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Stomatologiia (Mosk) 2020 ;99(3):18-21

National Medical Research Center of Dentistry and Maxillofacial Surgery, Moscow, Russia.

The article is devoted to the study of immunohistochemical parameters in patients with bullous lesions of the oral mucosa. The biopsy samples of the oral mucosa were studied in 57 patients, including patients with pemphigoid bullosa (38 people) and pemphigus vulgaris (19 people). The results of immunohistochemical studies indicate the cellular mechanisms of damage to the epithelium, in which IL-1, IL-6 and HPV16 are involved. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2020 Jun;22(6):651-655

Department of Pediatrics, Xiangya Hospital of Central South University, Changsha 410008, China.

A girl, aged 12 years, was admitted due to fever and rash for 3 days. The child developed recurrent high fever and rash on both lower extremities 3 days before, and the rash on left lower extremity quickly merged into a patch within 24 hours, with hemorrhage and necrosis in black and purple, large vesicles, and blisters in the center. Laboratory examination showed a reduction in platelet count and significant increases in fibrinogen and D-dimer during the course of the disease. Read More

N Engl J Med 2020 Jun;382(23):2248

Hospital Universitario 12 de Octubre, Madrid, Spain

Ther Adv Respir Dis 2020 Jan-Dec;14:1753466620926800

Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, China.

Increased inflammatory cytokines [such as tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid progression in severe group patients. Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNFα, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. Read More

Hautarzt 2020 Jul;71(7):542-552

Hautklinik, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland.

Background And Objectives: Treatment of severe dermatological autoimmune diseases and toxic epidermal necrolysis (TEN) with high-dose intravenous immunoglobulin (IVIg) is a well-established procedure in dermatology. As treatment with IVIg is usually considered for rare clinical entities or severe cases, the use of immunoglobulin is not generally based on data from randomized controlled trials usually required for evidence-based medicine. Since the indications for the use of IVIg are rare, it is unlikely that such studies will be available in the foreseeable future. Read More

Ned Tijdschr Geneeskd 2020 May 7;164. Epub 2020 May 7.

Elkerliek Ziekenhuis, afd. Longziekten, Helmond.

A 31-year-old non-smoking male patient admitted with and intubated for COVID-19 pneumonia experienced acute chest pain and dyspnea during his recovery period. He was diagnosed with a pneumothorax based on major bullae formation due to COVID-19. The bullae were not visible after extubation and developed rapidly within a few days. Read More

Curr Pharm Biotechnol 2020 May 2. Epub 2020 May 2.

Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona. Italy.

Neutrophilic dermatoses are a heterogeneous group of inflammatory skin disorders characterized by the presence of a sterile, predominantly neutrophilic infiltrate on histopathology. Universally accepted and validated guidelines for the management of neutrophilic dermatoses do not exist, also given the paucity of randomized controlled study and high-quality data. However, the literature on the effective use of biologic therapies is rapidly expanding. Read More

J Am Acad Dermatol 2020 Jul 24;83(1):e61-e63. Epub 2020 Apr 24.

Dermatology Department, Ramon y Cajal University Hospital, Irycis, Madrid, Spain.

Korean J Radiol 2020 05;21(5):627-628

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

J Eur Acad Dermatol Venereol 2020 Jun;34(6):e250-e251

Department of Dermatology, Clinical University Hospital, University of Valencia, Valencia, Spain.

J Am Acad Dermatol 2020 06 10;82(6):e235-e236. Epub 2020 Apr 10.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Waste Manag 2020 Apr 3;107:20-27. Epub 2020 Apr 3.

LUT School of Engineering Science, Department of Separation and Purification Technology, LUT University, 53850 Lappeenranta, Finland. Electronic address:

Pharmaceutical blister packages usually comprise of aluminium and plastic layers. Due to their multi-material structure, the discarded packages are typically landfilled, although when separated, both metallic and polymeric fractions would be recyclable. In the present study, separation of aluminium and polymeric layers of waste pharmaceutical blisters was conducted by exploitation of deep eutectic solvent (DES, lactic acid - choline chloride) and pure lactic acid, both of which are considered green solvents. Read More

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Department of Dermatology, School of Medicine, Ankara Yıldırım Beyazıt University, Ankara.

