938 results match your criteria Sudden Unexpected Death in Epilepsy


The effect of generalized seizure activity on ischemia-induced cardiac arrhythmias and myocardial injury with histopathological evaluation in anesthetized rats

Turk J Med Sci 2018 Dec 12;48(6):1293-1301. Epub 2018 Dec 12.

Department of Physiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey

Background/aim: Epileptic seizure leads to sudden unexpected death in epilepsy (SUDEP) among affected patients. The causes of SUDEP are still unclear. The aim of this study was to research the effect of epilepsy on myocardial injury and arrhythmias during experimentally induced acute myocardial ischemia. Read More

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http://dx.doi.org/10.3906/sag-1807-99DOI Listing
December 2018

[Sudden death in epilepsy].

Rev Med Chil 2018 Aug;146(8):902-908

Liga Chilena contra la Epilepsia, Clínica Dávila, Clínica Universidad de los Andes, Santiago, Chile.

The risk of sudden unexpected death in patients with epilepsy (SUDEP), is 20 to 25 times greater than in the general population. This increased risk is seen specially in refractory epilepsy, with an incidence of 9:1,000 patients-years. Risk factors have been established based on retrospective studies, finding that the frequency of seizures, specially generalized tonic clonic seizures, is the most important one. Read More

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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.4067/s0034-98872018000800902DOI Listing
August 2018
1 Read

What information about sudden unexpected death in epilepsy (SUDEP) is available on YouTube?

Epilepsy Behav 2018 Dec 6. Epub 2018 Dec 6.

Charleston Area Medical Center, Charleston, WV, USA; West Virginia University/Charleston Division, Charleston, WV, USA.

Objective: We sought to assess and analyze the information available about sudden unexpected death in epilepsy (SUDEP) and the general perception of this condition by the public on YouTube.

Methods: We evaluated all consecutive videos containing references to 'sudden unexpected death in epilepsy' and 'SUDEP' on YouTube. Data were extracted after applying the inclusion and exclusion criteria. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.10.017DOI Listing
December 2018

A systematic review of sudden unexpected death in epilepsy (SUDEP) in childhood.

Epilepsy Behav 2018 Dec 3;90:99-106. Epub 2018 Dec 3.

Population, Policy and Practice Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

Background: Sudden Unexpected Death in Epilepsy (SUDEP) is a significant cause of death in childhood epilepsy, and causes considerable concern to patients and their families. Despite this, the condition remains poorly understood. This systematic review investigates the risk factors, pathophysiology, and circumstances associated with childhood SUDEP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183082
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http://dx.doi.org/10.1016/j.yebeh.2018.11.006DOI Listing
December 2018
15 Reads

Altered A-Type Potassium Channel Function in the Nucleus Tractus Solitarius in Acquired Temporal Lobe Epilepsy.

J Neurophysiol 2018 Dec 5. Epub 2018 Dec 5.

Neuroscience, University of Kentucky College of Medicine, United States.

Sudden unexpected death in epilepsy (SUDEP) is among the leading causes of death in people with epilepsy. Individuals with temporal lobe epilepsy (TLE) have a high risk for SUDEP because the seizures are often medically intractable. Neurons in the nucleus tractus solitarius (NTS) have been implicated in mouse models of SUDEP and play a critical role in modulating cardiorespiratory and autonomic output. Read More

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http://dx.doi.org/10.1152/jn.00556.2018DOI Listing
December 2018
2 Reads

Autonomic aspects of sudden unexpected death in epilepsy (SUDEP).

Clin Auton Res 2018 Nov 19. Epub 2018 Nov 19.

Department of Neurology, Jefferson Comprehensive Epilepsy Center, Sidney Kimmel Medical College at Thomas Jefferson University, 901 Walnut Street, Suite 400, Philadelphia, PA, 19107, USA.

Sudden unexpected death in epilepsy (SUDEP) is a major cause of epilepsy-related mortality. SUDEP is highly linked to seizures, with most deaths occurring after convulsive seizures in sleep. In most cases of SUDEP, convulsive seizures appear to directly trigger catastrophic cardiorespiratory dysfunction leading to death. Read More

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http://link.springer.com/10.1007/s10286-018-0576-1
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http://dx.doi.org/10.1007/s10286-018-0576-1DOI Listing
November 2018
6 Reads

Sudden unexpected death in epilepsy: Risk factors, biomarkers, and prevention.

Acta Neurol Scand 2018 Nov 15. Epub 2018 Nov 15.

Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio.

