59,900 results match your criteria Supportive Cancer Therapy[Journal]
Cognition 2018 Dec 14;184:28-43. Epub 2018 Dec 14.
Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; Developmental Psychology, Utrecht University, Utrecht, the Netherlands; Brain Center Rudolf Magnus, University Medical Center, Utrecht, the Netherlands.
Gaze allocation to human faces has recently been shown to be greatly dependent on the social context. However, what has not been considered explicitly here, is how gaze allocation may be supportive of the specific task that individuals carry out. In the present study, we combined these two insights. Read More
Am J Clin Oncol 2018 Dec 14. Epub 2018 Dec 14.
Department of Obstetrics and Gynecology, Section of Gynecologic Oncology.
Background: The Multinational Association of Supportive Care of Cancer (MASCC) risk-index score has been validated as a stratification tool for febrile neutropenia (FN) risk in a heterogeneous group of cancer patients; recently, it has been deemed a suitable tool in gynecologic oncology patients in a retrospective study. This is a prospective multi-institutional study wherein we sought to validate MASCC score for stratifying FN morbidity in gynecologic oncology patients.
Methods: IRB approval was obtained at 4 institutions for prospective data collection of gynecologic cancer patients admitted with FN from 3/1/2013 to 9/1/2014. Read More
J Clin Child Adolesc Psychol 2018 Dec 17:1-13. Epub 2018 Dec 17.
a Department of Psychology and Human Development , Vanderbilt University.
Children require adult caregivers to survive and thrive. In the absence of committed and nurturing care, children face increased risk for a number of difficulties, including internalizing and externalizing psychopathology, cognitive and language deficits, and social difficulties. Recent changes in the U. Read More
J Med Biogr 2018 Dec 17:967772016685908. Epub 2018 Dec 17.
Department of Pharmacology and Toxicology, Jacobs School of Medicine, the State University of New York at Buffalo, Buffalo, NY, USA.
This article encapsulates the career of Joshua Burn, whose work encouraged new lines of experimentation and paved the way for fundamental advances in our knowledge of the autonomic nervous system. His legacy also endures in his efforts as Department Chairman to oversee a very supportive environment which led to the development of many successful scientists. By producing a body of work that enabled the discipline of pharmacology to contribute in a major way to the advancement of clinical medicine, Joshua Burn stands out as a unique figure in the annals of true scientific pioneers. Read More
Scand J Psychol 2018 Dec 16. Epub 2018 Dec 16.
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
In accordance with the Self-determination Theory (SDT), six dimensions of parenting (autonomy support vs. psychological control, structure vs. chaos, warmth vs. Read More
ACS Omega 2018 Nov 1;3(11):14634-14640. Epub 2018 Nov 1.
Analytical and Environmental Division and Centralized Instrument Facility and Academy of Scientific and Innovative Research (AcSIR), CSIR-Central Salt and Marine Chemicals Research Institute, Gijubhai Badheka Marg, Bhavnagar 364002, Gujarat, India.
A new synthetic approach is established where both TiO nanoparticles and glucose oxidase (GO ) are together encapsulated into the cavity of ZIF-8 metal-organic framework (MOF) to fabricate a mediator-free glucose sensor in aqueous media. ZIF-8 possesses high stability both physically and chemically. Moreover, its large surface area and tunable cavity size are supportive to encapsulate both nanoparticles (TiO) and enzymes (GO ). Read More
eNeurologicalSci 2019 Mar 22;14:19-20. Epub 2018 Nov 22.
Pennsylvania Hospital, 800 Spruce Street, Philadelphia, PA 19107, USA.
Fat embolism syndrome (FES) is a known complication of sickle cell disease (SCD) that occurs secondary to vaso-occlusive crises, bone marrow infarction, and the subsequent release of fat globules into the venous circulation. Although neurologic involvement is common, the pathophysiology of cerebral fat emboli remains controversial. While fat microemboli can enter the arterial circulation through right-to-left shunts, the systemic release of free fatty acids may also cause indirect endothelial damage and disruption of the blood-brain-barrier. Read More
Lancet Glob Health 2019 Jan;7(1):e96-e109
Department of Learning Health Sciences and Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Background: Several qualitative studies have described disrespectful, abusive, and neglectful treatment of women during facility-based childbirth, but few studies document the extent of person-centred maternity care (PCMC)-ie, responsive and respectful maternity care-in low-income and middle-income countries. In this Article, we present descriptive statistics on PCMC in four settings across three low-income and middle-income countries, and we examine key factors associated with PCMC in each setting.
