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    Children sustain high levels of skin DNA photodamage, with a modest increase of serum 25(OH)D , after a summer holiday in Northern Europe.
    Br J Dermatol 2018 Apr 24. Epub 2018 Apr 24.
    King's College London, St John's Institute of Dermatology, London, SE1 9RT, UK.
    Background: Childhood solar ultraviolet radiation (UVR) exposure increases the risk of skin cancer in adulthood, which is associated with mutations caused by UVR-induced cyclobutane pyrimidine dimers (CPD). Solar UVR is also the main source of vitamin D, essential for healthy bone development in children.

    Objectives: The impact of a 12-day Baltic Sea (54 N) beach holiday on serum 25-dihydroxyvitamin D (25(OH)D ) and CPD was assessed in 32 healthy Polish children (skin types I-IV). Read More

    Capturing Ultraviolet Radiation Exposure and Physical Activity: Feasibility Study and Comparison Between Self-Reports, Mobile Apps, Dosimeters, and Accelerometers.
    JMIR Res Protoc 2018 Apr 17;7(4):e102. Epub 2018 Apr 17.
    Institute of Health and Biomedical Innovation, School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia.
    Background: Skin cancer is the most prevalent cancer in Australia. Skin cancer prevention programs aim to reduce sun exposure and increase sun protection behaviors. Effectiveness is usually assessed through self-report. Read More

    Photoprotection in adolescents: what they know and how they behave.
    An Bras Dermatol 2018 Jan-Feb;93(1):39-44
    Department of Pediatrics, Hospital de Clínicas, Universidade Federal do Paraná (UFPR) - Curitiba (PR), Brazil.
    Background: The greatest sun exposure occurs until adolescence and this is the only factor involved in photocarcinogenesis subject to modification with photoprotection.

    Objective: The objective of this study was to evaluate the habits and knowledge of adolescents regarding photoprotection.

    Method: Cross-sectional study that included 512 students from primary and high school. Read More

    Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin.
    Front Pharmacol 2018 27;9:287. Epub 2018 Mar 27.
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, United States.
    Environmental exposure to solar ultraviolet (UV) radiation causes acute photodamage, premature aging, and skin cancer, attributable to UV-induced genotoxic, oxidative, and inflammatory stress. The transcription factor NRF2 [nuclear factor erythroid 2 (E2)-related factor 2] is the master regulator of the cellular antioxidant response protecting skin against various environmental stressors including UV radiation and electrophilic pollutants. NRF2 in epidermal keratinocytes can be activated using natural chemopreventive compounds such as the apocarotenoid bixin, an FDA-approved food additive and cosmetic ingredient from the seeds of the achiote tree (). Read More

    Dermoscopic features of melanocytic skin lesions in Greek children and adolescents and their association with environmental factors and skin types.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    First Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, Greece.
    Background: Acquired nevi often present in childhood and increase in number and size during early and middle life. As nevi represent potential mimickers off melanoma, the knowledge of their epidemiologic and morphologic characteristics, is essential.

    Objective: In this study, we intend to determine the prevalence of dermoscopic patterns of nevi, as well their association with environmental and constitutional factors. Read More

    Sun protection in children: a behavioural study.
    Eur J Dermatol 2018 Apr 5. Epub 2018 Apr 5.
    Centro Dermatologia Epidermis, Instituto CUF, Porto, Portugal, Portuguese Skin Cancer Association, Portugal, Center for Health Technology and Services Research (CINTESIS) and Department of Health Information and Decision Sciences, Faculty of Medicine, University of Porto, Portugal, Faculty of Medicine, University of Porto, Portugal.
    Background: Incidence of skin cancer is increasing worldwide and UV exposure at a young age is an important risk factor.

