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    Ultraviolet radiation accelerates NRas-mutant melanomagenesis: a cooperative effect blocked by sunscreen.
    Pigment Cell Melanoma Res 2017 May 24. Epub 2017 May 24.
    Department of Cancer Biology and Genetics, The Ohio State University, Biomedical Research Tower, 460 W. 12th Avenue, Columbus, OH 43210.
    To mitigate melanoma risk, sunscreen use is widely advocated; yet, the ability of sunscreens to prevent melanoma remains controversial. Here, we test the tenet that sunscreens limit melanoma risk by blocking ultraviolet radiation (UV)-induced DNA damage using murine models that recapitulate the genetics and spontaneous evolution of human melanoma. We find that a single, non-erythematous dose of UV dramatically accelerates melanoma onset and increases tumor multiplicity in mice carrying an endogenous, melanocyte-specific NRas(61R) allele. Read More

    Knowledge deficit, attitude and behavior scales association to objective measures of sun exposure and sunburn in a Danish population based sample.
    PLoS One 2017 25;12(5):e0178190. Epub 2017 May 25.
    Department of Prevention and Information, Danish Cancer Society, Strandboulevarden 49, Copenhagen Ø, Denmark.
    The objective of this study was to develop new scales measuring knowledge and attitude about UVR and sun related behavior, and to examine their association to sun related behavior objectively measured by personal dosimetry. During May-August 2013, 664 Danes wore a personal electronic UV-dosimeter for one week that measured their UVR exposure. Afterwards, they answered a questionnaire on sun-related items. Read More

    Choctaw Nation Youth Sun Exposure Survey.
    Prev Med Rep 2017 Sep 28;7:7-10. Epub 2017 Apr 28.
    Stephenson Cancer Center, Department of Family Medicine, OUHSC, 655 Research Parkway, Room 448, Oklahoma City, OK 73104, United States.
    The incidence of skin cancer is rising among American Indians (AI) but the prevalence of harmful ultraviolet light (UVL) exposures among AI youth is unknown. In 2013, UVL exposures, protective behaviors, and attitudes toward tanning were assessed among 129 AI and Non-Hispanic (NHW) students in grades 8-12 in Southeastern Oklahoma. Sunburn was reported by more than half the AI students and most of the NHW students. Read More

    Pterostilbene protects against UVB-induced photo-damage through a phosphatidylinositol-3-kinase-dependent Nrf2/ARE pathway in human keratinocytes.
    Redox Rep 2017 May 22:1-7. Epub 2017 May 22.
    a Guangzhou Institute of Dermatology , Guangzhou , China.
    Objective: Ultraviolet B (UVB) irradiation is the initial etiological factor for various skin disorders, including erythema, sunburn, photoaging, and photocarcinogenesis. Pterostilbene (Pter) displayed remarkable antioxidant, anti-inflammatory, and anticarcinogenic activities. This study aimed to investigate the effective mechanism of Pter against UVB-induced photodamage in immortalized human keratinocytes. Read More

    CXCL1 inhibition regulates UVB-induced skin inflammation and tumorigenesis in Xpa-deficient mice.
    J Invest Dermatol 2017 May 17. Epub 2017 May 17.
    Division of Dermatology, Department of Internal Related, Graduate School of Medicine, Kobe University, Kobe, Japan. Electronic address:
    Xeroderma pigmentosum complementation group A (XP-A) is a hereditary disease characterized by early onset of skin cancers and freckles-like pigmented maculae in the sun-exposed sites. Although etiology of predisposition to UV-induced skin tumors in XP-A is well investigated as a repair deficiency in UV-induced DNA damage, the mechanism of exaggerated sunburn in patients with XP-A and whether UV-induced inflammation relates to skin tumor-prone phenotype remains to be elucidated. Using gene profiling of XP-A model mice, Xpa-deficient mice, we found that expression of CXCL1 in the skin and blood levels of in Xpa-deficient mice increased significantly after UVB exposure at an even a limited area in comparison to those of wild-type mice. Read More

