.
    Background: Insufficient fixation of an epidural catheter may result in migration of the catheter and eventual catheter failure. However, the best fixation method remains to be established. Aron Alpha A (2-ethyl cyanoacrylate) adhesive is approved for clinical use and can be used for surgical adhesion to both skin and blood vessels. Read More

    Cost-effectiveness Analysis of Silver Delivery Approaches in the Management of Partial-thickness Burns.
    Wounds 2018 Feb 23. Epub 2018 Feb 23.
    Department of Plastic Surgery, Kuopio University Hospital, Kuopio, Finland.
    Introduction: Burn injury is a common type of traumatic injury that causes considerable morbidity and mortality, resulting in about 30,000 admissions annually in specialist burn centers and costing around $1 billion per year in the United States. One percent silver sulfadiazine has been utilized widely in the management of burns and newer silver dressings are on the market, including nanocrystalline silver dressings, silver-impregnated hydrofiber dressings, and silver-impregnated foam dressings.

    Objective: This study sought to determine the cost effectiveness of the newer silver dressings using clinical data from an indirect treatment comparison using silver sulfadiazine as the baseline. Read More

    A Neutrophil Proteomic Signature in Surgical Trauma Wounds.
    Int J Mol Sci 2018 Mar 7;19(3). Epub 2018 Mar 7.
    Leibniz-Institute for Plasma Science and Technology (INP Greifswald), ZIK Plasmatis, Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
    Non-healing wounds continue to be a clinical challenge for patients and medical staff. These wounds have a heterogeneous etiology, including diabetes and surgical trauma wounds. It is therefore important to decipher molecular signatures that reflect the macroscopic process of wound healing. Read More

    Optimal Compression Therapy and Wound Care for Venous Ulcers.
    Surg Clin North Am 2018 Apr 18;98(2):349-360. Epub 2017 Dec 18.
    ProMedica Jobst Vascular Institute, 2109 Hughes Drive, Toledo, OH 43606, USA.
    Venous leg ulcers remain a major public health issue with significant economic impact. Two main components of the management of patients with venous leg ulcers are compression therapy and wound care. This article addresses principles and specific aspects of compression therapy and focal wound care for patients with venous leg ulcers. Read More

    Postsurgical Treatment of Split Skin Graft Donor Sites in Dermatological Departments.
    Int J Low Extrem Wounds 2018 Mar 5;17(1):22-29. Epub 2018 Mar 5.
    1 Department of Dermatology, Venerology and Allergology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
    The surgical removal of split skin grafts (SSGs) leads to superficial wounds that can be covered with different wound dressings. Currently, international guidelines that recommend a standard treatment of the donor sites are not yet established. We developed a questionnaire to evaluate the treatment of SSG donor sites and sent it to all dermatological departments in Germany. Read More

    Praying Sitting Position for Pineal Region Surgery: An Efficient Variant of a Classic Position in Neurosurgery.
    World Neurosurg 2018 Feb 27. Epub 2018 Feb 27.
    Department of Neurosurgery, Helsinki University Hospital, Helsinki, Finland.
    Background: The sitting position has lost favor among neurosurgeons partly owing to assumptions of increased complications, such as venous air embolisms and hemodynamic disturbances. Moreover, the surgeon must assume a tiring posture. We describe our protocol for the "praying position" for pineal region surgery; this variant may reduce some of the risks of the sitting position, while providing a more ergonomic surgical position. Read More

    A Modern Approach to Preventing Prosthetic Joint Infections.
    J Knee Surg 2018 Feb 28. Epub 2018 Feb 28.
    Department of Orthopedic Surgery, Northwell Health-Lenox Hill Hospital, New York, New York.
    Total knee arthroplasty (TKA) is recognized as one of the most successful surgical procedures performed today. One of the most common and dreaded complications of TKA is postoperative infection. To prevent infections, it is critical to identify patients at high risk through analyzing their risk factors, and help in addressing them prior to surgery. Read More

    Treatment for superficial thrombophlebitis of the leg.
    Cochrane Database Syst Rev 2018 02 25;2:CD004982. Epub 2018 Feb 25.
    Department of Medicine and Ageing Sciences, University "G. D'Annunzio" of Chieti-Pescara, Via dei Vestini 31, Chieti Scalo, Italy, 66013.
    Background: The optimal treatment of superficial thrombophlebitis (ST) of the legs remains poorly defined. While improving or relieving the local painful symptoms, treatment should aim at preventing venous thromboembolism (VTE), which might complicate the natural history of ST. This is the third update of a review first published in 2007. Read More

