34,420 results match your criteria Subcorneal Pustular Dermatosis


Association of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population.

Br J Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Background/aims: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of diseases that cause an acute vesiculobullous reaction in the skin and mucous membranes. The occurrence of these diseases is associated with various drugs, a large proportion of which is comprised cold medicines (CM). We try to investigate the association between human leucocyte antigen (HLA) class I genes and CM-related SJS/TEN (CM-SJS/TEN) with severe ocular complications (SOC) in the Korean population. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313263DOI Listing
January 2019
1 Read

Lacrimal passage irrigation in children with Stevens-Johnson syndrome or toxic epidermal necrolysis: a five-year retrospective study.

BMC Ophthalmol 2019 Jan 18;19(1):22. Epub 2019 Jan 18.

Department of Ophthalmology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China.

Background: To identity the effect of lacrimal system irrigation in the acute stage in children with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).

Methods: A retrospective review of 39 patients with SJS or TEN from 2012 to 2017 was analyzed. Patients were divided into two subgroups according to whether they received irrigation in the acute stage. Read More

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http://dx.doi.org/10.1186/s12886-018-1014-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339389PMC
January 2019
3 Reads

Venom concentrations in blisters and hemorrhagic bullae in a patient bitten by a Taiwan habu (Protobothrops mucrosquamatus).

Rev Soc Bras Med Trop 2019 Jan 17;52:e20180160. Epub 2019 Jan 17.

Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.

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http://dx.doi.org/10.1590/0037-8682-0160-2018DOI Listing
January 2019
2 Reads

Pentoxyfilline as a treatment for subcorneal pustular dermatosis.

Dermatol Ther 2019 Jan 14:e12818. Epub 2019 Jan 14.

Department of Dermatology, West Virginia University School of Medicine, Morgantown, West Virginia.

Subcorneal pustular dermatosis (SPD) is a rare pustular neutrophilic dermatosis in which groups of sterile pustules appear in the superficial (subcorneal) skin. This chronic condition can be associated with significant morbidity and decreased quality of life. Dapsone is the first-line therapy for SPD, but some patients fail to respond or cannot tolerate it. Read More

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http://doi.wiley.com/10.1111/dth.12818
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http://dx.doi.org/10.1111/dth.12818DOI Listing
January 2019
6 Reads

Entirely thoracoscopic resection of a giant emphysematous bulla.

Pan Afr Med J 2018 6;30:247. Epub 2018 Aug 6.

British Hospital of Buenos Aires, Buenos Aires, Argentina.

A 38-year-old man with longilinear shape, smoker (38 packs/year) and no other relevant medical history was referred to our department due to the finding of left pulmonary hyperlucency on a chest x-ray. A computed tomography (CT) was performed and a giant emphysematous bulla with thin-walled partitions inside was shown that replaced almost the entire left upper lobe, The patient underwent an exploratory thoracoscopy. Intraoperatively a giant bulla was seen that initially impressed to replace the entire upper lobe. Read More

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http://www.panafrican-med-journal.com/content/article/30/247
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http://dx.doi.org/10.11604/pamj.2018.30.247.12400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307922PMC
January 2019
8 Reads

Feline pemphigus foliaceus: original case series and a comprehensive literature review.

BMC Vet Res 2019 Jan 9;15(1):22. Epub 2019 Jan 9.

Murdoch University Veterinary Hospital, School of Veterinary and Biomedical Science, Murdoch University, Murdoch, WA, Australia.

Background: Since the first description of feline pemphigus foliaceus (PF) more than 30 years ago, numerous case reports have been published, while larger case series have remained rare. This large body of information, if extrapolated, could address clinical discrepancies and expand our knowledge about the treatment of feline PF. This manuscript reviews cases of feline PF published between 1950 and 2016 and adds additional 35 original cases to provide further insight into the clinical aspect and treatment outcome of this disease. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
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http://dx.doi.org/10.1186/s12917-018-1739-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327590PMC
January 2019
12 Reads

Neutrophilic Dermatosis in Pregnancy: An Uncommon Course.

Open Access Maced J Med Sci 2018 Dec 18;6(12):2393-2394. Epub 2018 Dec 18.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Pyoderma gangrenosum (PG) is a neutrophilic-mediated inflammatory skin disease characterised by the rapid onset of painful, hemorrhagic pustules developing into necrotic ulcers occurring predominantly in women aged 20-50 years. According to the literature, all patients reported no change or worsening of the disease during pregnancy. We herein present the case of a 34-year-old woman that developed a neutrophilic dermatosis of the hand reporting complete resolution of the skin disease during pregnancy. Read More

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http://dx.doi.org/10.3889/oamjms.2018.453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311494PMC
December 2018

Epidermal bulla: A dermatology complication of radial artery compression band.

