2,086 results match your criteria Supraglottic Cancer


Value of patient-reported symptoms in the follow up of patients potentially cured of laryngeal carcinoma.

J Laryngol Otol 2019 Apr 22:1-7. Epub 2019 Apr 22.

Department of Oto-Rhino-Laryngology,Head and Neck Surgery,Division of Surgery and Clinical Neuroscience,Oslo University Hospital,Norway.

Objective: To evaluate the significance of patients' ability to recognise symptoms that signify recurrence.

Methods: A retrospective analysis was conducted in Norway of demographic, clinical and follow-up data for patients with laryngeal carcinoma considered free of disease following treatment. The study included clinical data from 732 patients with glottic tumours and 249 patients with supraglottic tumours who were considered cured of disease. Read More

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http://dx.doi.org/10.1017/S0022215119000677DOI Listing

Meta-analytic comparison of robotic and transoral laser surgical procedures in supraglottic carcinoma.

J Laryngol Otol 2019 Apr 12:1-9. Epub 2019 Apr 12.

Department of Medical Biochemistry,Acibadem Mehmet Aydinlar University,Ankara,Turkey.

Objective: To assess published reports of oncological surgical success rates in patients who underwent transoral laser supraglottic surgery and robotic surgery for supraglottic cancer.

Methods: A systematic review of the literature was conducted and a meta-analysis of published data was performed. PubMed, Sage, Medline and Cochrane data sources were investigated. Read More

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http://dx.doi.org/10.1017/S0022215119000707DOI Listing

Radiation Therapy Impact on Lymph Node Yield in Patients With Laryngeal Squamous Cell Carcinoma.

Ear Nose Throat J 2019 Apr 8:145561319839790. Epub 2019 Apr 8.

1 Department of Otolaryngology-Head and Neck Surgery, Augusta University, Augusta, GA, USA.

Background: A lymph node yield (LNY) over 20 is considered a quality metric for lateral neck dissection to ensure an oncologic representative sample. Anecdotally, however, LNY in patients undergoing neck dissection after radiation therapy (RT) is lower due to atrophy and fibrosis.

Objective: To determine whether preoperative RT decreases LNY in patients with laryngeal cancers undergoing surgery. Read More

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http://dx.doi.org/10.1177/0145561319839790DOI Listing
April 2019
7 Reads

Oncological outcome following TORS in HPV negative supraglottic carcinoma.

Indian J Cancer 2019 Jan-Mar;56(1):9-14

Department of Surgical Oncology, BLK Super Specialty Hospital, Pusa Road, Delhi, India.

Objective: The aim of this study was to determine the oncological and functional outcomes following transoral robotic surgery (TORS) in human papilloma virus negative supraglottic cancers.

Study Design: A prospective observational study at a tertiary cancer care center, New Delhi, India.

Materials And Methods: From February, 2013 to December, 2015, 45 patients with supraglottic lesions underwent TORS using the da Vinci® surgical system. Read More

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http://dx.doi.org/10.4103/ijc.IJC_172_18DOI Listing
April 2019
6 Reads

Hypopharyngeal Skin Cancer Following Total Laryngectomy and Pectoralis Flap Reconstruction: Case Report and Literature Review.

Head Neck Pathol 2019 Mar 19. Epub 2019 Mar 19.

Department of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.

Although early complications of microvascular free flaps and regional pedicled flaps of the head and neck are well described in the literature, there is relatively limited knowledge regarding their long-term complications. We describe the case of a 62-year-old gentleman who underwent primary resection and adjuvant radiation therapy for supraglottic squamous cell carcinoma who subsequently underwent salvage total laryngectomy with pectoralis major muscle flap reconstruction. During a later esophageal dilation for complaints of dysphagia, a new exophytic lesion of the hypopharynx was biopsied on endoscopy. Read More

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http://dx.doi.org/10.1007/s12105-019-01029-xDOI Listing
March 2019
2 Reads

Dose-volume relationship for laryngeal substructures and aspiration in patients with locally advanced head-and-neck cancer.

Radiat Oncol 2019 Mar 18;14(1):49. Epub 2019 Mar 18.

Department of Radiation Oncology, Northwestern University, Chicago, IL, USA.

Background: Literature has shown a significant relationship between radiation dose to the larynx and swallowing disorders. We prospectively studied the dose-volume relationship for larynx substructures and aspiration.

Methods: Forty nine patients with stage III/IV head-and-neck (H&N) squamous cell carcinoma were prospectively enrolled in this IRB-approved, federally funded study. Read More

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http://dx.doi.org/10.1186/s13014-019-1247-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423881PMC
March 2019
1 Read

Early Closure of a Phase 1 Clinical Trial for SABR in Early-Stage Glottic Cancer.

Int J Radiat Oncol Biol Phys 2019 Mar 14. Epub 2019 Mar 14.