    Influence of dressing application time after breast augmentation on cutaneous colonization: A randomized clinical trial.
    J Plast Reconstr Aesthet Surg 2018 Feb 20. Epub 2018 Feb 20.
    Translational Surgery Graduate Program and Division of Plastic Surgery, Universidade Federal de São Paulo - UNIFESP, Rua Botucatu, 740 - 2° andar, Vila Clementino, São Paulo, SP CEP 04023-900, Brazil.
    Concepts regarding the best way to treat a surgical wound vary, in literature, ranging from no dressing use to dressing maintenance for 24 to 48 hours or until suture removal. This study aimed to evaluate the influence of the length of dressing maintenance after breast augmentation with implants on cutaneous colonization and surgical site infection. This is a two-arm, parallel group, randomized clinical trial. Read More

    Gingival Tissue Response Following Placement of a Light Cure Dressing and a Non-eugenol Dressing after Periodontal Flap Procedure: A Comparative Clinical Study.
    J Nat Sci Biol Med 2018 Jan-Jun;9(1):65-71
    Department of Periodontics, Dr. Ziauddin Ahmad Dental College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
    Aim: The aim was to compare the gingival tissue response following placement of a light cure dressing (Barricaid) and a non-eugenol periodontal dressing (Coe-Pak) after periodontal flap procedure. This was carried out by evaluating plaque deposition underneath both the dressings, healing response and the patient preference for each.

    Materials And Methods: A total of 12 patients with chronic generalized periodontitis requiring surgery in at least two different quadrants were enrolled for this split-mouth study. Read More

    Improved vacuum sealing drainage for treatment of surgical site infection following posterior spinal internal fixation: A case report.
    Medicine (Baltimore) 2018 Feb;97(7):e9952
    Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Rationale: Surgical site infection (SSI) following spine surgeries involving internal fixation often require removing the instrument; however, this can cause spinal instability. Previous reports have demonstrated the usefulness of vacuum sealing drainage (VSD) therapy, but the cases require wound opening, aseptic condition to replace the VSD device, and a secondary operation to close the wound. Thus, to improve the VSD treatment and develop a maneuverable procedure, make sense in spine surgery. Read More

    Nursing wound care practices in Haiti: facilitators and barriers to quality care.
    Int Nurs Rev 2018 Feb 13. Epub 2018 Feb 13.
    School of Nursing, University of Ottawa, Ottawa, ON, Canada.
    Aim: To describe the facilitators and barriers for nurses to perform quality wound care in three surgical wards of a hospital in Port-au-Prince, Haiti.

    Background: Up to a quarter of patients in low- and middle-income countries may acquire at least one infection while hospitalized. There is a paucity of research investigating nursing wound care practices in low- and middle-income countries regarding the prevention of hospital-acquired infections. Read More

    Biomedical Applications of Recombinant Silk-Based Materials.
    Adv Mater 2018 Feb 13. Epub 2018 Feb 13.
    Bayreuther Zentrum für Kolloide und Grenzflächen (BZKG), Bayreuther Zentrum für Bio-Makromoleküle (bio-mac), Bayreuther Zentrum für Molekulare Biowissenschaften (BZMB), Bayreuther Materialzentrum (BayMAT), Bayerisches Polymerinstitut (BPI), University Bayreuth, Universitätsstr. 30, 95447, Bayreuth, Germany.
    Silk is mostly known as a luxurious textile, which originates from silkworms first cultivated in China. A deeper look into the variety of silk reveals that it can be used for much more, in nature and by humanity. For medical purposes, natural silks were recognized early as a potential biomaterial for surgical threads or wound dressings; however, as biomedical engineering advances, the demand for high-performance, naturally derived biomaterials becomes more pressing and stringent. Read More

    Role of plasma growth factor in the healing of chronic ulcers of the lower legs and foot due to ischaemia in diabetic patients.
    Postepy Dermatol Alergol 2017 Dec 31;34(6):601-606. Epub 2017 Dec 31.
    Department of Pathomorphology, Mazovian Bródno Hospital, Warsaw, Poland.
    Introduction: It has been demonstrated that plasma growth factor (PGF) responsible for proliferation of smooth muscle cells and fibroblasts significantly shortens treatment duration.

    Aim: To determine the role of human growth factor in the healing of ulcers due to ischaemic diabetic foot syndrome (DFS) following previous angioplasty of the blood vessels of the lower leg and foot.

