2,157 results match your criteria Supraglottic Cancer


Multiple nonmelanocytic skin cancers in multiple regions.

Arch Craniofac Surg 2020 Jun 29;21(3):188-192. Epub 2020 Jun 29.

Department of Plastic and Reconstructive Surgery, Konkuk University Chungju Hospital, Konkuk University School of Medicine, Chungju, Korea.

The most common forms of nonmelanocytic skin cancer (NMSC) are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The growing incidence of skin cancer in the Republic of Korea has sparked increasing scientific interest in these types of tumors. In the case described herein, multiple NMSCs occurred asynchronously in various areas of the body in a single patient. Read More

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http://dx.doi.org/10.7181/acfs.2020.00073DOI Listing

Occult Metastasis in Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

Ann Otol Rhinol Laryngol 2020 Jul 1:3489420937744. Epub 2020 Jul 1.

Department of Otolaryngology-Head and Neck Surgery, Medical College of Georgia at Augusta University, Augusta, GA, USA.

Objective: The incidence of occult metastasis (OM) in laryngeal squamous cell carcinoma (SCC) is still widely debated. In this systematic review, we aim to determine the rate of OM in laryngeal SCC, its impact on recurrence, and the role of elective neck dissection (END) in the management of the clinically negative neck.

Methods: A systematic review of the English-language literature in Web of Science, PubMed, MEDLINE, and Cochrane Library databases on occult metastasis in laryngeal SCC from 1977 to 2018 was conducted. Read More

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http://dx.doi.org/10.1177/0003489420937744DOI Listing

Predictors for failure of supraglottic superimposed high frequency jet ventilation during endoscopic upper airway surgery in pediatric patients.

Paediatr Anaesth 2020 Jun 21. Epub 2020 Jun 21.

Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Airway surgery in pediatric patients is challenging with regard to balancing surgical exposure with ventilation requirements, as during the procedure the airway must be shared between laryngologist and anesthetist. For endoscopic laryngeal surgery, different methods of ventilation are used, among others jet ventilation via a specifically adapted suspension laryngoscope using a dual jet stream(Supraglottic Superimposed High Frequency Jet ventilation, SSHFJV) (1).High BMI and a history of pulmonary pathology proved to be factors contributing to failing of SSHFJV in adult patients (2). Read More

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http://dx.doi.org/10.1111/pan.13952DOI Listing

Transoral robotic surgery in head and neck district: a retrospective study on 67 patients treated in a single center.

Infect Agent Cancer 2020 15;15:40. Epub 2020 Jun 15.

Maxillofacial & ENT surgery Unit, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", via M. Semmola, Naples, Italy.

Background: The anatomical complexity of the oropharynx and the difficulty in reaching its distal portion have always conditioned the surgical accessibility.Robotic surgery represents an excellent alternative in the treatment of cervico-facial oncological diseases.

Methods: This series comprises all patients managed for head and neck cancer by Trans Oral Robotic Surgery TORS. Read More

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http://dx.doi.org/10.1186/s13027-020-00306-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296635PMC

Surgical, clinical and functional outcomes of transoral robotic surgery for supraglottic laryngeal cancers: A systematic review.

Oral Oncol 2020 Jun 10;109:104848. Epub 2020 Jun 10.

Robotic Surgery Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), France; Department of Otolaryngology-Head Neck Surgery, Foch Hospital, UFR Simone Veil, University Versailles Saint-Quentin-en Yvelines (University Paris Saclay), Paris, France.

Background: The aim of this systematic review is to shed light the current indications and outcomes of transoral robotic surgery (TORS) supraglottic laryngectomy (SGL) in patients with supraglottic laryngeal cancer.

Methods: PubMed, Scopus and Cochrane Library were searched by three independent otolaryngologists from the Young Otolaryngologists of IFOS for studies investigating the indications, effectiveness and safety of TORS SGL. Surgical, functional, and survival outcomes have been investigated. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104848DOI Listing

The nonsurgical management of early stage (T1/2 N0 M0) laryngeal cancer: A population analysis.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Jul 30;130(1):18-24. Epub 2020 May 30.

Clinical Professor, Department of Oral and Maxillofacial Surgery, University of Pennsylvania, Philadelphia, PA, USA; Private Practice, Brockton Oral and Maxillofacial Surgery Inc., Department of Oral and Maxillofacial Surgery, Good Samaritan Medical Center, Brockton, MA, USA.

Background: The purpose of this study was to evaluate the patterns of care and survival in the nonsurgical management of early-stage (T1/2 N0 M0) laryngeal cancer.

