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    Protective effects of an extract of the freshwater microalga Scenedesmus rubescens on UV-irradiated skin cells.
    Int J Cosmet Sci 2018 Feb 13. Epub 2018 Feb 13.
    DSM Nutritional Products, Personal Care, Wurmisweg 576, CH-4303, Kaiseraugst, Switzerland.
    Background: Skin aging results from intrinsic but also extrinsic factors of which UV-irradiation is a main cause. It is hence of interest to have means to protect skin from UV -irradiation induced damage. We selected an extract of the freshwater microalga Scenedesmus rubescens and assessed its potential to protect skin from photoaging caused by UV-irradiation. Read More

    Skin cancer interventions across the cancer control continuum: A review of experimental evidence (1/1/2000-6/30/2015) and future research directions.
    Prev Med 2018 Feb 6. Epub 2018 Feb 6.
    National Cancer Institute, United States.
    While the general efficacy of skin cancer interventions have been reviewed, employing the cancer control continuum would be useful to identify research gaps at specific cancer control points. We characterized the intervention evidence base for specific behavioral targets (e.g. Read More

    Cerebellar ataxia-dominant phenotype in patients with ERCC4 mutations.
    J Hum Genet 2018 Feb 5. Epub 2018 Feb 5.
    Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
    Autosomal recessive cerebellar ataxias (ARCAs) are clinically and genetically heterogeneous neurological disorders. Through whole-exome sequencing of Japanese ARCA patients, we identified three index patients from unrelated families who had biallelic mutations in ERCC4. ERCC4 mutations have been known to cause xeroderma pigmentosum complementation group F (XP-F), Cockayne syndrome, and Fanconi anemia phenotypes. Read More

    Isocitrate dehydrogenase 2 deficiency exacerbates dermis damage by ultraviolet-B via ΔNp63 downregulation.
    Biochim Biophys Acta 2018 Jan 31;1864(4 Pt A):1138-1147. Epub 2018 Jan 31.
    School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Taegu, Republic of Korea. Electronic address:
    Isocitrate dehydrogenase 2 (IDH2) is a key enzyme that maintains the balance of mitochondrial redox status by generating NADPH as a reducing factor, which is used to reduce oxidized antioxidant proteins and oxidized glutathione. Therefore, the role of IDH2 is crucial in organs that are easily influenced by reactive oxygen species (ROS) or mechanical damage. Humans are constantly exposed to ultraviolet (UV) radiation throughout their lifetime, which can cause various cutaneous diseases, such skin carcinoma, dermatitis, and sunburn. Read More

    UV-B-Induced Erythema in Human Skin: The Circadian Clock Is Ticking.
    J Invest Dermatol 2018 Feb;138(2):248-251
    Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington, USA; Sleep and Performance Research Center, Washington State University, Spokane, Washington, USA. Electronic address:
    Acute exposure of skin to UV-B causes DNA damage and sunburn erythema in both mice and humans. Previous studies documented time-of-day-related differences in sunburn responses after UV-B exposure in mice. Because humans are diurnal and mice are nocturnal, the circadian rhythm in human skin was hypothesized to be in opposite phase to the rhythm in mice. Read More

    Evaluation of the UVB-screening capacity and restorative effects exerted by farnesol gel on UVB-caused sunburn.
    Environ Toxicol 2018 Jan 30. Epub 2018 Jan 30.
    Department of Biomedical Engineering, I-Shou University, Kaohsiung City, Taiwan.
    Farnesol, a natural 15-carbon organic compound, has various microbiological and cellular activities. It has been found to exert apoptosis-inducing effects against carcinoma cells as well as antiallergic and anti-inflammatory effects in vivo. In the current study, a series of formulations composed of various concentrations of hydroxypropyl methylcellulose (HPMC) with the addition of hyaluronan (HA) and xanthan gum (XG) was designed to evaluate the UVB-screening and HO-eliminating effects of farnesol in normal fibroblasts. Read More

    Sun Protection Behaviors in Head Start and Other Early Childhood Education Programs in Illinois.
    JAMA Dermatol 2018 Jan 24. Epub 2018 Jan 24.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
    Importance: Sun safety attitudes developed in early childhood can reduce lifetime UV radiation exposure and the risk of skin cancer.

    Objective: To assess the current policies, practices, and attitudes among caregivers regarding sun protection in children aged 2 to 6 years.

