2,287 results match your criteria Supraglottic Cancer

Swallowing function after transoral surgery for laryngopharyngeal cancer.

PLoS One 2022 24;17(6):e0270509. Epub 2022 Jun 24.

Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Transoral surgery (TOS) has been widely used to treat laryngopharyngeal cancers. Although TOS is a minimally invasive procedure, postoperative complications, such as postoperative dysphagia, may occur, which can lead to a poor quality of life for patients undergoing TOS. This study aimed to investigate factors that may affect swallowing function in patients who underwent TOS for laryngopharyngeal cancers. Read More

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Comparative evaluation of Intubating Laryngeal Mask Airway (ILMA), I-gel and Ambu AuraGain for blind tracheal intubation in adults.

J Anaesthesiol Clin Pharmacol 2022 Jan-Mar;38(1):130-136. Epub 2021 Sep 21.

Department of Neuroanaesthesia and Critical Care, AIIMS, Delhi, India.

Background And Aims: The supraglottic airway devices (SADs) that allow direct (without an intermediary device like Aintree or airway exchange catheters) tracheal intubation can be invaluable for field use in conditions ideally managed by intubation. Whilst fiberscope-guided intubation is the method of choice, if these 'direct-intubation' SADs could provide high success rates for blind tracheal intubation, their scope of use can increase tremendously. Our study assesses intubating laryngeal mask airway (ILMA), i-gel and Ambu AuraGain for blind tracheal intubation in adults. Read More

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September 2021

Delineation of neck node levels for patients with locally advanced supraglottic cancer receiving radical intensity-modulated radiotherapy: a cross-sectional study in Mainland China.

Future Oncol 2022 Jun 15. Epub 2022 Jun 15.

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China.

To survey the diversity of clinical target volumes (CTVs) for locally advanced supraglottic cancer (LA-SGC) with radical radiotherapy in mainland China. Radiation oncologists from 30 provinces and four representative cases (T2N1, T3N2b, T4N0, T4N2c) were included. High risk (HR)-CTV included involved and the lower adjacent level was followed by most physicians (n = 160, 97. Read More

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Infected Thyroglossal Duct Cyst in a Neonate: A Report of a Rare Case.

Am J Case Rep 2022 Jun 6;23:e936659. Epub 2022 Jun 6.

Department of Medical Education, University of Central Florida College of Medicine, Orlando, FL, USA.

BACKGROUND Thyroglossal duct cysts are the most common congenital cervical anomalies, often presenting as midline neck cysts. The mean age of presentation of pediatric thyroglossal duct cysts varies between 5 and 9 years old, with rare cases younger than 1 year old. This case report details a rare case of an infected thyroglossal duct cyst presenting during the neonatal period as an upper airway obstruction. Read More

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Complete remission of an early-stage laryngeal cancer under combined pembrolizumab and chemotherapy treatment of a synchronous lung adenocarcinoma.

J Otolaryngol Head Neck Surg 2022 May 16;51(1):21. Epub 2022 May 16.

Department of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, Kirrbergerstr. 100, Building 6, 66421, Homburg/Saar, Germany.

Background: Anti-PD1-Checkpoint inhibition (CI) is an established treatment of recurrent and/or metastatic head and neck cancer. A potential benefit from CI in early-stage disease that is usually treated by radiation or surgery has not been investigated so far and is currently not addressed in clinical trials.

Case Presentation: A 58-year-old man was diagnosed with a cT2 supraglottic laryngeal cancer and a synchronous metastasized adenocarcinoma of the lung. Read More

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[Larynx preservation: recommendations for decision-making in T3 laryngeal cancer patients].

HNO 2022 May 16. Epub 2022 May 16.

Heidelberger Institut für Global Health, Universität Heidelberg, Heidelberg, Deutschland.

Background: By today's standard, the optimal treatment of every individual tumor patient is discussed and determined in an interdisciplinary tumor board. According to the new S3 guidelines, larger volume T3 laryngeal cancers which are no longer safely resectable with larynx-sparing surgery are ideal candidates for a larynx preservation approach using primary chemoradiation (pCRT). So far, no clear criteria have been defined under what circumstances primary radiotherapy alone (pRT) might be acceptable in case chemotherapy (CT) is prohibited or in what cases, even in T3, upfront total laryngectomy with risk-adapted adjuvant treatment (TL±a[C]RT) should be recommended. Read More

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Transoral Laser Microsurgery With Neck Dissection Versus Radiotherapy for T2N0 Supraglottic Cancer.

