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    477 results match your criteria Sunscreens and Photoprotection

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    The photoprotective and anti-inflammatory activity of red propolis extract in rats.
    J Photochem Photobiol B 2018 Jan 31;180:198-207. Epub 2018 Jan 31.
    Universidade Tiradentes, Av. Murilo Dantas, 300, Farolânida, Aracaju, SE, Brazil; Instituto de Tecnologia e Pesquisa - ITP, Av. Murilo Dantas, 300, Farolânida, Aracaju, SE, Brazil.
    The negative effects triggered by ultraviolet radiation, such as premature aging and carcinogenesis, have motivated several studies on photoprotection. Recent strategies for photoprotection have included the incorporation of natural antioxidant and anti-inflammatory compounds, such as flavonoids, into sunscreens and the oral administration of natural antioxidant extracts. Brazilian Red propolis extract contains isoflavonoids with antioxidant and anti-inflammatory activities. Read More

    Role of solid lipid nanoparticles as photoprotective agents in cosmetics.
    J Cosmet Dermatol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Pharmaceutics, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte University, Mangalore, India.
    Background: Novel drug delivery systems have gained popularity since last two decades because of its advantages over conventional dosage forms. Effect of UV radiation on skin can cause either acute or chronic damage to our skin. Solid lipid nanoparticles (SLNs) were developed as novel carrier over the conventional carrier systems like liposomes and emulsions. Read More

    Melanin distribution in human epidermis affords localized protection against DNA photodamage and concurs with skin cancer incidence difference in extreme phototypes.
    FASEB J 2018 Feb 2:fj201701472R. Epub 2018 Feb 2.
    St. John's Institute of Dermatology, King's College London, London, United Kingdom.
    Epidermal DNA damage, especially to the basal layer, is an established cause of keratinocyte cancers (KCs). Large differences in KC incidence (20- to 60-fold) between white and black populations are largely attributable to epidermal melanin photoprotection in the latter. The cyclobutane pyrimidine dimer (CPD) is the most mutagenic DNA photolesion; however, most studies suggest that melanin photoprotection against CPD is modest and cannot explain the considerable skin color-based differences in KC incidence. Read More

    Origins of Photodamage in Pheomelanin Constituents: Photochemistry of 4-Hydroxybenzothiazole.
    J Phys Chem A 2018 Feb 14. Epub 2018 Feb 14.
    Department of Chemistry, Temple University , Philadelphia, Pennsylvania 19122, United States.
    4-Hydroxybenzothiazole (4-HBT) is a molecular constituent of pheomelanin-a polymeric skin centered pigment which acts as a natural photoprotector against harmful solar-UV radiation. Its molecular structure is therefore required to sustain a degree of photostability upon electronic excitation with UV irradiation. Despite its function as a protector against UV, pheomelanin is known to be less photostable than that of its close derivative eumelanin-a dark skin centered pigment. Read More

    Influence of Visible Light on Cutaneous Hyperchromias: Clinical Efficacy of Broad Spectrum Sunscreens.
    Photodermatol Photoimmunol Photomed 2018 Jan 30. Epub 2018 Jan 30.
    Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo.
    Introduction: Cutaneous hyperchromias are disorders of skin pigmentation involving increased melanin production and its irregular accumulation in skin cells. The use of sunscreens is fundamental for the control of hyperchromias by reducing the stimulation of pigmentation, since melanin synthesis is mainly stimulated by solar radiation. Many studies have demonstrated that visible light can induce significant skin damage. Read More

    Cutaneous lupus erythematosus: clinico-pathologic correlation.
    G Ital Dermatol Venereol 2018 Jan 24. Epub 2018 Jan 24.
    Dermatology Unit, "A. Perrino" Hospital, Brindisi, Italy.
    Cutaneous lupus erythematosus (CLE) is a chronic-relapsing disease. It is defined as a LE localized to the skin without any significant systemic symptoms. Its annual incidence is of 4 cases per 100,000 persons with a prevalence of 73 cases per 100,000 persons. Read More

