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    Marine and Other Aquatic Dermatoses.
    Indian J Dermatol 2017 Jan-Feb;62(1):66-78
    Diving School, Naval Base, Kochi, Kerala, India.
    Occupational and recreational aquatic activity predisposes our population to a wide variety of dermatoses. Sunburn, urticaria, jellyfish stings, and contact dermatitis to rubber equipment are common allergies that are encountered in the aquatic environment. Among the infections, tinea versicolor, intertrigo, and verruca vulgaris are widespread. Read More

    High Altitude Dermatology.
    Indian J Dermatol 2017 Jan-Feb;62(1):59-65
    Department of Dermatology, Military Hospital, Ahmedabad, Gujarat, India.
    Approximately, 140 million people worldwide live permanently at high altitudes (HAs) and approximately another 40 million people travel to HA area (HAA) every year for reasons of occupation, sports or recreation. In India, whole of Ladakh region, part of Northwest Kashmir, Northern part of Sikkim and Tenga valley of Arunachal are considered inhabited areas of HAA. The low quantity of oxygen, high exposure of ultraviolet (UV) light, very low humidity, extreme subzero temperature in winter, high wind velocity, make this region difficult for lowlanders as well as for tourists. Read More

    Pigmentation traits, sun exposure, and risk of incident vitiligo in women.
    J Invest Dermatol 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA; Department of Epidemiology, Brown University School of Public Health, Providence, RI 02903, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. Electronic address:
    Vitiligo is the most common cutaneous depigmentation disorder worldwide, yet little is known about specific risk factors for disease development. Utilizing data from the Nurses' Health Study (NHS), a prospective cohort study of 51,337 white women, we examined the associations between (1) pigmentary traits and (2) reactions to sun exposure and risk of incident vitiligo. NHS participants responded to a question about clinician-diagnosed vitiligo and year of diagnosis (2001 or before, 2002-2005, 2006-2009, 2010-2011, or 2012+). Read More

    Protective Role of Mitochondrial Peroxiredoxin III against UVB-Induced Apoptosis of Epidermal Keratinocytes.
    J Invest Dermatol 2017 Feb 12. Epub 2017 Feb 12.
    Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea; College of Pharmacy, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea. Electronic address:
    Ultraviolet B (UVB) light induces generation of reactive oxygen species (ROS), ultimately leading to skin cell damage. Mitochondria are a major source of ROS in UVB-irradiated skin cells, with increased levels of mitochondrial ROS having been implicated in keratinocyte apoptosis. Peroxiredoxin III (PrxIII) is the most abundant and potent H2O2-removing enzyme in the mitochondria of most cell types. Read More

    Travelling abroad with cystic fibrosis: Assessment of risks and healthcare requirements.
    Respir Med 2017 Jan 24. Epub 2017 Jan 24.
    Adult Cystic Fibrosis Centre, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK. Electronic address:
    There is limited information on the risks and healthcare requirements of patients with cystic fibrosis (CF) undertaking travel abroad. Of 100 patients (mean age 24.7 years, mean FEV1 57. Read More

    Protective effects of Polypodium leucotomos extract against UVB-induced damage in a model of reconstructed human epidermis.
    Photodermatol Photoimmunol Photomed 2017 Jan 31. Epub 2017 Jan 31.
    Medical Direction Difa Cooper, Caronno Pertusella, Italy.
    Background: Polypodium leucotomos (PL) exerts potent antioxidant, photo-protective, and immune-modulatory activities. A reconstructed human epidermis (RHE) (Episkin) is a suitable model for the evaluation of acute UV-induced cell damage. No data regarding the photo-protective action of PL in this model are available. Read More

    Vitamin D status and risk for malignant cutaneous melanoma: recent advances.
    Eur J Cancer Prev 2017 Jan 25. Epub 2017 Jan 25.
    aInstitute of Food Sciences, National Research Council (CNR), Avellino bDepartment of Surgical, Microsurgical and Medical Sciences, University of Sassari cInstitute of Biomolecular Chemistry, National Research Council (CNR), Cancer Genetics Unit, Sassari dRomagna Scientific Institute for the Study and Cure of Tumors, Skin Cancer Unit, Meldola, Italy.
    Cutaneous malignant melanoma, whose incidence is increasing steadily worldwide, is the result of complex interactions between individual genetic factors and environmental risk factors. Ultraviolet radiation represents the most important environmental risk factor for the development of skin cancers, including melanoma. Sun exposure and early sunburn during childhood are the principal causes of cutaneous melanoma insurgence in adults, with double the risk relative to a nonexposed population. Read More

