9,179 results match your criteria Surgery of the Thymus Gland


Thymic lymphoid hyperplasia with Graves' disease in a 28-year-old female: a case report.

Gland Surg 2020 Apr;9(2):437-441

Department of Thoracic Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

Thymic lymphoid hyperplasia with Graves' disease (GD) is not uncommon in adults. Generally, cases are newly diagnosed with GD when they refer to the department of endocrinology in hospital, and an anterior mediastinal mass is found on a computed tomography scan by accident. Almost half of them receive thymectomy due to the concern about thymoma or thymic carcinoma. Read More

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http://dx.doi.org/10.21037/gs.2019.12.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225470PMC

Safety and effectiveness of reoperation for persistent or recurrent drug refractory secondary hyperparathyroidism.

Gland Surg 2020 Apr;9(2):401-408

Department of Thyroid and Breast Surgery, The Fifth Affiliated Hospital of Wenzhou Medical University & Lishui Hospital of Zhejiang University & Lishui Central Hospital, Lishui 323000, China.

Background: Drug-refractory secondary hyperparathyroidism (SHPT) is the most common complication in patients with chronic renal failure (CRF). Although surgery is the most effective and safe method for drug-refractory SHPT, the condition may persist or recur after the primary surgery, and reoperation is often required in these patients. The purpose of our current study was to evaluate the safety and effectiveness of reoperation for drug-refractory SHPT. Read More

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http://dx.doi.org/10.21037/gs-20-391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225451PMC

Trans-sternotomy versus video-assisted thoracic surgery for early-stage thymoma patients: a meta-analysis.

Gland Surg 2020 Apr;9(2):342-351

Department of Thoracic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Background: Over the years, video-assisted thoracic surgery (VATS) thymectomy has progressively replaced trans-sternotomy (TS) in early-stage thymoma (Masaoka stage I and stage II). This meta-analysis aimed to confirm the differences in the efficacies of VATS and TS approaches in early-stage thymoma patients.

Methods: A thorough literature search of the following online databases was performed: PubMed, Cochrane Library, Web of Science, and EMBASE. Read More

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http://dx.doi.org/10.21037/gs.2020.03.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225494PMC

Cystic thymic degeneration with pseudoepitheliomatous hyperplasia in a Beagle puppy: an idiopathic lesion?

J Vet Diagn Invest 2020 May 10;32(3):435-439. Epub 2020 Apr 10.

Department of Veterinary Medicine, University of Perugia, Perugia, Italy.

A 6-mo-old female Beagle dog was inappetent and depressed. The radiographic, ultrasonographic, and computed tomographic examination of the chest revealed a 10 × 7 cm multicystic mediastinal structure interpreted as altered thymus, in association with moderate pleural effusion that laboratory tests confirmed as hemothorax. No history of trauma or anticoagulant drug intoxication was reported, and no coagulation disorders were detected. Read More

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http://dx.doi.org/10.1177/1040638720914570DOI Listing

[Clinical Analysis of Primary Pulmonary Lymphoepithelioma-like Carcinoma in 8 Patients].

Zhongguo Fei Ai Za Zhi 2020 Mar;23(3):168-175

Department of Thoracic Medicine, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan Cancer Hospital, Changsha 410006, China.

Background: Lymphoepithelioma-like carcinoma, an uncommon epithelial tumor, is mostly originated form the nasopharynx and also occurs in foregut-derived organs, such as lung, stomach, salivary gland, and thymus. Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype accounting for around 0.9% of non-small cell lung cancer (NSCLC). Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2020.03.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118332PMC

Pediatric thyroid ultrasound: a radiologist's checklist.

Pediatr Radiol 2020 Apr 12;50(4):563-574. Epub 2020 Mar 12.

Radiology Department, University Hospital of Heraklion, Medical School, University of Crete, Stavrakia Voutes, 71110, Crete, Greece.

Ultrasonography (US) is the imaging method of choice for evaluating the pediatric thyroid gland, complemented by scintigraphy and thyroid function tests, especially when evaluating children with suspected congenital hypothyroidism, goiter, infectious or autoimmune diseases, or neoplasm. Diagnostic considerations in newborns with congenital hypothyroidism mainly include dysgenesis, dyshormonogenesis, transient hypothyroidism and central (hypophyseal) hypothyroidism. The midline of the neck should be scrutinized for thyroid tissue from the floor of the mouth to the thoracic inlet. Read More

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http://dx.doi.org/10.1007/s00247-019-04602-2DOI Listing

A cell atlas of human thymic development defines T cell repertoire formation.

