725 results match your criteria Sunscreens and Photoprotection

Formulation of a new broad-spectrum UVB + UVA and blue light SPF50 sunscreen containing Phenylene Bis-Diphenyltriazine (TriAsorB), an innovative sun filter with unique optical properties.

J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6:29-37

Laboratoire Pierre Fabre, Centre R&D, Toulouse, France.

Accumulating evidence from numerous comprehensive studies has demonstrated that blue light, in particular high-energy visible light, can exert a range of harmful effects on skin cells. These forms of radiation are now known to be able to trigger oxidation reactions, DNA damage, erythema and pigmentary changes, and may also be associated with photoaging. Sunscreens protecting the skin from only ultraviolet (UV)-B and UVA rays can therefore no longer be regarded as sufficient to help prevent skin damage from sunlight, and products containing filters that can provide broad-spectrum photoprotection are required. Read More

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Dermatology: how to manage facial hyperpigmentation in skin of colour.

Drugs Context 2022 31;11. Epub 2022 May 31.

Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Hyperpigmentation disorders, such as post-inflammatory hyperpigmentation and melasma, are common conditions affecting all skin types. These conditions are largely benign and are influenced by numerous endogenous and exogenous factors impacting melanocyte activity and melanin production. Current treatment modalities for these conditions fall into broad categories, including photoprotection, topical and systemic therapies, chemical peels, and laser or light-based therapies. Read More

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Evaluation of an efficient and skin-adherent semisolid sunscreen nanoformulation.

Skin Pharmacol Physiol 2022 Jun 15. Epub 2022 Jun 15.

Introduction: Sunscreens are substances applied on the skin surface to protect the skin from the harmful effects of UV light. Nanoparticles can increase the retention time of the sunscreen on the skin surface and its efficacy, by acting as physical barriers. The present investigation aimed to prepare and characterize benzophenone-3-loaded lipid core nanocapsules coated with chitosan (CH-LNC) and, after obtaining a suitable semisolid formulation for skin application, to evaluate the influence of the nanocapsules chitosan-coating on the skin adhesion and photoprotective effect of the sunscreen. Read More

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Evaluation of efficacy of antioxidant-enriched sunscreen prodcuts against long wavelength ultraviolet A1 and visible light.

Int J Cosmet Sci 2022 May 19. Epub 2022 May 19.

Photomedicine and Photobiology Unit, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA.

Objective: The synergistic effects of VL and long wavelength UVA1 (VL + UVA1, 370-700 nm) on inducing pigmentation and erythema in skin have been demonstrated and linked to exacerbation of dermatologic conditions including melasma and post-inflammatory hyperpigmentation. This study aimed to compare the photoprotection of organic sunscreens enriched with antioxidant (AO) combinations against VL + UVA1 induced biologic effects. The efficacy was compared with that offered by a commercially available tinted sunscreen. Read More

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Evaluation of an SPF50 Sunscreen Containing Photolyase and Antioxidants for its Anti-Photoaging Properties and Photoprotection.

J Drugs Dermatol 2022 May;21(5):517-520

Background: Background: Skin exposure to ultraviolet radiation (UVR) causes DNA damage, which can lead to mutagenesis, carcinogenesis, cellular death, and photoaging. Signs of photoaging include wrinkling, erythema, skin laxity, uneven skin texture, and hyperpigmentation. Photolyase is an exogenous DNA repair enzyme that can restore DNA integrity when applied topically to human skin. Read More

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Assessing the frequency of adverse reactions induced by melanin-containing formulations used for the management of solar dermatitis.

J Cosmet Dermatol 2022 Apr 30. Epub 2022 Apr 30.

Department of Pharmacy, Medical Institute of Yerevan Haybusak University, Yerevan, Armenia.

Background: Melanin from different sources is widely used by many manufacturers to produce cosmetics and sunscreens. Research data show a wide spectrum of biological activities of melanin including the protection against UV radiation and oxidants. According to the research evidence, the topical use of melanin is more effective against inflammation than the hydrocortisone. Read More

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Expert Recommendations on the Evaluation of Sunscreen Efficacy and the Beneficial Role of Non-filtering Ingredients.