An 89-year-old woman presented with plaque-like lesions, accompanied with pustules and desquamation on the back and front of the trunk for approximately one year. Long term use of potent topical corticosteroids was ineffective. Because of the chronicity of her condition, the diagnoses of subcorneal dermatosis or subcorneal pustular dermatosis type of IgA pemphigus were considered. Read More

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Department of Dermatology, University of New Mexico, School of Medicine, Albuquerque, NM.

Grover disease (GD) is an acquired, nonfamilial, nonimmune mediated, transient or persistent acantholytic dermatosis. Herein, we present a 72-year-old man who had clinical and histopathologic findings of GD following two weeks of treatment with vemurafenib without MEK inhibitor. The patient was successfully treated with topical emollients and a high-potency corticosteroid. Read More

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Cedars Dermatology, Cedars Sinai Medical Group, CA.

Thiotepa is a common alkylating agent known to precipitate cutaneous reactions consistent with toxic erythema of chemotherapy, including erythema and hyperpigmentation. Herein, we describe an atypical case of malignant intertrigo involving preferential erythema and desquamation not only of skin folds but also of occluded areas after thiotepa-based conditioning. The diagnosis was complicated by concurrent stomatitis and oral petechiae in the setting of autologous stem cell transplant 11 days prior for diffuse large B-cell lymphoma. Read More

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Foundation University Medical College, Islamabad.

Transient acantholytic dermatosis (TAD) is a relatively common entity that has been also noted to occur in patients with cancer. Herein, we describe a case of transient acantholytic dermatosis occurring in a patient with a history of prostate cancer status post radiation, now being treated with combination therapy with pembrolizumab and carboplatin-pemetrexed for advanced lung adenocarcinoma. Our case emphasizes the importance of being cognizant of TAD and its associations, particularly in cancer patients. Read More

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Department of Dermatology, University of Illinois at Chicago, Chicago, IL.

Follicular occlusion triad is a symptom complex of three conditions with a similar pathophysiology including hidradenitis suppurativa (HS), dissecting cellulitis of the scalp, and acne conglobata. Although the exact pathogenesis of the triad is unknown, it appears to be related to follicular occlusion in areas with apocrine glands. Wolf isotopic response refers to the occurrence of a new dermatosis at the site of another, unrelated, previously healed dermatosis. Read More

Rev Med Suisse 2020 Apr;16(688):624-628

Service de dermatologie, CHUV, 1011 Lausanne.

Bullous pemphigoid is the most frequent autoimmune bullous dermatosis. Cases induced by immune checkpoint inhibitors have been described. This antitumor immunotherapy changed the treatment of several malignant tumors, especially melanoma and non-small cell lung-cancer. Read More

Rev Prat 2019 Sep;69(7):e219-e226

Service de dermatologie, CHU de Nantes, Nantes, France.

PLoS One 2020 30;15(3):e0230419. Epub 2020 Mar 30.

Toxicology Unit and Drug Abuse Center, University of Modena and Reggio Emilia, Reggio Emilia, Italy.

Background: The notion that smoking cannabis may damage the respiratory tract has been introduced in recent years but there is still a paucity of studies on this subject. The aim of this study was to investigate the relationship between cannabis smoking, pneumothorax and bullous lung disease in a population of operated patients.

Methods And Findings: We performed a retrospective study on patients operated on for spontaneous pneumothorax. Read More

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Apr;37(4):445-448

Department of Health Management, Henan Provincial People's Hospital (People's Hospital of Zhengzhou University), Zhengzhou, Henan 450003, China.

Objective: To carry out genetic testing and prenatal diagnosis for a family affected with recessive dystrophic epidermolysis bullosa (RDEB).