Study Design: This was a retrospective cohort study using data from the Surveillance, Epidemiology, and End Results (SEER) database during the period 2004 to 2015. Patients diagnosed with T1/2 N0 M0 laryngeal SCC definitively treated without surgery were included. Read More

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http://dx.doi.org/10.1016/j.oooo.2020.01.006DOI Listing

Is postoperative radiotherapy routinely indicated after total laryngectomy for pT3N0-1 supraglottic carcinoma?

Oral Oncol 2020 May 30:104825. Epub 2020 May 30.

Department of Otolaryngology Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2020.104825DOI Listing

Mode of Presentation of Laryngeal Cancer: A Single Radiotherapy Institute Experience in Iraq.

Gulf J Oncolog 2020 May;1(33):51-57

Radiation Oncology, Together for Cancer Control, Edmonton, Alberta, Canada.

Purpose: Laryngeal cancer is relatively common and usually presents with hoarseness due to a lesion in the glottis. We noticed that many of our patients had presented with supraglottic lesions and we could not find local literature in support of this observation. Mode of presentation and site of the lesion of these patients will be addressed in this review. Read More

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Meta-analysis of risk of occult lymph node metastasis in the irradiated, clinically N0 neck.

Head Neck 2020 May 19. Epub 2020 May 19.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, California, USA.

Background: Recurrent head and neck squamous cell carcinoma (HNSCC) after radiation is associated with poor survival, and management of the clinically negative (N0) neck during salvage surgery is controversial.

Methods: Studies were selected according to preferred reporting items for systematic reviews and meta-analyses guidelines. Inclusion criteria were patients with HNSCC, prior radiation to the lateral neck nodal basin, undergoing salvage surgery for local recurrence, persistence or second primary, and N0 at time of salvage. Read More

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http://dx.doi.org/10.1002/hed.26248DOI Listing

Expression and prognostic significance of YAP, TAZ, TEAD4 and p73 in human laryngeal cancer.

Histol Histopathol 2020 May 7:18228. Epub 2020 May 7.

Department of Anatomy, Histology and Embryology, University of Patras School of Medicine, Patras, Greece.

Objectives: The Hippo signaling pathway plays a critical role in organ size control and tissue homeostasis and its perturbation is associated with tumorigenesis. YAP (Yes associated protein) and TAZ (transcriptional co-activator with PDZ- binding motif) are the major nuclear effectors of the Hippo pathway interacting with TEADs (TEA domain) and p73 transcriptional factors to regulate gene expression. Altered expression of the above proteins promotes tumor initiation, progression and metastasis in a variety of cancer types. Read More

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http://dx.doi.org/10.14670/HH-18-228DOI Listing

Trans-Oral Robotic Surgery in the Management of a Supraglottic Solitary Fibrous Tumor.

J Craniofac Surg 2020 Jul-Aug;31(5):e491-e493

Otorhinolaryngology Unit, IRCCS Humanitas Clinical and Research Center, Rozzano.

Trans-oral robotic surgery (TORS) has become increasingly widespread for the head and neck surgery procedures. In this paper, the authors describe the first reported TORS in the management of a laryngeal solitary fibrous tumor (SFT). A 77-year-old woman suffered from progressive dysphonia lasting 2 years and occasional dyspnea. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006555DOI Listing

Incidence of Occult Lymph Node Metastasis in Primary Larynx Squamous Cell Carcinoma, by Subsite, T Classification and Neck Level: A Systematic Review.

Cancers (Basel) 2020 Apr 24;12(4). Epub 2020 Apr 24.

International Head and Neck Scientific Group, 35100 Padua, Italy.

Background: Larynx cancer is a common site for tumors of the upper aerodigestive tract. In cases with a clinically negative neck, the indications for an elective neck treatment are still debated. The objective is to define the prevalence of occult metastasis based on the subsite of the primary tumor, T classification and neck node levels involved. Read More

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http://dx.doi.org/10.3390/cancers12041059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225965PMC

Which risk factors are associated with stomal recurrence after total laryngectomy for laryngeal cancer? A meta-analysis of the last 30 years.

Braz J Otorhinolaryngol 2020 Apr 11. Epub 2020 Apr 11.

Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Department of Head and Neck Surgery, Liaoning Province, People's Republic of China. Electronic address:

Introduction: Stomal recurrence is a troublesome complication after total laryngectomy Despite a large number of studies having been performed, there is still controversy about which risk factors are most significant for the development of stomal recurrence.

Objective: The objective of the present meta-analysis was to analyze the potential factors leading to stomal recurrence after total laryngectomy.

