33,515 results match your criteria Substance Use & Misuse [Journal]


Addiction, Identity, Morality.

AJOB Empir Bioeth 2019 Apr 23:1-18. Epub 2019 Apr 23.

c Uehiro Centre for Practical Ethics, University of Oxford, Oxford, United Kingdom.

Background: Recent literature on addiction and judgments about the characteristics of agents has focused on the implications of adopting a "brain disease" versus "moral weakness" model of addiction. Typically, such judgments have to do with what capacities an agent has (e.g. Read More

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http://dx.doi.org/10.1080/23294515.2019.1590480DOI Listing

Target-related parietal P3 and medial frontal theta index the genetic risk for problematic substance use.

Psychophysiology 2019 Apr 23:e13383. Epub 2019 Apr 23.

Department of Psychology, University of Minnesota, Minneapolis, Minnesota.

Theoretical and empirical work suggests that problematic substance use (PSU) is associated with individual differences in prefrontal cortex activity. While research has strongly linked parietal P3 amplitude reduction (P3AR) to genetic risk for problematic substance use, few studies have tested whether prefrontal EEG measures are sensitive to this genetic liability. In addition to P3, oddball target detection tasks elicit medial frontal theta power, reflecting attentional allocation, and parietal delta, indexing decision making or stimulus-response link updating. Read More

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http://dx.doi.org/10.1111/psyp.13383DOI Listing

NIDA Genomics Consortium White Paper: Coordinating Efforts Between Human and Animal Addiction Studies.

Genes Brain Behav 2019 Apr 23:e12577. Epub 2019 Apr 23.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA.

The National Institute on Drug Abuse Genetics and Epigenetics Cross-Cutting Research Team convened a diverse group of researchers, clinicians, and healthcare providers on the campus of the University of California, San Diego, in June 2018. The goal was to develop strategies to integrate genetics and phenotypes across species to achieve a better understanding of substance use disorders through associations between genotypes and addictive behaviors. This conference (1) discussed progress in harmonizing large opioid genetics cohorts, (2) discussed phenotypes that are used for genetics studies in humans, (3) examined phenotypes that are used for genetics studies in animal models, (4) identified synergies and gaps in phenotypic analyses of human and animal models, and (5) identified strategies to integrate genetics and genomics data with phenotypes across species. Read More

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http://dx.doi.org/10.1111/gbb.12577DOI Listing

Co-occurring substance use disorder: The impact on treatment adherence in women with locally advanced cervical cancer.

Gynecol Oncol Rep 2019 May 27;28:116-119. Epub 2019 Mar 27.

Virginia Commonwealth University Health System, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, United States of America.

The purpose of this study was to identify the prevalence of substance use disorder and its association with adherence to treatment and survival in locally advanced cervical cancer patients treated with primary radiation therapy. This is a retrospective case series of locally advanced cervical cancer patients with substance use disorder in a single academic institution treated with radiation therapy between 2005 and 2016. Substance use disorder was identified through chart review. Read More

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http://dx.doi.org/10.1016/j.gore.2019.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460223PMC

Predictors of Time to First Line Antiretroviral Treatment Failure among Adult Patients Living with HIV in Public Health Facilities of Arba Minch Town, Southern Ethiopia.

Ethiop J Health Sci 2019 Mar;29(2):175-186

Arba Minch University, College of Medicine & Health Sciences, Department of Public Health, Arba Minch, Ethiopia.

Background: Antiretroviral therapy is a proven medication given for Human Immunodeficiency Virus positive individuals. However, first-line antiretroviral treatment failure becomes a public health issue and early detection of treatment failure is crucial for timely actions. Therefore, this study aimed to identify the predictors of time to first-line antiretroviral treatment failure among adult patients living with HIV in public health facilities of Arba Minch Town. Read More

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http://dx.doi.org/10.4314/ejhs.v29i2.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460441PMC

Parental Identification and Response to Adolescent Substance Use and Substance Use Disorders.

Drugs (Abingdon Engl) 2019 9;26(2):175-183. Epub 2017 Oct 9.

Department of Psychology, Rowan University College of Humanities and Social Sciences, Glassboro, NJ, USA.

Previous research showing that parents tend to underestimate adolescent substance use is consistent with concerns that adolescent substance use may develop because parents delay in reacting to it. However, little research has examined parental decisions regarding how and when to intervene on adolescent substance use. This study examines the actions that parents report they would take after a) discovering substance use to intoxication and b) when they believe their child has a substance use problem. Read More

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http://dx.doi.org/10.1080/09687637.2017.1383973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474408PMC
October 2017

Mandatory Drug Testing of Dental Students: To Test or Not to Test: Viewpoint 1: Drug Testing of Dental Students Should Be Mandatory for the Benefit of Students, Institutions, Patients, and the Profession and Viewpoint 2: Mandatory Drug Testing of Dental Students Carries Costs and Risks for Institutions and Students and Has Unproven Benefits.