    Photoprotection of ultraviolet-B filters: Updated review of endocrine disrupting properties.
    Steroids 2018 Mar 31;131:46-58. Epub 2018 Jan 31.
    CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal. Electronic address:
    The Ultraviolet (UV) radiation is emitted by the sun and is part of the electromagnetic spectrum. There are three types of UV rays (UV-A, UV-B and UV-C), however only UV-A and UV-B have biologic effects in humans, with UV-B radiation being primarily responsible for these effects. Among the measures of photoprotection advised by the health authorities, the topical application of sunscreens (containing UV-B filters) is the preferred worldwide. Read More

    SPF 100+ sunscreen is more protective against sunburn than SPF 50+ in actual use: Results of a randomized, double-blind, split-face, natural sunlight exposure clinical trial.
    J Am Acad Dermatol 2017 Dec 29. Epub 2017 Dec 29.
    New York University School of Medicine, New York, New York. Electronic address:
    Background: The value of additional photoprotection provided by use of high-sun protection factor (SPF) sunscreens is controversial, and limited clinical evidence exists.

    Objective: To compare the sunburn protection provided by SPF 100+ and SPF 50+ sunscreen in conditions of actual use.

    Methods: A total of 199 healthy men and women (≥18 years) participated in a natural sunlight, single-exposure, split-face, randomized, double-blind study in Vail, Colorado. Read More

    Photoprotection by sunscreen depends on time spent on application.
    Photodermatol Photoimmunol Photomed 2017 Dec 13. Epub 2017 Dec 13.
    Department of Dermatology, Bispbjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
    Background: To be effective, sunscreens must be applied in a sufficient quantity and reapplication is recommended. No previous study has investigated whether time spent on sunscreen application is important for the achieved photoprotection.

    Aim: To determine whether time spent on sunscreen application is related to the amount of sunscreen used during a first and second application. Read More

    Photoprotective potential of metabolites isolated from algae-associated fungi Annulohypoxylon stygium.
    J Photochem Photobiol B 2018 Jan 21;178:316-322. Epub 2017 Nov 21.
    Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto - University of Sao Paulo, Ribeirao Preto, Brazil. Electronic address:
    Natural products, or secondary metabolites, obtained from fungal species associated with marine algae have been widely used in sunscreens due to their antioxidant activity and protective potential against solar radiation. The endophytic fungus isolated from Bostrychia radicans algae collected in the Rio Escuro mangrove, São Paulo State, Brazil, Annulohypoxylon stygium (Xylariaceae family) was studied to evaluate the photoprotective potential of its metabolites. The Annulohypoxylon genus can produce secondary metabolites with interesting cytotoxic, antibacterial and antioxidant properties and was never isolated before from a marine alga or had its metabolites studied for UV protection. Read More

    Molecular photoprotection of human keratinocytes in vitro by the naturally occurring mycosporine-like amino acid (MAA) palythine.
    Br J Dermatol 2017 Nov 13. Epub 2017 Nov 13.
    St John's Institute of Dermatology, Faculty of Life Sciences and Medicine, King's College London, London, UK.
    Background: Solar ultraviolet radiation (UVR) induces molecular and genetic changes in the skin, which result in skin cancer, photoageing and photosensitivity disorders. The use of sunscreens is advocated to prevent such photodamage, however most formulations contain synthetic UVR filters that are non-biodegradable and can damage fragile marine ecosystems. Mycosporine-like amino acids (MAA) are natural UVR-absorbing compounds that have evolved in marine species for protection against chronic UVR exposure in shallow-water habitats. Read More

    Quantifying the visual appearance of sunscreens applied to the skin using indirect computer image colorimetry.
    Photodermatol Photoimmunol Photomed 2017 Oct 28. Epub 2017 Oct 28.
    Department of Dermatology and Skin Science, University of British Columbia & Photomedicine Institute, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
    Background: There is no accepted method to objectively assess the visual appearance of sunscreens on the skin.