    Parent and Child Characteristics Associated with Child Sunburn and Sun Protection Among U.S. Hispanics.
    Pediatr Dermatol 2017 May;34(3):315-321
    Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, New Jersey.
    Background/objectives: Skin cancer incidence has been increasing in U.S. Hispanics over several decades and the postdiagnosis outcomes are worse for Hispanics than for non-Hispanic whites. Read More

    Sun exposure, sun protection and sunburn among Canadian adults.
    Health Rep 2017 May;28(5):12-19
    Environment and Climate Change Canada, Toronto, Ontario.
    Background: Ultraviolet radiation (UVR) exposure and a history of sunburn are important risk factors for skin cancer. Sunburn is more common among men, younger age groups, and people in higher income households. Sun protection measures also vary by sex, age, and socioeconomic characteristics. Read More

    The risk of melanoma associated with ambient summer ultraviolet radiation.
    Health Rep 2017 May;28(5):3-11
    Health Analysis Division, Statistics Canada, Ottawa, Ontario.
    Background: Depletion of the ozone layer has meant that ambient ultraviolet radiation (UVR) has increased in recent decades. At the same time, the incidence of skin cancers, including melanoma, has risen. The relatively few large-scale studies that linked ambient UVR to melanoma found a trend toward rising incidence closer to the equator, where UVR estimates are highest. Read More

    Recognizing Latinos' Range of Skin Pigment and Phototypes to Enhance Skin Cancer Prevention.
    Pigment Cell Melanoma Res 2017 May 15. Epub 2017 May 15.
    Evan Pugh University Professor of Anthropology at The Pennsylvania State University, Stellenbosch Institute for Advanced Study, 403 D Carpenter Bldg, University Park, PA 16802-6900.
    Latinos in the United States may have the mistaken assumption that their natural pigmentation protects them from developing skin cancer that, effectively, serves as a barrier to Latinos receiving education in primary and secondary prevention of skin cancer. Latino adults of Mexican or Puerto Rican heritage attending community health fairs in the greater Chicago area responded to a culturally informed and sensitive measure for sunburn and tan, which was previously adapted to capture skin irritation with tenderness from the sun occurring in darker skin types (n=350). By self-reported responses and spectrophotometry assessment of constitutive pigmentation, adapted Fitzpatrick skin types (FST) ranged from skin type I to IV in the Mexican-American participants and from II to V in the Puerto Rican participants. Read More

    Uveal Melanoma Risk Factors: A Systematic Review of Meta-Analyses.
    Curr Eye Res 2017 May 11:1-9. Epub 2017 May 11.
    a The Henry C. Witelson Ocular Pathology Laboratory , McGill University , Montreal , QC , Canada.
    Purpose: There is currently no clinical risk-assessment tool allowing identification of patients at risk for developing uveal melanoma (UM) who might benefit from regular screening. As a first step toward the elaboration of such a tool, we systematically reviewed UM risk factors already established by meta-analysis.

    Methods: Two reviewers independently screened Pubmed, Medline, Embase, and Web of Science from their respective inception dates until July 2016 using a combination of keywords and MeSH terms. Read More

    Unintended Sunburn: A Potential Target for Sun Protection Messages.
    J Skin Cancer 2017 3;2017:6902942. Epub 2017 Apr 3.
    Department of Preventive & Social Medicine, University of Otago School of Medicine, Dunedin, New Zealand.
    New Zealand (NZ) has the highest melanoma incidence rate in the world. Primary prevention efforts focus on reducing sunburn incidence and increasing sun protective practices in the population. However, sunburn from excessive ultraviolet radiation (UVR) remains common. Read More