J Dent Educ 2019 Apr 22. Epub 2019 Apr 22.

Tanya Marie Gibson, DDS, is Assistant Professor, Department of Oral Pathology, Radiology, and Medicine, University of Missouri-Kansas City School of Dentistry; Maria A. Loza-Herrero, DMD, MS, is Professor, Department of Restorative Sciences, Prosthodontics Section, University of Puerto Rico School of Dental Medicine; Juan F. Yepes, DDS, MD, MPH, MS, DrPH, is Associate Professor, Department of Pediatric Dentistry, Indiana University School of Dentistry; Hera Kim-Berman, DDS, MMSc, is Clinical Assistant Professor and Program Director, Department of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry; Deborah A. Dilbone, DMD, is Clinical Associate Professor and Chair, Department of Restorative Dental Sciences, University of Florida College of Dentistry; and Herminio Perez, DMD, MBA, is Clinical Assistant Professor, Department of Restorative Dentistry, and Director of Student Affairs, Diversity, and Inclusion, Rutgers School of Dental Medicine.

An educational institution's decision to test or not test its students for drug use is controversial and complex. Although negative consequences of substance use disorder are well known, the consumption of prohibited substances continues to increase in young adults. Given the awareness of increasing drug use on college campuses and the potential impact on future health care professionals, issues associated with mandatory drug testing of dental students warrant investigation. Read More

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http://dx.doi.org/10.21815/JDE.019.086DOI Listing

Positive Youth Development Programs in Low- and Middle-Income Countries: A Conceptual Framework and Systematic Review of Efficacy.

J Adolesc Health 2019 Apr 19. Epub 2019 Apr 19.

Gender Equality Solutions, LLC, Washington, DC.

Purpose: Positive youth development (PYD) has served as a framework for youth programs in high-income countries since the 1990s and has demonstrated broad behavioral health and developmental benefits. PYD programs build skills, assets, and competencies; foster youth agency; build healthy relationships; strengthen the environment; and transform systems to prepare youth for successful adulthood. The goal of this article was to systematically review the impact of PYD programs in low- and middle-income countries (LMICs). Read More

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http://dx.doi.org/10.1016/j.jadohealth.2019.01.024DOI Listing

Safety of Psychotropic Medications During Pregnancy.

Clin Perinatol 2019 Jun 28;46(2):215-234. Epub 2019 Mar 28.

Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital Center for Women's Mental Health, Harvard Medical School, Simches Research Building, 185 Cambridge Street, Suite 2200, Boston, MA 02114, USA.

Risks, benefits, alternatives, and appropriateness of psychotropic medications, including risks of no treatment, are discussed for antidepressants, mood-stabilizing medications, anxiolytic/sedative hypnotic medications, stimulants, and medication-assisted treatment of substance use disorders. Early screening, diagnosis, and intervention prior to and/or during pregnancy often reduce morbidity and mortality of mental health disorders for mothers and infants. Read More

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http://dx.doi.org/10.1016/j.clp.2019.02.004DOI Listing

Does trauma-focused exposure therapy exacerbate symptoms among patients with comorbid PTSD and substance use disorders?

Behav Cogn Psychother 2019 Apr 23:1-16. Epub 2019 Apr 23.

Department of Psychiatry & Behavioral Sciences,Medical University of South Carolina,Charleston, SC,USA.

Background: Although exposure-based therapy is a well-established, effective treatment for post-traumatic stress disorder (PTSD), some practitioners report reluctance to implement it due to concerns that it may exacerbate symptoms of PTSD and commonly comorbid disorders, such as substance use disorders (SUD).

Aim: This study compared the exacerbation of psychological symptoms among participants with comorbid PTSD and SUD who received either SUD treatment alone or SUD treatment integrated with exposure therapy for PTSD.

Method: Participants (N = 71) were treatment-seeking, military Veterans with comorbid PTSD and SUD who were randomized to 12 individual sessions of either (1) an integrated, exposure-based treatment (Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure; COPE); or (2) a non-exposure-based, SUD-only treatment (Relapse Prevention; RP). Read More

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http://dx.doi.org/10.1017/S1352465819000304DOI Listing

Delivering LGBT-sensitive substance use treatment to sexual minority women.

J Gay Lesbian Soc Serv 2018 18;30(4):393-408. Epub 2019 Jan 18.

Alcohol Research Group at the Public Health Institute, Emeryville, CA.

