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Clin Res Cardiol 2019 Mar 16. Epub 2019 Mar 16.

First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Background: Short QT syndrome (SQTS) is associated with sudden cardiac death and implantable cardioverter-defibrillator (ICD) implantation is recommended in this rare disease. However, only a few SQTS families have been reported in literature with limited follow-up data.

Objectives: In the recent study, we describe the outcome data of 57 SQTS patients receiving ICD implantation. Read More

Forensic Sci Int 2019 Feb 27;298:80-87. Epub 2019 Feb 27.

Departments of Pediatrics, NYU School of Medicine, New York, NY 10016 USA; Departments of Physiology & Neuroscience NYU School of Medicine, New York, NY 10016 USA; Departments of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY 10016 USA. Electronic address:

Background: Genetic variation in ion channel genes ('channelopathies') are often associated with inherited arrhythmias and sudden death. Genetic testing ('molecular autopsies') of channelopathy genes can be used to assist in determining the likely causes of sudden unexpected death. However, different in silico approaches can yield conflicting pathogenicity predictions and assessing their impact on ion channel function can assist in this regard. Read More

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Fondazione Gabriele Monasterio CNR/Regione Toscana, Pisa, Italy. Electronic address:

Objectives: The objective of this meta-analysis was to assess the predictive value of late gadolinium enhancement (LGE) and global systolic impairment for future major adverse cardiovascular events in left ventricular noncompaction (LVNC).

Background: The prognosis of patients with LVNC, with and without left ventricular dysfunction and LGE, is still unclear.

Methods: A systematic review of published research and a meta-analysis reporting a combined endpoint of hard (cardiac death, sudden cardiac death, appropriate defibrillator firing, resuscitated cardiac arrest, cardiac transplantation, assist device implantation) and minor (heart failure hospitalization and thromboembolic events) events was performed. Read More

J Mol Cell Cardiol 2019 Mar 13. Epub 2019 Mar 13.

Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Italy; IRCCS Neuromed, Pozzilli (Isernia), Italy. Electronic address:

Aortic valve stenosis (AS) is the most common heart valve disease in North America and Europe leading to an increased risk of heart failure and death. A multidisciplinary evaluation of symptoms, individual risk profile, echocardiographic parameters, biomarkers assessment is required for an appropriate clinical and therapeutic management of AS. The natriuretic peptides (NPs) represent an important biomarker for diagnostic, prognostic and therapeutic purposes in several cardiovascular diseases. Read More

Stem Cell Res 2019 Mar 6;36:101416. Epub 2019 Mar 6.

Coronary Care Unit and Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Department of Molecular Medicine, Unit of Cardiology, Università degli studi di Pavia, Pavia, Italy.; Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

We generated human induced pluripotent stem cells (hiPSCs) from a symptomatic Long QT Syndrome (LQTS) type 1 patient, belonging to a South African (SA) founder population segregating the heterozygous mutation c.1022C > T p.A341V on the KCNQ1 gene. Read More

Turk Kardiyol Dern Ars 2019 Mar;47(2):122-127

Department of Cardiovascular Surgery, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.

Objective: A study of the T wave peak-to-end (Tp-e) interval, the Tp-e/QT ratio, and the Tp-e/QTc ratio in pediatric heart transplant recipients (HTRs), a group which has a higher risk of sudden cardiac death than the normal population, has not previously been reported. The aim of this study was to assess alterations in ventricular repolarization using the Tp-e interval, Tp-e/ QT ratio, and Tp-e/QTc ratio in clinically stable pediatric HTRs.

Methods: A total of 13 clinically stable HTRs, 13 patients who had undergone cardiac surgery (CS) under cardiopulmonary bypass, and 16 healthy controls under 18 years of age were retrospectively evaluated. Read More

Pacing Clin Electrophysiol 2019 Mar 15. Epub 2019 Mar 15.

