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    Prevalence of sun protection behaviors in Hispanic youth residing in a high ultraviolet light environment.
    Pediatr Dermatol 2017 Nov 21. Epub 2017 Nov 21.
    Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
    Although rates of late-stage melanoma are rising in Hispanics, particularly those living in high ultraviolet light environments, little is known about the prevalence of sun protective behaviors in Hispanic children. We analyzed baseline data including frequency of sunburn, sun protective behaviors, level of U.S. Read More

    Patients with Spitz nevi in the Greek population: Epidemiologic, Clinical, and histopathological characteristics.
    J Eur Acad Dermatol Venereol 2017 Nov 17. Epub 2017 Nov 17.
    1st University, Department of Dermatology - Venereology, "Andreas Sygros" Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
    Background: Spitz nevi may present with clinical and histopathological atypical features that do not affect patient prognosis, but may become worrisome for patients ≥40 years presenting with newly appearing SN.

    Objective: Patient characteristics and sun behavior patterns were investigated in correlation with age. SN characteristics and histopathological attributes were also investigated in correlation with age. Read More

    Development and Evaluation of Lipid Nanoparticles Containing Natural Botanical Oil for Sun Protection: Characterization and in vitro and in vivo Human Skin Permeation and Toxicity.
    Skin Pharmacol Physiol 2017 Nov 4;31(1):1-9. Epub 2017 Nov 4.
    Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Departamento de Ciências Farmacêuticas, Universidade Federal de São Paulo, UNIFESP-Diadema, São Paulo, Brazil.
    The use of sunscreen products is widely promoted by schools, government agencies, and health-related organizations to minimize sunburn and skin damage. In this study, we developed stable solid lipid nanoparticles (SLNs) containing the chemical UV filter octyl methoxycinnamate (OMC). In parallel, we produced similar stable SLNs in which 20% of the OMC content was replaced by the botanical urucum oil. Read More

    Consumption of ellagic acid and dihydromyricetin synergistically protects against UV-B induced photoaging, possibly by activating both TGF-β1 and wnt signaling pathways.
    J Photochem Photobiol B 2017 Nov 7;178:92-100. Epub 2017 Nov 7.
    Dept. of Food & Nutrition, Obesity/Diabetes Center, Hoseo University, Asan, South Korea. Electronic address:
    Ellagic acid (EGA) and dihydromyricetin (DHM) are both found in fruits and vegetables are used for anti-aging treatment for the skin. The anti-photoaging efficacy of EGA and DHM was investigated in UV-B irradiated skin in vivo and the involvement of transforming growth factor (TGF)-β1 and wnt signaling pathways were examined in vitro. HaCaT cells were treated with either 50μM EGA, 50μM DHM or 25μM EGA+25μM DHM before 100mJ/cm(2) UV-B exposure, and then oxidative stress and inflammation was measured. Read More

    Ultraviolet Photobiology in Dermatology.
    Adv Exp Med Biol 2017 ;996:89-104
    Department of Dermatology, UH Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, OH, 44106, USA.
    The effects of ultraviolet radiation on human skin have been studied for years, and both its harmful and therapeutic effects are well known. Exposure to UV light can lead to sunburn, immunosuppression, skin aging, and carcinogenesis, and photoprotection is strongly advocated. However, when used under controlled conditions, UV radiation can also be helpful in the diagnosis and treatment of many skin conditions. Read More

    Ultraviolet radiation and skin cancer risk in offshore workers.
    Occup Med (Lond) 2017 Oct;67(7):569-573
    Department of Research, Cancer Registry of Norway, N-0304 Oslo, Norway.
    Background: Excess skin cancer mortality and incidence have been reported among both land-based and offshore petroleum workers. The association between skin cancer and ultraviolet radiation (UVR) exposure has not been examined in these workers, although they have long off-duty periods and high average income that may allow travelling to sunny destinations. In addition, they have access to solariums free of charge on many accommodation platforms. Read More

    Histological observation of hairless mice skin after exposure to Simulated Solar Light: Comparison between the histological findings with different methodologies and 3R principle correlations.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Laboratório de Microbiologia e Avaliação Genotóxica, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Albino hairless mouse (AHM) has been used as a biological model in photodermatology. However, the experimental landscape is diverse to follow and need particular attention.