Indian Heart J 2018 Dec 2;70 Suppl 3:S486-S488. Epub 2018 Aug 2.

Institute of Cardio-Vascular Diseases, The Madras Medical Mission Hospital, Chennai, Tamilnadu, India.

Patent hemostasis technique is used with the trans radial (TR) band to prevent radial artery occlusion following diagnostic coronary angiogram or percutaneous coronary intervention using radial artery access. We report epidermal bulla as a complication of TR band usage and a modified patent hemostasis technique using barbeau test to prevent this complication. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309565PMC
December 2018

Successful Treatment of Pemphigus Vulgaris With Ofatumumab

J Drugs Dermatol 2018 Dec;17(12):1338-1339

Rituximab is a chimeric anti-CD20 monoclonal antibody that is very effective in treating patients with pemphigus vulgaris. Though infrequent, the development of human anti-chimeric antibodies in patients receiving rituximab results in loss of efficacy. Ofatumumab is a second-generation fully-human anti-CD20 monoclonal antibody currently used to treat chronic lymphocytic leukemia. Read More

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December 2018
4 Reads

[Pemphigus vulgaris in pediatrics: A case report].

Rev Chil Pediatr 2018 Oct;89(5):650-654

Asociación Española, Montevideo, Uruguay.

Introduction: pemphigus vulgaris is a serious and infrequent disease in children. Its timely diagnosis and treatment allows modifying its prognosis. The objective is to describe its clinical characteristics, and the diagnostic and therapeutic approach of this uncommon autoimmune blistering disease in children. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000708DOI Listing
October 2018
1 Read

Successful treatment of hemorrhagic bullous Henoch-Schonlein purpura with intravenous immunoglobulins.

Pediatr Dermatol 2019 Jan 18;36(1):e34-e36. Epub 2018 Dec 18.

Department of Paediatrics, Santobono-Pausilipon Children's Hospital, Naples, Italy.

Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis in childhood. There is no consensus about the management for isolated cutaneous manifestations in HSP. We describe a case of HSP presenting with severe skin lesions that did not respond to standard therapy with corticosteroids. Read More

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http://dx.doi.org/10.1111/pde.13715DOI Listing
January 2019
1 Read

Targeted next-generation sequencing identifies a novel mutation of LAMB3 in a Chinese neonatal patient presented with junctional epidermolysis bullosa.

Medicine (Baltimore) 2018 Dec;97(49):e13225

Department of Obstetrics and Gynecology, Wuhan Medical & Health Center for Women and Children, Wuhan, Hubei.

Rationale: Epidermolysis bullosa (EB) refers to a group of rare inherited mechanobullous disorders that present with great clinical and genetic heterogeneity. Its severity ranges from mild blistering to life-threatening. However, the clinical symptoms of different types of EB overlap significantly, especially at an early stage. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812070-0001
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http://dx.doi.org/10.1097/MD.0000000000013225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310585PMC
December 2018
5 Reads

Epidermolysis bullosa simplex-generalized severe type due to keratin 5 p.Glu477Lys mutation: Genotype-phenotype correlation and in silico modeling analysis.

Pediatr Dermatol 2019 Jan 4;36(1):132-138. Epub 2018 Dec 4.

Epidermolysis Bullosa Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background/objectives: Epidermolysis bullosa is a group of diseases caused by mutations in skin structural proteins. Availability of genetic sequencing makes identification of causative mutations easier, and genotype-phenotype description and correlation are important. We describe six patients with a keratin 5 mutation resulting in a glutamic acid to lysine substitution at position 477 (p. Read More

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http://dx.doi.org/10.1111/pde.13722DOI Listing
January 2019
2 Reads

Toxic epidermal necrolysis after yellow fever vaccination.

An Bras Dermatol 2018 Nov/Dec;93(6):942-943

Medical Residency Program in Dermatology, Faculdade de Medicina de Jundiaí, Jundiaí (SP), Brazil.

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http://dx.doi.org/10.1590/abd1806-4841.20188237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256206PMC
February 2019
2 Reads

Treatment of oral manifestations of toxic epidermal necrolysis with low-level laser therapy in a pediatric patient.