Sudden unexpected death in epilepsy (SUDEP) is one of the most important direct epilepsy-related causes of death, with an incidence in adults of 1.2 per 1000 person-years. Generalized tonic-clonic seizures have consistently emerged as the leading risk factor for SUDEP, particularly when such seizures are uncontrolled. Read More

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http://doi.wiley.com/10.1111/ane.13049
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http://dx.doi.org/10.1111/ane.13049DOI Listing
November 2018
7 Reads

Neuro-Glial Network Model Of Postictal Generalized EEG Suppression (PGES).

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:2044-2047

Over the past couple of decades, glial cells have been highlighted as active agents in hyperexcitability of neuronal networks, specifically playing key roles in seizure onset and termination. In particular, microglia have been suggested to have both neuroprotective and neurotoxic effects on the brain. Investigation into seizure termination is of particular interest, as it is sometimes followed by a postictal generalized EEG suppression (PGES) - a low activity state that is potentially associated with sudden unexpected death in epilepsy. Read More

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http://dx.doi.org/10.1109/EMBC.2018.8512661DOI Listing

Ictal hypoxemia: A systematic review and meta-analysis.

Seizure 2018 Dec 21;63:7-13. Epub 2018 Oct 21.

Institute of Psychiatry, Psychology & Neuroscience, Division of Neuroscience, King's College London, UK. Electronic address:

Purpose: To estimate the incidence of ictal hypoxemia (IH) and to identify clinical and study-related factors modulating the estimate.

Methods: We searched articles recording concurrent peri-ictal and ictal EEG and Sp02 in adults and children with epilepsy. Studies reporting the total number of seizures recorded and the number of seizures with IH were included in a random-effects meta-analysis. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.10.011DOI Listing
December 2018
1 Read

Ictal Asystole in Temporal Lobe Epilepsy: A Possible Cause of Sudden Unexplained Death - A Case Report.

Neurodiagn J 2018 Nov 2:1-5. Epub 2018 Nov 2.

a Department of Neurology University of Oklahoma Health Sciences Center , Oklahoma City , Oklahoma.

We report a case of a 47-year-old woman who presented with a 3-year history of paroxysmal events after suffering traumatic brain injury in a motor vehicle accident. She had not previously been diagnosed with epilepsy. On video-EEG monitoring, she was found to have a right temporal seizure associated with ictal asystole lasting for 18 seconds. Read More

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https://www.tandfonline.com/doi/full/10.1080/21646821.2018.1
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http://dx.doi.org/10.1080/21646821.2018.1531671DOI Listing
November 2018
4 Reads

Heart rate variability measurement in epilepsy: How can we move from research to clinical practice?

Epilepsia 2018 Dec 21;59(12):2169-2178. Epub 2018 Oct 21.

Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.

Our objective was to critically evaluate the literature surrounding heart rate variability (HRV) in people with epilepsy and to make recommendations as to how future research could be directed to facilitate and accelerate integration into clinical practice. We reviewed relevant HRV publications including those involving human subjects with seizures. HRV has been studied in patients with epilepsy for more than 30 years and, overall, patients with epilepsy display altered interictal HRV, suggesting a shift in autonomic balance toward sympathetic dominance. Read More

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http://dx.doi.org/10.1111/epi.14587DOI Listing
December 2018

Acid reflux induced laryngospasm as a potential mechanism of sudden death in epilepsy.

Epilepsy Res 2018 Dec 9;148:23-31. Epub 2018 Oct 9.

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, US; Department of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, US. Electronic address:

Objective: Recent research suggests that obstructive laryngospasm and consequent respiratory arrest may be a mechanism in sudden unexpected death in epilepsy. We sought to test a new hypothesis that this laryngospasm is caused by seizures driving reflux of stomach acid into the larynx, rather than spontaneous pathological activity in the recurrent laryngeal nerve.

Approach: We used an acute kainic acid model under urethane anesthesia to observe seizure activity in Long-Evans rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183032
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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276113PMC
December 2018
6 Reads

Deceleration and acceleration capacities of heart rate in patients with drug-resistant epilepsy.

Clin Auton Res 2018 Oct 16. Epub 2018 Oct 16.

National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, 100084, China.

Objective: Epilepsy and seizures can have dramatic effects on cardiac function. The aim of the present study was to investigate deceleration capacity, acceleration capacity and their 24-h fluctuations of heart rate variability in patients with drug-resistant epilepsy.

Methods: Deceleration capacity, acceleration capacity of heart rate and their 24-h dynamics derived from the phase rectified signal averaging method as well as traditional measures were analyzed in 39 patients with drug-resistant epilepsy and 33 healthy control subjects using 24-h electrocardiogram recordings. Read More

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http://link.springer.com/10.1007/s10286-018-0569-0
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http://dx.doi.org/10.1007/s10286-018-0569-0DOI Listing
October 2018
6 Reads
1.864 Impact Factor

Post-ictal Modulation of Baroreflex Sensitivity in Patients With Intractable Epilepsy.