Methods: PubMed, Web of Science, Cochrane Library, and Ovid databases were systematically searched using multiple search terms. Read More

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http://dx.doi.org/10.1016/j.bjorl.2020.03.002DOI Listing

Establishment and characterization of patient-derived xenografts as paraclinical models for head and neck cancer.

BMC Cancer 2020 Apr 15;20(1):316. Epub 2020 Apr 15.

Yonsei Cancer Center, Division of Medical Oncology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South Korea.

Background: We investigated whether head and neck squamous cell carcinoma (HNSCC) patient-derived xenografts (PDXs) reaffirm patient responses to anti-cancer therapeutics.

Methods: Tumors from HNSCC patients were transplanted into immunodeficient mice and propagated via subsequent implantation. We evaluated established PDXs by histology, genomic profiling, and in vivo anti-cancer efficacy testing to confirm them as the authentic in vivo platform. Read More

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http://dx.doi.org/10.1186/s12885-020-06786-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160896PMC

High pATM is Associated With Poor Local Control in Supraglottic Cancer Treated With Radiotherapy.

Laryngoscope 2020 Apr 10. Epub 2020 Apr 10.

Department of Otorhinolaryngology/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Objectives: Most early stage laryngeal squamous cell carcinomas (LSCC) are treated with radiotherapy. Discovery of new biomarkers are needed to improve prediction of outcome after radiotherapy and to identify potential targets for systemic targeted therapy. The ataxia telangiectasia mutated (ATM) gene plays a critical role in DNA damage response induced by ionizing radiation. Read More

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http://dx.doi.org/10.1002/lary.28641DOI Listing

Tonic-clonic seizures as first symptom of a disseminated supraglottic laryngeal cancer.

BMJ Case Rep 2020 Mar 22;13(3). Epub 2020 Mar 22.

Department of Clinical Oncology, Aalborg Universitetshospital, Aalborg, Denmark.

A 60-year-old man was found unconscious at work, without any signs of trauma. At the site, he presented with tonic-clonic seizures, central facial palsy and eye deviation. A CT scan of the cerebrum did not find bleeding or thrombosis, but contrast enhancement at the superior sagittal sinus and pathological cervical lymph nodes. Read More

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http://dx.doi.org/10.1136/bcr-2019-233584DOI Listing

Oncological and Surgical Outcomes of Patients Treated by Transoral CO Laser Cordectomy for Early-Stage Glottic Squamous Cell Carcinoma: A Retrospective Chart Review.

Ear Nose Throat J 2020 Mar 23:145561320911486. Epub 2020 Mar 23.

Department of Otolaryngology-Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.

Objective: To investigate the feasibility and the outcomes of transoral laser CO microsurgery (TLM) for resection of early-stage squamous cell carcinoma (SCC) of the vocal folds through several additional surgical procedures and tips improving the glottic exposure.

Methods: Retrospective chart review of patients treated by TLM cordectomy in a single European University Hospital for early-stage vocal fold SCCs (Tis, T1a, T1b, and T2). The following TLM outcomes were studied regarding the tumor size (Tis and T1a vs T1b and T2) and the margin status (negative vs positive/suspicious): patient position; type of laryngoscope; requirement to external counter pressure; resection of supraglottic structures (eg, ventricular band, epiglottic petiole, and suprahyoid epiglottis); pre- and postoperative complications; overall survival; disease-specific survival (DSS); and disease-free survival (DFS). Read More

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http://dx.doi.org/10.1177/0145561320911486DOI Listing

Clinical and dosimetric risk stratification for patients at high-risk of feeding tube use during definitive IMRT for head and neck cancer.

Tech Innov Patient Support Radiat Oncol 2020 Jun 28;14:1-10. Epub 2020 Feb 28.

Department of Radiation Oncology, Olivia Newton John Cancer Wellness & Research Centre, Austin Health, Heidelberg, Victoria, Australia.

Introduction: To identify organs to which dose limitation using intensity modulated radiotherapy (IMRT) can potentially modify the incidence and duration of feeding tube use, during and immediately following therapy for head and neck cancer.

Materials And Methods: One hundred and fourteen patients treated with definitive IMRT (± concurrent chemotherapy) head and neck mucosal cancers were included. Patients received a prophylactic feeding tube and followed up by a dietician for at least eight weeks post-radiotherapy. Read More

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http://dx.doi.org/10.1016/j.tipsro.2020.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052527PMC

Impact of supraglottic device with assist ventilation under general anesthesia combined with nerve block in uniportal video-assisted thoracoscopic surgery.

Medicine (Baltimore) 2020 Mar;99(10):e19240

Institute of Cancer and Basic Medicine (ICBM).