    Design, Setting, And Participants: A survey of 202 administrators or managers and teachers of Illinois Head Start/Early Head Start (HS/EHS) and day care centers was conducted from July 3 through 21, 2017. Read More

    Persea americana Mill. crude extract exhibits antinociceptive effect on UVB radiation-induced skin injury in mice.
    Inflammopharmacology 2018 Jan 11. Epub 2018 Jan 11.
    Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
    Persea americana, popularly known as avocado, has been empirically used as analgesic and anti-inflammatory including in the skin disorder treatment. Species of the genus Persea also show a photoprotective effect against UVB radiation. We investigated the antinociceptive and anti-inflammatory effects from a topical formulation containing the P. Read More

    Preclinical evaluation of melanocyte transplantation by chitosan-based melanocyte spheroid patch to skin prepared by controlled sunburn blistering.
    J Biomed Mater Res B Appl Biomater 2018 Jan 10. Epub 2018 Jan 10.
    Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
    Transplantation of autologous cultured melanocytes as cell suspension has been used for the treatment of vitiligo. The recipient site is often prepared by laser-mediated dermabrasion. Such procedures encounter disadvantages including prolonged transplantation duration, unsecured cell adherence to lesional skin and potential scarring. Read More

    SPF 100+ sunscreen is more protective against sunburn than SPF 50+ in actual use: Results of a randomized, double-blind, split-face, natural sunlight exposure clinical trial.
    J Am Acad Dermatol 2017 Dec 29. Epub 2017 Dec 29.
    New York University School of Medicine, New York, New York. Electronic address:
    Background: The value of additional photoprotection provided by use of high-sun protection factor (SPF) sunscreens is controversial, and limited clinical evidence exists.

    Objective: To compare the sunburn protection provided by SPF 100+ and SPF 50+ sunscreen in conditions of actual use.

    Methods: A total of 199 healthy men and women (≥18 years) participated in a natural sunlight, single-exposure, split-face, randomized, double-blind study in Vail, Colorado. Read More

    How many melanomas might be prevented if more people applied sunscreen regularly?
    Br J Dermatol 2018 Jan 14;178(1):140-147. Epub 2017 Dec 14.
    Population Health Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland, 4006, Australia.
    Background: Ultraviolet radiation causes cutaneous melanoma. Sunscreen prevents sunburn and protects skin cells against mutations. High-quality epidemiological studies suggest regular sunscreen use prevents melanoma. Read More

    Promoting early detection of melanoma during the mammography experience.
    Int J Womens Dermatol 2017 Dec 5;3(4):195-200. Epub 2017 Jul 5.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL.
    Background: Invasive melanoma, a lethal form of skin cancer, is the seventh most common cancer in women. Factors such as a history of indoor tanning or sunburn and a personal or family history of skin cancer increase a woman's risk of developing a melanoma.

    Objective: Because the majority of melanomas occur in patients age 40 years or older, which is the age that is recommended for women to begin screening mammograms, the mammogram experience could be used to promote early detection of melanoma by introducing skin self-examinations (SSE) to a population of women who are already invested in preventive health. Read More

    Cutaneous melanoma primary site is linked to nevus density.
    Oncotarget 2017 Nov 24;8(58):98876-98886. Epub 2017 Oct 24.
    Department of Dermatology, Instituto Valenciano de Oncologia (IVO), Valencia, Spain.
    There are at least two pathways driving cutaneous melanoma; one is linked to an inherent melanoma susceptibility to nevi development and the second to environmental cumulative ultraviolet light exposure. In this study, we examined the relation between nevus density, accrued sun damage and the site of primary melanoma excision. In a series of 888 consecutive cutaneous melanoma patients, melanomas appearing in skin areas with a high relative nevus density were most prominent in men, with an elevated nevus count, at sites without solar elastosis, but with an epidemiological history of previous sunburn. Read More

    Assessment of temperature and ultraviolet radiation effects on sunburn incidence at an inland U.S. Beach: A cohort study.
    Environ Res 2018 Feb;161:479-484
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, 1841 Neil Ave., 406 Cunz Hall, Columbus, OH 43210, USA. Electronic address:
    Background: Increases in outdoor temperature may lead to increases in sunburn, outdoor exposure, and skin cancer in human populations.

    Objective: This study aimed to quantify sunburn incidence and risk for Ohio beachgoers exposed to varying outdoor conditions.