Methods: We examined data from four cross-sectional surveys with 3625 women aged 15-49 years who had recently given birth in Kenya, Ghana, and India (surveys were done from August, 2016, to October, 2017). Read More
Dev Psychopathol 2018 Dec 17:1-13. Epub 2018 Dec 17.
Waisman Center, University of Wisconsin-Madison,Madison,WI,USA.
African American youths are overrepresented in the American juvenile justice system relative to Caucasians. Yet, research on antisocial behaviors (ASB) has focused on predominantly Caucasian populations. Furthermore, relatively little is known about how environmental factors, such as supportive parenting (e. Read More
J Clin Nurs 2018 Dec 16. Epub 2018 Dec 16.
Department of Nursing, Umeå University, Sweden.
Aims And Objectives: The aim of this study was to describe the perceptions that municipal primary health care nurses and municipal registered nurses had about a web-based learning intervention concerning supportive family health conversations in municipal home health care.
Background: Even though family health conversations is well grounded in theory with several reported benefits for patients and families, most working nurses have little or no training in practicing family systems nursing including family health conversations. Continued learning is necessarily for nurses, where web-based learning may be one answer of updating the professional skills and knowledge of nurses regarding supporting families. Read More
Support Care Cancer 2018 Dec 15. Epub 2018 Dec 15.
Department of Palliative Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka City, Osaka, 534-0021, Japan.
Purpose: Few studies have investigated nutrition impact symptoms and eating-related distress among advanced cancer patients and their families. This is a questionnaire survey to examine the severity of nutrition impact symptoms and the prevalence of eating-related distress among them in palliative and supportive care settings.
Methods: Questionnaires for patients and their families were preliminarily developed. Read More
Digestion 2018 Dec 14;99(1):52-58. Epub 2018 Dec 14.
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Background/aims: The outcomes of salvage surgery for recurrence after non-curative endoscopic submucosal dissection (ESD) without additional radical surgery for early gastric cancer (EGC) remain unclear. We determined the recurrence patterns and outcomes of salvage surgery in such cases using data from a multicenter, retrospective study.
Methods: Of 15,785 patients who underwent ESD for EGC at 19 participating institutions between January 2000 and August 2011, 1,969 failed to meet the current curative criteria after ESD. Read More
J Neurosurg 2018 Dec 14:1-7. Epub 2018 Dec 14.
OBJECTIVERevascularization surgery is a safe and effective surgical treatment for symptomatic moyamoya disease (MMD) and has been shown to reduce the frequency of future ischemic events and improve quality of life in affected patients. The authors sought to investigate the occurrence of acute perioperative occlusion of the contralateral internal carotid artery (ICA) with contralateral stroke following revascularization surgery, a rare complication that has not been previously reported.METHODSThis study is a retrospective review of a prospective database of a single surgeon's series of revascularization operations in patients with MMD. Read More
Nurse Educ Today 2018 Dec 7;74:7-14. Epub 2018 Dec 7.
National and Kapodistrian University of Athens, Athens, Greece.
Background: Ensuring adequate knowledge about palliative care and positive attitudes towards death and dying are crucial educational aspects when preparing undergraduate nursing students to respond effectively to the complexities of care for people affected by a progressive, life-limiting illness. In undergraduate nursing education in Greece, the level of students' attained knowledge and developed attitudes towards palliative and end-of-life care remain unknown.
Purpose: To investigate undergraduate nursing students' knowledge about palliative care and attitudes towards death and end-of-life care, and explore demographic and academic factors as potential moderators of student knowledge and attitudes. Read More
Differentiation 2018 Dec 6;105:27-32. Epub 2018 Dec 6.
Department of Hematology and Oncology, Medical Faculty, University of Leipzig, Leipzig, Germany.
Horse serum is commonly used as an additive to support the maintenance of hematopoietic progenitor cells in culture. However, the wide variability in the performance of different lots calls for parallel testing of multiple batches over extended periods of culture. Identification of the serum components that determine hematopoietic support would therefore save considerable time and effort and would help to standardize culture procedures. Read More
J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.
Department of Public Health, Section for Clinical Social Medicine and Rehabilitation, Faculty of Health, Aarhus University, Denmark.
Aims And Objectives: To explore patients' experiences and perspectives of their challenges and needs regarding their return to everyday life after allogeneic non-myeloablative haematopoietic stem cell transplantation (NMA-HSCT).