    Purpose: Irradiation parameters were investigated for the development of a protocol to assess alterations in the AHM skin using Simulated Solar Light (SSL). Read More

    Managing actinic keratosis in primary care.
    Practitioner 2016 10;260(1797):25-9
    Actinic, or solar, keratosis is caused by chronic ultraviolet-induced damage to the epidermis. In the UK, 15-23% of individuals have actinic keratosis lesions. Risk factors include: advanced age; male gender; cumulative sun exposure or phototherapy; Fitzpatrick skin phototypes I-II; long-term immuno-suppression and genetic syndromes e. Read More

    Prevalence and predictors of sunburn among beachgoers.
    Photodermatol Photoimmunol Photomed 2017 Oct 4. Epub 2017 Oct 4.
    Cátedra de Dermatología, Universidad de Málaga, Málaga, Spain.
    Background: Painful sunburns at any age are one of the main risk factors for skin cancer.

    Objectives: To determine the prevalence and predictors of sunburn among beachgoers.

    Methods: A cross-sectional health survey was conducted at the beach during the summer. Read More

    Vitamin D Prevents Sunburn: Tips for the Summer?
    J Invest Dermatol 2017 Oct;137(10):2045-2047
    Department of Medicine, VA Medical Center, San Francisco, California, USA; and University of California San Francisco, San Francisco, California, USA. Electronic address:
    In the article by Scott et al, a high dose of vitamin D attenuated the inflammatory response to UV radiation in a small group of normal volunteers. The best results were in those subjects who had the greatest increase in circulating 25hydroxyvitamin D. Using microarray analyses these subjects showed a reduction in the expression of inflammatory markers with an increase in markers of skin barrier repair. Read More

    Medical and psychological problems faced by young Australian gap year travellers.
    J Travel Med 2017 Sep;24(5)
    Travel Medicine Alliance Clinics, 47 Adelaide Street, 47 Adelaide Street, Brisbane, QLD 4000, Australia.
    Background: Gap year travellers can potentially be exposed to many infectious diseases and other travel-related health problems including injuries and psychological problems. Currently, there is little information on health and wellbeing of this particular group of travellers.

    Methods: Participants were recruited from an organization that specialized in organising international gap year placements. Read More

    Cutaneous malignant melanoma incidences analyzed worldwide by sex, age, and skin type over personal Ultraviolet-B dose shows no role for sunburn but implies one for Vitamin D3.
    Dermatoendocrinol 2017 14;9(1):e1267077. Epub 2016 Dec 14.
    Marquette University, Department of Mathematics, Statistics, and Computer Science, Milwaukee, WI, USA.
    Because the incidence of cutaneous malignant melanoma (CMM) was reported to increase with increasing terrestrial UVR (290-400 nm) doses in the US back in 1975 and a recent publication showed no association exists with UVR exposure at all, we set out to fully elucidate the role of UVR in CMM. To achieve this goal, we analyzed the CMM incidences over latitude and estimated the average personal UVR dose in the US and numerous countries (> 50) on 5 continents around the world. Using data from the International Agency for Research on Cancer in 2005, we performed worldwide analysis of CMM over UVR dose by sex, age group (0-14, 15-29, 30-49, 50-69, 70-85+) and Fitzpatrick skin types I-VI. Read More

    An open-label clinical trial assessing the efficacy and safety of Bend Skincare Anti-Aging Formula on minimal erythema dose in skin.
    Photodermatol Photoimmunol Photomed 2017 Sep 8. Epub 2017 Sep 8.
    Bend Beauty Inc., Halifax, NS, Canada.
    Background/purpose: Sunburn and other health risks associated with excess sun exposure place huge economic burdens on societies, and create discomfort and disease within susceptible individuals. Oral supplements that reduce sunburn may be advantageous. This study evaluated the safety and efficacy of Bend Skincare Anti-Aging Formula to ameliorate sunburn induced with a solar simulator. Read More

    Safety of antimalarial medications for use while scuba diving in malaria Endemic Regions.
    Trop Dis Travel Med Vaccines 2016 11;2:23. Epub 2016 Oct 11.
    Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
    Background: Recreational diving occurs annually in areas of the world where malaria is endemic. The safety and efficacy of antimalarials for travelers in a hyperbaric environment is unknown. Of particular concern would be medications with adverse effects that could either mimic diving related illnesses such as barotrauma, decompression sickness (DCS) and gas toxicities, or increase the risk for such illnesses. Read More

    CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.
    Proc Natl Acad Sci U S A 2017 Sep 6;114(38):E8035-E8044. Epub 2017 Sep 6.
    The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
    Casein kinase 1α (CK1α), a component of the β-catenin destruction complex, is a critical regulator of Wnt signaling; its ablation induces both Wnt and p53 activation. To characterize the role of CK1α (encoded by Csnk1a1) in skin physiology, we crossed mice harboring floxed Csnk1a1 with mice expressing K14-Cre-ER(T2) to generate mice in which tamoxifen induces the deletion of Csnk1a1 exclusively in keratinocytes [single-knockout (SKO) mice]. As expected, CK1α loss was accompanied by β-catenin and p53 stabilization, with the preferential induction of p53 target genes, but phenotypically most striking was hyperpigmentation of the skin, importantly without tumorigenesis, for at least 9 mo after Csnk1a1 ablation. Read More

    Sunburn and ambient temperature.
    Br J Dermatol 2017 Sep 2. Epub 2017 Sep 2.
    Newcastle University - Dermatological Sciences, Newcastle, NE2 4HH, United Kingdom.
    On days during the summer months when high temperatures are expected, weather forecasters frequently warn about the dangers of UV and high UV indices. It is not surprising, therefore, that it is a common belief that high ambient air temperatures are a major risk factor for burning. Although the UV index is generally higher on cloudless, hot days compared with cloudy, cool days, reliance should not be placed on ambient temperature alone as a guide to the need for sun protection. Read More

    Determinants of Sunburn and Sun Protection of Agricultural Workers During Occupational and Recreational Activities.
    J Occup Environ Med 2017 Nov;59(11):1089-1094
    University Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland (Ms Backes, Dr Bulliard); Institute for Work and Health (IST), University of Lausanne and Geneva, Lausanne, Switzerland (Ms Backes, Mr Milon, Dr Vernez); International Prevention Research Institute, Lyon, France (Ms Koechlin); and University of Strathclyde Institute for Global Public Health at iPRI, International Prevention Research Institute, Lyon, France (Ms Koechlin).
    Objective: The aim of this study was to identify determinants of occupational sunburn in agricultural workers and assess their occupational and recreational sun protection habits.

    Methods: Specific surveys of agricultural workers in Switzerland and France were conducted (N = 1538). Multivariate logistic regressions identified occupational sunburn determinants. Read More

    Topical application of Nexrutine inhibits ultraviolet B-induced cutaneous inflammatory responses in SKH-1 hairless mouse.
    Photodermatol Photoimmunol Photomed 2017 Aug 30. Epub 2017 Aug 30.
    Environmental Carcinogenesis Laboratory, Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
    Background: Ultraviolet B (UVB) radiation is the major contributor to skin inflammation which leads to the development of skin cancer. Hence, in this study, we studied the effect of Nexrutine (NX) on UVB-induced cutaneous inflammation and its mediators.

    Methods: Ultraviolet absorption spectra of NX were measured by spectrophotometer. Read More

    Sun protection by umbrellas and walls.
    Photochem Photobiol Sci 2017 Oct;16(10):1537-1545
    Johnson and Johnson Consumer Inc., Skillman, NJ 08558, USA.
    Solar protection is an important public health issue because solar UV exposure can cause acute and chronic damage to the skin. Seeking shade is a convenient and commonly practiced sun avoidance measure. Shade works by physically shielding the skin from direct UV rays; however UV rays can also reach the skin from other angles. Read More

    Oxidized Polymeric Phenolics: Could They Be Considered Photoprotectors?
    J Agric Food Chem 2017 Sep 28;65(36):7843-7846. Epub 2017 Aug 28.
    Dipartimento di Scienze Agrarie e Ambientali (DISAA), Università degli Studi di Milano , via Celoria 2, 20133 Milano, Italy.
    Photooxidative sunburn is the consequence of photosystem overexcitations. It results in tissue color changes as a result of chlorophyll degradation and accumulation of oxidized polymeric phenolics (OPPs), resulting from scavenging of reactive oxygen species (ROS). From a productive point of view, OPPs should be considered as damages, decreasing the economical and esthetical values of plants and crops. Read More

    Juvenile melanomas: Western Australian Melanoma Advisory Service experience.
    Australas J Dermatol 2017 Nov 15;58(4):299-303. Epub 2017 Aug 15.
    St John of God Hospital, Perth, Western Australia, Australia.
    Background/objectives: Juvenile melanoma (before 20 years of age) is a rare condition with poorly defined risk factors. We describe features of juvenile melanoma in Western Australia over the last two decades.

