49,175 results match your criteria Sudden Visual Loss

Eye movements and the perceived location of phosphenes generated by intracranial primary visual cortex stimulation in the blind.

Brain Stimul 2021 May 12. Epub 2021 May 12.

Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA.

Background: Restoring sight for the blind using electrical stimulation of the visual pathways is feasible but demands an understanding of the spatial mapping of the visual world at the site of targeted stimulation, whether in the retina, thalamus, or cortex. While a visual cortex stimulator can bypass the eye and create visual percepts, there is an inherent dissociation between this stimulation and eye movements. It is unknown whether and how robustly the brain maintains the oculomotor circuitry in patients with bare- or no-light perception. Read More

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Age-related ocular conditions: Current treatments and role of cyclodextrin-based nanotherapies.

Int J Pharm 2021 May 12:120707. Epub 2021 May 12.

Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, Iceland. Electronic address:

Age-related eye disorders are chronic diseases that affect millions of people worldwide. They cause visual impairment and, in some cases, irreversible blindness. Drug targeting to the retina is still a challenge due to the difficulties with drug distribution, crossing eye barriers, and reaching intraocular tissues in an effective therapeutic concentration. Read More

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Building supply chain capacity for neglected tropical diseases: experience from the Ascend West and Central Africa programme.

Trans R Soc Trop Med Hyg 2021 May 15. Epub 2021 May 15.

Hypha Group Limited, 320 Firecrest Court Centre Park, Warrington, UK, WA1 1RG, UK.

The Ascend West and Central Africa programme, funded by the UK Foreign, Commonwealth and Development Office (FCDO) is supporting integrated preventative chemotherapy for up to five neglected tropical diseases (NTDs), including intestinal worms, lymphatic filariasis, river blindness, trachoma and schistosomiasis. The programme is implemented across 13 countries by a consortium of four leading international development partners: Sightsavers, Liverpool School of Tropical Medicine, Schistosomiasis Control Initiative Foundation and Mott Macdonald. This paper presents messages learnt from country assessments that took place prior to the global outbreak of coronavirus disease 2019 (COVID-19). Read More

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Diabetic cataract in the Nile grass rat: A longitudinal phenotypic study of pathology formation.

FASEB J 2021 Jun;35(6):e21593

Molecular Biomarkers Nano-Imaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Diabetes is a major risk factor for cataract, the leading cause of blindness worldwide. There is an unmet need for a realistic model of diabetic cataract for mechanistic and longitudinal studies, as existing models do not reflect key aspects of the complex human disease. Here, we introduce and characterize diabetic cataract in the Nile grass rat (NGR, Arvicanthis niloticus), an established model of metabolic syndrome and type 2 diabetes (T2D). Read More

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From CASS to ischemia: Almost 40 years of blindness in stable coronary artery disease.

Joseph Emmerich

J Med Vasc 2021 May 18;46(3):105-107. Epub 2021 Mar 18.

Department of vascular medicine, Paris Saint-Joseph Hospital Group, University of Paris, INSERM CRESS UMR 1153, 185 rue Raymond Losserand, 75674 Paris Cedex 14, France. Electronic address:

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The role of the inflammasomes in the pathogenesis of uveitis.

Exp Eye Res 2021 May 11:108618. Epub 2021 May 11.

Department of Immunology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong, Jiangsu, 226019, China; Basic Medical Research Center, School of Medicine, Nantong University, Nantong, 226019, China. Electronic address:

Uveitis is a diverse group of sight-threatening intraocular inflammatory diseases usually causing eye redness, pain, blurred vision, and sometimes blindness. Although the exact pathogenesis of uveitis is not yet clear, accumulating evidences have shown that an imbalanced regulation of immune responses caused by a combination of genetic and environmental factors are implicated in the pathogenesis of this disease. As critical regulators of inflammation, inflammasomes have been assumed to play a role in the pathogenesis of uveitis. Read More

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Rab34 is necessary for early stages of intracellular ciliogenesis.

Curr Biol 2021 May 7. Epub 2021 May 7.