Background: NMA-HSCT can cure patients with malignant blood diseases, but during the following years the majority of patients suffer from serious side effects and complications. Hence, it is a major challenge for patients treated with NMA-HSCT to rehabilitate, maintain physical and psychosocial functioning and return to a life in restored balance. Read More
Pharmacoecon Open 2018 Dec 14. Epub 2018 Dec 14.
King's College Hospital National Health Service Foundation Trust, London, UK.
Background: Uncertainty within cost-effectiveness analysis, often driven by lack of mature data from large clinical trials, plays a key role in decisions made by the National Institute for Health and Care Excellence (NICE), particularly for early access medicines and orphan drugs.
Objectives: In this case study, we used real-world evidence to address the uncertainty in the cost-effectiveness case for lenalidomide in transfusion-dependent low- and intermediate-1-risk myelodysplastic syndrome (MDS) deletion 5q [del(5q)], affecting a small but unique subpopulation with an orphan disease.
Methods: As part of a submission to NICE, we developed a cost-effectiveness model for lenalidomide, resulting in eventual recommendation. Read More
BMJ Open 2018 Dec 14;8(12):e022548. Epub 2018 Dec 14.
Wessex Institute, University of Southampton, Southampton, UK.
Objectives: Innovations resulting from research have both national and global impact, so selecting the most promising research studies to fund is crucial. Peer review of research funding applications is part of the selection process, and requires considerable resources. This study aimed to elicit stakeholder opinions about which factors contribute to and influence effective peer review of funding applications to the UK National Institute for Health Research (NIHR), and to identify possible minor improvements to current processes and any major changes or potential innovations to achieve a more efficient peer review process. Read More
Curationis 2018 Dec 3;41(1):e1-e11. Epub 2018 Dec 3.
School of Nursing and Public Health, University of KwaZulu-Natal.
Background: Globally, there is consensus on the need for student support to address high student attrition and low throughputs, especially in nursing and midwifery programmes.
Objectives: This study analysed the implementation of academic monitoring and support (AMS) in an undergraduate nursing programme to generate a context-informed academic monitoring and support middle-range theory.
Method: An ethnographic design and grounded theory approach were adopted in this study. Read More
Sci Total Environ 2018 Dec 4;657:379-390. Epub 2018 Dec 4.
Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, Pisa 56124, Italy; CIRSEC, Centre for Climatic Change Impact, University of Pisa, Via del Borghetto 80, Pisa 56124, Italy.
There is a lack of knowledge about the possibility that plants facing abiotic stressors, such as drought, have an altered perception of a pulse of O and incur in alterations of their signalling network. This poses some concerns as to whether defensive strategy to cope episodic O peaks in healthy plants may fail under stress. In this study, a set of saplings of two Mediterranean deciduous species, Quercus cerris and Q. Read More
Annu Rev Clin Psychol 2018 Dec 14. Epub 2018 Dec 14.
Department of Clinical, Neuro-, and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands; email:
Psychotherapies may work through techniques that are specific to each therapy or through factors that all therapies have in common. Proponents of the common factors model often point to meta-analyses of comparative outcome studies that show all therapies have comparable effects. However, not all meta-analyses support the common factors model; the included studies often have several methodological problems; and there are alternative explanations for finding comparable outcomes. Read More
PLoS One 2018 14;13(12):e0208814. Epub 2018 Dec 14.
Institute for Global Health Sciences, University of California, San Francisco, San Francisco, California, United States of America.
Objectives: To determine whether supportive interventions can increase retention in care for patients on antiretroviral therapy (ART) in low- and middle-income countries (LMIC).
Design: Systematic review and meta-analysis.
Methods: We used Cochrane Collaboration methods. Read More
J Dev Behav Pediatr 2018 Dec 13. Epub 2018 Dec 13.
Department of Pediatrics, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.
Objective: Intimate partner violence (IPV) can adversely affect children's cognitive development, but links between IPV exposure and language development in the earliest years of life remain unknown. The present study examined the effects of IPV and the quality of the home environment on children's language development at age 3 years.
Methods: In a prospective, 5-panel, longitudinal study of 79 mother-child dyads assessed prenatally to age 3 years, we examined standardized measures of receptive and expressive language development at age 3 years. Read More
J Nurs Care Qual 2018 Dec 12. Epub 2018 Dec 12.
School of Nursing, Sun Yat-sen University, Guangzhou, China.
Background: The mechanism of how work environments affect nurse outcomes and quality of care has not been studied in intensive care unit (ICU) settings.
