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BMC Med Genomics 2022 Jun 20;15(1):140. Epub 2022 Jun 20.

Department of Joint and Sport Medicine, Tianjin Union Medical Center, Nankai University Affiliated People's Hospital, Jieyuan Road 190, Hongqiao District, Tianjin, 300121, People's Republic of China.

Background: This study aimed to identify the differentially expressed mRNAs and lncRNAs in inflammatory long head of biceps tendon (LHBT) of rotator cuff tear (RCT) patients and further explore the function and potential targets of differentially expressed lncRNAs in biceps tendon pathology.

Methods: Human gene expression microarray was made between 3 inflammatory LHBT samples and 3 normal LHBT samples from RCT patients. GO analysis and KEGG pathway analysis were performed to annotate the function of differentially expressed mRNAs. Read More

S D Med 2022 Apr;75(4):166-169

Sanford Radiology, Sioux Falls, South Dakota.

Acute calcific tendinitis (ACT) is a relatively uncommon disorder that can involve the hand and wrist. ACT is frequently misdiagnosed due to a lack of familiarity with the condition and the clinical presentation that can be confused with other conditions. We report a case of acute calcific tendinitis of the flexor carpi ulnaris (FCU) tendon in a 68-year-old woman. Read More

J Sports Med Phys Fitness 2022 Jun 10. Epub 2022 Jun 10.

School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Background: Rotator cuff tendinopathy (RCTe) is the most common cause of pain and shoulder dysfunction. Numerous clinical studies have demonstrated the therapeutic capacity of exogenous peritendinous hyaluronic acid (HA), and the effectiveness of Extracorporeal Shockwaves Therapy (ESWT) in reducing pain. The aim of this study is to evaluate the added effects of HA treatment plus ESWT (E-g) or ESWT alone (SC-g), focusing on reduction of self-reported pain and disability of patients with RCTe. Read More

Disabil Rehabil 2022 Jun 9:1-10. Epub 2022 Jun 9.

Physiotherapy Department, Laboratory of Advanced Physiotherapy (LAdPhys), School of Health and Care Sciences, University of West Attica, Aigaleo, Greece.

Purpose: We aimed to translate and cross-culturally adapt the Western Ontario Rotator Cuff index into Greek (WORC-GR) and evaluate its reliability and validity in a Greek speaking population with rotator cuff (RC) disorders.

Materials And Methods: Translation and cross-cultural adaptation process followed published guidelines. Content and face validity were assessed by 9 experts and 16 patients with RC pathologies, respectively. Read More

Radiol Clin North Am 2022 Jul 20;60(4):583-592. Epub 2022 May 20.

Department of Radiology, Centre Hospitalier de l'Université de Montréal (CHUM), 1000 Rue Saint-Denis, Montreal, Quebec H2X 0C1, Canada. Electronic address:

Aging changes tendon biology, healing capacity, and biomechanical properties and results in increased susceptibility to injuries. With the aging population, the socio-economic burden from tendinopathies is increasing. This article discusses the structure of tendons and the physiologic changes that occur with aging. Read More

Am J Sports Med 2022 Jun 6:3635465221098133. Epub 2022 Jun 6.

Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Background: Degenerative rotator cuff tendinopathy (RCT) is associated with the senescence of tendon-derived stem cells (TDSCs). Nonsteroidal anti-inflammatory drugs have been demonstrated to alleviate age-associated inflammation (inflamm-aging)-induced cellular senescence of skeletal stem/progenitor cells. However, whether they can alleviate degenerative RCT through reducing inflamm-aging-related TDSC senescence is still unknown. Read More

Lasers Med Sci 2022 Jun 1. Epub 2022 Jun 1.

Institute of Biomedical Engineering, Anhembi Morumbi University (UAM), Estrada Dr. Altino Bondensan 500, Distrito de Eugênio de Melo, CEP: 12.247-016, São José dos Campos, SP, Brazil.

This study aimed to compare shoulder tendinopathy treatment with therapeutic ultrasound combined with LED photobiomodulation therapy using LED-infrared (850 nm) or LED-red (640 nm). The study assessed 75 patients, aged 45 to 70 years, distributed into five experimental groups (15 patients each): therapeutic ultrasound (US), infrared light irradiation (IR), visible red light irradiation (VR), infrared light and ultrasound combined (IR-US), and red light in conjunction with ultrasound (VR-US). The ultrasound parameters are 1 MHz, 0. Read More

Int J Environ Res Public Health 2022 05 11;19(10). Epub 2022 May 11.