Laryngoscope 2022 May 12. Epub 2022 May 12.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California-San Diego, La Jolla, California, USA.

Objectives: To compare overall survival outcomes associated with transoral laser microsurgery (TLM) with neck dissection versus definitive radiotherapy in the management of T2N0 supraglottic squamous cell carcinoma.

Methods: Data were extracted from the National Cancer Database concerning patients with cT2N0M0 supraglottic cancer treated with either TLM and neck dissection with minimum lymph node yield of 10 or definitive radiotherapy. Predictors of overall survival were assessed via Cox proportional hazards regression. Read More

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Laryngeal solitary fibrous tumour: diagnostic challenge in a rare presentation.

Ann R Coll Surg Engl 2022 Apr 21. Epub 2022 Apr 21.

The Princess Alexandra Hospital NHS Trust, UK.

Solitary fibrous tumours (SFT) are rare spindle cell mesenchymal neoplasms, most commonly appearing as well-circumscribed localised lesions arising from the abdominal or pelvic peritoneum. Their presence in the head and neck region is very rare; even more so in the post-cricoid region, with only one case described in the literature to date. The clinical behaviour of SFT may vary from benign to malignant, but only 10-15% of SFT demonstrate local recurrence or distant metastasis. Read More

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Supraglottic airway device versus tracheal intubation in the initial airway management of out-of-hospital cardiac arrest: the AIRWAYS-2 cluster RCT.

Health Technol Assess 2022 04;26(21):1-158

Clinical Trials and Evaluation Unit, Bristol Trials Centre, University of Bristol, Bristol, UK.

Background: When a cardiac arrest occurs, cardiopulmonary resuscitation should be started immediately. However, there is limited evidence about the best approach to airway management during cardiac arrest.

Objective: The objective was to determine whether or not the i-gel (Intersurgical Ltd, Wokingham, UK) supraglottic airway is superior to tracheal intubation as the initial advanced airway management strategy in adults with non-traumatic out-of-hospital cardiac arrest. Read More

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Preoperative tracheotomy in the treatment of upper airway obstruction of patients with advanced stage supraglottic carcinoma.

Am J Otolaryngol 2022 May-Jun;43(3):103381. Epub 2022 Feb 3.

Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China. Electronic address:

Background: Preoperative tracheotomy is an effective option that secures upper airway patency in laryngeal carcinoma patients suffering from upper airway obstruction, but the influence of this treatment on oncologic outcomes of laryngeal carcinoma remains controversial. The purpose of this study was to determine the impact of preoperative tracheotomy on overall survival in supraglottic carcinoma patients with tumor obstruction of the upper airway, and explore the potential causes.

Materials And Methods: This retrospective study collected 243 consecutive patients with advanced stage supraglottic carcinoma from 2005 to 2010. Read More

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A Predictive Nomogram for Lymph Node Metastasis in Supraglottic Laryngeal Squamous Cell Carcinoma.

Front Oncol 2022 2;12:786207. Epub 2022 Mar 2.

Department of Otolaryngology, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.

Purpose: Lymph node metastasis (LNM) has a negative impact on the survival of patients with laryngeal squamous cell carcinoma (LSCC). Supraglottic LSCC is the most common cause of cervical lymph node metastases due to the extensive submucosal lymphatic plexus. The accurate evaluation of LNM before surgery can inform improved decisions in the clinic. Read More

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Immune-Mediated Myopathy in a Patient Presenting for Melanoma Resection and Sentinel Lymph Node Biopsy.

Cureus 2022 Mar 2;14(3):e22777. Epub 2022 Mar 2.

Anesthesiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, USA.

Statin-induced necrotizing autoimmune myopathy (SINAM) is a rare side effect in people who are taking a class of drugs called statins. Patients with SINAM will present with subacute severe symmetric proximal muscle weakness. In contrast to more common myopathies, SINAM may not spontaneously resolve with statin discontinuation. Read More

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Pulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates.

Sci Transl Med 2022 03 9;14(635):eabm8646. Epub 2022 Mar 9.

School of Medicine, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.

