5,570 results match your criteria Substance-Induced Mood Disorders Depression and Mania


Efficacy, acceptability and tolerability of antipsychotics in patients with schizophrenia and comorbid substance use. A systematic review and meta-analysis.

Eur Neuropsychopharmacol 2018 Nov 21. Epub 2018 Nov 21.

Department of Psychiatry and Psychotherapy, Technical University of Munich, Klinikum rechts der Isar, Ismaningerstraße 22, 81675 Munich, Germany.

Patients with schizophrenia and substance related comorbidity or substance induced psychotic disorder are difficult to treat. Although the prevalence of a comorbid substance use is approximately 40% in schizophrenia, such patients are usually excluded from clinical trials. We therefore performed a random-effects meta-analysis of all randomized controlled antipsychotic drug trials in this patient subgroup. Read More

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November 2018
1 Read

Characteristics and outcomes of young people with substance induced psychotic disorder.

Schizophr Res 2018 Nov 21. Epub 2018 Nov 21.

Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia; Centre for Youth Mental Health, University of Melbourne, Australia; Orygen Youth Health, 35 Poplar Rd, Parkville, VIC 3025, Australia. Electronic address:

Background: Substance induced psychotic disorders (SIPD) have been historically considered as associated with better clinical and functional outcomes than other psychotic diagnoses. As a result, treatments for those with SIPD are often considerably less intensive, yet this is not based on evidence. The present study aimed to examine whether differences exist between those with SIPD and other first episode psychosis (FEP) diagnoses in regards to demographic and clinical factors, and to determine the symptomatic, clinical and functional outcomes in those with SIPD. Read More

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November 2018
8 Reads

Resilience to Risk for Psychopathology: The Role of White Matter Microstructural Development in Adolescence.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 Aug 27. Epub 2018 Aug 27.

Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon; Department of Psychiatry, Oregon Health and Science University, Portland, Oregon. Electronic address:

Background: One major risk factor for the development of psychopathology is a family history of psychopathology (FHP). Cross-sectional studies have shown that FHP is associated with alterations in white matter microstructure in adolescents without current psychopathology; however, whether these associations persist throughout adolescence, particularly in those who remain resilient to developing psychopathology, is unclear.

Methods: Sixty-six adolescents underwent diffusion-weighted imaging at baseline (12-16 years of age) and at one or two follow-up visits (142 total scans). Read More

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August 2018
1 Read

An early warning system for emerging drugs of concern in the emergency department: Protocol for the Western Australian Illicit Substance Evaluation (WISE) study.

Emerg Med Australas 2018 Oct 14. Epub 2018 Oct 14.

Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia.

Objective: An ever-increasing number of novel psychoactive substances are being detected worldwide. These emerging drugs have been demonstrated to cause toxicity in clusters, and deaths have been reported. We urgently need to learn more about their effects. Read More

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October 2018
1 Read

Predictors of resistant alcohol withdrawal (RAW): A retrospective case-control study.

Drug Alcohol Depend 2018 Nov 2;192:303-308. Epub 2018 Oct 2.

Department of Pharmacy, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, United States; Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, 3501 Terrace St, Pittsburgh, PA 15213, United States.

Background: Benzodiazepine-resistant alcohol withdrawal (RAW), defined by a requirement of ≥ 40 mg of diazepam in 1 h, represents a severe form of withdrawal without predictive parameters. This study was designed to identify risk factors associated with RAW versus withdrawal without benzodiazepine resistance (nRAW).

Methods: A retrospective cohort of adults with severe alcohol withdrawal were screened. Read More

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November 2018
8 Reads
3.420 Impact Factor

Indexing the 'dark side of addiction': substance-induced affective symptoms and alcohol use disorders.

Addiction 2018 Aug 28. Epub 2018 Aug 28.