    Objectives: To compare sun exposure-related knowledge and behaviour among children during school and holiday periods. Material &Methods: A cross-sectional study was undertaken at 12 Oporto public primary schools. Read More

    A Specific Melon Concentrate Exhibits Photoprotective Effects from Antioxidant Activity in Healthy Adults.
    Nutrients 2018 Mar 31;10(4). Epub 2018 Mar 31.
    EA7288 Université de Montpellier, 34093 Montpellier CEDEX 5, France.
    Skin is the largest body organ and the first barrier to exogenous threats. This organ is constantly exposed to external factors such as ultraviolet radiation, which induces many adverse effects including sunburn, depigmentation, photo aging, photo immune suppression, and even skin cancer. Antioxidants seem to be good candidates in order to reduce ultraviolet-mediated damages and to prevent the health consequences of ultraviolet exposure. Read More

    Behavioral Counseling to Prevent Skin Cancer: US Preventive Services Task Force Recommendation Statement.
    JAMA 2018 03;319(11):1134-1142
    University of Hawaii, Honolulu.
    Importance: Skin cancer is the most common type of cancer in the United States. Although invasive melanoma accounts for only 2% of all skin cancer cases, it is responsible for 80% of skin cancer deaths. Basal and squamous cell carcinoma, the 2 predominant types of nonmelanoma skin cancer, represent the vast majority of skin cancer cases. Read More

    Behavioral Counseling for Skin Cancer Prevention: Evidence Report and Systematic Review for the US Preventive Services Task Force.
    JAMA 2018 03;319(11):1143-1157
    Kaiser Permanente Center for Health Research, Kaiser Permanente Research Affiliates Evidence-based Practice Center, Portland, Oregon.
    Importance: Exposure to UV radiation, especially in childhood, increases skin cancer risk.

    Objective: To systematically review the evidence on the benefits and harms of behavioral counseling for skin cancer prevention to inform the US Preventive Services Task Force (USPSTF).

    Data Sources: Cochrane Central Register of Controlled Trials, MEDLINE, and PubMed were searched for studies published from January 2009 to March 31, 2016, for skin cancer prevention and from August 2005 to March 31, 2016, for skin self-examination. Read More

    Reliability and consistency of a validated sun exposure questionnaire in a population-based Danish sample.
    Prev Med Rep 2018 Jun 10;10:43-48. Epub 2018 Feb 10.
    Department of Prevention and Information, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark.
    An important feature of questionnaire validation is reliability. To be able to measure a given concept by questionnaire validly, the reliability needs to be high. The objectives of this study were to examine reliability of attitude and knowledge and behavioral consistency of sunburn in a developed questionnaire for monitoring and evaluating population sun-related behavior. Read More

    Prevalence of Sun Protection Use and Sunburn and Association of Demographic and Behaviorial Characteristics With Sunburn Among US Adults.
    JAMA Dermatol 2018 Mar 14. Epub 2018 Mar 14.
    Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland.
    Importance: Monitoring sun protection and sunburn over time at the population level can provide valuable information about progress toward skin cancer prevention goals and inform future intervention efforts.

    Objective: To examine the prevalence of sun protection use (shade, sunscreen, and clothing) and sunburn and the association between sunburn and individual characteristics and health behaviors in the US population.

    Design, Setting, And Participants: In this cross-sectional study using a nationally representative sample of 31 162 US adults from the 2015 National Health Interview Survey-Cancer Control Supplement, household interviews of civilian, noninstitutionalized US adults were conducted throughout 2015 in person and completed on the telephone when necessary. Read More

    Sunburn at the seaside.
    Photodermatol Photoimmunol Photomed 2018 Mar 13. Epub 2018 Mar 13.
    Sequoia Scientific, Inc., Bellevue, WA, USA.
    Background/purpose: The purpose of this paper is to estimate the contribution to our erythemal exposure at the coast of solar ultraviolet (UV) both reflected from, and transmitted into, the ocean.

    Methods: The reflection of solar UV radiation from, and transmitted into, seawater was calculated using a numerical model under a number of atmospheric conditions to estimate erythemal exposure on the skin of supine/prone and ambulant people.

    Results: The results were expressed as UV Indices. Read More

    Decrease in artificial tanning by French teenagers: 2011-2016.
    Photodermatol Photoimmunol Photomed 2018 Mar 13. Epub 2018 Mar 13.
    Service de Dermatologie, Hôpital Victor Dupouy, Argenteuil, France.
    Background: The major risk factor for skin cancers is exposure to solar and artificial ultraviolet radiation, in particular during childhood and adolescence. In France, a law was restricted for tanning-bed access to adults (≥18 years) since 1997.