Program in Molecular Medicine, University of Massachusetts Medical School, Biotech II, Suite 213, 373 Plantation Street, Worcester, MA 01605, USA. Electronic address:

Primary cilia are sensory organelles present on most vertebrate cells and are critical for development and health. Ciliary dysfunction is associated with a large class of human pathologies collectively known as ciliopathies. These include cystic kidneys, blindness, obesity, skeletal malformations, and other organ anomalies. Read More

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Simpson Grade I Removal of Tuberculum Sella Meningioma Through the Supraorbital Approach: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 May 14. Epub 2021 May 14.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

As described by Cushing1 in the chiasmatic syndrome, tuberculum sellae meningiomas induce progressive asymmetrical, incongruous visual loss, which would lead to blindness. The surgical removal of these lesions has been rewarding in regard to visual preservation, or recovery, and has passed the test of time. Optic canal extension, in one or both canals, is a consistent feature of these tumors, and removing the tumor from the optic canals is paramount in the treatment of these lesions. Read More

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OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring.

EMBO Rep 2021 May 13:e52173. Epub 2021 May 13.

Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA.

Lysosomal positioning and mTOR (mammalian target of rapamycin) signaling coordinate cellular responses to nutrient levels. Inadequate nutrient sensing can result in growth delays, a hallmark of Lowe syndrome. OCRL mutations cause Lowe syndrome, but the role of OCRL in nutrient sensing is unknown. Read More

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Evaluation of preoperative corneal astigmatism using swept-source optical biometry in Chinese cataract surgery candidates with high myopia: a prospective, comparative observational study.

Ann Transl Med 2021 Apr;9(8):618

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Background: High myopia and cataracts are major causes of blindness in East and Southeast Asia. Corneal astigmatism is a major contributor to uncorrected poor vision after cataract surgery in patients with high myopia. The purpose of the present study was to evaluate the demographic characteristics and distribution of preoperative corneal astigmatism in Chinese cataract surgery candidates with high myopia. Read More

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Adenosine A3 receptor activated in HO oxidative stress of primary open-angle glaucoma.

Ann Transl Med 2021 Apr;9(7):526

Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.

Background: Primary open-angle glaucoma (POAG), as one of the leading reasons for blindness, is mainly due to trabecular meshwork (TM) dysfunction. Bioinformatics analysis was used to find related genes involved in TM oxidative stress, which is a major cause of TM fibrosis.

Methods: A total of three datasets from the Gene Expression Omnibus (GEO) database were used to identify differentially expressed genes (DEGs). Read More

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Changes in Vitamin A Levels and the Effect of Early Vitamin A Supplementation on Vitamin A Levels in Infants Throughout the First 6 Months of Life: A Prospective Cohort Study in Chongqing, China.

Front Public Health 2021 27;9:650823. Epub 2021 Apr 27.

Chongqing Key Laboratory of Child Nutrition and Health, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Nutrition Research Center, National Clinical Research Center for Child Health and Disorder, Children's Hospital of Chongqing Medical University, Chongqing, China.

This study aimed to explore the changes in infant vitamin A (VA) status and the effect of early VA supplementation on VA level throughout the first 6 months of life. A prospective cohort study was conducted in Chongqing, China. A total of 1,016 healthy infants were enrolled at birth. Read More

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Comparison of Sudden Sensorineural Hearing Loss with Tinnitus and Short-Term Tinnitus.

Neural Plast 2021 20;2021:6654932. Epub 2021 Apr 20.

Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.

Objective: As one of the common symptoms of sudden sensorineural hearing loss (SSH), tinnitus seriously affects the life and work of SSH patients. The present study is aimed at exploring whether SSH can receive acoustic therapy and the factors that affect the efficacy of SSH acoustic therapy.

Methods: A total of 162 patients were outpatients and inpatients, 86 were SSH, and 76 were short-term tinnitus (STT). Read More

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The population-based prevalence of trachomatous scarring in a trachoma hyperendemic setting: results from 152 impact surveys in Amhara, Ethiopia.

BMC Ophthalmol 2021 May 13;21(1):213. Epub 2021 May 13.

The Carter Center, GA, Atlanta, USA.

Background: Trachomatous scarring (TS) results from repeated infection with the bacterium Chlamydia trachomatis. Pronounced scarring is an underlying cause of trachomatous trichiasis (TT) that can lead to blindness. Since the condition is irreversible, TS in adults has been considered a marker of past exposure to trachoma infection. Read More

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Typical Crossmodal Numerosity Perception in Preterm Newborns.

Multisens Res 2021 May 12:1-22. Epub 2021 May 12.

Department of Developmental Neuroscience, IRCCS Fondazione Stella Maris, 56128 Calambrone, Pisa, Italy.