Science 2020 02;367(6480)

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell census of the human thymus across the life span and to reconstruct T cell differentiation trajectories and T cell receptor (TCR) recombination kinetics. Using this approach, we identified and located in situ CD8αα T cell populations, thymic fibroblast subtypes, and activated dendritic cell states. Read More

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http://dx.doi.org/10.1126/science.aay3224DOI Listing
February 2020

A mutational profile in multiple thymic squamous cell carcinoma.

Gland Surg 2019 Dec;8(6):691-697

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Background: Multiple thymic squamous cell carcinoma (TSCC) is a rare thymic epithelial tumor with a dismal prognosis. Mutational profiles of multiple TSCC may expand our understanding of tumorigenesis and treatment options for these tumors.

Methods: We sequenced the whole exomes of 3 TSCC nodules from a multiple TSCC patient and a paired peripheral blood sample and identified single-nucleotide variants and small insertions and deletions, and also performed gene ontological and pathway analyses. Read More

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http://dx.doi.org/10.21037/gs.2019.11.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989891PMC
December 2019

Subxiphoid thymectomy with a double sternum retractor: a pilot study.

Gland Surg 2019 Dec;8(6):657-662

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.

Background: Our study aims to describe the experience of a single team in terms of the potential and benefits of subxiphoid thymectomy using a double sternum hook retractor.

Methods: From November 2016 to July 2018, 34 patients have been undergone subxiphoid thymectomy at our Department. Twenty patients were diagnosed with Masaoka Stage I-III thymomas, 12 with thymic hyperplasia or cysts of the thymus, 2 with thymic tumors. Read More

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http://dx.doi.org/10.21037/gs.2019.11.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989895PMC
December 2019

Epidermoid Thymic Cyst - A Very Rare Mediastinal Mass.

Rev Port Cir Cardiotorac Vasc 2019 Oct-Dec;26(4):267-268

Cardiothoracic Surgery, CUF Infante Santo Hospital, Lisbon, Portugal.

Objectives: Thymic cysts represent 1-3% of all tumors in the anterior mediastinum, but their knowledge is important during the differential diagnosis of a mediastinal mass.

Methods: We describe the case of a 52 years old woman, totally asymptomatic, with an incidental diagnosis of a mediastinal mass at thoracic computed tomography evaluation.

Results: Thoracic magnetic resonance showed an heterogeneous mass with approximately 3,6 cm, at the anterior mediastinum. Read More

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A novel reconstruction technique of a tracheal defect in the emergent setting using a thymus flap in a patient with tracheoinnominate artery fistula.

Surg Case Rep 2020 Jan 14;6(1):21. Epub 2020 Jan 14.

Division of Cardiothoracic Surgery, Department of Surgery, Icahn School of Medicine at Mount Sinai South Nassau, Oceanside, NY, USA.

Background: There is a very high mortality associated with a tracheoinnominate artery fistula; however, when patients survive, they often require reconstruction of the eroded tracheal defect after the bleeding has been controlled.

Case Presentation: This is the case of an 83-year-old male with a tracheoinnominate artery fistula who was stabilized in the operating room and underwent repair of his trachea. A novel technique of using the thymus gland as a pedicled flap to repair a large tracheal defect was executed after achieving hemostasis. Read More

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http://dx.doi.org/10.1186/s40792-019-0763-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960273PMC
January 2020

Predictors of post-thymectomy long-term neurological remission in thymomatous myasthenia gravis: an analysis from a multi-institutional database.

Eur J Cardiothorac Surg 2020 May;57(5):867-873

Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Objectives: Thymectomy is the treatment of choice for thymomatous myasthenia gravis (MG) for both oncological and neurological aspects. However, only a few studies comprising small numbers of patients have investigated post-thymectomy neurological outcomes. We examined post-thymectomy long-term neurological outcomes and predictors of thymomatous MG using a multi-institutional database. Read More

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http://dx.doi.org/10.1093/ejcts/ezz334DOI Listing

Thyroid Carcinoma Showing Thymus-Like Differentiation (CASTLE) with Tracheal Invasion: A Case Report.

Am J Case Rep 2019 Dec 10;20:1845-1851. Epub 2019 Dec 10.

Department of Surgery, The University of Hong Kong, Hong Kong, Hong Kong S.A.R., China (mainland).