    Objective: To evaluate teenagers' artificial tanning behaviour in 2016 and to compare results with those obtained in a similar survey performed in 2011. Read More

    Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models.
    Pain 2018 Feb 24. Epub 2018 Feb 24.
    Center of Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
    As an indirect approach to relate previously identified sensory phenotypes of patients suffering from peripheral neuropathic pain to underlying mechanisms, we used a published sorting algorithm to estimate the prevalence of denervation, peripheral and central sensitization in 657 healthy subjects undergoing experimental models of nerve block (NB) (compression block and topical lidocaine), primary hyperalgesia (PH) (sunburn and topical capsaicin), or secondary hyperalgesia (intradermal capsaicin and electrical high-frequency stimulation), and in 902 patients suffering from neuropathic pain. Some of the data have been previously published. Randomized split-half analysis verified a good concordance with a priori mechanistic sensory profile assignment in the training (79%, Cohen κ = 0. Read More

    Phytohormone Interaction Modulating Fruit Responses to Photooxidative and Heat Stress on Apple ( Borkh.).
    Front Plant Sci 2017 14;8:2129. Epub 2017 Dec 14.
    Centro de Pomaceas, Facultad de Ciencias Agrarias, Universidad de Talca, Talca, Chile.
    Sun-related physiological disorders such as sun damage on apples ( Borkh) are caused by cumulative photooxidative and heat stress during their growing season triggering morphological, physiological, and biochemical changes in fruit tissues not only while it is on the tree but also after it has been harvested. The objective of the work was to establish the interaction of auxin (indole-3-acetic acid; IAA), abscisic acid (ABA), jasmonic acid (JA), salicylic acid (SA), and ethylene (ET) and its precursor ACC (free and conjugated, MACC) during development of sun-injury-related disorders pre- and post-harvest on apples. Peel tissue was extracted from fruit growing under different sun exposures (Non-exposed, NE; Exposed, EX) and with sun injury symptoms (Moderate, Mod). Read More

    The impact of ultraviolet radiation on sunburn-related search activity.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Department of Dermatology - San Antonio Military Medical Center, San Antonio, Texas.
    We establish a strong, positive relationship between the Ultraviolet Index and Google search engine activity for sunburn-related terms in the United States. Using the Google Trends utility and data available from the National Weather service, we combine data from a twelve-year period to produce panel data for each state. We fit a time-series regression model of search activity and perform statistical tests on the resulting parameter estimates. Read More

    Sanatoria revisited: sunlight and health.
    J R Coll Physicians Edinb 2017 Sep;47(3):276-280
    AR Butler, Medical School, University of St Andrews, St Andrews, Fife KY16 9AJ, UK. Email:
    Since the 18th century tuberculosis has been a major cause of death throughout the world. It is a highly infectious disease that spreads by droplet infection and finding effective treatment to combat tuberculosis took a great deal of time. One of the first treatments to have some real success was a stay in a sanatorium. Read More

    The photoprotective and anti-inflammatory activity of red propolis extract in rats.
    J Photochem Photobiol B 2018 Mar 31;180:198-207. Epub 2018 Jan 31.
    Universidade Tiradentes, Av. Murilo Dantas, 300, Farolânida, Aracaju, SE, Brazil; Instituto de Tecnologia e Pesquisa - ITP, Av. Murilo Dantas, 300, Farolânida, Aracaju, SE, Brazil.
    The negative effects triggered by ultraviolet radiation, such as premature aging and carcinogenesis, have motivated several studies on photoprotection. Recent strategies for photoprotection have included the incorporation of natural antioxidant and anti-inflammatory compounds, such as flavonoids, into sunscreens and the oral administration of natural antioxidant extracts. Brazilian Red propolis extract contains isoflavonoids with antioxidant and anti-inflammatory activities. Read More

