286 results match your criteria Subcutaneous Fat Necrosis of the Newborn


Subcutaneous Fat Necrosis and Hypercalcemia with Nephrocalcinosis in Infancy: Case Report and Review of the Literature.

Children (Basel) 2021 May 9;8(5). Epub 2021 May 9.

1st Department of Pediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital Thessaloniki, 54642 Thessaloniki, Greece.

Subcutaneous fat necrosis is an uncommon benign panniculitis affecting more commonly full-term newborns. It has been associated with birth asphyxia and meconium aspiration, as well as therapeutic hypothermia. Although the prognosis is generally favorable, complications such as hypercalcemia, thrombocytopenia, hypoglycemia and hypertriglyceridemia may complicate its course. Read More

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Subcutaneous fat necrosis of the newborn - An atypical case with typical complications.

Clin Case Rep 2021 Apr 18;9(4):2069-2073. Epub 2021 Feb 18.

Department of Pediatrics Hospital Garcia de Orta, EPE Lisbon Portugal.

Subcutaneous fat necrosis of the newborn should be considered in newborns with suggestive skin lesions, even in the absence of perinatal distress. SCFN may cause long-standing complications, like hypertriglyceridemia or hypercalcemia. Hypercalcemia can be refractory to therapy and lead to poor weight gain and nephrocalcinosis, which should be closely monitored. Read More

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Clinicopathological features of neonatal subcutaneous fat necrosis and implications.

Endokrynol Pol 2021 Mar 22. Epub 2021 Mar 22.

Department of Neonatology. Centro Hospitalar São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, 4200 Porto, Portugal.

Not required for Clinical Vignette. Read More

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Severe hypercalcemia and acute renal failure in an infant with subcutaneous fat necrosis.

Paediatr Int Child Health 2021 Mar 14:1-5. Epub 2021 Mar 14.

Divisions of Nephrology and Endocrinology, Department of Paediatrics, Pamukkale University Faculty of Medicine, Denizli, Turkey.

Subcutaneous fat necrosis (SFN) in the newborn is a form of panniculitis which presents with erythematous nodules and indurated plaques. Severe life-threatening hypercalcaemia can occur as a late complication. A 2-month-old girl presented with severe hypercalcaemia and acute renal injury as a complication of SFN. Read More

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A Case Report and Anesthetic Considerations in Subcutaneous Fat Necrosis of the Newborn.

Authors:
Marla M Matar

A A Pract 2021 Mar 8;15(3):e01422. Epub 2021 Mar 8.

From the Department of Pediatrics and Anesthesiology, University of Southern California.

Subcutaneous fat necrosis of the newborn (SCFN) is an uncommon, self-limiting panniculitis generally diagnosed in the first few weeks of extrauterine life in term or postterm infants subjected to perinatal physiologic stress. Hallmarks of the process include dramatic hypercalcemia without identifiable cause that may be associated with renal disease, seizures, and death. Herein, we describe the anesthetic approach in an 11-week-old infant, including perioperative laboratory testing, management of hypercalcemia, and intraoperative considerations. Read More

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Subcutaneous fat necrosis of the newborn: clinical and histopathological review and use of cutaneous ultrasound Necrosis grasa subcutánea del recién nacido: revisión clínica e histopatológica y utilidad de la ecografía cutánea.

Dermatol Online J 2020 Nov 15;26(11). Epub 2020 Nov 15.

Servicio de Dermatología, Hospital Clínico Universitario, Valencia.

Subcutaneous fat necrosis of the newborn is a rare lobular panniculitis. It is characteristic of term or post-term neonates with a history of perinatal compromise or maternal gestational pathology. The cutaneous manifestations consist of erythematous and indurated subcutaneous plaques and nodules located over the dorsal region and the shoulders. Read More

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November 2020

Neutrophilic Infiltrates in Panniculitis: Comprehensive Review and Diagnostic Algorithm Proposal.

Am J Dermatopathol 2020 Oct;42(10):717-730

Dermatologist and Dermatopathologist, Kempf und Pfaltz Histologische Diagnostic, Zürich, Switzerland.

Neutrophilic infiltrates in panniculitis can be seen in different clinical-pathological entities. There are a "mostly neutrophilic inflammatory infiltrate" in some entities classically defined as neutrophilic panniculitis and already included in algorithms, such as enzymatic panniculitis, infective and factitial ones, erythema induratum, or subcutaneous Sweet syndrome, but there are also other panniculitis where neutrophils are frequently observed such as panniculitis associated with inflammatory bowel disease or rheumatoid arthritis, or drug-induced panniculitis associated with BRAF inhibitors, and finally, some panniculitis are better classified in other panniculitides groups but may present with neutrophil-rich variants, such as the neutrophil-rich subcutaneous fat necrosis of the newborn. We review the main clinical and histopathological features of most of these panniculitides and construct a diagnostic algorithm including these diseases. Read More

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October 2020

Lessons learnt in the management of hypercalcaemia secondary to subcutaneous fat necrosis of the newborn.