Departments of Genetics and Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background And Aims: The emergence of negative affective symptoms during the course of alcohol use disorders (AUDs) (e.g. 'dark side' symptoms) has been suggested theoretically; however, the description of their occurrence is limited. Read More

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August 2018
6 Reads

Electro-acupuncture improves psychiatric symptoms, anxiety and depression in methamphetamine addicts during abstinence: A randomized controlled trial.

Medicine (Baltimore) 2018 Aug;97(34):e11905

Department of Genetics, Rutgers University, New Jersey.

Background: It aimed to observe the effect of electro-acupuncture on the improvement of psychiatric symptoms, as well as anxiety and depression in methamphetamine (MA) addicts during abstinence using randomized controlled trials.

Methods: All patients in the present study received compulsory drug detoxification in Shanghai Drug Rehabilitation Center. All patients were enrolled consecutively from June 2014 to February 2015; data collection was completed in March 2015. Read More

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August 2018
8 Reads

A case of Capgras syndrome and folie à duex in monozygotic twins.

Neurocase 2018 Jun 24;24(3):175-179. Epub 2018 Aug 24.

a Psychiatric Centre Copenhagen , Copenhagen University Hospital , Copenhagen , Denmark.

Both Capgras syndrome and folie à deux (insanity of two) are rare and fascinating psychopathological syndromes. Their etiology and the nosological position remain unclear. We present a case of substance-induced Capgras syndrome emerging as folie à deux (insanity of two) in monozygotic twins with strongly overlapping life histories. Read More

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June 2018
17 Reads

[Incidence and treatment of non-substance-induced delirium in general and specialist practices in Germany].

Fortschr Neurol Psychiatr 2018 Oct 10;86(10):616-623. Epub 2018 Aug 10.

Epidemiologie, IQVIA, Frankfurt, Germany.

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October 2018
8 Reads

Misuse of sibutramine and bulimia nervosa: a dangerous combination.

Braz J Psychiatr 2018 Jul-Sep;40(3):343

Grupo de Obesidade e Transtornos Alimentares (GOTA), Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

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August 2018
1 Read

The prevalence of substance-induced psychotic disorder in methamphetamine misusers: A meta-analysis.

Psychiatry Res 2018 Oct 17;268:189-192. Epub 2018 May 17.

Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry, Faculty of Medicine, University of Montreal, Montreal, Canada. Electronic address:

There is little consensus regarding the prevalence of methamphetamine-induced psychotic disorder (MIPD). A search of the literature was performed, effect size estimates were calculated with event rates and were aggregated with a random-effects model. Seventeen studies were included in the meta-analysis, resulting in a composite event rate of 36. Read More

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October 2018
9 Reads

Attention-Deficit Hyperactivity Disorder in Adults Using Methamphetamine: Does It Affect Comorbidity, Quality of Life, and Global Functioning?

Iran J Psychiatry 2018 Apr;13(2):111-118

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Attention-deficit hyperactivity disorder (ADHD) is common in adulthood, and it is associated with different high- risk behaviors, particularly substance use. Evidence suggests a high prevalence of ADHD in adults who take methamphetamine (METH). This study aimed at comparing functional level, quality of life, and psychiatric comorbidities in METH users with and without adult ADHD (A-ADHD). Read More

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Expert-based controllability assessment of control transitions from automated to manual driving.

MethodsX 2018 19;5:579-592. Epub 2018 May 19.

BMW AG, Germany.

Up to a level of full vehicle automation, drivers will have to be available as a fallback level and take back manual control of the vehicle in case of system limits or failures. Before introducing automated vehicles to the consumer market, the controllability of these control transitions has to be demonstrated. This paper presents a novel procedure for an expert-based controllability assessment of control transitions from automated to manual driving. Read More

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May 2018
7 Reads

Glutamatergic Deficits in Schizophrenia - Biomarkers and Pharmacological Interventions within the Ketamine Model.