    Method: A retrospective review of juvenile melanomas was conducted from prospectively maintained databases, reviewed for patients' characteristics, clinical information, histology, treatment, recurrence and survival data. Read More

    The Possible Pre- and Post-UVA Radiation Protective Effect of Amaranth Oil on Human Skin Fibroblast Cells.
    Pharmacogn Mag 2017 Jul 11;13(Suppl 2):S339-S343. Epub 2017 Jul 11.
    Department of Organic Chemistry, The Faculty of Pharmacy with the Division of Medical Analytics, Medical University of Bialystok, Białystok, Poland.
    Background: The health effects of Amaranth Oil (AO) are attributed to its specific chemical composition. That makes it an outstanding natural product for the prevention and treatment of ultraviolet (UV) irradiation-related pathologies such as sunburn, photoaging, photoimmunosuppression, and photocarcinogenesis. Most of the studies are taken on animal model, and there is a lack of research on the endogenous effect of AO on fibroblast level, where UVA takes it harmful place. Read More

    The untold story of the scorching sun-A wake up call for sun protection.
    Burns 2017 Aug 4. Epub 2017 Aug 4.
    Burns Unit, The Mid Yorkshire Hospitals NHS Trust, Pinderfields General Hospital, Aberford Rd, Wakefield WF1 4DG, UK. Electronic address:
    Despite extensive warnings from health authorities regarding the dangers of direct sunlight exposure, most people still turn to sun bathing to get a golden tan. Unfortunately, that pleasant tan appearance is often lost because of over exposure to sunlight, resulting in painful red sunburns. In this paper we are reporting a case with significant sunburn injuries that required hospitalization and treatment in a burn center. Read More

    Iris Freckles a Potential Biomarker for Chronic Sun Damage.
    Invest Ophthalmol Vis Sci 2017 May;58(6):BIO174-BIO179
    Department of Dermatology, Medical University of Graz, Graz, Austria.
    Purpose: To investigate the role of sunlight exposure in iris freckles formation.

    Methods: We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure. Read More

    Associations between sun exposure and other lifestyle variables in Swedish women.
    Cancer Causes Control 2017 Jul 14. Epub 2017 Jul 14.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Purpose: Sun exposure is associated with risk of several chronic diseases including cancer. The study aim is to investigate whether sun behaviors are related to other lifestyle risk factors of cancer.

    Methods: We analyzed data collected in 2003-2004 by self-completed questionnaire from 34,402 Swedish women aged 40-61 years, who comprised 70% of a cohort of originally recruited from a population registry in 1991-1992 (n = 49,259). Read More

    Conventional sunscreen application does not lead to sufficient body coverage.
    Int J Cosmet Sci 2017 Oct 11;39(5):550-555. Epub 2017 Aug 11.
    Research & Development, Beiersdorf AG, Hamburg, Germany.
    Objective: This study aimed to assess sunscreen application habits and relative body coverage after single whole body application.

    Methods: Fifty-two healthy volunteers were asked to use the test product once, following their usual sunscreen application routine. Standardized UV photographs, which were evaluated by Image Analysis, were conducted before and immediately after product application to evaluate relative body coverage. Read More

    Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations.
    Sci Rep 2017 Jul 11;7(1):5106. Epub 2017 Jul 11.
    Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
    Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin cancer. Read More

    Diagnosis of Xeroderma pigmentosum variant in a young patient with two novel mutations in the POLH gene.
    Am J Med Genet A 2017 Sep 8;173(9):2511-2516. Epub 2017 Jul 8.
    Laboratory of Genetic Instability and Oncogenesis, UMR8200 CNRS, Gustave Roussy, Université Paris-Sud, Villejuif, France.
    We describe the characterization of Xeroderma Pigmentosum variant (XPV) in a young Caucasian patient with phototype I, who exhibited a high sensitivity to sunburn and multiple cutaneous tumors at the age of 15 years. Two novel mutations in the POLH gene, which encodes the translesion DNA polymerase η, with loss of function due to two independent exon skippings, are reported to be associated as a compound heterozygous state in the patient. Western blot analysis performed on proteins from dermal fibroblasts derived from the patient and analysis of the mutation spectrum on immunoglobulin genes produced during the somatic hypermutation process in his memory B cells, show the total absence of translesion polymerase η activity in the patient. Read More

    Sun Exposure and Psychotic Experiences.
    Front Psychiatry 2017 19;8:107. Epub 2017 Jun 19.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Objective: Sun exposure is considered the single most important source of vitamin D. Vitamin D deficiency has been suggested to play a role in the etiology of psychotic disorders. The aim of the present study was to evaluate the association between sun exposure and psychotic experiences (PEs) in a general population sample of Swedish women. Read More

