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    32429 results match your criteria Subcorneal Pustular Dermatosis

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    Subcorneal pustular dermatosis and episcleritis associated with poorly controlled ulcerative colitis.
    BMJ Case Rep 2017 Jan 30;2017. Epub 2017 Jan 30.
    Department of Dermatology, Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA.
    A man aged 56 years with a history of ulcerative colitis (UC) status postsubtotal colectomy was hospitalised with fevers, dry cough, eye redness and a new bloody, mucoid rectal discharge. 2 months prior to admission, the dermatologist had started him on dapsone for subcorneal pustular dermatosis but did not recognise that he had recently self-discontinued mesalamine enemas, inducing a flare of his UC. After a thorough inpatient evaluation, including flexible sigmoidoscopy, active UC involving the rectal stump was determined to be driving his dermatological and ophthalmological findings. Read More

    Bullous, pseudobullous, & pustular dermatoses.
    Semin Diagn Pathol 2016 Dec 14. Epub 2016 Dec 14.
    Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, United States. Electronic address:
    Several dermatoses are typified by the formation of spaces (blisters; bullae) within or beneath the epidermis. These may be acellular or filled with particular species of inflammatory cells. Etiological categories include infectious, immune-mediated, genetic, drug-related, and idiopathic lesions. Read More

    Can immunohistochemistry replace immunofluorescence in diagnosis of skin bullous diseases?
    APMIS 2017 Feb 3;125(2):114-121. Epub 2017 Jan 3.
    Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt.
    Autoimmune bullous diseases are distressing and sometimes risky bullous dermatoses characterized by the presence of antibodies focused against disease-specific target antigens. Recognition of these antibodies using immunofluorescence is used to be the only sure diagnostic method after reviewing the routine histopathological section. Because of many causes that make the using of immunofluorescence difficult, we tried to evaluate the role of immunohistochemistry in diagnosis of these bullous skin diseases; 40 pemphigus cases (30 pemphigus vulgaris and 10 pemphigus foliaceus) and 37 non-pemphigus cases (35 vesiculobullous skin diseases and 2 normal skin). Read More

    Bullous Systemic Lupus Erythematosus and Lupus Nephritis in a Young Girl.
    Oman Med J 2016 Nov;31(6):453-455
    Division of Pediatric Nephrology, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences Isfahan, Iran.
    Bullous systemic lupus erythematosus (BSLE) is an autoimmune blistering disease occurring in patients with systemic lupus erythematosus (SLE). It is a rare disease, especially in children. A 14-year-old girl initially presented with fatigue, generalized vesiculobullous skin lesions, and ulcers over the hard palate and oral mucosa. Read More

    Pseudo-Bullous Dermatosis Induced by Topical Anesthetic Agent-Clues to This Localized Toxic Reaction.
    Am J Dermatopathol 2017 Feb;39(2):e19-e22
    *Department of Otolaryngology, Head and Neck Surgery, OhioHealth Doctors Hospital, Columbus, OH; †Division of Dermatology, Baylor University Medical Center, Dallas, TX; ‡Department of Dermatology, Walter Reed National Military Medical Center, Bethesda, MD; and §Ackerman Academy of Dermatopathology, New York, NY.
    Eutectic mixture of 2.5% lidocaine and 2.5% prilocaine (EMLA AstraZeneca, DE) is a widely used topical anesthetic cream for preprocedural cutaneous analgesia. Read More

    Safety and Wound Outcomes Following Genetically Corrected Autologous Epidermal Grafts in Patients With Recessive Dystrophic Epidermolysis Bullosa.
    JAMA 2016 Nov;316(17):1808-1817
    Department of Dermatology, School of Medicine, Stanford University, Stanford, California5Veterans Affairs Medical Center, Palo Alto, California.
    Importance: Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating, often fatal, inherited blistering disorder caused by mutations in the COL7A1 gene encoding type VII collagen. Support and palliation are the only current therapies.

    Objective: To evaluate the safety and wound outcomes following genetically corrected autologous epidermal grafts in patients with RDEB. Read More

    Blaptica dubia as sentinels for exposure to chemical warfare agents - a pilot study.
    Toxicol Lett 2016 Nov 14;262:12-16. Epub 2016 Sep 14.
    Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
    The increased interest of terrorist groups in toxic chemicals and chemical warfare agents presents a continuing threat to our societies. Early warning and detection is a key component for effective countermeasures against such deadly agents. Presently available and near term solutions have a number of major drawbacks, e. Read More

    Bullous Pemphigoid: Validation of the National Patient Register in Two Counties in Sweden, 2001 to 2012.
    Acta Derm Venereol 2017 Jan;96(7):32-35
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Bullous pemphigoid (BP) is the most common autoimmune blistering disease. Since 2001, data from all specialized outpatient and inpatient care institutions in Sweden, have been registered with the National Patient Register (NPR), based on a unique personal identification number. Previous validations of the register have shown high accuracy for various non-dermatological autoimmune diseases. Read More

    Ocular manifestations of Stevens-Johnson syndrome and their management.
    Curr Opin Ophthalmol 2016 Nov;27(6):522-529
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
    Purpose Of Review: Recent advances and outcomes data in the management of Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) demonstrate the need for a universal standard of care for patients admitted with the disease.

