142,449 results match your criteria Subcutaneous Fat Necrosis of the Newborn
Med Sci Monit 2018 Dec 11;24:8977-8983. Epub 2018 Dec 11.
Department of Allergy and Immunology, Dr. Ersin Arslan Education and Research Hospital, Gaziantep, Turkey.
BACKGROUND Subcutaneous immunotherapy (SCIT) in allergic rhinitis (AR) and asthma is a very effective treatment, but adherence is still a serious problem. Studies addressing real-life adherence to SCIT are rare in the literature. The aim of this study was to evaluate the adherence to SCIT in AR and asthma. Read More
Oncol Res Treat 2018 Dec 12;42(1-2). Epub 2018 Dec 12.
Introduction: Breast cancer is responsible for more than 50% of cutaneous metastases. One of the treatment options is electrochemotherapy (ECT). It is an effective method of local tumor ablation through the application of electroporation. Read More
Obes Facts 2018 Dec 11;11(6):454-464. Epub 2018 Dec 11.
Clinic of Internal Medicine, Jessenius Faculty of Medicine in Martin (JFM CU), Comenius University in Bratislava, Bratislava, Slovakia.
Background: To report changes in body composition and biochemical parameters in patients with type 1 diabetes mellitus (T1D) after switching from multiple daily injection (MDI) to continuous subcutaneous insulin infusion (CSII).
Methods: 31 patients switched over from MDI to CSII. Body composition, biochemical parameters, glycaemic variability (GV) and level of physical activity were evaluated before and 6 months on CSII. Read More
Obes Facts 2018 Dec 11;11(6):475-490. Epub 2018 Dec 11.
Department of Medicine, University of Leipzig, Leipzig,
Background/aims: Altered expression and circulating levels of glutathione peroxidase 3 (GPX3) have been observed in obesity and type 2 diabetes (T2D) across species. Here, we investigate whether GPX3 serum concentrations and adipose tissue (AT) GPX3 mRNA expression are related to obesity and weight loss.
Methods: GPX3 serum concentration was measured in 630 individuals, including a subgroup (n = 293) for which omental and subcutaneous (SC) GPX3 mRNA expression has been analyzed. Read More
Obes Facts 2018 Dec 11;11(6):440-453. Epub 2018 Dec 11.
Nutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal,
Objective: This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and leptin in obese Wistar rats.
Methods: Three groups of obese rats were fed 10 days one of the following diets: Standard diet (Labina®) + water; High Glycemic Index and Load (HGLI) diet + water or HGLI diet + TTI. Read More
Int Immunopharmacol 2018 Dec 8;67:78-86. Epub 2018 Dec 8.
Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China. Electronic address:
Oxidative stress and neuroinflammation are thought to be the two key early events during the process of mild cognitive impairment (MCI). Therefore, effective regulation of oxidative stress and neuroinflammation is an important aspect of preventing and improving MCI. We previously found that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, markedly reduced cognitive impairment in APP/PS1 mice and oAβ-injected mice. Read More
Diabetes Obes Metab 2018 Dec 9. Epub 2018 Dec 9.
Department of Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital Ljubljana, and Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Aims: To evaluate the efficacy and safety of fast-acting insulin aspart (faster aspart [FA]) vs insulin aspart (IAsp) in continuous subcutaneous insulin infusion (CSII) in participants with type 1 diabetes.
Materials And Methods: Double-blind, treat-to-target, randomized, 16-week trial investigating CSII treatment with FA (n = 236) or IAsp (n = 236). All available information regardless of treatment discontinuation was used for the evaluation of effect. Read More
J Clin Pharmacol 2018 Dec 11. Epub 2018 Dec 11.
Global Clinical Pharmacology, Janssen Research & Development, LLC, Spring House, PA, USA.
