598 results match your criteria Sunscreens and Photoprotection


Dispelling myths about sunscreen.

J Dermatolog Treat 2020 Jul 7:1-5. Epub 2020 Jul 7.

Department of Dermatology, Veterans Affairs Medical Center, and State University of New, York, New York, NY, USA.

Sunscreens are an important tool used to protect the skin against harmful effects of ultraviolet (UV) radiation. Many different formulations of sunscreen exist today, which can be confusing to the consumer. In this article, we highlight and address many sunscreen myths that exist today including the benefits of higher SPF sunscreen, use of sunscreen in darker skin types, and the effects of sunscreen on vitamin D production. Read More

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http://dx.doi.org/10.1080/09546634.2020.1789047DOI Listing

New insight into the photoinduced wavelength dependent decay mechanisms of the ferulic acid system on the excited states.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 1;240:118565. Epub 2020 Jun 1.

College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China; Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou 310014, PR China. Electronic address:

The ferulic acid (FA) is a kind of phenolic acid widely exists in nature plants. Apart from its medicinal values, the FA is also widely applied in cosmetic industry. Recently, it was found to have potential applications in commercial sunscreens for its strong photostability and photoprotection property from harmful UV rays. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118565DOI Listing

Photoprotection With Mineral-Based Sunscreens.

Dermatol Surg 2020 Jun 9. Epub 2020 Jun 9.

Dermatology on Bloor, Toronto, Ontario, Canada.

Background: Although chemical sunscreens have traditionally been at the forefront of sun protection, safety concerns and increasing awareness of the environmental impact of personal-care products have led to greater interest in the use of mineral blockers as photoprotective agents.

Objective: To examine the safety and efficacy of mineral-based sunscreens to allow patients to make informed choices about ultraviolet (UV) protection.

Materials And Methods: A review of the literature was performed using the PubMed database. Read More

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http://dx.doi.org/10.1097/DSS.0000000000002478DOI Listing

Exploring the Potential Use of Peels as a Source of Cosmeceutical Sunscreen Agent for Its Antioxidant and Photoprotective Properties.

Evid Based Complement Alternat Med 2020 4;2020:7520736. Epub 2020 May 4.

Centre for Drug Research, Universiti Sains Malaysia, 11800 USM, George Town, Penang, Malaysia.

Currently, consumers' demand for sunscreens derived from natural sources that provide photoprotection from ultraviolet (UV) radiation is pushing the cosmetic industry to develop breakthrough formulations of sun protection products by incorporating plant antioxidants as their active ingredients. In this context, the present study was initiated to evaluate the antioxidant and photoprotective properties of the underutilized peel extract (HPPE) using spectrophotometric techniques. The phytochemical screenings of HPPE conducted via high-performance liquid chromatography (HPLC) and ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) revealed the presence of phenolic acids and flavonoids as the major secondary metabolites in HPPE. Read More

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http://dx.doi.org/10.1155/2020/7520736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222543PMC

Photoprotection beyond ultraviolet radiation: A review of tinted sunscreens.

J Am Acad Dermatol 2020 Apr 23. Epub 2020 Apr 23.

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. Electronic address:

Ultraviolet radiation and visible light both have biologic effects on the skin. Visible light can induce erythema in light-skinned individuals and pigmentation in dark-skinned individuals. Broad-spectrum sunscreens protect against ultraviolet radiation but do not adequately protect against visible light. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.079DOI Listing

Fucoxanthin for Topical Administration, a Phototoxic vs. Photoprotective Potential in a Tiered Strategy Assessed by In Vitro Methods.

Antioxidants (Basel) 2020 Apr 17;9(4). Epub 2020 Apr 17.

School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP 14040-903 São Paulo, Brazil.

Fucoxanthin possesses a well-described antioxidant activity that might be useful for human skin photoprotection. However, there is a lack of scientific information regarding its properties when applied onto human skin. Thus, the objective of the present study was to assess the photoprotective and phototoxicity potential of fucoxanthin based on its ultraviolet (UVB 280-320 nm; UVA 320-400 nm) and visible (VIS 400-700 nm) absorption, photostability, phototoxicity in 3T3 mouse fibroblast culture vs. Read More

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http://dx.doi.org/10.3390/antiox9040328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222355PMC

Photoprotection and Skin Pigmentation: Melanin-Related Molecules and Some Other New Agents Obtained from Natural Sources.

Authors:
Francisco Solano

Molecules 2020 Mar 27;25(7). Epub 2020 Mar 27.

Department of Biochemistry and Molecular Biology B and Immunology, School of Medicine and LAIB-IMIB, University of Murcia, 30100 Murcia, Spain.