    Methods: Sunburn incidence data were obtained through a prospective cohort study at East Fork Lake (Cincinnati, Ohio, USA). Read More

    Topical application of ST266 reduces UV-induced skin damage.
    Clin Cosmet Investig Dermatol 2017 10;10:459-471. Epub 2017 Nov 10.
    Department of Dermatology, Case Western Reserve University.
    Ultraviolet radiation (UVR) has a significant impact on human skin and is the major environmental factor for skin cancer formation. It is also believed that 80% of the signs of skin aging are attributed to UVR. UVR induces inflammatory changes in the skin via the increase in oxidative stress, DNA damage vascular permeability, and fluctuation in a myriad of cytokines. Read More

    Clinical and genetic characteristics of xeroderma pigmentosum in Nepal.
    J Eur Acad Dermatol Venereol 2017 Nov 24. Epub 2017 Nov 24.
    Department of Dermatology, Robert Debré Hospital, Reims, France.
    Background: Little is known about xeroderma pigmentosum (XP) in Himalayan countries.

    Objective: To describe clinical characteristics of XP in Nepal and investigate its genetic bases.

    Methods: This study was carried out on all consecutive patients referred for XP to a Nepalese tertiary referral centre in 2014-2015. Read More

    A Randomized Trial of an Advanced Sun Safety Intervention for Vacationers at 41 North American Resorts.
    J Health Commun 2017 Dec 21;22(12):951-963. Epub 2017 Nov 21.
    e School of Public Health , University of Alabama at Birmingham , Birmingham , Alabama , USA.
    Taking vacations in sunny locations is associated with the development of skin cancer. This study tested a multi-component sun protection intervention based on diffusion of innovations theory and transportation theory designed to increase vacationers' comprehensive sun protection, i.e. Read More

    Prevalence of sun protection behaviors in Hispanic youth residing in a high ultraviolet light environment.
    Pediatr Dermatol 2018 Jan 21;35(1):e52-e54. Epub 2017 Nov 21.
    Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
    Although rates of late-stage melanoma are rising in Hispanics, particularly those living in high ultraviolet light environments, little is known about the prevalence of sun protective behaviors in Hispanic children. We analyzed baseline data including frequency of sunburn, sun protective behaviors, level of U.S. Read More

    Patients with Spitz naevi in the Greek population: Epidemiologic, Clinical and Histopathological characteristics.
    J Eur Acad Dermatol Venereol 2017 Nov 17. Epub 2017 Nov 17.
    1st University Department of Dermatology - Venereology, "Andreas Sygros" Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
    Background: Spitz naevi may present with clinical and histopathological atypical features that do not affect patient prognosis but may become worrisome for patients ≥40 years presenting with newly appearing SN.

    Objective: Patient characteristics and sun behaviour patterns were investigated in correlation with age. SN characteristics and histopathological attributes were also investigated in correlation with age. Read More

    Development and Evaluation of Lipid Nanoparticles Containing Natural Botanical Oil for Sun Protection: Characterization and in vitro and in vivo Human Skin Permeation and Toxicity.
    Skin Pharmacol Physiol 2017 Nov 4;31(1):1-9. Epub 2017 Nov 4.
    Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Departamento de Ciências Farmacêuticas, Universidade Federal de São Paulo, UNIFESP-Diadema, São Paulo, Brazil.
    The use of sunscreen products is widely promoted by schools, government agencies, and health-related organizations to minimize sunburn and skin damage. In this study, we developed stable solid lipid nanoparticles (SLNs) containing the chemical UV filter octyl methoxycinnamate (OMC). In parallel, we produced similar stable SLNs in which 20% of the OMC content was replaced by the botanical urucum oil. Read More

    Consumption of ellagic acid and dihydromyricetin synergistically protects against UV-B induced photoaging, possibly by activating both TGF-β1 and wnt signaling pathways.
    J Photochem Photobiol B 2018 Jan 7;178:92-100. Epub 2017 Nov 7.
    Dept. of Food & Nutrition, Obesity/Diabetes Center, Hoseo University, Asan, South Korea. Electronic address:
    Ellagic acid (EGA) and dihydromyricetin (DHM) are both found in fruits and vegetables are used for anti-aging treatment for the skin. The anti-photoaging efficacy of EGA and DHM was investigated in UV-B irradiated skin in vivo and the involvement of transforming growth factor (TGF)-β1 and wnt signaling pathways were examined in vitro. HaCaT cells were treated with either 50μM EGA, 50μM DHM or 25μM EGA+25μM DHM before 100mJ/cmUV-B exposure, and then oxidative stress and inflammation was measured. Read More

    Counseling on Sun Protection and Indoor Tanning.
    Pediatrics 2017 Dec 10;140(6). Epub 2017 Nov 10.
    Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia.
    Background: The US Preventive Services Task Force recommends clinical counseling for individuals ages 10 to 24 years to decrease skin cancer risk.