Epidemiologic studies have consistently found elevated rates of alcohol and other substance use among sexual minority women (SMW), and despite calls for "LGBT-specific" services and culturally-tailored interventions, few such services exist. This study involved qualitative interviews with directors from substance use treatment programs (N=10) about how they addressed the needs of SMW. Strategies implemented primarily focused on creating a safe and welcoming environment for sexual minority clients. Read More

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http://dx.doi.org/10.1080/10538720.2018.1512435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469851PMC
January 2019

The treatment gap for mental disorders and associated factors in the Czech Republic.

Eur Psychiatry 2019 Apr 19;59:37-43. Epub 2019 Apr 19.

National Institute of Mental Health, Klecany, Czech Republic; Third Faculty of Medicine, Charles University Prague, Czech Republic. Electronic address:

Objectives: To assess the extent of the treatment gap for mental disorders in the Czech Republic, determine factors associated with the utilization of mental health services and explore what influences willingness to seek mental health care.

Methods: Data from the CZEch Mental health Study, a nationally representative study of community-dwelling adults in the Czech Republic were used. The Mini International Neuropsychiatric Interview assessed the presence of mental disorders. Read More

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http://dx.doi.org/10.1016/j.eurpsy.2019.04.003DOI Listing

Veterans with PTSD and comorbid substance use disorders: Does single versus poly-substance use disorder affect treatment outcomes?

Drug Alcohol Depend 2019 Apr 9;199:70-75. Epub 2019 Apr 9.

Department of Behavioral Sciences and Psychiatry, Division of Addiction Sciences, Medical University of South Carolina, 5 Charleston Center Dr., Suite 151, Charleston, SC, 29401 USA; Ralph H. Johnson VA Medical Center, 109 Bee St., Charleston, SC, 29401 USA.

Introduction: Substance use disorders (SUD) frequently co-occur with posttraumatic stress disorder (PTSD). Little is known, however, about how individuals with a single SUD diagnosis (relating to only one substance) compare to individuals with poly-SUD diagnoses (relating to more than one substance) on substance use and PTSD treatment outcomes. To address this gap in the literature, we utilized data from a larger study investigating a 12-week integrated, exposure-based treatment (i. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2019.04.001DOI Listing

Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine.

Neuropharmacology 2019 Apr 19. Epub 2019 Apr 19.

Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, 21224, USA. Electronic address:

Substance use disorders (SUD) are serious public health problems worldwide. Although significant progress has been made in understanding the neurobiology of drug reward and the transition to addiction, effective pharmacotherapies for SUD remain limited and a majority of drug users relapse even after a period of treatment. The United States Food and Drug Administration (FDA) has approved several medications for opioid, nicotine, and alcohol use disorders, whereas none are approved for the treatment of cocaine or other psychostimulant use disorders. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.015DOI Listing
April 2019
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Pharmacological Treatment of Youth Substance Use Disorders.

J Child Adolesc Psychopharmacol 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina.

While the majority of youth who experiment with alcohol and drugs do not develop problematic levels of use, 5% of adolescents and 15% of young adults meet criteria for a substance use disorder (SUD). Pharmacotherapy, in combination with behavioral interventions, has the potential to increase the likelihood of successful treatment for youth struggling with SUD; however, the literature in this area is limited. To date, there are no Food and Drug Administration (FDA)-approved medications for adolescent SUD, other than buprenorphine, which has been approved down to 16 years of age for opioid use disorder. Read More

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http://dx.doi.org/10.1089/cap.2019.0009DOI Listing

Multivariate analyses reveal biological components related to neuronal signaling and immunity mediating EEG abnormalities in alcohol-dependent individuals from the COGA cohort.

Alcohol Clin Exp Res 2019 Apr 22. Epub 2019 Apr 22.

Olin Neuropsychiatry Research Center, Hartford Hospital/IOL, Hartford, CT, 06107.

Background: The underlying molecular mechanisms associated with alcohol use disorder (AUD) risk have only been partially revealed using traditional approaches such as univariate GWAS and linkage-based analyses. We therefore aimed to identify gene clusters related to EEG neurobiological phenotypes distinctive to individuals with AUD using a multivariate approach.

Methods: The current project adopted a bi-multivariate data-driven approach, parallel independent component analysis (para-ICA) to derive and explore significant genotype-phenotype associations in a case-control subset of the Collaborative Study on the Genetics of Alcoholism (COGA) dataset. Read More

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http://dx.doi.org/10.1111/acer.14063DOI Listing

Altered neuropsychological performance and reduced brain volumetrics in people living with HIV on integrase strand transfer inhibitors.

AIDS 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, Washington University in St Louis, St Louis, USA.

Objectives: Neuropsychiatric symptoms have been reported in people living with HIV (PLWH) on integrase strand transfer inhibitors (INSTIs) in post marketing analysis. Limited data exists regarding brain integrity (function and structure) in PLWH prescribed INSTIs compared to other HIV treatment regimens.