Front Med (Lausanne) 2022 31;9:790207. Epub 2022 Mar 31.

Department of Dermatology, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, China.

A variety of non-filtering agents have been introduced to enhance sunscreen photoprotection. Most of those agents have only weak erythema protective properties but may be valuable and beneficial in supporting protection against other effects of UV radiation, such as photoimmunosuppression, skin aging, and carcinogenesis, as well as photodermatoses. The question arises how to measure and evaluate this efficacy since standard SPF testing is not appropriate. Read More

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A Perspective on Femtosecond Pump-Probe Spectroscopy in the Development of Future Sunscreens.

J Phys Chem A 2022 Apr 8;126(15):2299-2308. Epub 2022 Apr 8.

Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom.

Given the negative impacts of overexposure to ultraviolet radiation (UVR) on humans, sunscreens have become a widely used product. Certain ingredients within sunscreens are responsible for photoprotection and these are known, collectively herein, as ultraviolet (UV) filters. Generally speaking, organic UV filters work by absorbing the potentially harmful UVR and dissipating this energy as harmless heat. Read More

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Benzophenone-3, a chemical UV-filter in cosmetics: is it really safe for children and pregnant women?

Postepy Dermatol Alergol 2022 Feb 28;39(1):26-33. Epub 2021 Feb 28.

Department of Monitored Pharmacotherapy, Medical University of Bialystok, Bialystok, Poland.

Children and adolescents are particularly vulnerable to skin damage caused by ultraviolet radiation and require intensified photoprotection. Benzophenone-3 (BP-3) belongs to the organic sunscreens, which are widely used in personal care and cosmetic products. However, the impact of BP-3 on human health requires a careful assessment. Read More

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February 2022

UV Filters: Challenges and Prospects.

Pharmaceuticals (Basel) 2022 Feb 22;15(3). Epub 2022 Feb 22.

UCIBIO-Applied Molecular Biosciences Unit, MedTech, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

The use of sunscreens is an established and recommended practice to protect skin from solar-induced damage. Around 30 UV filters can be used in sunscreen products in the European Union, which ought to follow the requirements of the regulation 1223/2009 to ensure their efficacy and safety for humans. Nevertheless, low photostability and putative toxicity for humans and environment have been reported for some UV filters. Read More

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February 2022

Melasma: The need for tailored photoprotection to improve clinical outcomes.

Photodermatol Photoimmunol Photomed 2022 Mar 1. Epub 2022 Mar 1.

Department of Dermatology, University Côte d'Azur, CHU Nice, Nice, France.

Background/purpose: Melasma is a frequent photoexacerbated hyperpigmentary disorder, which can significantly impact on the quality of life. We sought to review the pathogenesis of melasma, and the role of photoprotection in the prevention and treatment of this disorder.

Methods: We conducted a narrative review of the literature. Read More

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A new in vitro method to predict in vivo photoprotection of skin hyperpigmentation induced by visible light.

J Eur Acad Dermatol Venereol 2022 Jun 14;36(6):922-926. Epub 2022 Mar 14.

Department of Dermatology, Centre Hospitalier Universitaire de Nice, University Côte d'Azur, Nice, France.

Background: Ultraviolet radiation is the main cause of skin pigmentation, but more recently visible light has been shown to be an important contributor especially in melano-competent subjects. Photoprotection from visible light can improve several hyperpigmentation disorders. Recently, a visible light photoprotection assessment method has been proposed based on in vivo pigmentation; the visible light photoprotection factor (VL-PF) is determined by assessment of the change in colorimetry parameter ITA over several days measured using a chromameter. Read More

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Lipid Nanomaterials for Targeted Delivery of Dermocosmetic Ingredients: Advances in Photoprotection and Skin Anti-Aging.

Nanomaterials (Basel) 2022 Jan 24;12(3). Epub 2022 Jan 24.

Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain.