J Paediatr Child Health 2021 06 11;57(6):947-949. Epub 2020 Aug 11.

Department of Endocrinology and Diabetes, Queensland Children's Hospital, Brisbane, Queensland, Australia.

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Fat necrosis of the newborn.

Rev Chil Pediatr 2020 Feb 3;91(1):94-98. Epub 2019 Dec 3.

Facultad de Ciencias Médicas, Universidad de Talca, Chile.

Introduction: Panniculitis is a group of diseases that affect subcutaneous fat tissue and clinically manifest as nodules. Its pathogenesis is not entirely clear, and it is usually asymptomatic. The confirma tory diagnosis is histological. Read More

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February 2020

Subcutaneous Fat Necrosis of the Newborn.

Indian Dermatol Online J 2020 May-Jun;11(3):471-472. Epub 2020 May 10.

Department of Pathology, Lal Pathology Laboratory, New Delhi, India.

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Subcutaneous fat necrosis and severe hypercalcemia as a complication of therapeutic hypothermia in a newborn with asphyxia.

Dermatol Ther 2020 11 19;33(6):e13952. Epub 2020 Jul 19.

Faculty of Medicine, Department of Dermatology, Pamukkale University, Denizli, Turkey.

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November 2020

Haematoma complicating subcutaneous fat necrosis of the newborn: a rare complication following therapeutic hypothermia.

BMJ Case Rep 2020 Jun 11;13(6). Epub 2020 Jun 11.

Pediatrics-Neonatology, University of Calgary, Calgary, Alberta, Canada.

A term, large for gestational age male newborn, was admitted to the neonatal intensive care unit with meconium aspiration syndrome and severe hypoxic-ischaemic encephalopathy. The baby was treated with therapeutic hypothermia using a total body cooling blanket. After 48 hours, the baby developed tender, indurated subcutaneous nodules consistent with subcutaneous fat necrosis (SCFN). Read More

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Severe Thrombocytosis in a Newborn with Subcutaneous Fat Necrosis and Maternal Chorioamnionitis.

Case Rep Hematol 2020 21;2020:5742394. Epub 2020 Feb 21.

Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA.

Background: Subcutaneous fat necrosis (SFN) is a form of transient panniculitis that presents commonly in infants with a history of perinatal insult, particularly hypothermia. It is characterized by subcutaneous nodules and plaques that appear over bony prominences on cheeks, shoulders, buttock, and thighs. SFN is usually associated with various complications including hypercalcemia, thrombocytopenia, hypertriglyceridemia, and hyperglycemia. Read More

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February 2020

Erythematous indurated plaques in a newborn.

Pediatr Dermatol 2020 Jan;37(1):e12-e14

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

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January 2020

Subcutaneous fat necrosis of the newborn.

BMJ Case Rep 2019 Dec 15;12(12). Epub 2019 Dec 15.

Neonatology, Rotunda Hospital, Dublin, Ireland.

A term infant developed subcutaneous fat necrosis of the newborn (SFNN) 17 days following completion of therapeutic hypothermia for hypoxic ischaemic encephalopathy. Initial calcium was normal, however hypercalcaemia requiring hyperhydration and furosemide developed at 4 weeks. Parathyroid hormone and vitamin D were suppressed. Read More

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December 2019

Report of 2 Novel Presentations of Subcutaneous Fat Necrosis of the Newborn.

Dermatopathology (Basel) 2019 Apr-Jun;6(2):147-152. Epub 2019 Jun 26.

Department of Radiology, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, Massachusetts, USA.

Subcutaneous fat necrosis of the newborn (SCFNN) is a rare form of panniculitis classically affecting healthy full-term infants. There are a number of predisposing factors including perinatal asphyxia. The condition generally has a benign course with spontaneous resolution, but monitoring for metabolic complications, in particular the potentially life-threatening complication of hypercalcaemia, is critical. Read More

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Subcutaneous fat necrosis, a rare but serious side effect of hypoxic-ischemic encephalopathy and whole-body hypothermia.

J Perinat Med 2019 Nov;47(9):986-990

Neonatal-Perinatal Medicine, The State University of New York, University at Buffalo, Buffalo, NY, USA.

Objective To describe the clinical characteristics and risk factors in infants with subcutaneous fat necrosis (SFN) following therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE). Methods A case-control study was performed by a retrospective chart review of infants with moderate or severe HIE admitted to a level IV regional perinatal center and who underwent whole-body cooling. Results A total of 14 (8. Read More

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November 2019

A Case Study of Severe Hypercalcemia Secondary to Subcutaneous Fat Necrosis: A Diagnosis of Exclusion.

