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    32792 results match your criteria Subcorneal Pustular Dermatosis

    1 OF 656

    Interruption of Sneddon-Wilkinson Subcorneal Pustulation with Infliximab.
    Case Rep Dermatol 2017 Jan-Apr;9(1):140-144. Epub 2017 Apr 27.
    aDepartment of Dermatology, University Hospital of Zurich, Zurich, Switzerland.
    Subcorneal pustular dermatosis (SCPD, Sneddon-Wilkinson disease) is a rare chronic-relapsing skin disorder that typically manifests as flaccid sterile pustules without systemic symptoms. Although the accumulation of neutrophils is acknowledged to be a hallmark of SCPD, its exact pathomechanism is still not known. Several chemotactic factors have been implicated in neutrophil recruitment and invasion, including the proinflammatory cytokine TNF-α. Read More

    [A particular type of cicatricial Pemphigoid with unique IgA deposit].
    Pan Afr Med J 2017 13;26:136. Epub 2017 Mar 13.
    Université de Sousse, Tunisie.
    Cicatricial Pemphigoid is a subepithelial bullous dermatosis which essentially involves the mucous membranes with cicatricial evolution We report the case of a 66-year old patient hospitalized with erosive gingivitis associated with dysphagia, dyspnea and blurred vision. Dermatologic examination showed erosive lesions involving the palate and the pharynx. Ophthalmologic examination showed symblepharons, ectropion and bilateral cataract. Read More

    A study of clinical, histopathological and direct immunofluorescence diagnosis in pemphigus group Utility of direct immunofluorescence.
    Bratisl Lek Listy 2017 ;118(4):243-249
    Aims: To determine the diagnostic accordance between histopathological and direct immunofluorescence diagnosis of patients with autoimmune vesiculobullous skin diseases.

    Background: The term pemphigus refers to a group of autoimmune blistering diseases mediated by auto-antibodies directed against desmoglein proteins. The differentiation between the various bullous diseases is important for treatment and prognosis. Read More

    Molecular Mechanisms Underlying the Filtration Bleb-Maintaining Effects of Suberoylanilide Hydroxamic Acid (SAHA).
    Invest Ophthalmol Vis Sci 2017 Apr;58(4):2421-2429
    Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
    Purpose: Suberoylanilide hydroxamic acid (SAHA) has been shown to support the maintenance of experimental filtration blebs in animal models. This study was performed to investigate the molecular mechanisms underlying the bleb-maintaining effects of SAHA in modulating wound healing activities of conjunctival fibroblasts.

    Methods: Human conjunctival fibroblasts (HConFs) were pretreated with SAHA before treatment with TGF-β2. Read More

    Fever in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Pediatric Cases: Laboratory Work-up and Antibiotic Therapy.
    Pediatr Infect Dis J 2017 May;36(5):513-515
    From the Department of Dermatology, Dokumentationszentrum schwerer Hautreaktionen (dZh), Medical Center-University of Freiburg, Hauptstrasse 7, 79104 Freiburg, Germany.
    Fever is a symptom that often accompanies skin eruptions, especially in children. It can be a sign of an infectious condition presenting with exanthems or it may precede an exanthematous eruption. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe reactions affecting skin and mucosa with blisters and erosions. Read More

    Quarter-Shifted Microincisional Sutureless Vitrectomy in Patients with a Glaucoma Drainage Implant or Filtering Bleb.
    Yonsei Med J 2017 May;58(3):658-661
    Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea.
    When vitrectomy is performed in eyes that have undergone glaucoma surgery, the site of sclerotomy often overlaps with the previous glaucoma operation site. It can lead to serious complications such as postoperative hypotony, leakage, and/or infection. Our technique involves modification of surgeon's position and two sclerotomy sites 45° away from the original position, with an infusion cannula inserted infranasally to avoid damage to the glaucoma drainage implant or filtering bleb. Read More

    Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris.
    Mediators Inflamm 2017 22;2017:7151285. Epub 2017 Feb 22.
    Laboratory of Immunology, Federal University of Triângulo Mineiro, Uberaba, MG, Brazil.
    Pemphigus vulgaris (PV) is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-3. Despite the variety of findings, the chemokine and cytokine profiles that characterize the immune response in the disease are still poorly explored. Thus, 20 PV patients and 20 controls were grouped according to gender, ethnicity, place of residence, and clinical parameters of the disease. Read More

    Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States.
    J Am Acad Dermatol 2017 May 9;76(5):811-817.e4. Epub 2017 Mar 9.
    Department of Dermatology, Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:
    Background: Little is known about the epidemiology of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in children.

    Objective: We sought to determine the morbidity, mortality, and comorbid health conditions of SJS and TEN in US children.