Design: A cross-sectional analysis of PLWH on combined antiretroviral therapy (cART) aged >18 years at a single institution. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002236DOI Listing
April 2019
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Diagnosis and treatment of patients with comorbid substance use disorder and adult attention-deficit and hyperactivity disorder: a review of recent publications.

Curr Opin Psychiatry 2019 Apr 16. Epub 2019 Apr 16.

Amsterdam Institute of Addiction Research (AIAR), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Purpose Of Review: Attention-deficit and hyperactivity disorder (ADHD) often presents with comorbid substance use disorders (SUD). Due to similarities in key symptoms of both disorders and suboptimal efficacy of the available treatments, clinicians are faced with difficulties in the diagnosis and treatment of these patients with both disorders. This review addresses recent publications between 2017 and 2019 on the etiology, prevalence, diagnosis and treatment of co-occurring ADHD and SUD. Read More

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http://dx.doi.org/10.1097/YCO.0000000000000513DOI Listing

Smartphone Apps Targeting Alcohol and Illicit Substance Use: Systematic Search in in Commercial App Stores and Critical Content Analysis.

JMIR Mhealth Uhealth 2019 Apr 22;7(4):e11831. Epub 2019 Apr 22.

Department of Population Health, New York University School of Medicine, New York, NY, United States.

Background: Smartphone apps promise to enhance the reach of evidence-based interventions (cognitive behavior therapy, contingency management and therapeutic education system) for populations with substance use disorders, with minimal disruption to health systems. However, further studies are needed to systematically evaluate smartphone apps targeting alcohol and illicit substances.

Objective: The aim of this study was to evaluate the functionality, aesthetics, and quality of information of free or low-cost apps claiming to target alcohol, benzodiazepine, cocaine, crack/cocaine, crystal methamphetamine, and heroin use using the validated Mobile App Rating Scale (MARS) and critical content analysis. Read More

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http://dx.doi.org/10.2196/11831DOI Listing
April 2019
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Demystifying buprenorphine misuse: Has fear of diversion gotten in the way of addressing the opioid crisis?

Subst Abus 2019 Apr 22:1-6. Epub 2019 Apr 22.

b Johns Hopkins Bloomberg School of Public Health , Baltimore , Maryland , USA.

Buprenorphine is considered one of the most effective treatments for opioid use disorder and significantly reduces risk of overdose death. However, concerns about its diversion and misuse have often taken center stage in public discourse and in the design of practices and policies regarding its use. This has been to the detriment of many vulnerable patient populations, especially those involved in the criminal justice system. Read More

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http://dx.doi.org/10.1080/08897077.2019.1572052DOI Listing
April 2019
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The prevalence of substance use in child welfare and general population eighth graders in the United States.

Authors:
Julia M Kobulsky

Subst Use Misuse 2019 Apr 22:1-9. Epub 2019 Apr 22.

a School of Social Work College of Public Health , Temple University , Philadelphia , Pennsylvania , USA.

Background: Early substance use is an established risk factor for substance abuse and dependence.

Objective: The current study sought to examine whether child welfare-involved eighth graders have higher rates of early substance use than general population eighth graders. Data from the first National Survey of Child and Adolescent Well-Being (NSCAW) were analyzed to assess the prevalence of self-reported substance use, including alcohol, marijuana, and inhalant use in child welfare-involved eighth graders (N = 896). Read More

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https://www.tandfonline.com/doi/full/10.1080/10826084.2019.1
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http://dx.doi.org/10.1080/10826084.2019.1594907DOI Listing
April 2019
1 Read

Evidence of fentanyl use is common and frequently missed in a cross-sectional study of emergency department patients in Baltimore, Maryland.

Clin Toxicol (Phila) 2019 Apr 22:1-3. Epub 2019 Apr 22.

b Center for Substance Abuse Research (CESAR) , University of Maryland , College Park , MD , USA.

Objective: Fentanyl-associated deaths have risen in Maryland, but the prevalence of illicit fentanyl use is unknown. Our objective was to measure whether fentanyl is present among emergency department (ED) patients seeking care for a drug overdose.

Design: The prevalence of fentanyl use was determined using a cross-sectional study of a convenience sample of adult ED patients with complaints of apparent opioid overdose, withdrawal from opioids, and/or requesting treatment for their substance use disorder (SUD) between February and April, 2018. Read More

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http://dx.doi.org/10.1080/15563650.2019.1605078DOI Listing
April 2019
1 Read

Distress tolerance trajectories following substance use treatment.

J Consult Clin Psychol 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill.