    Theoretical insights on flavanones as antioxidants and UV filters: A TDDFT and NLMO study.
    J Photochem Photobiol B 2017 Apr 20;170:286-294. Epub 2017 Apr 20.
    Department of Chemistry, University of Calicut, Malappuram 673635, India. Electronic address:
    UV radiations can cause several irritations to the skin like sunburn, photo aging and even skin cancer. Sunscreens are widely used to protect the skin against these harmful radiations. One of the ingredients present in these sunscreens are organic molecules capable of absorbing these harmful radiations. Read More

    Conjunctival ultraviolet autofluorescence as a measure of past sun exposure in children.
    Cancer Epidemiol Biomarkers Prev 2017 Apr 26. Epub 2017 Apr 26.
    Murdoch Children's Research Institute.
    Background: Conjunctival ultraviolet autofluorescence (CUVAF) area detected from UVAF photographs is a recently developed potential marker for past sun exposure but its relationship with sun-related factors have not been fully investigated.

    Methods: The study included 339 ethnically diverse and healthy children aged 5-15 years in Melbourne, Australia. Data were collected by questionnaire and examination at school. Read More

    Xeroderma pigmentosum complementation group F: A rare cause of cerebellar ataxia with chorea.
    J Neurol Sci 2017 May 16;376:198-201. Epub 2017 Mar 16.
    Department of Neurology, Strasbourg University Hospital, Strasbourg, France; FMTS, Medecine Faculty, Strasbourg, France.
    The complementation group F of Xeroderma pigmentosum (XP-F) is rare in the Caucasian population, and usually devoid of neurological symptoms. We report two cases, both Caucasian, who exhibited progressive cerebellar ataxia, chorea, a mild subcortical frontal cognitive impairment, and in one case severe polyneuropathy. Brain MRI demonstrated cerebellar (2/2) and cortical (1/2) atrophy. Read More

    Oral intake of Boesenbergia pandurata extract improves skin hydration, gloss, and wrinkling: A randomized, double-blind, and placebo-controlled study.
    J Cosmet Dermatol 2017 Apr 18. Epub 2017 Apr 18.
    Department of Biotechnology, Yonsei University, Seoul, Korea.
    Background: Photoaging is a severe skin damage that occurs as a result of exposure to external elements, primarily ultraviolet (UV) irradiation. Chronically, UV-irradiated skin exhibits the signs of sunburn and hyperpigmentation with the destruction of connective tissues. Previously, Boesenbergia pandurata (B. Read More

    [Sun protection factor 50+ : Pro and contra].
    Hautarzt 2017 May;68(5):368-370
    Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, 80337, München, Deutschland.
    The use of sunscreens with sun protection factors beyond 50 is controversial. In order to avoid misleading the consumer, several countries have already decided not to declare SPF beyond 50 on sunscreen products. Arguments against high SPF include the following: the risk of imbalanced protection, which could increase the risk of damage caused by longer-wave ultraviolet radiation; imparting a false sense of safety, which could lead to the extension of sun exposure times; health risks from higher concentrations of filter substances; and the only marginally higher blockade provided by high SPF sunscreens. Read More

    [Light protection for xeroderma pigmentosum].
    Hautarzt 2017 May;68(5):359-363
    Universitätsklinik für Dermatologie, Franz-Josef-Strauß Allee 11, 93053, Regensburg, Deutschland.
    Xeroderma pigmentosum is a rare autosomal recessive disorder which is caused by germinal mutations responsible for the repair of ultraviolet (UV) radiation-induced DNA lesions. It is characterized by hypersensitivity to UV radiation, poikiloderma, ocular surface disease, and in some patients pronounced sunburn and neurological disease. Patients have a very high risk of developing ocular and skin cancer on exposed body sites. Read More