Curr Pharm Biotechnol 2018 ;19(4):293-307

Psychiatry Neuroimaging Branch (PNB), Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: The observation that N-methyl-D-aspartate glutamate receptor (NMDAR) antagonists such as ketamine transiently induce schizophrenia-like positive, negative and cognitive symptoms has led to a paradigm shift from dopaminergic to glutamatergic dysfunction in pharmacological models of schizophrenia. NMDAR hypofunction can explain many schizophrenia symptoms directly due to excitatory-to-inhibitory (E/I) imbalance, but also dopaminergic dysfunction itself. However, so far no new drug targeting the NMDAR has been successfully approved. Read More

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October 2018
9 Reads

Changes in Gray Matter Density, Regional Homogeneity, and Functional Connectivity in Methamphetamine-Associated Psychosis: A Resting-State Functional Magnetic Resonance Imaging (fMRI) Study.

Med Sci Monit 2018 Jun 13;24:4020-4030. Epub 2018 Jun 13.

Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Institute of Forensic Science, Ministry of Justice, Shanghai, China (mainland).

BACKGROUND Using regional homogeneity (ReHo) blood oxygen level-dependent functional MR (BOLD-fMRI), we investigated the structural and functional alterations of brain regions among patients with methamphetamine-associated psychosis (MAP). MATERIAL AND METHODS This retrospective study included 17 MAP patients, 16 schizophrenia (SCZ) patients, and 18 healthy controls. Informed consent was obtained from all patients before the clinical assessment, the severity of clinical symptoms was evaluated prior to the fMRI scanning, and then images were acquired and preprocessed after each participant received 6-min fRMI scanning. Read More

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June 2018
2 Reads

Case 5: Acute Behavioral Changes in a 17-year-old Girl.

Pediatr Rev 2018 Jun;39(6):314

Khoo Teck Puat-National University Children's Medical Institute, National University Health Systems, Singapore.

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Substance-induced anxiety disorder after one dose of 3,4-methylenedioxymethamphetamine: a case report.

J Med Case Rep 2018 May 25;12(1):142. Epub 2018 May 25.

Swedish First Hill Family Medicine Residency, Swedish Medical Center, 1401 Madison Street, Suite 100, Seattle, WA, 98104, USA.

Background: In this report, we describe a case of a patient with substance-induced anxiety disorder occurring after a single dose of 3,4-methylenedioxymethamphetamine. Furthermore, we describe the use and efficacy of the Primary Care Behavioral Health model, a collaborative approach to integrative primary mental health care, in evaluating and treating this rare mental health disorder.

Case Presentation: Three days following ingestion of one dose of 3,4-methylenedioxymethamphetamine, a 35-year-old Hispanic man with no significant prior mental health history and no history of prior 3,4-methylenedioxymethamphetamine use presented to our hospital with severe, acute anxiety and panic symptoms. Read More

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May 2018
9 Reads

First Presentation with Psychotic Symptoms to the Emergency Department.

J Emerg Med 2018 07 10;55(1):78-86. Epub 2018 May 10.

Department of Emergency Medicine, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa; Department of Psychiatry, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Mental health conditions account for 52.8 million (4.9-6. Read More

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July 2018
4 Reads

A New Machine Learning Framework for Understanding the Link Between Cannabis Use and First-Episode Psychosis.

Stud Health Technol Inform 2018 ;248:9-16

MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.

Lately, several studies started to investigate the existence of links between cannabis use and psychotic disorders. This work proposes a refined Machine Learning framework for understanding the links between cannabis use and 1st episode psychosis. The novel framework concerns extracting predictive patterns from clinical data using optimised and post-processed models based on Gaussian Processes, Support Vector Machines, and Neural Networks algorithms. Read More

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June 2018
7 Reads

Amantadine in Chinese 'Cold and Flu' tablets: the cause of psychosis in a healthy man.

Intern Med J 2018 05;48(5):601-602

General Medicine, The Canberra Hospital, Canberra, Australian Capital Territory, Australia.