    Recent Findings: Amniotic membrane transplantation, aggressive topical corticosteroids, and lubrication in the acute stage are necessary to prevent or mitigate long-term ocular sequelae. If chronic ocular disease does occur, several interventions can be employed to prevent progressive vision loss and discomfort. Read More

    Management of patients with ocular manifestations in vesiculobullous disorders affecting the mouth.
    Oral Dis 2016 Oct 7. Epub 2016 Oct 7.
    Department of Ophthalmology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark.
    Pemphigoid and pemphigus diseases as well as Stevens-Johnson syndrome present as vesiculobullous disorders of the skin and may additionally involve both the oral cavity and the ocular surface. Ocular involvement ranges from mild irritation and dry eye disease to chronic conjunctivitis, symblepharon, eyelid malposition, ocular surface scarring and severe visual loss. In addition to diagnostic assessments, ophthalmologists must treat the dry eye and meibomian gland dysfunction components of these diseases using a stepladder approach, including eyelid hygiene and lubricants. Read More

    Histopathology and treatment of a huge overhanging filtering bleb.
    BMC Ophthalmol 2016 Oct 6;16(1):175. Epub 2016 Oct 6.
    Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, People's Republic of China.
    Background: The giant filtering bleb encroaching onto the corneal surface is a rare occurrence in our and other's clinical experience (Kapoor and Syed, Int. Ophthalmol 31(5):403-404, 2011), even in patients having had a trabeculectomy with mitomycin C, and how it developed is debated. In this paper, we report a patient who developed a huge overhanging filtering bleb after trabeculectomy, and present our intraoperative photographs, histopathology and immunohistochemistry results. Read More

    Levofloxacin Induced Toxic Epidermal Necrolysis: Successful Therapy with Omalizumab (Anti-IgE) and Pulse Prednisolone.
    Am J Case Rep 2016 Sep 16;17:666-71. Epub 2016 Sep 16.
    Department of Infectious Diseases, Akdeniz University, Faculty of Medicine, Antalya, Turkey.
    BACKGROUND Toxic epidermal necrolysis (TEN) is characterized by widespread erythematous and bullous lesions on the skin. Nowadays, considerable progress has been made in the understanding of its pathogenesis. Immunologically it is similar to graft-versus-host disease. Read More

    Bullous pemphigoid and its association with neurological diseases: a systematic review and meta-analysis.
    J Eur Acad Dermatol Venereol 2016 Dec 7;30(12):2007-2015. Epub 2016 Sep 7.
    Department of Dermatology, Rutgers New Jersey Medical School, Newark, NJ, USA.
    Bullous pemphigoid (BP) is a chronic, autoimmune vesiculobullous disease that frequently occurs in the elderly population. Previous epidemiological studies have suggested an association between BP and neurological diseases; some studies, however, showed conflicting results. This study aimed to investigate if patients with BP have significantly higher risks for neurological disorders, compared to controls. Read More

    Conjunctival cicatrizing disease presenting with lacrimal obstruction.
    Orbit 2016 Dec 25;35(6):321-323. Epub 2016 Aug 25.
    a Orbital Plastic and Lacrimal Clinic , Royal Victorian Eye and Ear Hospital , Melbourne , Australia.
    Patients with conjunctival cicatrizing disease may develop lacrimal obstruction. Little is published on lacrimal obstruction as the presenting feature of otherwise asymptomatic cicatrizing conjunctival disease. The records of all patients presenting between 1994 and 2015 with lacrimal obstruction found to have cicatrizing conjunctival disease were reviewed. Read More

    Leg amputation and dystrophic epidermolysis bullosa: A case report with 15 years of follow-up.
    J Rehabil Med 2016 Oct;48(9):833-835
    Médecine Physique et de Réadaptation, University hospital, FR-59000 Lille, France.
    Objective: Dystrophic epidermolysis bullosa is a rare disease characterized by widespread blistering of the skin and mucous membranes, which may ultimately prompt limb amputation. In this context, the outcome of fitting a prosthesis to a chronically wounded stump is not well known. Our patient's experience (with 15 years of follow-up) should contribute to better knowledge of this topic. Read More