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institution, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea. Electronic address:

Purpose: The early results of a phase 1 study of stereotactic ablative radiation therapy for early-stage glottis cancer were previously reported. However, additional late adverse events occurred in the second arm during the follow-up period. In this study, the dose-limiting toxicities and premature closure of the clinical trial are reported. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.03.011DOI Listing
March 2019
2 Reads
4.258 Impact Factor

Arytenoid Fixation in Laryngeal Cancer: Radiological Pictures and Clinical Correlations with Respect to Conservative Treatments.

Cancers (Basel) 2019 Mar 13;11(3). Epub 2019 Mar 13.

Head and Neck Oncology Service, Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo (TO), Italy.

The aim of this retrospective study was to identify different radiological features in intermediate⁻advanced laryngeal cancer (LC) associated with arytenoid fixation, in order to differentiate cases still safely amenable to conservative treatment by partial laryngectomy or chemoradiotherapy. : 29 consecutive patients who underwent open partial horizontal laryngectomies (OPHLs), induction chemotherapy followed by radiotherapy in the case of >50% response (IC + RT) or total laryngectomy were classified as: pattern I (supraglottic LC fixing the arytenoid due to weight effect), pattern II (glottic LC involving the posterior paraglottic space and spreading toward the crico-arytenoid joint and infraglottic extension <10 mm), pattern III (glottic-infraglottic LC involving the crico-arytenoid joint and infraglottic extension >10 mm) and pattern IV (transglottic and infraglottic LC with massive crico-arytenoid unit involvement, reaching the hypopharyngeal submucosa). All glottic cancers treated with surgery were studied by a cross sectional approach. Read More

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http://dx.doi.org/10.3390/cancers11030360DOI Listing
March 2019
1 Read

The role of elective neck dissection for cT4aN0 glottic squamous cell carcinoma.

Jpn J Clin Oncol 2019 Mar 4. Epub 2019 Mar 4.

Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Objective: The indication for elective neck dissection for patients with clinically T4aN0 (cT4aN0) glottic cancer is not established. The objective of this study was to evaluate the role of elective neck dissection for patients with cT4aN0 glottic cancer.

Methods: We assessed patients with cT4aN0 laryngeal squamous cell carcinoma who underwent total laryngectomy between 1998 and 2014 and conducted a retrospective analysis. Read More

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http://dx.doi.org/10.1093/jjco/hyz022DOI Listing
March 2019
5 Reads

Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014.

Acta Oncol 2019 Mar 1:1-6. Epub 2019 Mar 1.

a Department of Otorhinolaryngology, Head and Neck Surgery and Audiology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.

Background: The purpose of this registry study was to evaluate trends in incidence and survival of laryngeal cancer in the Danish population from 1980 to 2014.

Methods: This study includes all patients with laryngeal cancer registered in the Danish Cancer Registry (DCR) in the period 1980-2014. The age-adjusted incidence rate (AAIR) per 100,000 and average annual percent change (AAPC) were calculated. Read More

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https://www.tandfonline.com/doi/full/10.1080/0284186X.2019.1
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http://dx.doi.org/10.1080/0284186X.2019.1572923DOI Listing
March 2019
4 Reads

Clinical Utility of Pretreatment and 3-Month F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Standardized Uptake Value in Predicting and Assessing Recurrence in T3-T4 Laryngeal Carcinoma Treated With Definitive Radiation.

Ann Otol Rhinol Laryngol 2019 Feb 27:3489419834312. Epub 2019 Feb 27.

1 Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Objectives:: The aim of this study was to investigate the utility of pretreatment and 3-month F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) standardized uptake value (SUV) in predicting and assessing recurrence in T3-T4 laryngeal carcinoma treated with definitive radiation therapy (RT).

Methods:: Patients with newly diagnosed T3-T4 laryngeal squamous cell carcinoma treated with definitive RT from 2004 to 2014 were reviewed. Patients who underwent pretreatment or 3-month PET/CT 2 to 4 months after treatment were included. Read More

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http://dx.doi.org/10.1177/0003489419834312DOI Listing
February 2019

Clinical outcomes of end-flexible-rigidscopic transoral surgery (E-TOS) in patients with T1-selected T3 pharyngeal and supraglottic cancers.

Acta Otolaryngol 2019 Feb 21;139(2):187-194. Epub 2019 Feb 21.

a Otolaryngology-Head & Neck Surgery , Osaka Red Cross Hospital , Osaka , Japan.

Background: Endoscopic laryngo-pharyngeal surgery (ELPS), which is a transoral minimally invasive surgery using a gastrointestinal endoscope and a curved laryngopharyngeal retractor, is effective to treat primary lesions of superficial laryngopharyngeal cancers. To extend concepts of ELPS to invasive laryngopharyngeal cancers, we developed end-flexible-rigidscopic transoral surgery (E-TOS) from ELPS by changing a gastrointestinal endoscope to a flexible-tip rigid endoscope.