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May 2018
2 Reads

Relationship between the duration of methamphetamine use and psychotic symptoms: A two-year prospective cohort study.

Drug Alcohol Depend 2018 06 22;187:363-369. Epub 2018 Apr 22.

National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, 100191, China; Institute of Mental Health, National Clinical Research Center for Mental Disorders, Key Laboratory of Mental Health and Peking University Sixth Hospital, Peking University, Beijing, 100191, China; Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100191, China. Electronic address:

Background: Psychosis is a key harm associated with methamphetamine (MA) use. This study examined the relationship between the duration of MA use and risk of psychotic symptoms.

Methods: A cohort of 528 individuals with chronic MA use was followed for two years after leaving treatment center in Guangdong, China. Read More

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June 2018
4 Reads

Attempting to stop antipsychotic medication: success, supports, and efforts to cope.

Soc Psychiatry Psychiatr Epidemiol 2018 Jul 23;53(7):745-756. Epub 2018 Apr 23.

School of Psychology, The University of Auckland, Auckland, New Zealand.

Purpose: To explore supports and coping strategies used during attempts to discontinue antipsychotic medication and test for associations with success.

Method: 144 people who were taking or had taken antipsychotics completed The Experiences of Antipsychotic Medication Survey. Among them, 105 people had made at least one discontinuation attempt and answered a series of questions about their most recent attempt to stop. Read More

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Rates and features of methamphetamine-related presentations to emergency departments: An integrative literature review.

J Clin Nurs 2018 Jul 28;27(13-14):2569-2582. Epub 2018 May 28.

School of Health, University of New England, Armidale, NSW, Australia.

Aims And Objectives: To review the clinical impact methamphetamine has on emergency departments by assessing the available research on the rates and features of methamphetamine-related presentations.

Background: Globally, methamphetamine availability, distribution and use have rapidly increased. As a result, the number of methamphetamine-related presentations to emergency departments has also increased. Read More

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July 2018
1 Read

Isotretinoin: the ups are just as troubling as the downs.

G Ital Dermatol Venereol 2018 Aug 18;153(4):535-539. Epub 2018 Apr 18.

Department of Psychiatry, Dell Medical School, University of Texas at Austin, Austin, TX, USA -

Introduction: Isotretinoin, previously marketed as Accutane®, is an oral retinoid medication that is used to treat acne and other cutaneous disorders. Although the data is conflicting, previous reports suggest a causal relationship between isotretinoin and depression. When reviewing these previous reports, many patients who were diagnosed as "depressed" did not undergo a thorough psychiatric evaluation and/or were not diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM). Read More

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August 2018
3 Reads

Substance-Induced Psychosis: An Indicator of Development of Primary Psychosis?

Authors:
Subroto Ghose

Am J Psychiatry 2018 04;175(4):303-304

From the Department of Psychiatry, UTSouthwestern Medical Center, Dallas.

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April 2018
1 Read

Baby or bathwater? Referrals of "non-cases" in a targeted early identification intervention for psychosis.

Soc Psychiatry Psychiatr Epidemiol 2018 Jul 14;53(7):757-761. Epub 2018 Mar 14.

Prevention and Early Intervention Program for Psychoses, Douglas Mental Health University Institute, Verdun, Canada.

Purpose: To explore the unintended impact of a targeted case identification (TCI) campaign for first episode psychosis (FEP) on people not experiencing FEP ("non-cases") with respect to referral patterns and reasons for being a non-case.

Methods: Sources of referral, reasons for being a non-case, and subsequent referral destinations of non-cases were examined before and after a TCI.

Results: Following the TCI, a greater proportion of non-cases lived outside the study catchment area. Read More

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Methamphetamine psychosis: insights from the past.

Authors:
Rebecca McKetin

Addiction 2018 Aug 8;113(8):1522-1527. Epub 2018 Mar 8.