Background: With the improvement of anesthesia and surgical techniques, supraglottic device with assist ventilation under general anesthesia (GA) combined with nerve block is gradually applied to video-assisted thoracoscopic surgery. However, the safety of assist ventilation has not been fully confirmed, and a large number of samples should be studied in clinical exploration.

Methods: The subjects included 120 patients, undergoing elective thoracoscopic GA, with American Society of Anesthesiologists (ASA) physical status I or II, were randomly divided into 3 groups, 40 cases in each group. Read More

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http://dx.doi.org/10.1097/MD.0000000000019240DOI Listing

Dose Reduction to the Swallowing Apparatus and the Salivary Glands by De-Intensification of Postoperative Radiotherapy in Patients with Head and Neck Cancer: First (Treatment Planning) Results of the Prospective Multicenter DIREKHT Trial.

Cancers (Basel) 2020 Feb 26;12(3). Epub 2020 Feb 26.

Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.

Aim: Evaluating radiotherapy treatment plans of the prospective DIREKHT trial (ClinicalTrials.gov, NCT02528955) investigating de-intensification of radiotherapy in patients with head and neck cancer.

Patients And Methods: The first 30 patients from the DIREKHT trial of the leading study centre were included in this analysis. Read More

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http://dx.doi.org/10.3390/cancers12030538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139715PMC
February 2020

Laryngeal Candidiasis Mimicking Supraglottic Carcinoma by Prolonged Inhaled Steroid Therapy: A Case Report and Review of the Literature.

Ear Nose Throat J 2020 Feb 28:145561320907166. Epub 2020 Feb 28.

Dipartimento di Chirurgia Generale e Specialistica, Università "Luigi Vanvitelli" di Napoli, Napoli, Italy.

Candidiasis is a rare entity reported as an isolated and primary laryngeal disease. In this condition, inhaled steroids were the single most common predisposing factor. Also mycotic infections of larynx are frequently seen in patients with immune insufficiency, although they have also been reported in individual with normal immune status. Read More

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http://dx.doi.org/10.1177/0145561320907166DOI Listing
February 2020

Imaging checklist for preoperative evaluation of laryngeal tumors to be treated by transoral microsurgery: guidelines from the European Laryngological Society.

Eur Arch Otorhinolaryngol 2020 Jun 27;277(6):1707-1714. Epub 2020 Feb 27.

Department of Otorhinolaryngology, Maxillofacial and Thyroid Surgery, Fondazione IRCCS, National Cancer Institute of Milan, University of Milan, Milan, Italy.

Introduction: The modern availability in daily practice of different DICOM viewers allows physicians to routinely evaluate computed tomography (CT) and magnetic resonance (MR) scans of patients in the pre-, intra-, and postoperative settings. Their systematic use, together with a close surgeon-radiologist cooperation, may greatly improve outcomes of patients to be treated by transoral microsurgery for laryngeal cancer.

Materials And Methods: We herein propose guidelines for systematic evaluation of CT/MR images taken from patients affected by supraglottic and glottic cancer to be treated by transoral microsurgery. Read More

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http://dx.doi.org/10.1007/s00405-020-05869-0DOI Listing

Demographic and Tumor Characteristic Impact on Laryngeal Cancer Outcomes in a Minority Underserved Patient Population.

Otolaryngol Head Neck Surg 2020 Jun 25;162(6):888-896. Epub 2020 Feb 25.

Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA.

Objective: Advanced laryngeal squamous cell carcinoma remains associated with approximately 50% mortality at 5 years. Delivery of multimodality treatment remains critical to maximizing survival for this disease, but achieving this at a national level remains a difficult undertaking, particularly in under- and uninsured patients as well as minority patients. We sought to evaluate laryngeal cancer treatment delivery and clinical outcomes in a predominantly minority and underserved cohort of largely under- and uninsured patients in a county hospital. Read More

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http://dx.doi.org/10.1177/0194599820907064DOI Listing

[EARLY LARYNGEAL CANCER - TREATMENT OUTCOMES OF TRANSORAL LASER MICROSURGERY].

Harefuah 2020 Feb;159(1):77-82

Department of Otolaryngology Head and Neck Surgery, Carmel Medical Center, Haifa, Israel.

Aims: To evaluate predictive factors for local control, larynx preservation and overall survival in patients with early laryngeal cancer, who were treated with endoscopic transoral CO2 laser microsurgery.

Background: Transoral laser microsurgery (TLM) is the treatment of choice for early laryngeal cancer. The current study aimed to assess the outcomes and validity of carbon dioxide (CO2) laser microsurgery in patients with early larynx cancer and to determine predictors for outcomes. Read More

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February 2020

Surgical nodal management in hypopharyngeal and laryngeal cancer.