Front Neurol 2018 26;9:793. Epub 2018 Sep 26.

Department of Electrical Engineering and Computer Science, Case School of Engineering, Case Western Reserve University, Cleveland, OH, United States.

Seizure-related autonomic dysregulation occurs in epilepsy patients and may contribute to Sudden Unexpected Death in Epilepsy (SUDEP). We tested how different types of seizures affect baroreflex sensitivity (BRS) and heart rate variability (HRV). We hypothesized that BRS and HRV would be reduced after bilateral convulsive seizures (BCS). Read More

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http://dx.doi.org/10.3389/fneur.2018.00793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168624PMC
September 2018
1 Read

Obstructive sleep apnea in refractory epilepsy: A pilot study investigating frequency, clinical features, and association with risk of sudden unexpected death in epilepsy.

Epilepsia 2018 10 24;59(10):1973-1981. Epub 2018 Sep 24.

Mayo Center for Sleep Medicine, Mayo Clinic and Foundation, Rochester, Minnesota.

Objective: We aimed to determine the frequency of probable obstructive sleep apnea (pOSA) in refractory epilepsy monitoring unit inpatients and clinical features associated with pOSA, including risk for sudden unexpected death in epilepsy (SUDEP).

Methods: We prospectively recruited 49 consecutive adult patients admitted to the Mayo Clinic Epilepsy Monitoring Unit with focal, generalized, or unclassified epilepsy syndromes. pOSA was identified using oximetric oxyhemoglobin desaturation index (ODI) and the Sleep Apnea-Sleep Disorders Questionnaire (SA-SDQ) and STOP-BAG screening tools. Read More

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http://dx.doi.org/10.1111/epi.14548DOI Listing
October 2018
1 Read

Nocturnal supervision and SUDEP risk at different epilepsy care settings.

Neurology 2018 Oct 21;91(16):e1508-e1518. Epub 2018 Sep 21.

From the Stichting Epilepsie Instellingen Nederland (SEIN) (M.v.d.L., J.W.S., R.D.T.), Heemstede; Leiden University Medical Center (LUMC) (M.v.d.L., R.D.T.), Netherlands; GH Sergievsky Center and Department of Epidemiology (D.C.H.), Columbia University, New York, NY; NIHR University College London Hospitals Biomedical Research Centre (J.W.S., R.D.T.), UCL Institute of Neurology, Queen Square, London, and Chalfont Centre for Epilepsy, Chalfont St Peter, UK.

Objective: To estimate the incidence of sudden unexpected death in epilepsy (SUDEP) in people with intellectual disabilities in residential care settings and to ascertain the effects of nocturnal seizures and nocturnal supervision on SUDEP risk.

Methods: We conducted a nested case-control study reviewing records of all people who died at 2 residential care settings over 25 years. Four controls per case were selected from the same population, matched on age (±5 years) and residential unit. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006356DOI Listing
October 2018
1 Read
8.290 Impact Factor

Sleep-disordered breathing, neuroendocrine function, and clinical SUDEP risk in patients with epilepsy.

Epilepsy Behav 2018 Aug 31;87:78-82. Epub 2018 Aug 31.

Comprehensive Epilepsy and Sleep Center, Department of Neurology, Columbia University Medical Center New York, NY, United States.

Introduction: Sudden unexpected death in epilepsy (SUDEP) is a major contributor to epilepsy-related mortality. It is associated with nocturnal seizures and centrally mediated postictal cardiorespiratory dysfunction (CRD), but mechanisms and contributors remain poorly understood.

Methods: We performed a prospective, cross-sectional, observational pilot study in the Columbia University Medical Center (CUMC) adult epilepsy monitoring unit (EMU) to explore relationships between periictal CRD, sleep-disordered breathing (SDB), neuroendocrine function, and clinical SUDEP risk. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.07.011DOI Listing
August 2018
1 Read

Ictal Mammalian Dive Response: A Likely Cause of Sudden Unexpected Death in Epilepsy.

Authors:
Jose L Vega

Front Neurol 2018 17;9:677. Epub 2018 Aug 17.

Department of Neurosciences and Stroke, Novant Health, Forsyth Medical Center, Winston-Salem, NC, United States.