Purpose: The purpose was to investigate the effects of work environment on nurse outcomes and quality of care in ICUs, through the mediating effects of nursing care left undone.
Methods: This study used survey data from 459 nurses from 22 ICUs in 22 hospitals in China. Read More
Risk Anal 2018 Dec 14. Epub 2018 Dec 14.
Social and Environmental Research Institute, Northampton, MA, USA.
Over the past four decades, the promise of public participation to improve decisions, obtain legitimacy, and build capacity for risk decision making and management has had a mixed record. In this article, we offer a narrative of how public participation has evolved in the United States and we examine prospects for its future. We trace three forces that have had significant impact on practice: an emergent emphasis on democratic deliberation, a transition from dichotomous thinking about science versus politics to an integrated perspective, and the recognition that different parties to the decision-making process bring valid epistemological contributions. Read More
J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.
Department of Nursing, Umeå University, SE -901 85, Umeå, Sweden.
Aims And Objectives: We aimed to explore patients' experiences of contact and interaction with healthcare professionals (HCPs) during the diagnostic process of melanoma.
Background: In Sweden, most patients with suspected skin lesions seek care at the primary level of services in the first instance. Previous research describe the diagnostic process as a complex journey with uncertainty. Read More
Br J Health Psychol 2018 Dec 13. Epub 2018 Dec 13.
School of Psychological Sciences, Tel Aviv University, Israel.
Objectives: Since behavioural risk factors are the foremost causes of disability and premature mortality, developing new perspectives for understanding them is of utmost importance. This paper describes an innovative approach that conceptualizes health-related behaviours as nodes in a weighted network.
Design & Methods: Using self-reported data from a representative sample (n = 374), a network of 37 health behaviours was analysed, with the aim of identifying 'central' nodes, that is, behaviours that are likely to co-occur with others and potentially influence them. Read More
Health Soc Care Community 2018 Dec 12. Epub 2018 Dec 12.
University of South Australia, Adelaide, South Australia, Australia.
The diagnostic process for children with autism can be complex for parents to navigate as they advocate for their child in order to obtain answers to their concerns, and receive the subsequent support they need. Gaining an understanding of parents' experiences during this process, will assist service providers in supporting families adequately. This systematic review was undertaken to consolidate in-depth qualitative data from parents of their experience of advocating for their child with autism, during the process of diagnosis. Read More
J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.
Department of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Tongji University, Shanghai, China.
The rapid bone remodeling after osteotomy has been reported for a long time. However, the underlying mechanism promoting the active bone reconstruction was still to be elucidated. Since not only the bone, blood vessels, and supportive tissues, but also the local microenvironment were destroyed, if the changes on the cell metabolism was contributed to the accelerated bone remodeling came into sight. Read More
J Midwifery Womens Health 2018 Dec 12. Epub 2018 Dec 12.
Introduction: Skin-to-skin care (SSC) immediately after birth is recommended for all women and their newborns. Barriers to SSC after cesarean birth lead to delays in initiation of this practice. The purpose of this quality improvement project was to implement an innovative approach with volunteer doulas to support initiation of SSC after cesarean for all clients. Read More
Oncol Nurs Forum 2019 Jan;46(1):49-58
City of Hope Comprehensive Cancer Center.
Purpose: To explore palliative care and oncology clinicians' perspectives on current challenges and facilitating factors in meeting the spiritual needs of patients with lung cancer and family caregivers. This study was conducted in preparation for a community-based lung cancer palliative care intervention.
Participants & Setting: 19 oncology and palliative care clinicians in three outpatient Kaiser Permanente sites in southern California. Read More
Oncol Nurs Forum 2019 Jan;46(1):92-103
University of Southern Queensland.
Objectives: To understand the context for implementing ProsCare by prostate cancer specialist nurses (PCSNs) and, in doing so, further develop the intervention and implementation strategy.
Sample & Setting: 30 PCSNs participated in four semistructured focus groups to evaluate a telephone-based supportive care intervention led by nurses for men with advanced prostate cancer.
Methods & Variables: Data were coded into the Consolidated Framework for Implementation Research to evaluate the ProsCare program content and guide the implementation and evaluation of this targeted program for men with advanced prostate cancer. Read More
J Comp Eff Res 2018 Dec 14. Epub 2018 Dec 14.
Evroston LP, Athens, Greece.
Aim: To evaluate the cost-effectiveness of trifluridine and tipiracil hydrochloride (FTD/TPI) compared with best supportive care (BSC) or regorafenib for the treatment of patients with metastatic colorectal cancer who have been previously treated with or are not considered candidates for available therapies including fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapies, anti-VEGF agents and anti-EGFR agents in Greece.