    Methods: We present a method for sunscreen application, digital photography, and computer analysis to quantify the appearance of the skin after sunscreen application. Four sunscreen lotions were applied randomly at densities of 0. Read More

    Prospects of topical protection from ultraviolet radiation exposure: a critical review on the juxtaposition of the benefits and risks involved with the use of chemoprotective agents.
    J Dermatolog Treat 2017 Aug 18:1-13. Epub 2017 Aug 18.
    a Division of Pharmaceutical Technology , Defence Research Laboratory , Tezpur , Assam , India.
    Solar ultraviolet (UV) radiation exposure is known to cause inevitable damage to human skin via different mechanisms which include disruption of genetic material and generation of free radicals. In the ever emerging field of photoprotective agents, there have been constant endeavors to uphold the standards for optimum protection from solar UV-induced damages which include alarming conditions ranging from severe keratosis to malignant transformation of skin cells. Out of the various methods available for photoprotection, chemical photoprotective agents are most popular due to its ease of applicability, availability, and efficacy. Read More

    Elucidating nuclear motions in a plant sunscreen during photoisomerization through solvent viscosity effects.
    Phys Chem Chem Phys 2017 Aug;19(31):21127-21131
    Department of Chemistry, University of Warwick, Gibbet Hill, Coventry, CV4 7AL, UK.
    We explore the effects of solvent viscosity on the trans-cis photoisomerization of sinapoyl malate, which is utilized as a sunscreen molecule in plants. Our results demonstrate that viscosity has a significant effect on the timescale for isomerization, providing insight into the nuclear motions involved. The ramifications of these findings are discussed with reference to sinapoyl malate's in vivo photoprotection properties. Read More

    Studies on secondary metabolite profiling, anti-inflammatory potential, in vitro photoprotective and skin-aging related enzyme inhibitory activities of Malaxis acuminata, a threatened orchid of nutraceutical importance.
    J Photochem Photobiol B 2017 Aug 12;173:686-695. Epub 2017 Jul 12.
    Plant Biotechnology Laboratory, Department of Botany, North-Eastern Hill University, Shillong 793022, Meghalaya, India. Electronic address:
    Malaxis acuminata D. Don., a small, terrestrial orchid, is endemic to tropical Himalayas at an altitude of 1200-2000m asl. Read More

    Observing and understanding the ultrafast photochemistry in small molecules: applications to sunscreens.
    Sci Prog 2016 Sep;99(3):282-311
    In this review, we discuss the importance of biological and artificial photoprotection against overexposure to harmful ultraviolet radiation. Transient electronic and transient vibrational absorption spectroscopies are highlighted as important tools in understanding the energy transfer in small molecules, with a focus on the application to commercial sunscreens with representative examples given. Oxybenzone, a common ingredient in commercial sunscreens and sinapoyl malate, a biological sunscreen in plant leaves are presented as case studies. Read More

    Natural Substances for Prevention of Skin Photoaging: Screening Systems in the Development of Sunscreen and Rejuvenation Cosmetics.
    Rejuvenation Res 2017 Aug 28. Epub 2017 Aug 28.
    3 Centre for Innovative Biotechnological Investigations NANOLAB (CIBI-NANOLAB) , Moscow, Russia .
    Solar broadband UV irradiation is commonly regarded as a major causative reason for cutaneous photoaging. The pro-aging molecular pathways and cellular targets affected by UVA+UVB light in human skin have been extensively investigated. Notwithstanding growing knowledge in mechanisms of photoaging, research and development of clinically efficient, nontoxic, and sustainable topical preparations providing full physical, chemical, and biological photoprotection still remain a great challenge for pharmaceutical and cosmetic industries. Read More

    A method to assess the protective efficacy of sunscreens against visible light-induced pigmentation.
    Photodermatol Photoimmunol Photomed 2017 Sep 30;33(5):260-266. Epub 2017 Jun 30.
    Dermatology Department, L'Archet 2 Hospital, Nice, France.
    Background: Until now, photoprotection of human skin has involved the development of sunscreens effective in the ultraviolet (UV) domain. During the last ten years, several studies have shown that besides the well-known damaging effects of UV, visible (400-700 nm) and even infrared light (> 700 nm) can induce damage which contributes to photoaging. Furthermore, many photodermatoses are also known to be triggered by visible light (VL). Read More

    Skin resistance to UVB-induced oxidative stress and hyperpigmentation by the topical use of Lactobacillus helveticus NS8-fermented milk supernatant.
    J Appl Microbiol 2017 Aug;123(2):511-523
    Institute of Ageing Research, School of Medicine, Hangzhou Normal University, Hangzhou, China.
    Aims: In this study, we investigated the preventive properties of the supernatant of Lactobacillus helveticus NS8-fermented milk (NS8-FS) against UV light-induced skin oxidative damage and hyperpigmentation.