    Sun Protection by Beach Umbrella vs Sunscreen With a High Sun Protection Factor: A Randomized Clinical Trial.
    JAMA Dermatol 2017 Jan 18. Epub 2017 Jan 18.
    Department of Dermatology, New York University School of Medicine, New York.
    Importance: Sun-protective behavior affects skin cancer prevention. Shade works by physically shielding skin from direct harmful UV rays; however, skin may still remain exposed to reflected and indirect UV rays. There is no current standard metric to evaluate shade for its effectiveness in sun protection, and there is insufficient clinical evidence that a beach umbrella alone can provide adequate sun protection. Read More

    Tanning equipment use: 2014 Canadian Community Health Survey.
    Health Rep 2017 Jan;28(1):12-16
    Environmental Health Science and Research Bureau, Population Studies Division, Health Canada, Ottawa, Ontario.
    Background: Tanning equipment use is related to the early onset of cancer, with the risk increasing as the duration and repetition of exposure increase. In 2009, the International Agency for Research on Cancer classified tanning equipment use as carcinogenic to humans, and according to the World Health Organization, the risk of skin melanoma increases significantly when use begins before age 35.

    Data And Methods: The rapid response component of the 2014 Canadian Community Health Survey collected data on the use of tanning equipment in the previous 12 months, including reasons for use, frequency/duration of use, precautions taken, and adverse reactions or injuries. Read More

    Detailed Audiological Evaluation of a Patient with Xeroderma Pigmentosum with Neural Degeneration.
    J Am Acad Audiol 2017 Jan;28(1):80-90
    Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA.
    Background: Xeroderma pigmentosum (XP) is a rare autosomal recessive condition characterized by extreme sensitivity to ultraviolet light. Individuals with XP lack the ability to repair DNA (deoxyribonucleic acid) damage caused by ultraviolet radiation, leading to sunburn and increased susceptibility to skin cancers. Approximately 25% of patients also exhibit neural degeneration, which includes progressive mental deterioration, cortical thinning, and sensorineural hearing loss. Read More

    Melanoma awareness and prevalence of dermoscopic examination among internet users: a cross-sectional survey.
    Postepy Dermatol Alergol 2016 Dec 2;33(6):421-428. Epub 2016 Dec 2.
    Department of Epidemiology, Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology Gliwice Branch, Gliwice, Poland.
    Introduction: Melanoma presents the greater threat to health the later the disease is detected and treated, although treatment results can be improved by the widespread use of dermoscopy. However, scarce data are available concerning the awareness of dermoscopy and the frequency of its performance in the non-patient population.

    Aim: To assess the awareness of melanoma detection by dermoscopic examination among the audience of a scientific website. Read More

    [Secrets of the red-headed].
    Pol Merkur Lekarski 2016 Dec;41(246):306-309
    Medical University of Wrocław Poland: Students of Medical Faculty.
    : Only 1-2% of people is red-headed but in the Russian Udmurt Republic or United Kingdom they can be met more often. A specific variant of MC1R gene (R allele) is responsible for the red hair. The gene encodes a receptor for melanocortins. Read More

    Georgian Med News 2016 Nov(Issue):95-100
    National University of Pharmacy, Kharkiv; Kharkiv National Medical University; State institution "State Expert Center MoH Ukraine", Kiev, Ukraine.
    The purpose of this study was to assess the impact of ultraviolet irradiation (UV) on morphological and functional condition of the skin in guinea pigs. The study involved 30 albino guinea pigs weighing 400-500 g subjected to local exposure to UV irradiation. Control group consisted of intact guinea pigs. Read More

    Identifying people at higher risk of melanoma across the U.K.: a primary-care-based electronic survey.
    Br J Dermatol 2016 Dec 23. Epub 2016 Dec 23.
    Primary Care Unit, Department of Public Health & Primary Care, University of Cambridge School of Clinical Medicine, Strangeways Research Laboratory, Cambridge, CB1 8RN, U.K.
    Background: Melanoma incidence is rising rapidly worldwide among white populations. Defining higher-risk populations using risk prediction models may help targeted screening and early detection approaches.