Paris Cardiovascular Research Centre, Inserm, U 970, Paris.

A 52-year-old man, resuscitated from sudden cardiac arrest of unknown etiology, considered to be idiopathic ventricular fibrillation (VF), received a Boston Scientific Autogen VR DF-4 single-chamber implantable cardioverter defibrillator (ICD) with a single-coil, integrated-bipolar lead (Boston Scientific, Reliance 0292) positioned at the right ventricular apex. Maximum ventricular sensitivity was set at 0.3 mV with Automatic Gain Control (AGC) on. Read More

Front Physiol 2019 25;10:144. Epub 2019 Feb 25.

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Sudden Cardiac Death (SCD) is the leading cause of cardiovascular death in dialysis patients. This review discusses potential underlying arrhythmic mechanisms of SCD in the dialysis population. It examines recent evidence from studies using implantable loop recorders and from electrophysiological studies in experimental animal models of chronic kidney disease. Read More

Diabetes Res Clin Pract 2019 Mar 11. Epub 2019 Mar 11.

Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

Aims: To investigate prognostic significance of post-exercise recovery of rate-pressure product (RPP) in patients with stable coronary artery disease (CAD) and type 2 diabetes (T2D).

Methods: Patients with angiographically documented CAD and T2D (n=697) underwent symptom-limited bicycle exercise test. Exercise capacity (EC), heart rate, blood pressure and RPP responses to peak exercise and recovery (2' and 5' after cessation of exercise) were analyzed. Read More

Vet Clin North Am Equine Pract 2019 Mar 11. Epub 2019 Mar 11.

Section of Imaging, Department of Clinical Studies, New Bolton Center, University of Pennsylvania, 382 West Street Road, Kennett Square, PA 19348, USA. Electronic address:

Arrhythmias detected on prepurchase examination should be confirmed with an ECG. Exercising ECG determines if the arrhythmia is overdriven during exercise or is a safety concern. An echocardiogram is needed in all horses with a grade 3/6 or louder mid to late systolic, holosystolic, or pansystolic murmur or any holodiastolic decrescendo murmur to identify the cardiac abnormality and its hemodynamic impact. Read More

Vet Clin North Am Equine Pract 2019 Mar 11. Epub 2019 Mar 11.

Equine Sports Medicine Consultants, LLC, 40 East Main Street, Suite 232, Newark, DE 19711, USA. Electronic address:

Horses have a high prevalence of resting arrhythmias, cardiac murmurs, and valvular regurgitation, and training can increase the prevalence. This makes it challenging for equine veterinarians who are asked to evaluate horses for poor performance to determine the clinical relevance of some findings. In addition, cardiac disease has the potential to cause collapse or sudden death, putting both the horse and rider at risk. Read More

J Am Coll Cardiol 2019 Mar;73(10):1233-1234

Circ Heart Fail 2019 Mar;12(3):e005371

Division of Cardiovascular Medicine, Department of Medicine (V.N.P., C.C., C.R., M.T.W., E.A.A.), Stanford University School of Medicine, CA.

Background Variants in the cardiomyocyte-specific RNA splicing factor RBM20 have been linked to familial cardiomyopathy, but the causative genetic architecture and clinical consequences of this disease are incompletely defined. Methods and Results To define the genetic architecture of RBM20 cardiomyopathy, we first established a database of RBM20 variants associated with cardiomyopathy and compared these to variants observed in the general population with respect to their location in the RBM20 coding transcript. We identified 2 regions significantly enriched for cardiomyopathy-associated variants in exons 9 and 11. Read More

Epilepsy Res 2019 Feb 28;152:11-17. Epub 2019 Feb 28.

Department of Pediatrics, Kosin University Gospel Hospital, Kosin University, Busan, Republic of Korea.

Purpose: This study aimed to investigate cardiac electrical and autonomic function, the longitudinal changes, and the associated risk factors in children with Dravet syndrome (DS).