    Protective effects of an extract of the freshwater microalga Scenedesmus rubescens on UV-irradiated skin cells.
    Int J Cosmet Sci 2018 Feb 13. Epub 2018 Feb 13.
    DSM Nutritional Products, Personal Care & Aroma, Wurmisweg 576, CH-4303, Kaiseraugst, Switzerland.
    Background: Skin ageing results from intrinsic but also extrinsic factors of which UV irradiation is a main cause. It is hence of interest to have means to protect skin from UV irradiation-induced damage. We selected an extract of the freshwater microalga Scenedesmus rubescens and assessed its potential to protect skin from photoageing caused by UV irradiation. Read More

    Skin cancer interventions across the cancer control continuum: A review of experimental evidence (1/1/2000-6/30/2015) and future research directions.
    Prev Med 2018 Feb 6. Epub 2018 Feb 6.
    National Cancer Institute, United States.
    While the general efficacy of skin cancer interventions have been reviewed, employing the cancer control continuum would be useful to identify research gaps at specific cancer control points. We characterized the intervention evidence base for specific behavioral targets (e.g. Read More

    Cerebellar ataxia-dominant phenotype in patients with ERCC4 mutations.
    J Hum Genet 2018 Apr 5;63(4):417-423. Epub 2018 Feb 5.
    Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
    Autosomal recessive cerebellar ataxias (ARCAs) are clinically and genetically heterogeneous neurological disorders. Through whole-exome sequencing of Japanese ARCA patients, we identified three index patients from unrelated families who had biallelic mutations in ERCC4. ERCC4 mutations have been known to cause xeroderma pigmentosum complementation group F (XP-F), Cockayne syndrome, and Fanconi anemia phenotypes. Read More

    Isocitrate dehydrogenase 2 deficiency exacerbates dermis damage by ultraviolet-B via ΔNp63 downregulation.
    Biochim Biophys Acta 2018 Apr 31;1864(4 Pt A):1138-1147. Epub 2018 Jan 31.
    School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Taegu, Republic of Korea. Electronic address:
    Isocitrate dehydrogenase 2 (IDH2) is a key enzyme that maintains the balance of mitochondrial redox status by generating NADPH as a reducing factor, which is used to reduce oxidized antioxidant proteins and oxidized glutathione. Therefore, the role of IDH2 is crucial in organs that are easily influenced by reactive oxygen species (ROS) or mechanical damage. Humans are constantly exposed to ultraviolet (UV) radiation throughout their lifetime, which can cause various cutaneous diseases, such skin carcinoma, dermatitis, and sunburn. Read More

    UV-B-Induced Erythema in Human Skin: The Circadian Clock Is Ticking.
    J Invest Dermatol 2018 Feb;138(2):248-251
    Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington, USA; Sleep and Performance Research Center, Washington State University, Spokane, Washington, USA. Electronic address:
    Acute exposure of skin to UV-B causes DNA damage and sunburn erythema in both mice and humans. Previous studies documented time-of-day-related differences in sunburn responses after UV-B exposure in mice. Because humans are diurnal and mice are nocturnal, the circadian rhythm in human skin was hypothesized to be in opposite phase to the rhythm in mice. Read More

    Evaluation of the UVB-screening capacity and restorative effects exerted by farnesol gel on UVB-caused sunburn.
    Environ Toxicol 2018 Apr 30;33(4):488-507. Epub 2018 Jan 30.
    Department of Biomedical Engineering, I-Shou University, Kaohsiung City, Taiwan.
    Farnesol, a natural 15-carbon organic compound, has various microbiological and cellular activities. It has been found to exert apoptosis-inducing effects against carcinoma cells as well as antiallergic and anti-inflammatory effects in vivo. In the current study, a series of formulations composed of various concentrations of hydroxypropyl methylcellulose (HPMC) with the addition of hyaluronan (HA) and xanthan gum (XG) was designed to evaluate the UVB-screening and H O -eliminating effects of farnesol in normal fibroblasts. Read More

    Sun Protection Behaviors in Head Start and Other Early Childhood Education Programs in Illinois.
    JAMA Dermatol 2018 Mar;154(3):336-340
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
    Importance: Sun safety attitudes developed in early childhood can reduce lifetime UV radiation exposure and the risk of skin cancer.