Pediatr Dermatol 2019 Jan 26;36(1):e27-e30. Epub 2018 Nov 26.

Department of Oral Surgery and Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Drug-induced reactions are complications associated with high mortality and significant morbidity. Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of these conditions, which are characterized by skin and mucous lesions. Here, we report a case of a 9-year-old girl who presented with blisters associated with an extensive vesicular rash and multiple ulcerations on the lips and oral cavity. Read More

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http://doi.wiley.com/10.1111/pde.13719
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http://dx.doi.org/10.1111/pde.13719DOI Listing
January 2019
12 Reads

Trace element profile in pemphigus foliaceus and in pemphigus vulgaris patients from Southeastern Brazil.

J Trace Elem Med Biol 2019 Jan 24;51:31-35. Epub 2018 Sep 24.

Laboratory of the Division of Dermatology, University Hospital, Ribeirão Preto Medical School, Avenida Bandeirantes, 3900, 14049-900, Ribeirão Preto, São Paulo, Brazil.

Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are autoimmune bullous diseases; they are endemic in the northeastern region of the state of São Paulo, Southeastern Brazil. Patients' copper (Cu), zinc (Zn), and selenium (Se) metabolic deficiencies have already been associated with PV pathogenesis in the Middle East but not in Brazil. Lead (Pb), Cu, Zn, and Se concentrations were determined in whole blood or serum samples obtained from 56 PV patients, 62 PF patients, and 135 healthy controls from the endemic region and compared. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.09.005DOI Listing
January 2019
6 Reads

First reported case of thrombocytopenia from a Heterodon nasicus envenomation.

Toxicon 2019 Jan 19;157:12-17. Epub 2018 Nov 19.

Rocky Mountain Poison and Drug Center - Denver Health and Hospital Authority, Denver, CO, USA.

Context: The vast majority of the 2.5 million annual worldwide venomous snakebites are attributed to Viperidae or Elapidae envenomations. Of the nearly 2000 Colubridae species described, only a handful are known to cause medically significant envenomations. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.11.295DOI Listing
January 2019
2 Reads

Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases.

Pharmacol Res Perspect 2018 12 8;6(6):e00438. Epub 2018 Nov 8.

Department of Dermatology, Allergy, and Venereology University of Lübeck Lübeck Germany.

ω3-polyunsaturated free fatty acids (ω3-PUFAs), particularly docosahexaenoic (DHA) and eicosapentaenoic acid (EPA), are thought to exert health promoting effects in metabolic and in inflammatory diseases. The molecular mechanisms of these beneficial effects are only partially understood. DHA and EPA activate (GPR120/FFA4). Read More

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http://doi.wiley.com/10.1002/prp2.438
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http://dx.doi.org/10.1002/prp2.438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223243PMC
December 2018
8 Reads

Safety of Topical Calcineurin Inhibitors for Hailey-Hailey Disease-Reply.

JAMA 2018 09;320(11):1200-1201

Department of Dermatology, University of Texas Health Science Center at Houston.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.9558DOI Listing
September 2018
7 Reads

Safety of Topical Calcineurin Inhibitors for Hailey-Hailey Disease.

Authors:
Fei Han

JAMA 2018 09;320(11):1200

Department of Dermatology, Suqian First Hospital, Suqian City, Jiangsu Province, China.

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http://dx.doi.org/10.1001/jama.2018.9554DOI Listing
September 2018
1 Read

Reply to: "Comment on 'Oral diabetes medications other than dipeptidyl peptidase-4 inhibitors are not associated with bullous pemphigoid: A Finnish nationwide case control study'".

J Am Acad Dermatol 2018 12;79(6):e113-e114

PEDEGO Research Unit, University of Oulu, Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.

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http://dx.doi.org/10.1016/j.jaad.2018.06.042DOI Listing
December 2018
8 Reads

Comment on "Oral diabetes medications other than dipeptidyl peptidase-4 inhibitors are not associated with bullous pemphigoid: A Finnish nationwide case control study".

Authors:
Khalaf Kridin

J Am Acad Dermatol 2018 12;79(6):e111-e112

Department of Dermatology, Rambam Health Care Campus, Haifa, Israel and the School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183219
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http://dx.doi.org/10.1016/j.jaad.2018.06.043DOI Listing
December 2018
12 Reads

Propranolol eye drops in patients with corneal neovascularization.