National Drug Research Institute, Curtin University, Perth, Australia.

Background And Aims: To review early case reports and experimental inductions of amphetamine and methamphetamine psychosis, prior to the prohibition of these drugs, to gain a better understanding of the nature and aetiology of methamphetamine psychosis.

Methods: Papers considered were historical case reports and case series of psychosis relating to the use and misuse of prescription amphetamine, focusing upon papers by Young & Scoville (1938), Connell (1958), and three subsequent experimental studies published in the early 1970s (Griffith 1972, Angrist & Gershon 1970 and Bell 1973), where psychosis was induced in volunteers using high-dose amphetamine and methamphetamine.

Results: High-dose methamphetamine and amphetamine can result in a paranoid psychosis which remits rapidly (within days) of discontinuing use. Read More

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August 2018
3 Reads

[Service Use of an Early Intervention Centre, Clinical and Sociodemographic Characteristics of Young Adults with Early Psychosis with and without Migration Background].

Psychiatr Prax 2018 Mar 7. Epub 2018 Mar 7.

Frühinterventions- und Therapiezentrum - FRITZ am Urban, Vivantes Klinikum Am Urban, Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Akademisches Lehrkrankenhaus der Charité Medizin, Berlin.

Background: The present study evaluated service use of our newly established Early Intervention and Treatment Centre (FRITZ) in Berlin for young adults with first or early psychosis with and without migration background.

Methods: We conducted a retrospective chart review of in-patients with early psychosis who were admitted to FRITZ between May 2014 and May 2015. We investigated the proportion of patients with migration background, sociodemographic and clinical characteristics of patients. Read More

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Combined NMDA Inhibitor Use in a Patient With Multisubstance-induced Psychotic Disorder.

J Addict Med 2018 May/Jun;12(3):247-251

NESMOS Department, School of Medicine and Psychology, Sapienza University, Rome, Italy (MC, GC, EdP, ER, GDK, PG); Pavia Poison Control Center, National Toxicology Information Center and Clinical-Toxicological Coordinating Center of the National Early Warning System, IRCCS Maugeri Foundation, Pavia, Italy (DL, CAL); Toxicology Laboratory, IRCCS Policlinico San Matteo Foundation, Pavia, Italy (PP); School of Life and Medical Sciences, University of Hertfordshire, Hatfield, Hertfordshire, UK (FS).

: Novel psychoactive substance use is a major social concern. Their use may elicit or uncover unpredictably as yet undescribed clinical pictures. We aimed to illustrate a multisubstance use case indistinguishable from paranoid schizophrenia, so to alert clinicians on possibly misdiagnosing substance-induced psychotic disorders. Read More

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February 2018
13 Reads
1.700 Impact Factor

Pro-psychotic effects of synthetic cannabinoids: interactions with central dopamine, serotonin, and glutamate systems.

Drug Metab Rev 2018 Feb 31;50(1):65-73. Epub 2018 Jan 31.

a Department of Pharmacology and Toxicology , University of Arkansas for Medical Sciences, College of Medicine , Little Rock , AR , USA.

An association between marijuana use and schizophrenia has been noted for decades, and the recent emergence of high-efficacy synthetic cannabinoids (SCBs) as drugs of abuse has lead to a growing number of clinical reports of persistent psychotic effects in users of these substances. The mechanisms underlying SCB-elicited pro-psychotic effects is unknown, but given the ubiquitous neuromodulatory functions of the endocannabinoid system, it seems likely that agonist actions at cannabinoid type-1 receptors (CB1Rs) might modulate the functions of other neurotransmitter systems known to be involved in schizophrenia. The present review surveys what is currently known about the interactions of CB1Rs with dopamine, serotonin, and glutamate systems, because all three of those neurotransmitters are well-established in the pathophysiology of schizophrenia and psychosis. Read More

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February 2018
9 Reads

Gene variants and educational attainment in cannabis use: mediating role of DNA methylation.