Objective: Distress tolerance (DT), the ability to withstand aversive internal states, represents an important risk factor for substance use relapse and a potential treatment target. Neurobiological research in substance using populations suggests that continued substance use could erode DT, whereas abstinence could bolster it. The current study characterized trajectories of behavioral and self-reported indices of DT and examined the prospective effect of substance use on DT trajectories among those seeking treatment for substance use. Read More

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http://dx.doi.org/10.1037/ccp0000403DOI Listing

Trends in substance use and in the attributable burden of disease and mortality in the WHO European Region, 2010-16.

Eur J Public Health 2019 Apr 22. Epub 2019 Apr 22.

WHO European Office for Prevention and Control of Noncommunicable Diseases, World Health Organization, Regional Office for Europe, Moscow, Russian Federation.

Background: This paper examines changes in substance use, and compares the resulting attributable burden of disease in the WHO European Region between 2010 and 2016.

Methods: Data for 2010 and 2016 on the number of deaths, years of life lost (YLL) and disability-adjusted life years (DALYs) lost were obtained by sex and country from the 2016 Global Burden of Disease (GBD) study. Exposure data for all substances except alcohol were obtained from the same study, while alcohol data were obtained from the WHO. Read More

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http://dx.doi.org/10.1093/eurpub/ckz064DOI Listing

Youth consumption of alcohol mixed with energy drinks in Canada: Assessing the role of energy drinks.

Prev Med Rep 2019 Jun 5;14:100865. Epub 2019 Apr 5.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Canada.

Consuming alcohol mixed with energy drinks (AmED) is a risk behaviour among youth, and previous research has reported a positive association between binge drinking and AmED consumption. However, limited research has examined how regular consumption of energy drinks is associated with AmED consumption among youth. The purpose of this report is to examine the role of energy drink use on AmED consumption in a Canadian youth population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22113355193005
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http://dx.doi.org/10.1016/j.pmedr.2019.100865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458478PMC
June 2019
1 Read

Associations between parenting and substance use, meal pattern and food choices: A cross-sectional survey of 13,269 Norwegian adolescents.

Prev Med Rep 2019 Jun 30;14:100862. Epub 2019 Mar 30.

Faculty of Health and Sport Sciences, Department of Public Health, Sport and Nutrition, University of Agder, Postbox 422, 4604 Kristiansand, Norway.

Identifying factors that affect adolescent lifestyle behaviors is essential in order to develop effective generic prevention approaches. This study aimed to investigate the association between parental monitoring, parental emotional support, parental-adolescent conflict and adolescent substance use, meal pattern and food choices. The study included data from 13,269 Norwegian adolescents aged 13-16 years collected in 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22113355193004
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http://dx.doi.org/10.1016/j.pmedr.2019.100862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458480PMC
June 2019
1 Read

Repetitive transcranial magnetic stimulation (rTMS) using different TMS instruments for major depressive disorder at a suburban tertiary clinic.

Ment Illn 2019 Mar 22;11(1):7947. Epub 2019 Mar 22.

Department of Psychiatry and Behavioral Sciences, University of Kansas Medical Center, KS, USA.

Repetitive transcranial magnetic stimulation (rTMS) is a neurostimulatory technique used to modulate orbital frontal corticostriatal (OFC) activity and clinical symptomatology for psychiatric disorders involving OFC dysfunction. We examined the effectiveness of rTMS in the treatment of major depressive disorder in an applied clinical setting (Awakening KC CNI) to assess efficacy and optimize rTMS parameters within clinical practice. A retrospective review of medical records was carried out on patients with major depressive disorder undergoing rTMS therapy at Awakenings KC Clinical Neuroscience Institute (CNI), a suburban tertiary psychiatric clinic. Read More

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http://dx.doi.org/10.4081/mi.2019.7947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452224PMC

Mental Health and Substance Use Disorders in Patients Diagnosed With Cancer: An Integrative Review of Healthcare Utilization.

Oncol Nurs Forum 2019 May;46(3):365-383

University of Connecticut.

Problem Identification: The impact of mental health disorders (MHDs) and substance use disorders (SUDs) on healthcare utilization (HCU) in patients with cancer is an understudied phenomenon.

Literature Search: A literature search of studies published prior to January 2018 that examined HCU in patients with preexisting MHDs or SUDs diagnosed with cancer was conducted.

Data Evaluation: The research team evaluated 22 studies for scientific rigor and examined significant trends in HCU, as well as types of the MHD, SUD, and cancer studied. Read More

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http://dx.doi.org/10.1188/19.ONF.365-383DOI Listing

The Relationships Among Social Capital, HIV Self-Management, and Substance Use in Women.

West J Nurs Res 2019 Apr 21:193945919842874. Epub 2019 Apr 21.