BACKGROUND Thyroid carcinoma showing thymus-like differentiation (CASTLE) is a rare disease entity. It arises from ectopic thymic tissue in the thyroid gland. Patients usually present with enlarging neck mass and hoarseness. Read More

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http://dx.doi.org/10.12659/AJCR.919208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913266PMC
December 2019

Metcalf Lecture Award: Applying niche biology to engineer T-cell regenerative therapies.

Authors:
David T Scadden

Exp Hematol 2019 12 23;80:1-10. Epub 2019 Nov 23.

Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA. Electronic address:

The processes generating cells of adaptive immunity render them less amenable to the single cytokine signals used so effectively to regenerate myeloid cells. T-cell neogenesis begins in the bone marrow, where specific sets of late osteolineage cells govern the specification of hematopoietic cells capable of migrating to the thymus where differentiation is completed. Osteocalcin-expressing bone marrow stromal cells producing Dll4 serve as a progenitor niche enabling this T-competent cell production. Read More

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http://dx.doi.org/10.1016/j.exphem.2019.11.004DOI Listing
December 2019

Phytochemical Analysis and Assessment of Biological Properties of Essential Oils Obtained from Thyme and Rosmarinus Species.

Curr Pharm Biotechnol 2020 ;21(5):414-424

Laboratory of Cytogenetic, Molecular Biology and Biology of Reproduction, University of Tunis El-Manar, El-Manar, Tunisia.

Background: The plant species Thymus algeriensis (TA); Thymus capitatus (TC) and Rosmarinus officinalis (RO), are widely used in traditional medicine in Tunisia. The bioactivities of their essential oils have also been reported previously. The main objective of this work was to assess the phytochemical composition, the antioxidant activity, cytotoxic potential and the antibacterial, antifungal, of the essential oil (EO) of these plants. Read More

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http://dx.doi.org/10.2174/1389201020666191019124630DOI Listing
January 2020

Fusiform Cervical Mass in a 6-Year Old Boy; Do not Forget the Thymic Cyst.

Acta Medica (Hradec Kralove) 2019 ;62(3):117-122

First Department of Internal Medicine, General Hospital "Hippokration", Thessaloniki, Greece.

Cervical thymic cyst is a rare clinical entity, with approximately one hundred cases reported in the literature so far. The purpose of this case report is to highlight some certain features, along with an extensive research of the relevant literature. A 6-year-old boy was admitted to the Otorhinolaryngology Department due to the presence of a left-sided, painless, latero-cervical swelling, first observed by his parents 2 weeks ago. Read More

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http://dx.doi.org/10.14712/18059694.2019.135DOI Listing
April 2020
1 Read

Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.

Nat Immunol 2019 12 21;20(12):1644-1655. Epub 2019 Oct 21.

Gastroenterology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Invariant natural killer T (iNKT) cells recognize activating self and microbial lipids presented by CD1d. CD1d can also bind non-activating lipids, such as sphingomyelin. We hypothesized that these serve as endogenous regulators and investigated humans and mice deficient in acid sphingomyelinase (ASM), an enzyme that degrades sphingomyelin. Read More

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http://dx.doi.org/10.1038/s41590-019-0504-0DOI Listing
December 2019
1 Read

The Tumor-Immune Response Is Not Compromised by Mesenchymal Stromal Cells in Humanized Mice.

J Immunol 2019 11 2;203(10):2735-2745. Epub 2019 Oct 2.

Centre de Recherche, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec H3T 1C5, Canada;

Therapeutic uses of mesenchymal stromal cells (MSCs) have emerged over the past decade. Yet, their effect on tumor growth remains highly debated, particularly in an immune competent environment. In this study, we wanted to investigate the impact of human umbilical cord-derived MSCs (hUC-MSCs) on tumor growth in humanized mice generated by the human adoptive transfer of PBMCs or the cotransplantation of hematopoietic stem cells and human thymic tissue (human BLT [Hu-BLT]). Read More

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http://dx.doi.org/10.4049/jimmunol.1900807DOI Listing
November 2019

Update in diagnostic imaging of the thymus and anterior mediastinal masses.

Gland Surg 2019 Sep;8(Suppl 3):S188-S207

Department of Medicine, Surgery and Neuro Sciences, Diagnostic Imaging, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

Anterior mediastinal masses include a wide spectrum of malignant and benign pathologies with a large percentage represented by thymic lesions. Distinguishing these masses on diagnostic imaging is fundamental to guide the proper management for each patient. This review illustrates possibilities and limits of different imaging modalities to diagnose a lesion of the anterior mediastinum with particular attention to thymic disease. Read More

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http://dx.doi.org/10.21037/gs.2019.05.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755948PMC
September 2019
2 Reads

[Myasthenia gravis].