Eur Arch Otorhinolaryngol 2020 May 11;277(5):1481-1489. Epub 2020 Feb 11.

Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Centre Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.

Objective: The aim of this study is to compare pre-therapeutic staging of the loco-regional lymphatic basin and subsequent surgical management in cN0 versus cN+ hypopharyngeal and laryngeal cancer patients.

Methods: We analyzed all hypopharyngeal and laryngeal carcinoma patients treated surgically at a single quaternary medical care and cancer center between 2004 and 2014. We established two groups for patients who underwent neck dissection comparing patients with a low LNR (lymph node ratio) to one with a high LNR. Read More

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http://dx.doi.org/10.1007/s00405-020-05838-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160213PMC

Phonatory compensation in patients with larynx cancer after CO2 laser cordectomy.

Otolaryngol Pol 2019 Oct;74(2):31-35

Zakład Fonoaudiologii Klinicznej i Logopedii, Uniwersytet Medyczny w Białymstoku.

Introduction: CO2 laser endoscopic cordectomy is the method of laryngeal cancer treatment. The type of cordectomy (I-VI) depends on the extent of the tumor. Endoscopic laser surgery provides more satisfactory phonation conditions in comparison to open surgical procedures. Read More

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http://dx.doi.org/10.5604/01.3001.0013.5260DOI Listing
October 2019

A solitary supraglottic neurofibroma presenting with obstructive sleep apnea in an adolescent.

J Clin Sleep Med 2020 Apr;16(4):635-638

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, Stony Brook Medicine, Stony Brook, New York.

None: Obstructive sleep apnea (OSA) is commonly encountered in the pediatric population and has a large differential diagnosis. As clinicians, we must determine who needs to undergo flexible laryngoscopy to rule out potential obstructing lesions causing OSA. This report presents a 16-year-old female who presented with snoring, "asthma," dysphagia, and OSA. Read More

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http://dx.doi.org/10.5664/jcsm.8290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161452PMC

Soft tissue necrosis in patients treated with transoral robotic surgery and postoperative radiotherapy: preliminary results.

Tumori 2020 Jan 30:300891619900920. Epub 2020 Jan 30.

Department of Radiotherapy, IEO, European Institute of Oncology, IRCCS, Milan, Italy.

Objective: Postoperative radiotherapy (PORT) is indicated in almost two-thirds of patients treated with transoral robotic surgery (TORS) for head and neck tumors. The aim of this study was to quantify the toxicity profile of patients treated with PORT after TORS in oropharyngeal and supraglottic laryngeal cancer focusing on soft tissue necrosis (STN).

Methods: We retrospectively reviewed 28 patients. Read More

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http://dx.doi.org/10.1177/0300891619900920DOI Listing
January 2020

Assessment of HPV 16, HPV 18, p16 expression in advanced stage laryngeal cancer patients and prognostic significance.

Braz J Otorhinolaryngol 2020 May - Jun;86(3):351-357. Epub 2019 Dec 12.

Cukurova University School of Medicine, Department of Otorhinolaryngology Head & Neck Surgery, Adana, Turkey.

Introduction: Human papilloma virus is an etiological risk factor for a subset of head and neck squamous cell carcinomas. HPV has been proven to be a powerful prognostic biomarker for oropharyngeal cancer, but its role in the larynx has not been explored in depth. The developmental mechanisms of laryngeal carcinomas are quite complex and controlled by various factors. Read More

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http://dx.doi.org/10.1016/j.bjorl.2019.11.005DOI Listing

The Flex robotic system compared to transoral laser microsurgery for the resection of supraglottic carcinomas: first results and preliminary oncologic outcomes.

Eur Arch Otorhinolaryngol 2020 Mar 1;277(3):917-924. Epub 2020 Jan 1.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.

Purpose: Transoral robotic surgery (TORS) has the potential to improve some inherent disadvantages of transoral laser microsurgery (TLM). Here, we retrospectively assessed the application of the Medrobotics Flex system for the resection of supraglottic carcinomas compared to TLM.

Methods: 84 patients underwent surgery for supraglottic carcinomas with the Flex robotic system (n = 19, T-stage distribution in %: T1 42, T2 47, T3 11, T4 0) or TLM (n = 65, T-stage distribution in %: T1 40, T2 44, T3 14, T4 2). Read More

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http://dx.doi.org/10.1007/s00405-019-05767-0DOI Listing

Transoral Robot-Assisted Surgery in Supraglottic and Oropharyngeal Squamous Cell Carcinoma: Laser Versus Monopolar Electrocautery.

