Acta Biomater 2022 May 10. Epub 2022 May 10.
Aier Eye Institute, Changsha, Hunan Province, China; Aier School of Ophthalmology, Central South University, Changsha, Hunan, China; Key Laboratory for Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou, China. Electronic address:
Corneal nerve wounding often causes abnormalities in the cornea and even blindness in severe cases. In this study, we construct a dorsal root ganglion-corneal stromal cell (DRG-CSC, DS) co-culture 3D model to explore the mechanism of corneal nerve regeneration. Firstly, this model consists of DRG collagen grafts sandwiched by orthogonally stacked and orderly arranged CSC-laden plastic compressed collagen. Read More