Methods: Twenty-four children with DS (11 boys, 13 girls; mean age, 7.2 ± 2. Read More

Case Rep Cardiol 2019 5;2019:3907190. Epub 2019 Feb 5.

Heart Centre, King Faisal Specialist Hospital and Research Centre (KFSH&RC), Riyadh, Saudi Arabia.

Patients with complex congenital heart disease (CHD) and low left ventricular ejection fraction are at an increased risk of sudden cardiac death (SCD). Prevention of SCD by subcutaneous implantable cardioverter defibrillator (S-ICD) implantation may represent a valuable option in certain CHD patients. Patients with CHD and dextrocardia pose a challenge in S-ICD system implantation, and nonstandard device placement may be required. Read More

Circ Arrhythm Electrophysiol 2019 Mar;12(3):e007022

Department of Cardiology, Rigshospitalet (M.B.E., S.H.-H., A.A.R., J.H.S., S.P., L.V.K., J.J.T.), University of Copenhagen, Denmark.

Background Patients with nonischemic systolic heart failure are at an increased risk of sudden cardiac death, but more discriminating tools are needed to identify those patients likely to benefit from implantable cardioverter-defibrillator (ICD) implantation. Whether right ventricular (RV) ejection fraction (RVEF) can identify patients with nonischemic systolic heart failure more likely to benefit from ICD implantation is not yet known. Methods In this post hoc analysis of the DANISH trial (Danish Study to Assess the Efficacy of ICDs in Patients with Nonischemic Systolic Heart Failure on Mortality), patients with nonischemic systolic heart failure randomized to ICD or control underwent cardiovascular magnetic resonance. Read More

Circulation 2019 Mar;139(10):1259-1261

Department of Cardiology, European Hospital Geroges Pompidou, Assistance Publique Hôpitaux de Paris, Paris Descartes University, France (E.P.,C.S.).

Int J Clin Pharm 2019 Mar 12. Epub 2019 Mar 12.

Center for Drug Research and Development and Pharmacokinetic Applications (ARGEFAR), Ege University, Izmir, Turkey.

European Medicines Agency (EMA) issued a final decision on September 01, 2014 that restricts the maximum daily dose of domperidone to 30 mg and treatment duration to 7 days. This paper presents a critical review of the scientific basis of the literatures having a role in the decision of EMA on domperidone with an approach based on statistical and epidemiological perspective. Although observational studies used by EMA were published, the EMA didn't use an algorithm including "randomized clinical trials" according to evidence-based medicine when presenting their results. Read More

World J Clin Cases 2019 Mar;7(5):628-635

Department of Radiology, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Ancona 60126, Italy.

Background: The association of two congenital coronary artery anomalies (CAAs) is extremely rare but represents one of the main cause of sudden cardiac death in young athletes. Although coronary angiography (CX-A) is still widely used in childhood, cardiac magnetic resonance (C-MRI) and cardiac computed tomography (C-CT) have recently taken on an increasing diagnostic role in early detection of CAAs and concomitant congenital cardiac malformations.

Case Summary: A healthy 10-year-old male patient was referred to the Radiological Department of our Institution due to no evidence of left coronary artery in echocardiographic examination. Read More

World J Clin Cases 2019 Mar;7(5):548-561

Department of Pediatric Nephrology, Puerta del Mar University Hospital, Cadiz 11009, Spain.

Background: Myocarditis is an important cause of morbidity and mortality in children, leading to long-term sequelae including chronic congestive heart failure, dilated cardiomyopathy, heart transplantation, and death. The initial diagnosis of myocarditis is usually based on clinical presentation, but this widely ranges from the severe sudden onset of a cardiogenic shock to asymptomatic patients. Early recognition is essential in order to monitor and start supportive treatment prior to the development of severe adverse events. Read More

Eur J Prev Cardiol 2019 Jan 6:2047487318821772. Epub 2019 Jan 6.