Medicine (Baltimore) 2018 Nov;97(45):e13002

Pediatric Ophthalmology Unit, Niguarda Ca' Granda Metropolitan Hospital, Milan, Italy.

Rationale: Studies performed in animal models of corneal neovascularization suggested the possible efficacy of a treatment with propranolol. Corneal neovascularization is one of the most feared complications of Stevens-Johnson syndrome that frequently involves ocular surface. We report the first 2 patients with severe ocular neo-vascularization treated with different degrees of success, with propranolol eye drops. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811090-0001
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http://dx.doi.org/10.1097/MD.0000000000013002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250516PMC
November 2018
18 Reads

[Acute papulopustular eruption of the face].

Presse Med 2018 Nov - Dec;47(11-12 Pt 1):1035-1037. Epub 2018 Oct 29.

CHU Ibn Rochd, service de dermatologie vénérologie, Casablanca, Maroc.

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https://linkinghub.elsevier.com/retrieve/pii/S07554982183036
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http://dx.doi.org/10.1016/j.lpm.2017.11.025DOI Listing
December 2018
7 Reads

Dermatitis herpetiformis in an African woman.

Pan Afr Med J 2018 12;30:119. Epub 2018 Jun 12.

Dermatology and Venereology Clinic, Adult Hospital of University Teaching Hospital, Lusaka, Zambia.

Dermatitis herpetiformis (DH) is an autoimmune blistering disease of the skin. It is a result of hypersensitivity to dietary gluten. Diagnosis of DH can be challenging in a low prevalence, resource-limited population. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.119.14012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195247PMC
November 2018
4 Reads

[Boston Keratoprosthesis with temporal aponeurosis graft: A solution when there seems to be no more].

J Fr Ophtalmol 2018 Nov 19;41(9):830-835. Epub 2018 Oct 19.

Service d'ophtalmologie II, centre hospitalier national des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France.

Purpose: To report cases of patients with severe bilateral corneal blindness and recurrent refractory perforation to keratoplasty and conventional treatment, for whom Boston keratoprosthesis (KP) was a satisfactory alternative when combined with a temporalis aponeurosis graft.

Description Of Cases: The first patient had progressive Lyell syndrome with spontaneous corneal perforation. The second had a severe graft vs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01815512183029
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http://dx.doi.org/10.1016/j.jfo.2018.01.010DOI Listing
November 2018
13 Reads

Pustular Eruption After Cocaine Use: Challenge.

Am J Dermatopathol 2018 Nov;40(11):e143

Department of Dermatology, Boston University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1097/DAD.0000000000000990DOI Listing
November 2018
2 Reads

Pustular Eruption After Cocaine Use: Answer.

Am J Dermatopathol 2018 Nov;40(11):859-860

Department of Dermatology, Boston University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1097/DAD.0000000000000989DOI Listing
November 2018
1 Read

In utero development of epidermolysis bullosa acquisita.

Pediatr Dermatol 2019 Jan 18;36(1):e46-e47. Epub 2018 Oct 18.

Department of Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee.

We report the case of an infant born with perioral vesicles that rapidly spread to involve his mouth and the majority of his body. Histopathology, immunofluorescence, and enzyme-linked immunohistochemistry assays confirmed a diagnosis of epidermolysis bullosa acquisita (EBA). His mother had no history of EBA, and serum indirect immunofluorescence was negative. Read More

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http://doi.wiley.com/10.1111/pde.13704
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http://dx.doi.org/10.1111/pde.13704DOI Listing
January 2019
6 Reads

Toxic epidermal necrolysis: the red eye and red herrings in casualty.

BMJ Case Rep 2018 Oct 12;2018. Epub 2018 Oct 12.

Department of Ophthalmology, Queen Elizabeth Hospital Birmingham, Birmingham, Birmingham, UK.

A 38-year-old woman presented to casualty with bilateral red eyes associated with a recent upper respiratory tract infection. This was initially diagnosed as conjunctivitis, however systemic review revealed an erythematous facial and skin rash, mildly swollen lips and mild swallowing difficulties. The patient was referred for an urgent medical assessment, by which time she was found to have erythema affecting 54% of her body surface area and diagnosed with suspected toxic epidermal necrolysis (TEN). Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22586
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http://dx.doi.org/10.1136/bcr-2018-225861DOI Listing
October 2018
12 Reads

Co-localization of immunobullous diseases at sites of dermatophytoses: Koebnerisation or a coincidence?