Aims/objectives: To retrospectively evaluate oncological outcomes and laryngopharyngeal functional preservation of E-TOS in patients with T1-selected T3 laryngopharyngeal cancers. Read More

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http://dx.doi.org/10.1080/00016489.2018.1532106DOI Listing
February 2019
2 Reads

Transoral supraglottic laryngectomy using a next-generation single-port robotic surgical system.

Head Neck 2019 Feb 18. Epub 2019 Feb 18.

Department of Otolaryngology - Head & Neck Surgery, "Regina Elena" National Cancer Institute, Rome, Italy.

Background: To investigate the feasibility of transoral robotic surgery (TORS) supraglottic laryngectomy (SGL) using a next-generation flexible surgical robot.

Methods: Preclinical human cadaver anatomic study of TORS SGL via en bloc resection.

Results: A single-port robotic surgical system (da Vinci Sp, Intuitive Surgical, Inc. Read More

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http://dx.doi.org/10.1002/hed.25676DOI Listing
February 2019

Oncological outcomes of surgical treatment for T3 supraglottic laryngeal squamous cell carcinoma patients.

Acta Otolaryngol 2018 Nov 8;138(11):1028-1034. Epub 2019 Feb 8.

a Department of Otorhinolaryngology , Fudan University, Eye Ear Nose and Throat Hospital , Shanghai , China.

Background: T3 supraglottic laryngeal carcinoma (LC) is a common advanced laryngeal cancer.

Objective: This study was conducted to assess the clinical results of pathological T3 (pT3) supraglottic LC patients who were amenable to laryngectomy treated with primary surgery and postoperative therapy.

Methods: Retrospective review of 202 pT3 cases of supraglottic laryngeal squamous cell carcinoma. Read More

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http://dx.doi.org/10.1080/00016489.2018.1490031DOI Listing
November 2018
4 Reads

Dysphagia optimized radiotherapy to reduce swallowing dysfunction severity in patients undergoing treatment for head and neck cancer: A systematized scoping review.

Head Neck 2019 Feb 5. Epub 2019 Feb 5.

Division of Speech Pathology, School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, Queensland, Australia.

This study involved a systematized scoping review to coalesce current evidence on dysphagia outcomes achieved through active sparing of the swallowing structures in patients receiving radiotherapy for head and neck cancer. Eligible publications between 2007 and 2017 were reviewed and synthesized regarding participant demographics, treatment regimens, swallowing structures chosen for optimization, dosimetric constraints, and dysphagia measures. Nine prospective cohort studies were included. Read More

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http://dx.doi.org/10.1002/hed.25688DOI Listing
February 2019
2 Reads

The prognostic value of tumor depth for cervical lymph node metastasis in hypopharyngeal and supraglottic carcinomas.

Head Neck 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: To analyze the prognostic value of the clinicopathological parameters of primary lesions for predicting cervical lymph node metastasis in patients with hypopharyngeal and/or supraglottic carcinoma.

Methods: We enrolled 127 patients with squamous cell carcinomas originating in the hypopharyngeal and/or supraglottic regions.

Results: Multivariate analysis identified the tumor depth as an independent predictive factor for lymph node metastasis (odds ratio, 4. Read More

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http://dx.doi.org/10.1002/hed.25667DOI Listing
January 2019
2 Reads

Transoral robotic excision of laryngocele: Surgical considerations.

Head Neck 2019 Apr 16;41(4):1140-1143. Epub 2019 Jan 16.

Department of Otolaryngology-Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: Transoral robotic surgery (TORS) has emerged as a novel, safe, and feasible procedure for the resection of malignant supraglottic laryngeal cancers. The purpose of this study was to demonstrate the surgical technique with extension of the use of TORS to excise a laryngeal cyst.

Results: Laryngeal cyst resection, along with its tract, was accomplished with preservation of both false and true vocal cords. Read More

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http://doi.wiley.com/10.1002/hed.25612
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http://dx.doi.org/10.1002/hed.25612DOI Listing
April 2019
10 Reads

Dual-energy computed tomography for prediction of loco-regional recurrence after radiotherapy in larynx and hypopharynx squamous cell carcinoma.

Eur J Radiol 2019 Jan 5;110:1-6. Epub 2018 Nov 5.

Radiation Oncology Department, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.

Purpose: To investigate the role of quantitative pre-treatment dual-energy computed tomography (DECT) for prediction of loco-regional recurrence (LRR) in patients with larynx/hypopharynx squamous cell cancer (L/H SCC).

Methods: Patients with L/H SCC treated with curative intent loco-regional radiotherapy and that underwent treatment planning with contrast-enhanced DECT of the neck were included. Primary and nodal gross tumor volumes (GTVp and GTVn) were contoured and transferred into a Matlab® workspace. Read More

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http://dx.doi.org/10.1016/j.ejrad.2018.11.005DOI Listing
January 2019
2 Reads

Functional outcomes in early (T1/T2) supraglottic cancer: a systematic review.