    Objectives: To assess the feasibility of identifying people at higher risk of melanoma using the Williams self-assessed clinical risk estimation model in U. Read More

    Correlates of sun protection behaviors among Hispanic children residing in a high UVR environment.
    Photodermatol Photoimmunol Photomed 2016 Dec 20. Epub 2016 Dec 20.
    Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
    Background/purpose: Rates of melanoma are rising in Hispanics in the United States. Excessive sun exposure in childhood increases the risk of melanoma in adulthood, and little is known about the factors motivating sun protection behaviors among Hispanic youth.

    Methods: Correlates of sun protection were examined among Hispanic children residing in Los Angeles, California (N = 1891). Read More

    Expansion of the genotypic and phenotypic spectrum of xeroderma pigmentosum in Chinese population.
    Photodermatol Photoimmunol Photomed 2017 Jan;33(1):58-63
    Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
    Background: Xeroderma pigmentosum (XP) is a rare genodermatosis characterized by exaggerated sunburn reactions, freckle-like pigmentation, and a high possibility of developing cutaneous tumors. XP comprised seven complementation groups (from XP-A to XP-G) and a variant form XP-V.

    Methods: This study was based on five unrelated Chinese families with six patients clinically suspected to be XP. Read More

    Factors associated with regular sunscreen use by medical students of a Peruvian university.
    J Prev Med Hyg 2016 Sep;57(3):E172-E177
    CRONICAS Center of Excellence for Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
    Introduction: Use of sunscreen is encouraged to reduce the risk of skin pathologies caused by radiation. It is important to acknowledge the associated factors that promote or hinder sunscreen use in young populations as to design better prevention policies.

    Objective: To determine the factors associated with regular sunscreen use among first year medical students from a Peruvian university. Read More

    Impact of Cluster Zone Leaf Removal on Grapes cv. Regent Polyphenol Content by the UPLC-PDA/MS Method.
    Molecules 2016 Dec 11;21(12). Epub 2016 Dec 11.
    Department of Fruit and Vegetable Processing, Wroclaw University of Environmental and Life Sciences, Chełmońskiego 37 Street, 51-630 Wrocław, Poland.
    Leaf removal is known to enhance light exposure of clusters and therefore may affect grape composition. Owing to the risk of decreasing grape quality or sunburn as a consequence of improper sun exposure, it is crucial to determine the optimum leaf removal techniques adequate for the particular climate conditions of a vineyard area. Defoliation experiments on vine cv. Read More

    The risks and benefits of sun exposure 2016.
    Dermatoendocrinol 2016 Jan-Dec;8(1):e1248325. Epub 2016 Oct 19.
    Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University Medical Center , Boston, MA, USA.
    Public health authorities in the United States are recommending that men, women and children reduce their exposure to sunlight, based on concerns that this exposure will promote skin cancer. On the other hand, data show that increasing numbers of Americans suffer from vitamin D deficiencies and serious health problems caused by insufficient sun exposure. The body of science concerning the benefits of moderate sun exposure is growing rapidly, and is causing a different perception of sun/UV as it relates to human health. Read More

    Translation and adaptation of skin cancer genomic risk education materials for implementation in primary care.
    J Community Genet 2017 Jan 6;8(1):53-63. Epub 2016 Dec 6.
    Memorial Sloan Kettering Cancer Center, 641 Lexington Ave. 7th Floor, New York, NY, 10022, USA.
    Genomic medicine has revolutionized disease risk identification and subsequent risk reduction interventions. Skin cancer risk genomic feedback is a promising vehicle to raise awareness and protective behaviors in the general population, including Hispanics who are largely unaware of their risks. Yet, personalized genomics currently has limited reach. Read More

    Number and size of acquired melanocytic nevi and affecting risk factors in cases admitted to the dermatology clinic.
    Postepy Dermatol Alergol 2016 Oct 21;33(5):375-380. Epub 2016 Oct 21.
    Dermatology Clinic, School of Medicine, Balıkesir University, Balıkesir, Turkey.
    Introduction: The size and number of acquired melanocytic nevi (AMN) and presence of dysplastic nevi are the leading risk factors that should be recognized in the development of malignant melanoma.

