Cell cycle-related kinase regulates mammalian eye development through positive and negative regulation of the Hedgehog pathway.
Dev Biol 2017 Nov 19. Epub 2017 Nov 19.
Department of Genetics, University of Georgia, Athens, GA 30602. Electronic address:
Cell cycle-related kinase (CCRK) is a conserved regulator of ciliogenesis whose loss in mice leads to a wide range of developmental defects, including exencephaly, preaxial polydactyly, skeletal abnormalities, and microphthalmia. Here, we investigate the role of CCRK in mouse eye development. Ccrk mutants show dramatic patterning defects, with an expansion of the optic stalk domain into the optic cup, as well as an expansion of the retinal pigment epithelium (RPE) into neural retina (NR) territory. Read More