Nervenarzt 2019 Oct;90(10):1055-1066

Neurologische Klinik, Universitätsklinikum Würzburg, Josef Schneider Str. 11, 97080, Würzburg, Deutschland.

Myasthenia gravis (MG) is an autoimmune disorder caused by antibodies against acetylcholine receptors (AChR) or other structural proteins of the neuromuscular junction. This diminishes cholinergic transmission, thus leading to exercise-induced fatigue and sometimes manifest muscle weakness, including the bulbar and ocular musculature. Whereas ocular MG is as a rule initially symptomatically treated with acetylcholine esterase inhibitors, generalized MG requires long-term immunosuppression. Read More

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http://link.springer.com/10.1007/s00115-019-00798-8
Publisher Site
http://dx.doi.org/10.1007/s00115-019-00798-8DOI Listing
October 2019
3 Reads

Carcinoma Showing Thymus-Like Elements: A Rare Malignant Tumor of the Thyroid Gland.

P R Health Sci J 2019 09;38(3):192-195

Assistant Professor, Department of General Surgery, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey.

Carcinoma showing thymus-like elements (CASTLE) is a rare tumor arising in the thyroid gland. Fewer than 100 patients with this tumor, those predominantly from Eastern Asia, have been reported before. We present the first CASTLE case from Turkey. Read More

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September 2019
4 Reads

Challenges in diagnosing ectopic thymus tissue in children.

BMJ Case Rep 2019 Sep 17;12(9). Epub 2019 Sep 17.

Paediatrics, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.

The presentation of a fast-growing cervical mass necessitates prompt attention due to risk of the mass effect on vital structures and requires preferential screening for infections, bleeding and malignancies in an extensive list of differential diagnoses. This case report describes a 4.5-year-old boy with a fast-growing, unilateral lesion in the neck, with clinical features in keeping with malignant characteristics. Read More

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http://dx.doi.org/10.1136/bcr-2018-228807DOI Listing
September 2019
2 Reads

Insights into Thymus Development and Viral Thymic Infections.

Viruses 2019 Sep 9;11(9). Epub 2019 Sep 9.

Department of Experimental and Clinical Medicine, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.

T-cell development in the thymus is a complex and highly regulated process, involving a wide variety of cells and molecules which orchestrate thymocyte maturation into either CD4 or CD8 single-positive (SP) T cells. Here, we briefly review the process regulating T-cell differentiation, which includes the latest advances in this field. In particular, we highlight how, starting from a pool of hematopoietic stem cells in the bone marrow, the sequential action of transcriptional factors and cytokines dictates the proliferation, restriction of lineage potential, T-cell antigen receptors (TCR) gene rearrangements, and selection events on the T-cell progenitors, ultimately leading to the generation of mature T cells. Read More

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http://dx.doi.org/10.3390/v11090836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784209PMC
September 2019
2 Reads
3.279 Impact Factor

Class-switch recombination to IgA in the Peyer's patches requires natural thymus-derived Tregs and appears to be antigen independent.

Mucosal Immunol 2019 11 9;12(6):1268-1279. Epub 2019 Sep 9.

Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden.

Our understanding of how class-switch recombination (CSR) to IgA occurs in the gut is still incomplete. Earlier studies have indicated that Tregs are important for IgA CSR and these cells were thought to transform into follicular helper T cells (Tfh), responsible for germinal center formation in the Peyer's patches (PP). Following adoptive transfer of T-cell receptor-transgenic (TCR-Tg) CD4 T cells into nude mice, we unexpectedly found that oral immunization did not require an adjuvant to induce strong gut IgA and systemic IgG responses, suggesting an altered regulatory environment in the PP. Read More

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http://dx.doi.org/10.1038/s41385-019-0202-0DOI Listing
November 2019
1 Read

Pembrolizumab in a Patient With a Metastatic CASTLE Tumor of the Parotid.

Front Oncol 2019 14;9:734. Epub 2019 Aug 14.

Department of Internal Medicine, Hirslanden Klinik St. Anna, Lucerne, Switzerland.

Carcinoma showing thymus-like elements (CASTLE) is a rare tumor, most commonly found in the thyroid gland. Here we report a case of CASTLE tumor localized to the parotid gland, recognized in retrospect after a late manifestation of symptomatic pleural carcinomatosis. The original tumor in the parotid gland was treated by surgery followed by radiotherapy. Read More

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http://dx.doi.org/10.3389/fonc.2019.00734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702522PMC
August 2019
3 Reads

Ectopic cervical thymus in children: Clinical and radiographic features.