Population pharmacokinetics (PK) and exposure-response (E-R) analyses were conducted to compare the PK and E-R relationships of golimumab between children and adults with ulcerative colitis. PK data following subcutaneous golimumab administration to children with ulcerative colitis (6-17 years) in the PURSUIT-PEDS-PK study, adults with ulcerative colitis in the PURSUIT study, and children with pediatric polyarticular juvenile idiopathic arthritis (2-17 years) in the GO-KIDS study, were included in the population PK analysis. E-R analysis was conducted using logistic regression to link serum golimumab concentration and Mayo score-based efficacy outcomes in pediatric and adult ulcerative colitis. Read More
J Tissue Eng Regen Med 2018 Dec 7. Epub 2018 Dec 7.
Institute of Biomaterials, University of Erlangen-Nuremberg, Erlangen, Germany.
Recent studies have demonstrated that surface characteristics, porosity, and mechanical strength of three-dimensional (3D) 45S5-type bioactive glass (BG)-based scaffolds are directly correlated with osteogenic properties. 3D-BG-scaffolds obtained from maritime natural sponges (MNS) as sacrificial templates exhibit the required morphological properties; however, no in-vivo data about the osteogenic features is available. In this study, uncoated (group A) and gelatin-coated (group B) crystalline MNS-obtained BG-scaffolds were evaluated mechanically and seeded with human mesenchymal stem cells prior to subcutaneous implantation in immunodeficient mice. Read More
J Clin Pharmacol 2018 Dec 11. Epub 2018 Dec 11.
Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hepatocyte growth factor is an endogenous pleiotropic factor shown to act as a potent neuroprotectant against disease progression in animal models of amyotrophic lateral sclerosis, which is a devastating, adult-onset motor neuron disease. To evaluate the safety, tolerability, and pharmacokinetics of recombinant 5-residue-deleted human hepatocyte growth factor (KP-100) injected intrathecally through an implantable catheter connected to a subcutaneous port, we conducted a first-in-human phase I trial of intrathecal KP-100 in 15 Japanese patients with amyotrophic lateral sclerosis. The regimen was a single injection of 3 escalating doses (0. Read More
Physiol Rep 2018 Dec;6(23):e13940
Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Age-related alterations in whole body composition, particularly, reduced fat free mass (FFM) and increased fat mass (FM), lead to a progressive decline in resting energy expenditure (REE). Similarly, regional body composition and fat distribution changes with age might also contribute to an overall lower REE. This study investigated the influence of age on REE, regional body composition and fat distribution, including subcutaneous fat (SF) and visceral fat (VF), in a Chinese Han population as well as their contributions to age-related changes in REE. Read More
Transfusion 2018 Dec;58 Suppl 3:3065-3071
InflaRx, Jena, Germany.
Background: To ensure that immunoglobulin (Ig) products have adequate functional antibody, the US Food and Drug Administration (FDA) requires that Ig lots contain minimum levels of measles neutralizing antibody; the current minimum is 0.48 x US Reference Ig 176.
Study Design And Methods: In the first part of the study, measles antibody titers were measured in donor plasma samples collected in 2007, 2011, and 2017. Read More
Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7807-7818
Department of Neurosurgery, Dezhou People's Hospital, Dezhou, Shandong, China.
Objective: Glioblastomas are one of the most dangerous types of malignancies because of their metastatic capacity and challenge to treat with chemotherapy or radiotherapy. Hence, detailed research to explain the molecular mechanisms of glioblastoma metastasis is crucial to improve glioblastoma treatment.
Patients And Methods: The expression level of fatty acid-binding protein 4 (FABP4) in glioblastoma cell lines and tissues was detected by Western blotting and quantitative Real-time polymerase chain reaction (qRT-PCR) assays. Read More
Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7716-7725
Department of Gastroenterology, First Affiliated Hospital of Henan University of TCM, Henan, China.
Objective: The purpose of this project was to investigate the expression of Dishevelled-3 (Dvl3) in esophageal squamous cell carcinoma and cultured cells, and to determine the consequence of Dvl3 silencing in the tumorous properties of esophageal squamous cell carcinoma cells.