Even though sudden unexpected death in epilepsy (SUDEP) takes the lives of thousands of otherwise healthy epilepsy patients every year, the physiopathology associated with this condition remains unexplained. This article explores important parallels, which exist between the clinical observations and pathological responses associated with SUDEP, and the pathological responses that can develop when a set of autonomic reflexes known as the mammalian dive response (MDR) is deployed. Mostly unknown to physicians, this evolutionarily conserved physiological response to prolonged apnea economizes oxygen for preferential use by the brain. Read More

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http://dx.doi.org/10.3389/fneur.2018.00677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108060PMC

From fix to fit into the autoptic human brains.

Eur J Histochem 2018 Aug 27;62(3). Epub 2018 Aug 27.

University of Milan, "Lino Rossi" Research Center for the study and prevention of unexpected perinatal death and SIDS Department of Biomedical, Surgical and Dental Sciences; Cardiovascular Pathology Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua Medical School, Padua; Department of Medical Sciences, Section of Pharmacology and National Institute of Neuroscience, University of Ferrara.

Formalin-fixed, paraffinembedded (FFPE) human brain tissues are very often stored in formalin for long time. Formalin fixation reduces immunostaining, and the DNA/RNA extraction from FFPE brain tissue becomes suboptimal. At present, there are different protocols of fixation and several procedures and kits to extract DNA/RNA from paraffin embedding tissue, but a gold standard protocol remains distant. Read More

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https://www.ejh.it/index.php/ejh/article/view/2944
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http://dx.doi.org/10.4081/ejh.2018.2944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151333PMC
August 2018
7 Reads

Autopsy findings of SUDEP in adolescence.

Authors:
D Afandi I Romus

Malays J Pathol 2018 Aug;40(2):185-189

Universitas Riau, Faculty of Medicine, Forensic Medicine and Medicolegal Studies Department, Jl. Diponegoro 1, Pekanbaru, Riau, Indonesia.

Sudden unexpected death in epilepsy (SUDEP) is a rare in children; the risk of SUDEP in children is up to 10-fold less than adults. Herein, we report a case of SUDEP in a 14-year-old boy. The post-mortem findings in neuropathological examination in SUDEP are not pathognomonic. Read More

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August 2018
9 Reads

Deficient post-ictal cardiorespiratory compensatory mechanisms mediated by the periaqueductal gray may lead to death in a mouse model of SUDEP.

Epilepsy Res 2018 Nov 19;147:1-8. Epub 2018 Aug 19.

Departments of Pharmacology and Neurology, Southern Illinois University School of Medicine, PO BOX 19629, Springfield, IL, 62794-9629, United States. Electronic address:

Post-ictal cardiorespiratory failure is implicated as a major cause of sudden unexpected death in epilepsy (SUDEP) in patients. The DBA/1 mouse model of SUDEP is abnormally susceptible to fatal seizure-induced cardiorespiratory failure (S-CRF) induced by convulsant drug, hyperthermia, electroshock, and acoustic stimulation. Clinical and pre-clinical studies have implicated periaqueductal gray (PAG) abnormalities in SUDEP. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.08.005DOI Listing
November 2018
12 Reads

The analysis of circadian rhythm of heart rate variability in patients with drug-resistant epilepsy.

Epilepsy Res 2018 Oct 6;146:151-159. Epub 2018 Aug 6.

National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, 100084, Beijing, China; Man-Machine-Environment Engineering Institute, School of Aerospace Engineering, Tsinghua University, 100084, Beijing, China; Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, 518055, Shenzhen, China; Center of Epilepsy, Beijing Institute for Brain Disorders, 100069, Beijing, China. Electronic address:

Objective: The aim of this study was to investigate the variations and the circadian rhythm of multi-domain parameters of heart rate variability (HRV) in patients with drug-resistant epilepsy.

Methods: Time domain HRV parameters of 24-hour data, frequency and non-linear domain HRV parameters were calculated using a 24-hour ambulatory electrocardiogram (ECG) from subjects in a resting and awake state (5-min data from 9:00-10:00 a.m. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.08.002DOI Listing
October 2018
21 Reads
2.020 Impact Factor

Sudden unexpected death in epilepsy, periictal physiology, and the SUDEP-7 Inventory.

Epilepsia 2018 Oct 29;59(10):e157-e160. Epub 2018 Aug 29.

New York Presbyterian Hospital and Columbia University Medical Center, New York, New York.

Sudden unexpected death in epilepsy (SUDEP) is a significant public health burden. Epidemiological studies have identified clinical SUDEP risk factors across large populations, but the means to apply this information to individual patients are lacking. The SUDEP-7 Inventory was developed as a marker of clinical SUDEP risk and has been used in studies of potential SUDEP biomarkers. Read More

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http://dx.doi.org/10.1111/epi.14552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204287PMC
October 2018

Cortical thinning in epilepsy patients with postictal generalized electroencephalography suppression.