    Methods: A national, random sample of US American Academy of Pediatrics members practicing primary care in 2002 (response rate 55%) and 2015 (response rate 43%). Surveys explored attitudes and experiences regarding sun protection counseling; indoor tanning questions were added in 2015. Read More

    Ultraviolet Photobiology in Dermatology.
    Adv Exp Med Biol 2017 ;996:89-104
    Department of Dermatology, UH Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, OH, 44106, USA.
    The effects of ultraviolet radiation on human skin have been studied for years, and both its harmful and therapeutic effects are well known. Exposure to UV light can lead to sunburn, immunosuppression, skin aging, and carcinogenesis, and photoprotection is strongly advocated. However, when used under controlled conditions, UV radiation can also be helpful in the diagnosis and treatment of many skin conditions. Read More

    Ultraviolet radiation and skin cancer risk in offshore workers.
    Occup Med (Lond) 2017 Oct;67(7):569-573
    Department of Research, Cancer Registry of Norway, N-0304 Oslo, Norway.
    Background: Excess skin cancer mortality and incidence have been reported among both land-based and offshore petroleum workers. The association between skin cancer and ultraviolet radiation (UVR) exposure has not been examined in these workers, although they have long off-duty periods and high average income that may allow travelling to sunny destinations. In addition, they have access to solariums free of charge on many accommodation platforms. Read More

    Histological observation of hairless mice skin after exposure to Simulated Solar Light: Comparison between the histological findings with different methodologies and 3R principle correlations.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Laboratório de Microbiologia e Avaliação Genotóxica, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Albino hairless mouse (AHM) has been used as a biological model in photodermatology. However, the experimental landscape is diverse to follow and need particular attention.

    Purpose: Irradiation parameters were investigated for the development of a protocol to assess alterations in the AHM skin using Simulated Solar Light (SSL). Read More

    Managing actinic keratosis in primary care.
    Practitioner 2016 10;260(1797):25-9
    Actinic, or solar, keratosis is caused by chronic ultraviolet-induced damage to the epidermis. In the UK, 15-23% of individuals have actinic keratosis lesions. Risk factors include: advanced age; male gender; cumulative sun exposure or phototherapy; Fitzpatrick skin phototypes I-II; long-term immuno-suppression and genetic syndromes e. Read More

    Prevalence and predictors of sunburn among beachgoers.
    Photodermatol Photoimmunol Photomed 2017 Oct 4. Epub 2017 Oct 4.
    Cátedra de Dermatología, Universidad de Málaga, Málaga, Spain.
    Background: Painful sunburns at any age are one of the main risk factors for skin cancer.

    Objectives: To determine the prevalence and predictors of sunburn among beachgoers.

    Methods: A cross-sectional health survey was conducted at the beach during the summer. Read More

    Vitamin D Prevents Sunburn: Tips for the Summer?
    J Invest Dermatol 2017 Oct;137(10):2045-2047
    Department of Medicine, VA Medical Center, San Francisco, California, USA; and University of California San Francisco, San Francisco, California, USA. Electronic address:
    In the article by Scott et al, a high dose of vitamin D attenuated the inflammatory response to UV radiation in a small group of normal volunteers. The best results were in those subjects who had the greatest increase in circulating 25hydroxyvitamin D. Using microarray analyses these subjects showed a reduction in the expression of inflammatory markers with an increase in markers of skin barrier repair. Read More

    Medical and psychological problems faced by young Australian gap year travellers.
    J Travel Med 2017 Sep;24(5)
    Travel Medicine Alliance Clinics, 47 Adelaide Street, 47 Adelaide Street, Brisbane, QLD 4000, Australia.
    Background: Gap year travellers can potentially be exposed to many infectious diseases and other travel-related health problems including injuries and psychological problems. Currently, there is little information on health and wellbeing of this particular group of travellers.