Patients And Methods: The expression of Dvl3 mRNA and protein in 50 cases of esophageal squamous cell carcinoma was detected. The expression of Dvl3 mRNA and protein was significantly elevated in esophageal squamous cell carcinoma tissues compared with atypical hyperplasia and normal esophageal mucosa. Read More
Adv Ther 2018 Dec 7. Epub 2018 Dec 7.
Amgen Ltd, Uxbridge, UK.
Introduction: Talimogene laherparepvec is a first-in-class oncolytic immunotherapy for intratumoral injection with proven efficacy and tolerability in patients with unresectable early metastatic melanoma (stage IIIB-IVM1a) in the pivotal phase III OPTiM study. The objective was to characterize melanoma patients treated with talimogene laherparepvec in routine clinical practice in Germany.
Methods: A retrospective chart review was conducted in unresectable stage IIIB-IVM1a melanoma patients. Read More
Forensic Sci Med Pathol 2018 Dec 7. Epub 2018 Dec 7.
Institute of Forensic Medicine, University of Belgrade - School of Medicine, 31a Deligradska str, Belgrade, 11000, Serbia.
Fat embolism is markedly underdiagnosed, even though it is a well-known phenomenon following fractures of the long bones, injury to subcutaneous fat tissue, rupture of a fatty liver, surgical operations on fatty tissues, septicemia, burns and barotrauma. Forensic pathologists tend to "simplify" autopsy report conclusion in cases with multiple injuries where fat embolism and exsanguination could be considered to be the concomitant causes of death. Herein we present a case of 24-year-old male who was beaten with a metal rod by several persons. Read More
Adv Ther 2018 Dec 10. Epub 2018 Dec 10.
Taisho Pharmaceutical Co., Ltd., Tokyo, Japan.
Introduction: Orlistat is an inhibitor of pancreatic lipase and is used as an anti-obesity drug in many countries. However, there are no data available regarding the effects of orlistat on visceral fat accumulation in Japanese subjects. Therefore, this comparative, placebo-controlled, double-blind, randomized study aimed to evaluate the efficacy and safety of orlistat in Japanese participants with excessive visceral fat accumulation and without dyslipidemia, diabetes mellitus, and hypertension ("metabolic diseases"). Read More
Eur Arch Otorhinolaryngol 2018 Dec 7. Epub 2018 Dec 7.
Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Objective: To present long-term data on the Wide Ponto implant bone-anchored hearing system (BAHS) in regards to implant stability, soft tissue reaction and implant loss for two case series undergone either the tissue reduction- or the tissue preservation surgical technique.
Methods: Comparison of two consecutive, prospective case series. Each case series enrolled 24 patients. Read More
Cancer Chemother Pharmacol 2018 Dec 8. Epub 2018 Dec 8.
Endocrinology, DiMI and CEBR, University of Genoa, Genoa, Italy.
Purpose: Octreotide SC depot is a novel, ready-to-use formulation administered via a thin needle. In a phase 1 study in healthy volunteers, this formulation provided higher bioavailability of octreotide with faster onset and stronger suppression of IGF-1 in healthy volunteers versus long-acting intramuscular (IM) octreotide. This phase 2 study evaluated the pharmacokinetics, efficacy, and safety of octreotide SC depot in patients with acromegaly and functioning NETs, previously treated with octreotide IM. Read More
Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.
Department of Rheumatology and Immunology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Rev Med Chil 2018 Aug;146(8):938-942
Departamento de Dermatología, Pontificia Universidad Católica de Chile, Santiago, Chile.
Ehlers Danlos Syndrome comprises a heterogeneous group of genetic disorders of the connective tissue, due to defects in collagen or its modifying enzymes. We report a 21 years old male presenting with translucent skin revealing the subcutaneous venous pattern. He had a thin face, large-appearing eyes, thin lips, thin nose, joint hypermotility and history of hip dysplasia. Read More
Rom J Morphol Embryol 2018 ;59(3):917-926
Department of Histology, University of Medicine and Pharmacy of Craiova, Romania;
Pilomatricoma is a benign skin tumor originating from the matrix cells of the hair follicles. Sometimes, its diagnosis can be difficult, especially in the preauricular region, where in the differential diagnosis, in addition to other dermal and subcutaneous masses, primary and secondary parotid gland tumor lesions must be also considered. A 34-year-old female was referred to our Institution with a right preauricular swelling over 12 months, which enlarged in the last two months. Read More
Plast Reconstr Surg Glob Open 2018 Oct 16;6(10):e1970. Epub 2018 Oct 16.
