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J Med Invest 2021 ;68(1.2):154-158

Department of Otolaryngology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.

To predict occult nodal metastasis in clinical N0 patients with tongue cancer, we developed combined index (CI) : SUVmax of the largest lymph node in PET / CT by weighting coefficient plus its maximum minor axis (< 10 mm) in contrast-enhanced CT (CECT). In this retrospective study, 57 clinical N0 patients with tongue cancer, who underwent elective supraomohyoid neck dissection at cervical levels of I-III were enrolled. The cutoff value of SUVmax of 2. Read More

Medicine (Baltimore) 2021 Feb;100(7):e24806

Department of Oral and Maxillofacial Surgery, Iwata City Hospital, Iwata.

Rationale: Oral cancer often causes secondary primary cancers in the upper gastrointestinal tract. However, there are no reports of secondary primary cancers in patients with oral squamous cell carcinoma and malignant lymphoma of the small intestine. This report describes a case of metachronous multiple primary cancers of the tongue and small intestine malignant lymphoma. Read More

J Dent Sci 2020 Dec 7;15(4):519-525. Epub 2020 Jun 7.

Department of Oral and Maxillofacial Surgery, Mackay Memorial Hospital, Taipei, Taiwan.

Background/purpose: The status of neck lymph nodes (LNs) plays an important role in survival of oral cavity cancer. Early stage oral cancer patients are still at a risk for locoregional metastasis. We aimed to determine the number of LNs that needs to be retrieved for adequate diagnosis and treatment of the neck tumor. Read More

Gan To Kagaku Ryoho 2020 Dec;47(13):1890-1892

Dept. of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine.

Surgical ablation and reconstruction are the first-line treatment strategies for squamous cell carcinoma of the tongue. However, locally advanced cases can be complicated by postoperative dysphagia. Here, we report a case of advanced tongue cancer in a very elderly patient who regained good swallowing function following a reconstructive surgery using a pectoralis major musculocutaneous flap with elevation of the hyoid bone. Read More

Am J Transl Res 2020 15;12(12):8030-8039. Epub 2020 Dec 15.

Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine Shanghai 200011, China.

Purpose: To identify the significance of level IIb neck dissection for patients with clinically node-negative oral squamous cell carcinoma (OSCC).

Methods: A retrospective study was conducted with 203 patients with OSCC with no palpable lymph nodes in neck admitted to the Department of Oral Maxillofacial-Head and Neck Oncology from January 2012 through December 2014. After the diagnostic evaluations, all patients underwent wide local dissection and periodic supraomohyoid neck dissection (SOHND). Read More

Oral Maxillofac Surg 2021 Mar 23;25(1):127-132. Epub 2020 Aug 23.

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki, 305-8575, Japan.

We report a rare case of lymph node metastasis of papillary thyroid cancer (PTC) incidentally detected in a neck dissection specimen of tongue squamous cell carcinoma (SCC). A 42-year-old Japanese woman was diagnosed with tongue SCC (T1N0M0, Stage I). Partial glossectomy with supraomohyoid neck dissection was performed under general anesthesia, and histopathological examinations revealed primary SCC of the tongue and neck metastasis of PTC in neck dissection specimens. Read More

Med J Malaysia 2020 07;75(4):450-451

Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Department of Pathology Anatomy, Indonesia.

Metastatic cervical cancers to the oral cavity are uncommon. These metastases most commonly present as lesions of the jaw bones and the mandible. A 57-year-old female patient complained of mass lesion in her oral cavity after definitive treatment for squamous cell carcinoma of the cervix stage IIIB. Read More

J Surg Educ 2021 Jan-Feb;78(1):214-231. Epub 2020 Jul 6.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

Objectives: YouTube has become the preferred resource for trainees in otolaryngology to prepare for surgery. This study aimed to compare the evaluation by 2 attending physicians and 2 resident physicians of the quality of videos on YouTube on neck dissection, a key indicator case in head and neck surgery. The authors aimed to assess the quality and quantity of YouTube videos available for development of a virtual surgical educational curriculum for trainees in otolaryngology. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Oct 13;130(4):363-372. Epub 2020 Jun 13.