Spasticity and Movement Disorders "ReSTaRt" Unit, Physical Medicine and Rehabilitation Section, OORR Hospital, University of Foggia, 71122 Foggia, Italy.

Calcific tendinopathy of the shoulder (CTS) is the most common cause of shoulder pain. Conservative treatment is considered as the first therapeutic choice for CTS. The main objective of this study was to assess the effect of US-guided needling (UGN) compared to UGN plus Biocompatible Electrical Neurostimulation (BEN) in the treatment of the CTS. Read More

Front Sports Act Living 2022 25;4:879860. Epub 2022 Apr 25.

Aberdeen City Council, Aberdeen, United Kingdom.

Objective: To identify current evidence on blood flow restriction training (BFRT) in tendon injuries and healthy tendons, evaluating physiological tendon effects, intervention parameters, and outcomes.

Methods: This scoping review was reported in accordance with the PRISMA Extension for Scoping Reviews (PRISMA-ScR). Databases searched included MEDLINE, CINAHL, AMED, EMBase, SPORTDiscus, Cochrane library (Controlled trials, Systematic reviews), and five trial registries. Read More

Clin J Sport Med 2022 Apr 22. Epub 2022 Apr 22.

Department of Orthopedics and Rehabilitation, Tufts University, Medford, Massachusetts; and.

Objective: The purpose of this study was to compare a traditional barbotage technique with percutaneous ultrasonic barbotage (PUB) for the treatment of rotator cuff (RC) calcific tendinopathy.

Design: Three-year retrospective review.

Setting: Participants aged 18 to 75 presenting at 2 highly specialized outpatient orthopedic referral centers with symptomatic RC calcific tendinopathy. Read More

Pak J Med Sci 2022 Mar-Apr;38(3Part-I):565-569

Gulsah Yasa Ozturk, MD. Physical Medicine and Rehabilitation Department, University of Health Sciences, Adana City Hospital Adana, Turkey.

Objectives: To investigate the effect of 1% procaine injection, which is used in neural therapy, on shoulder pain and dysfunction in patients diagnosed with supraspinatus tendinopathy.

Methods: The Range of Motion values, Visual Analog Scale and the QuickDASH Scale scores of 70 patients, who were diagnosed with musculus supraspinatus tendinitis based on magnetic resonance imaging findings, were analyzed. The data of the scales obtained before neural therapy and at the follow-up visit at four weeks after the end of therapy were compared, and a p-value of <0. Read More

J Shoulder Elbow Surg 2022 Apr 21. Epub 2022 Apr 21.

University of Texas at Austin, Austin, TX, USA.

Background: Population-based studies have established that most people develop rotator cuff tendinopathy during their lifetime, it is often accommodated, and there is limited correspondence between symptom intensity and pathology severity. To test the relationship between effective accommodation and mental health on its continuum, we studied the relative association of magnitude of capability with symptoms of anxiety or depression compared to quantifications of rotator cuff pathology such as defect size, degree of retraction, and muscle atrophy among people presenting for specialty care.

Methods: We analyzed a retrospective cohort of 71 adults seeking specialty care for symptoms of rotator cuff tendinopathy, that had a recent Magnetic Resonance Imaging (MRI) of the shoulder, and completed the following questionnaires: PROMIS Global Health (a measure of symptom intensity and magnitude of capability, consisting of the mental and physical Health subscores), the Generalized Anxiety Disorder (symptoms of anxiety), and the Patient Health Questionnaire (symptoms of depression). Read More

Comput Intell Neurosci 2022 11;2022:8978878. Epub 2022 Apr 11.

Department of Spine Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China.

Background: Symptomatic rotator cuff calcific tendinitis (RCCT) is a common shoulder disorder, and approaches combined with artificial intelligence greatly facilitate the development of clinical practice. Current scarce knowledge of the onset suggests that clinicians may need to explore this disease thoroughly.

Methods: Clinical data were retrospectively collected from subjects diagnosed with RCCT at our institution within the period 2008 to 2020. Read More

J Shoulder Elbow Surg 2022 Apr 14. Epub 2022 Apr 14.

Orthopedic Soft Tissue Research Program, Hospital for Special Surgery, New York, NY, USA. Electronic address:

Background: Subacromial impingement of the rotator cuff caused by variations in acromial anatomy or altered glenohumeral kinematics leads to inflammation and degeneration of the rotator cuff, ultimately contributing to the development of tendinopathy. However, the underlying cellular and molecular changes in the impinged tendon remain poorly understood. Since the rat is an accepted model for rotator cuff studies, we have developed a rat model to study rotator cuff tendinopathy. Read More

Clin Radiol 2022 06 12;77(6):e442-e448. Epub 2022 Apr 12.