Long Island Plastic Surgical Group, PC, Garden City, New York, N.Y.
Background: Buccal fat pad excision is offered as a means of obtaining a more aesthetic midface. This procedure has been documented in the form of countless videos on Instagram and other social media platforms with no long-term patient follow-up. We performed a retrospective analysis of published data regarding buccal fat pad excision and sought to better elucidate pitfalls regarding this underreported procedure. Read More
Nurs Open 2019 Jan 28;6(1):126-135. Epub 2018 Aug 28.
AARA Research Center Dallas Texas.
Aims: The aim of this study was to provide recommendations for training patients with hereditary angioedema, based on nursing clinical trial experience, to self-administer subcutaneous C1-INH (C1-INH[SC]) used as routine prophylaxis.
Background: A volume-reduced, subcutaneous C1-INH concentrate (C1-INH(SC); HAEGARDA®; CSL Behring) was recently FDA-approved for the routine prevention of hereditary angioedema attacks. Nurses will play an important role in patient training. Read More
Front Neurol 2018 26;9:971. Epub 2018 Nov 26.
Department of Neurology, University Hospital Regensburg, Regensburg, Germany.
To evaluate safety, tolerability and feasibility of long-term treatment with Granulocyte-colony stimulating factor (G-CSF), a well-known hematopoietic stem cell factor, guided by assessment of mobilized bone marrow derived stem cells and cytokines in the serum of patients with amyotrophic lateral sclerosis (ALS) treated on a named patient basis. 36 ALS patients were treated with subcutaneous injections of G-CSF on a named patient basis and in an outpatient setting. Drug was dosed by individual application schemes (mean 464 Mio IU/month, range 90-2160 Mio IU/month) over a median of 13. Read More
J Cutan Aesthet Surg 2018 Jul-Sep;11(3):132-135
Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany.
Background: Mondor's disease of the subcutaneous veins of the breast is an uncommon disorder. The etiology of Mondor's disease remains unclear. Usually, it is a self-limited disease. Read More
J Cutan Aesthet Surg 2018 Jul-Sep;11(3):105-109
Division of Plastic and Reconstructive Surgery, McGill University, Montreal, Quebec, Canada.
Currently, no reliable gold standard exists for the objective outcome measurement following liposuction. The purpose of this systematic review was to summarize reported methods of monitoring liposuction results by objectively measuring subcutaneous adipose tissue. A systematic literature search was performed to identify relevant articles that described techniques for objectively quantifying adipose tissue following traditional liposuction. Read More
Med Mycol Case Rep 2019 Mar 25;23:31-33. Epub 2018 Oct 25.
Laboratorio de Micologia y Fitopatologia (LAMFU), Departamento de Ciencias Biológicas, Facultad de ciencias, Universidad de los Andes, Bogota 111711, Colombia.
Chromoblastomycosis is a chronic cutaneous and subcutaneous mycosis, is caused by dematiaceous fungi, the most frequently implicated are and We report a woman who was treated before with mycological cure, but she experience a relapse requiring treatment again. Direct microscopic examination and skin biopsy with culture were necessary to identify a Exophiala psychrophila, and for our knowledge this is the first case reported. Read More
Case Rep Surg 2018 7;2018:1795028. Epub 2018 Nov 7.
Department of Surgery, Faculty of Medicine, University of Colombo, Sri Lanka.
This case highlights the rare occurrence of a large benign calcified nodule of the left lobe of the thyroid gland with associated obstructive symptoms. Unusually, the calcification was confluent with similar calcified nodules in the subcutaneous tissue plane. The symptoms were alleviated following a total thyroidectomy. Read More
J Obes 2018 8;2018:7108075. Epub 2018 Nov 8.
Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University Innsbruck, Innsbruck 6020, Austria.
Introduction: Obesity and related nonalcoholic fatty liver disease (NAFLD) are an emerging health care issue that imposes substantial morbidity to individuals. Growth and differentiation factor 15 () limits food uptake, body weight, and energy balance by modulation of GDNF-family receptor -like (GFRAL) signalling in the hindbrain. However, the regulation of expression in obesity and NAFLD is incompletely understood. Read More
Onco Targets Ther 2018 14;11:8153-8163. Epub 2018 Nov 14.
Department of Breast and Thyroid Surgery, Breast Cancer Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, People's Republic of China,
Background: Most breast cancers are estrogen dependent and were sensitive to endocrine therapy, and genistein (GEN) shows strong affinity with human oestrogen receptor beta (ERβ).
Purpose: The present study aimed to investigate the anticancer activity of GEN in breast cancer cell lines that constitutively expressing ERβ1 in vitro and in vivo.
Methods: MCF-7/ERβ1 and MDA-MB-231/ERβ1 cell sub-lines were established through lentiviral infection. Read More
Onco Targets Ther 2018 14;11:8107-8115. Epub 2018 Nov 14.
The Institute of Audiology and Speech Science of Xuzhou Medical College, Xuzhou 221002, People's Republic of China,
Background: Follicle-stimulating hormone (FSH) has multiple biological functions. It is currently considered that FSH can inhibit cervical cancer, and our aim was to explore the underlying molecular mechanisms.
Materials And Methods: An in vivo experiment using nude mice injected with HeLa cells was performed. Read More
PLoS Negl Trop Dis 2018 Dec 7;12(12):e0006968. Epub 2018 Dec 7.
Académie des Sciences, 23 Quai de Conti, Paris, France.
Background: Urinary schistosomiasis, the result of infection by Schistosoma haematobium (Sh), remains a major global health concern. A schistosome vaccine could represent a breakthrough in schistosomiasis control strategies, which are presently based on treatment with praziquantel (PZQ). We report the safety and efficacy of the vaccine candidate recombinant 28-kDa glutathione S-transferase of Sh (rSh28GST) designated as Bilhvax, in a phase 3 trial conducted in Senegal. Read More
PLoS Negl Trop Dis 2018 Dec 10;12(12):e0007019. Epub 2018 Dec 10.
The Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.
Mycetoma is a neglected tropical disease endemic in tropical and subtropical countries, particularly Sudan. The disease is characterised by the triad of painless subcutaneous mass, multiple sinuses and discharge that contain grains. It is a chronic, debilitating disease most commonly affecting the feet or hands and leads to substantial morbidity, loss of function and even amputation. Read More
Angiol Sosud Khir 2018 ;24(4):81-87
Department of Surgery, Institute of Additional Professional Education, South Ural State Medical University of the RF Ministry of Public Health, Chelyabinsk, Russia.
The purpose of this study was to assess the incidence of the development of symptoms of damage to subcutaneous nerves after endovenous laser coagulation (EVLC) of the great saphenous vein (GSV), as well as to determine the effect of these symptoms on quality of life (QoL) of patients. Our retrospective study enrolled a total of 119 patients (mean age 50±13.9 years) subjected to 151 isolated EVLC of the GSV. Read More
Plast Reconstr Surg 2018 Nov 26. Epub 2018 Nov 26.
Tissue Engineering and Wound Healing Laboratory, Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital-Harvard Medical School, Boston, USA.
Introduction: External Volume Expansion (EVE) promotes angiogenesis in tissues by inducing a sub-critical hypoxia, mechanically stimulating endothelia, and creating mild inflammation. Application of EVE to less-vascularized tissues with endothelial cell dysfunction (ECD) (e.g. Read More
J Neonatal Perinatal Med 2018 Dec 1. Epub 2018 Dec 1.
Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA, USA.