J Otolaryngol Head Neck Surg 2018 Dec 18;47(1):76. Epub 2018 Dec 18.

Department of Otolaryngology, Head & Neck Surgery, Schulich Medicine & Dentistry, Western University, London Health Sciences Centre, Victoria Hospital, London, Ontario, Canada.

Objectives: Organ preserving surgery (OPS) and radiotherapy (RT) are both accepted treatment options for early stage supraglottic cancer (SGC). Radiation has supplanted surgery in most cases, because of the perception that surgery results in poorer functional outcomes. However, evidence suggests that OPS with a neck dissection may be associated with improved survival. Read More

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http://dx.doi.org/10.1186/s40463-018-0321-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299571PMC
December 2018
4 Reads

Comparison of Swallowing Act Videofluoroscopy after Open and Laser Partial Supraglottic Laryngectomy.

Iran J Otorhinolaryngol 2018 Nov;30(101):315-319

Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Hospital Center Zagreb, Zagreb, Croatia.

Introduction: The aim of this study was to compare the functional outcomes of swallowing act detected by videofluoroscopy of two different techniques in the treatment of laryngeal carcinoma.

Materials And Methods: This study was conducted on 41 patients undergoing two supraglottic laryngectomy techniques. The research population was assigned into two groups of open and laser supraglottic laryngectomy, including 21 and 20 patients, respectively. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291820PMC
November 2018

Supraglottic Squamous Cell Carcinoma: A Population-Based Study of 22,675 Cases.

Laryngoscope 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey, Newark, New Jersey, U.S.A.

Objectives/hypothesis: The authors used the Surveillance, Epidemiology, and End Results (SEER) database to analyze epidemiological features of patients presenting with supraglottic squamous cell carcinoma (SCCa) and to evaluate treatment trends and outcomes.

Methods: The SEER database was queried for patients with supraglottic SCCa from 1973 to 2013. Information on demographics; tumor size; histologic grade; American Joint Committee on Cancer (AJCC) stage; SEER local, regional, distant stage; and treatment modality were analyzed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lary.27592
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http://dx.doi.org/10.1002/lary.27592DOI Listing
December 2018
4 Reads

Characterizing post-extubation negative pressure pulmonary edema in the operating room-a retrospective matched case-control study.

Perioper Med (Lond) 2018 6;7:28. Epub 2018 Dec 6.

1Department of Anesthesiology, E-Da Hospital/E-Da Cancer Hospital, I-Shou University, No 1, Yida Road. Yanchao Dist., Kaohsiung city, 824 Taiwan.

Background: Post-extubation negative pressure pulmonary edema (NPPE) is an uncommon but important anesthesia-related emergency presenting with acute respiratory distress and hypoxemia after removal of airway devices. This study investigated the incidence and associated risk factors for post-extubation NPPE during emergence.

Methods: This retrospective, matched case-control study was conducted by reviewing the post-anesthesia records in Tzu Chi General Hospital, Taiwan. Read More

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http://dx.doi.org/10.1186/s13741-018-0107-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282297PMC
December 2018
2 Reads

Laryngeal synovial sarcoma: Report of 2 cases.

J Egypt Natl Canc Inst 2018 Dec 24;30(4):173-176. Epub 2018 Nov 24.

ENT Department, Farhat Hached University Hospital, Sousse, Tunisia.

Synovial sarcoma is a malignant mesenchymal tumor. It most commonly occurs in the lower extremities of young adults. The head and neck are rare sites, accounting for less than 10%. Read More

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http://dx.doi.org/10.1016/j.jnci.2018.10.002DOI Listing
December 2018
21 Reads

Metastasis of adenoid cystic carcinoma from a submandibular gland to the larynx.

Auris Nasus Larynx 2018 Nov 22. Epub 2018 Nov 22.

Department of Otorhinolaryngology, Head & Neck Surgery, National Sencai Medical Center, Japan.

The present article discusses the first reported case of adenoid cystic carcinoma (ACC) metastasis from a submandibular gland to the larynx. Both treatments of distant metastasis of ACC and secondary laryngeal tumor are challenging. Despite its slow progression, ACC is associated with high rates of local recurrence, distant metastasis, and poor prognosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03858146183064
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http://dx.doi.org/10.1016/j.anl.2018.11.001DOI Listing
November 2018
14 Reads

[The morphplogical and its influencing factors research after supracricoid partial laryngectory with cricohyoidoepiglottopexy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(20):1584-1587

Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.

The aim of this study for observing laryngeal morphology, and motion characteristics after supracricoid partial laryngectomy with cricohyoidoepiglottopexy(SCPL-CHEP),exploring the relevant factors affecting the morphology of new laryngeal. Choose 46 cases of patients with laryngeal cancer for SCPL-CHEP as the object of study, dynamic laryngoscope were performed in all the patients, to observe the movement of laryngeal pronunciation (neoglottis closure , supraglottic situation) . Combined with the patient's clinical data, the relevant factors that may affect the pronunciation and movement characteristics of the new throat were analyzed. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2018.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.20.012DOI Listing
October 2018
11 Reads

Radiation Therapy for Tracheobronchial Metastases from Head and Neck Squamous Cell Carcinoma.