Duke-NUS Medical School, Singapore; Department of Diagnostic Radiology, Division of Radiological Sciences, Singapore General Hospital, Singapore.

Aims: To determine the prevalence of neovascularity in the supraspinatus tendon of patients presenting with clinically painful unilateral rotator cuff tendinopathy (RCT) using conventional colour Doppler ultrasound (CDU), power Doppler ultrasound (PDU), and superb microvascular imaging (SMI). The association between Doppler findings and clinical scores was also assessed.

Methods: The bilateral supraspinatus of consecutive patients presented with unilateral RCT clinically were evaluated with grey-scale ultrasound (tendon thickening, heterogeneous echotexture, and hypoechogenicity), CDU, PDU, and SMI. Read More

J Spinal Cord Med 2022 Apr 14:1-11. Epub 2022 Apr 14.

Division of Health Care Delivery Research, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA.

Objective: To investigate the progression of rotator cuff tendon pathology across one year in manual wheelchair (MWC) users with spinal cord injury (SCI) and matched able-bodied individuals, and to explore the association between pain, age, and duration of wheelchair use with the progression of rotator cuff pathology.

Design: Longitudinal cohort study, 1-year follow-up.

Setting: Outpatient clinic at a tertiary medical center. Read More

J Exp Orthop 2022 Apr 8;9(1):31. Epub 2022 Apr 8.

Orthopaedics biotechnology Lab, IRCCS Istituto Ortopedico Galeazzi, Via Riccardo Galeazzi 4, 20161, Milan, Italy.

Purpose: The aim of this systematic review is to explore the current available knowledge about tendon disorders and orthobiologics derived by preclinical experiments to evaluate their role and efficacy in the different stages and conditions related to the tendon healing processes.

Methods: The systematic review was performed according to the PRISMA guidelines. Different electronic databases (MEDLINE, Web of Science, EMBASE) were searched for studies investigating orthobiologics (PRP and cell-based products from adipose tissue or bone marrow) in animal models or veterinary clinical trials for tendon pathologies (complete/partial tendon ruptures, rotator cuff tears, tendinopathy, enthesis-related injuries). Read More

Skeletal Radiol 2022 Apr 2. Epub 2022 Apr 2.

Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Emilia-Romagna, Italy.

Rationale And Objectives: While ultrasound-guided percutaneous irrigation for painful calcific tendinopathy (US-PICT) is the treatment of choice for the rotator cuff, there is a lack of knowledge regarding the treatment of this condition with atypical location. The purpose of our study is to assess if US-PICT can be applied safely and successfully in atypical sites, outside of the rotator cuff.

Materials And Methods: We retrospectively reviewed the US-PICT performed outside the rotator cuff, in the last 5 years in a single institution. Read More

Clin Orthop Relat Res 2022 Jul 23;480(7):1251-1258. Epub 2022 Mar 23.

Department of Surgery and Perioperative Care, Dell Medical School, the University of Texas at Austin, Austin, TX, USA.

Background: Claims of shoulder injury now account for half of all claims to the Vaccine Injury Compensation Program. Reports from databases of claims or potential adverse events note a relatively high mean age and high prevalences of rotator cuff tendinopathy and adhesive capsulitis-common shoulder problems that might be incidental to vaccination. Published case reports provide much more detail about individual patients than is available in databases. Read More

Orthop J Sports Med 2022 Mar 15;10(3):23259671221084706. Epub 2022 Mar 15.

Bone and Joint Research Center, Chang Gung Memorial Hospital, Linkou.

Background: Rotator cuff (RC) tendinopathy is one of the most common causes of shoulder pain. Platelet-rich plasma (PRP) has been frequently used in clinical scenarios, but its efficacy remains inconsistent.

Purpose: To investigate the different responses of human tenocytes from torn RCs to leukocyte-rich PRP (LR-PRP) and leukocyte-poor PRP (LP-PRP) in a 2-chamber coculture device. Read More

J Comput Assist Tomogr 2022 Mar-Apr 01;46(2):219-223

From the Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ.

Objective: This study aimed to investigate the effect of calcific tendinosis on the diagnosis of rotator cuff tears (RCTs) on magnetic resonance imaging (MRI) and magnetic resonance arthrography (MRA).