Premature birth is associated with a high risk of damage in the parietal cortex, a key area for numerical and non-numerical magnitude perception and mathematical reasoning. Children born preterm have higher rates of learning difficulties for school mathematics. In this study, we investigated how preterm newborns (born at 28-34 weeks of gestation age) and full-term newborns respond to visual numerosity after habituation to auditory stimuli of different numerosities. Read More

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Safety in Dermatologic Procedures: Vascular Occlusion by Filling Materials.

Actas Dermosifiliogr 2021 May 10. Epub 2021 May 10.

Servicio de Radiología Intervencionista. Avda. de Córdoba s/n, 28041, Madrid, España.

Ischemic events are the most serious complications of facial antiaging treatment with dermal fillers. Ischemia can cause Nicolau syndrome, blindness, or even stroke. This article discusses how to prevent ischemic complications and what steps to take should a dermatologic emergency develop. Read More

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Updated Numbers on the State of Visual Acuity Loss and Blindness in the US.

Emily Y Chew

JAMA Ophthalmol 2021 May 13. Epub 2021 May 13.

Division of Epidemiology and Clinical Applications, National Eye Institute/National Institutes of Health, Bethesda, Maryland.

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Prevalence of Visual Acuity Loss or Blindness in the US: A Bayesian Meta-analysis.

JAMA Ophthalmol 2021 May 13. Epub 2021 May 13.

NORC at the University of Chicago, Chicago, Illinois.

Importance: Globally, more than 250 million people live with visual acuity loss or blindness, and people in the US fear losing vision more than memory, hearing, or speech. But it appears there are no recent empirical estimates of visual acuity loss or blindness for the US.

Objective: To produce estimates of visual acuity loss and blindness by age, sex, race/ethnicity, and US state. Read More

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Fundus albipunctatus photoreceptor microstructure revealed using adaptive optics scanning light ophthalmoscopy.

Am J Ophthalmol Case Rep 2021 Jun 16;22:101090. Epub 2021 Apr 16.

Icahn School of Medicine at Mount Sinai and New York Eye and Ear Infirmary of Mount Sinai, Department of Ophthalmology, New York, NY, USA.

Purpose: Fundus albipunctatus is an inherited cause of congenital stationary night blindness. The objective of this report is to describe structural changes occurring in a macular phenotype of a novel RDH5 mutation producing fundus albipunctatus using high-resolution imaging. A 62-year-old male with longstanding night blindness underwent imaging and genetic evaluation. Read More

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Identification of a Rare Exon 19 Skipping Mutation in ALMS1 Gene in Alström Syndrome Patients From Two Unrelated Saudi Families.

Front Pediatr 2021 26;9:652011. Epub 2021 Apr 26.

Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.

Alström syndrome (AS) is a very rare childhood disorder characterized by cardiomyopathy, progressive hearing loss and blindness. Inherited genetic variants of ALMS1 gene are the known molecular cause of this disease. The objective of this study was to characterize the genetic basis and understand the genotype-phenotype relationship in Saudi AS patients. Read More

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Orbital Cellulitis Secondary to Dental Abscess in Children.

Cureus 2021 Apr 9;13(4):e14392. Epub 2021 Apr 9.

Ophthalmology Clinic, Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kelantan, MYS.

Paediatric orbital cellulitis is a potential sight- and life-threatening condition. It is a serious infection in children that can result in significant complications, including blindness, cavernous sinus thrombosis, cerebral venous sinus thrombosis, meningitis, subdural empyema, and brain abscess. Of the patients with orbital cellulitis, 17% died from meningitis, and 20% of the survivors had permanent loss of vision. Read More

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Prevalence of visual impairment among older Chinese population: A systematic review and meta-analysis.

J Glob Health 2021 May 1;11:08004. Epub 2021 May 1.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Background: To evaluate the prevalence of visual impairment (VI) among elderly Chinese population.

Methods: All population-based studies on VI prevalence among elderly Chinese populations were searched and only studies with clear definitions of diagnosis were selected. Meta-analysis methods were used to estimate the pooled prevalence and its 95% confidence interval (95%CI) of moderate and severe visual impairment (MSVI) and blindness both by presenting visual acuity (PVA) and best corrected visual acuity (BCVA). Read More

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Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222).

Front Immunol 2021 26;12:653786. Epub 2021 Apr 26.

Neurosurgery Service, Complejo Hospitalario Metropolitano, CSS, Panama City, Panama.