Transl Psychiatry 2018 01 22;8(1):23. Epub 2018 Jan 22.

Department of Chemistry, Life Science and Environmental Sustainability, University of Parma, Parma, Italy.

Genetic and sociodemographic risk factors potentially associated with cannabis use (CU) were investigated in 40 cannabis users and 96 control subjects. DNA methylation analyses were also performed to explore the possibility of epigenetic changes related to CU. We conducted a candidate gene association study that included variants involved in the dopaminergic (ANKK1, NCAM1 genes) and endocannabinoid (CNR1, CNR2 gene) pathways. Read More

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January 2018
1 Read

A systematic review of risk factors for methamphetamine-associated psychosis.

Aust N Z J Psychiatry 2018 Jun 16;52(6):514-529. Epub 2018 Jan 16.

1 Turning Point, Eastern Health, Fitzroy, VIC, Australia.

Objective: Chronic methamphetamine use is commonly associated with the development of psychotic symptoms. The predictors and correlates of methamphetamine-associated psychosis are poorly understood. We sought to systematically review factors associated with psychotic symptoms in adults using illicit amphetamine or methamphetamine. Read More

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June 2018
1 Read

[Diagnosis, differential diagnosis and therapy of substance use disorders in general hospital (general section)].

Neuropsychiatr 2018 Jun 11;32(2):57-68. Epub 2018 Jan 11.

UniversitätsSpital Zürich, Klinik für Psychiatrie und Psychotherapie, Abteilung für Konsiliar- und Liaisonpsychiatrie, Universität Zürich, Rämistraße 100, 8091, Zürich, Schweiz.

Substance use disorders are becoming an increasingly significant problem in general hospitals and hence play a key role in consultation- and liaison psychiatry. Diverse psychotropic effects of various substances mimic psychiatric disorders. An alcohol intoxication can present depressive or manic symptoms, a cannabis delirium can present as a psychosis while stimulants use can suggest the diagnosis of an anxiety disorder. Read More

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June 2018
6 Reads

Cannabis, cannabinoids, and health.

Dialogues Clin Neurosci 2017 Sep;19(3):309-316

Author affiliations: AP-HP, GH Paris-Sud, Hopital Paul Brousse, Dpt Addictologie, F94800 Villejuif, France; INSERM U1178, F94800 Villejuif, France.

Cannabis (also known as marijuana) is the most frequently used illicit psychoactive substance in the world. Though it was long considered to be a "soft" drug, studies have proven the harmful psychiatric and addictive effects associated with its use. A number of elements are responsible for the increased complications of cannabis use, including the increase in the potency of cannabis and an evolution in the ratio between the two primary components, Δ-tetrahydrocannabinol (Δ-THC) and cannabidiol (toward a higher proportion of Δ-THC), Synthetic cannabinoid (SC) use has rapidly progressed over the last few years, primarily among frequent cannabis users, because SCs provide similar psychoactive effects to cannabis. Read More

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September 2017
5 Reads

HIV prevalence among first-presentation psychotic patients.

HIV Med 2018 Apr 28;19(4):271-279. Epub 2017 Dec 28.

Department of Emergency Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Objectives: First-episode psychosis is a frequent emergency department (ED) presentation that may potentially be secondary to an underlying life-threatening HIV-related condition. The aim of this study was to determine the prevalence of HIV infection in patients presenting with a first episode of psychosis.

Methods: Medical records of 159 consecutive African, Asian, White and mixed ethnicity patients presenting to a tertiary academic hospital ED with a first episode of psychotic features were prospectively reviewed. Read More

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April 2018
6 Reads

Substance-induced psychotic symptoms in Borderline Personality Disorder among substance use disorder samples in Spain.

Psychiatry Res 2018 02 6;260:313-317. Epub 2017 Dec 6.