J Clin Med 2019 Dec 7;8(12). Epub 2019 Dec 7.

Unit of Pathology, Department of Molecular Medicine, University of Pavia, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy.

Background: Monopolar electrocautery (EC) is the surgical cutting and haemostatic tool most commonly used for transoral robotic surgery (TORS). The aim of this study was to retrospectively compare EC efficacy in the treatment of patients affected by T1 or T2 oropharyngeal and supraglottic squamous cell carcinomas with the more recently introduced laser fibres.

Methods: We considered all TORS patients admitted to our department from January 2010 to June 2019. Read More

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http://dx.doi.org/10.3390/jcm8122166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947577PMC
December 2019

Survival differences between definitive radiotherapy and surgery followed by adjuvant radiotherapy in supraglottic and hypopharyngeal carcinoma.

Chin Med J (Engl) 2019 Nov;132(22):2698-2704

Department of Radiation Oncology, Peking University First Hospital, Peking University, Beijing 100034, China.

Background: Organ preservation has long been a consideration in the treatment of supraglottic and hypopharyngeal carcinoma to improve the quality of life (QOL). Definitive radiotherapy (DRT) with or without systematic treatment, such as chemotherapy, is always the first choice to achieve improved QOL. This retrospective study focused on the survival differences between DRT and surgery followed by adjuvant radiotherapy (S + RT) in supraglottic and hypopharyngeal carcinoma. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940088PMC
November 2019

Supraglottic Mass Management in a Pediatric Patient with Proteus Syndrome.

Anesthesiology 2020 04;132(4):895

From the Children's Hospital Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1097/ALN.0000000000003058DOI Listing

Rational choice of neck dissection in clinically N0 patients with supraglottic cancer.

Head Neck 2020 Mar 14;42(3):365-373. Epub 2019 Nov 14.

Department of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.

Background: The mainstay treatment of the neck for clinically negative neck (cN0) supraglottic laryngeal carcinoma (SGLC) is neck dissection. However, the optimal extent remains controversial. This study's purpose is to determine whether ipsilateral level II-III neck dissection is appropriate for cN0SGLC patients. Read More

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http://dx.doi.org/10.1002/hed.26014DOI Listing

Functional Results after Larynx-Preserving Treatment of Laryngeal Cancer. Suggestions for follow-up.

Otolaryngol Pol 2019 Jun;73(5):31-36

Wydział Otolaryngologii i Chirurgii Głowy i Szyi, Uniwersytet Komeńskiego w Bratysławie, Słowacja.

ntroduction: Laryngeal cancer and its treatment are associated with both short- and long-term side effects, affecting laryngeal functions and having an impact on the quality of life. Material and methods: Retrospective analysis of the medical records of patients receiving surgical or non-surgical, larynx- -preserving treatment for laryngeal cancer. R esults: After termination of the treatment, the highest proportion of patients with bad voice quality was in the glottic carcinoma group (both in early and late phase), with swallowing dysfunction in the transglottic carcinoma group. Read More

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http://dx.doi.org/10.5604/01.3001.0013.2310DOI Listing

Does 5 + 5 Equal Better Radiation Treatment Plans in Head and Neck Cancers?

Adv Radiat Oncol 2019 Oct-Dec;4(4):683-688. Epub 2019 Jun 12.

Department of Radiation Oncology, London Health Sciences Centre, London, Ontario, Canada.

Purpose: Accurate contouring in head and neck cancer (HNC) is critical. International consensus guidelines recommend the 5 + 5 mm rule for expansions around the primary tumor, wherein high- and low-dose clinical target volumes (CTV-P1 and CTV-P2, respectively) are created using successive 5 mm expansions on the gross tumor volume. To our knowledge, the necessity of a low-dose CTV-P2 has never been assessed; therefore, we evaluated the dosimetric impact of adding a CTV-P2 expansion using the 5 + 5 mm rule compared with contouring with a high-dose CTV-P1 alone. Read More

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http://dx.doi.org/10.1016/j.adro.2019.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817533PMC
June 2019
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Minimally invasive surgery for laryngopharyngeal cancer: Multicenter feasibility study of a combination strategy involving transoral surgery and real-time indocyanine green fluorescence-navigated sentinel node navigation surgery.

Head Neck 2020 Feb 31;42(2):254-261. Epub 2019 Oct 31.

Department of Head and Neck Surgery and Otolaryngology, Asahi University Hospital, Gifu, Japan.