    Aim: To evaluate AMN and risk factors in the development of AMN in all age groups admitted to a dermatology outpatient clinic.

    Material And Methods: Four hundred and twelve patients who were admitted to the dermatology outpatient clinic for any dermatological symptom and who accepted to participate in the study were randomly included in the study. Read More

    Lgr6+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors.
    Oncotarget 2016 Dec;7(52):86740-86754
    Department of Dermatology, LUMC, Leiden, The Netherlands.
    Lgr6+ cells have been identified as a novel class of proliferating (Ki67+) stem cells in mouse epidermis. We investigated their response to UV exposure in Lgr6-EGFP-Ires-CreERT2/R26R-LacZ haired and hairless mice and whether they become initiating cells of UV- or chemically induced skin tumors. UV overexposure erased Lgr6+ cells (EGFP+) from the interfollicular epidermis (IFE), but - as after wounding - they apparently repopulated the IFE from the hair follicles. Read More

    Sun protective behaviour and sunburn prevalence in primary and secondary schoolchildren in western Switzerland.
    Swiss Med Wkly 2016 12;146:w14370. Epub 2016 Nov 12.
    Division of Chronic Diseases, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Switzerland.
    Aims Of The Study: Although solar overexposure during childhood and adolescence increases the risk of melanoma, determinants of sunburn and sun protective behaviours of Swiss children have scarcely been explored. We investigated sunburn occurrence and sun protective behaviours of schoolchildren in western Switzerland, the region with the highest incidence of melanoma in Europe.

    Material And Methods: Self-reported questionnaires were administered during regular classes to pupils in 5th (primary school, n = 431), 8th and 11th grades (secondary school, n = 837) in the 18 public schools of La Chaux-de-Fonds. Read More

    Irradiance-dependent UVB Photocarcinogenesis.
    Sci Rep 2016 Nov 21;6:37403. Epub 2016 Nov 21.
    Department of Dermatology, Kaohsiung Medical University Hospital, Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Ultraviolet B (UVB) radiation from the sun may lead to photocarcinogenesis of the skin. Sunscreens were used to protect the skin by reducing UVB irradiance, but sunscreen use did not reduce sunburn episodes. It was shown that UVB-induced erythema depends on surface exposure but not irradiance of UVB. Read More

    A robust impact assessment that informs actionable climate change adaptation: future sunburn browning risk in apple.
    Int J Biometeorol 2016 Nov 14. Epub 2016 Nov 14.
    Department of Economic Development, Jobs, Transport and Resources, Tatura, Australia.
    Climate change impact assessments are predominantly undertaken for the purpose of informing future adaptation decisions. Often, the complexity of the methodology hinders the actionable outcomes. The approach used here illustrates the importance of considering uncertainty in future climate projections, at the same time providing robust and simple to interpret information for decision-makers. Read More

    Predictors of Beagley-Gibson skin cast grade in older adults.
    Skin Res Technol 2016 Oct 26. Epub 2016 Oct 26.
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, TAS, Australia.
    Background And Purpose: The Beagley-Gibson (BG) grading system utilizes microtopographical skin changes to generate an individualized, objective estimate of cumulative, lifetime ultraviolet radiation (UVR) exposure. However, predictors of BG grade are ill-defined, particularly in older populations. The aim of this cross-sectional study was to describe the factors associated with skin damage as measured by the BG method in 835 community-dwelling older adults. Read More

    Prospective study of ultraviolet radiation exposure and risk of breast cancer in the United States.
    Environ Res 2016 Nov 18;151:419-427. Epub 2016 Aug 18.
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States.
    Although there are few environmental risk factors for breast cancer, some epidemiologic studies found that exposure to solar UV radiation (UVR) may lower risk. Prior epidemiologic studies are limited by narrow ambient UVR ranges and lack lifetime exposure assessment. To address these issues, we studied a cohort with residences representing a wide range of ambient UVR. Read More

    Sun Protection Habits and Attitudes Among Healthcare Personnel in a Mediterranean Population.
    J Cancer Educ 2016 Dec;31(4):789-795
    Dermatology Department, University of Málaga, Málaga, Spain.
    Health professionals are key agents in healthcare promotion. In the field of skin cancer, they play a crucial role in the development of prevention strategies in the community. This paper aims to describe the sun exposure attitudes and habits of public healthcare professionals in the western Costa del Sol (Spain). Read More