Indian J Dermatol Venereol Leprol 2018 Nov-Dec;84(6):712-717

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_311_17DOI Listing
January 2019
1.325 Impact Factor

Linear IgA bullous dermatosis associated with ulcerative proctitis: treatment challenge.

Dermatol Online J 2018 Jul 15;24(7). Epub 2018 Jul 15.

Naval Medical Center, San Diego, California.

Linear IgA bullous dermatosis is a rare bullous disease in children and adults that can be associated with autoimmune conditions, malignancies, infections, or medication exposure. The definitive diagnosis relies on the biopsy. A 58-year-old man presented to our clinic with a pruritic vesicular and bullous eruption. Read More

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July 2018
3 Reads

Imatinib-induced IgA Pemphigus: Subcorneal Pustular Dermatosis Type.

Indian Dermatol Online J 2018 Sep-Oct;9(5):331-333

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.

Imatinib mesylate, a tyrosine kinase inhibitor, is commonly used in the treatment of chronic myeloid leukemia. IgA pemphigus is a rare bullous dermatosis caused by IgA autoantibodies. Clinical manifestations include localized or generalized itchy blisters and pustules. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_331_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137662PMC
September 2018
9 Reads

Letter to the Editor Regarding "Endovascular Patch Embolization for Blood Blister-Like Aneurysms in Dorsal Segment of Internal Carotid Artery".

World Neurosurg 2018 10;118:379

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2018.05.059DOI Listing
October 2018

Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues.

Dev Cell 2018 10 20;47(2):161-174.e4. Epub 2018 Sep 20.

Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10-12, Barcelona 08028, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, Barcelona 08010, Spain. Electronic address:

Most sporadic carcinomas with high metastatic activity show an increased rate of changes in chromosome structure and number, known as chromosomal instability (CIN). However, the role of CIN in driving invasiveness remains unclear. Using an epithelial model in Drosophila, we present evidence that CIN promotes a rapid and general invasive behavior. Read More

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http://dx.doi.org/10.1016/j.devcel.2018.08.021DOI Listing
October 2018
3 Reads

Coeliac disease and dermatitis herpetiformis - Authors' reply.

Lancet 2018 09;392(10151):917

Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)31894-4DOI Listing
September 2018
10 Reads

Coeliac disease and dermatitis herpetiformis.

Lancet 2018 09;392(10151):916

Department of Internal Medicine, Tenon Hospital (AP-HP), Paris 75020, France. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)31503-4DOI Listing
September 2018
2 Reads

Coeliac disease and dermatitis herpetiformis.

Lancet 2018 09;392(10151):916-917

Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1016/S0140-6736(18)31486-7DOI Listing
September 2018
3 Reads

Efficacy and adverse reactions of methotrexate in the treatment of ocular cicatricial pemphigoid: A case series study.

Medicine (Baltimore) 2018 Sep;97(38):e12338

Department of Ophthalmology, The Affiliated Guangren Hospital of Xi'an Jiaotong University.

The application of methotrexate (MTX) in the treatment of autoimmune diseases has been gradually increasing, but reports of MTX treatment for advanced ocular cicatricial pemphigoid (OCP) are extremely rare. This study investigated the efficacy and adverse reactions of low-dose MTX in patients with OCP.This was a retrospective, noncontrolled, case series study. Read More

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http://dx.doi.org/10.1097/MD.0000000000012338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160102PMC
September 2018
4 Reads

Linear IgA bullous dermatosis presenting as chronic prurigo: unveiling of the diagnosis by serrated pattern analysis.

Int J Dermatol 2018 11 19;57(11):e147-e149. Epub 2018 Sep 19.

Department of Dermatology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576104, India.

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http://dx.doi.org/10.1111/ijd.14253DOI Listing
November 2018
2 Reads

Feline Pemphigus Foliaceus.

Authors:
Diane E Preziosi

Vet Clin North Am Small Anim Pract 2019 Jan 15;49(1):95-104. Epub 2018 Sep 15.

Veterinary Specialists of Alaska, 3330 Fairbanks Street, Anchorage, AK 99503, USA. Electronic address:

Feline pemphigus foliaceus is an uncommon skin disorder in cats but still the most common autoimmune skin disorder seen in this species. It is a crusting dermatosis involving the ears, head, paws, and ungual folds primarily. Although cytology is helpful in supporting a diagnosis, biopsy of pustules or crusts for histopathology is required for a definitive diagnosis. Read More

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http://dx.doi.org/10.1016/j.cvsm.2018.08.009DOI Listing
January 2019
8 Reads

Severe hand-foot skin reaction and erythema multiforme-like lesions due to sorafenib.