Authors:
Mary Whalen

Neonatal Netw 2019 Jul 8;38(4):236-241. Epub 2019 Jul 8.

Subcutaneous fat necrosis (SCFN) is a rare complication, usually occurring in otherwise healthy full-term infants who have experienced some level of trauma that causes ischemic injury to adipose tissue. Tissue injury usually occurs in areas of the body that are exposed to excessive pressure as during delivery. Tissue injury has also been described secondary to therapeutic cooling. Read More

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Use of Zoledronic Acid in a Neonate with Subcutaneous Fat Necrosis Complicated with Severe, Refractory Hypercalcemia.

Am J Perinatol 2019 07 25;36(S 02):S134-S138. Epub 2019 Jun 25.

U.O.C. Neonatologia - TIN - Nido, ARNAS Civico, Palermo, Italy.

Objective: Subcutaneous fat necrosis (SCFN) is a rare condition that may occur in the neonatal period. SCFN is an inflammatory disorder of the adipose tissue, usually found in full-term healthy infants who have a history of intrauterine or perinatal distress. It is usually a self-limited condition; however, in some cases, it can get complicated, leading to severe hypercalcemia that may be life-threatening. Read More

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[Nodular lesions in a newborn].

Rev Chil Pediatr 2019 Apr;90(2):229-231

Departamento de Dermatología, Hospital Universitari Son Espases, Palma de Mallorca, España.

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Subcutaneous Fat Necrosis of the Newborn.

Authors:
Mark Bernhardt

Skinmed 2019;17(1):63. Epub 2019 Mar 19.

From Private Practice, Fort Lauderdale, FL.

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Calcium management challenges in a macrosomic child with subcutaneous fat necrosis.

BMJ Case Rep 2019 Feb 19;12(2). Epub 2019 Feb 19.

Paediatric Dermatology, KK Women's and Children's Hospital, Singapore.

We present a case that illustrates the fluctuations in calcium levels to be expected while managing an infant with maternal gestational diabetes mellitus who also develops subcutaneous fat necrosis (SCFN). There is initial hypocalcaemia due to functional hypoparathyroidism, requiring judicious calcium replacement. But with increased extrarenal production of 1,25-dihydroxyvitamin D due to granulomatous inflammation of subcutaneous adipose tissue, hypercalcaemia ensues. Read More

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February 2019

Subcutaneous Fat Necrosis of the Newborn: Is Fine Needle Aspiration Cytology Diagnostic?

Acta Cytol 2019;63(1):75-77. Epub 2018 Dec 13.

Department of Paediatric Surgery, Chacha Nehru Bal Chikitsalaya, Delhi, India.

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Newborn With Enlarged Erythematous Mass on Back: Case Report and Review of Medical Literature.

Glob Pediatr Health 2018 1;5:2333794X18803552. Epub 2018 Oct 1.

Wayne State University, Detroit, MI, USA.

Newborn skin nodules are usually benign and self-resolving skin condition. Differential diagnosis of such lesions include cysts, hemangioma, abscess, cellulitis, sclerema neonatorum, subcutaneous fat necrosis, neurofibromatosis, benign tumors, or malignant tumors such as rhabdomyosarcoma, infantile fibrosarcoma, or neuroblastoma. We report a case of congenital subcutaneous fat necrosis in a 7-day-old baby presenting with multiple erythematous mass on back. Read More

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October 2018

Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature.

Pediatr Dermatol 2019 Jan 6;36(1):24-30. Epub 2018 Sep 6.

Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Subcutaneous fat necrosis of the newborn is an uncommon disorder, and although usually benign, associated hypercalcemia can lead to complications such as failure to thrive and renal failure. Many sources suggest screening for hypercalcemia for 6 months following resolution of skin lesions, but little data are available to support this recommendation. This study examines existing published literature to better guide practitioners regarding screening evaluations of asymptomatic patients with subcutaneous fat necrosis. Read More

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January 2019

Firm, Indurated Plaques After Therapeutic Hypothermia.

Clin Pediatr (Phila) 2018 10 9;57(12):1468-1471. Epub 2018 Jul 9.

2 Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

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October 2018

Subcutaneous fat necrosis in a neonate.

Arch Dis Child Educ Pract Ed 2019 10 3;104(5):248-249. Epub 2018 Jul 3.

Paediatrics, Oxford University Hospitals NHS Foundation Trust , Horton General Hospital, Banbury, UK.

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October 2019

Subcutaneous fat necrosis of the newborn: clinical and histopathological correlation.

An Bras Dermatol 2018 06;93(3):412-414

Department of Pathology, Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.

Subcutaneous fat necrosis of the newborn is a rare benign panniculitis found in term and post-term neonates. Diagnosis is based on clinical characteristics and specific alterations in the adipocytes, detected by anatomical pathology. Subcutaneous fat necrosis of the newborn can occur in uncomplicated pregnancy and childbirth. Read More

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