    Methods: Participants were recruited from an organization that specialized in organising international gap year placements. Read More

    Cutaneous malignant melanoma incidences analyzed worldwide by sex, age, and skin type over personal Ultraviolet-B dose shows no role for sunburn but implies one for Vitamin D.
    Dermatoendocrinol 2017 14;9(1):e1267077. Epub 2016 Dec 14.
    Marquette University, Department of Mathematics, Statistics, and Computer Science, Milwaukee, WI, USA.
    Because the incidence of cutaneous malignant melanoma (CMM) was reported to increase with increasing terrestrial UVR (290-400 nm) doses in the US back in 1975 and a recent publication showed no association exists with UVR exposure at all, we set out to fully elucidate the role of UVR in CMM. To achieve this goal, we analyzed the CMM incidences over latitude and estimated the average personal UVR dose in the US and numerous countries (> 50) on 5 continents around the world. Using data from the International Agency for Research on Cancer in 2005, we performed worldwide analysis of CMM over UVR dose by sex, age group (0-14, 15-29, 30-49, 50-69, 70-85+) and Fitzpatrick skin types I-VI. Read More

    An open-label clinical trial assessing the efficacy and safety of Bend Skincare Anti-Aging Formula on minimal erythema dose in skin.
    Photodermatol Photoimmunol Photomed 2017 Sep 8. Epub 2017 Sep 8.
    Bend Beauty Inc., Halifax, NS, Canada.
    Background/purpose: Sunburn and other health risks associated with excess sun exposure place huge economic burdens on societies, and create discomfort and disease within susceptible individuals. Oral supplements that reduce sunburn may be advantageous. This study evaluated the safety and efficacy of Bend Skincare Anti-Aging Formula to ameliorate sunburn induced with a solar simulator. Read More

    Safety of antimalarial medications for use while scuba diving in malaria Endemic Regions.
    Trop Dis Travel Med Vaccines 2016 11;2:23. Epub 2016 Oct 11.
    Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
    Background: Recreational diving occurs annually in areas of the world where malaria is endemic. The safety and efficacy of antimalarials for travelers in a hyperbaric environment is unknown. Of particular concern would be medications with adverse effects that could either mimic diving related illnesses such as barotrauma, decompression sickness (DCS) and gas toxicities, or increase the risk for such illnesses. Read More

    CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.
    Proc Natl Acad Sci U S A 2017 Sep 6;114(38):E8035-E8044. Epub 2017 Sep 6.
    The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
    Casein kinase 1α (CK1α), a component of the β-catenin destruction complex, is a critical regulator of Wnt signaling; its ablation induces both Wnt and p53 activation. To characterize the role of CK1α (encoded by) in skin physiology, we crossed mice harboring floxedwith mice expressing K14-Cre-ERto generate mice in which tamoxifen induces the deletion ofexclusively in keratinocytes [single-knockout (SKO) mice]. As expected, CK1α loss was accompanied by β-catenin and p53 stabilization, with the preferential induction of p53 target genes, but phenotypically most striking was hyperpigmentation of the skin, importantly without tumorigenesis, for at least 9 mo afterablation. Read More

    Determinants of Sunburn and Sun Protection of Agricultural Workers During Occupational and Recreational Activities.
    J Occup Environ Med 2017 Nov;59(11):1089-1094
    University Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland (Ms Backes, Dr Bulliard); Institute for Work and Health (IST), University of Lausanne and Geneva, Lausanne, Switzerland (Ms Backes, Mr Milon, Dr Vernez); International Prevention Research Institute, Lyon, France (Ms Koechlin); and University of Strathclyde Institute for Global Public Health at iPRI, International Prevention Research Institute, Lyon, France (Ms Koechlin).
    Objective: The aim of this study was to identify determinants of occupational sunburn in agricultural workers and assess their occupational and recreational sun protection habits.

    Methods: Specific surveys of agricultural workers in Switzerland and France were conducted (N = 1538). Multivariate logistic regressions identified occupational sunburn determinants. Read More

    Topical application of Nexrutine inhibits ultraviolet B-induced cutaneous inflammatory responses in SKH-1 hairless mouse.
    Photodermatol Photoimmunol Photomed 2018 Jan 9;34(1):82-90. Epub 2017 Oct 9.
    Environmental Carcinogenesis Laboratory, Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
    Background: Ultraviolet B (UVB) radiation is the major contributor to skin inflammation which leads to the development of skin cancer. Hence, in this study, we studied the effect of Nexrutine (NX) on UVB-induced cutaneous inflammation and its mediators.