    [Sosnowsky's hogweed - toxicology and threat to health].
    Pol Merkur Lekarski 2016 Sep;41(243):165-168
    Medical University of Wrocław, Poland: Faculty of Medicine.
    Sosnowsky's hogweed (Heracleum sosnowskyi Manden.) is a genus of plants in the family Apiaceae which also includes Giant Hogweed (Heracleum mantegazzianum Sommier and Levier). They are both found in Central Europe, mainly in neglected green areas or riversides. Read More

    Determining an Effective UV Radiation Exposure Time for Vitamin D Synthesis in the Skin Without Risk to Health: Simplified Estimations from UV Observations.
    Photochem Photobiol 2016 Nov;92(6):863-869
    Center for Global Environmental Research, National Institute for Environmental Studies, Tsukuba, Ibaraki, 305-8506, Japan.
    UV radiation contains erythemally weighted UV, as well as UV that synthesizes vitamin D3 . Here, we attempted to determine the relationship between these factors by numerical simulation of atmospheric parameters, such as total ozone, using a simplified "SMART2" model for radiative transfer. Both forms of UV were almost linearly correlated with each other for a comparably large UV radiation exposure, larger than UV Index ~1. Read More

    Seasonal and Geographic Variation in Adverse Event Reporting.
    Drugs Real World Outcomes 2016 Sep;3(3):297-306
    Pfizer Inc., New York, NY, USA.
    Background: Many illnesses demonstrate seasonal and geographic variations. Pharmacovigilance is unique among public health surveillance systems in terms of the clinical diversity of the events under surveillance. Since many pharmacovigilance signal detection methodologies are geared towards looking for increased frequency of spontaneous adverse drug event (ADE) reporting over variable time frames, seasonality of ADEs may have implications for signal detection. Read More

    Association of Indoor Tanning Frequency With Risky Sun Protection Practices and Skin Cancer Screening.
    JAMA Dermatol 2016 Oct 12. Epub 2016 Oct 12.
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Importance: Indoor tanning is prevalent among young adults and women and is associated with increased risk of melanoma. Evidence suggests that indoor tanners may be more inclined to adopt poor photoprotective practices that further increase their risk of skin cancer; however, gaps in the literature exist in young adults and by indoor tanning frequency.

    Objective: To examine the association between indoor tanning frequency and behaviors related to skin cancer prevention and to investigate whether these associations vary by age group or sex. Read More

    Herbal extracts, lichens and biomolecules as natural photo-protection alternatives to synthetic UV filters. A systematic review.
    Fitoterapia 2016 Oct 15;114:144-162. Epub 2016 Sep 15.
    School of Pharmacy and Health Products, Department of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, Via L. Borsari 46, 44121 Ferrara, Italy; Ambrosialab Srl, Via Mortara 171, 44121 Ferrara, Italy.
    Besides the unquestionable positive effects of solar exposure for human health, UV rays have been widely investigated for toxicology aspects related to excessive UVB and UVA doses, which involve sunburns, skin aging, DNA skin damage and tumorigenesis. At present, synthetic and mineral sunscreens are used to protect against these damages but several natural molecules can provide UV protection, including also synergic effect or enhanced photo stability. Although a large number of herbal extracts and plant origin molecules can deserve potential applications, most of the study reported utilizes different method and different strategies of investigation, making thus difficult to understand the real versus claimed potential. Read More

    Recent advances in understanding vitiligo.
    F1000Res 2016 6;5. Epub 2016 Sep 6.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, 10016, USA.
    Vitiligo, an acquired depigmentation disorder, manifests as white macules on the skin and can cause significant psychological stress and stigmatization. Recent advances have shed light on key components that drive disease onset and progression as well as therapeutic approaches. Vitiligo can be triggered by stress to the melanin pigment-producing cells of the skin, the melanocytes. Read More

    Salidroside's Protection Against UVB-Mediated Oxidative Damage and Apoptosis Is Associated with the Upregulation of Nrf2 Expression.
    Photomed Laser Surg 2017 Jan 14;35(1):49-56. Epub 2016 Sep 14.
    3 Key Laboratory of Mental Health, Institute of Psychology , Chinese Academy of Sciences, Beijing, P.R. China .
    Background: Salidroside is the major active component of Rhodiola rosea, a traditional Chinese herbal medicine used for protection against ultraviolet (UV) radiation.