Cureus 2018 Aug 15;10(8):e3151. Epub 2018 Aug 15.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, USA.

Tracheobronchial metastases from head and neck squamous cell carcinoma (HNSCC) represent a rare occurrence, with few reported cases in the literature. Here, we present two patients with HNSCC who developed tracheobronchial metastases at different time points in their disease course. Patient 1 presented with a localized tonsillar primary, underwent tonsillectomy and post-operative radiation therapy to the tumor bed and bilateral neck, and experienced multiple subsequent metastases in different locations throughout the tracheobronchial tree. Read More

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https://www.cureus.com/articles/13993-radiation-therapy-for-
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http://dx.doi.org/10.7759/cureus.3151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191010PMC
August 2018
22 Reads

Radiation-Associated Chronic Dysphagia Assessment by Flexible Endoscopic Evaluation of Swallowing (FEES) in Head and Neck Cancer Patients: Swallowing-Related Structures and Radiation Dose-Volume Effect.

Ann Otol Rhinol Laryngol 2019 Feb 20;128(2):73-84. Epub 2018 Oct 20.

1 Faculty of Medicine, Department of Radiation Oncology, Ege University, Ankara Street, Izmir, Turkey.

Purpose: We aimed to restore dose-volume parameters of swallowing-related structures (SRSs) by evaluating long-term swallowing dysfunctions after radiotherapy (RT) in head and neck cancer patients (HNCPs).

Materials And Methods: Head and neck cancer patients whose pharyngeal region was involved in RT portal and treated with definitive RT/chemoradiotherapy (CRT) were included in the analyses. Patients underwent objective swallowing assessment by flexible endoscopic evaluation of swallowing (FEES). Read More

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http://dx.doi.org/10.1177/0003489418804260DOI Listing
February 2019
23 Reads

[Clinical analysis of malignant salivary gland tumors of the larynx].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;53(9):684-687

Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai 200031, China.

To evaluate the clinical features, treatments and prognoses of malignant salivary gland tumors of the larynx. A total of 14 patients with malignant salivary gland tumors of the larynx diagnosed and treated in our hospital between 2003 and 2014 were analyzed retrospectively, and were compared with 62 patients from the Surveillance, Epidemiology, and End (SEER) database of American for survival rates. Results Among 14 patients from our hospital, 9 males and 5 females, with a median of 66. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2018.09.009DOI Listing
September 2018
16 Reads

CO Transoral Microsurgery for Supraglottic Squamous Cell Carcinoma.

Front Oncol 2018 4;8:321. Epub 2018 Sep 4.

Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Cagliari, Italy.

The present study analyzed the results of the endoscopic approach to T1, T2 and selected T3 supraglottic carcinoma with the aim of reviewing functional and oncologic outcomes after different types of endoscopic supraglottic laryngectomies. This is a retrospective clinical study of 42 consecutive patients (mean age of 61.8 years, 33 males, 9 females) treated by the senior author for supraglottic squamous cell carcinoma with a transoral CO laser approach and reviewed from November 2010 to September 2017. Read More

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http://dx.doi.org/10.3389/fonc.2018.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131582PMC
September 2018
11 Reads

[Significance of HPV and cell cycle related proteins in basaloid squamous cell carcinoma of the larynx].

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):682-686

Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

To study the significance of HPV and cell cycle related proteins in basaloid squamous cell carcinoma (BSCC) of the larynx. Twenty-nine cases of laryngeal BSCC from Beijing Tongren Hospital from January 2005 to December 2011 were reviewed. HPV typing by polymerase chain reaction-reverse dot blot (PCR-RDB) and p53, Ki-67, p16, p21 and cyclin D1 expression by immunohistochemistry were performed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.09.006DOI Listing
September 2018
1 Read

Airway management in microgravity: A systematic review.

Acta Anaesthesiol Scand 2019 Jan 10;63(1):2-7. Epub 2018 Sep 10.

Department of Anesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany.

Introduction: In the near future, space programs will shift their focus toward long-duration interplanetary missions, in particular to the Moon and Mars. These exploration missions will be associated with an increased risk of acute medical problems, which will need to be handled by an autonomous crew operating in extreme isolation. An important skill in emergencies is represented by airway management. Read More

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http://dx.doi.org/10.1111/aas.13251DOI Listing
January 2019
2 Reads

The correlation of prognostic biomarkers (Ki-67, Bcl-2, HIF-1α, cyclin D1) with metabolic tumor volume measured by F-FDG PET/CT inlaryngeal cancer.

J Cancer Res Ther 2018 Jul-Sep;14(5):994-998

Department of Nuclear Medicine, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.