A 710 g male infant was born at a referring hospital at a gestational age of 23 weeks and 2 days via vaginal delivery and was transferred to our facility at 14 days of age. His delivery was complicated by the breech presentation with difficult head extraction. The infant's initial course was significant for respiratory distress syndrome, grade III-IV intraventricular hemorrhage (IVH), acute kidney injury, and large PDA. Read More
J Back Musculoskelet Rehabil 2018 Nov 30. Epub 2018 Nov 30.
Department of Anatomy, Faculty of Medicine, Cukurova University, Sarıçam, Adana, Turkey.
Objective: The aim of this study was to determine the prerequisite physical features of classical ballet education.
Methods: Students who enrolled and were rejected for the applications of State Conservatory Ballet Main Art Branch in the academic year 2013-2014 and 2014-2015 were compared with their exam results. This study involves defining the physical ability and determining physical fitness by using Eurofit tests including the Flamingo Balance test (FB), Plate Tapping (PT), Sit and Reach (SITR), Standing Broad Jump (SBJ), Handgrip test (HG), Sit Up in 30 Seconds (SU) and Shuttle Run 10 × 5 meter (SR), Heath-Carter somatotyping method and anthropometric measurements which determine ballet students' body type and physical abilities. Read More
J Pediatr Endocrinol Metab 2018 Dec 7. Epub 2018 Dec 7.
Division of Critical Care Medicine, Children's National Health System, Washington, DC, USA.
Background Standard therapy of diabetic ketoacidosis (DKA) in pediatrics involves intravenous (IV) infusion of regular insulin until correction of acidosis, followed by transition to subcutaneous (SC) insulin. It is unclear what laboratory marker best indicates correction of acidosis. We hypothesized that an institutional protocol change to determine correction of acidosis based on serum bicarbonate level instead of venous pH would shorten the duration of insulin infusion and decrease the number of pediatric intensive care unit (PICU) therapies without an increase in adverse events. Read More
J Endocrinol 2019 Feb;240(2):271-286
Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are an ideal therapy for type 2 diabetes and, as of recently, for obesity. In contrast to visceral fat, subcutaneous fat appears to be protective against metabolic diseases. Here, we aimed to explore whether liraglutide, a GLP-1RA, could redistribute body fat via regulating lipid metabolism in different fat depots. Read More
Diabetes 2018 Dec 7. Epub 2018 Dec 7.
Diabetes Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Visceral obesity is associated with insulin resistance and higher risk of type 2 diabetes and metabolic diseases. A limited ability of adipose tissues to remodel through the recruitment and differentiation of adipose stem cells (ASCs) is associated with adipose tissue inflammation and fibrosis and the metabolic syndrome. We show that the lower adipogenesis of omental (Om) compared to abdominal subcutaneous (Abdsc) ASCs was associated with higher secretion of TGFβ ligands that acted in an autocrine/paracrine loop to activate SMAD2 and suppress adipogenesis. Read More
EMBO Rep 2018 Dec 10. Epub 2018 Dec 10.
Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, AG&M, University of Amsterdam, Amsterdam, The Netherlands
During the suckling-to-weaning transition, the intestinal epithelium matures, allowing digestion of solid food. Transplantation experiments with rodent fetal epithelium into subcutaneous tissue of adult animals suggest that this transition is intrinsically programmed and occurs in the absence of dietary or hormonal signals. Here, we show that organoids derived from mouse primary fetal intestinal epithelial cells express markers of late fetal and neonatal development. Read More
J Investig Allergol Clin Immunol 2018 Dec;28(6):430-432
Department of Allergy, Fundación Jimenez Diaz, Madrid. Department of Medicine, Universidad Autónoma de Madrid, CIBERES, Instituto Carlos III, Madrid, Spain.
Nanomedicine 2018 Dec 7. Epub 2018 Dec 7.
Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of the Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
Recently, tumor neoantigens have been attractive for development of personal therapeutic vaccines. However, how to instantly deliver multiple neoantigens for efficient anti-tumor immunity is still challenging. Here, we established a SpyCatcher-modified ferritin nanoparticle platform, which permits convenient and stable covalent conjugation with tumor specific antigens containing SpyTag in a click-link manner. Read More
J Control Release 2018 Dec 7. Epub 2018 Dec 7.