Background: Sentinel node navigation surgery using indocyanine green (ICG-SNNS) can be performed in the operation room. The combination of minimally invasive transoral surgery (TOS) with ICG-SNNS can provide functional preservation options for both primary lesions and lymph node (LN) metastasis. This multicenter feasibility study of this strategy was conducted in Japan. Read More

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http://dx.doi.org/10.1002/hed.25993DOI Listing
February 2020
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Second primary lung cancer following laryngeal cancer: retrospective study of incidence and multivariate analysis of risk factors in 209 patients.

J Laryngol Otol 2019 Oct 31:1-6. Epub 2019 Oct 31.

Department of Otolaryngology/Head and Neck Surgery, Royal Victoria Hospital, Belfast, Northern Ireland, UK.

Objective: To analyse the incidence of second primary lung cancer following treatment for laryngeal cancer and to identify risk factors for its development.

Method: Retrospective case series.

Results: The five-year actuarial incidence of second primary lung cancer was 8 per cent (1. Read More

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http://dx.doi.org/10.1017/S0022215119002147DOI Listing
October 2019

Identifying organs at risk for radiation-induced late dysphagia in head and neck cancer patients.

Clin Transl Radiat Oncol 2019 Nov 30;19:87-95. Epub 2019 Aug 30.

Department of Radiation Physics, Institute of Clinical Sciences, the Sahlgrenska Academy Gothenburg University, 413 45 Gothenburg, Sweden.

Background And Purpose: Dysphagia is a common, severe and dose-limiting toxicity after oncological treatment of head and neck cancer (HNC). This study aims to investigate relationships between radiation doses to structures involved in normal swallowing and patient-reported as well as clinically measured swallowing function in HNC patients after curative (chemo-) radiation therapy (RT) with focus on late effects.

Materials And Methods: Patients (n = 90) with HNC curatively treated with RT ± chemotherapy in 2007-2015 were assessed for dysphagia post-treatment by telephone interview and videofluoroscopy (VFS). Read More

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http://dx.doi.org/10.1016/j.ctro.2019.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804434PMC
November 2019
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Predictors of Occult Lymph Node Metastasis and Prognosis in Patients with cN0 T1-T2 Supraglottic Laryngeal Carcinoma: A Retrospective Study.

ORL J Otorhinolaryngol Relat Spec 2019;81(5-6):317-326. Epub 2019 Oct 22.

Department of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,

Background: This work aimed to explore the predictors of lymph node metastasis (LNM) and analyze the prognosis of patients with clinically node-negative (cN0) T1-T2 supraglottic laryngeal carcinoma (SGLC).

Methods: Data for 130 patients with cN0 T1-T2 SGLC who initially underwent surgery were retrospectively reviewed. Occult LNM incidence, relevant factors, and prognosis were analyzed. Read More

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http://dx.doi.org/10.1159/000503007DOI Listing
October 2019
2 Reads

Large Laryngeal Lipoma with Extra Laryngeal Component Mimics Mixed Form Laryngocele: A Case Report.

Adv J Emerg Med 2019 28;3(4):e45. Epub 2019 Jul 28.

Department of General Surgery, Hamadan University of Medical Sciences, Besat Hospital, Hamadan, Iran.

Introduction: Lipomas are the most common benign neoplasms, occurring in any part of the body where fat is present. Their occurrence in the head and neck is not common. Here, we report a large laryngeal lipoma with extra laryngeal component, mimicking mixed form of laryngocele. Read More

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http://dx.doi.org/10.22114/ajem.v0i0.196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789068PMC
July 2019
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Predictors for failure of supraglottic superimposed high-frequency jet ventilation during upper airway surgery in adult patients; a retrospective cohort study of 224 cases.

Clin Otolaryngol 2020 Mar 12;45(2):253-258. Epub 2019 Dec 12.

Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1111/coa.13465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027582PMC
March 2020
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Supraglottic p16+ squamous cell carcinoma during pregnancy: a case report and review of the literature.

J Otolaryngol Head Neck Surg 2019 Oct 15;48(1):47. Epub 2019 Oct 15.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, ON, Canada.

Background: Head and neck cancer during pregnancy is uncommon. Specifically, laryngeal cancer in pregnancy has only been previously reported 10 times. HPV p16+ supraglottic cancer during pregnancy has never been described in the literature prior to this case report. Read More

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http://dx.doi.org/10.1186/s40463-019-0378-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794888PMC
October 2019
2 Reads

Supraglottic devices for airway management in awake craniotomy.

Medicine (Baltimore) 2019 Oct;98(40):e17473

Department of Anesthesiology and Intensive Care Medicine.