    Objective: To assess the current policies, practices, and attitudes among caregivers regarding sun protection in children aged 2 to 6 years.

    Design, Setting, And Participants: A survey of 202 administrators or managers and teachers of Illinois Head Start/Early Head Start (HS/EHS) and day care centers was conducted from July 3 through 21, 2017. Read More

    Persea americana Mill. crude extract exhibits antinociceptive effect on UVB radiation-induced skin injury in mice.
    Inflammopharmacology 2018 Jan 11. Epub 2018 Jan 11.
    Graduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
    Persea americana, popularly known as avocado, has been empirically used as analgesic and anti-inflammatory including in the skin disorder treatment. Species of the genus Persea also show a photoprotective effect against UVB radiation. We investigated the antinociceptive and anti-inflammatory effects from a topical formulation containing the P. Read More

    Preclinical evaluation of melanocyte transplantation by chitosan-based melanocyte spheroid patch to skin prepared by controlled sunburn blistering.
    J Biomed Mater Res B Appl Biomater 2018 Jan 10. Epub 2018 Jan 10.
    Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
    Transplantation of autologous cultured melanocytes as cell suspension has been used for the treatment of vitiligo. The recipient site is often prepared by laser-mediated dermabrasion. Such procedures encounter disadvantages including prolonged transplantation duration, unsecured cell adherence to lesional skin and potential scarring. Read More

    SPF 100+ sunscreen is more protective against sunburn than SPF 50+ in actual use: Results of a randomized, double-blind, split-face, natural sunlight exposure clinical trial.
    J Am Acad Dermatol 2018 May 29;78(5):902-910.e2. Epub 2017 Dec 29.
    New York University School of Medicine, New York, New York. Electronic address:
    Background: The value of additional photoprotection provided by use of high-sun protection factor (SPF) sunscreens is controversial, and limited clinical evidence exists.

    Objective: To compare the sunburn protection provided by SPF 100+ and SPF 50+ sunscreen in conditions of actual use.

    Methods: A total of 199 healthy men and women (≥18 years) participated in a natural sunlight, single-exposure, split-face, randomized, double-blind study in Vail, Colorado. Read More

    How many melanomas might be prevented if more people applied sunscreen regularly?
    Br J Dermatol 2018 Jan 14;178(1):140-147. Epub 2017 Dec 14.
    Population Health Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland, 4006, Australia.
    Background: Ultraviolet radiation causes cutaneous melanoma. Sunscreen prevents sunburn and protects skin cells against mutations. High-quality epidemiological studies suggest regular sunscreen use prevents melanoma. Read More

    Promoting early detection of melanoma during the mammography experience.
    Int J Womens Dermatol 2017 Dec 5;3(4):195-200. Epub 2017 Jul 5.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL.
    Background: Invasive melanoma, a lethal form of skin cancer, is the seventh most common cancer in women. Factors such as a history of indoor tanning or sunburn and a personal or family history of skin cancer increase a woman's risk of developing a melanoma.

    Objective: Because the majority of melanomas occur in patients age 40 years or older, which is the age that is recommended for women to begin screening mammograms, the mammogram experience could be used to promote early detection of melanoma by introducing skin self-examinations (SSE) to a population of women who are already invested in preventive health. Read More

    Cutaneous melanoma primary site is linked to nevus density.
    Oncotarget 2017 Nov 24;8(58):98876-98886. Epub 2017 Oct 24.
    Department of Dermatology, Instituto Valenciano de Oncologia (IVO), Valencia, Spain.
    There are at least two pathways driving cutaneous melanoma; one is linked to an inherent melanoma susceptibility to nevi development and the second to environmental cumulative ultraviolet light exposure. In this study, we examined the relation between nevus density, accrued sun damage and the site of primary melanoma excision. In a series of 888 consecutive cutaneous melanoma patients, melanomas appearing in skin areas with a high relative nevus density were most prominent in men, with an elevated nevus count, at sites without solar elastosis, but with an epidemiological history of previous sunburn. Read More

    Assessment of temperature and ultraviolet radiation effects on sunburn incidence at an inland U.S. Beach: A cohort study.
    Environ Res 2018 Feb;161:479-484
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, 1841 Neil Ave., 406 Cunz Hall, Columbus, OH 43210, USA. Electronic address:
    Background: Increases in outdoor temperature may lead to increases in sunburn, outdoor exposure, and skin cancer in human populations.