Department of Otolaryngology Head and Neck Surgery, Galilee Medical Center, affiliated with Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel. Electronic address:

Objective: The purpose of our systematic review was to investigate the prevalence of level IV involvement and skip metastases in patients with clinically negative neck (cN0) oral tongue squamous cell carcinoma (OTSCC). The occurrence of occult metastases to lower levels in the neck (levels IV and V) or the development of an erratic distribution of cervical metastases ("skip metastases") that bypass the upper neck levels (levels I to III) and go directly to level IV or V challenges the role of supraomohyoid neck dissection in the treatment of OTSCC; therefore, controversy exists over including level IV cervical nodes during an elective neck dissection of OTSCC.

Study Design: Our search included all studies published from 1989 until January 2018 in the Cochrane Library, PubMed, EMBASE, and Web of Science. Read More

BMC Oral Health 2020 04 16;20(1):113. Epub 2020 Apr 16.

Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Southern Medical University, 366 south of Jiangnan Road, Guangzhou, 510280, China.

Background: Myxofibrosarcoma (MFS) is a soft tissue sarcoma that commonly occurs in late adult life. It is mainly located in the subcutaneous soft tissues of extremities characterized by a high recurrence rate at the original site. MFS of the head and neck is rare, while it occurs in the maxilla and mandible is extremely rare. Read More

Int J Clin Oncol 2020 Jun 5;25(6):1067-1071. Epub 2020 Mar 5.

Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: No clear consensus has been reached on the indication of supraomohyoid neck dissection (SOHND) for clinically positive lymph-node metastasis.

Patients: Consecutive 100 patients with previously untreated oral cancer treated at Kobe University Hospital were included in this study. All patients were clinically staged as anyTN1M0 and underwent radical dissection of the primary site and level I-V neck dissection as the initial treatment. Read More

Case Rep Hematol 2019 23;2019:6015803. Epub 2019 Nov 23.

Department of Oral and Maxillofacial Surgery, Okazaki City Hospital, Okazaki, Japan.

Peripheral blood stem cell transplantation (PBSCT) has increasingly been used for hematologic cancer therapy, resulting in improved survival rates. However, risks include graft-versus-host disease (GVHD) and secondary solid tumors. Here, we describe a case of tongue squamous cell carcinoma (SCC) complicated by bronchiolitis obliterans (BO) following PBSCT. Read More

J Craniomaxillofac Surg 2019 Dec 29;47(12):1963-1967. Epub 2019 Nov 29.

Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Oral and Maxillofacial Surgery, Germany. Electronic address:

Introduction: Neck dissection is an essential component of oral cancer therapy. Based on a standardised approach to cervical lymph node management, we seek to define the relevance of neck dissection extension in cN + cases.

Material And Methods: A retrospective analysis from January 2009 to February 2017 identified 84 patients with oral squamous cell carcinoma with a cN + neck or histologically proven lymph node involvement in intraoperative frozen sectioning and who received modified radical neck dissection according to the presented neck dissection algorithm. Read More

JAMA Otolaryngol Head Neck Surg 2020 01;146(1):85

Department of Head and Neck Oncology, HCG Cancer Centre, Bangalore, India.

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Sep;54(9):628-631

Department of Oral and Maxillofacial Surgery, General Hospital of Chinese PLA, Beijing 100853, China.

To explore the feasibility of using da Vinci Surgical System to perform supraomohyoid neck dissection (SOND) to avoid visible scar and reduce trauma. Between September 2017 and December 2018, twenty patients (two females and 18 males, mean age, 54.8 years) with oral cancer treated in the Department of Stomatology, Hainan Hospital of General Hospital of Chinese PLA were enrolled in this study. Read More

Zhonghua Yi Xue Za Zhi 2019 Aug;99(32):2516-2520

Department of Oral Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266555, China.