4 University of California, San Francisco, USA.

Women living with HIV (WLHIV) face unique challenges to successfully self-manage HIV including substance use and limited social capital. We conducted a 6-month mixed-methods study to describe how social capital influences HIV self-management and substance use among WLHIV. Participants completed a self-report survey and in-depth interview at baseline, and 3 and 6 months. Read More

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http://dx.doi.org/10.1177/0193945919842874DOI Listing

Psychological wellbeing and use of alcohol and recreational drugs: results of the British HIV Association (BHIVA) national audit 2017.

HIV Med 2019 Apr 22. Epub 2019 Apr 22.

The James Cook University Hospital, Middlesbrough, UK.

Objectives: The aim of this national audit was to assess adherence of services providing HIV care in the UK to national standards and guidelines regarding psychological support and the assessment of alcohol and recreational drug use (including chemsex drugs) in people living with HIV (PLWH).

Methods: Participating sites completed a survey of their services' care pathways relating to psychological support and substance use. They performed a case-note review of up to 40 adult PLWH per service, reviewing sociodemographic and clinical information and assessment of psychological wellbeing, drug use and alcohol use. Read More

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http://dx.doi.org/10.1111/hiv.12744DOI Listing

The role of cancer in marijuana and prescription opioid use in the United States: A population-based analysis from 2005 to 2014.

Cancer 2019 Apr 22. Epub 2019 Apr 22.

Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California.

Background: For patients with cancer, marijuana may be an alternative to prescription opioid analgesics. This study analyzed self-reported marijuana and prescription opioid use among people with cancer over a 10-year time period.

Methods: Population-based data sets from the US National Health and Nutrition Examination Survey between 2005 and 2014 were compiled for respondents aged 20 to 60 years. Read More

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http://dx.doi.org/10.1002/cncr.32059DOI Listing

Telemedicine-delivered treatment interventions for substance use disorders: A systematic review.

J Subst Abuse Treat 2019 Mar 21;101:38-49. Epub 2019 Mar 21.

University of California, San Diego, School of Medicine, Department of Family Medicine and Public Health, 9500 Gilman Drive #0725, La Jolla, CA 92093-0725, United States of America.

With increased negative impacts from opioid and other substance use disorders in the US, it is important for treatments to not only be effective, but also accessible to patients. Treatment delivery via telemedicine, specifically, the use of videoconferencing, which allows real time communication between a patient and a clinician at a distant site, has been shown to be an effective approach for increasing reach and access to treatments for mental health disorders and other chronic illnesses. This systematic review identified and summarized studies examining the effectiveness of telemedicine interventions to deliver treatment for patients with substance use disorders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07405472183042
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http://dx.doi.org/10.1016/j.jsat.2019.03.007DOI Listing
March 2019
1 Read

[Day hospitalisation in addictology].

Soins Psychiatr 2019 Mar - Apr;40(321):41-44

Unité d'addictologie-consultation mémoire, hôpital des Chanaux, 71018 Mâcon cedex, France.

The day hospital in addictology is a recent hospital service for patients with substance use disorders. It lies somewhere between an inpatient withdrawal unit and outpatient consultations. The day hospital service provides care ranging from withdrawal preparation, abstinence support, the reduction of risks or harm and long-term support for patients. Read More

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http://dx.doi.org/10.1016/j.spsy.2019.01.007DOI Listing

Pragmatic neuroscience for clinical psychiatry.

Br J Psychiatry 2019 Apr 22:1-5. Epub 2019 Apr 22.

Laureate Institute for Brain Research,University of Tulsa,USA.

SummaryMental health and substance use disorders are the leading cause of long-term disability and a cause of significant mortality, worldwide. However, it is widely recognised that clinical practice in psychiatry has not fundamentally changed for over half a century. The Royal College of Psychiatrists is reviewing its trainee curriculum to identify neuroscience that relates to psychiatric practice. Read More

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https://www.cambridge.org/core/product/identifier/S000712501
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http://dx.doi.org/10.1192/bjp.2019.88DOI Listing
April 2019
5 Reads

Temperament and character influence on depression treatment outcome.

J Affect Disord 2019 Apr 9;252:464-474. Epub 2019 Apr 9.

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Italy. Electronic address:

Background: personality features have been repeatedly associated with depression treatment outcome in Major Depressive Disorder (MDD), however conclusive results are still lacking. Moreover, as for Bipolar Disorder (BD), results are only few and preliminary.

Aim: the aim of the present study was to perform an exploratory investigation of the influence of personality traits as assessed by the Temperament and Character Inventory (TCI), on principal depression treatment outcomes (non remission, non response and resistance). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183178
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http://dx.doi.org/10.1016/j.jad.2019.04.031DOI Listing
April 2019
1 Read

Microglial alterations induced by psychoactive drugs: A possible mechanism in substance use disorder?