Pathophysiological and Health Science Team, Imaging Platform and Innovation Group, Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan. Electronic address:
In vivo biodistribution analyses, especially in tumors, of nucleic acids delivered with nanoparticles are important to develop drug delivery technologies for medical use. We previously developed wrapsome® (WS), an ~100 nm liposomal nanoparticle that can encapsulate siRNA, and reported that WS accumulates in tumors in vivo and inhibits their growth by an enhanced permeability and retention effect. In the present study, we evaluated the pharmacokinetics of nucleic acid-containing nanoparticles by combining dynamic positron emission tomography (PET) imaging and liquid chromatography-tandem mass spectrometry (LC/MS/MS) analysis. Read More
J Hepatol 2018 Dec 7. Epub 2018 Dec 7.
Pinnacle Clinical Research, Live Oak, TX, United States.
Background: NGM282, an engineered analogue of the gut hormone FGF19, improves hepatic steatosis and fibrosis biomarkers in patients with nonalcoholic steatohepatitis (NASH). However, NGM282 increases serum cholesterol levels by inhibiting CYP7A1, which encodes the rate-limiting enzyme in the conversion of cholesterol to bile acids. Here, we investigate whether administration of a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor can manage the cholesterol increase seen in NASH patients treated with NGM282. Read More
Int J Biol Macromol 2018 Dec 5. Epub 2018 Dec 5.
College of Marine Life Science, Ocean University of, China. Electronic address:
Cell therapy with bone marrow-derived mesenchymal stem cells (BMSCs) is a potential method for many disease treatments, including keloid. In the present study, an Arg-Gly-Asp (RGD) modified hydroxybutyl chitosan (HBC) hydrogel (HBC-RGD) was developed to enhance the adhesion and proliferation of BMSCs within the hydrogel. The successful synthesis of HBC-RGD was confirmed by FTIR and H NMR. Read More
Adv Drug Deliv Rev 2018 Dec 5. Epub 2018 Dec 5.
Department of Chemical Engineering, Institute of Biomedical Engineering, and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan (ROC). Electronic address:
The encapsulation of insulin in micro- or nanodelivery systems may eliminate the need for frequent subcutaneous injections, improving the quality of life of diabetic patients. Formulations for oral, intranasal, pulmonary, subcutaneous, and transdermal administration have been developed. The use of stimuli-responsive polymeric carriers that can release the encapsulated drug in response to changes of the environmental stimuli or external activation enables the design of less invasive or non-invasive systems for smart insulin delivery from depots in the body. Read More
Acta Trop 2018 Dec 6. Epub 2018 Dec 6.
ICBS- Instituto de Ciências Biológicas e da Saúde, UFMT- Universidade Federal de Mato Grosso, Barra do Garças, Mato Grosso, Brazil. Electronic address:
Strongyloidiasis is an intestinal parasitosis that occurs in humans infected by Strongyloides stercoralis mostly. At its acute phase, symptoms like constipation, diarrhea and abdominal pain can be observed, but become asymptomatic for a long time, until an immunosuppression will start a hyperinfection and the dissemination of the disease, prevalent on the elderly population in tropical countries. Ivermectina treatment is the currently choice for this disease, due to its great efficacy and the results reported. Read More
Adv Drug Deliv Rev 2018 Dec 7. Epub 2018 Dec 7.
Department of Bioengineering, University of California, Los Angeles, CA 90095, USA; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; California NanoSystems Institute, Jonsson Comprehensive Cancer Center, Center for Minimally Invasive Therapeutics, University of California, Los Angeles, CA 90095, USA.. Electronic address:
Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the standard route of insulin delivery, it may be associated with pain, needle phobia, and decreased adherence, as well as the risk of infection. Therefore, transdermal insulin delivery has been widely investigated as an attractive alternative to subcutaneous approaches for diabetes management in recent years. Read More