    Objectives: This study investigated whether salidroside can protect skin from ultraviolet B (UVB)-induced oxidative damage in human immortalized HaCaT keratinocytes and the skin of guinea pigs.

    Methods: Using HaCaT cell models, the effects of salidroside on oxidative damage and possible regulatory factors [including NF-E2-related factor 2 (Nrf2), NAD(P)H-quinone oxidoreductase (NQO1), and heme oxygenase 1 (HO-1)] were examined. Read More

    Polyphenols and Sunburn.
    Int J Mol Sci 2016 Sep 9;17(9). Epub 2016 Sep 9.
    Department of Dermatology, University of California, Davis, Sacramento, CA 95816, USA.
    Polyphenols are antioxidant molecules found in many foods such as green tea, chocolate, grape seeds, and wine. Polyphenols have antioxidant, anti-inflammatory, and antineoplastic properties. Growing evidence suggests that polyphenols may be used for the prevention of sunburns as polyphenols decrease the damaging effects of ultraviolet A (UVA) and ultraviolet B (UVB) radiation on the skin. Read More

    Redox proteomic evaluation of oxidative modification and recovery in a 3D reconstituted human skin tissue model exposed to UVB.
    Int J Cosmet Sci 2016 Sep 10. Epub 2016 Sep 10.
    Food & Bio-Based Products, AgResearch Ltd, Private Bag 4749, Christchurch 8140, New Zealand.
    Objective: Exposure to UV in humans resulting in sunburn triggers a complex series of events that are a mix of immediate and delayed damage mediation and healing. While studies on the effects of UV exposure on DNA damage and repair have been reported, changes in the oxidative modification of skin proteins are poorly understood at the molecular level, despite the important role played by structural proteins in skin tissue, and the effect of the integrity of these proteins on skin appearance and health. Proteomic molecular mapping of oxidation was here applied to try to enhance understanding of skin damage and recovery from oxidative damage and UVB exposure. Read More

    Clinical and molecular epidemiological study of xeroderma pigmentosum in China: A case series of 19 patients.
    J Dermatol 2017 Jan 8;44(1):71-75. Epub 2016 Sep 8.
    Department of Dermatology, Peking University First Hospital, Beijing, China.
    Xeroderma pigmentosum (XP) is a rare genetic disorder which is divided into eight complementation groups: XP-A to XP-G and XP-V. Some XP patients demonstrate severe cutaneous and neurological manifestations, management of which requires timely diagnosis and intervention. We performed clinical evaluation and genetic analysis on 19 patients, the largest cohort of XP to date in China. Read More

    Chemical characterization of sunscreens composition and its related potential adverse health effects.
    J Cosmet Dermatol 2016 Sep 5. Epub 2016 Sep 5.
    College of Arts and Sciences, American University of Kuwait, Safat, Kuwait.
    Although the sun is very beneficial and essential for life, exposing ourselves too much to sunlight might lead to detrimental health effects such as skin cancer. Eight percent of the total different electromagnetic radiation that regularly irradiates the earth is classified as ultraviolet (UV) radiation. The ozone layer absorbs the most energetic UV rays; consequently, UV-A and UV-B reach the earth surface. Read More

    Protective and therapeutic effects of fucoxanthin against sunburn caused by UV irradiation.
    J Pharmacol Sci 2016 Sep 12;132(1):55-64. Epub 2016 Aug 12.
    Molecular Toxicology Lab., Ritsumeikan University, Shiga, Japan. Electronic address:
    Mild exposure to ultraviolet (UV) radiation is also harmful and hazardous to the skin and often causes a photosensitivity disorder accompanied by sunburn. To understand the action of UV on the skin we performed a microarray analysis to isolate UV-sensitive genes. We show here that UV irradiation promoted sunburn and downregulated filaggrin (Flg); fucoxanthin (FX) exerted a protective effect. Read More