5 Faculty of Medicine and Life Sciences, Antwerp University, Belgium.

Present cardiac prevention mainly focuses on risk reduction later in life, and focuses also mainly on reducing risk factors for coronary heart disease. However, multiple studies have gathered evidence that the development risk of cardiovascular disease starts early in life and that even preconceptional influences play an important role in lifetime risk. Therefore, the importance of well-timed prevention strategies to reduce cardiovascular disease is well established. Read More

Leg Med (Tokyo) 2019 Mar 7;38:1-4. Epub 2019 Mar 7.

DIMEC, University of Bologna, Department of Medical and Surgical Sciences, Section of Legal Medicine, 40126 Bologna, Italy.

Acute myocarditis is related to a significant number of sudden deaths among young adults and its diagnosis is often demanded to post-mortem investigations performed on a forensic setting. Eosinophilic myocarditis (EM) is a rare form of myocarditis that is pathologically characterized by myocardial inflammation with eosinophils, often in association with elevated levels of circulating blood eosinophils. The sudden death of a 19-year-old boy with no past medical history is reported. Read More

Front Physiol 2019 25;10:145. Epub 2019 Feb 25.

Department of Renal Medicine, Salford Royal NHS Foundation Trust and The University of Manchester, Manchester, United Kingdom.

Cardiovascular disease is the commonest cause of death in hemodialysis (HD) patients but accurate risk prediction is lacking. The spatial QRS - T angle is a promising electrophysiological marker for sudden cardiac death risk stratification. The aim of this study was to assess the prognostic value of spatial QRS-T angle derived from standard 12 lead electrocardiograms (ECG) and its association with echocardiographic parameters in HD patients. Read More

J Electrocardiol 2019 Feb 27;54:36-39. Epub 2019 Feb 27.

Ahmanson/UCLA Adult Congenital Heart Disease Center, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States of America. Electronic address:

Introduction: Chronic pulmonary regurgitation (PR) following surgical correction in Tetralogy of Fallot (TOF) leads to right ventricular (RV) dysfunction, arrhythmias and sudden cardiac death (SCD). Pulmonary valve replacement (PVR) decreases PR and improves RV function, but data regarding QRS duration reduction remain scarce.

Methods: All adult TOF patients undergoing transcatheter PVR or surgical PVR from 2010 to 2016 were included. Read More

Can J Physiol Pharmacol 2019 Mar 11. Epub 2019 Mar 11.

King Faisal Specialist Hospital and Research Center, 37852, Department of Genetics, , P.O. Box 3354 , 11211 , Riyadh, Saudi Arabia , 11211.

Structural dilation of cardiomyocytes (CMs) imposes a decline in cardiac performance that precipitates cardiac failure and sudden death. Since membrane proteins are implicated in dilated cardiomyopathy and heart failure, we evaluated the expression of the sarcolemmal membrane-associated protein (SLMAP) in dilated cardiomyopathy and its effect on CM contraction. We found that all three SLMAP isoforms (SLMAP-1, -2, and -3) are expressed in CMs and are downregulated in human dilated ventricles. Read More

Dtsch Arztebl Int 2019 Jan;116(4):47-53

Department of Cardiology, Klinikum Würzburg-Mitte, Juliusspital, Würzburg; Department of Thoracic and Cardiovascular Surgery, Saarland University Hospital, Homburg/Saar; University of Paris Descartes, Sorbonne Paris Cité, Paris, France.

Background: Hypertrophic cardiomyopathy (HCM) is caused by mutations in a number of genes. Its prevalence is 0.2% to 0. Read More

Heart Fail Rev 2019 Mar 9. Epub 2019 Mar 9.

2nd Cardiology Department, National and Kapodistrian University of Athens, Attikon Hospital, Rimini 1, 12462, Haidari, Greece.