    Kite-surfers' sun risk in the tropics.
    J Travel Med 2017 Mar;24(2)
    Department of Dermatology, CHU de Martinique (CHUM), Martinique, French West Indies.
    A preliminary inquiry, conducted on Martinique Island, sought to determine kite-surfers' sun-protection knowledge and behaviours. Results revealed good levels of knowledge and behaviours, but very frequent sunburns (74% had at least one sunburn during the last 6 months), with particularly severe sunburns exclusively among vacationers. These results argue for the double need to focus sunburn-prevention programs on vacationers and technically adapt sun-protection means to a tropical maritime environment. Read More

    Lifestyle and physiological factors associated with facial wrinkling in men and women.
    J Invest Dermatol 2017 Apr 6. Epub 2017 Apr 6.
    Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands. Electronic address:
    Facial wrinkling is one of the most notable signs of skin aging. Men and women show different wrinkling patterns yet the lifestyle and physiological factors underlying these sex-specific patterns are relatively unknown. Here, we investigated sex-specific determinants for facial wrinkles. Read More

    Data on solar sunburning ultraviolet (UVB) radiation at an urban Mediterranean climate.
    Data Brief 2017 Apr 11;11:597-600. Epub 2017 Mar 11.
    Medical School, University of Cyprus, Nicosia, Cyprus.
    This article describes data on the intensity of ultraviolet B (UVB) radiation collected during field questionnaire-based surveys in Athens, Greece. The surveys were conducted over 11 days of July and October 2010 at three different urban, outdoor sites. A total of 1104 interviews were conducted. Read More

    The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.
    J Am Acad Dermatol 2017 Mar 21. Epub 2017 Mar 21.
    Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. Electronic address:
    Background: There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.

    Objective: This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).

    Methods: In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. Read More

    Skin cancer history, sun-related attitudes, behaviour and sunburn among renal transplant recipients versus general population.
    Australas J Dermatol 2017 Mar 23. Epub 2017 Mar 23.
    Department of Medicine (Dermatology), St Vincent's Hospital, Melbourne, Victoria, Australia.
    Background/objectives: Renal transplant recipients (RTR) have both an excessive skin cancer incidence and a high mortality rate. In Australia RTR receive extensive public education on skin cancer and many undergo further education pre/post-transplant. This study examines whether RTR have sufficiently rigorous sun protection behaviour compared with the general population. Read More

    Research on Skin Cancer-Related Behaviors and Outcomes in the NIH Grant Portfolio, 2000-2014: Skin Cancer Intervention Across the Cancer Control Continuum (SCI-3C).
    JAMA Dermatol 2017 May;153(5):398-405
    Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
    Importance: The Surgeon General's Call to Action to Prevent Skin Cancer broadly identified research gaps, but specific objectives are needed to further behavioral intervention research.

    Objective: To review National Institute of Health (NIH) grants targeting skin cancer-related behaviors and relevant outcomes.

    Design, Setting, And Participants: A portfolio analysis of the title, abstract, specific aims, and research plans of identified grant applications from 2000 to 2014 targeting skin cancer-related behaviors or testing behavioral intervention effects on cancer-relevant outcomes along the cancer continuum. Read More

    Pigmentation phenotype, photosensitivity and skin neoplasms in patients with myotonic dystrophy.
    Eur J Neurol 2017 May 20;24(5):713-718. Epub 2017 Mar 20.
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
    Background And Purpose: Recent studies have suggested a possible excess risk of skin neoplasms in patients with myotonic dystrophy (DM). Risk factors related to this observation have not been defined.

    Method: Information regarding personal history of skin tumors, pigmentation phenotype, and skin reaction to sun exposure were collected from 266 DM patients who were enrolled in the US National Institutes of Health National Registry of Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy Patients and Family Members. Read More

    Phototoxicity of Doxycycline: A Systematic Review on Clinical Manifestations, Frequency, Cofactors, and Prevention.
    Skin Pharmacol Physiol 2017 15;30(2):76-80. Epub 2017 Mar 15.
    Department of Dermatology, University Hospital Jena, Jena, Germany.
    Background: One of the most important dermatologic side effects of doxycycline is photosensitivity. As doxycycline is important for malaria prophylaxis and malaria is mainly spread in countries with high sun radiation, special attention should be paid to this adverse effect. While there are many publications on the phototoxicity of tetracyclines in general, only a few exist focusing on doxycycline. Read More