Addition and Dual Diagnosis Unit, Department of Psychiatry, Vall d´Hebron University Hospital-ASPB, Barcelona, Spain; Department of Psychiatry, Vall d´Hebron University Hospital, CIBERSAM, Barcelona, Spain; Department of Psychiatry, Universidad Autónoma de Barcelona, Spain.

Substance-induced psychosis (SIP) is frequent in substance use disorder patients. However, little is known about the presence of SIP in Borderline Personality Disorder (BPD) and what the risk factors for the development of SIP in this population would be. A sample of 91 BPD drug-dependent patients attending an outpatient substance use disorder unit was evaluated. Read More

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February 2018
5 Reads

Investigation of the Val158Met variant association with age of onset of psychosis, adjusting for cannabis use.

Brain Behav 2017 Nov 6;7(11):e00850. Epub 2017 Oct 6.

Department of PsychiatryUniversity of AlbertaEdmontonABCanada.

Objective: rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample.

Methods: One hundred and sixty-nine subjects with psychosis were recruited. Read More

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November 2017
20 Reads

Sexual Violence Victimization Among Youth Presenting to an Urban Emergency Department: The Role of Violence Exposure in Predicting Risk.

Health Educ Behav 2018 Aug 3;45(4):625-634. Epub 2017 Dec 3.

2 University of Michigan Injury Center, Department of Emergency Medicine, Ann Arbor, MI, USA.

Sexual violence (SV) is a widespread public health problem among adolescents and emerging adults with significant short- and long-term consequences. Young people living in urban, disadvantaged communities with high rates of violence may be especially at risk for SV victimization. Understanding interconnections between different forms of violence is critical to reducing SV risk among youth. Read More

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August 2018
6 Reads

6-Month follow-up of a case with psychosis triggered by valacyclovir.

J Chin Med Assoc 2018 02 1;81(2):187-188. Epub 2017 Dec 1.

Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. Electronic address:

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February 2018
2 Reads

Protective effects of γ-mangostin on 6-OHDA-induced toxicity in SH-SY5Y cells.

Neurosci Lett 2018 02 28;665:229-235. Epub 2017 Nov 28.

Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand.

γ-Mangostin is a xanthone with hydroxyl groups that confer the substance-free radical scavenging effects. As opposed to the other more extensively studied mangostins, scarce research has been conducted on neuroprotective effects of γ-mangostin on models of Parkinson's disease (PD). Therefore, this investigation aimed to elucidate its antioxidant and neuroprotective effects on 6-OHDA-induced toxicity in SH-SY5Y cells. Read More

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February 2018
7 Reads

Association of Environment With the Risk of Developing Psychotic Disorders in Rural Populations: Findings from the Social Epidemiology of Psychoses in East Anglia Study.

JAMA Psychiatry 2018 Jan;75(1):75-83

PsyLife Group, Division of Psychiatry, University College London, London, England.

Importance: Social determinants are important risk factors for the development of first-episode psychosis (FEP); their effects in rural areas are largely unknown.

Objective: To investigate neighborhood-level factors associated with FEP in a large, predominantly rural population-based cohort.

Design, Setting, And Participants: This study extracted data on referrals for treatment of potential FEP at 6 Early-Intervention Psychosis services from the Social Epidemiology of Psychoses in East Anglia naturalistic cohort study data set, which covered a population of more than 2 million people in a rural area in the East of England for a period of 3. Read More

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January 2018
14 Reads

Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis.

Am J Psychiatry 2018 04 28;175(4):343-350. Epub 2017 Nov 28.

From Mental Health Center Copenhagen, Copenhagen University Hospital; and the Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen and Aarhus.

Objective: The authors investigated the rates of conversion to schizophrenia and bipolar disorder after a substance-induced psychosis, as well as risk factors for conversion.