    Sun-Protective Behaviors of Student Spectators at Inter-school Swimming Carnivals in a Tropical Region Experiencing High Ambient Solar Ultraviolet Radiation.
    Front Public Health 2016 16;4:168. Epub 2016 Aug 16.
    Skin Cancer Research Unit, Division of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, QLD, Australia; Discipline of Pharmacy, Division of Tropical Health and Medicine, College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.
    Skin cancer is the most common cancer in humans and Australia (particularly in Queensland) has the highest incidence globally. Sunlight is a known skin carcinogen and reflects off water, exacerbating the risk of sunburn. In 1988, the "SunSmart Program" was developed to promote sun-protection to Australian children. Read More

    Baicalin Scavenged Reactive Oxygen Species and Protected Human Keratinocytes Against UVB-induced Cytotoxicity.
    In Vivo 2016 09-10;30(5):605-10
    Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan, R.O.C.
    Ultraviolet B (UVB), with a wavelength of 280-320 nm, represents one of the most important environmental factors for skin disorders, including sunburn, hyperpigmentation, solar keratosis, solar elastosis and skin cancer. Therefore, protection against excessive UVA-induced damage is useful for prevention of sunburn and other human diseases. Baicalin, a major component of traditional Chinese medicine Scutellaria baicalensis, has been reported to possess antioxidant and cytostatic capacities. Read More

    Protective Effect of Curcumin Against Acute Ultraviolet B Irradiation-induced Photo-damage.
    Photochem Photobiol 2016 Nov 23;92(6):808-815. Epub 2016 Sep 23.
    Guangzhou Institute of Dermatology, Guangzhou, China.
    Ultraviolet B (UVB) irradiation is one of the most dangerous insults for skin and causes sunburn, erythema, photoaging and photocarcinogenesis. Curcumin (diferuloylmethane), a yellow spice derived from dried rhizomes of Curcuma longa, has been shown to possess significant anti-inflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant and anti-infective effects. However, the protective effects of curcumin against acute photo-damage are poorly understood. Read More

    A retrospective study of the utility of targeted phototherapy in vitiligo.
    Indian J Dermatol Venereol Leprol 2016 Aug 4. Epub 2016 Aug 4.
    Department of Dermatology, Disha Skin and Laser Institute, Thane, Maharashtra, India.
    Background: Targeted phototherapy is a recent advance in the treatment of vitiligo, involving selective treatment of vitiligo patches with no effect on surrounding areas. Although it has been in use for a few years, little data is available regarding its safety and efficacy.

    Aims: A retrospective study to determine efficacy and safety of targeted phototherapy in vitiligo. Read More

    Carotenoids as a Source of Antioxidants in the Diet.
    Subcell Biochem 2016 ;79:359-75
    Food Phytochemistry Department, Instituto de la Grasa (CSIC), Building 46, Campus Pablo de Olavide, 41013, Sevilla, Elija un Estado, España.
    Carotenoids, widely distributed fat-soluble pigments, are responsible for the attractive colorations of several fruits and vegetables commonly present in our daily diet. They are particularly abundant in yellow-orange fruits (carrots, tomatoes, pumpkins, peppers, among others) and, although masked by chlorophylls, in dark green leafy vegetables. Several health benefits have been attributed to carotenoids or to foods rich in these pigments, by means of different mechanisms-of-action, including the role as provitamin A of almost 50 different carotenoids and the antioxidant activity that protects cells and tissues from damage of free radicals and singlet oxygen, providing enhancement of the immune function, protection from sunburn reactions and delaying the onset of certain types of cancer. Read More

    Protective Effects of Soy Oligopeptides in Ultraviolet B-Induced Acute Photodamage of Human Skin.
    Oxid Med Cell Longev 2016 12;2016:5846865. Epub 2016 Jul 12.
    Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
    Aim. We explored the effects of soy oligopeptides (SOP) in ultraviolet B- (UVB-) induced acute photodamage of human skin in vivo and foreskin ex vivo. Methods. Read More

    Attitudes, Beliefs, and Measures Taken by Parents to Protect Their Children from the Sun in Guangzhou City, China.
    Photochem Photobiol 2016 Sep 19;92(5):753-9. Epub 2016 Aug 19.
    Department of Dermatology & Venerology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
    Excessive sun exposure can cause sunburn, suntan, skin photoaging, and even skin cancer. Skin photoaging conflicts with the human pursuit of a young and beautiful appearance. Some research data indicate that the incidence of skin cancer in the Chinese has been increasing, although it remains lower than in whites. Read More

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