Methods: All exons of the COL7A1 gene and their flanking regions were subjected to PCR and Sanger sequencing. Suspected variant was validated in family members, based on which prenatal diagnosis was provided. Read More

Korean J Radiol 2020 05 20;21(5):541-544. Epub 2020 Mar 20.

Department of Radiology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The coronavirus disease 2019 (COVID-19) pneumonia is a recent outbreak in mainland China and has rapidly spread to multiple countries worldwide. Pulmonary parenchymal opacities are often observed during chest radiography. Currently, few cases have reported the complications of severe COVID-19 pneumonia. Read More

Clin Dermatol 2020 Jan - Feb;38(1):19-34. Epub 2019 Oct 24.

Department of Dermatology and Venereology, Trakia University, Stara Zagora, Bulgaria.

Various infections and autoimmune and reactive skin conditions can present with blisters of varying sizes. Some of these disorders are seen in everyday practice, whereas others are rarely encountered. In many cases, the clinical picture is so typical that the diagnosis is easy and obvious; nevertheless, the significant clinical overlap between many of these diseases can cause frustration in both unexperienced and expert clinicians. Read More

Medicine (Baltimore) 2020 Mar;99(12):e19431

Department of Respiratory.

Rationale: Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are extremely rare but potentially life-threatening disorders. We presented 3 fatal pediatric SJS/TEN cases.

Patient Concerns: Our patients had some severe complications such as septic shock, respiratory failure and obliterans bronchiolitis (BO) etc. Read More

Oncology 2020 17;98(5):318-320. Epub 2020 Mar 17.

Keck-USC Department of Dermatology, Los Angeles, California, USA.

Background: Bullous pemphigoid (BP) is a rare autoimmune blistering condition characterized by antibodies to the structural proteins BP1 and BP2 at the dermal-epidermal junction. The link between BP and malignancy remains unclear. Due to the rarity of the disease, there have been few studies with small sample sizes characterizing the association between BP and malignancy. Read More

Int J Dermatol 2020 05 17;59(5):e135-e136. Epub 2020 Mar 17.

Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.

Ann Allergy Asthma Immunol 2020 06 10;124(6):624-626. Epub 2020 Mar 10.

Department of Otolaryngology, Division of Allergy and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

An Bras Dermatol 2020 Mar - Apr;95(2):266-268. Epub 2020 Feb 20.

Faculdade de Medicina, Centro Universitário Católico Salesiano Auxilium, Unisalesiano, Araçatuba, SP, Brazil.

Spec Care Dentist 2020 May 12;40(3):280-284. Epub 2020 Mar 12.

Division of Dentistry, Hospital das Clinicas, Medical School, University of São Paulo, São Paulo, Brazil.

Pemphigus vulgaris (PV) is a rare and potentially lethal autoimmune disease that affects the skin and mucous membranes. Injuries caused by the disease cause pain, risk of infection, and other complications that result in a high mortality rate. Frequently, management of the PV requires intensive care and a multidisciplinary approach. Read More

Nihon Shokakibyo Gakkai Zasshi 2020 ;117(3):252-260

Department of Gastroenterology, Sanda City Hospital.

A 57-year-old female presented with a chief complaint of odynophagia during medical treatment for systemic lupus erythematosus (SLE). Endoscopy revealed sloughed mucosa along the entire esophageal length, and normal mucosa was easily stripped by withdrawal of the biopsy forceps. Blistering eruptions subsequently appeared on her upper extremities, trunk, and oral cavity. Read More

BMJ 2020 Mar 11;368:m525. Epub 2020 Mar 11.

National Hospital Organization Tokyo Medical Center, Tokyo, Japan.

An Bras Dermatol 2020 Mar - Apr;95(2):255-256. Epub 2020 Jan 31.

Department of Dermatology, Universidade de Santo Amaro, São Paulo, SP, Brazil; Department of Dermatology, Hospital e Maternidade Santa Joana, São Paulo, SP, Brazil.