Hypertrophic cardiomyopathy (HCM) represents a phenotype of left ventricular hypertrophy unexplained by abnormal loading conditions. The definition is based on clinical criteria; however, there are numerous underlying etiologic factors. The MOGE(S) classification provides a standardized approach for multimodal characterization of HCM. Read More

J Interv Card Electrophysiol 2019 Mar 9. Epub 2019 Mar 9.

Cardiology Department, Coimbra Hospital and University Centre, Coimbra, Portugal.

Background: Despite the important role of cardiac pacing in preventing syncope and sudden cardiac death in familial amyloid polyneuropathy (FAP), we lack clear guidelines as to the ideal timing and indications for permanent pacemaker implantation.

Purpose: The purpose of this study was to evaluate the ideal timing for pacemaker implantation in FAP patients submitted to liver transplantation.

Methods: Retrospective study of 258 FAP patients submitted to liver transplantation between 1992 and 2012. Read More

BMJ Case Rep 2019 Mar 9;12(3). Epub 2019 Mar 9.

Cardiology, Albany Medical Center Hospital, Albany, New York, USA.

A previously healthy 44-year-old Caucasian man presented with recurrent syncope and was found to have a complete heart block with a ventricular rate of 24 bpm. No biochemical abnormalities were identified. Tick borne illnesses were ruled out. Read More

Europace 2019 Mar 8. Epub 2019 Mar 8.

Department of Medicine, McMaster University, Population Health Research Institute (PHRI), 30 Birge St., Hamilton, Ontario L8L 0A6, Canada.

Aims: Hospitalizations are common among patients with atrial fibrillation. This article aimed to analyse the causes and consequences of hospitalizations occurring during the Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY) trial.

Methods And Results: The RE-LY database was used to evaluate predictors of hospitalization using multivariate regression modelling. Read More

Future Cardiol 2019 Mar 8. Epub 2019 Mar 8.

Pediatric & Grown-up Congenital Cardiac Surgery Unit, Cardiothoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Bologna, 40138, Italy.

Aim: The aim of the study was to assess predictors of outcome in patients hospitalized for dilated cardiomyopathy (DCM) and severe left ventricular dysfunction. Patients & methods: Eighty-three pediatric patients hospitalized for heart failure due to DCM with coexistent left ventricular dysfunction were enrolled.

Results: Overall, 5-year survival free from heart transplantation was 69. Read More

Herzschrittmacherther Elektrophysiol 2019 Mar 7;30(1):72-88. Epub 2019 Mar 7.

Medizinische Klinik I, Krankenhaus Landshut-Achdorf, Achdorfer Weg 3, 84036, Landshut, Deutschland.

JACC Basic Transl Sci 2019 Feb 25;4(1):83-94. Epub 2019 Feb 25.

Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland.

Myocardial infarction (MI)-induced cardiac fibrosis attenuates cardiac contractile function, and predisposes to arrhythmias and sudden cardiac death. Expression of connective tissue growth factor (CTGF) is elevated in affected organs in virtually every fibrotic disorder and in the diseased human myocardium. Mice were subjected to treatment with a CTGF monoclonal antibody (mAb) during infarct repair, post-MI left ventricular (LV) remodeling, or acute ischemia-reperfusion injury. Read More

Nat Biomed Eng 2018 Oct 3;2(10):732-740. Epub 2018 Sep 3.

Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Ventricular tachycardia (VT), which can lead to sudden cardiac death, occurs frequently in patients with myocardial infarction. Catheter-based radiofrequency ablation of cardiac tissue has achieved only modest efficacy, owing to the inaccurate identification of ablation targets by current electrical mapping techniques, which can lead to extensive lesions and to a prolonged, poorly tolerated procedure. Here we show that personalized virtual-heart technology based on cardiac imaging and computational modelling can identify optimal infarct-related VT ablation targets in retrospective animal (5 swine) and human studies (21 patients) and in a prospective feasibility study (5 patients). Read More

Circ Arrhythm Electrophysiol 2019 Mar;12(3):e006920

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (D.M.P., A.M.S., C.L., V.R.V., C.J.M., S.J.A., S.K.).