Semin Cell Dev Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dynamic and Clinical Psychology, University of Rome "La Sapienza," Via degli Apuli 1, 00185, Rome, Italy; IRCCS Santa Lucia Foundation, Via Fosso di Fiorano 64, 00143, Rome, Italy. Electronic address:

Recently, the xenobiotic hypothesis has implicated the immune system in targeting substances of abuse as foreign molecules and stimulating inflammatory responses. Microglial cells are the resident immune cells of the central nervous system and function in homeostatic surveillance. Microglial changes that are induced by exposure to substances of abuse appear to mediate in part the establishment of addiction and the persistence of drug-mediated biological and behavioral changes. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.03.008DOI Listing
April 2019
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Mental health and substance use disorders: The reality of youth in custody.

Int J Ment Health Nurs 2019 Jun;28(3):633-634

Faculty of Health, University of Technology, Sydney (UTS), Ultimo, New South Wales, Australia.

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http://dx.doi.org/10.1111/inm.12597DOI Listing

The validity of conduct disorder symptom profiles in high-risk male youth.

Eur Child Adolesc Psychiatry 2019 Apr 19. Epub 2019 Apr 19.

Department of Child and Adolescent Psychiatry, Paracelsus Medical University, Salzburg, Austria.

Conduct disorder (CD) is a heterogeneous pattern of rule-breaking and aggressive symptoms. Until now it has been unclear whether valid, clinically useful symptom profiles can be defined for populations in youth at high-risk of CD. Interview-based psychiatric disorders, CD symptoms and officially recorded offences were assessed in boys from a detention facility and a forensic psychiatric hospital (N = 281; age 11. Read More

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http://link.springer.com/10.1007/s00787-019-01339-z
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http://dx.doi.org/10.1007/s00787-019-01339-zDOI Listing
April 2019
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Cannabis abuse and dependence in kidney transplant candidates.

J Psychosom Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA. Electronic address:

Objective: Cannabis is the most commonly used non-alcohol intoxicant in the general population. There are no consistent guidelines on the implications of cannabis abuse and dependence (CAD) in kidney transplant candidates. The aims of this study were to characterize kidney transplant candidates with comorbid CAD and examine the implications of CAD on transplant candidacy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223999183101
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http://dx.doi.org/10.1016/j.jpsychores.2019.04.004DOI Listing
April 2019
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U.S. National 90-Day Readmissions After Opioid Overdose Discharge.

Am J Prev Med 2019 Apr 16. Epub 2019 Apr 16.

National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia.

Introduction: U.S. hospital discharges for opioid overdose increased substantially during the past two decades. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.12.003DOI Listing

Acceptability of mindfulness-based interventions for substance use disorder: A systematic review.

Complement Ther Clin Pract 2019 May 20;35:201-207. Epub 2019 Feb 20.

Florida International University, Wertheim College of Medicine and Stempel College of Public Health and Social Work, USA.

Background: and Purpose: Mindfulness-based interventions (MBI) for substance use disorders (SUD) have shown promising results. However, acceptability of MBIs in the context of SUD treatment has yet to be systematically assessed across published studies. Our aims were to (a) review the literature for assessments of acceptability; (b) summarize how, when, and for whom acceptability is being measured; and (c) create suggestions for best practices in measuring acceptability of MBIs for SUD. Read More

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http://dx.doi.org/10.1016/j.ctcp.2019.02.012DOI Listing

Psychiatric Disorders and Alcohol Consumption Among Low-Income African Americans:Gender Differences.

Brain Sci 2019 Apr 18;9(4). Epub 2019 Apr 18.

Department of Family Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.

Background: Although cooccurrence of nonsubstance use disorders (non-SUDs) and substance use is well-established in the literature, most of what we know in this regard is derived from studies that have recruited predominantly White sample populations. As a result, there is a gap in knowledge on this link among low-income African Americans (AAs). There is also a need to understand how low-income AA men and women differ in these associations. Read More

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http://dx.doi.org/10.3390/brainsci9040086DOI Listing

Computerized intervention to prevent drug use among at-risk adolescents in Central Asia: Preliminary family-level findings from a pilot mixed methods trial.

Int J Drug Policy 2019 Apr 16;68:75-85. Epub 2019 Apr 16.

Global Health Research Center of Central Asia (GHRCCA), Almaty, Kazakhstan.

Background: The rapidly growing rates of HIV infection in Kazakhstan are largely driven by injection drug use. The study adapts a family-focused evidence-based HIV and substance use prevention intervention for at-risk adolescents from communities in Almaty that have been greatly affected by heroin trade and use.

Methods: This NIDA-funded pilot feasibility trial included 181 at-risk adolescents (ages 14-17) recruited through local schools and 181 of their parents or other adult family members. Read More

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http://dx.doi.org/10.1016/j.drugpo.2019.03.022DOI Listing

The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task.