Introduction: Although acute transverse myelitis (ATM) is a rare neurological condition (1.34-4.6 cases per million/year) COVID-19-associated ATM cases have occurred during the pandemic. Read More

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Anterior Segment Findings in Ocular Myocysticercosis in Children: Is it non- specific?

Nepal J Ophthalmol 2021 Jan;13(25):141-145

Nirwana Netralaya, Athkhambhwa, Sasaram- 821115, Bihar, India.

Ocular cysticercosis is a preventable cause of blindness. Medical therapy has been recommended for the retro-orbital and extraocular muscle form. Surgical management is largely done in cases with conjunctival or lid affliction. Read More

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January 2021

Glaucoma in Developing Countries.

Nepal J Ophthalmol 2021 Jan;13(25):112-121

Head, Department of Glaucoma and Research, Tilganga Institute of Ophthalmology, Kathmandu, Nepal.

Glaucoma is a leading cause of blindness worldwide. The diagnosis and management of glaucoma is especially difficult in the developing countries. Lack of cost effective screening strategies, low income, low rates of literacy and inadequate infrastructures and human resources for eye care services are the obstacles for delivering glaucoma service. Read More

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January 2021

Profile of Secondary Glaucoma in a Tertiary Eye Hospital of Eastern Nepal.

Nepal J Ophthalmol 2021 Jan;13(25):98-103

Gandaki Medical College Teaching Hospital and Research Centre, Pokhara, Nepal.

Background: To determine the clinical profile and causes of various types of secondary glaucoma.

Materials And Methods: This was a hospital-based cross-sectional study conducted in a tertiary eye hospital of eastern Nepal from 1st June to 30th November, 2017. Patients who met the criteria for secondary glaucoma underwent detailed ophthalmic examination. Read More

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January 2021

Firework-related Ocular Injuries During Festival Season: A Hospitalbased Study in a Tertiary Eye Care Center of Nepal.

Nepal J Ophthalmol 2021 Jan;13(25):31-39

Sagarmatha Chaudhary Eye Hospital, Lahan, Siraha, Nepal.

Introduction: Firework-related ocular injuries are an important cause of preventable ocular injuries and are common during the festival season. Despite the strict legislation in Nepal, the use of a firework is still commonly used during Tihar and Chaath festivals.

Objective: To evaluate demographic distribution, mode, causative firework, type of fireworks-related ocular injuries, and visual outcome at a tertiary eye hospital in Eastern Nepal. Read More

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January 2021

Comparative Study on Knowledge and Awareness of Common Ocular Diseases Among Rural and Urban Community in Siraha District of Nepal: The Lahan Study.

Nepal J Ophthalmol 2021 Jan;13(25):13-21

Consultant Ophthalmologist, Sagarmatha Choudhary Eye Hospital, Lahan, Nepal.

Introduction: Awareness and knowledge about the common ocular conditions can help people to seek early eye care services. The understanding and acceptance of the importance of routine eye examinations can help in timely detection and treatment of the eye diseases and thus help to reduce the burden of avoidable ocular blindness from the general population.

Objective: This study aims to assess and analyze the information related to knowledge and awareness of common ocular diseases and eye health among the rural and urban communities of the Siraha district, Nepal. Read More

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January 2021

Prevalence and Causes of Visual Impairment and Blindness in Three Ecological Regions of Nepal.

Nepal J Ophthalmol 2021 Jan;13(25):4-12

Tilganga Institute of Ophthalmology, Kathmandu, Nepal.

Introduction: Visual impairment and blindness are significant public health issues worldwide. The objective of this study was to estimate the prevalence and causes of moderate to severe visual impairment (MSVI) and blindness in people aged 15 years and above across three ecological regions of Nepal.

Materials And Methods: A comparative cross-sectional study was conducted in one district in each of the three ecological regions of Nepal. Read More

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January 2021

Development and validation of a new clinical decision support tool to optimize screening for retinopathy of prematurity.

Br J Ophthalmol 2021 May 12. Epub 2021 May 12.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background/aims: Prematurely born infants undergo costly, stressful eye examinations to uncover the small fraction with retinopathy of prematurity (ROP) that needs treatment to prevent blindness. The aim was to develop a prediction tool (DIGIROP-Screen) with 100% sensitivity and high specificity to safely reduce screening of those infants not needing treatment. DIGIROP-Screen was compared with four other ROP models based on longitudinal weights. Read More

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