    Material And Methods: The study group included 50 patients with ischaemic diabetic foot complicated by lower leg ulcers in which angioplasty of the stenotic arteries in the distal lower leg and foot was performed. Read More

    [Unilateral Wiltse intermuscular approach and contralateral decompression for the treatment of thoracolumbar burst fracture].
    Zhongguo Gu Shang 2017 May;30(5):453-457
    Department of Orthopaedics, the First Affiliated Hostpital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
    Objective: To compare the clinical effects and multifidus muscle injury of different approaches, including unilateral Wiltse intermuscular approach and intramuscular approach combined with contralateral decompression, in treating thoracolumbar burst fracture.

    Methods: Forty-three patients with thoracolumbar burst fracture were enrolled in the study from January 2010 to December 2014, including 29 males and 14 females with an average age of 42.3 years old(ranged from 21 to 64 years old). Read More

    Device Related Pressure Ulcers Pre and Post Identification and Intervention.
    J Pediatr Nurs 2018 Jan 31. Epub 2018 Jan 31.
    Orlando Health, United States. Electronic address:
    Problem: From 2014 to 2016, device related pressure injuries accounted for 62-81% of all hospital acquired pressure injuries. From January to June 2014, there were 5 BiPAP/CPAP pressure injuries noted, accounting for 3.579 injuries per 1000 ventilator days. Read More

    Alginate membranes loaded with hyaluronic acid and silver nanoparticles to foster tissue healing and to control bacterial contamination of non-healing wounds.
    J Mater Sci Mater Med 2018 Feb 2;29(3):22. Epub 2018 Feb 2.
    Department of Medical, Surgical and Health Sciences, University of Trieste, Piazza dell'Ospitale 1, I-34129, Trieste, Italy.
    Chronic non-healing wounds are a clinically important problem in terms of number of patients and costs. Wound dressings such as hydrogels, hydrocolloids, polyurethane films and foams are commonly used to manage these wounds since they tend to maintain a moist environment which is shown to accelerate re-epithelialization. The use of antibacterial compounds is important in the management of wound infections. Read More

    Evaluation of inguinal vascular surgical scars treated with closed incisional negative pressure wound therapy using three-dimensional digital imaging-A randomized controlled trial on bilateral incisions.
    Wound Repair Regen 2018 01 7;26(1):77-86. Epub 2018 Mar 7.
    Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
    Purpose Of The Investigation: Scar formation is an important, permanent surrogate marker for wound healing. The main aim of this randomized trial was to evaluate the effects of incisional negative pressure wound therapy (iNPWT) on scar formation in uncomplicated wound healing with 3-dimensional (3D) digital imaging.

    Basic Procedures: Patients undergoing bilateral inguinal incisions after vascular surgery were randomized to receive iNPWT and standard dressing on separate sides. Read More

    Update on management of diabetic foot ulcers.
    Ann N Y Acad Sci 2018 Jan;1411(1):153-165
    Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Diabetic foot ulcers (DFUs) are a serious complication of diabetes that results in significant morbidity and mortality. Mortality rates associated with the development of a DFU are estimated to be 5% in the first 12 months, and 5-year morality rates have been estimated at 42%. The standard practices in DFU management include surgical debridement, dressings to facilitate a moist wound environment and exudate control, wound off-loading, vascular assessment, and infection and glycemic control. Read More

    A Systematic Integrative Review of Pin Site Crusts.
    Orthop Nurs 2018 Jan/Feb;37(1):36-42
    Dimitra-Simone Georgiades, Masters of Acute Care Nursing, Griffith University, Gold Coast Queensland; Registered Nurse at the Royal Brisbane and Women's Hospital, Queensland, Australia.
    There continues to be a lack of knowledge in the overall management of pin site crusts for orthopaedic clinicians to make evidence-based decisions on their retention or removal. The goal of pin site care is to reduce, or where possible, prevent pin site infection. Understanding the role of pin site crusts in the management of the pin site and prevention of pin site infection is important. Read More

    Effect of low-level laser therapy on the healing process of donor site in patients with grade 3 burn ulcer after skin graft surgery (a randomized clinical trial).
    Lasers Med Sci 2018 Apr 24;33(3):603-607. Epub 2018 Jan 24.
    Al Nasr Sport Club Medical Section, Dubai, United Arab Emirates.
    Skin graft is a standard therapeutic technique in patients with deep ulcers, but managing donor site after grafting is very important. Although several modern dressings are available to enhance the comfort of donor site, using techniques that accelerate wound healing may enhance patient satisfaction. Low-level laser therapy (LLLT) has been used in several medical fields, including healing of diabetic, surgical, and pressure ulcers, but there is not any report of using this method for healing of donor site in burn patients. Read More