Methods: A partitioned survival model was locally adapted from a third-party payer perspective over a 10 year time horizon. Efficacy data and utility values were extracted from published studies. Read More
AIDS Behav 2018 Dec 13. Epub 2018 Dec 13.
North Carolina Department of Health and Human Services, Division of Public Health, Communicable Disease Branch, Raleigh, NC, 27603, USA.
Depression among persons with HIV is associated with antiretroviral therapy (ART) interruption and discontinuation, virological failure, and poor clinical and survival outcomes. Case management services can address needs for emotional counseling and other supportive services to facilitate HIV care engagement. Using 2009-2013 North Carolina Medical Monitoring Project data from 910 persons engaged in HIV care, we estimated associations of case management utilization with "probable current depression" and with 100% ART dose adherence. Read More
Front Immunol 2018 28;9:2798. Epub 2018 Nov 28.
Department of Tumor Immunology, Oncode Institute, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Biomaterial-based scaffolds are promising tools for controlled immunomodulation. They can be applied as three dimensional (3D) culture systems , whereas they may be used to dictate cellular localization and exert spatiotemporal control over cues presented to the immune system. As such, scaffolds can be exploited to enhance the efficacy of cancer immunotherapies such as adoptive T cell transfer, in which localization and persistence of tumor-specific T cells dictates treatment outcome. Read More
BMC Psychiatry 2018 Dec 13;18(1):388. Epub 2018 Dec 13.
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center for Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Background: The efficacy of parent-child training (PCT) regarding child symptoms may be reduced if the mother has attention-deficit/hyperactivity disorder (ADHD). The AIMAC study (ADHD in Mothers and Children) aimed to compensate for the deteriorating effect of parental psychopathology by treating the mother (Step 1) before the beginning of PCT (Step 2). This secondary analysis was particularly concerned with the additional effect of the Step 2 PCT on child symptoms after the Step 1 treatment. Read More
Pharmacy (Basel) 2018 Dec 9;6(4). Epub 2018 Dec 9.
College of Business, Western New England University, 1215 Wilbraham Road, Springfield, MA 01119, USA.
Not much is currently known about United States (US) physicians' opinions about healthcare financing, specifically subsequent to the creation and implementation of the Affordable Care Act (ACA). A four state survey of practicing US based physicians' opinions about healthcare financing following ACA passage and implementation. Physician leaders practicing in the state of New York, Texas, Colorado and Mississippi were surveyed. Read More
Int J Environ Res Public Health 2018 12 7;15(12). Epub 2018 Dec 7.
Department of Family Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
The COMmunity of Practice And Safety Support (COMPASS) program was developed to prevent injuries and advance the health and well-being of home care workers. The program integrates elements of peer-led social support groups with scripted team-based programs to help workers learn together, solve problems, set goals, make changes, and enrich their supportive professional network. After a successful pilot study and randomized controlled trial, COMPASS was adapted for the Oregon Home Care Commission's training system for statewide dissemination. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13304
Department of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
Rationale: Inflammatory demyelinating neuropathies such as Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and focal segmental glomerulosclerosis (FSGS) are autoimmune disorders that may have a common pathogenesis. Here, we describe 2 unique cases of FSGS, 1 with GBS and the other with CIPD. We believe that reviewing these multisystemic diseases will help in better understanding of FSGS pathogenesis. Read More
J Neurosurg 2018 Nov 1:1-6. Epub 2018 Nov 1.
OBJECTIVEData on the survival effects of supportive care compared to second-line multimodal treatment for glioblastoma progression are scarce. Thus, the authors assessed survival in two population-based, similar cohorts from two European university hospitals with different treatment strategies at first progression.METHODSThe authors retrospectively identified patients with newly diagnosed glioblastoma treated at two neurooncological centers. Read More
Klin Padiatr 2018 Dec 13. Epub 2018 Dec 13.
Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany.
Background: With improved survival rates in pediatric oncology, the detection of adverse side- and late-effects is gaining increased interest. This cross-sectional study investigated walking abilities and ankle dorsiflexion function in children with cancer.
Patients: Study participants included 16 children with various cancers (4-20 years, patient group) after completion of the intense treatment and 16 age- and gender-matched healthy peers (comparison group). Read More
Gerontologist 2018 Dec 13. Epub 2018 Dec 13.
Harvard Medical School, Boston, Massachusetts.