Eur J Neurol 2019 Jan 27;26(1):191-197. Epub 2018 Sep 27.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background And Purpose: The aim was to investigate the brain microstructural abnormalities in epilepsy patients with postictal generalized electroencephalographic suppression (PGES) using a cortical surface-based analysis.

Methods: According to the video-electroencephalography records of epilepsy patients with generalized convulsive seizures, 30 patients with PGES (PGES+) and 21 patients without PGES (PGES-) were recruited. High-resolution T1-weighted images were acquired from each patient and 30 matched healthy control subjects. Read More

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http://dx.doi.org/10.1111/ene.13794DOI Listing
January 2019

Dead in the water: Epilepsy-related drowning or sudden unexpected death in epilepsy?

Epilepsia 2018 Oct 26;59(10):1966-1972. Epub 2018 Aug 26.

Department of Neurology, New York University, School of Medicine, Epilepsy Center, New York, New York.

Objective: Both drowning and sudden unexpected death in epilepsy (SUDEP) are diagnoses of exclusion with predominantly nonspecific autopsy findings. We hypothesized that people with epilepsy found dead in water with no clear sign of submersion could be misdiagnosed as SUDEP.

Methods: All reported seizure-related deaths undergoing medicolegal investigation in three medical examiner's offices (New York City, Maryland, San Diego County) over different time periods were reviewed to identify epilepsy-related drownings and SUDEPs. Read More

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http://dx.doi.org/10.1111/epi.14546DOI Listing
October 2018
9 Reads

Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes.

Stem Cell Reports 2018 Sep 23;11(3):626-634. Epub 2018 Aug 23.

Department of Pharmacology, University of Michigan Medical School, 2301E MSRB III, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan Medical School, 5021 BSRB, Ann Arbor, MI 48109, USA. Electronic address:

Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy with a high incidence of sudden unexpected death in epilepsy (SUDEP). Most DS patients carry de novo variants in SCN1A, resulting in Na1.1 haploinsufficiency. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22136711183031
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http://dx.doi.org/10.1016/j.stemcr.2018.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135724PMC
September 2018
14 Reads

Two predictors of postictal generalized EEG suppression: Tonic phase duration and postictal immobility period.

Seizure 2018 Oct 16;61:135-138. Epub 2018 Aug 16.

Epilepsy Department, Loghman-Hakim Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To determine the effect of different seizure characteristics on the occurrence of postictal generalized EEG suppression (PGES). PGES is considered as a potential risk factor of sudden unexpected death in epilepsy (SUDEP) by several studies.

Methods: In this retrospective cross-sectional study, episodes of generalized convulsive seizures (GCS) were reviewed in regard to state at seizure-onset, the seizure and tonic phase durations, postictal immobility (PI) duration and whether the patient received oxygen (O2) mask during the post-ictal phase. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183037
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http://dx.doi.org/10.1016/j.seizure.2018.08.009DOI Listing
October 2018
3 Reads

Ictal cardiorespiratory depression: a real risk for sudden unexpected death in epilepsy (SUDEP)?

BMJ Case Rep 2018 Aug 23;2018. Epub 2018 Aug 23.

IRCCS Instituto delle Scienze Neurologiche di Bologna, UOC Neurologia Ospedale Bellaria, Bologna, Italia.

A 61-year-old woman affected by nocturnal hypermotor seizures since the age of 2 years complained of epigastric discomfort and chocking sensation before seizure onset for the last 25 years. Telemetry unit monitoring revealed several focal seizures with left frontotemporal onset complicated with ictal asystole and apnoea. After pacemaker (PM) implantation, video-EEG monitoring coupled with extensive respiratory montage confirmed the presence of ictal central apnoea. Read More

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http://dx.doi.org/10.1136/bcr-2018-225238DOI Listing
August 2018
3 Reads

Reducing the Risk of Sudden Unexpected Death in Epilepsy (SUDEP).

Curr Treat Options Neurol 2018 Aug 22;20(10):40. Epub 2018 Aug 22.

Cornwall Partnership NHS Foundation Trust, Threemilestone Industrial Estate, Truro, TR4 9LD, UK.

Purpose Of Review: Recent reports have highlighted an increase in the number of epilepsy-related deaths. Sudden unexpected death in epilepsy (SUDEP) is thought to be the number one cause of death in chronic epilepsy. This review provides a summary of the current evidence of how to communicate, stratify, and mitigate known risk factors for SUDEP. Read More

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http://dx.doi.org/10.1007/s11940-018-0527-0DOI Listing
August 2018
2 Reads
2.170 Impact Factor

Dietary Measures to Prevent Sudden Unexpected Death in Epilepsy.