    Methods: This was a cross-sectional study of the 2009 to 2012 Nationwide Inpatient Sample, which contains a representative 20% sample of all US hospitalizations. Read More

    Human Leukocyte Antigen Class I Genes Associated With Stevens-Johnson Syndrome and Severe Ocular Complications Following Use of Cold Medicine in a Brazilian Population.
    JAMA Ophthalmol 2017 Apr;135(4):355-360
    Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto, Prefectural University of Medicine, Kyoto, Japan.
    Importance: Describing the association with human leukocyte antigen (HLA) alleles could facilitate the understanding of increased risk factors for development of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients with severe ocular complications (SOCs).

    Objective: To investigate the association between HLA class I genes and cold medicine (CM)-associated SJS/TEN with SOCs.

    Design, Setting, And Participants: This case-control study was conducted between February 8, 2013, and August 29, 2014. Read More

    Suction blistering the lesional skin of vitiligo patients reveals useful biomarkers of disease activity.
    J Am Acad Dermatol 2017 May 1;76(5):847-855.e5. Epub 2017 Mar 1.
    Department of Medicine, Division of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts. Electronic address:
    Background: Vitiligo is an autoimmune disease of the skin with limited treatment options; there is an urgent need to identify and validate biomarkers of disease activity to support vitiligo clinical studies.

    Objective: To investigate potential biomarkers of disease activity directly in the skin of vitiligo subjects and healthy subjects.

    Methods: Patient skin was sampled via a modified suction-blister technique, allowing for minimally invasive, objective assessment of cytokines and T-cell infiltrates in the interstitial skin fluid. Read More

    Mimickers of classic acantholytic diseases.
    J Dermatol 2017 Mar;44(3):232-242
    Department of Dermatology and Section of Dermatopathology, Boston University School of Medicine, Boston, Massachusetts, USA.
    Acantholysis is a commonly encountered histological pattern which typically generates a differential of the pemphigus variants, Hailey-Hailey, Darier's and Grover's diseases. In addition to these diseases, the dermatologist and dermatopathologist must be aware of entities that mimic classic acantholytic dermatoses and of rare disease variants, which are characterized by acantholysis. Read More

    Amicrobial pustulosis of the folds: Where have we gone 25years after its original description?
    Ann Dermatol Venereol 2017 Mar 24;144(3):169-175. Epub 2017 Feb 24.
    Clinique dermatologique, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France. Electronic address:
    Background: Twenty-five years ago at the Journées Dermatologiques de Paris, Prof. Béatrice Crickx described a new association, "antimicrobial pustulosis and systemic lupus erythematosus", a condition now known as amicrobial pustulosis of the folds (APF). The aim of this study is to analyse the clinical and laboratory characteristics of APF and to outline the gradual advancement of knowledge regarding this disease. Read More

    Paraneoplastic pemphigus associated with chronic lymphocytic leukemia: A case report.
    Medicine (Baltimore) 2017 Feb;96(8):e6184
    Department of Hematology, The First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing, China.
    Rationale: Paraneoplastic pemphigus (PNP) is an autoimmune syndrome associated with neoplasms. The treatment approach principally includes suppressing the immunity, but its therapeutic effect is not satisfying.

    Patient Concerns: We report a case of paraneoplastic pemphigus linked to chronic lymphocytic leukemia in a 63-year-old man. Read More

    The Inpatient Burden of Autoimmune Blistering Disease in US Children: Analysis of Nationwide Inpatient Sample Data.
    Am J Clin Dermatol 2017 Apr;18(2):287-297
    Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.
    Background: Little is known about the epidemiology of pediatric autoimmune blistering disorders (PAIBD).

    Objective: We sought to determine the inpatient burden and comorbidities of PAIBD.

    Methods: We analyzed data from the Nationwide Inpatient Sample from 2002 to 2012, which contained a representative 20% sample of all US hospitalizations. Read More

    Questioning the specificity and sensitivity of ELISA for bullous pemphigoid diagnosis.
    Cutis 2017 Jan;99(1):E27-E30
    Department of Dermatology, Rutgers-Robert Wood Johnson Medical School, Somerset, New Jersey, USA.
    The reported sensitivity and specificity of enzyme-linked immunosorbent assay (ELISA) for bullous pemphigoid (BP) diagnosis is approximately 87% and 98%, respectively. These statistics suggest that ELISA is a reliable diagnostic test; therefore, the use of ELISA for BP diagnosis has increased. We report the case of a man who was diagnosed with BP and was treated for 3 years based on a positive ELISA for IgG against BP180. Read More