Despite the health benefits of the sun, overexposure to solar radiation without proper precautions can cause irreversible damage to exposed skin. In the search for balance between the risks and benefits of exposure to solar radiation in human health, a technological alternative was found, the incorporation of photoprotective products in lipid nanoparticulate systems for topical application. These nanometric systems have demonstrated several advantages when used as adjuvants in photoprotection compared to chemical and/or physical sunscreens alone. Read More

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January 2022

Slip versus Slop: A Head-to-Head Comparison of UV-Protective Clothing to Sunscreen.

Cancers (Basel) 2022 Jan 21;14(3). Epub 2022 Jan 21.

Department of Dermatology, Oregon Health & Science University, Portland, OR 97239, USA.

Ultraviolet radiation (UVR) exposure is the most important modifiable risk factor for skin cancer development. Although sunscreen and sun-protective clothing are essential tools to minimize UVR exposure, few studies have compared the two modalities head-to-head. This study evaluates the UV-protective capacity of four modern, sun-protective textiles and two broad-spectrum, organic sunscreens ( 30 and 50). Read More

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January 2022

Sunscreens with the New MCE Filter Cover the Whole UV Spectrum: Improved UVA1 Photoprotection In Vitro and in a Randomized Controlled Trial.

JID Innov 2022 Jan 25;2(1):100070. Epub 2021 Nov 25.

L'Oréal Research and Innovation, Aulnay-sous-Bois, France.

Background: UVA1 rays (340-400 nm) contribute to carcinogenesis, immunosuppression, hyperpigmentation, and aging. Current sunscreen formulas lack sufficient absorption in the 370-400 nm wavelengths range. Recently, a new UVA1 filter, Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (MCE) exhibiting a peak of absorption at 385 nm, was approved by the Scientific Committee on Consumer Safety for use in sunscreen products. Read More

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January 2022

Photoprotection for Skin of Color.

Am J Clin Dermatol 2022 Mar 19;23(2):195-205. Epub 2022 Jan 19.

Department of Dermatology, Johns Hopkins University School of Medicine, 601 N Caroline Street, Suite 8060C, Baltimore, MD, 21287, USA.

Photoprotection behaviors can mitigate skin damage caused by ultraviolet radiation, and common methods include seeking shade, avoiding sun exposure during peak daylight hours, wearing sun-protective clothing, applying sunscreen, and using sunglasses. While the role of sun protection in preventing sunburns, photoaging, and skin cancer is well established in fair-skinned populations, individuals with skin of color (SOC) are presumed to suffer fewer negative effects from solar radiation. Thus, the importance of photoprotection in this population is understudied and may be underestimated. Read More

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Sunscreen lotions in the dermatological prescription: review of concepts and controversies.

An Bras Dermatol 2022 Mar-Apr;97(2):204-222. Epub 2022 Jan 14.

Dermatology Department, Faculty of Medicine, Universidade Estadual Paulista, Botucatu, SP, Brazil.

The skin is regularly exposed to several environmental aggressions, including solar radiation, whose biological effects can induce sunburn, dyschromia, skin aging and cancer. Among the photoprotection measures, sunscreens comprise a relevant part of the strategy aimed to prevent solar radiation damage and, for effective action, the patient must adhere to the product use and the latter, in turn, must follow technical parameters to promote adequate protection. This review article brings together the most current and relevant concepts about photoprotection for dermatological use, including the challenges for their formulation, the risks of certain photoprotective active substances for individual and environmental safety and the importance of stringency in determining the product efficacy, considering the regulatory aspects, highlighting relevant differences between Brazil and other countries. Read More

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Vaccinium myrtillus L. extract associated with octocrylene, bisoctrizole, and titanium dioxide: in vitro and in vivo tests to evaluate safety and efficacy.

J Cosmet Dermatol 2022 Jan 13. Epub 2022 Jan 13.

Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

Objective: The harmful effects induced by ultraviolet exposition and the significant increment in skin cancer diagnosis confirm the necessity to develop effective and safe sunscreens. Limited efficacy and cutaneous adverse reactions of traditional formulations drove the incorporation of natural extracts into multifunctional sunscreens. Vaccinium myrtillus L. Read More

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January 2022

Assessment of Solar Filters for Erythropoietic Protoporphyria in the Action Spectrum of Protoporphyrin IX.

Front Med (Lausanne) 2021 20;8:796884. Epub 2021 Dec 20.

Dermatology Unit, Department of Medicine (DIMED), University of Padova, Padua, Italy.

Subjects with erythropoietic protoporphyria rely on broad-spectrum sunscreens with high sun protection factor, which is not informative on efficacy in the absorption spectrum of protoporphyrin IX, spanning visible radiation and peaking around 408 nm. Photoactivation of protoporphyrin IX is responsible for painful skin photosensitivity in erythropoietic protoporphyria. The authors assessed the protective efficacy of six sunscreens in the absorption spectrum of protoporphyrin IX. Read More

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December 2021

Practical guide to tinted sunscreens.

J Am Acad Dermatol 2021 Dec 30. Epub 2021 Dec 30.

Photomedicine and Photobiology Unit, Department of Dermatology, Henry Ford Health System, Detroit, Michigan. Electronic address:

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December 2021

Sunscreen Effect Exerted by Secondary Carotenoids and Mycosporine-like Amino Acids in the Aeroterrestrial Chlorophyte under High Light and UV-A Irradiation.

Plants (Basel) 2021 Nov 26;10(12). Epub 2021 Nov 26.

Department of Bioengineering, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, 119192 Moscow, Russia.

The microalga dwells in habitats with excessive solar irradiation; consequently, it must accumulate diverse compounds to protect itself. We characterized the array of photoprotective compounds in . Toward this goal, we exposed the cells to high fluxes of visible light and UV-A and analyzed the ability of hydrophilic and hydrophobic extracts from the cells to absorb radiation. Read More

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November 2021

A new visible light absorbing organic filter offers superior protection against pigmentation by wavelengths at the UVR-visible boundary region.

J Photochem Photobiol B 2022 Feb 11;227:112372. Epub 2021 Dec 11.

St. John's Institute of Dermatology, King's College London, Guy's Hospital, London SE1 9RT, UK.

Skin pigmentation by solar ultraviolet radiation (UVR; ~295-400 nm) is well established. More recently, visible light (VL; 400-740 nm) has been shown to induce rapid pigmentation. Such pigmentation is thought to be caused by oxidative stress, which has associations with skin cancer and photoageing. Read More

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February 2022

Photo-aging evaluation - In vitro biological endpoints combined with collagen density assessment with multi-photon microscopy.

J Dermatol Sci 2022 Jan 8;105(1):37-44. Epub 2021 Dec 8.

L'Oréal Research and Innovation, Shanghai, PR China. Electronic address:

Background: Ultraviolet exposure has profound effect on the dermal connective tissue of human skin.

Objective: We aimed to develop and validate an evaluation method/methodology using a full-thickness reconstructed skin model, to assess the anti-photoaging efficacy of cosmetic ingredients and sunscreen formulas by blending multi relevant biological endpoints including the newly developed dermal collagen quantification method with Multi-photon microscopy.

Methods: The response of ex vivo human skin to UVA exposure was first characterized with multiphoton microscopy. Read More

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January 2022

Unravelling the Photoprotection Properties of Garden Cress Sprout Extract.

Molecules 2021 Dec 16;26(24). Epub 2021 Dec 16.

Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.

Plants, as with humans, require photoprotection against the potentially damaging effects of overexposure to ultraviolet (UV) radiation. Previously, sinapoyl malate (SM) was identified as the photoprotective agent in thale cress. Here, we seek to identify the photoprotective agent in a similar plant, garden cress, which is currently used in the skincare product Detoxophane nc. Read More

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December 2021

Photoprotection for all: Current gaps and opportunities.

J Am Acad Dermatol 2022 03 20;86(3S):S18-S26. Epub 2021 Dec 20.

Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

The effects of solar radiation on human skin differ based on the skin phototype, presence or absence of photodermatoses, biologic capacity to repair DNA damage, wavelength, intensity of sun exposure, geographic latitude, and other factors, underscoring the need for a more tailored approach to photoprotection. To date, the focus of photoprotection guidelines has been to prevent sunburn and DNA damage induced by UV radiation, both UVB and UVA; however, several recent studies have shown that visible light also generates reactive oxygen and nitrogen species that can contribute to skin damage and pigmentation on the skin, particularly in people with skin of color. Therefore, individuals with dark skin, while naturally better protected against UVB radiation by virtue of the high eumelanin content in melanocytes, may need additional protection from visible light-induced skin damage. Read More

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Photoprotection for skin of all color: Consensus and clinical guidance from an expert panel.

J Am Acad Dermatol 2022 03 20;86(3S):S1-S8. Epub 2021 Dec 20.

Department of Dermatology, Henry Ford Health, Detroit, Michigan.

The negative effects of sun exposure have become better accepted among health care professionals and the lay public over recent decades. Most attention has been focused on the effects of UV light, particularly UVB wavelengths (290-320 nm). Accordingly, products to protect skin from sunlight-associated harm (sunscreens) have been developed to minimize UVB exposure. Read More

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Misconceptions of photoprotection in skin of color.

J Am Acad Dermatol 2022 03 21;86(3S):S9-S17. Epub 2021 Dec 21.

Department of Dermatology, Henry Ford Health, Detroit, Michigan.

Terrestrial sunlight is the portion of electromagnetic radiation that is emitted by the sun and reaches Earth's surface. It encompasses 3 major components: UV radiation (290-400 nm), visible light (400-700 nm), and infrared radiation. The deleterious effects of UV radiation have been appreciated for decades, particularly among those with light skin tones (Fitzpatrick skin types I-II) who primarily manifest with burns of varying degrees of severity with sun exposure. Read More

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-Derived Actinomycetes as Bioresources of Photoprotection-Related Bioactive End-Products.

Mar Drugs 2021 Nov 27;19(12). Epub 2021 Nov 27.

Doctorate in Biosciences, School of Engineering, Universidad de La Sabana, Chía 250001, Colombia.

Sunscreen and sunblock are crucial skincare products to prevent photoaging and photocarcinogenesis through the addition of chemical filters to absorb or block ultraviolet (UV) radiation. However, several sunscreen and sunblock ingredients, mostly UV filters, have been associated with human and environmental safety concerns. Therefore, the exploration and discovery of promising novel sources of efficient and safer compounds with photoprotection-related activities are currently required. Read More

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November 2021

Mechanistic photophysics and photochemistry of unnatural bases and sunscreen molecules: insights from electronic structure calculations.

Phys Chem Chem Phys 2021 Dec 15;23(48):27124-27149. Epub 2021 Dec 15.

Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China.

Photophysics and photochemistry are basic subjects in the study of light-matter interactions and are ubiquitous in diverse fields such as biology, energy, materials, and environment. A full understanding of mechanistic photophysics and photochemistry underpins many recent advances and applications. This contribution first provides a short discussion on the theoretical calculation methods we have used in relevant studies, then we introduce our latest progress on the mechanistic photophysics and photochemistry of two classes of molecular systems, namely unnatural bases and sunscreens. Read More

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December 2021

Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect.

Pharmaceutics 2021 Nov 20;13(11). Epub 2021 Nov 20.

Laboratório Associado para a Química Verde (LAQV), REQUIMTE (Rede de Química e Tecnologia), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

Niacinamide (NIA) has been widely used in halting the features of ageing by acting as an antioxidant and preventing dehydration. NIA's physicochemical properties suggest difficulties in surpassing the barrier imposed by the stratum corneum layer to reach the target in the skin. To improve cutaneous delivery of NIA, a hybrid nanogel was designed using carrageenan and polyvinylpyrrolidone polymers combined with jojoba oil as a permeation enhancer. Read More

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November 2021