Method: All patient information was extracted from the Danish Civil Registration System and the Psychiatric Central Research Register. The study population included all persons who received a diagnosis of substance-induced psychosis between 1994 and 2014 (N=6,788); patients were followed until first occurrence of schizophrenia or bipolar disorder or until death, emigration, or August 2014. Read More

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April 2018
9 Reads

Acute Changes in Mentation in a Patient with Hepatic Cirrhosis Treated with High Doses of Dexamethasone.

Cureus 2017 Sep 10;9(9):e1675. Epub 2017 Sep 10.

Division of Clinical & Translational Research, Larkin Community Hospital.

Despite the anti-inflammatory benefits of steroids in the management of multiple medical conditions, they are associated with undesired metabolic and psychiatric side effects. We present a case of a 57-year-old Hispanic man with hepatic cirrhosis due to hepatitis C and no past medical history of psychiatric illnesses who became delirious after treatment with high doses of intravenous Dexamethasone. The patient presented to Larkin Community Hospital, USA with complaints of lower back pain requiring treatment with steroids for severe lumbar central canal stenosis. Read More

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September 2017
2 Reads

Blockade of platelet-activating factor receptor attenuates abnormal behaviors induced by phencyclidine in mice through down-regulation of NF-κB.

Brain Res Bull 2018 03 7;137:71-78. Epub 2017 Nov 7.

Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Republic of Korea. Electronic address:

Accumulating evidence suggests that neuroinflammation is one of the important etiologic factors of abusive and neuropsychiatric disorders. Platelet-activating factor (PAF) is potent proinflammatory lipid mediat1or and plays a pivotal role in neuroinflammatory disorders through the specific PAF receptor (PAF-R). Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia. Read More

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March 2018
14 Reads

Clinical characteristics of primary psychotic disorders with concurrent substance abuse and substance-induced psychotic disorders: A systematic review.

Schizophr Res 2017 Nov 5. Epub 2017 Nov 5.

DETECT Early Intervention in Psychosis Service, Avila House, Carysfort Avenue, Blackrock Business Park, Dublin, Ireland.

Background: Distinguishing between a primary psychotic disorder with concurrent substance abuse (PPD+SA) and a substance-induced psychotic disorder (SIPD) can be diagnostically challenging. We aimed to determine if these two diagnoses are clinically distinct, particularly in relation to psychopathology. In addition, we aimed to examine the specific clinical features of cannabis-induced psychotic disorder (CIPD) as compared to primary psychotic disorder with concurrent cannabis abuse (PPD+CA) and also to SIPD associated with any substance. Read More

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November 2017
25 Reads
3.920 Impact Factor

[Taxation of traditional rums in French overseas territories and public health: The example of Reunion Island].

Authors:
D Mété

Rev Epidemiol Sante Publique 2017 Nov 27;65(6):443-452. Epub 2017 Oct 27.

Service d'addictologie, CHU Félix-Guyon, route de Bellepierre, 97405 Saint-Denis cedex, La Réunion; Fédération régionale d'addictologie de La Réunion, CHU Félix-Guyon, route de Bellepierre, 97405 Saint-Denis cedex, La Réunion. Electronic address:

Background: France has a complex system for the taxation of alcoholic beverages. In the French overseas territories (FOT), the system includes little-known specificities whose purpose is to preserve the sugar-cane-rum sector, a pillar for the weak economies in these territories. Taxes are reduced for traditional rums produced and sold locally. Read More

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November 2017
4 Reads

Cannabis induced psychosis and subsequent psychiatric disorders.

Asian J Psychiatr 2017 Dec 16;30:180-184. Epub 2017 Oct 16.

Dept. of Psychiatry, National Institute of Mental Health And Neuro Sciences (NIMHANS), Bangalore 560029, India. Electronic address:

Introduction: Long term change in diagnosis of patients having Cannabis induced psychosis (CIP) at the index evaluation is well recognised. Some patients are known to achieve complete remission while others go on to develop independent schizophrenia or mood disorders.

Aims: To study the long-term course of CIP and factors influencing it. Read More

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December 2017
1 Read