Awake craniotomy is a unique technique utilized for mapping neuro and motor function during neurosurgical procedures close to eloquent brain tissue. Since active communication is required only during surgical manipulation of eloquent brain tissue and the patient is "sedated" during other parts of the procedure, different methods for anesthesia management have been explored. Furthermore, airway management ranges from spontaneous breathing to oro or nasotracheal intubation. Read More

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http://dx.doi.org/10.1097/MD.0000000000017473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783250PMC
October 2019
3 Reads

Transoral videolaryngoscopic surgery for laryngeal and hypopharyngeal cancer - Technical updates and long-term results.

Auris Nasus Larynx 2020 Apr 27;47(2):282-290. Epub 2019 Sep 27.

Department of Otolaryngology, Head and Neck Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Objective: Transoral videolaryngoscopic surgery (TOVS) was developed as a non-robotic procedure for en bloc laryngo-hypopharyngeal cancer resection. Straight devices had been used for this procedure, however, some cases had difficulty to reach the lesions especially in hypopharyngeal area. To overcome this problem, technical updates to facilitate transoral manipulation were developed and long term oncological and functional results were analyzed. Read More

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http://dx.doi.org/10.1016/j.anl.2019.09.003DOI Listing
April 2020
9 Reads

Primary Ewing sarcoma of the larynx with distant metastasis: a case report and review of the literature.

Curr Oncol 2019 08 1;26(4):e574-e577. Epub 2019 Aug 1.

Department of Otolaryngology Head and Neck Surgery, American University of Beirut Medical Center, Beirut, Lebanon.

Extraosseous Ewing sarcoma is a rare, poorly differentiated round-cell tumour that is part of the Ewing sarcoma family of tumours. Here, we present an extremely rare case of primary extraosseous Ewing sarcoma arising in the larynx, with distant metastases. A 53-year-old man with a history of Hodgkin lymphoma treated 4 years earlier with 8 cycles of chemotherapy presented to our medical centre with a 2-week history of hoarseness. Read More

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http://dx.doi.org/10.3747/co.26.5001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726258PMC
August 2019
3 Reads

Hematologic malignancies of the larynx: A single institution review.

Am J Otolaryngol 2019 Nov - Dec;40(6):102285. Epub 2019 Sep 4.

Division of Laryngology, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, United States of America.

Background: Primary hematologic malignancies of the larynx are rare diagnoses, accounting for less than 1% of all laryngeal tumors. They most commonly present as submucosal masses of the supraglottis, with symptoms including hoarseness, dysphagia, dyspnea and rarely cervical lymphadenopathy.

Purpose: METHODS: Retrospective case series of patients in a tertiary academic laryngeal practice with hematologic malignancy of the larynx presenting over a 10 year period; charts were reviewed for diagnosis, symptoms, treatment, and outcomes. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.102285DOI Listing
April 2020
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Defect repair with fibrin glue/polyglycolic acid after endoscopic laryngopharyngeal cancer resection.

Laryngoscope 2020 Jul 28;130(7):1740-1745. Epub 2019 Aug 28.

Department of Otolaryngology-Head and Neck Surgery, Japanese Red Cross Osaka Hospital, Osaka, Japan.

Objectives/hypothesis: In 2013, we introduced a modified technique for mucosal/muscle layer defect coverage with fibrin glue and polyglycolic acid (PGA) sheets (mMCFP technique) in patients undergoing endoscopic transoral surgeries for laryngopharyngeal cancers. This technique allows easy and convenient coverage of the wound surface, even when it involves the laryngopharyngeal lumen. To our knowledge, use of the MCFP technique for coverage of postoperative mucosal and/or muscle layer defects involving the laryngopharyngeal lumen has not been reported. Read More

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http://dx.doi.org/10.1002/lary.28265DOI Listing
July 2020
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PTEN Is Associated With Worse Local Control in Early Stage Supraglottic Laryngeal Cancer Treated With Radiotherapy.

Laryngoscope Investig Otolaryngol 2019 Aug 12;4(4):399-404. Epub 2019 Jun 12.

Department of Otorhinolaryngology/Head and Neck Surgery University Medical Center Groningen, University of Groningen Groningen The Netherlands.

Objectives: The aim of this study was to establish the prognostic value of the epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression on local control in patients with early stage supraglottic laryngeal squamous cell carcinoma (LSCC) treated with radiotherapy only.

Study Design: Retrospective cohort study.

Methods: Immunohistochemical staining for EGFR and PTEN was performed on pretreatment biopsies of a selected well-defined homogeneous group of 52 patients with T1-T2 supraglottic LSCC treated with radiotherapy between 1990 and 2008. Read More

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http://dx.doi.org/10.1002/lio2.272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703112PMC
August 2019
4 Reads