    Methods: Ultraviolet absorption spectra of NX were measured by spectrophotometer. Read More

    Sun protection by umbrellas and walls.
    Photochem Photobiol Sci 2017 Oct;16(10):1537-1545
    Johnson and Johnson Consumer Inc., Skillman, NJ 08558, USA.
    Solar protection is an important public health issue because solar UV exposure can cause acute and chronic damage to the skin. Seeking shade is a convenient and commonly practiced sun avoidance measure. Shade works by physically shielding the skin from direct UV rays; however UV rays can also reach the skin from other angles. Read More

    Real-time sun protection decisions in first-degree relatives of melanoma patients.
    Health Psychol 2017 Sep;36(9):907-915
    Department of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center.
    Objective: Melanoma is the most serious skin cancer, and consistent use of sun protection is recommended to reduce risk. Yet sun protection use is generally inconsistent. Understanding the decisional factors driving sun protection choices could aid in intervention development to promote sun protection maintenance. Read More

    Oxidized Polymeric Phenolics: Could They Be Considered Photoprotectors?
    J Agric Food Chem 2017 Sep 28;65(36):7843-7846. Epub 2017 Aug 28.
    Dipartimento di Scienze Agrarie e Ambientali (DISAA), Università degli Studi di Milano , via Celoria 2, 20133 Milano, Italy.
    Photooxidative sunburn is the consequence of photosystem overexcitations. It results in tissue color changes as a result of chlorophyll degradation and accumulation of oxidized polymeric phenolics (OPPs), resulting from scavenging of reactive oxygen species (ROS). From a productive point of view, OPPs should be considered as damages, decreasing the economical and esthetical values of plants and crops. Read More

    Juvenile melanomas: Western Australian Melanoma Advisory Service experience.
    Australas J Dermatol 2017 Nov 15;58(4):299-303. Epub 2017 Aug 15.
    St John of God Hospital, Perth, Western Australia, Australia.
    Background/objectives: Juvenile melanoma (before 20 years of age) is a rare condition with poorly defined risk factors. We describe features of juvenile melanoma in Western Australia over the last two decades.

    Method: A retrospective review of juvenile melanomas was conducted from prospectively maintained databases, reviewed for patients' characteristics, clinical information, histology, treatment, recurrence and survival data. Read More

    The Possible Pre- and Post-UVA Radiation Protective Effect of Amaranth Oil on Human Skin Fibroblast Cells.
    Pharmacogn Mag 2017 Jul 11;13(Suppl 2):S339-S343. Epub 2017 Jul 11.
    Department of Organic Chemistry, The Faculty of Pharmacy with the Division of Medical Analytics, Medical University of Bialystok, Białystok, Poland.
    Background: The health effects of Amaranth Oil (AO) are attributed to its specific chemical composition. That makes it an outstanding natural product for the prevention and treatment of ultraviolet (UV) irradiation-related pathologies such as sunburn, photoaging, photoimmunosuppression, and photocarcinogenesis. Most of the studies are taken on animal model, and there is a lack of research on the endogenous effect of AO on fibroblast level, where UVA takes it harmful place. Read More

    The untold story of the scorching sun-A wake up call for sun protection.
    Burns 2018 Feb 4;44(1):77-81. Epub 2017 Aug 4.
    Burns Unit, The Mid Yorkshire Hospitals NHS Trust, Pinderfields General Hospital, Aberford Rd, Wakefield WF1 4DG, UK. Electronic address:
    Despite extensive warnings from health authorities regarding the dangers of direct sunlight exposure, most people still turn to sun bathing to get a golden tan. Unfortunately, that pleasant tan appearance is often lost because of over exposure to sunlight, resulting in painful red sunburns. In this paper we are reporting a case with significant sunburn injuries that required hospitalization and treatment in a burn center. Read More

    Probabilistic exposure assessment of sun care products.
    Food Chem Toxicol 2017 Oct 22;108(Pt A):314-325. Epub 2017 Jul 22.
    Safety Assessment Department, Pierre Fabre Dermo Cosmetique, Allée Camille Soula - BP 74 Vigoulet Auzil, 31322, Castanet Tolosan, Cedex, France.
    The aim of this study has been to assess the consumption and the exposure to 6 types of sun care products: sunscreen cream, sunscreen milk, sunscreen spray, sunscreen stick, moisturizing cream with SPF and after-sun milk. Consumption data were obtained from 75 clinical safety studies conducted on 3001 subjects: 371 children aged 3-9, 149 children aged 10-14 and 2481 adults aged more than 15. Exposure was assessed using a probabilistic method. Read More

    Iris Freckles a Potential Biomarker for Chronic Sun Damage.
    Invest Ophthalmol Vis Sci 2017 05;58(6):BIO174-BIO179
    Department of Dermatology, Medical University of Graz, Graz, Austria.
    Purpose: To investigate the role of sunlight exposure in iris freckles formation.

    Methods: We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure. Read More

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