Laryngoscope 2019 Aug 28. Epub 2019 Aug 28.

Department of Otolaryngology, Head & Neck Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Objectives: Ectopic thymus is rare and can be a diagnostic challenge. This study evaluated the management of children radiographically diagnosed with ectopic cervical thymus.

Methods: A retrospective review of 100 patients was performed. Read More

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http://dx.doi.org/10.1002/lary.28248DOI Listing
August 2019
1 Read

Prevalence of Thymic Parathyroids in Primary Hyperparathyroidism During Radioguided Parathyroidectomy.

Clin Med Insights Endocrinol Diabetes 2019 14;12:1179551419869917. Epub 2019 Aug 14.

Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL, USA.

Background: Radioguided surgery has been an effective tool for identifying hyperfunctioning parathyroid glands during routine parathyroidectomy for hyperparathyroidism. The purpose of this study was to examine the role of radioguided surgery for the identification of intrathymic parathyroid glands.

Material And Methods: Between March 2001 and February 2018, 2291 patients underwent parathyroidectomy by 1 surgeon for primary hyperparathyroidism. Read More

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http://dx.doi.org/10.1177/1179551419869917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696833PMC
August 2019
1 Read

Rare concurrence of ectopic intrathyroidal parathyroid gland and papillary thyroid carcinoma within a thyroid lobe: A care-compliant case report.

Medicine (Baltimore) 2019 Aug;98(34):e16893

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

Rationale: The inferior parathyroid glands derive from the third branchial pouch and seldom ectopically migrate to thyroid grand, mediastinum, thymus. Ectopic intrathyroidal parathyroid grand (ETPG) is rare and it cannot be consistently detected by any imaging examinations. The unusual ETPG is easily resected during thyroidectomy, which might cause postoperative hypoparathyroidism. Read More

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http://dx.doi.org/10.1097/MD.0000000000016893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716706PMC
August 2019
2 Reads

Potentially actionable FGFR2 high-level amplification in thymic sebaceous carcinoma.

Virchows Arch 2020 Feb 10;476(2):323-327. Epub 2019 Aug 10.

Institute of Pathology, University Medical Centre Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Our aim was to investigate sebaceous differentiation in thymus tumours and to identify new actionable genomic alterations. To this end we screened 35 normal and 23 hyperplastic thymuses, 127 thymomas and 41 thymic carcinomas for the presence of sebaceous differentiation as defined by morphology and expression of adipophilin and androgen receptor (AR). One primary thymic carcinoma showed morphology of sebaceous carcinomas (keratinizing and foam cells, calcifications, giant cells), a strong expression of adipophilin and AR together with squamous markers. Read More

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http://dx.doi.org/10.1007/s00428-019-02644-3DOI Listing
February 2020
4 Reads

Therapeutic targeting of Notch signaling and immune checkpoint blockade in a spontaneous, genetically heterogeneous mouse model of T-cell acute lymphoblastic leukemia.

Dis Model Mech 2019 09 16;12(9). Epub 2019 Sep 16.

Regeneron Pharmaceuticals, Inc., Tarrytown, New York, NY 10591, USA

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer derived from the malignant transformation of T-cell progenitors. Outcomes remain poor for T-ALL patients who have either primary resistance to standard-of-care chemotherapy or disease relapse. Notably, there are currently no targeted therapies available in T-ALL. Read More

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http://dx.doi.org/10.1242/dmm.040931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765191PMC
September 2019
5 Reads

Dedifferentiated liposarcoma of the thyroid gland: A case report.

Mol Clin Oncol 2019 Sep 18;11(3):219-224. Epub 2019 Jun 18.

Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

Liposarcoma is one of the most common soft tissue tumors that affect adults. Liposarcoma is typically identified in the retroperitoneum, trunk and extremities as a slow-growing mass, yet is rare in the thyroid gland. Herein, we report a case of dedifferentiated liposarcoma that developed in the thyroid gland, and performed a literature review. Read More

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http://dx.doi.org/10.3892/mco.2019.1882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636207PMC
September 2019
3 Reads

Rewiring regulatory T cells for tumour killing.

Nat Biomed Eng 2019 10;3(10):766-767

Departments of Surgery and Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/s41551-019-0443-yDOI Listing
October 2019

B Cell-Mediated Antigen Presentation through MHC Class II Is Dispensable for Atherosclerosis Progression.