    Methods And Results: NS8-FS exhibited significant radical scavenging activity in tests with ABSTand DPPH scavenging methods, and as well strongly inhibited 3-morpholinosydnonimine (Sin-1)-induced ROS generation in HaCat keratinocytes. Unexpectedly, NS8-FS was found to inhibit melanin production in B16F10 melanoma cells and to exhibit inhibitory effects both to the enzymatic activity of tyrosinase (TYR) and the expression of proteins required for melanin synthesis. Read More

    Photoprotection: extending lessons learned from studying natural sunscreens to the design of artificial sunscreen constituents.
    Chem Soc Rev 2017 Jun;46(12):3770-3791
    School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
    Evolution has ensured that plants and animals have developed effective protection mechanisms against the potentially harmful effects of incident ultraviolet radiation (UVR). Tanning is one such mechanism in humans, but tanning only occurs post-exposure to UVR. Hence, there is ever growing use of commercial sunscreens to pre-empt overexposure to UVR. Read More

    Mycosporine-like Amino Acids for Skin Photoprotection.
    Curr Med Chem 2017 May 29. Epub 2017 May 29.
    King's College London - St. John's Institute of Dermatology, Faculty of Life Sciences and Medicine London. United Kingdom.
    Excessive human exposure to solar ultraviolet radiation (UVR) continues to be a major public health concern, with skin cancer rates increasing year on year. The major protective measure is the use of synthetic UVR filters formulated into sunscreens, but there is growing concern that these chemicals cause damage to delicate marine ecosystems. One alternative is the use of biocompatible mycosporine-like amino acids (MAA), which occur naturally and are found predominantly in a wide range of marine species. Read More

    Prevalence of photoprotection and its associated factors in risk group for skin cancer in Teresina, Piauí.
    An Bras Dermatol 2017 Mar-Apr;92(2):206-210
    Faculdade Facid-DeVry - Teresina (PI), Brazil.
    Background:: The incidence of skin cancer has increased worldwide, particularly melanoma rates, which had a mean development of 2.6 % a year in the last 10 years. The agreement on the relation between long-term or chronic exposure to the sun and the emergence of these neoplasias has made several workers who perform activities exposed to solar radiation to form a risk group for the development of skin cancer, community health agents included. Read More

    Ultrafast Transient Absorption Spectroscopy of the Sunscreen Constituent Ethylhexyl Triazone.
    J Phys Chem Lett 2017 May 28;8(10):2113-2118. Epub 2017 Apr 28.
    Department of Chemistry and ‡Centre for Scientific Computing, University of Warwick , Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.
    The ultrafast photoprotection mechanisms in operation in ethylhexyl triazone (EHT, octyl triazone), an approved ultraviolet-B (UV-B) chemical filter for commercial sunscreens, remain elusive, with a notable absence of ultrafast time-resolved measurements. These large organic molecules are of increasing interest as they are suspected to be less likely to penetrate the skin than some of the smaller approved filters, thereby reducing the possible adverse effects from sunscreen products. We apply femtosecond transient absorption spectroscopy with electronic structure calculations to unravel the complete photodeactivation mechanism that EHT undergoes after UV-B irradiation. Read More

    Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage.
    Eur J Pharm Sci 2017 Jun 22;104:52-64. Epub 2017 Mar 22.
    Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address:
    The literature claims that incorporation of antioxidants into sunscreens provides additional skin photoprotection by scavenging free radicals formed due to sun radiation, but there are limited in vivo studies that support this hypothesis. This study aims to examine whether addition of antioxidants to a broad-spectrum sunscreen increases its photoprotective effect in real-use conditions. Sunscreen formulations composed of stable UV filters (Tinosorb® S, Tinosorb® M, Uvinul® APlus, and Uvinul® T150) alone or in combination with antioxidants (Spirulina and dimethylmethoxy chromanol-loaded solid lipid nanoparticles) were developed and their appearance, odor, rheological behavior, Sun Protection Factor (SPF), and UVA protection were analyzed. Read More