    Knowledge and attitudes of UK university students in relation to ultraviolet radiation (UVR) exposure and their sun-related behaviours: a qualitative study.
    BMJ Open 2017 Mar 13;7(3):e014388. Epub 2017 Mar 13.
    Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
    Objectives: To explore whether knowledge about the harms of ultraviolet radiation (UVR) influences UK university students' sun-related behaviours and examine in depth their attitudes towards: sun protection, natural and artificial tanning behaviours.

    Design: Qualitative methodology with 15 semistructured, individual interviews. Thematic analysis using the Framework Method with analyst triangulation and member validation. Read More

    UV adaptation: Pigmentation and protection against overexposure.
    Exp Dermatol 2017 Mar 7. Epub 2017 Mar 7.
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
    The skin is known to adapt to UV exposures, that is become less sensitive to sunburn. Reported decreases in sensitivity vary widely from well over 10-fold down to a negligible 10%. This appears to depend importantly on the UV irradiation spectrum to which the skin adapts and on the UV irradiation spectrum that is used to test the sensitivity. Read More

    In vitro skin models for the evaluation of sunscreen-based skin photoprotection: molecular methodologies and opportunities.
    Curr Med Chem 2017 Mar 3. Epub 2017 Mar 3.
    L`Oreal Research and Innovation, 1 avenue Eugène Schueller , Aulnay sous Bois 93600. France.
    Identifying and understanding the biological events that occur following ultraviolet (UV) exposure are mandatory to elucidate the biological and clinical consequences of sun exposure, and to provide efficient and adequate photoprotection strategies. The main UV-induced biological features (markers related to sunburn, cancer, photoaging immunosuppression, pigmentation), characterized in human skin in vivo, could be reproduced in adapted models of reconstructed skin in vitro, attesting their high relevance in the field of photobiology. In turn, 3D skin models were useful to discover precise biological pathways involved in UV response and were predictive of in vivo situation. Read More

    Prevalence of Indoor Tanning and Association With Sunburn Among Youth in the United States.
    JAMA Dermatol 2017 May;153(5):387-390
    Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
    Importance: Indoor tanning and sunburns, particularly during adolescence and young adulthood, increase the risk of developing skin cancer.

    Objective: To examine the trends in the prevalence of indoor tanning and the association between indoor tanning and sunburn among US high school students.

    Design, Setting, And Participants: This study pooled and examined cross-sectional data from the 2009, 2011, 2013, and 2015 national Youth Risk Behavior Survey. Read More

    Attitudes and Behaviors Related to Sun-Safety in College Students.
    J Community Health 2017 Feb 27. Epub 2017 Feb 27.
    Department of Public Health, William Paterson University, University Hall 366, Wayne, NJ, 07470, USA.
    The purpose of this study was to determine the level of sun safe behaviors, as well as to measure knowledge and attitudes toward being tan in a sample of college students. The sample was comprised of 315 college students attending a personal health course. During Fall of 2016, a survey was distributed to assess knowledge, attitudes, and behaviors of university students regarding skin cancer related behaviors. Read More

    Predictors of Sunburn Risk Among Florida Residents.
    J Am Osteopath Assoc 2017 Mar;117(3):150-157
    Context: The incidence of skin cancer, the most common type of cancer in the United States, is increasing. Sunburn is a major modifiable risk factor for skin cancer, and its prevalence among the US population is high.