Pediatr Ann 2020 Mar;49(3):e124-e131

Infestations and arthropod bite reactions in children are common reasons for presentation to pediatric health care providers. Infestations in children include head lice, scabies, and other mites. Fleas and bed bugs are common causes of bite reactions in children, and papular urticaria is a chronic, recurrent eruption resulting from delayed hypersensitivity to a variety of insect bites. Read More

Dermatol Online J 2020 Jan 15;26(1). Epub 2020 Jan 15.

Department of Dermatology, University of Rochester Medical Center, Rochester, NY.

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening, cutaneous reactions often associated with culprit drugs. A growing body of knowledge has deepened our understanding of the pathophysiology and clarified mechanisms such as drug-specific cytotoxicity mediated by T-cells, genetic linkage with HLA and non-HLA genes, TCR restriction, and cytotoxicity mechanisms. Physicians should broadly consider the etiology of SJS/TEN in order to better understand treatment strategies as well as identify which patients may be at risk for developing this condition. Read More

Am Fam Physician 2020 03;101(5):305-306

Yale School of Medicine, New Haven, CT, USA.

Pflege 2020 Apr 12;33(2):75-84. Epub 2020 Feb 12.

Deutsches Kinderschmerzzentrum, Vestische Kinder- und Jugendklinik, Datteln.

Living with bandages: a mixed-methods-study on the view of families of children with epidermolysis bullosa Children with epidermolysis bullosa (EB) often need new bandages regularly due to sore skin and blistering. The question about the experiences of parents and children affected by EB with dressing materials is intended to identify starting points for effective support of families. In the first part of the sequential mixed-methods study, guideline-based interviews were conducted and evaluated with qualitative content analysis. Read More

Dermatol Online J 2019 Dec 15;25(12). Epub 2019 Dec 15.

Department of Dermatology, University of Texas Medical Branch, Galveston, TX.

Lichen sclerosus (LS) is a chronic dermatologic condition characterized by atrophic porcelain-appearing plaques that can cause intense discomfort and eventually lead to destruction of local architecture. Lichen sclerosus most commonly arises in the anogenital area, but up to 20% of cases can present on extragenital skin. Rarely, LS can also present with hemorrhage and bullae; the mechanism by which this occurs is unknown. Read More

Dermatol Online J 2019 Nov 15;25(11). Epub 2019 Nov 15.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA.

Mucous membrane pemphigoid (MMP) with ocular involvement, also referred to as ocular cicatricial pemphigoid, is a rare, autoimmune blistering disease that can have devastating effects for patients. The resulting corneal neovascularization, recurrent corneal abrasions, and ulceration can ultimately result in severe vision loss. We present a 64-year-old man with recalcitrant ocular MMP and consequently advanced corneal involvement that received bilateral keratoprostheses. Read More

Dermatol Online J 2019 Nov 15;25(11). Epub 2019 Nov 15.

Department of Dermatology, University of California San Diego, San Diego, CA.

Bullous pemphigoid (BP) is an autoimmune blistering disorder that predominantly affects the elderly. Treatment regimens typically include topical and systemic immunosuppressive medications. Although effective, systemic corticosteroids are sometimes poorly tolerated in the elderly patient, contributing to the overall morbidity and mortality of BP. Read More

Dermatol Online J 2019 Nov 15;25(11). Epub 2019 Nov 15.

Department of Dermatology, Ataturk Research and Training Hospital, Izmir.

Neonatal sucking blisters result from vigorous sucking on hand or forearm in utero. Clinically, one observes a tense, fluid-filled blister, which when ruptured forms an erosion. We report a female neonate with a sucking blister on the distal dorsal aspect of her left forearm. Read More

Niger J Clin Pract 2020 Feb;23(2):159-164

Akdeniz University, Faculty of Medicine, Department of Dermatology and Venereology, Antalya, Turkey.