    Complete remission of skin lesions in a patient with subcorneal pustular dermatosis (Sneddon-Wilkinson disease) treated with antimyeloma therapy: association with disappearance of M-protein.
    Br J Dermatol 2016 Aug 12. Epub 2016 Aug 12.
    Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.
    Subcorneal pustular dermatosis (SPD), or Sneddon-Wilkinson disease, is a rare pustular skin disease that follows a chronic relapsing course. A well-known association exists between SPD and IgA monoclonal gammopathy of undetermined significance (MGUS), which exists in up to 40% of cases. SPD has also been observed in patients with IgA myeloma. Read More

    Morphologic criteria of vesiculobullous skin disorders by in vivo reflectance confocal microscopy.
    J Dtsch Dermatol Ges 2016 Aug;14(8):797-805
    Department of Dermatology, Venereology, and Allergology, University Medical Center, Heidelberg, Germany.
    Background And Objectives: Reflectance confocal microscopy (RCM) may be a useful method for accurate, rapid, and noninvasive bedside diagnosis of vesiculobullous skin diseases (VSD). The main outcome measure of this study was a descriptive statistical analysis of RCM features associated with selected group of VSD.

    Patients And Methods: Single-center, observational study at a university-based dermatology department. Read More

    A case of pulmonary placental transmogrification.
    Asian Cardiovasc Thorac Ann 2016 Oct 28;24(8):811-813. Epub 2016 Jul 28.
    Department of Cardiothoracic Surgery, Guy's and St. Thomas' Hospital, London, UK.
    Pulmonary placental transmogrification is a rare lung lesion that microscopically resembles placenta with cystic spaces filled with papillary structures. Considered a histological variant of bullous emphysema, only 30 reported cases have been published in the world's literature. We report a rare case of pulmonary placental transmogrification in a 72-year-old man, in whom the clinical presentation of the disease mimicked lung carcinoma. Read More

    A vesicular (blistering) skin condition in a dog following putative contact exposure to Plumbago auriculata.
    Aust Vet J 2016 Aug;94(8):290-2
    Oak Flats Veterinary Clinic, 58A Central Avenue, Oak Flats, New South Wales 2529, Australia.
    Case Report: A 2-year-old male Airedale Terrier was presented with an acute and painful, predominantly ventral, vesicular skin eruption following putative dermal contact with Plumbago auriculata (Sky Flower, Leadwort). Prompt dermal decontamination and supportive therapy brought about a rapid recovery in the patient.

    Conclusion: Contact with botanical triggers is an important consideration for causes of acute vesicular skin conditions in dogs. Read More

    UVA1 phototherapy in the treatment of palmoplantar pustulosis: a pilot prospective study.
    Lasers Med Sci 2016 Nov 20;31(8):1641-1643. Epub 2016 Jul 20.
    Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University, Shanghai, China.
    Palmoplantar pustulosis (PPP) is recalcitrant to traditional topical and systemic therapies. Ultraviolet A1 (UVA1) phototherapy, a new therapeutic approach, has recently been shown good efficacy in the treatment of PPP. The purpose of this study was to evaluate the efficacy and safety of UVA1 therapy for the treatment of PPP. Read More

    Recurrent corneal melting in the paraneoplastic pemphigus associated with Castleman's disease.
    BMC Ophthalmol 2016 Jul 12;16:106. Epub 2016 Jul 12.
    Department of Ophthalmology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, China.
    Background: The ocular presentation of Castleman's disease (CD)-associated paraneoplastic pemphigus (PNP) has rarely been reported. In this report, we describe a young patient with CD-associated PNP who had recurrent corneal ulceration in addition to cicatrizing conjunctivitis.

    Case Presentation: We describe a case of 23-year-old male with mucocutaneous erosion and conjunctival injection and erosion who was found to have PNP. Read More

    A review of toxic epidermal necrolysis management in Japan.
    Allergol Int 2017 Jan 8;66(1):36-41. Epub 2016 Jul 8.
    Department of Dermatology, Nippon Medical School, Tokyo, Japan.
    Toxic epidermal necrolysis (TEN) is a severe adverse drug reaction characterized by necrosis of the epidermis. Its incidence is approximately 1 per million a year and average mortality rate is high at 25-50%. TEN has a flu-like prodrome, followed by atypical, targetoid erythematous or purpuric macules on the skin. Read More