    Objectives: To identify predictors of having had a red or painful sunburn in the past 12 months among people living in Florida. Read More

    Development of Photoonycholysis with Vandetanib Therapy.
    Skin Appendage Disord 2017 Jan 3;2(3-4):146-151. Epub 2016 Nov 3.
    Department of Oncodermatology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, Toulouse, France; Department of Medical Oncology and Clinical Research, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, Toulouse, France.
    Vandetanib therapy is a novel once-daily oral multitargeted tyrosine kinase inhibitor, which is currently used in advanced or metastatic medullary thyroid cancer. Skin toxicities are among the most prevalent adverse events reported with this targeted therapy (e.g. Read More

    Marine and Other Aquatic Dermatoses.
    Indian J Dermatol 2017 Jan-Feb;62(1):66-78
    Diving School, Naval Base, Kochi, Kerala, India.
    Occupational and recreational aquatic activity predisposes our population to a wide variety of dermatoses. Sunburn, urticaria, jellyfish stings, and contact dermatitis to rubber equipment are common allergies that are encountered in the aquatic environment. Among the infections, tinea versicolor, intertrigo, and verruca vulgaris are widespread. Read More

    High Altitude Dermatology.
    Indian J Dermatol 2017 Jan-Feb;62(1):59-65
    Department of Dermatology, Military Hospital, Ahmedabad, Gujarat, India.
    Approximately, 140 million people worldwide live permanently at high altitudes (HAs) and approximately another 40 million people travel to HA area (HAA) every year for reasons of occupation, sports or recreation. In India, whole of Ladakh region, part of Northwest Kashmir, Northern part of Sikkim and Tenga valley of Arunachal are considered inhabited areas of HAA. The low quantity of oxygen, high exposure of ultraviolet (UV) light, very low humidity, extreme subzero temperature in winter, high wind velocity, make this region difficult for lowlanders as well as for tourists. Read More

    Pigmentation Traits, Sun Exposure, and Risk of Incident Vitiligo in Women.
    J Invest Dermatol 2017 Jun 14;137(6):1234-1239. Epub 2017 Feb 14.
    Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA; Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Electronic address:
    Vitiligo is the most common cutaneous depigmentation disorder worldwide, yet little is known about specific risk factors for disease development. Using data from the Nurses' Health Study, a prospective cohort study of 51,337 white women, we examined the associations between (i) pigmentary traits and (ii) reactions to sun exposure and risk of incident vitiligo. Nurses' Health Study participants responded to a question about clinician-diagnosed vitiligo and year of diagnosis (2001 or before, 2002-2005, 2006-2009, 2010-2011, or 2012+). Read More

    Protective Role of Mitochondrial Peroxiredoxin III against UVB-Induced Apoptosis of Epidermal Keratinocytes.
    J Invest Dermatol 2017 Jun 12;137(6):1333-1342. Epub 2017 Feb 12.
    Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea; College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea. Electronic address:
    UVB light induces generation of reactive oxygen species, ultimately leading to skin cell damage. Mitochondria are a major source of reactive oxygen species in UVB-irradiated skin cells, with increased levels of mitochondrial reactive oxygen species having been implicated in keratinocyte apoptosis. Peroxiredoxin III (PrxIII) is the most abundant and potent H2O2-removing enzyme in the mitochondria of most cell types. Read More

    Travelling abroad with cystic fibrosis: Assessment of risks and healthcare requirements.
    Respir Med 2017 Apr 24;125:92-93. Epub 2017 Jan 24.
    Adult Cystic Fibrosis Centre, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK. Electronic address:
    There is limited information on the risks and healthcare requirements of patients with cystic fibrosis (CF) undertaking travel abroad. Of 100 patients (mean age 24.7 years, mean FEV1 57. Read More

    Protective effects of Polypodium leucotomos extract against UVB-induced damage in a model of reconstructed human epidermis.
    Photodermatol Photoimmunol Photomed 2017 May 23;33(3):156-163. Epub 2017 Feb 23.
    Medical Direction Difa Cooper, Caronno Pertusella, Italy.
    Background: Polypodium leucotomos (PL) exerts potent antioxidant, photo-protective, and immune-modulatory activities. A reconstructed human epidermis (RHE) (Episkin) is a suitable model for the evaluation of acute UV-induced cell damage. No data regarding the photo-protective action of PL in this model are available. Read More