    Objective: This study aimed to quantify sunburn incidence and risk for Ohio beachgoers exposed to varying outdoor conditions.

    Methods: Sunburn incidence data were obtained through a prospective cohort study at East Fork Lake (Cincinnati, Ohio, USA). Read More

    Topical application of ST266 reduces UV-induced skin damage.
    Clin Cosmet Investig Dermatol 2017 10;10:459-471. Epub 2017 Nov 10.
    Department of Dermatology, Case Western Reserve University.
    Ultraviolet radiation (UVR) has a significant impact on human skin and is the major environmental factor for skin cancer formation. It is also believed that 80% of the signs of skin aging are attributed to UVR. UVR induces inflammatory changes in the skin via the increase in oxidative stress, DNA damage vascular permeability, and fluctuation in a myriad of cytokines. Read More

    Clinical and genetic characteristics of xeroderma pigmentosum in Nepal.
    J Eur Acad Dermatol Venereol 2018 May 18;32(5):832-839. Epub 2017 Dec 18.
    Department of Dermatology, Robert Debré Hospital, Reims, France.
    Background: Little is known about xeroderma pigmentosum (XP) in Himalayan countries.

    Objective: To describe clinical characteristics of XP in Nepal and investigate its genetic bases.

    Methods: This study was carried out on all consecutive patients referred for XP to a Nepalese tertiary referral centre in 2014-2015. Read More

    A Randomized Trial of an Advanced Sun Safety Intervention for Vacationers at 41 North American Resorts.
    J Health Commun 2017 Dec 21;22(12):951-963. Epub 2017 Nov 21.
    e School of Public Health , University of Alabama at Birmingham , Birmingham , Alabama , USA.
    Taking vacations in sunny locations is associated with the development of skin cancer. This study tested a multi-component sun protection intervention based on diffusion of innovations theory and transportation theory designed to increase vacationers' comprehensive sun protection, i.e. Read More

    Prevalence of sun protection behaviors in Hispanic youth residing in a high ultraviolet light environment.
    Pediatr Dermatol 2018 Jan 21;35(1):e52-e54. Epub 2017 Nov 21.
    Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
    Although rates of late-stage melanoma are rising in Hispanics, particularly those living in high ultraviolet light environments, little is known about the prevalence of sun protective behaviors in Hispanic children. We analyzed baseline data including frequency of sunburn, sun protective behaviors, level of U.S. Read More

    Patients with Spitz naevi in the Greek population: Epidemiologic, Clinical and Histopathological characteristics.
    J Eur Acad Dermatol Venereol 2017 Nov 17. Epub 2017 Nov 17.
    1st University Department of Dermatology - Venereology, "Andreas Sygros" Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
    Background: Spitz naevi may present with clinical and histopathological atypical features that do not affect patient prognosis but may become worrisome for patients ≥40 years presenting with newly appearing SN.

    Objective: Patient characteristics and sun behaviour patterns were investigated in correlation with age. SN characteristics and histopathological attributes were also investigated in correlation with age. Read More

    Development and Evaluation of Lipid Nanoparticles Containing Natural Botanical Oil for Sun Protection: Characterization and in vitro and in vivo Human Skin Permeation and Toxicity.
    Skin Pharmacol Physiol 2018 4;31(1):1-9. Epub 2017 Nov 4.
    Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Departamento de Ciências Farmacêuticas, Universidade Federal de São Paulo, UNIFESP-Diadema, São Paulo, Brazil.
    The use of sunscreen products is widely promoted by schools, government agencies, and health-related organizations to minimize sunburn and skin damage. In this study, we developed stable solid lipid nanoparticles (SLNs) containing the chemical UV filter octyl methoxycinnamate (OMC). In parallel, we produced similar stable SLNs in which 20% of the OMC content was replaced by the botanical urucum oil. Read More