Immunohorizons 2019 01 21;3(1):37-44. Epub 2019 Jan 21.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110; and

Depletion of B cells attenuates plaque development and modulates T cell responses in mouse models of atherosclerosis, suggesting that Ag presentation by B cells may promote disease progression. Thus, we set out to determine the role of B cell-mediated MHC class II (MHC II) Ag presentation during atherosclerotic plaque development. We developed murine conditional MHC II deletion and expression systems under control of the B cell-restricted CD19 promoter in an experimental model of atherosclerosis. Read More

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http://dx.doi.org/10.4049/immunohorizons.1800015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999615PMC
January 2019

The Value of CT and MRI for Determining Thymoma in Patients With Myasthenia Gravis.

Cancer Control 2019 Jan-Dec;26(1):1073274819865281

2 National Cancer Hospital, Ha Dong, Hanoi, Vietnam.

The aim of the study was to evaluate the usefulness of computed tomography (CT) and magnetic resonance imaging (MRI) for differentiating thymoma from nonthymoma abnormalities in patients with myasthenia gravis (MG). A cross-sectional study of 53 patients with MG, who had undergone surgical thymectomy, was conducted at 103 Hospital (Hanoi, Vietnam) and Cho Ray Hospital (Ho Chi Minh City, Vietnam) during August 2014 and January 2017. The CT and MRI images of patients with MG were qualitatively and quantitatively (radiodensity and chemical shift ratio [CSR]) analyzed to determine and compare their ability to distinguish thymoma from nonthymoma abnormalities. Read More

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http://dx.doi.org/10.1177/1073274819865281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651671PMC
January 2020

Recognition of Ultrasound Artifact Mimicking Pulmonary Artery Dissection in Patients with Heart Disease.

Biomed Res Int 2019 19;2019:4919416. Epub 2019 Jun 19.

Department of Echocardiography, Fuwai Hospital, National Center for Cardiovascular Diseases, China.

Purpose: Imaging artifacts are frequently encountered when performing clinical echocardiography. Based on our review of the literature, two-dimensional linear artifacts are mainly reported in the ascending aorta in patients with suspected aortic dissections. However, pulmonary artery artifacts that mimic pulmonary artery dissection have not been discussed. Read More

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http://dx.doi.org/10.1155/2019/4919416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607705PMC
December 2019
4 Reads

Ectopic Thymus: An Unusual Case of Subglottic Mass.

Ann Otol Rhinol Laryngol 2019 Dec 18;128(12):1182-1188. Epub 2019 Jul 18.

Pediatric Airway Team Unit, Giannina Gaslini Research Institute and Children Hospital, Genoa, Italy.

Objectives: The aim of our study is to report a case of a child with subglottic thymus that was suspected during diagnostic work-up for severe airway obstruction, excised surgically and confirmed with final histopathological examination. Moreover, we performed a narrative literature review to outline clinical and diagnostic features of this rare condition and to report suggestions for the management of subglottic masses.

Methods: We report the case of a 7-month-old boy who was admitted to our Pediatric Airway Team Unit due to a history of worsening biphasic stridor and recurrent episodes of upper airway obstruction. Read More

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http://dx.doi.org/10.1177/0003489419863828DOI Listing
December 2019

Ectopic hamartomatous thymoma in an immunocompromised male.

Pathol Res Pract 2019 Sep 10;215(9):152497. Epub 2019 Jun 10.

Northwestern University, 303 E Chicago Ave Ward 3-140 W127, Chicago, 60611, United States.

Ectopic hamartomatous thymoma (EHT) is a rare benign neoplasm classically occurring in the lower neck of adult males. Here we present a case of EHT occurring in a 43-year-old immunocompromised male and a brief review of existing literature. The patient presented with a palpable mass overlying the left clavicle which, on imaging, showed a solitary nodule possibly eroding the cortical bone. Read More

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http://dx.doi.org/10.1016/j.prp.2019.152497DOI Listing
September 2019
11 Reads

Spindle Epithelial Tumor of Thymus-like Differentiation (SETTLE) in a 3-year-old African girl.

Clin Case Rep 2019 Jun 25;7(6):1119-1122. Epub 2019 Apr 25.

Department of Pathology, Faculty of Medicine Kuwait University Kuwait City Kuwait.

Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a rare tumor of the thyroid gland occurring in children and young adults. This report presents SETTLE as a tumor that can also affect young children (under fives). Although majority of the reports were in Caucasians, the tumor can affect all races. Read More

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http://dx.doi.org/10.1002/ccr3.2163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553348PMC
June 2019
7 Reads

Gender-Related Effect of Sodium Dichloroacetate on the Number of Hassall's Corpuscles and RNA NKCC1 Expression in Rat Thymus.