Background: Reentrant ventricular arrhythmias are a major cause of sudden death in patients with structural heart disease. Current treatments focus on electrically homogenizing regions of scar contributing to ventricular arrhythmia with ablation or altering conductive properties using antiarrhythmic drugs. The high conductivity of carbon nanotubes may allow restoration of conduction in regions where impaired electrical conduction results in functional abnormalities. Read More

Pharmacol Res 2019 Mar 4;143:27-32. Epub 2019 Mar 4.

Division of Cardiology, McGill University Health Center, Montreal, Canada. Electronic address:

Implantable cardiac defibrillators (ICD) are the foundation of therapy for the prevention of sudden cardiac death. While ICDs prevent SCD, they do not prevent the occurrence of ventricular arrhythmias which are usually symptomatic. Though catheter ablation has been successful in substrate modification of ventricular tachycardia in patients with ischemic cardiomyopathy, there is much less evidence to support its use in non-ischemic cardiomyopathy. Read More

Gene 2019 Mar 5;698:157-169. Epub 2019 Mar 5.

Post-Graduate Program in Cardiology and Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Heart Failure and Cardiac Transplant Unit, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.

Pathological cardiac hypertrophy (CH) is associated with increased heart failure risk and sudden cardiac death. Several transcription factors (TFs) and miRNAs were implicated in CH, and their high combinatorial action in gene expression regulation is becoming more clear. We adopted a systems biology approach to construct a comprehensive TF-miRNA co-regulatory network in CH and systematically characterize its structure, from node- to systems-level properties. Read More

J Cardiovasc Electrophysiol 2019 Mar 6. Epub 2019 Mar 6.

Section of Cardiac Electrophysiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Mitral valve prolapse (MVP) is a common valve condition and has been associated with sudden cardiac death. Premature ventricular contractions (PVCs) from the papillary muscles (PMs) may play a role as triggers for ventricular fibrillation (VF) in these patients.

Objectives: To characterize the electrophysiological substrate and outcomes of catheter ablation in patients with MVP and PM PVCs. Read More

Ment Health Clin 2019 Mar 1;9(2):93-99. Epub 2019 Mar 1.

Pharmacy Librarian, Marshall B. Ketchum University, MB Ketchum Memorial Library, Fullerton, California.

Introduction: Synthetic cannabinoids (SCs) are psychoactive substances that are gaining popularity for their availability and lack of detection by standardized drug tests. Although some users may perceive SCs as safer alternatives to marijuana, some SCs are more potent and result in more severe toxicities.

Methods: A search of the literature was conducted in the PubMed and SciFinder databases. Read More

Ment Health Clin 2019 Mar 1;9(2):82-87. Epub 2019 Mar 1.

Pharmacy Resident, Barnabas Health Behavioral Health Center, Toms River, New Jersey; Ernest Mario School of Pharmacy at Rutgers, The State University of New Jersey, New Brunswick, New Jersey.

Introduction: Many medications commonly prescribed in psychiatric hospitals can cause QTc-interval prolongation, increasing a patient's risk for torsades de pointes and sudden cardiac death. There is little guidance in the literature to determine when an electrocardiogram (ECG) and QTc-interval monitoring should be performed. The primary end point was improvement of the appropriateness of ECGs and QTc-interval monitoring of at-risk psychiatric inpatients at Barnabas Health Behavioral Health Center (BHBH) and Monmouth Medical Center (MMC) following implementation of a standardized monitoring protocol. Read More

J R Coll Physicians Edinb 2019 Mar;49(1):26-30

Queen Elizabeth University Hospital, Glasgow, UK.