Direct sun exposure is one of the most aggressive factors for human skin. Sun radiation contains a range of the electromagnetic spectrum including UV light. In addition to the stratospheric ozone layer filtering the most harmful UVC, human skin contains a photoprotective pigment called melanin to protect from UVB, UVA, and blue visible light. Read More

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http://dx.doi.org/10.3390/molecules25071537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180973PMC

Cutaneous Photoprotection: A Review of the Current Status and Evolving Strategies.

Yale J Biol Med 2020 03 27;93(1):55-67. Epub 2020 Mar 27.

Department of Dermatology, Yale School of Medicine, New Haven, CT.

Ultraviolet radiation (UVR) exposure is well established as the major environmental risk factor for the development of melanoma, cutaneous squamous cell carcinoma (cSCC), and basal cell carcinoma (BCC). Additional risk factors including genetic mutations, other environmental agents, and immune status are important in modulating the effects of UVR. Dermatologists advocate a multi-pronged approach to minimizing UVR exposure including lifestyle modifications, UVR protective clothing, and topically applied sun-protective products, sunscreen. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087054PMC

Orally administered mixed carotenoids protect human skin against ultraviolet A-induced skin pigmentation: A double-blind, placebo-controlled, randomized clinical trial.

Photodermatol Photoimmunol Photomed 2020 May 12;36(3):219-225. Epub 2020 Mar 12.

IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.

Background: Photoprotection of human skin is determined as the capacity of sunscreens to prevent ultraviolet (UV) B radiation-induced erythema and UVA radiation-induced pigmentation. It is unequivocal that, in addition to sunscreens, oral supplementation with carotenoids can protect human skin against UVB radiation-induced erythema. It is not known if this is also the case for UVA radiation-induced pigmentation. Read More

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http://dx.doi.org/10.1111/phpp.12541DOI Listing

The Role of Sunscreen in Melasma and Postinflammatory Hyperpigmentation.

Indian J Dermatol 2020 Jan-Feb;65(1):5-10

Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.

Photosensitive conditions such as melasma and postinflammatory hyperpigmentation (PIH) are exacerbated by exposure to ultraviolet (UV) rays and visible light making sunscreen use an essential component of treatment. This is especially true in skin of color patients who are less likely to use photoprotection, even if diagnosed with these photoexacerbated conditions. We aimed to evaluate the body of literature to provide evidence for the use of sunscreen in the treatment of melasma and PIH. Read More

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http://dx.doi.org/10.4103/ijd.IJD_295_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986132PMC
February 2020

Sunscreen products: Rationale for use, formulation development and regulatory considerations.

Saudi Pharm J 2019 Nov 16;27(7):1009-1018. Epub 2019 Aug 16.

Department of Pharmaceutics and Pharmacy Practice, School of Pharmacy, University of Nairobi, P.O Box 19676-00202, Nairobi, Kenya.

The association of sunrays with skin damage have been known since medieval times. The description of the electromagnetic spectrum facilitated the identification of the ultraviolet light spectrum as being responsible for skin damage resulting from prolonged skin exposure. Sunscreens have been used since ancient civilizations with various measures to limit exposure to sun exposure being employed. Read More

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http://dx.doi.org/10.1016/j.jsps.2019.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978633PMC
November 2019

Synergistic effects of binary oil mixtures on the solubility of sunscreen UV absorbers.

Eur J Pharm Sci 2020 Mar 24;145:105230. Epub 2020 Jan 24.

BASF Grenzach GmbH, Koechlinstrasse 1, 79639 Grenzach-Wyhlen, Germany.

Sunscreens for the photoprotection of human skin often are prepared as emulsions, containing organic UV-absorber molecules dissolved in the oil phase. The solubility of such oil-soluble UV-absorbers can be a limiting factor when aiming for high protection against UV-radiation. Possible synergistic effects of combinations of oil components toward UV-absorber solubility are therefore of great interest. Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105230DOI Listing

Quantitative and Qualitative HPLC Analysis of Mycosporine-Like Amino Acids Extracted in Distilled Water for Cosmetical Uses in Four Rhodophyta.

Mar Drugs 2019 Dec 28;18(1). Epub 2019 Dec 28.

Department of Ecology and Geology, Faculty of Sciences, University of Malaga, Institute of Blue Biotechnology and Development (IBYDA), Campus Universitario de Teatinos s/n, E-29071 Malaga, Spain.

Mycosporine-like amino acids (MAAs) have gained considerable attention as highly active photoprotective candidates for human sunscreens. However, more studies are necessary to evaluate the extraction efficiency of these metabolites in solvents compatible with cosmetics and their subsequent analysis by HPLC. In the present study, MAA extraction using distilled water and 20% methanol in four Rhodophyta was investigated. Read More

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http://dx.doi.org/10.3390/md18010027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024326PMC
December 2019

Photoprotection of the future: challenges and opportunities.