To evaluate the clinical effects of functional neck dissection (FND) and supraomohyoid neck dissection (SOND) in patients with cN0/N1 oral squamous cell carcinoma (OSCC). A total of 210 patients with stage cN0/N1 OSCC underwent FND and SOND between January 2012 and May 2015 were retrospectively reviewed, among which, 147 patients were male and 63 were female, with an age range of 23-82 years and mean age of (62.2±10. Read More

J Maxillofac Oral Surg 2019 Sep 15;18(3):428-431. Epub 2018 May 15.

1Department of Surgical Oncology, King George's Medical University, Lucknow, India.

Introduction: Abundant blood supply of tongue permits various flap designs and makes it a good choice for reconstructing defects following resection of oral cancer.

Aim: We aim to evaluate the reliability of tongue flap for small- and medium-size defects after resection of oral cancer in terms of viability, complications, and functional outcome.

Methods: In this retrospective analysis, patients reconstructed with lateral tongue flaps after resection of oral cavity carcinoma from May 2011 to December 2017 were included. Read More

J Maxillofac Oral Surg 2019 Sep 9;18(3):360-365. Epub 2018 Oct 9.

1SDM Craniofacial Surgery and Research Centre, SDM College of Dental Science and Hospital, Dharwad, Karnataka India.

Purpose: The objective of this study was to assess the accessibility in the resection of maxillary tumours, resection margin status, and morbidity following maxillectomy through lip split with paramedian mandibulotomy approach.

Materials And Methods: A retrospective review of 20 consecutive patients who underwent maxillectomy with resection of primary tumours through lip split mandibulotomy approach with supraomohyoid neck dissection for maxillary tumours between 2008 and 2016. Patients details including the tumours site, extension and neck node involvement. Read More

J Cancer Res Ther 2019 Jul-Sep;15(3):737-738

Consultant Pediatrician, CSI Kalyani Multispeciality Hospital, Mylapore, Chennai, Tamil Nadu, India.

In the modern era, there is an increase in the incidence of double malignancies owing to the remarkable improvement in cancer diagnostics and patient survival. Double malignancies can be either synchronous or metachronous. Synchronous double malignancy can present either at the same time or within 6 months of diagnosis of the first one. Read More

JAMA Otolaryngol Head Neck Surg 2019 06;145(6):542-548

Department of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Importance: The rate of skip metastasis to neck level IV in patients with clinically node-negative neck (cN0) oral cavity squamous cell carcinoma (OCSCC) remains controversial.

Objective: To provide a high level of evidence using a meta-analysis on the rate of skip metastasis to level IV in this subset of patients.

Data Sources: The Embase, PubMed, and Google Scholar databases were searched for articles published during the period of January 1, 1970, through December 31, 2017, using the following key terms: neck dissection, N0 neck, squamous cell carcinoma, skip metastasis, radical neck dissection, lymph node management, neck metastasis, oral cavity cancer, and tongue cancer. Read More

J Oral Maxillofac Surg 2019 Oct 27;77(10):2154-2167. Epub 2019 Mar 27.

Professor, Department of Head and Neck Oncology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China.

Purpose: Whether elective neck dissection (END) should be adopted for patients with clinically early-stage (cT1-2N0M0) oral cavity squamous cell carcinoma (OCSCC) remains debated. The aim of this systematic review was to compare the survival benefit of END with that of the wait-and-watch policy (WW) for patients with early-stage OCSCC based on survival data.

Materials And Methods: According to the inclusion criteria, an exhaustive search for eligible studies was conducted. Read More

Clin Med Insights Oncol 2019 2;13:1179554919838254. Epub 2019 Apr 2.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of New Mexico Hospital, UNM School of Medicine, Albuquerque, NM, USA.

Background: Myoepithelial cell carcinoma is a rare malignant neoplasm of salivary gland origin that typically presents in the parotid gland and minor salivary glands. It has been described previously in head and neck sites such as buccal mucosa, alveolar ridge, and base of tongue.

Methods: A 55-year-old man presented with 30 years of right-sided tongue pain and 10 years of gradually worsening ulceration. Read More

Craniomaxillofac Trauma Reconstr 2019 Mar 27;12(1):8-13. Epub 2018 Aug 27.