Objectives: To investigate the correlation between tumor stage, Ki-67, Bcl-2, hypoxia inducible factor-1α (HIF-1α), cyclin D1 and metabolic tumor volume (MTV), total lesion glycolysis (TLG), maximum standardized uptake value (SUV) measured by F fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in patients diagnosed with laryngeal cancer.

Patients And Methods: In this study, included 25 consecutive laryngeal cancer patients (2 women, 23 men) diagnosed and treated in the Otorhinolaryngology Department of our tertiary care center. All cases underwent F FDG PET/CT and SUV, mean standardized uptake value, MTV, and TLG values were calculated. Read More

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http://dx.doi.org/10.4103/0973-1482.179162DOI Listing
November 2018
1 Read

Synchronous Laryngeal Squamous Cell Carcinoma and Intrahepatic Cholangiocarcinoma Present in an Obese Male with Poor Prognosis.

Anticancer Res 2018 Sep;38(9):5547-5550

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.

Concurrent laryngeal squamous cell carcinoma and intrahepatic cholangiocarcinoma is rare and no prior report has been found through a PubMed search. Here we report such a case of a 51-year old obese male presenting with hoarseness and trouble swallowing for 2 to 3 months. Imaging findings of computer tomography (CT) and magnetic resonance imaging (MRI) with and without contrast were suspicious for a T3N2 supraglottic laryngeal cancer. Read More

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http://dx.doi.org/10.21873/anticanres.12890DOI Listing
September 2018
19 Reads

[HYPERBARIC OXYGEN TREATMENT FOR POST RADIATION NECROSIS].

Harefuah 2018 Aug;157(8):486-489

Department of Internal Medicine, Yoseftal Hospital, Eilat.

Introduction: Radiation therapy is an acceptable treatment for several types of malignancies. Despite advances in technology, the adverse effects of radiation therapy are still common. Tissue radio necrosis/post radiation necrosis is a frequent adverse event occurring in 5-15% of the patients undergoing radiation therapy. Read More

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August 2018
3 Reads

Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest on Functional Outcome: The AIRWAYS-2 Randomized Clinical Trial.

JAMA 2018 08;320(8):779-791

Clinical Trials and Evaluation Unit, Bristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, England.

Importance: The optimal approach to airway management during out-of-hospital cardiac arrest is unknown.

Objective: To determine whether a supraglottic airway device (SGA) is superior to tracheal intubation (TI) as the initial advanced airway management strategy in adults with nontraumatic out-of-hospital cardiac arrest.

Design, Setting, And Participants: Multicenter, cluster randomized clinical trial of paramedics from 4 ambulance services in England responding to emergencies for approximately 21 million people. Read More

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http://dx.doi.org/10.1001/jama.2018.11597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142999PMC
August 2018
71 Reads

The acceptance and adoption of transoral robotic surgery in Australia and New Zealand.

J Robot Surg 2019 Apr 20;13(2):301-307. Epub 2018 Aug 20.

Department of Otolaryngology, Head and Neck surgery, The Royal Adelaide Hospital, Port Road, Adelaide, SA, 5000, Australia.

Transoral robotic surgery (TORS) provides improved access to head and neck subsites resulting in well-validated functional and oncological outcomes, but access to and cost of robotic platforms can limit their use. Evidence suggests TORS is increasingly being adopted globally, but there is a paucity of data on the adoption and diffusion of TORS in Australia and New Zealand. A cross-sectional analysis was performed. Read More

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http://dx.doi.org/10.1007/s11701-018-0856-8DOI Listing
April 2019
3 Reads

SPECT/CT-guided elective nodal irradiation for head and neck cancer: Estimation of clinical benefits using NTCP models.

Radiother Oncol 2019 Jan 4;130:18-24. Epub 2018 Aug 4.

Department of Radiation Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek, Amsterdam, The Netherlands. Electronic address:

Background And Purpose: The great majority of patients with lateralized head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy routinely undergo bilateral elective nodal irradiation (ENI), even though the incidence of contralateral regional failure after unilateral ENI is low. Excluding the contralateral neck from elective irradiation could reduce radiation-related toxicity and improve quality-of-life. The current study investigated the dosimetric benefits of a novel approach using lymph drainage mapping by SPECT/CT to select patients for unilateral ENI. Read More

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http://dx.doi.org/10.1016/j.radonc.2018.07.023DOI Listing
January 2019
2 Reads

Comparison of functional and oncological treatment outcomes after transoral robotic surgery and open surgery for supraglottic laryngeal cancer.

J Laryngol Otol 2018 09 8;132(9):832-836. Epub 2018 Aug 8.

Otolaryngology Department,University of Health Sciences,Ümraniye Education and Research Hospital,Istanbul,Turkey.

Objective: To compare functional and oncological treatment outcomes among patients with supraglottic laryngeal cancers who underwent transoral robotic supraglottic laryngectomy and open supraglottic laryngectomy.