J Eur Acad Dermatol Venereol 2020 Mar 3;34(3):447-454. Epub 2020 Jan 3.

Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.

The use of sunscreens is an important and essential component of photoprotection. Since their introduction during the first half of the last century, sunscreens have benefited enormously from major technological advances such as the development of novel UV filters; as a result, their efficacy in preventing UV-induced erythema is unequivocal. More recently, however, new challenges have appeared, which have prompted a robust discussion about the safety of sunscreens. Read More

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http://dx.doi.org/10.1111/jdv.16030DOI Listing

Improving Photoprotection and Implications for 25(OH)D Formation.

Anticancer Res 2020 Jan;40(1):511-518

Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

Background/aim: This review examined the implications of using sunscreen photoprotection on 25(OH)D formation and determined the best photoprotective method to reduce the risk of skin cancer caused by ultraviolet radiation (UVR). Based on previous studies on 25(OH)D formation after use of different amounts of sunscreen and different doses of UVR for approximately one week to different body areas it is possible to estimate the amount of 25(OH)D formed after a week's holiday in Southern and Northern Europe.

Conclusion: The best method of photoprotection by sunscreen is two consecutive applications before sun exposure, ensuring the use of sufficient amounts of sunscreen and minimizing the unprotected skin areas. Read More

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http://dx.doi.org/10.21873/anticanres.13979DOI Listing
January 2020

Oral Polypodium Leucotomos Extract and Its Impact on Visible Light-Induced Pigmentation in Human Subjects

J Drugs Dermatol 2019 Dec;18(12):1198-1203

BACKGROUND: Visible light (VL) has multiple effects on the skin that currently available sunscreens do not protect against. Polypodium leucotomos extract (PLE) has properties that may offer protection against VL. OBJECTIVES: To determine the effectiveness of PLE in preventing VL-induced effects. Read More

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December 2019

Evaluation of the acute toxicity, phototoxicity and embryotoxicity of a residual aqueous fraction from extract of the Antarctic moss Sanionia uncinata.

BMC Pharmacol Toxicol 2019 12 19;20(Suppl 1):77. Epub 2019 Dec 19.

Laboratory of Environmental Mutagenesis, Department of Biophysics and Biometry, University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Background: Ultraviolet (UV) radiation is the main exogenous inductor of skin damage and so photoprotection is important to control skin disorders. The Antarctic moss Sanionia uncinata is an important source of antioxidants and the photoprotective activity of its organic extracts has been investigated. This study aimed to evaluate the potential photoprotection, cytotoxicity and embryotoxicity of residual aqueous fraction (AF) from the moss S. Read More

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http://dx.doi.org/10.1186/s40360-019-0353-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921389PMC
December 2019

Sunscreen: FDA regulation, and environmental and health impact.

Photochem Photobiol Sci 2020 Jan;19(1):66-70

Department of Dermatology, Henry Ford Health System, Detroit, MI 48202, USA.

Photoprotection, including the use of sunscreen, has been shown to decrease the development of keratinocyte cancers and melanoma. Due to concerns about the environmental effects of some organic UVR filters, several locations across the world have begun to pass legislation banning the use of these ingredients in sunscreens. Furthermore, the health effects of several organic UVR filters have also been called into question and a recent proposal by the US FDA has resulted in public confusion about the safety of sunscreens. Read More

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http://dx.doi.org/10.1039/c9pp00366eDOI Listing
January 2020

Synthesis and Characterization of New Multifunctional Self-Boosted Filters for UV Protection: ZnO Complex with Dihydroxyphenyl Benzimidazole Carboxylic Acid.

Molecules 2019 Dec 12;24(24). Epub 2019 Dec 12.

Department of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology (COSMAST), University of Ferrara, Via L. Borsari 46, 44121 Ferrara, Italy.

The incidence of skin cancer is increasing both because of climate change and the increase in pollution than people's incorrect habits of sun exposure. In these regards, sunscreen and photoprotection are essential tools in consenting the benefits induced by safe solar light exposition and skin cancer prevention. In this work, a new class of sunscreen filter was synthesized by chemical combination of a physical filter (ZnO) and Oxisol (dihydroxyphenyl benzimidazole carboxylic acid), an antioxidant molecule with booster effect. Read More

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http://dx.doi.org/10.3390/molecules24244546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943673PMC
December 2019

Unravelling photoprotection in microbial natural products.

Sci Prog 2019 12 30;102(4):287-303. Epub 2019 Sep 30.

Department of Chemistry, University of Warwick, Coventry, UK.