Background And Objectives: Older adults living in subsidized housing have typically been excluded from exercise intervention studies. We conducted a qualitative study to explore the perceived physical, psychological, social, and economic factors that influenced participation in and adherence to a year-long Tai Chi intervention within an ongoing cluster-randomized controlled trial (RCT) for older adults living within subsidized housing facilities.
Research Design And Methods: Focus groups were held with participants of the RCT who were allocated to the trial's Tai Chi intervention. Read More
J Clin Epidemiol 2018 Dec 10. Epub 2018 Dec 10.
Department of Pediatric Oncology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, the Netherlands. Electronic address:
Objectives: To evaluate in how many cancer-related Cochrane reviews hazard ratio (HR) based absolute effects in Summary of Findings (SoF) tables have been correctly calculated and reported.
Study Design: We identified all Cochrane cancer intervention reviews that reported a HR for at least one outcome and provided a SoF table, published between January 2011 and December 2017 in the Cochrane Database of Systematic Reviews (CDSR).
Results: In 28 reviews (29%) of 96 included Cochrane reviews absolute effects in the SoF tables were calculated in a correct manner. Read More
Biochim Biophys Acta Biomembr 2018 Dec 10. Epub 2018 Dec 10.
Department of Chemistry and Centre for Biotechnology, Brock University, St. Catharines, Ontario L2A 3S1, Canada. Electronic address:
Fluorescence resonance energy transfer (FRET) assays and membrane binding determinations were performed using three phosphatidylinositol transfer proteins, including the yeast Sec14 and two mammalian proteins PITPα and PITPβ. These proteins were able to specifically bind the fluorescent phosphatidylcholine analogue NBD-PC ((2-(12-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl-1-hexadecanoyl-sn-glycero-3-phosphocholine)) and to transfer it to small unilamellar vesicles (SUVs). Rate constants for transfer to vesicles comprising 100% PC were slower for all proteins than when increasing percentages of phosphatidylinositol were incorporated into the same SUVs. Read More
J Oncol Pract 2018 Dec 13:JOP1800315. Epub 2018 Dec 13.
Memorial Sloan Kettering Cancer Center, New York, NY.
Purpose:: A shift in outpatient oncology care from the physician's office to hospital outpatient settings has generated interest in the effect of practice setting on outcomes. Our objective was to examine whether medical oncologists' prescribing of drugs and services for older adult patients with advanced cancer is used more in physicians' offices compared with hospital outpatient departments.
Methods:: This was a retrospective comparative study. Read More
J Behav Med 2018 Dec 12. Epub 2018 Dec 12.
University of Utah, Salt Lake City, USA.
In a study of 199 couples in which one person had type 1 diabetes, we examined how patient appraisal of the diabetes as shared versus individual was associated with collaborative, supportive and unsupportive behavior and whether patient shared illness appraisal was most beneficial for health when it occurred in the context of supportive behavior. We assessed illness appraisal among patients with type 1 diabetes and their partners and had patients complete relationship and health measures. Results showed partners were more likely than patients to hold shared illness appraisals. Read More
Drugs 2018 Dec;78(18):1861-1872
Department of Medicine 1, Division of Hematology and Hemostasis, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Acquired hemophilia A (AHA) is a rare autoimmune disease caused by autoantibodies inhibiting the function of coagulation factor VIII. It is characterized by spontaneous bleeding in patients with no previous family or personal history of bleeding. Although several large registries have collected clinical data on AHA, limited information is available on the optimal management of AHA because controlled clinical trials are lacking. Read More
Front Oncol 2018 13;8:512. Epub 2018 Nov 13.
Department of Pathology, Yale University, New Haven, CT, United States.
In order to determine the role of human herpesvirus 6 (HHV-6) in human disease, several confounding factors, including methods of detection, types of controls, and the ubiquitous nature of the virus, must be considered. This is particularly problematic in the case of cancer, in which rates of detection vary greatly among studies. To determine what part, if any, HHV-6 plays in oncogenesis, a review of the literature was performed. Read More
Tech Orthop 2018 Dec 25;33(4):232-238. Epub 2017 Dec 25.
Melbourne Orthopaedic Group, Windsor, Vic., Australia.
In the anterior cruciate ligament (ACL) deficient knee, excellent outcomes are achieved in many patients with an isolated, intra-articular ACL reconstruction. Some patients, however, have ongoing instability or suffer graft rupture. Failure after ACL reconstruction is multifactorial, but residual anterolateral rotatory laxity is 1 potential contributing factor. Read More