    The use of a sunscreen containing DNA-photolyase in the treatment of patients with field cancerization and multiple actinic keratoses: a case-series.
    Dermatol Online J 2017 Jan 15;23(1). Epub 2017 Jan 15.
    Melanoma and Skin Cancer Unit, Department of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago. montsemolgo1@ gmail.com.
    Cutaneous field cancerization (CFC) is associated witha high-risk of developing cutaneous squamous cellcarcinoma (cSCC). It manifests as actinic keratoses(AK) as one of the few macroscopic alterations in CFCpatients. A prospective, single-arm, case-series wasperformed to evaluate the utility of a novel sunscreencontaining DNA-photolyase for treatment of CFCin nine subjects (mean age 70. Read More

    Radical-Scavenging Activity of a Sunscreen Enriched by Antioxidants Providing Protection in the Whole Solar Spectral Range.
    Skin Pharmacol Physiol 2017 21;30(2):81-89. Epub 2017 Mar 21.
    Laboratory of Cosmetic Technology, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Background/aim: The main reason for extrinsic skin aging is the negative action of free radicals. The formation of free radicals in the skin has been associated with ultraviolet (UV) exposure and also to visible (VIS) and near-infrared (NIR) irradiations. The aim of the present study was to evaluate the efficacy of a sunscreen in the whole solar range. Read More

    In vitro skin models for the evaluation of sunscreen-based skin photoprotection: molecular methodologies and opportunities.
    Curr Med Chem 2017 Mar 3. Epub 2017 Mar 3.
    L`Oreal Research and Innovation, 1 avenue Eugène Schueller , Aulnay sous Bois 93600. France.
    Identifying and understanding the biological events that occur following ultraviolet (UV) exposure are mandatory to elucidate the biological and clinical consequences of sun exposure, and to provide efficient and adequate photoprotection strategies. The main UV-induced biological features (markers related to sunburn, cancer, photoaging immunosuppression, pigmentation), characterized in human skin in vivo, could be reproduced in adapted models of reconstructed skin in vitro, attesting their high relevance in the field of photobiology. In turn, 3D skin models were useful to discover precise biological pathways involved in UV response and were predictive of in vivo situation. Read More

    Comparison of ultraviolet A light protection standards in the United States and European Union through in vitro measurements of commercially available sunscreens.
    J Am Acad Dermatol 2017 Jul 24;77(1):42-47. Epub 2017 Feb 24.
    BASF Grenzach GmbH, Grenzach-Wyhlen, Germany.
    Background: The importance of adequate ultraviolet A light (UVA) protection has become apparent in recent years. The United States and Europe have different standards for assessing UVA protection in sunscreen products.

    Objective: We sought to measure the in vitro critical wavelength (CW) and UVA protection factor (PF) of commercially available US sunscreen products and see if they meet standards set by the United States and the European Union. Read More

    "Active" photoprotection: sunscreens with DNA repair enzymes.
    G Ital Dermatol Venereol 2017 Jun 16;152(3):302-307. Epub 2017 Feb 16.
    Department of Dermatology, Federico II University, Naples, Italy.
    Ultraviolet (UV) radiation exerts different harmful effects on human health, being the main etiological agent of certain skin cancers and photoaging. In this context, photoprotection, intended as a set of measures adopted to limit and prevent the effects of UV radiation, plays a critical role in avoiding undesired sunlight outcomes. Traditional sunscreens represent a widely used photoprotective approach, even if they exert a "passive photoprotection" and are not effective once damage to skin cells has been generated after sun exposure. Read More

    Rational Design and Synthesis of Efficient Sunscreens To Boost the Solar Protection Factor.
    Angew Chem Int Ed Engl 2017 Mar 27;56(10):2632-2635. Epub 2017 Jan 27.
    Department of Chemistry, Centro de Investigación en Síntesis Química (CISQ), Universidad de La Rioja, Madre de Dios 53, 26006, Logroño, Spain.
    Skin cancer incidence has been increasing in the last decades, but most of the commercial formulations used as sunscreens are designed to protect only against solar erythema. Many of the active components present in sunscreens show critical weaknesses, such as low stability and toxicity. Thus, the development of more efficient components is an urgent health necessity and an attractive industrial target. Read More