Mycosporine-like amino acids have long been known as a natural form of photoprotection for fungi and cyanobacteria. This review will highlight the key time-resolved experimental and theoretical techniques unravelling their photochemistry and photophysics, and directly link this to their use in commercial skin-care products, namely as sunscreen filters. Three case studies have been selected, each having aided advancement in this burgeoning field of research. Read More

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http://dx.doi.org/10.1177/0036850419877766DOI Listing
December 2019

Prospective Evaluation of the Efficacy of a Food Supplement in Increasing Photoprotection and Improving Selective Markers Related to Skin Photo-Ageing.

Dermatol Ther (Heidelb) 2020 Feb 4;10(1):163-178. Epub 2019 Dec 4.

Dermatology Department, Hospital Universitario Miguel Servet, Saragossa, Spain.

Introduction: Skin exposure to ultraviolet radiation (UVR) can cause oxidative stress, particularly in the absence of adequate protective measures or in individuals with a sensitive skin type. Most commonly, protection from UVR entails the use of topical sunscreens. Sunscreens, however, have various limitations. Read More

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http://dx.doi.org/10.1007/s13555-019-00345-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994571PMC
February 2020

Development and validation of an instrument to assess the knowledge of general practitioners and pediatricians about photoprotection and solar radiation.

An Bras Dermatol 2019 Sep - Oct;94(5):532-541. Epub 2019 Sep 30.

Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros, Montes Claros, MG, Brazil; Department of Pediatrics, Universidade Estadual de Montes Claros, Montes Claros, MG, Brazil.

Background: The knowledge of general practitioners about photoprotection is unknown.

Objectives: To develop and validate an instrument to evaluate the knowledge of general practitioners and pediatricians about photoprotection, gauging the knowledge of these professionals.

Methods: The study followed the steps: (1) Literature identification and item elaboration related to the theme; (2) Content validation; (3) Apparent validation; (4) Construct validation: internal consistency analysis and discriminatory analysis; (5) Reliability analysis. Read More

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http://dx.doi.org/10.1016/j.abd.2019.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857560PMC
December 2019

Molecular modeling as a design tool for sunscreen candidates: a case study of bemotrizinol.

J Mol Model 2019 Nov 26;25(12):362. Epub 2019 Nov 26.

Laboratório de Planejamento Farmacêutico e Simulação Computacional (LaPFarSC), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil.

Sunscreen-based photoprotection is an important strategy to prevent photoaging and skin cancer. Among the effective and modern sunscreens, triazine compounds are known as an important class based on their physical-chemical properties, such as photostability and UV broad-spectrum absorption (UVA and UVB). Molecular modeling and quantum mechanical calculations approaches can be helpful to orientate the design of sunscreens. Read More

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http://dx.doi.org/10.1007/s00894-019-4237-7DOI Listing
November 2019

Bioinspired biomolecules: Mycosporine-like amino acids and scytonemin from Lyngbya sp. with UV-protection potentialities.

J Photochem Photobiol B 2019 Dec 6;201:111684. Epub 2019 Nov 6.

Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Av. General Ramón Corona 2514, Nuevo México, Zapopan C.P. 45138, Jalisco, Mexico. Electronic address:

Since the beginning of life on Earth, cyanobacteria have been exposed to natural ultraviolet-A radiation (UV-A, 315-400 nm) and ultraviolet-B radiation (UV-B, 280-315 nm), affecting their cells' biomolecules. These photoautotrophic organisms have needed to evolve to survive and thus, have developed different mechanisms against ultraviolet radiation. These mechanisms include UVR avoidance, DNA repair, and cell protection by producing photoprotective compounds like Scytonemin, carotenoids, and Mycosporine-like amino acids (MAAs). Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2019.111684DOI Listing
December 2019

Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer.

Bioorg Med Chem Lett 2019 12 28;29(24):126755. Epub 2019 Oct 28.

São Paulo State University (UNESP), School of Pharmaceutical Science, Araraquara 14800-903, Brazil. Electronic address:

The incidence of skin cancers such as non-melanoma skin cancer and malignant melanoma has increased in the last few years mainly because of chronic exposure to ultraviolet (UV) radiation. Sunscreens protect the skin against harmful UV radiations; however, some limitations of these products justify the discovery of new UV filters. Novel 1,3,5-triazine derivatives (12a-h) obtained by the optimization of prototype resveratrol were synthesized and characterized. Read More

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http://dx.doi.org/10.1016/j.bmcl.2019.126755DOI Listing
December 2019

Mycosporine-Like Amino Acids: Making the Foundation for Organic Personalised Sunscreens.

Authors:
Nedeljka N Rosic

Mar Drugs 2019 Nov 12;17(11). Epub 2019 Nov 12.