    Vitamin D status and risk for malignant cutaneous melanoma: recent advances.
    Eur J Cancer Prev 2017 Jan 25. Epub 2017 Jan 25.
    aInstitute of Food Sciences, National Research Council (CNR), Avellino bDepartment of Surgical, Microsurgical and Medical Sciences, University of Sassari cInstitute of Biomolecular Chemistry, National Research Council (CNR), Cancer Genetics Unit, Sassari dRomagna Scientific Institute for the Study and Cure of Tumors, Skin Cancer Unit, Meldola, Italy.
    Cutaneous malignant melanoma, whose incidence is increasing steadily worldwide, is the result of complex interactions between individual genetic factors and environmental risk factors. Ultraviolet radiation represents the most important environmental risk factor for the development of skin cancers, including melanoma. Sun exposure and early sunburn during childhood are the principal causes of cutaneous melanoma insurgence in adults, with double the risk relative to a nonexposed population. Read More

    Sun Protection by Beach Umbrella vs Sunscreen With a High Sun Protection Factor: A Randomized Clinical Trial.
    JAMA Dermatol 2017 Mar;153(3):304-308
    Department of Dermatology, New York University School of Medicine, New York.
    Importance: Sun-protective behavior affects skin cancer prevention. Shade works by physically shielding skin from direct harmful UV rays; however, skin may still remain exposed to reflected and indirect UV rays. There is no current standard metric to evaluate shade for its effectiveness in sun protection, and there is insufficient clinical evidence that a beach umbrella alone can provide adequate sun protection. Read More

    Tanning equipment use: 2014 Canadian Community Health Survey.
    Health Rep 2017 Jan;28(1):12-16
    Environmental Health Science and Research Bureau, Population Studies Division, Health Canada, Ottawa, Ontario.
    Background: Tanning equipment use is related to the early onset of cancer, with the risk increasing as the duration and repetition of exposure increase. In 2009, the International Agency for Research on Cancer classified tanning equipment use as carcinogenic to humans, and according to the World Health Organization, the risk of skin melanoma increases significantly when use begins before age 35.

    Data And Methods: The rapid response component of the 2014 Canadian Community Health Survey collected data on the use of tanning equipment in the previous 12 months, including reasons for use, frequency/duration of use, precautions taken, and adverse reactions or injuries. Read More

    Detailed Audiological Evaluation of a Patient with Xeroderma Pigmentosum with Neural Degeneration.
    J Am Acad Audiol 2017 Jan;28(1):80-90
    Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA.
    Background: Xeroderma pigmentosum (XP) is a rare autosomal recessive condition characterized by extreme sensitivity to ultraviolet light. Individuals with XP lack the ability to repair DNA (deoxyribonucleic acid) damage caused by ultraviolet radiation, leading to sunburn and increased susceptibility to skin cancers. Approximately 25% of patients also exhibit neural degeneration, which includes progressive mental deterioration, cortical thinning, and sensorineural hearing loss. Read More

    Ultraviolet radiation and the skin: Photobiology and sunscreen photoprotection.
    J Am Acad Dermatol 2017 Mar 27;76(3S1):S100-S109. Epub 2016 Dec 27.
    Clinical Skin Research and Development Center, Pierre Fabre Dermo-Cosmétique, Toulouse, France; Department of Dermatology, Toulouse University Hospital, Toulouse, France.
    The efficacy of sunscreens can be measured by different methods, involving in vitro, ex vivo, or in vivo techniques. There is a need for a worldwide standardization of these methods to avoid misunderstanding and confusion among sunscreen users. The clinical benefits of sunscreens have been demonstrated in randomized controlled trials that established the role of sunscreens in the prevention of actinic keratoses, squamous cell carcinomas, nevi, and melanomas. Read More

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