Diagnosis of inherited arrhythmia syndromes, including long-QT syndrome (LQTS), is challenging; however, early detection and initiation of therapies can reduce otherwise high rates of mortality. Two months following the birth of her first child a previously well 21-year-old female experienced four episodes of transient loss of consciousness (TLOC). The history was atypical for seizures but a video electroencephalogram (EEG) captured an episode with abnormal bifrontal epileptic discharge. Read More

J Endocrinol Invest 2019 Mar 5. Epub 2019 Mar 5.

Department of Experimental and Clinical Medicine, University of Catanzaro  « Magna Grecia », Catanzaro, Italy.

Background And Aim: Evidences suggest that androgen deficiency is associated with sudden cardiac death (SCD). Our purpose was to analyse some electrocardiographic (ECG) markers of repolarization phase in hypogonadal patients either at baseline or after testosterone replacement therapy (TRT).

Patients And Methods: Baseline and after 6 months of testosterone replacement therapy, 14 hypogonadal patients and 10 age-matched controls underwent a short-term ECG recordings at rest and immediately after a maximal exercise test. Read More

Front Physiol 2019 19;10:103. Epub 2019 Feb 19.

Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China.

with Brugada syndrome (BrS) is not commonly considered as an independent risk marker for subsequent cardiac events. However, the risk of combined with other clinical characteristics has not been fully investigated. The aim of this study is to investigate and evaluate risk stratification and related risk factors of in BrS. Read More

Eur Heart J Suppl 2019 Feb 26;21(Suppl A):A2-A5. Epub 2019 Feb 26.

Institute of Clinical Medicine, Copenhagen University, Blegdamsvej 3B, Copenhagen, Denmark.

Determination of potassium level is one of the most frequent laboratory tests in clinical medicine. Hyperkalaemia is defined as a potassium level >5.0 mmol/L and is one of the most clinically important electrolyte abnormalities, because it may cause dangerous cardiac arrhythmia and sudden cardiac death. Read More

Assay Drug Dev Technol 2019 Mar 5. Epub 2019 Mar 5.

1 Integrated Drug Discovery, High-Content Biology, Sanofi Research and Development, Vitry-sur-Seine, France.

Inwardly rectifying I potassium currents of the heart control the resting membrane potential of ventricular cardiomyocytes during diastole and contribute to their repolarization after each action potential. Mutations in the gene encoding K2.1 channels, which primarily conduct ventricular I, are associated with inheritable forms of arrhythmias and sudden cardiac death. Read More

Tex Heart Inst J 2019 02 1;46(1):41-43. Epub 2019 Feb 1.

Loeys-Dietz syndrome is a genetic disorder that predisposes patients to aortic aneurysms. If left untreated, the natural history of the associated aortopathy often culminates in fatal aortic dissection. We describe the case of a 21-year-old man who was diagnosed with Loeys-Dietz syndrome after 2 family members died of aortic dissection. Read More

BMC Cancer 2019 Mar 4;19(1):195. Epub 2019 Mar 4.

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: Chemoradiotherapy effectively treats superficial esophageal cancer and is optimal to preserve organs. However, late toxicity, particularly in cardiac diseases, obstructs clinical outcomes. We revealed the risk factors for cardiac event development post-chemoradiotherapy. Read More

Resuscitation 2019 Mar 1;138:36-41. Epub 2019 Mar 1.

Armed Forces Medical Centre Ulm, Department of Anaesthesiology & Intensive Care Medicine, Section Emergency Medicine, Ulm, Germany.

Aim: In terms of treatment options, the underlying cause of out-of-hospital cardiac arrest (OHCA) has an impact on survival. This study aimed to examine the frequencies of different causes of OHCA and their outcomes using data from a national resuscitation registry.

Methods: All pre-hospital cardiopulmonary resuscitations (CPR) documented in the German Resuscitation Registry between 2007 and 2017 were retrospectively investigated with regard to cause of cardiac arrest, return of spontaneous circulation (ROSC), and hospital discharge rate with good neurological outcome. Read More