    Current challenges in photoprotection.
    J Am Acad Dermatol 2017 Mar 27;76(3S1):S91-S99. Epub 2016 Dec 27.
    Fundacion del Cancer de Piel, Buenos Aires, Argentina.
    Electromagnetic radiation in the ultraviolet, visible, and infrared ranges all produce biologic effects. Ultraviolet filters are the most well-studied photoprotective measure for the adverse effects of ultraviolet radiation. Because of the reported endocrinologic effects of oxybenzone in animal studies, its effects on coral reefs, and its photocontact allergy potential, its use has been minimized in many countries worldwide. Read More

    Ultraviolet radiation and the skin: Photobiology and sunscreen photoprotection.
    J Am Acad Dermatol 2017 Mar 27;76(3S1):S100-S109. Epub 2016 Dec 27.
    Clinical Skin Research and Development Center, Pierre Fabre Dermo-Cosmétique, Toulouse, France; Department of Dermatology, Toulouse University Hospital, Toulouse, France.
    The efficacy of sunscreens can be measured by different methods, involving in vitro, ex vivo, or in vivo techniques. There is a need for a worldwide standardization of these methods to avoid misunderstanding and confusion among sunscreen users. The clinical benefits of sunscreens have been demonstrated in randomized controlled trials that established the role of sunscreens in the prevention of actinic keratoses, squamous cell carcinomas, nevi, and melanomas. Read More

    Photoprotection in specific populations: Children and people of color.
    J Am Acad Dermatol 2017 Mar 27;76(3S1):S110-S121. Epub 2016 Dec 27.
    Buster Dermatology, Tulsa, Oklahoma; University of Alabama at Birmingham, Birmingham, Alabama.
    Improved education on appropriate photoprotection in children is vital. Photoprotection for these individuals should include seeking shade, the use of physical agents (clothing, hat, sunglasses), and application of sunscreens on exposed areas. Avoidance of the use of tanning beds is an important component of education for teenagers. Read More

    Hydrogen bond dynamics governs the effective photoprotection mechanism of plant phenolic sunscreens.
    Photochem Photobiol Sci 2017 02;16(2):211-219
    Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, 430070, P.R. China.
    Sinapic acid derivatives are important sunscreen species in natural plants, which could provide protection from solar UV radiation. Using a combination of ultrafast excited state dynamics, together with classical molecular dynamics studies, we demonstrate that there is direct coupling of hydrogen bond motion with excited state photoprotection dynamics as part of the basic mechanism in solution. Beyond the intra-molecular degree of freedom, the inter-molecular motions on all timescales are potentially important for the photochemical or photophysical events, ranging from the ultrafast hydrogen bond motion to solvent rearrangements. Read More

    Photophysics of sunscreen molecules in the gas phase: a stepwise approach towards understanding and developing next-generation sunscreens.
    Proc Math Phys Eng Sci 2016 Nov;472(2195):20160677
    Department of Chemistry , University of Warwick , Coventry CV4 7AL , UK.
    The relationship between exposure to ultraviolet (UV) radiation and skin cancer urges the need for extra photoprotection, which is presently provided by widespread commercially available sunscreen lotions. Apart from having a large absorption cross section in the UVA and UVB regions of the electromagnetic spectrum, the chemical absorbers in these photoprotective products should also be able to dissipate the excess energy in a safe way, i.e. Read More

    A Perspective on the Ultrafast Photochemistry of Solution-Phase Sunscreen Molecules.
    J Phys Chem Lett 2016 Nov 7;7(22):4655-4665. Epub 2016 Nov 7.
    Department of Chemistry, University of Warwick , Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.
    Sunscreens are one of the most common ways of providing on-demand additional photoprotection to the skin. Ultrafast transient absorption spectroscopy has recently proven to be an invaluable tool in understanding how the components of commercial sunscreen products display efficient photoprotection. Important examples of how this technique has unravelled the photodynamics of common components are given in this Perspective, and some of the remaining unanswered questions are discussed. Read More