School of Health and Human Sciences; Southern Cross University, Southern Cross Drive, Bilinga, QLD 4225, Australia.

The surface of the Earth is exposed to harmful ultraviolet radiation (UVR: 280-400 nm). Prolonged skin exposure to UVR results in DNA damage through oxidative stress due to the production of reactive oxygen species (ROS). Mycosporine-like amino acids (MAAs) are UV-absorbing compounds, found in many marine and freshwater organisms that have been of interest in use for skin protection. Read More

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http://dx.doi.org/10.3390/md17110638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891770PMC
November 2019

The Synergistic Behavior of Antioxidant Phenolic Compounds Obtained from Winemaking Waste's Valorization, Increased the Efficacy of a Sunscreen System.

Antioxidants (Basel) 2019 Nov 7;8(11). Epub 2019 Nov 7.

School of Pharmaceutical Sciences, University of São Paulo, São Paulo/SP 05508-900, Brazil.

Grape pomace retains polyphenols in the peels and in the seeds after winemaking, which is indicative of the high valorization potential of this industrial waste. There is strong evidence that phenolics are robust antioxidants and confer photoprotection; thus, it is rational to apply these active compounds from winemaking waste to sunscreens, in order to increase UV protection. Despite the importance of this class of cosmetics to public health, more efficacious strategies are still needed to overcome the problems caused by the photoinstability of some UV filters. Read More

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http://dx.doi.org/10.3390/antiox8110530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912203PMC
November 2019

Guava-fruit extract can improve the UV-protection efficiency of synthetic filters in sun cream formulations.

J Photochem Photobiol B 2019 Dec 19;201:111639. Epub 2019 Oct 19.

Postgraduate Program in Biotechnology, Health Sciences Institute, Federal University of Bahia, Principal Miguel Calmon Avenue, Canela Valley, CEP 40110-100 Salvador, Bahia, Brazil. Electronic address:

Increasing concerns about health safety, social impacts and fair trade have intensified the industrial interest for using natural products in commercial cosmetic formulations. Several studies are currently focusing on plant extracts, but tropical fruits, such as guava, remain yet unexplored and, consequently, underutilized. This research aims to evaluate the potential for using guava-fruit extract as a photoprotective additive agent for sun cream formulations. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2019.111639DOI Listing
December 2019

A novel method for evaluating sun visible light protection factor and pigmentation protection factor of sunscreens.

Clin Cosmet Investig Dermatol 2019 28;12:605-616. Epub 2019 Aug 28.

Department of Photoprotection, Medcin Clinical Research Center, Osasco, Brazil.

Introduction: The role of visible light (VL) in the process of skin pigmentation by solar radiation has been demonstrated. Sunscreens with the presence of pigments, particularly iron oxide (IO), have a greater protective effect against VL and are, therefore, highly recommended for prevention and treatment of hyperpigmentation disorders. This study aimed to evaluate 33 sunscreen formulations, and through spectrophotometric measurements, proposes new methods to evaluate the VL protection factor and the pigmentation protection factor. Read More

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http://dx.doi.org/10.2147/CCID.S207256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718061PMC
August 2019
1 Read

Towards symmetry driven and nature inspired UV filter design.

Nat Commun 2019 10 18;10(1):4748. Epub 2019 Oct 18.

Department of Chemistry, University of Warwick, Gibbet Hill, Coventry, CV4 7AL, UK.

In plants, sinapate esters offer crucial protection from the deleterious effects of ultraviolet radiation exposure. These esters are a promising foundation for designing UV filters, particularly for the UVA region (400 - 315 nm), where adequate photoprotection is currently lacking. Whilst sinapate esters are highly photostable due to a cis-trans (and vice versa) photoisomerization, the cis-isomer can display increased genotoxicity; an alarming concern for current cinnamate ester-based human sunscreens. Read More

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http://dx.doi.org/10.1038/s41467-019-12719-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802189PMC
October 2019

Photoprotection? Gaps in the Final FDA Sunscreen Monograph: The US Sunscreen Dilemma.

Authors:
Howard Epstein

Skinmed 2019;17(4):276. Epub 2019 Jul 1.

EMD Performance Materials, Philadelphia, PA.

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Role of community pharmacists in skin cancer screening: A descriptive study of skin cancer risk factors prevalence and photoprotection habits in Barcelona, Catalonia, Spain.

Pharm Pract (Granada) 2019 Jul-Sep;17(3):1455. Epub 2019 Aug 29.

Dermatologist. Melanoma Unit, Dermatology Department, Hospital Clínic de Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS).Centro de Investigación Biomédica en Red (CIBER), Instituto Carlos III, Barcelona (Spain).