Biomed Res Int 2019 24;2019:1602895. Epub 2019 Apr 24.

Department of Histology and Embryology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LT 44307, Lithuania.

The aim was to investigate the effect of dichloroacetate (DCA) on thymus weight, Hassall's corpuscle number (HCs), and NKCC1 RNA expression in Wistar rats aged 4-5 weeks. They were investigated in the controls and DCA-treated gonad-intact and castrated males and females. The treatment lasted 4 weeks with DCA 200 mg/kg/day. Read More

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http://dx.doi.org/10.1155/2019/1602895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507237PMC
November 2019
1 Read

Cervical Thymic Cyst Around Hypoglossal Nerve.

J Craniofac Surg 2019 Jun;30(4):e295-e297

Department of Pathology, Ataturk University, Erzurum, Turkey.

Cervical thymic cyst is rare lesions leading to cervical mass. As it is a rare entity, it might be confused with other congenital neck masses or neoplastic lesions. Preoperative diagnosis is almost impossible. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005155DOI Listing
June 2019
7 Reads

Long-term survival and differentiation of human thymocytes in human thymus-grafted immunodeficient mice.

Immunotherapy 2019 07 29;11(10):881-888. Epub 2019 May 29.

Key Laboratory of Organ Regeneration & Transplantation of Ministry of Education, The First Hospital of Jilin University, Changchun, 130061, PR China.

Thymus transplants have produced encouraging clinical outcomes in achieving thymopoiesis and T-cell development. This study was aimed to investigate whether human thymus contains self-renewing lymphoid progenitors capable of maintaining long-term T-cell development. Immunodeficient mice were transplanted with human thymic tissue along with autologous GFP-expressing or allogeneic CD34 cells and followed for human thymopoiesis and T-cell development from the thymic progenitors versus CD34 cells, which can be distinguished by GFP or HLA expression. Read More

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http://dx.doi.org/10.2217/imt-2019-0030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949514PMC
July 2019
1 Read

Comparison of biological features between severely immuno-deficient NOD/Shi-scid Il2rg and NOD/LtSz-scid Il2rg mice.

Exp Anim 2019 Nov 21;68(4):471-482. Epub 2019 May 21.

BoZo Research Center Inc., Tsukuba Research Institute, 8 Okubo, Tsukuba, Ibaraki 300-2611, Japan.

Biological background data up to 11 weeks of age and tumorigenic susceptibility to xenotransplantation with HeLa cells were compared between severely immuno-deficient NOG and NSG mice. The body weight was lower in NOG mice than in NSG mice. Severe depletion of peripheral blood lymphocytes and lymphoid hypoplasia that are well-known characteristics of these mice were equally observed. Read More

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http://dx.doi.org/10.1538/expanim.19-0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842799PMC
November 2019
6 Reads

Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes.

Nat Commun 2019 05 21;10(1):2244. Epub 2019 May 21.

Department of Organ Fabrication, Keio University School of Medicine, Tokyo, Japan.

Before they are used in the clinical setting, the effectiveness of artificially produced human-derived tissue-engineered medical products should be verified in an immunodeficient animal model, such as severe combined immunodeficient mice. However, small animal models are not sufficient to evaluate large-sized products for human use. Thus, an immunodeficient large animal model is necessary in order to properly evaluate the clinical efficacy of human-derived tissue-engineered products, such as artificial grafts. Read More

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http://dx.doi.org/10.1038/s41467-019-10107-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529409PMC
May 2019
4 Reads

Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance.

Nat Commun 2019 05 17;10(1):2220. Epub 2019 May 17.

Department of Molecular Biosciences, Institute of Cellular and Molecular Biology, The University of Texas at Austin, 100 E. 24th Street A5000, Austin, TX, 78712, USA.

Both medullary thymic epithelial cells (mTEC) and dendritic cells (DC) present tissue-restricted antigens (TRA) to thymocytes to induce central tolerance, but the relative contributions of these antigen-presenting cell (APC) subsets remain unresolved. Here we developed a two-photon microscopy approach to observe thymocytes interacting with intact APCs presenting TRAs. We find that mTECs and DCs cooperate extensively to induce tolerance, with their relative contributions regulated by the cellular form of the TRA and the class of major histocompatibility complex (MHC) on which antigen is presented. Read More

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http://dx.doi.org/10.1038/s41467-019-09727-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525199PMC
May 2019
4 Reads

Antimicrobial Effect of and var. as Raw Extracts and Nanovesicles.