Brain Res 2019 Apr 16. Epub 2019 Apr 16.

Brain Health Institute, Rutgers University, Piscataway, NJ, USA.

There is considerable clinical interest in the neuropeptide orexin/hypocretin for its ability to regulate motivation and reward as well as arousal and wakefulness. For instance, antagonists for the orexin-1 receptor (OxR1) are thought to hold great promise for treating drug addiction and disorders associated with overeating, as these compounds repeatedly have been found to suppress seeking of various drugs of abuse as well as highly palatable foods in preclinical models. Given the hypothesized role of OxR1 signaling in cue-driven motivation, an outstanding question is whether pharmacologically blocking this receptor affects cognitive functioning. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.017DOI Listing

Pathways Into Homelessness Among LGBTQ2S Adults.

J Homosex 2019 Apr 19:1-19. Epub 2019 Apr 19.

b Centre for Research on Educational and Community Services and School of Psychology , University of Ottawa , Ottawa , Ontario , Canada.

This article examines entries into homelessness among adults who identify as LGBTQ2S (lesbian, gay, bisexual, transgender, queer, two-spirit). Twenty LGBTQ2S adults who were currently or formerly homeless participated in one qualitative interview. The interview protocol included questions on the participants' history of homelessness, causes of homelessness, and relationship of their gender and/or sexual identity to their homelessness. Read More

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https://www.tandfonline.com/doi/full/10.1080/00918369.2019.1
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http://dx.doi.org/10.1080/00918369.2019.1600902DOI Listing
April 2019
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Is the Sum Greater than its Parts? Variations in Substance-Related Consequences by Conjoint Alcohol-Marijuana Use Patterns.

J Psychoactive Drugs 2019 Apr 19:1-9. Epub 2019 Apr 19.

b Department of Psychology , Palo Alto University , Palo Alto , CA , USA.

Alcohol and marijuana are the most commonly used substances for college-attending young adults. This study evaluated differences in substance-specific consequence attribution by alcohol-marijuana use patterns (concurrent alcohol and marijuana [CAM; use of both substances, not at same time] and simultaneous [SAM; use of both, at same time]) as well as alcohol-only (AO). First-year college students with prior alcohol use (N = 610, 50. Read More

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http://dx.doi.org/10.1080/02791072.2019.1599473DOI Listing

Substance use in kidney transplant candidates and its impact on access to kidney transplantation.

Clin Transplant 2019 Apr 19:e13565. Epub 2019 Apr 19.

Division of Nephrology, Multi-Organ Transplant Program, University Health Network and University of Toronto, Toronto, Canada.

Background: Due to the increasing public acceptance of substance use, it is important to understand the association between substance use and access to kidney transplant and its outcomes. Here we assess the sociodemographic predictors of substance use and the association between substance use and KT access.

Methods: Predictors of substance use were examined using a multivariable-adjusted multinomial logistic regression. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ctr.13565
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http://dx.doi.org/10.1111/ctr.13565DOI Listing
April 2019
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Adult Mental Health Outpatients Who Have Minor Children: Prevalence of Parents, Referrals of Their Children, and Patient Characteristics.

Front Psychiatry 2019 2;10:163. Epub 2019 Apr 2.

Health Services Research, SINTEF, Trondheim, Norway.

A strong connection exists between parental mental illness and lifetime mental health risk for their children. Thus, it is important to determine, when parents attend for treatment for their illness, the prevalence and characteristics of parents with a mental illness and identify referral actions for their children. Previous studies indicate that 12-45% of adult mental health service patients are parents with minor children. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456127PMC

Substance Use Disorder in People with Intellectual Disabilities: Current Challenges in Low- and Middle-Income Countries.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):301-305

Behavioral and Environment Health, Jackson State University, Jackson, Mississippi, USA.

Use of illegal and prescription drugs has significantly increased in recent years all over the world in most populations. Greater worldwide awareness in this regard has substantially improved the epidemiological understanding of substance use, its risk factors, and impact on life. People with intellectual disabilities constitute 0. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/301/254
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http://dx.doi.org/10.4103/jnrp.jnrp_393_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454939PMC
April 2019
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Post traumatic stress disorder and coping strategies among adult survivors of earthquake, Nepal.

BMC Psychiatry 2019 Apr 18;19(1):118. Epub 2019 Apr 18.

Gandaki Medical College Teaching Hospital and Research Centre, Tribhuvan University, Pokhara, Nepal.

Background: Post traumatic stress disorder (PTSD) is the most frequently reported psychiatric morbidity among the survivors of natural disasters. It is the main hindrance to rehabilitate their life. However its prevalence particularly in Nepal is largely unknown. Read More

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https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12888-019-2090-yDOI Listing
April 2019
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