Methods: A retrospective chart review was conducted of 17 patients treated by transoral robotic supraglottic laryngectomy and 20 patients treated by open supraglottic laryngectomy.

Results: No tracheostomy or prolonged intubation was needed in the transoral robotic surgery group. Read More

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http://dx.doi.org/10.1017/S0022215118001305DOI Listing
September 2018
3 Reads

Post-treatment sequelae and management of primary laryngeal NK/T-cell lymphoma: A case report.

Am J Otolaryngol 2018 Nov - Dec;39(6):781-784. Epub 2018 Jul 25.

Cleveland Clinic, 9500 Euclid Ave, A-71, Cleveland, OH 44195, United States of America. Electronic address:

Outcome Objectives: METHODS: Case Report, April 2016.

Results: A 27-year-old female presented with a three-week history of flu-like symptoms including sore throat, myalgia and insidious nasal congestion. Her hospital course was complicated by pancytopenia, extensive GI bleed of unknown origin and fever. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.07.017DOI Listing
February 2019
5 Reads

Oncologic outcomes with transoral robotic surgery for supraglottic squamous cell carcinoma: Results of the French Robotic Surgery Group of GETTEC.

Head Neck 2018 Sep 26;40(9):2050-2059. Epub 2018 Jul 26.

Department of Head and Neck Surgery, Hospices Civils de Lyon, University Hospital Lyon-Nord, Lyon, France.

Background: Transoral robotic surgery (TORS) is an option to treat supraglottic squamous cell carcinomas (SCCs). We studied the oncologic outcomes after TORS for supraglottic laryngectomy (SGL).

Methods: We conducted a multicenter observational study of SGL using TORS for patients with supraglottic SCC with at least 2 years of follow-up. Read More

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http://dx.doi.org/10.1002/hed.25199DOI Listing
September 2018
2 Reads

The role of E-cadherin and β-catenin in laryngeal cancer.

Oncotarget 2018 07 10;9(53):30199-30209. Epub 2018 Jul 10.

Department of Head and Neck Surgery, São Paulo School of Medicine, University of São Paulo, São Paulo, Brazil.

Epithelial cadherins with catenins form the E-cadherin-catenin complex that acts on cell-to-cell adhesion. The loss of these complex lead to the reduction or absence of epithelial cadherin expression in the cell membrane, cytoplasmic accumulation of β-catenin and its translocation to the nucleus, contributing to carcinogenic events. The objective of this study was to evaluate the expression of epithelial cadherin and β-catenin in patients with laryngeal tumor. Read More

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http://dx.doi.org/10.18632/oncotarget.25680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059017PMC
July 2018
5 Reads

Warthin tumor of the larynx: A case report and review of the literature.

Ear Nose Throat J 2018 Jul;97(7):E8-E11

Corresponding author: Rambam Medical Center, Technion, Israel Institute of Technology, 6 Ha'Aliya St., PO Box 9602, Haifa 31096, Israel.

Warthin tumor (papillary cystadenoma lymphomatosum) is a benign salivary gland tumor that occurs almost exclusively in the parotid gland. As far as we know, only 15 cases of laryngeal Warthin tumor have been previously reported worldwide. We describe the case of a 75-year-old woman with a supraglottic tumor that mimicked a mucoepidermoid carcinoma. Read More

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July 2018
3 Reads

Radiotherapy dose-volume parameters predict videofluoroscopy-detected dysphagia per DIGEST after IMRT for oropharyngeal cancer: Results of a prospective registry.

Radiother Oncol 2018 09 28;128(3):442-451. Epub 2018 Jun 28.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address:

Purpose: Our primary aim was to prospectively validate retrospective dose-response models of chronic radiation-associated dysphagia (RAD) after intensity modulated radiotherapy (IMRT) for oropharyngeal cancer (OPC). The secondary aim was to validate a grade ≥2 cut-point of the published videofluoroscopic dysphagia severity (Dynamic Imaging Grade for Swallowing Toxicity, DIGEST) as radiation dose-dependent.

Material And Methods: Ninety-seven patients enrolled on an IRB-approved prospective registry protocol with stage I-IV OPC underwent pre- and 3-6 month post-RT videofluoroscopy. Read More

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http://dx.doi.org/10.1016/j.radonc.2018.06.013DOI Listing
September 2018
10 Reads

Prognosis of subglottic carcinoma: Is it really worse?

Head Neck 2019 Feb 26;41(2):511-521. Epub 2018 Jun 26.

Coordinator of the International Head and Neck Scientific Group.

It is traditionally accepted that subglottic carcinoma has a worse prognosis than tumors arising in other subsites of the larynx, owing to its tendency to present in advanced stages, with a high incidence of cartilage invasion and extralaryngeal spread. The incidence of subglottic carcinoma varies among series, mainly because there is no uniform definition of the upper boundary of the subglottis. The extent of the tumor may be difficult to define because subglottic carcinoma may spread through the submucosa without visible mucosal changes. Read More

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http://dx.doi.org/10.1002/hed.25172DOI Listing
February 2019
5 Reads

The management of the oropharyngeal anterior wall cancer.