JAMA Neurol 2018 Sep;75(9):1155-1156

Krankenanstalt Rudolfstiftung, Vienna, Austria.

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http://dx.doi.org/10.1001/jamaneurol.2018.2245DOI Listing
September 2018
1 Read

Dietary Measures to Prevent Sudden Unexpected Death in Epilepsy-Reply.

JAMA Neurol 2018 Sep;75(9):1156

Department of Neurology, New York University School of Medicine, New York.

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http://dx.doi.org/10.1001/jamaneurol.2018.2254DOI Listing
September 2018
1 Read

Brainstem network disruption: A pathway to sudden unexplained death in epilepsy?

Hum Brain Mapp 2018 Dec 10;39(12):4820-4830. Epub 2018 Aug 10.

Baylor Medical College, Houston, Texas.

Observations in witnessed Sudden Unexpected Death in Epilepsy (SUDEP) suggest that a fatal breakdown of the central autonomic control could play a major role in SUDEP. A previous MR study found volume losses in the mesencephalon in focal epilepsy that were more severe and extended into the lower brainstem in two patients who later died of SUDEP. The aims of this study were to demonstrate an association (1) between brainstem volume loss and impaired autonomic control (reduced heart rate variability [HRV]); (2) between brainstem damage and time to SUDEP in patients who later died of SUDEP. Read More

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http://dx.doi.org/10.1002/hbm.24325DOI Listing
December 2018
1 Read

Sign and magnitude scaling properties of heart rate fluctuations following vagus nerve stimulation in a patient with drug-resistant epilepsy.

Epilepsy Behav Case Rep 2018 19;10:78-81. Epub 2018 Jun 19.

Autonomous University of the State of Mexico (UAEMex), Faculty of Medicine, Toluca 50180, Mexico.

Vagus nerve stimulation (VNS) therapy has been recently incorporated in Latin America as a treatment for drug-resistant epilepsy. In particular, it is known that linear analysis and fractal parameters of heart rate variability (HRV) are able to indirectly measure cardiac autonomic activity. This case report presents a 17-year-old female with drug-resistant epilepsy implanted with a VNS device. Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072651PMC
June 2018
1 Read

Regional cortical thickness changes accompanying generalized tonic-clonic seizures.

Neuroimage Clin 2018 18;20:205-215. Epub 2018 Jul 18.

Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA, USA; Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA. Electronic address:

Objective: Generalized tonic-clonic seizures are accompanied by cardiovascular and respiratory sequelae that threaten survival. The frequency of these seizures is a major risk factor for sudden unexpected death in epilepsy (SUDEP), a leading cause of untimely death in epilepsy. The circumstances accompanying such fatal events suggest a cardiovascular or respiratory failure induced by unknown neural processes rather than an inherent cardiac or lung deficiency. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183022
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http://dx.doi.org/10.1016/j.nicl.2018.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073085PMC
July 2018
9 Reads

The landscape of epilepsy-related GATOR1 variants.

Genet Med 2018 Aug 10. Epub 2018 Aug 10.

Sorbonne Université, UPMC Univ Paris 06, UMR S 1127, F-75013, Paris, France.

Purpose: To define the phenotypic and mutational spectrum of epilepsies related to DEPDC5, NPRL2 and NPRL3 genes encoding the GATOR1 complex, a negative regulator of the mTORC1 pathway METHODS: We analyzed clinical and genetic data of 73 novel probands (familial and sporadic) with epilepsy-related variants in GATOR1-encoding genes and proposed new guidelines for clinical interpretation of GATOR1 variants.

Results: The GATOR1 seizure phenotype consisted mostly in focal seizures (e.g. Read More

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http://www.nature.com/articles/s41436-018-0060-2
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http://dx.doi.org/10.1038/s41436-018-0060-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292495PMC
August 2018
11 Reads

Predictors of Seizure-Related Injuries in an Epilepsy Cohort from North India.

J Epilepsy Res 2018 Jun 30;8(1):27-32. Epub 2018 Jun 30.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Background And Purpose: To identify predictors of seizure-related injury (SRI) and death in people with epilepsy (PWE) in a North Indian cohort.

Methods: This ambispective cohort study included PWE registered in an epilepsy clinic in Delhi between May 2010 and December 2011. Five hundred twenty-six patients were enrolled and followed for 25 months. Read More

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http://dx.doi.org/10.14581/jer.18005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066697PMC

Under-reporting of sudden unexpected death in epilepsy.