Impaired baseline lung function is associated with mortality after pediatric allogeneic hematopoietic cell transplantation (HCT), yet limited knowledge of the molecular pathways that characterize pretransplant lung function has hindered the development of lung-targeted interventions. In this study, we quantified the association between bronchoalveolar lavage (BAL) metatranscriptomes and paired pulmonary function tests performed a median of 1 to 2 weeks before allogeneic HCT in 104 children in The Netherlands. Abnormal pulmonary function was recorded in more than half the cohort, consisted most commonly of restriction and impaired diffusion, and was associated with both all-cause and lung injury-related mortality after HCT. Read More

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En Bloc Resection of Supraglottic Carcinomas with Transoral Laser Microsurgery.

Turk Arch Otorhinolaryngol 2021 Dec 22;59(4):282-288. Epub 2022 Feb 22.

Department of Otorhinolaryngology, Ege University Faculty of Medicine, İzmir, Turkey.

Objective: Complete en bloc supraglottic tumor excision with transoral laser microsurgery (TLM) can be achieved with good postoperative outcomes. We report surgical feasibility and the postsurgical outcomes of en bloc resection of supraglottic laryngeal squamous cell carcinomas (LSCC) with TLM.

Methods: Seventeen patients who underwent TLM for supraglottic laryngeal cancer were included in the study. Read More

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December 2021

Prevalence of HPV Infection and p16 Overexpression in Surgically Treated Laryngeal Squamous Cell Carcinoma.

Vaccines (Basel) 2022 Jan 27;10(2). Epub 2022 Jan 27.

Otolaryngology Division, Azienda Ospedaliero Universitaria di Sassari, 07100 Sassari, Italy.

The mucosal high-risk (HR) human papillomavirus (HPV) is associated with oropharyngeal carcinogenesis. Aims of this study were to evaluate the prevalence of HR-HPV infection in laryngeal squamous cell carcinoma (LSCC) from different subsites, and the clinico-biological meaning of p16 overexpression. Ninety-seven LSCCs submitted to primary surgery ( = 75) or to post-irradiation salvage laryngectomy ( = 22) were evaluated for HR-HPV DNA and RNA using Luminex-based assays. Read More

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January 2022

Scanning Super/Ultrapulsed CO Laser Efficacy in Laryngeal Malignant Lesions.

Medicina (Kaunas) 2022 Jan 28;58(2). Epub 2022 Jan 28.

Pathology Department, "A. Murri" Hospital-ASUR Marche, Aree Vaste n. 4 and 5, 63900 Fermo, Italy.

The authors review their experience in transoral laryngeal microsurgery (TLM) that they performed with two different CO laser devices from the same company, which were both equipped with a micromanipulator and digital scanner. A total of 91 glottic and glotto-supraglottic cancers were treated during the years 2009-2016 and then analyzed in relation to the laser performances and the long-term oncologic results. Laser devices proved to be very efficient and the UP mode was confirmed to be the best in terms of cutting precision and lowest thermal damage. Read More

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January 2022

Laryngeal Schwannoma, Alarming Mass of Airway: A Case Report.

JNMA J Nepal Med Assoc 2021 Nov 15;59(243):1185-1188. Epub 2021 Nov 15.

Department of Emergency Medical Services, Government of Maldives, Ministry of Health Male, Maldives.

Laryngeal schwannomas are rare tumors of neural sheath origin. They normally present as a slow-growing, encapsulated, submucosal mass commonly in the supraglottic region. We describe a 13-year-old boy presenting with a 4-month history of progressive worsening dysphagia. Read More

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November 2021

Early death in supraglottic laryngeal squamous cell carcinoma: A population-based study.

Ear Nose Throat J 2022 Feb 16:1455613221078184. Epub 2022 Feb 16.

Department of Otolaryngology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, P. R. China.

Background: Supraglottic laryngeal squamous cell carcinoma (LSCC) is the second most common type of laryngeal cancer with a poor prognosis. Current population-based estimates of the early death rate and associated factors for early death of supraglottic LSCC are lacking. The purpose of this study was to assess the early death rate and related factors for early death in patients with supraglottic LSCC. Read More

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February 2022

Correlating muscle resection with functional swallow outcomes: An anatomic framework informed systematic review of the literature.

Am J Otolaryngol 2022 Mar-Apr;43(2):103386. Epub 2022 Feb 3.

Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, United States. Electronic address:

Objective: To perform a systematic review of studies reporting swallow-associated outcomes in patients who received surgery for head and neck cancer (HNC), informed by an anatomic and physiologic framework of pharyngeal phase of swallowing (Pearson's dual-sling model).

Methods: PUBMED and Google Scholar databases were searched for peer-reviewed papers published between 1990 and 2019 using relevant MeSH terms. Exclusion criteria were 1) discussions comparing reconstruction techniques, 2) case-report/series (n < 10), 3) perspective articles, 4) papers comparing objective instrumental methods of swallowing evaluation, 5) animal/cadaver studies, 6) no instrumental or validated swallow assessment tools used, 7) papers that discuss/include radiotherapy treatment, 8) systematic reviews, 9) papers that discuss swallow training or rehabilitation methods. Read More

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Childhood Respiratory Conditions: Stridor.

Jonathan Skirko

FP Essent 2022 Feb;513:25-31

Division of Otolaryngology in the Department of Pediatrics at University of Arizona College of Medicine, 1501 N. Campbell Ave, Tucson, AZ 85724.

The most important issue in diagnosing stridor in infants and children is determining whether it is acute or chronic. The most common cause of acute stridor is croup, a viral infection with a straightforward diagnosis when patients have typical signs and symptoms (ie, inspiratory or biphasic stridor, barking cough, hoarse voice or cry, chest wall retractions). Management of mild and severe cases includes steroids. Read More

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February 2022

Convulsive Syncope From Carotid Sinus Syndrome as a Manifestation of Laryngeal Cancer.

Ann Otol Rhinol Laryngol 2022 Feb 7:34894221076573. Epub 2022 Feb 7.

Department of Otorhinolaryngology - Head and Neck Surgery, Changi General Hospital, Singapore.

Objective: Carotid sinus syndrome (CSS) is a rare yet serious presentation of head and neck malignancy. To our knowledge, syncope and seizure-like episodes as a manifestation of carotid sinus syndrome secondary to laryngeal cancer has not been reported to date. We report a case of laryngeal cancer causing convulsive syncope masquerading as seizures due to CSS. Read More

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February 2022

Health-Related Quality-of-Life Outcomes after Transoral Robotic Surgery for T1 and T2 Supraglottic Laryngeal Carcinoma Compared to the Transcervical Open Supraglottic Approach.

ORL J Otorhinolaryngol Relat Spec 2022 Feb 7:1-9. Epub 2022 Feb 7.

Department of Otolaryngology Head and Neck Surgery, Health Science University, Bakırköy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.

Introduction: This prospective controlled study evaluated and compared health-related quality of life (HRQOL), after transoral robotic supraglottic laryngectomy (TORSGL) versus transcervical open supraglottic laryngectomy (TCOSGL) in patients with T1 and T2 supraglottic laryngeal carcinoma (SLC).

Methods: The TORSGL group comprised 14 patients, and the TCOSGL group comprised 13 patients. All 27 patients completed the European Organization for Research and Treatment of Cancer 30-item core quality-of-life questionnaire version 3. Read More

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February 2022

Investigation of the Effect of Radiotherapy Dose on Chewing and Swallowing Structures in Head and Neck Cancer Patients Treated with Concomitant Chemoradiotherapy.

Dysphagia 2022 Jan 25. Epub 2022 Jan 25.

Department of Speech and Language Therapy, Faculty of Health Sciences, Hacettepe University, Sıhhiye, 06230, Ankara, Turkey.

Intensity-modulated radiotherapy (IMRT) is a treatment method that is used in the treatment of head and neck cancers. Impairment of chewing and swallowing functions in the early and late periods of radiotherapy is frequent. Therefore, revealing the dose-effect relationship is important. Read More

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January 2022

Imaging response assessment for predicting outcomes after bioselection chemotherapy in larynx cancer: A secondary analysis of two prospective trials.

Clin Transl Radiat Oncol 2022 Mar 23;33:30-36. Epub 2021 Dec 23.

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States.

Background And Purpose: Bioselection with induction chemotherapy in larynx cancer is associated with excellent larynx preservation and disease-specific survival but requires visual inspection of the primary tumor. We retrospectively compare clinical and imaging response in bioselected patients to develop predictive models of surgeon-assessed response (SR), laryngectomy-free survival (LFS), and overall survival (OS) in bioselected patients.