Materials And Methods: Calcific tendinosis was confirmed radiographically. Two musculoskeletal radiologists then retrospectively and independently reviewed the MRI/MRA examinations, with surgery or arthroscopy performed within 90 days of the MRI. Read More

Acta Diabetol 2022 Jul 15;59(7):871-883. Epub 2022 Mar 15.

Department of Internal Medicine, Faculty of Medicine and Health Sciences, Alneelain University, Khartoum, Sudan.

Tendino-myopathy, an unexplored niche, is a non-vascular unstated T2DM complication, which is largely disregarded in clinical practice, thus, we aim to explore it in this review. Literature search using published data from different online resources. Epidemiologically, reported prevalence varies around 10-90%, which is marked variable and unreliable. Read More

Biomed Res Int 2022 4;2022:1230857. Epub 2022 Mar 4.

University of Lahore, University Institute of Physical Therapy, Lahore, Pakistan.

Objective: The current trial was designed to evaluate the effects of high-energy shockwave therapy on objective and subjective outcomes among participants with calcified rotator cuff tendinopathy.

Methods: This parallel-group, randomized trial consists of 42 patients affected by calcific tendinopathies divided into two groups of 21 participants. Patients having calcified tendinopathy aged between 30 and 65 years with type A or B calcification were selected in the trial after signing the written consent form. Read More

Pol J Radiol 2022 13;87:e87-e92. Epub 2022 Feb 13.

Clinica di Radiologia EOC IIMSI, Lugano, Switzerland.

Rotator cuff calcific tendinopathy is a common condition caused by the presence of calcification into the rotator cuff or in the subacromial-subdeltoid bursa. The pathogenetic mechanism of this pathology is still debated. Calcific tendinitis frequently affects the rotator cuff and may cause shoulder pain and reduction of range of motion. Read More

J Orthop Res 2022 Mar 10. Epub 2022 Mar 10.

Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

Rotator cuff tendinopathy, a major cause of shoulder disability, occurs due to trauma or degeneration. Our molecular understanding of traumatic and degenerative tears remains elusive. Here, we probed transcript level differences between traumatic and degenerative tears. Read More

Arthroscopy 2022 03;38(3):716-718

Vail, Colorado.

The critical shoulder angle (CSA) reflects the lateral extent of the acromion and the inclination of the glenoid. In 2013, CSA was first introduced and its association with rotator cuff (RC) tears and glenohumeral osteoarthritis (GHOA) was shown. It was speculated that with a high CSA, there was an increased superior force vector from the deltoid and that this superior force led to RC tears. Read More

Curr Sports Med Rep 2022 Mar;21(3):78-83

Department of Family Medicine and Community Health, University of Florida, Gainesville, FL.

Abstract: Shoulder injury related to vaccine administration (SIRVA), an entity that causes acute shoulder pain and may limit range of motion (ROM) after vaccination, is a condition where a small but significant percentage of patients are experiencing in light of the current push for mass immunizations against SARS-CoV-2 worldwide. A search of literature related to SIRVA was performed across multiple electronic databases. Women, patients reporting vaccine injection location to be too high, and patients without prior history of shoulder pain were the most common historical factors in those experiencing SIRVA. Read More

Front Mol Biosci 2021 15;8:787008. Epub 2022 Feb 15.

School of Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

Rotator cuff tendinopathy (RCT) is the most common cause of shoulder pain, therefore posing an important clinical problem. Understanding the mechanism and biochemical changes of RCT would be of crucial importance and pave the path to targeting novel and effective therapeutic strategies in translational perspectives and clinical practices. Phosphorylation, as one of the most important and well-studied post-translational modifications, is tightly associated with protein activity and protein functional regulation. Read More

Orthop J Sports Med 2022 Feb 24;10(2):23259671221078806. Epub 2022 Feb 24.

Department of Radiology, Faculty of Medicine, Thammasat University, Khlong Nueng, Thailand.

Background: Os acromiale is an anatomic variant in which the acromial ossification center fails to fuse. It may lead to painful shoulder conditions and surgical intervention may be required for treatment. The prevalence of os acromiale in South Koreans (0. Read More

Cureus 2022 Jan 23;14(1):e21529. Epub 2022 Jan 23.

Department of Family Practice, University of British Columbia, North Vancouver, CAN.

Lifelong, pregnancy-induced low back pain forced me to search for solutions to the problem of pain. Currently, low back pain is often diagnosed as "nonspecific" and, as a result, a multitude of tests and poorly effective, at times side effect-laden or habit-forming treatments are recommended. My quest for relief took me to first diagnose my pain as coming from the sacroiliac joints, then to prolotherapy, the first treatment which brought me prolonged relief. Read More