Epileptic Disord 2018 Aug;20(4):270-278

Division of Cardiology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

The identification and characterization of sudden unexpected deaths in epilepsy (SUDEP) may be improved, helping to optimize prevention and intervention. We set out to assess the frequency and demographic and clinical characteristics of SUDEP cases in a sudden death cohort. All out-of-hospital deaths were investigated from March 1, 2013 to February 28, 2015 in Wake County, NC, attended by the Emergency Medical Services. Read More

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http://dx.doi.org/10.1684/epd.2018.0979DOI Listing
August 2018
1 Read

Sudden unexpected death in epilepsy in a patient with a cardiac pacemaker.

Seizure 2018 10 17;61:38-40. Epub 2018 Jul 17.

Department of Neurology, Brigham and Women's Hospital, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2018.07.012DOI Listing
October 2018
5 Reads

Effects of Chronic Carbamazepine Treatment on the ECG in Patients with Focal Seizures.

Clin Drug Investig 2018 Sep;38(9):845-851

Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands.

Background And Objectives: Several mechanisms have been proposed for the sudden unexpected death in epilepsy patients, such as cardiac arrhythmias, a decrease in heart rate variability and the use of anti-epileptic drugs (AEDs). Although carbamazepine is commonly used as an AED, the exact working mechanism of this drug as well as its effect on the heart are not completely understood. The aim of this study was to determine whether chronic carbamazepine therapy in patients with focal seizures and impaired awareness has an effect on the electrocardiogram (ECG). Read More

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http://dx.doi.org/10.1007/s40261-018-0677-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153966PMC
September 2018
1 Read

Ictal asystole: a case presentation.

BMC Neurol 2018 Jul 21;18(1):100. Epub 2018 Jul 21.

Neurology Department, Faculty of Medicine, Kasr Alainy Hospital, Cairo University, Cairo, Egypt.

Background: Epileptic seizures can lead to cardiac arrhythmias. The arrhythmias may be in the form of tachycardia, bradycardia or asystole. Ictal bradycardia and asystole can lead to sudden unexpected death. Read More

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http://dx.doi.org/10.1186/s12883-018-1105-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054725PMC
July 2018
11 Reads
2.040 Impact Factor

Cannabis for pediatric epilepsy: protocol for a living systematic review.

Syst Rev 2018 Jul 18;7(1):95. Epub 2018 Jul 18.

School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Ottawa, K1G 5Z3, Canada.

Background: Pediatric epilepsy, including treatment-resistant forms, has a major effect on the quality of life, morbidity, and mortality of affected children. Interest has been growing in the use of medical cannabis as a treatment for pediatric epilepsy, yet there has been no comprehensive review of the benefits and harms of cannabis use in this population. In this systematic review, we will search for, synthesize, and assess the published and gray literature in order to provide usable and relevant information to parents, clinicians, and policy makers. Read More

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http://dx.doi.org/10.1186/s13643-018-0761-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052624PMC
July 2018
15 Reads

Vagus nerve stimulation (VNS) therapy update.

Epilepsy Behav 2018 Nov 13;88S:2-10. Epub 2018 Jul 13.

Department of Clinical Neurosciences, Lausanne University Hospital, Lausanne, Switzerland.

Epilepsy affects millions of people worldwide. Approximately one-third have pharmacoresistant epilepsy, and of these, the majority are not candidates for epilepsy surgery. Vagus nerve stimulation (VNS) therapy has been an option to treat pharmacoresistant seizures for 30 years. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.06.032DOI Listing
November 2018
1 Read

Incidence rate of sudden death in epilepsy: A systematic review and meta-analysis.

Epilepsy Behav 2018 Sep 13;86:193-199. Epub 2018 Jul 13.

Centre of Epidemiology and Biostatistics, Oslo University Hospital, Oslo, Norway; Centre of Clinical Heart Research, Oslo University Hospital, Oslo, Norway.

Objective: The aim of the study was to summarize the pooled incidence rate of sudden unexpected death in epilepsy (SUDEP) in patients. Meta-regression analysis was applied to identify factors influencing the incidence rate.

Design: The study was a systematic review and critical appraisal with a meta-analysis of cohort studies, both prospective and retrospective. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.06.037DOI Listing
September 2018

Altered circadian rhythms and oscillation of clock genes and sirtuin 1 in a model of sudden unexpected death in epilepsy.

Epilepsia 2018 Aug 15;59(8):1527-1539. Epub 2018 Jul 15.

Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Objectives: Circadian rhythms are affected in many neurological disorders. Although sleep disturbances are known in epilepsy, data on circadian rhythm disturbances in epilepsy are sparse. Here, we examined diurnal and circadian rest-activity and sleep-wake patterns in Kcna1-null mice, which exhibit spontaneous recurrent seizures and are a model of sudden unexpected death in epilepsy. Read More

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http://dx.doi.org/10.1111/epi.14513DOI Listing
August 2018
5 Reads

SUDEP and seizure safety communication: Assessing if people hear and act.