Background: There is an increased risk of long-term dental and periodontal disease in autoimmune bullous diseases (AIBD).

Aims: In this cross-sectional study, we aimed to determine whether the oral health-related quality of life status (OHRQoL) was associated with disease severity and activity in patients with AIBD.

Subjects And Methods: 67 patients with AIBD were enrolled in this study. Read More

Indian J Pharmacol 2019 Nov-Dec;51(6):407-409. Epub 2020 Jan 16.

Department of Neurosurgery, All India Institute of Medical Science, Jodhpur, Rajasthan, India.

Mannitol has been the cornerstone of osmotherapy in the treatment of raised intracranial pressure for the past several decades. We discuss here a case of subcutaneous mannitol extravasation, leading to bullous eruptions and swelling in the forearm of a postoperative patient of arteriovenous malformation. We emphasize the importance of careful selection of peripheral intravenous catheter site, especially when infusing hypertonic solutions with propensity for subcutaneous leaks and tissue damage. Read More

BMJ 2020 Feb 6;368:l7007. Epub 2020 Feb 6.

Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine; Institute of Psoriasis, Tongji University School of Medicine, Shanghai, China.

J Korean Med Sci 2020 Feb 3;35(4):e17. Epub 2020 Feb 3.

Department of Neurology, Konkuk University School of Medicine, Seoul, Korea.

Background: Severe and life-threatening drug eruptions include drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). One class of medications that has been highly associated with such drug eruptions is antiepileptic drugs (AEDs). We attempt to investigate drug eruptions associated with AEDs as a class, as well as with individual AEDs, in Korea. Read More

Cas Lek Cesk 2019 ;158(7-8):314

In the department of gerontopsychiatry we can encounter various conditions that complicate basic psychiatric treatment, often because of old age, polymorbidity and fragility of hospitalized patients. Stevens-Johnson Syndrome (SJS) is a rare disease with high mortality. The case report describes the course of the patient's disease, including treatment, interventions and pharmacological considerations with an emphasis on multidisciplinary cooperation. Read More

Turk J Pediatr 2019 ;61(4):538-543

Ophthalmology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.

Kara A, Devrim İ, Çağlar İ, Bayram N, Kundak S, Apa H, Altan EV. Stevens-Johnson syndrome and toxic epidermal necrolysis: a report of six cases. Turk J Pediatr 2019; 61: 538-543. Read More

Immunopharmacol Immunotoxicol 2020 02 27;42(1):56-58. Epub 2020 Jan 27.

Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Am J Trop Med Hyg 2019 09;101(3):476-477

Department of Internal Medicine, São Paulo State University, São Paulo, Brazil.

Med Oral Patol Oral Cir Bucal 2020 Mar 1;25(2):e262-e267. Epub 2020 Mar 1.

Background: Epidermolysis bullosa (EB) comprises a group of hereditary disorders characterized by mechanical fragility of the skin and mucous membranes, with the development of blisters and vesicles in response to minimum tissue friction. Recessive dystrophic epidermolysis bullosa (RDEB) with generalized involvement is the most common subtype in the oral cavity. The present study was carried out to investigate dental implant survival, peri-implant tissue condition, patient satisfaction, and the impact of treatment upon the quality of life of patients with RDEB rehabilitated with implants and full-arch implant-supported prostheses. Read More

Hautarzt 2020 Feb;71(2):85-90

Universitätsklinik für Dermatologie und Allergologie, EB-Haus Austria, Universitätsklinikum der Paracelsus Medizinischen Privatuniversität Salzburg, Müllner Hauptstraße 48, 5020, Salzburg, Österreich.

Background: Use of ex vivo stem cell gene therapy enables the correction of the genetic cause of a monogenetic skin disease.

Objectives: The procedure and choice of gene therapy method in the course of ex vivo gene therapy of the skin are presented.

Materials And Methods: Current gene therapeutic applications focus on the addition or targeted correction of the respective gene within the genome. Read More