Postgrad Med J 2018 Sep 17;94(1115):535-536. Epub 2018 Sep 17.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

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http://dx.doi.org/10.1136/postgradmedj-2018-136027DOI Listing
September 2018
1 Read

Ocular cicatricial pemphigoid.

Curr Opin Ophthalmol 2018 Nov;29(6):543-551

Francis I. Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, California, USA.

Purpose Of Review: This review offers recommendations for monitoring disease status in ocular cicatricial pemphigoid as well therapeutic options including local and systemic therapies.

Recent Findings: A negative biopsy on direct immunofluorescence does not preclude a diagnosis of OCP. If a patient's cicatrization is active and/or progressive, systemic immunosuppression should be commenced. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000517DOI Listing
November 2018
3 Reads

Two Cases of Severe Erosive Pustular Dermatosis Mimicking Infection.

Wounds 2018 Aug;30(8):E84-E86

Brigham and Women's Hospital, Boston, MA.

Introduction: Erosive pustular dermatosis of the scalp (EPDS) is a noninfectious inflammatory disorder characterized by pustules, erosions, ulcerations, and crusted erythematous plaques that is often associated with mechanical or chemical trauma. While its appearance may mimic infection, its etiology is thought to have an autoimmune component based on responsiveness to immunomodulators.

Case Report: Herein, the authors present 2 cases of EPDS that were initially treated as primary infections. Read More

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August 2018
4 Reads

A Distinct Clinicopathological Presentation of Cutaneous Dermatophytosis Mimicking Autoimmune Blistering Disorder.

Indian J Dermatol 2018 Sep-Oct;63(5):412-414

Department of Dermatology, GCS Medical College Hospital and Research Institute, Ahmedabad, Gujarat, India.

Infectious diseases can clinically present as vesiculobullous disorders. Direct immunofluorescence (DIF) study of skin biopsy helps distinguish true autoimmune blistering disorders from other conditions. In many situations, even DIF findings in infections disorders imitate autoimmune process. Read More

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http://dx.doi.org/10.4103/ijd.IJD_143_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124232PMC
September 2018
6 Reads

Atypical case of mucous membrane pemphigoid in a 26-year-old man.

BMJ Case Rep 2018 Sep 12;2018. Epub 2018 Sep 12.

Department of Ophthalmology, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA.

A 26-year-old Caucasian man with no previous history of chemical injury presenting with an inability to open his right eye was investigated for mucous membrane pemphigoid and treated. Examination was notable for symblepharon of the right eye and impetigo-like lesions on the face and neck. A biopsy with immunohistochemical analysis was significant for linear deposits of C3 and immunoglobulin G at the level of the epithelial basement membrane, confirming the diagnosis of mucous membrane pemphigoid. Read More

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http://dx.doi.org/10.1136/bcr-2018-225872DOI Listing
September 2018
3 Reads

Prolonging culture of primary human keratinocytes isolated from suction blisters with the Rho kinase inhibitor Y-27632.

PLoS One 2018 12;13(9):e0198862. Epub 2018 Sep 12.

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, United States of America.

Keratinocytes are the most abundant cell type in the epidermis. They prevent desiccation and provide immunological and barrier defense against potential pathogens such as Staphylococcus aureus and Candida albicans. The study of this first line of immune defense may be hindered by invasive isolation methods and/or improper culture conditions to support stem cell maintenance and other potential mechanisms contributing to long-term subcultivation in vitro. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198862PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135349PMC
February 2019
6 Reads

The influence of acute kidney injury on the outcome of Stevens-Johnson syndrome and toxic epidermal necrolysis: The prognostic value of KDIGO staging.

PLoS One 2018 7;13(9):e0203642. Epub 2018 Sep 7.

Kidney Research Center, Department of Nephrology, Change Gung Memorial Hospital, Linkou branch, Taoyuan, Taiwan.

Background: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome are severe drug-induced cutaneous adverse reactions with high mortality. Acute kidney injury (AKI) was a common complication in an SJS/TEN group and noted as an independent risk factor for mortality in patients with SJS/TEN. To determine whether AKI staging can predict the outcome of patients with SJS/TEN, we compared the discriminative power of an AKI KDIGO staging system with that of SCROTEN, APACHE II, APACHE III, and SOFA. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203642PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128626PMC
February 2019
7 Reads
3.234 Impact Factor