Cirugia Oral y Maxilofacial, Hospital Universitario Virgen de las Nieves, Granada, Andalucia, Spain.

The main aim of the present report is to study the pattern of distribution of cervical metastasis in buccal mucosa cancer and to discuss the various therapeutic options available. Fifty-three patients with squamous cell carcinoma of the buccal mucosa treated with tumorectomy and selective neck dissection were included in the study. We also studied the relationship between specific pathological features and overall survival. Read More

J Otolaryngol Head Neck Surg 2019 Feb 4;48(1). Epub 2019 Feb 4.

Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.

Background: Malignancies occur in approximately 1:1000 pregnancies; the most common being breast (46%) and hematological (18%) malignancies. Oral cancers account for only 2% of all cancers in pregnant women, and there are no standard guidelines for the treatment of oral cancer during pregnancy.

Methods: Between 2007 and 2014, our department managed 1109 patients with oral cancers; four (0. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2135-2137

Dept. of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine.

Leeches have been used for medical treatment for at least 2,500 years. Plastic surgeons have recently begun to use leeches to reduce venous congestion after flap reconstruction. However, few reports of leech use in the oral region have been published. Read More

Cochrane Database Syst Rev 2018 12 24;12:CD006205. Epub 2018 Dec 24.

School of Dentistry, The University of Western Australia, 17 Monash Avenue, Nedlands, Western Australia, Australia, 6009.

Background: Surgery is an important part of the management of oral cavity cancer with regard to both the removal of the primary tumour and removal of lymph nodes in the neck. Surgery is less frequently used in oropharyngeal cancer. Surgery alone may be treatment for early-stage disease or surgery may be used in combination with radiotherapy, chemotherapy and immunotherapy/biotherapy. Read More

Int J Surg Pathol 2019 May 27;27(3):305-310. Epub 2018 Nov 27.

1 Aichi Gakuin University, Nagoya, Japan.

Adenoid cystic carcinoma is one of the most common salivary gland malignancies with poor long-term prognosis, but the coexistence of sialoliths is extraordinarily rare. In this article, we report a case of 30-year-old woman with a history of submandibular area swelling with intermittent pain increasing during mealtimes that had led her attending physician to diagnose a sialolith in the left submandibular gland on a radiograph 10 years before. However, the surgical specimen proved to be an adenoid cystic carcinoma accompanied with a sialolith. Read More

Curr Probl Cancer 2019 08 12;43(4):336-343. Epub 2018 Nov 12.

Hospital Virgen de las Nieves, Granada, Spain.

Purpose: The main aim of the present study is to analyze the behavior of squamous cell carcinoma (SCC) of maxillary gingiva, alveolus, and hard palate and to determine the utility of selective neck dissection in clinically N0 patients at early stages.

Material And Method: Twenty-nine previously untreated patients with SCC of maxillary gingiva, alveolus, and hard palate were diagnosed and treated with at least a tumorectomy and selective neck dissection at HUVN and included in the study.

Results: A total of 34. Read More

World J Surg Oncol 2018 Nov 8;16(1):219. Epub 2018 Nov 8.

Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, India.

Background: The lymphatic spread from the cancers of the oral cavity follows an orderly progression and involvement of lower nodes without involvement of upper nodes and skip metastasis is rare. Selective neck dissections are increasingly being performed for node-positive patients; however, in node-negative patients the options of wait and watch, prophylactic radiotherapy, and prophylactic elective node dissections are debated. Quality of life and shoulder functions are important to choose the appropriate therapeutic modality. Read More

Ned Tijdschr Tandheelkd 2018 Oct;125(10):517-523

A 48-year-old man was referred for an evaluation of deviations in the pigmentation of the lower lip, intra-oral swelling and persistent numbness of the sensory area of the left mental nerve. In 2011, the diagnosis lentigo maligna of the lower lip was missed by histopathology of a biopsy performed elsewhere. In 2016, the numbness of the lower lip and chin was diagnosed by a neurologist as numb chin of unknown cause. Read More