Background: Skin cancer incidence is increasing alarmingly, despite current efforts trying to improve its early detection. Community pharmacists have proven success in implementing screening protocols for a number of diseases because of their skills and easy access.

Objective: To evaluate the prevalence of skin cancer risk factors and the photoprotection habits with a questionnaire in community pharmacy users. Read More

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http://dx.doi.org/10.18549/PharmPract.2019.3.1455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763307PMC
August 2019
1 Read

Anti-aging and Sunscreens: Paradigm Shift in Cosmetics.

Adv Pharm Bull 2019 Aug 1;9(3):348-359. Epub 2019 Aug 1.

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576 104, India.

Skin, being one of the vital organs and a protective barrier needs to be pampered and taken care of from early childhood. It is the most visible and the widest exposed organ and by far reflects the general health condition and the aging process in humans. Both intrinsic and extrinsic factors contribute to this complex biological process of skin aging. Read More

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http://dx.doi.org/10.15171/apb.2019.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773941PMC

Review of the safety of octocrylene used as an ultraviolet filter in cosmetics.

J Eur Acad Dermatol Venereol 2019 Nov;33 Suppl 7:25-33

Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy.

Octocrylene or octocrilene is an organic ultraviolet (UV) filter which absorbs mainly UVB radiation and short UVA wavelengths. It is used in various cosmetic products to either provide an appropriate sun protection factor in sunscreen products or to protect cosmetic formulations from UV radiation. There is no discussion that UV filters are beneficial ingredients in cosmetics since they protect from skin cancer, but octocrylene has been recently incriminated to potentially induce adverse effects on the endocrine system in addition to having allergic and/or photoallergic potential. Read More

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http://dx.doi.org/10.1111/jdv.15945DOI Listing
November 2019

Acetyl zingerone: An efficacious multifunctional ingredient for continued protection against ongoing DNA damage in melanocytes after sun exposure ends.

Int J Cosmet Sci 2020 Feb 17;42(1):36-45. Epub 2019 Dec 17.

Department of Therapeutic Radiology, School of Medicine, Yale University, New Haven, CT, 06520, USA.

Objective: Recent research has shown that significant levels of cyclobutane pyrimidine dimers (CPDs) in DNA continue to form in melanocytes for several hours in the dark after exposure to ultraviolet radiation (UVR) ends. We document the utility of a new multifunctional ingredient, 3-(4-hydroxy, 3-methoxybenzyl)-pentane-2,4-dione (INCI acetyl zingerone (AZ)), to protect melanocytes against CPD formation after UVR exposure ends.

Methods: The use of AZ as an intervention to reduce CPD formation after irradiation was assessed in vitro by comparing kinetic profiles of CPD formation for several hours after irradiation in cells that were untreated or treated with AZ immediately after irradiation. Read More

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http://dx.doi.org/10.1111/ics.12582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004018PMC
February 2020
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Characterization of a nontoxic pyomelanin pigment produced by the yeast Yarrowia lipolytica.

Biotechnol Prog 2020 Mar 4;36(2):e2912. Epub 2019 Nov 4.

Microbial Processes and Interactions, TERRA Teaching and Research Centre, University of Liège - Gembloux Agro Bio Tech, Gembloux, Belgium.

In this study, we report on the ability of the yeast Yarrowia lipolytica W29 to produce an extracellular melanin-like brown pigment at high yield (0.5 mg/ml) in culture medium supplemented with L-tyrosine. This pigment has been characterized as pyomelanin and its synthesis was found to occur by the so-called HGA-melanin pathway. Read More

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http://dx.doi.org/10.1002/btpr.2912DOI Listing
March 2020
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Starch microsponges for enhanced retention and efficacy of topical sunscreen.

Mater Sci Eng C Mater Biol Appl 2019 Nov 12;104:109882. Epub 2019 Jun 12.

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga (E), Mumbai 400019, Maharashtra, India. Electronic address:

Topical sunscreen products are universally applied by numerous individuals to protect their skin from the detrimental effects of UV radiation. However, lately, studies have revealed the risks associated with percutaneous absorption of UV filters leading to undesirable systemic side effects such as hormonal disturbances and allergies. In this study, an innovative sunscreen formulation was developed based on starch microsponges as a key carrier encapsulating an organic sunscreen benzophenone‑3. Read More

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http://dx.doi.org/10.1016/j.msec.2019.109882DOI Listing
November 2019

Use of lip photoprotection in patients suffering from actinic cheilitis.

Eur J Dermatol 2019 Aug;29(4):383-386

Department of Dermatology, University of Santiago de Compostela, Spain.