Rom J Morphol Embryol 2018 ;59(1):113-119

Department of Preclinical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, Romania; Department of Ophthalmology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Introduction: Anterior wall of the oropharynx or the base of the tongue is the site of different types of cancers, most of them usually diagnosed in advanced stages. The most common histological type of cancer diagnosed in these patients is squamous cell carcinoma (SCC). The treatment methods are multiple, but the optimal therapeutic option with best results on outcome and on the patients' quality life has not been established. Read More

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October 2018
36 Reads

Robotic Head and Neck Surgery: History, Technical Evolution and the Future.

ORL J Otorhinolaryngol Relat Spec 2018 20;80(3-4):117-124. Epub 2018 Jun 20.

Department of Otorhinolaryngology and Head and Neck Surgery, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.

The first application of robotic technology in surgery was described in 1985 when a robot was used to define the trajectory for a stereotactic brain biopsy. Following its successful application in a variety of surgical operations, the da Vinci® robot, the most widely used surgical robot at present, made its clinical debut in otorhinolaryngology and head and neck surgery in 2005 when the first transoral robotic surgery (TORS) resections of base of tongue neoplasms were reported. Subsequently, the indications for TORS rapidly expanded, and they now include tumours of the oropharynx, hypopharynx, parapharyngeal space, and supraglottic larynx, as well as obstructive sleep apnoea (OSA). Read More

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http://dx.doi.org/10.1159/000489464DOI Listing
June 2018
17 Reads

The LAS VEGAS risk score for prediction of postoperative pulmonary complications: An observational study.

Eur J Anaesthesiol 2018 09;35(9):691-701

From the Hospital Israelita Albert Einstein, São Paulo, Brazil (ASN, LGVC), Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands (SNTH), Hospital Universitari Germans Trias I Pujol, Barcelona, Spain (JC), University Hospital Uppsula, Uppsala, Sweden (GH), Saint Eloi University Hospital, Montpellier, France (SJ), Medical University Vienna, Vienna, Austria (MH,WS), Academic Medical Center, Amsterdam, the Netherlands (MWH, MJS), Sheffield Teaching Hospitals, Sheffield, UK (GHM), Massachusetts General Hospital, Boston, USA (MFVM), Queen Mary University of London, London, UK (RP), University Hospital Bonn, Bonn, Germany (CP), University of Insubria, Varese, Italy (PS), University of Leipzig, Leipzig, Germany (HW), University Hospital Dresden, Dresden, Germany (MGA), Ospedale Policlinico San Martino - IRCCS per l'Oncologia, University of Genoa, Genoa, Italy (PP).

Background: Currently used pre-operative prediction scores for postoperative pulmonary complications (PPCs) use patient data and expected surgery characteristics exclusively. However, intra-operative events are also associated with the development of PPCs.

Objective: We aimed to develop a new prediction score for PPCs that uses both pre-operative and intra-operative data. Read More

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http://dx.doi.org/10.1097/EJA.0000000000000845DOI Listing
September 2018
34 Reads

Transoral Laser Microsurgery for Supraglottic Cancer.

Front Oncol 2018 9;8:158. Epub 2018 May 9.

Institute of Medical Informatics and Statistics, Christian-Albrechts-University Kiel, Kiel, Germany.

Introduction: Transoral laser microsurgery (TLM) is an accepted and effective treatment strategy for supraglottic carcinomas. Early supraglottic carcinoma has excellent outcomes independently of the treatment approach. The role of TLM for the treatment of locally advanced tumors is debated. Read More

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http://dx.doi.org/10.3389/fonc.2018.00158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954241PMC
May 2018
25 Reads

A 9-year analysis of transoral laser microsurgery (TLM) of head and neck cancer on their potential suitability for transoral robotic surgery (TORS) for estimation of future TORS-specific caseload.

Eur Rev Med Pharmacol Sci 2018 May;22(10):2949-2953

Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsklinikum Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany.

Objective: After that the establishment of transoral robotic surgery (TORS) for head and neck cancer has been adopted in North America, it has also recently been adopted in Europe. In these parts, transoral laser microsurgery (TLM) is widely applied. The aim of the study was to identify the absolute number of operations amenable to TORS at a TORS initiating institution on the basis of all former TLM cases. Read More

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http://dx.doi.org/10.26355/eurrev_201805_15049DOI Listing
May 2018
1 Read

[Laryngeal undifferentiated soft-tissue sarcoma: a case report and review of literature].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Aug;31(15):1205-1208

Patient presented as a 74-year-old male complaining of hoarseness. Electronic laryngoscope showed a neoplasm whose size was about 1.0 cm×0. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2017.15.016DOI Listing
August 2017
1 Read