    Non-infectious environmental antigens as a trigger for the initiation of an autoimmune skin disease.
    Autoimmun Rev 2016 Sep 8;15(9):923-30. Epub 2016 Jul 8.
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
    Pemphigus represents a group of organ specific autoimmune blistering disorders of the skin mediated by pathogenic autoantibodies with well-defined antigenic targets. While most of these diseases are sporadic, endemic forms of disease do exist. The endemic form of pemphigus foliaceus (also known as fogo selvagem, FS) exhibits epidemiological features that suggest exposure to hematophagous insect bites are a possible precipitating factor of this autoimmune disease, and provides a unique opportunity to study how environmental factors contribute to autoimmune disease development. Read More

    Evaluation of exposure of pemphigus vulgaris patients to Mycobacterium tuberculosis and Aspergillus fumigatus.
    Eur J Clin Microbiol Infect Dis 2016 Nov 11;35(11):1749-1752. Epub 2016 Jul 11.
    Department of Botany and Microbiology, Faculty of Science, Cairo University, Cairo, Egypt.
    The purpose of this study was to screen pemphigus vulgaris (PV) (autoimmune bullous skin disease) for the presence of immunoglobulin G against Mycobacterium tuberculosis and Aspergillus fumigatus. The sera of 60 PV patients and 28 controls were screened for the presence of immunoglobulin G against M. tuberculosis and A. Read More

    [An unusual bodily injury].
    Arch Kriminol 2016 May-Jun;237(5-6):212-9
    In most cases, bodily harm results from the use of sharp objects or blunt force. This paper deals with a 42-year-old pharmacist who was known to the police and the courts because of several previous convictions for bodily injury. The man had visited a pub just before it closed and was therefore not served any drinks. Read More

    Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease.
    Science 2016 Jul 30;353(6295):179-84. Epub 2016 Jun 30.
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA.
    Ideally, therapy for autoimmune diseases should eliminate pathogenic autoimmune cells while sparing protective immunity, but feasible strategies for such an approach have been elusive. Here, we show that in the antibody-mediated autoimmune disease pemphigus vulgaris (PV), autoantigen-based chimeric immunoreceptors can direct T cells to kill autoreactive B lymphocytes through the specificity of the B cell receptor (BCR). We engineered human T cells to express a chimeric autoantibody receptor (CAAR), consisting of the PV autoantigen, desmoglein (Dsg) 3, fused to CD137-CD3ζ signaling domains. Read More

    Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress.
    Am J Clin Dermatol 2016 Dec;17(6):653-671
    Department of Dermatology, Veterans Affairs Medical Center Brooklyn and SUNY Downstate, 800 Poly Place, Brooklyn, NY, 11209, USA.
    Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare, benign yet relapsing pustular dermatosis. Its incidence and prevalence have not been well studied. It characteristically presents as hypopyon pustules on the trunk and intertriginous areas of the body. Read More

    Rev Enferm 2016 Apr;39(4):36-40
    Epidermolysis bullosa is a genetic disease characterized by an alteration in the proteins involved in the binding of the dermis to the epidermis. It can also affect the mucous, causing inner injuries. It is classified into three main types: simple, junctional and dystrophic, and, depending on its inheritance, can be dominant and recessive. Read More

    [Localized bullous pemphigoid triggered by erysipelas].
    Hautarzt 2016 Oct;67(10):829-832
    Klinik für Dermatologie, Venerologie und Allergologie, Ruhr-Universität Bochum, Venenzentrum der dermatologischen und gefäßchirurgischen Kliniken, Gudrunstr. 56, 44791, Bochum, Deutschland.
    Localized bullous pemphigoid is a seldom subtype of bullous pemphigoid. We report the case of a 63-year-old man who developed tense bullae on an erythematous area on the left calf after two episodes of erysipelas. Using histological and direct immunofluorescence studies localized bullous pemphigoid provoked by erysipelas was diagnosed. Read More

    Painful Oral Ulcers With Lymphadenopathy and Respiratory Symptoms: Challenge.
    Am J Dermatopathol 2016 Jul;38(7):533-5
    Departments of *Pathology, and †Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH; ‡Department of Oral Pathology, The Ohio State University School of Dentistry, Columbus, OH; and §Division of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH.

    [Advancement in the diagnosis and management of toxic epidermal necrolysis].
    Zhonghua Shao Shang Za Zhi 2016 Jun;32(6):341-4
    Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
    Toxic epidermal necrolysis (TEN) is a potentially life-threatening condition usually attributed to severe adverse drug reactions. The evolvement of TEN, including extensive epidermal sloughing, fluid and electrolyte imbalances, hypermetabolism, immune dysfunction, sepsis and organs failure, are very similar to that of extensive burn. There is no unified therapeutic regimen for TEN due to its unclear pathogenesis. Read More

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