    Aware, motivated and striving for a 'safe tan': an exploratory mixed-method study of sun-protection during holidays.
    Health Psychol Behav Med 2017 5;5(1):276-298. Epub 2017 Jun 5.
    Institute of Health and Society, Medical Faculty, Newcastle University, Newcastle upon Tyne, UK.
    Background: This article presents an exploratory study, aiming to explore the correspondence between knowledge, motivation and sun-protection practices during holidays. Methods: Seventeen participants aged 21-62 years old, recruited from community settings took part in individual face-to-face semi-structured interviews, completed sun sensitivity questions and an objective assessment of sunscreen use. Holidaymakers' knowledge about sun-safe messages, intentions and perceptions of barriers and facilitators for sun-protection were assessed. Read More

    Total body skin examination adherence among young adults with an increased risk for skin cancer.
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    Department of Public Health, University of North Florida, Jacksonville, Florida.
    Although ultraviolent radiation exposure and skin cancer rates are rising in the US, there is not a consistent national message calling for routine total body skin examinations (TBSE) by a healthcare provider. This pilot study examined TBSE rates among adults at an increased risk for skin cancer (history of sunburn, indoor tanning use, excessive UV exposure, poor sunscreen use). Overall skin cancer prevention behaviors were insufficient among respondents (n=953) and only a quarter of respondents considered at an increased risk for skin cancer reported a TBSE. Read More

    Systematic and Iterative Development of a Smartphone App to Promote Sun-Protection Among Holidaymakers: Design of a Prototype and Results of Usability and Acceptability Testing.
    JMIR Res Protoc 2017 Jun 12;6(6):e112. Epub 2017 Jun 12.
    Institute of Health & Society, Newcastle University, Newcastle Upon Tyne, United Kingdom.
    Background: Sunburn and intermittent exposure to ultraviolet rays are risk factors for melanoma. Sunburn is a common experience during holidays, making tourism settings of particular interest for skin cancer prevention. Holidaymakers are a volatile populations found at different locations, which may make them difficult to reach. Read More

    Intentional outdoor tanning in the United States: Results from the 2015 Summer ConsumerStyles survey.
    Prev Med 2017 Aug 7;101:137-141. Epub 2017 Jun 7.
    Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
    There is limited literature about adults in the United States who usually or always spend time outdoors for the purpose of developing a tan, defined as intentional outdoor tanning. Using data from the 2015 Summer ConsumerStyles, an online cross-sectional survey weighted to the US adult population (n=4,127), we performed unadjusted and adjusted multivariable logistic regressions to examine the associations between demographic characteristics, behaviors, and belief factors related to skin cancer risk and intentional outdoor tanning. Nearly 10% of the study population intentionally tanned outdoors. Read More

    Oral Vitamin D Rapidly Attenuates Inflammation from Sunburn: An Interventional Study.
    J Invest Dermatol 2017 Oct 30;137(10):2078-2086. Epub 2017 May 30.
    Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA; Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Electronic address:
    The diverse immunomodulatory effects of vitamin D are increasingly being recognized. However, the ability of oral vitamin D to modulate acute inflammation in vivo has not been established in humans. In a double-blinded, placebo-controlled interventional trial, 20 healthy adults were randomized to receive either placebo or a high dose of vitamin D3 (cholecalciferol) one hour after experimental sunburn induced by an erythemogenic dose of UVR. Read More

    Prevalence of sun-protective behaviour and intentional sun tanning in German adolescents and adults: results of a nationwide telephone survey.
    J Eur Acad Dermatol Venereol 2017 Jun 2. Epub 2017 Jun 2.
    Mannheim Institute of Public Health, Social and Preventive Medicine, Heidelberg University, Mannheim, Germany.
    Background: The incidence rate of melanoma in the Caucasian population is rising worldwide. One of the major environmental risk factors for melanoma is the exposure to ultraviolet (UV) radiation. To prevent skin damage caused by UV exposure, several organizations recommend wearing protective clothing, staying in the shade, avoiding the outdoors during midday and using sunscreen. Read More

    Backyard Pool Party: Not Your Typical Sunburn.
    Pediatr Emerg Care 2017 Jun;33(6):440-442
    Department of Emergency Medicine, University of California, San Francisco-Fresno Medical Education and Research, Fresno, CA (e-mail: Department of Emergency Medicine University of California San Francisco-Fresno Medical Education and Research Fresno, CA Department of Internal Medicine, University of California, San Francisco-Fresno Medical Education and Research, Fresno, CA Department of Emergency Medicine, University of California, San Francisco-Fresno Medical Education and Research, Fresno, CA.