Epilepsy Behav 2018 Sep 13;86:200-203. Epub 2018 Jul 13.

NIHR University College London Hospitals Biomedical Research Centre, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK; Chalfont Centre for Epilepsy, Chalfont St Peter, Buckinghamshire SL9 0RJ, UK; Stichting Epilepsie Instellingen Nederland (SEIN), Achterweg 5, 2103 SW Heemstede, the Netherlands.

Background: Sudden unexpected death in epilepsy (SUDEP) is a leading cause of death among people with chronic epilepsy. People with intellectual disability (ID) are overrepresented in this population. The SUDEP and Seizure Safety Checklist ("Checklist") is a tool to discuss risk factors influencing seizures and the risk of SUDEP. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.06.040DOI Listing
September 2018
14 Reads
2.260 Impact Factor

To reveal or conceal? Adult patient perspectives on SUDEP disclosure.

Epilepsy Behav 2018 Sep 9;86:79-84. Epub 2018 Jul 9.

The Ohio State University Department of Neurology, 395 W 12th St, 7th floor, Columbus, OH 43201, United States of America. Electronic address:

Objective: The study aimed to evaluate adult patient or caregiver feelings and viewpoints about sudden unexpected death in epilepsy (SUDEP) awareness.

Background: The decision to discuss SUDEP with patients and families has created much debate. Many healthcare providers (HCPs) are hesitant to discuss SUDEP because of the perception of evoking unnecessary fear in patients while others argue that informing patients about SUDEP may enhance patient compliance, improve seizure control, and aid in saving lives. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.06.026DOI Listing
September 2018
2 Reads

Editorial: Sudden Death in Epilepsy: Basic and Translational Research.

Front Neurol 2018 27;9:484. Epub 2018 Jun 27.

UCLA Department of Neurology, Olive View-UCLA Medical Center, David Geffen-UCLA School of Medicine, Los Angeles, CA, United States.

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http://dx.doi.org/10.3389/fneur.2018.00484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030357PMC

Effect of providing sudden unexpected death in epilepsy (SUDEP) information to persons with epilepsy (PWE) and their caregivers-Experience from a tertiary care hospital.

Acta Neurol Scand 2018 Nov 9;138(5):417-424. Epub 2018 Jul 9.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Objective: The primary objective of present study was to observe the effect of providing SUDEP (Sudden Unexpected Death in Epilepsy) information on drug adherence in persons with epilepsy (PWE). We also looked at impact of disclosing SUDEP information on patient's quality of life and mood.

Material And Methods: This prospective study had a pretest/post-test design. Read More

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http://dx.doi.org/10.1111/ane.12994DOI Listing
November 2018
15 Reads
2.400 Impact Factor

Tolerability of a comprehensive cardiorespiratory monitoring protocol in an epilepsy monitoring unit.

Epilepsy Behav 2018 Aug 30;85:173-176. Epub 2018 Jun 30.

Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA; Veterans Affairs Medical Center, 601 Hwy 6 West, Iowa City, IA 52246, USA. Electronic address:

Background: Recent reports of fatal or near-fatal events in epilepsy monitoring units (EMUs) and an increasing awareness of the effects of seizures on breathing have stimulated interest in cardiorespiratory monitoring for patients undergoing video-electroencephalography (EEG) recording. Patient and provider acceptance of these extra recording devices has not previously been studied and may represent a barrier to widespread adoption.

Methods: We queried EMU subjects regarding their experiences with a monitoring protocol that included the continuous measurement of oral/nasal airflow, respiratory effort (chest and abdominal respiratory inductance plethysmography), oxygen saturation, and transcutaneous CO. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214684PMC
August 2018
13 Reads

Causes of mortality in early infantile epileptic encephalopathy: A systematic review.

Epilepsy Behav 2018 Aug 13;85:32-36. Epub 2018 Jun 13.

Brain Institute of Rio Grande do Sul (BraIns), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil; CNPq, Brazil. Electronic address:

Introduction: Early infantile epileptic encephalopathy syndrome (EIEE), also known as Ohtahara syndrome, is an age-dependent epileptic encephalopathy syndrome defined by clinical features and electroencephalographic findings. Epileptic disorders with refractory seizures beginning in the neonatal period and/or early infancy have a potential risk of premature mortality, including sudden death. We aimed to identify the causes of death in EIEE and conducted a literature survey of fatal outcomes. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.05.015DOI Listing
August 2018
11 Reads