    Testing Elevated Protease Activity: Prospective Analysis of 160 Wounds.
    Adv Skin Wound Care 2018 Feb;31(2):82-88
    In the Department of Dermatology, Venereology, and Allergology at University Medical Center Göttingen, Germany, Anike Lockmann, MD, is an Assistant Physician; Tillmann Schill, MD, is a Specialist Physician; Franziska Hartmann, MD, is an Assistant Physician; Lisa-Lena Grönemeyer, MD, is an Assistant Physician; Michael P. Schön, MD, is Professor and Chairman; and Kai-Martin Thoms, MD, is a Senior Physician. Ricarda Holzkamp, MD, is a Specialist Physician, Dermatology Practice, Osterode, Germany. Acknowledgments: Kai-Martin Thoms has disclosed speaker's fees from Systagenix Wound Management. Woundchek Protease Status was purchased at a reduced price for the purpose of this study. The authors have disclosed no other conflicts of interest regarding this article. Submitted December 21, 2016; accepted in revised form June 21, 2017.
    Objective: Given that local elevated protease activity (EPA) has been implicated in impaired wound healing, a prospective single-center study was conducted to assess protease activity in various wound types.

    Methods: Protease activity was determined using an easy-to-use test system (Woundchek Protease Status Test Kit; Systagenix, Gatwick, United Kingdom) in 160 wounds in 143 patients. The assay detects the combined activity of inflammatory proteases, mainly matrix metalloproteinases 8 and 9 and human neutrophil elastase. Read More

    The use of nanoparticles in wound treatment: a systematic review.
    Rev Esc Enferm USP 2018 Jan 8;51:e03272. Epub 2018 Jan 8.
    Universidade Federal do Ceará, Departamento de Enfermagem, Fortaleza, CE, Brasil.
    Objective: To analyze the effects of nanoparticle-based dressings on the wound healing process in in vitro animals and human cells based on scientific evidence.

    Method: A systematic review of the literature in LILACS, PubMed and Science Direct databases. The articles were selected and evaluated for the level of evidence by the application of STROBE. Read More

    Bleeding in cancer patients and its treatment: a review.
    Ann Palliat Med 2017 Dec 18. Epub 2017 Dec 18.
    Haven Hospice, Gainesville, FL 32605, USA.
    Bleeding is a common problem in cancer patients, related to local tumor invasion, tumor angiogenesis, systemic effects of the cancer, or anti-cancer treatments. Existing bleeds can also be exacerbated by medications such as bevacizumab, nonsteroidal anti-inflammatory drugs (NSAIDs), and anticoagulants. Patients may develop acute catastrophic bleeding, episodic major bleeding, or low-volume oozing. Read More

    A Multi-Component Strategy to Decrease Wound Complications after Open Infra-Inguinal Re-Vascularization.
    Surg Infect (Larchmt) 2018 Jan;19(1):87-94
    1 Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine/Michael E. DeBakey Veterans Affairs Medical Center , Houston, Texas.
    Background: Wound complications remain a significant source of morbidity for patients undergoing open infra-inguinal re-vascularization. The purpose of this study was to determine the impact of several infection-control strategies on post-operative wound complications after open infra-inguinal re-vascularization.

    Methods: A retrospective cohort study was conducted among all patients who underwent an open infra-inguinal re-vascularization procedure before and after 2014. Read More

    Packing versus non-packing outcomes for abscesses after incision and drainage.
    J Okla State Med Assoc 2017 02;110(2):78-9
    CLINICAL QUESTION: In non-diabetic, non-immunocompromised individuals with skin abscesses, does packing after incision and drainage (I&D) reduce the risk of recurrence or reintervention compared with not packing? ANSWER: No. If the abscess is less than 5 cm, packing does not affect outcomes. LEVEL OF EVIDENCE FOR THE ANSWER: B. Read More