Pharmaceutics 2019 May 14;11(5). Epub 2019 May 14.

Department of Medicine, Surgery and Experimental Science, University of Sassari, 07100, Sassari, Italy.

In view of the increasing interest in natural antimicrobial molecules, this study screened the ability of (TC) essential oil and var. (CLP) extract as raw extracts or incorporated in vesicular nanocarriers against and . After fingerprint, TC or CLP were mixed with lecithin and water to produce liposomes, or different ratios of water/glycerol or water/propylene glycol (PG) to produce glycerosomes and penetration enhancer vesicles (PEVs), respectively. Read More

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http://dx.doi.org/10.3390/pharmaceutics11050234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572595PMC
May 2019
7 Reads

EWSR1 translocation in primary hyalinising clear cell carcinoma of the thymus.

Histopathology 2019 Sep 19;75(3):431-436. Epub 2019 Jul 19.

Institute of Pathology, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany.

Aims: In thymic carcinomas, focal clear cell change is a frequent finding. In addition to a prominent, diffuse clear cell morphology, some of these carcinomas show an exuberant hyalinised extracellular matrix, and therefore probably represent a separate entity. However, a characteristic genomic alteration remains elusive. Read More

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http://dx.doi.org/10.1111/his.13890DOI Listing
September 2019
23 Reads
3.453 Impact Factor

Interaction of neurotransmitters and neurochemicals with lymphocytes.

J Neuroimmunol 2019 07 11;332:99-111. Epub 2019 Apr 11.

The University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, Brisbane, Australia; Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia. Electronic address:

Neurotransmitters and neurochemicals can act on lymphocytes by binding to receptors expressed by lymphocytes. This review describes lymphocyte expression of receptors for a selection of neurotransmitters and neurochemicals, the anatomical locations where lymphocytes can interact with neurotransmitters, and the effects of the neurotransmitters on lymphocyte function. Implications for health and disease are also discussed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728193008
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http://dx.doi.org/10.1016/j.jneuroim.2019.04.006DOI Listing
July 2019
18 Reads

Chest wall thickness and depth to vital structures in paediatric patients - implications for prehospital needle decompression of tension pneumothorax.

Scand J Trauma Resusc Emerg Med 2019 Apr 16;27(1):45. Epub 2019 Apr 16.

Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Background: Recommendations regarding decompression of tension pneumothorax in small children are scarce and mainly transferred from the adult literature without existing evidence for the paediatric population. This CT-based study evaluates chest wall thickness, width of the intercostal space (ICS) and risk of injury to vital structures by needle decompression in children.

Methods: Chest wall thickness, width of the intercostal space and depth to vital structures were measured and evaluated at 2nd ICS midclavicular (MCL) line and 4th ICS anterior axillary line (AAL) on both sides of the thorax using computed tomography (CT) in 139 children in three different age groups (0, 5, 10 years). Read More

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http://dx.doi.org/10.1186/s13049-019-0623-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469218PMC
April 2019
3 Reads

Effect of Chitosan Nanoparticle-Loaded on Hydrogen Peroxide-Induced Bone Marrow Stromal Cell Damage.

Stem Cells Int 2019 26;2019:5142518. Epub 2019 Feb 26.

Tissue Engineering Group (TEG), National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, Lembah Pantai, 50603 Kuala Lumpur, Malaysia.

We have determined the protective effects of (TS) extract and nanoparticle-loaded TS on hydrogen peroxide-induced cell death of mesenchymal stromal cells (MSCs) . Gas chromatography-mass spectroscopy confirmed the spectrum of active components in the extract. Out of the three different extracts, the hexane extract showed significant free radical scavenging activity. Read More

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http://dx.doi.org/10.1155/2019/5142518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431441PMC
February 2019
4 Reads

Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice.

Life Sci Alliance 2019 04 1;2(2). Epub 2019 Apr 1.

Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

The immune system encompasses acquired and innate immunity that matures through interaction with microenvironmental components. Cytokines serve as environmental factors that foster functional maturation of immune cells. Although NOD/SCID/IL2rgKO (NSG) humanized mice support investigation of human immunity in vivo, a species barrier between human immune cells and the mouse microenvironment limits human acquired as well as innate immune function. Read More

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http://dx.doi.org/10.26508/lsa.201800195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445396PMC
April 2019
18 Reads