    Ultraviolet radiation accelerates NRas-mutant melanomagenesis: A cooperative effect blocked by sunscreen.
    Pigment Cell Melanoma Res 2017 Sep 4;30(5):477-487. Epub 2017 Jul 4.
    Department of Cancer Biology and Genetics, Biomedical Research Tower, The Ohio State University, Columbus, OH, USA.
    To mitigate melanoma risk, sunscreen use is widely advocated; yet, the ability of sunscreens to prevent melanoma remains controversial. Here, we test the tenet that sunscreens limit melanoma risk by blocking ultraviolet radiation (UV)-induced DNA damage using murine models that recapitulate the genetics and spontaneous evolution of human melanoma. We find that a single, non-erythematous dose of UV dramatically accelerates melanoma onset and increases tumor multiplicity in mice carrying an endogenous, melanocyte-specific NRas(61R) allele. Read More

    Knowledge deficit, attitude and behavior scales association to objective measures of sun exposure and sunburn in a Danish population based sample.
    PLoS One 2017 25;12(5):e0178190. Epub 2017 May 25.
    Department of Prevention and Information, Danish Cancer Society, Strandboulevarden 49, Copenhagen Ø, Denmark.
    The objective of this study was to develop new scales measuring knowledge and attitude about UVR and sun related behavior, and to examine their association to sun related behavior objectively measured by personal dosimetry. During May-August 2013, 664 Danes wore a personal electronic UV-dosimeter for one week that measured their UVR exposure. Afterwards, they answered a questionnaire on sun-related items. Read More

    Choctaw Nation Youth Sun Exposure Survey.
    Prev Med Rep 2017 Sep 28;7:7-10. Epub 2017 Apr 28.
    Stephenson Cancer Center, Department of Family Medicine, OUHSC, 655 Research Parkway, Room 448, Oklahoma City, OK 73104, United States.
    The incidence of skin cancer is rising among American Indians (AI) but the prevalence of harmful ultraviolet light (UVL) exposures among AI youth is unknown. In 2013, UVL exposures, protective behaviors, and attitudes toward tanning were assessed among 129 AI and Non-Hispanic (NHW) students in grades 8-12 in Southeastern Oklahoma. Sunburn was reported by more than half the AI students and most of the NHW students. Read More

    Pterostilbene protects against UVB-induced photo-damage through a phosphatidylinositol-3-kinase-dependent Nrf2/ARE pathway in human keratinocytes.
    Redox Rep 2017 Nov 22;22(6):501-507. Epub 2017 May 22.
    a Guangzhou Institute of Dermatology , Guangzhou , China.
    Objective: Ultraviolet B (UVB) irradiation is the initial etiological factor for various skin disorders, including erythema, sunburn, photoaging, and photocarcinogenesis. Pterostilbene (Pter) displayed remarkable antioxidant, anti-inflammatory, and anticarcinogenic activities. This study aimed to investigate the effective mechanism of Pter against UVB-induced photodamage in immortalized human keratinocytes. Read More

    CXCL1 Inhibition Regulates UVB-Induced Skin Inflammation and Tumorigenesis in Xpa-Deficient Mice.
    J Invest Dermatol 2017 Sep 17;137(9):1975-1983. Epub 2017 May 17.
    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address:
    Xeroderma pigmentosum complementation group A is a hereditary disease characterized by early onset of skin cancers and freckle-like pigmented maculae in sun-exposed sites. Although the etiology of the predisposition to UVR-induced skin tumors in xeroderma pigmentosum complementation group A is well investigated as a repair deficiency in UVR-induced DNA damage, the mechanism of exaggerated sunburn in patients with xeroderma pigmentosum complementation group A and whether UVR-induced inflammation relates to a skin tumor-prone phenotype remains to be elucidated. Using gene profiling of xeroderma pigmentosum complementation group A model mice, Xpa-deficient mice, we found that expression of CXCL1 in the skin and blood of Xpa-deficient mice increased significantly after UVB exposure over even a limited area compared with that of wild-type mice. Read More

    Parent and Child Characteristics Associated with Child Sunburn and Sun Protection Among U.S. Hispanics.
    Pediatr Dermatol 2017 May;34(3):315-321
    Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, New Jersey.
    Background/objectives: Skin cancer incidence has been increasing in U.S. Hispanics over several decades and the postdiagnosis outcomes are worse for Hispanics than for non-Hispanic whites. Read More

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