    Cutaneous wound healing using polymeric surgical dressings based on chitosan, sodium hyaluronate and resveratrol. A preclinical experimental study.
    Colloids Surf B Biointerfaces 2018 Mar 21;163:155-166. Epub 2017 Dec 21.
    Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
    Wound healing is a complex and dynamic process that involves modifying the wound environment depending on the patient's health status. Scar formation depends on many factors that influence wound healing, are important to bear in mind because most of the negative factors involved can be stopped by implementing an adequate treatment. The consensus in wound therapy recommends dressings that should keep a moist and alkaline environment thus creating a protective barrier against mechanical stress and secondary infections, in view of promoting granulation. Read More

    Thromboprophylaxis in Elderly Surgical Patients: Current State and Future Considerations.
    Chirurgia (Bucur) 2017 Nov-Dec;112(6):664-672
    Venous thromboembolism is the number one cause of preventable death for hospital inpatients. Aging general surgical patients are especially susceptible to DVT/PE and this risk increases in the presence of other comorbidities prevalent in the elderly. However, it is often unrecognised and undertreated. Read More

    LEAK study: design of a nationwide randomised controlled trial to find the best way to treat wound leakage after primary hip and knee arthroplasty.
    BMJ Open 2017 12 28;7(12):e018673. Epub 2017 Dec 28.
    Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
    Introduction: Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are highly successful treatment modalities for advanced osteoarthritis. However, prolonged wound leakage after arthroplasty is linked to prosthetic joint infection (PJI), which is a potentially devastating complication. On the one hand, wound leakage is reported as a risk factor for PJI with a leaking wound acting as a for micro-organisms. Read More

    Diagnosis and management of peristomal pyoderma gangrenosum: A systematic review.
    J Am Acad Dermatol 2017 Dec 27. Epub 2017 Dec 27.
    Departments of Dermatology at the University of California, San Francisco, San Francisco, California. Electronic address:
    Background: Peristomal pyoderma gangrenosum (PPG) is an uncommon subtype of pyoderma gangrenosum. PPG is a challenging condition to diagnose and treat; no evidence-based guidelines exist.

    Objective: We sought to identify important clinical features of PPG and effective treatments available for its management. Read More

    Designing a pain management protocol for craniotomy: A narrative review and consideration of promising practices.
    Surg Neurol Int 2017 6;8:291. Epub 2017 Dec 6.
    Department of Anesthesiology and Perioperative Medicine, University of California Los Angeles, UCLA, Los Angeles, California, USA.
    Background: Craniotomy is a relatively common surgical procedure with a high incidence of postoperative pain. Development of standardized pain management and enhanced recovery after surgery (ERAS) protocols are necessary and crucial to optimize outcomes and patient satisfaction and reduce health care costs.

    Methods: This work is based upon a literature search of published manuscripts (between 1996 and 2017) from Pubmed, Cochrane Central Register, and Google Scholar. Read More

    Incisional Negative-Pressure Wound Therapy for Perineal Wounds After Abdominoperineal Resection for Rectal Cancer, a Pilot Study.
    Adv Wound Care (New Rochelle) 2017 Dec;6(12):425-429
    Department of Surgery, IJsselland Hospital, Capelle aan de IJssel, The Netherlands.
    Abdominoperineal resection (APR) is associated with high incidence of surgical wound infections. The use of incisional negative-pressure wound therapy (iNPWT) is known to reduce wound infections for several surgical indications. The aim of this pilot study was to investigate the potential of a new portable negative-pressure therapy device on perineal wound healing in patients undergoing APR. Read More

    Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial.
    Lancet Diabetes Endocrinol 2018 03 20;6(3):186-196. Epub 2017 Dec 20.
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.
    Background: Diabetic foot ulcers are serious and challenging wounds associated with high risk of infection and lower-limb amputation. Ulcers are deemed neuroischaemic if peripheral neuropathy and peripheral artery disease are both present. No satisfactory treatment for neuroischaemic ulcers currently exists, and no evidence supports one particular dressing. Read More

    Local Modalities for Preventing Surgical Site Infections: An Evidence-based Review.
    J Am Acad Orthop Surg 2018 Jan;26(1):14-25
    From the Department of Orthopaedic Surgery, Warren Alpert Medical School at Brown University, Rhode Island Hospital, Providence, RI.
    Surgical site infections remain a dreaded complication of orthopaedic surgery, affecting both patient economics and quality of life. It is important to note that infections are multifactorial, involving both surgical and patient factors. To decrease the occurrence of infections, surgeons frequently use local modalities, such as methicillin-resistant Staphylococcus aureus screening; preoperative bathing; intraoperative povidone-iodine lavage; and application of vancomycin powder, silver-impregnated dressings, and incisional negative-pressure wound therapy. Read More

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