Background: Actinic cheilitis (AC) is a chronic condition that affects mainly the lower lip.

Objectives: To investigate the use of lip photoprotection in patients with AC.

Materials And Methods: A cross-sectional multicentre study of patients, ≥45 years of age, was performed in eight dermatology departments in the Galicia region over a period of one year. Read More

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http://dx.doi.org/10.1684/ejd.2019.3604DOI Listing
August 2019
1 Read

Long-wavelength Ultraviolet A1 and Visible Light Photoprotection: A Multimodality Assessment of Dose and Response.

Photochem Photobiol 2020 01 30;96(1):208-214. Epub 2019 Sep 30.

Department of Dermatology, Henry Ford Hospital, Detroit, MI.

Human skin is exposed to visible light (VL; 400-700 nm) and long-wavelength ultraviolet A1 (UVA1) radiation (370-400 nm) after the application of organic broad-spectrum sunscreens. The biologic effects of these wavelengths have been demonstrated; however, a dose-response has not been investigated. Ten subjects with Fitzpatrick skin phototype IV-VI were enrolled. Read More

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http://dx.doi.org/10.1111/php.13157DOI Listing
January 2020
8 Reads

Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters.

Int J Pharm 2019 Oct 19;570:118633. Epub 2019 Aug 19.

School of Pharmaceutical Sciences, University of Geneva & University of Lausanne, Switzerland. Electronic address:

Avobenzone (AVO), oxybenzone (OXY), and octyl methoxycinnamate (OMC), are widely used UV filters. The aim of this study was to investigate the effect of incorporation in mesoporous silica (SBA-15) on their cutaneous deposition and permeation. Stick formulations containing "free" and "incorporated" UV filters (SF1 and SF2, respectively) were prepared and characterized with respect to their physicochemical, thermal, and functional properties. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.118633DOI Listing
October 2019

Substitution Dependent Ultrafast Ultraviolet Energy Dissipation Mechanisms of Plant Sunscreens.

J Phys Chem Lett 2019 Sep 26;10(17):5244-5249. Epub 2019 Aug 26.

State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning 116023, China.

An ultraviolet energy dissipation mechanism plays a critical role in the photoprotection effect of sunscreens. In this work, we discovered substitution dependent UV energy dissipation mechanisms of model plant sunscreen methyl sinapate (MS). We found that the initially populated V(ππ*) states of MS and -OMeMS relax to the ground state nonradiatively along an ultrafast trans-cis photoisomerization in tens of picoseconds. Read More

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http://dx.doi.org/10.1021/acs.jpclett.9b02175DOI Listing
September 2019
2 Reads

Saccharomyces cerevisiae strains as bioindicators for titanium dioxide sunscreen photoprotective and photomutagenic assessment.

J Photochem Photobiol B 2019 Sep 8;198:111584. Epub 2019 Aug 8.

Laboratório de Microbiologia e Avaliação Genotóxica (LAMIAG), Faculdade de Farmácia, CCS, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949-900, Brazil. Electronic address:

Although several short-term assays are available for cosmetic photosafety assessment, cell models are usually highly sensitive to UV radiation, tending to overestimate both phototoxic and photomutagenic risks. In addition, these assays are performed with UV doses/fluences that do not correspond to actual environmental conditions. In this sense, Saccharomyces cerevisiae has already proved to be an interesting tool to predict photomutagenic potential of several compounds, including sunscreens. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2019.111584DOI Listing
September 2019
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Higher vitamin D levels in Nigerian albinos compared with pigmented controls.

Int J Dermatol 2019 Oct 16;58(10):1148-1152. Epub 2019 Aug 16.

Department of Medicine, University College Hospital, Ibadan, Oyo State, Nigeria.

Background: Several studies have suggested that the lower vitamin D levels in blacks is attributable to the effect of increased pigmentation in blocking cutaneous ultraviolet (UV)-mediated production of vitamin D. Albinos are devoid of melanin and should invariably have higher vitamin D levels when compared with their pigmented counterparts. However, strict photoprotection required in their medical management has been shown to reduce UV-dependent vitamin D production. Read More

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http://dx.doi.org/10.1111/ijd.14611DOI Listing
October 2019
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Linear and exponential sunscreen behaviours as an explanation for observed discrepancies in sun protection factor testing.

Photodermatol Photoimmunol Photomed 2019 Aug 3. Epub 2019 Aug 3.

Phi consulting, Bordeaux, France.

Background: In vivo testing of sun protection factor (SPF) values can show considerable interlaboratory variability. We studied the underlying reasons and clinical implications.