Materials And Methods: In a secondary analysis of patients on two single-institution bioselection trials, model building used a regularized regression model (elastic-net) and applied nested cross-validation. Read More

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Mucoepidermoid Carcinomas of the Larynx.

Ann Otol Rhinol Laryngol 2022 Jan 6:34894211069459. Epub 2022 Jan 6.

Oregon Health and Science University School of Medicine, Portland, OR, USA.

Objectives: Discussions regarding the specific management and outcomes for laryngeal MEC are limited to very small, single-institution case series. To look further into the diagnosis and management of these uncommon non-squamous cell carcinomas of the larynx, we present 3 recent cases of laryngeal MEC treated at our institution.

Methods: Patients at a tertiary hospital treated for MEC between October 2019 and December 2020 were retrospectively identified. Read More

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January 2022

Airway Management Failure after Delayed Extubation in a Patient with Oral Malignant Melanoma Who Underwent Partial Mandibulectomy and Reconstruction with a Free Flap.

Case Rep Dent 2021 22;2021:7792843. Epub 2021 Dec 22.

Department of Anaesthesiology and Pain Medicine, Dankook University Hospital, Cheonan, Republic of Korea.

Maxillofacial surgery may cause severe complications in perioperative airway management. We report a case of failed airway management in a patient who underwent segmental mandibulectomy, radical neck dissection, and reconstruction with a free flap. The patient was extubated approximately 36 hours after surgery. Read More

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December 2021

Presentation and outcomes of patients with clinically T1-2, N0 supraglottic squamous cell carcinoma: The role of definitive radiotherapy compared to primary partial laryngectomy.

Head Neck 2022 03 29;44(3):735-744. Epub 2021 Dec 29.

Department of Otolaryngology - Head & Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Background: Early-stage supraglottic squamous cell carcinoma (SCC) is usually treated with a single modality. The aim of this study is to examine the role of radiotherapy (RT) versus partial laryngectomy (open, robotic-assisted, or endoscopic) with elective neck dissection (PL + END).

Methods: A retrospective analysis of the National Cancer Database, 2010-2016. Read More

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Pre-Treatment Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Predictors of Occult Cervical Metastasis in Clinically Negative Neck Supraglottic and Glottic Cancer.

J Pers Med 2021 Nov 25;11(12). Epub 2021 Nov 25.

Maxillo-Facial and ENT Surgery Unit, INT-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.

Among patients with diagnosis of Laryngeal Squamous Cell Carcinoma (LSCC), up to 37.5% of cases may have occult metastasis (OM), and this feature is linked to poor prognosis and high rate of local recurrence. The role of elective neck dissection (END) in clinically negative neck (cN0) LSCC remains controversial. Read More

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November 2021

TransOral UltraSonic surgery (TOUSS) for oral cavity, oropharyngeal and supraglottic malignancy: A prospective study of feasibility, safety, margins, functional and survival outcomes.

Oral Oncol 2022 01 11;124:105643. Epub 2021 Dec 11.

Department of Radiotherapy, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Introduction/background: With the advent of TransOral Robotic Surgery (TORS) the ease of transoral procedures has been dramatically improved. TORS is already established for its feasibility, functional and oncological outcomes for selected lesions of oral cavity, oropharynx and laryngopharynx. This study reports on preliminary results with TransOral UltraSonic Surgery (TOUSS) for oncologic resections of oral cavity, oropharyngeal and supraglottic malignancies. Read More

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January 2022

[Risk and prognostic analysis of cervical lymph node metastasis in cN+ laryngeal squamous cell carcinoma].

Hao Zhang Guohua Hu

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Dec;35(12):1115-1119;1123

Department of Otorhinolaryngology,First Affiliated Hospital of Chongqing Medical University,Chongqing,400016,China.

To analyze the clinical, pathological features and metastatic regularity of cervical lymph node metastasis in cN+ laryngeal squamous cell carcinoma, and to explore its diagnosis and management. Among 1030 patients with laryngeal squamous cell carcinoma who underwent surgery in the Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University from March 2011 to January 2021, 83 patients with cN+ were included in the retrospective analysis of clinical data and follow-up data. Among the 83 cases of cN+ laryngeal carcinoma, there were pN+65 cases and pN-18 cases. Read More

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December 2021