    The Photostabilizing Effect of Grape Seed Extract on Three Common Sunscreen Absorbers.
    Photochem Photobiol 2016 11 30;92(6):870-884. Epub 2016 Nov 30.
    School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.
    The photostabilizing ability of grape seed extract on three common sunscreen absorbers, 2-ethylhexyl-p-methoxycinnamate (EHMC), benzophenone-3 (BP3) and tert-butylmethoxy dibenzoylmethane (BMDBM), was investigated. Samples were exposed to simulated solar radiation and monitored by spectrophotometric and chromatographic methods. The chemical composition of the grape seed extract was determined by GC-MS and HPLC-MS, and the major secondary metabolites were found to be epicatechin and catechin. Read More

    One-Year Review of the SCREEN (Skin Cancer Post-Transplant) Clinic.
    J Cutan Med Surg 2017 Jan/Feb;21(1):80-81. Epub 2016 Sep 24.
    2 Department of Dermatology and Skin Science, University of British Columbia and Division of Dermatology, Department of Medicine, St Paul's Hospital and Providence Health Care, Vancouver, BC, Canada.
    The Skin Cancer Post-Transplant (SCREEN) Clinic is a skin-cancer screening clinic that is fully integrated into the renal transplantation clinic at St Paul's Hospital in Vancouver, British Columbia. The purpose of this review was to determine characteristics of patients most at risk for skin cancer, to specify types and locations of skin cancers diagnosed, and to identify areas for patient and physician education. Transplant patients (91% renal; 5% heart) screened by a dermatologist during a 12-month period were stratified into low-, medium-, and high-risk groups based on detailed history and skin examination. Read More

    Quality by design (QbD), Process Analytical Technology (PAT), and design of experiment applied to the development of multifunctional sunscreens.
    Drug Dev Ind Pharm 2017 Feb 13;43(2):246-256. Epub 2016 Oct 13.
    a Department of Pharmacy, Faculty of Pharmaceutical Sciences , University of São Paulo , São Paulo , Brasil.
    Multifunctional formulations are of great importance to ensure better skin protection from harm caused by ultraviolet radiation (UV). Despite the advantages of Quality by Design and Process Analytical Technology approaches to the development and optimization of new products, we found in the literature only a few studies concerning their applications in cosmetic product industry. Thus, in this research work, we applied the QbD and PAT approaches to the development of multifunctional sunscreens containing bemotrizinol, ethylhexyl triazone, and ferulic acid. Read More

    Use of Agave tequilana-lignin and zinc oxide nanoparticles for skin photoprotection.
    J Photochem Photobiol B 2016 Oct 24;163:156-61. Epub 2016 Aug 24.
    Department of Wood, Cellulose and Paper Research, University of Guadalajara, 45110 Guadalajara, Jal, Mexico. Electronic address:
    The use of sunscreens is essential for preventing skin damage and the potential appearance of skin cancer in humans. Inorganic active components such as zinc oxide (ZnO) have been used commonly in sunscreens due to their ability to block UVA radiation. This ultraviolet (UV) protection might be enhanced to cover the UVB and UVC bands when combined with other components such as titanium dioxide (TiO2). Read More

    A new insight into the photochemistry of avobenzone in gas phase and acetonitrile from ab initio calculations.
    Phys Chem Chem Phys 2016 Aug;18(32):22168-78
    Faculty of Physical Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia.
    Avobenzone (4-tert-butyl-4'-methoxydibenzoylmethane, AB) is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. The photochemistry of AB includes keto-enol tautomerization, cis-trans isomerization, rotation about the single bond and α bond cleavages of carbonyl groups. In this contribution we study chelated and non-chelated enol, rotamers Z and E, and keto tautomers of AB in the ground and excited states in gas phase and acetonitrile by means of a coupled cluster method. Read More