Methods: Following the ISO 24444:2010 SPF testing method, seven contract research organizations (CROs) tested eight sunscreens marketed as SPF50 or SPF50+ and the reference SPF15 sunscreens P2 and P3 and SPF43 P6. Read More

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http://dx.doi.org/10.1111/phpp.12500DOI Listing
August 2019
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Sunscreen-induced expression and identification of photosensitive marker proteins in human keratinocytes under UV radiation.

Toxicol Ind Health 2019 Jul;35(7):457-465

4 Department of Zoology, Faculty of Science, Shia P.G. College, Lucknow, Uttar Pradesh, India.

Solar ultraviolet (UV) radiation is the main factor of photocarcinogenesis, photoaging, and photosensitivity; thus protection from biological damaging UV radiation is a concern. Sunscreens containing UV filters are the most preferred means of photoprotection but the safety and efficacy of UV filters are in question. Benzophenone (BP) and its derivatives, namely, benzophenone 1 (BP1), is commonly used in sunscreens as a UV blocker. Read More

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http://dx.doi.org/10.1177/0748233719862128DOI Listing
July 2019
3 Reads
1.710 Impact Factor

Outdoor testing of the photoprotection provided by a new water-based broad-spectrum SPF50+ sunscreen product: two double-blind, split-face, randomized controlled studies in healthy adults.

Clin Cosmet Investig Dermatol 2019 27;12:461-467. Epub 2019 Jun 27.

Innovation and Development, ISDIN, Barcelona, Spain.

Purpose: Users often under-apply sunscreens, and one of the main reasons cited for this is the cosmetic formulation of the product. To address this, we developed a water-based sunscreen. The product underwent standard laboratory testing (ISO 24444: 2010) and was determined as sun protection factor (SPF) 50+. Read More

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http://dx.doi.org/10.2147/CCID.S211335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604753PMC
June 2019
6 Reads

Recommendations for photoprotection in pediatric rheumatology patients.

Curr Opin Pediatr 2019 08;31(4):491-497

Department of Pediatrics, University of Toronto.

Purpose Of Review: Patients seen at pediatric rheumatology are at increased risk of immediate and long-term consequences from sun exposure. The objective of this review is to build awareness of the need of sun protection in pediatric rheumatology patients.

Recent Findings: Sun exposure can lead to disease exacerbations in many rheumatic diseases. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000798DOI Listing

New Insight into the Photoprotection Mechanism of Plant Sunscreens: Adiabatic Relaxation Competing with Nonadiabatic Relaxation in the → Photoisomerization of Methyl Sinapate.

J Phys Chem Lett 2019 Aug 15;10(15):4197-4202. Epub 2019 Jul 15.

State Key Laboratory of Molecular Reaction Dynamics , Dalian Institute of Chemical Physics (DICP) , Chinese Academy of Sciences, 457 Zhongshan Road , Dalian , Liaoning 116023 , China.

A great deal of thermally instable form photoisomerization products will be formed from the thermally stable form of the plant sunscreens sinapate esters upon ultraviolet radiation. To reveal the photoisomerization mechanism of the -isomer, we explore the photodynamics of a model plant sunscreen methyl sinapate (MS) in the form in organic solution. The high photoisomerization quantum yield of the -isomer results in the relatively higher photostability of -MS. Read More

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http://dx.doi.org/10.1021/acs.jpclett.9b01651DOI Listing
August 2019
4 Reads

Understanding Ultraviolet Radiation Dorsal Foot Injury at the Beach.

J Am Podiatr Med Assoc 2019 May;109(3):215-225

Background: Efforts made to protect the dorsal aspect of the foot are currently unknown. We sought to determine whether beachgoers protect the dorsal aspect of their feet as frequently as other anatomic sites.

Methods: A convenience sample of Galveston, Texas, beachgoers completed anonymous surveys to assess whether the dorsal foot was at risk for ultraviolet radiation (UV-R) injury. Read More

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http://dx.doi.org/10.7547/16-166DOI Listing
May 2019
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Discovery of Novel UV-Filters with Favorable Safety Profiles in the 5-Arylideneimidazolidine-2,4-dione Derivatives Group.

Molecules 2019 Jun 24;24(12). Epub 2019 Jun 24.

Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.

Effective protection from the harmful effects of UV radiation may be achieved by using sunscreens containing organic or inorganic UV filters. The number of currently available UV filters is limited and some of the allowed molecules possess limitations such as systemic absorption, endocrine disruption properties, contact and photocontact allergy induction, and low photostability. In the search for new organic UV filters we designed and synthesized a series consisting of 5-benzylidene and 5-(3-phenylprop-2-en-1-ylidene)imidazolidine-2,4-dione (hydantoin) derivatives. Read More

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http://dx.doi.org/10.3390/molecules24122321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630718PMC
June 2019
9 Reads