    Consumption of ellagic acid and dihydromyricetin synergistically protects against UV-B induced photoaging, possibly by activating both TGF-β1 and wnt signaling pathways.
    J Photochem Photobiol B 2018 Jan 7;178:92-100. Epub 2017 Nov 7.
    Dept. of Food & Nutrition, Obesity/Diabetes Center, Hoseo University, Asan, South Korea. Electronic address:
    Ellagic acid (EGA) and dihydromyricetin (DHM) are both found in fruits and vegetables are used for anti-aging treatment for the skin. The anti-photoaging efficacy of EGA and DHM was investigated in UV-B irradiated skin in vivo and the involvement of transforming growth factor (TGF)-β1 and wnt signaling pathways were examined in vitro. HaCaT cells were treated with either 50μM EGA, 50μM DHM or 25μM EGA+25μM DHM before 100mJ/cm UV-B exposure, and then oxidative stress and inflammation was measured. Read More

    Counseling on Sun Protection and Indoor Tanning.
    Pediatrics 2017 Dec 10;140(6). Epub 2017 Nov 10.
    Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia.
    Background: The US Preventive Services Task Force recommends clinical counseling for individuals ages 10 to 24 years to decrease skin cancer risk.

    Methods: A national, random sample of US American Academy of Pediatrics members practicing primary care in 2002 (response rate 55%) and 2015 (response rate 43%). Surveys explored attitudes and experiences regarding sun protection counseling; indoor tanning questions were added in 2015. Read More

    From UV Protection to Protection in the Whole Spectral Range of the Solar Radiation: New Aspects of Sunscreen Development.
    Adv Exp Med Biol 2017 ;996:311-318
    Center of Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany.
    Sunscreens have been constantly improving in the past few years. Today, they provide an efficient protection not only in the UVB but also in the UVA spectral region of the solar radiation. Recently it could be demonstrated that 50% of all free radicals induced in the skin due to solar radiation are formed in the visible and infrared spectral region. Read More

    Ultraviolet Photobiology in Dermatology.
    Adv Exp Med Biol 2017 ;996:89-104
    Department of Dermatology, UH Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, OH, 44106, USA.
    The effects of ultraviolet radiation on human skin have been studied for years, and both its harmful and therapeutic effects are well known. Exposure to UV light can lead to sunburn, immunosuppression, skin aging, and carcinogenesis, and photoprotection is strongly advocated. However, when used under controlled conditions, UV radiation can also be helpful in the diagnosis and treatment of many skin conditions. Read More

    Ultraviolet radiation and skin cancer risk in offshore workers.
    Occup Med (Lond) 2017 Oct;67(7):569-573
    Department of Research, Cancer Registry of Norway, N-0304 Oslo, Norway.
    Background: Excess skin cancer mortality and incidence have been reported among both land-based and offshore petroleum workers. The association between skin cancer and ultraviolet radiation (UVR) exposure has not been examined in these workers, although they have long off-duty periods and high average income that may allow travelling to sunny destinations. In addition, they have access to solariums free of charge on many accommodation platforms. Read More

    Histological observation of hairless mice skin after exposure to Simulated Solar Light: Comparison between the histological findings with different methodologies and 3R principle correlations.
    Burns 2018 Mar 9;44(2):359-369. Epub 2017 Oct 9.
    Laboratório de Microbiologia e Avaliação Genotóxica, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Albino hairless mouse (AHM) has been used as a biological model in photodermatology. However, the experimental landscape is diverse to follow and need particular attention.

    Purpose: Irradiation parameters were investigated for the development of a protocol to assess alterations in the AHM skin using Simulated Solar Light (SSL). Read More

    Managing actinic keratosis in primary care.
    Practitioner 2016 10;260(1797):25-9
    Actinic, or solar, keratosis is caused by chronic ultraviolet-induced damage to the epidermis. In the UK, 15-23% of individuals have actinic keratosis lesions. Risk factors include: advanced age; male gender; cumulative sun exposure or phototherapy; Fitzpatrick skin phototypes I-II; long-term immuno-suppression and genetic syndromes e. Read More

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