    Photoprotective Potential of Baccharis antioquensis (Asteraceae) as Natural Sunscreen.
    Photochem Photobiol 2016 09 12;92(5):742-52. Epub 2016 Aug 12.
    Research Group on Functional Compounds, Institute of Chemistry, University of Antioquia, Medellín, Colombia.
    In the quest for new natural agents of photoprotection, we evaluated the photoprotective and antioxidant activity of B. antioquensis leaf extracts as well as its phenolic composition. The methanolic extract treated with activated carbon showed the highest absorption coefficients for UVA-UVB radiation, as well as an antioxidant capacity comparable to butylated hydroxy toluene. Read More

    Ultrafast photoprotective properties of the sunscreening agent octocrylene.
    Opt Express 2016 May;24(10):10700-9
    Today octocrylene is one of the most common molecules included in commercially available sunscreens. It provides broadband photoprotection for the skin from incident UV-A and UV-B radiation of the solar spectrum. In order to understand how octocrylene fulfils its role as a sunscreening agent, femtosecond pump-probe transient electronic UV-visible absorption spectroscopy is utilised to investigate the ultrafastnonradiative relaxation mechanism of octocrylene in cyclohexane or methanol after UV-B photoexcitation. Read More

    The photoprotective effects of 2-benzoyl-3-phenylquinoxaline 1,4-dioxide against UVB-induced damage in HaCaT cells.
    Med Oncol 2016 Aug 4;33(8):86. Epub 2016 Jul 4.
    Department of Biology, American University of Beirut, Beirut, Lebanon.
    With the increasing levels of atmospheric ozone depletion, there has been much concern about the causal effects of high levels of ultraviolet radiation reaching the Earth's surface on skin cancer. This has led to growing interest in identifying new active ingredients for use in commercial sunscreens. In our study, the chemical compound 2-benzoyl-3-phenylquinoxaline 1,4-dioxide (BPQ) prepared by the Beirut reaction was tested for its ability to protect a human keratinocyte cell line (HaCaT) against ultraviolet B radiation (280-315 nm). Read More

    Design of novel starch-based Pickering emulsions as platforms for skin photoprotection.
    J Photochem Photobiol B 2016 Sep 16;162:56-64. Epub 2016 Jun 16.
    Research Institute for Medicines and Pharmaceutical Sciences (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Portugal. Electronic address:
    Green coffee oil and modified starch were recently found to have an enhanced protection effect against UV radiation. Therefore, this work aimed to develop an innovative sunscreen formulation based on Pickering emulsions concept, i.e. Read More

    Update on treatment of photodermatosis.
    Dermatol Online J 2016 Feb 17;22(2). Epub 2016 Feb 17.
    First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu.
    Photodermatoses are a group of skin conditions associated with an abnormal reaction to ultraviolet (UV) radiation. There are several of the photosensitive rashes which mainly affect the UV exposed areas of the skin. It can be classified into four groups: immunology mediated photodermatoses, chemical and drug induced photosensitivity, photoaggravated dermatoses, and genetic disorders. Read More

    Repartition of oil miscible and water soluble UV filters in an applied sunscreen film determined by confocal Raman microspectroscopy.
    Photochem Photobiol Sci 2016 Jul;15(7):861-71
    University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Institute of Pharmaceutical Technology, Muttenz/Basel, Switzerland and University of Basel, Department of Pharmaceutical Sciences, Basel, Switzerland.
    Photoprotection provided by topical sunscreens is expressed by the sun protection factor (SPF) which depends primarily on the UV filters contained in the product and the applied sunscreen amount. Recently, the vehicle was shown to significantly impact film thickness distribution of an applied sunscreen and sunscreen efficacy. In the present work, repartition of the UV filters within the sunscreen film upon application is investigated for its role to affect sun protection efficacy. Read More

    Protection against UV-induced toxicity and lack of mutagenicity of Antarctic Sanionia uncinata.
    Toxicology 2017 Feb 24;376:126-136. Epub 2016 May 24.
    Laboratory of Environmental Mutagenesis, Department of Biophysics and Biometry, Roberto Alcantra Gomes Biology Institute, University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    Antarctica moss Sanionia uncinata (Hedw.) Loeske is exposed in situ to damaging levels of ultraviolet (UV) radiation. This moss has the ability to respond to UV radiation exposure producing secondary metabolites such as flavonoids, and has been recommended as a potential source of photoprotective compounds and antioxidants. Read More

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