    Challenging Airway Secondary to Purpura Fulminans With Face and Neck Bullae in a Premature Infant: A Case Report.
    A A Case Rep 2017 Feb;8(4):70-71
    From the Departments of Pediatric Anesthesiology and Pediatric Plastic Surgery, Children's Memorial Hermann Hospital, McGovern Medical School, Houston, Texas.
    A former 25-week-old neonate presented at 34 weeks postconceptual age with necrotizing fasciitis and purpura fulminans because of Group B Streptococcus infection. He was septic and coagulopathic when he was intubated, and the endotracheal tube was secured with adhesives. When he subsequently developed large purpuric, bullous lesions on the face and neck, he presented to the operating room for excision and debridement of his facial lesions. Read More

    Autoimmune Disease Manifestations in the Oral Cavity.
    Surg Pathol Clin 2017 Mar 28;10(1):57-88. Epub 2016 Dec 28.
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida, 1395 Center Drive, Gainesville, FL 32610, USA.
    Immune-related disorders of the oral cavity may occur as primary disease process, secondary to systemic disease or neoplasm, or as a reaction to medications and other agents. The entities represented within this group may vary significantly by severity, clinical presentation, microscopic presentation, and special testing results. The selected immune-related conditions of the oral cavity in this article are categorized and presented by their prototypical tissue reaction patterns: vesiculobullous, including acantholytic and subepithelial separation; psoriasiform; spongiotic; and lichenoid reaction patterns. Read More

    Reliability and validity of the Chinese version of the autoimmune bullous disease quality of life (ABQOL) questionnaire.
    Health Qual Life Outcomes 2017 Feb 2;15(1):31. Epub 2017 Feb 2.
    Institute of Dermatology and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
    Background: The autoimmune bullous diseases quality of life (ABQOL) questionnaire was recently developed by an Australian group and has been validated in Australian and North American patient cohorts. It is a 17-item, multidimensional, self-administered English questionnaire. The study aimed to validate the Chinese version of the ABQOL questionnaire and evaluate the reliability in Chinese patients. Read More

    Subcorneal pustular dermatosis and episcleritis associated with poorly controlled ulcerative colitis.
    BMJ Case Rep 2017 Jan 30;2017. Epub 2017 Jan 30.
    Department of Dermatology, Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA.
    A man aged 56 years with a history of ulcerative colitis (UC) status postsubtotal colectomy was hospitalised with fevers, dry cough, eye redness and a new bloody, mucoid rectal discharge. 2 months prior to admission, the dermatologist had started him on dapsone for subcorneal pustular dermatosis but did not recognise that he had recently self-discontinued mesalamine enemas, inducing a flare of his UC. After a thorough inpatient evaluation, including flexible sigmoidoscopy, active UC involving the rectal stump was determined to be driving his dermatological and ophthalmological findings. Read More

    A Review of the Pathogenesis of Toxic Epidermal Necrolysis.
    J Nippon Med Sch 2016 ;83(6):216-222
    Department of Dermatology, Nippon Medical School.
    Toxic epidermal necrolysis (TEN) is a rare skin condition, most often drug-induced, known for its skin detachment and high mortality. In general, acute TEN is considered a T-cell mediated, type IV hypersensitivity disorder. It mostly results from a cumulative effect of risks from the drug structure, drug metabolism, HLA alleles and T cell clonotypes. Read More

    [SEM visualization of corneal epithelium through lanthanoid staining based on Ca/Nd isomorphous substitution in Ca-dependent molecular systems].
    Vestn Oftalmol 2016;132(6):11-19
    Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, 119021, Russian Federation.
    Cumulative biomicroscopic evidence is usually sufficient for the diagnosis of recurrent corneal erosion or bullous keratopathy, however, exploration of the disease pathogenesis requires subcellular-level visualization of corneal structure. In the current study, lanthanoid staining and scanning electron microscopy were employed to visualize quite a number of structures responsible for epithelium organization. In particular, the study proves possible the use of Ca/Nd isomorphous substitution at Ca2+ sites of cytoadherence proteins for visualization of corresponding cellular structures. Read More

    The Leukotriene B4 and its Receptor BLT1 Act as Critical Drivers of Neutrophil Recruitment in Murine Bullous Pemphigoid-Like Epidermolysis Bullosa Acquisita.
    J Invest Dermatol 2017 May 17;137(5):1104-1113. Epub 2017 Jan 17.
    Department of Dermatology, Allergy, and Venereology, University of Lübeck, 23538 Lübeck, Germany. Electronic address:
    Recruitment of neutrophils and eosinophils into the skin is a hallmark of pemphigoid diseases. The molecular cues regulating granulocyte recruitment into the skin and the individual contributions of neutrophils and eosinophils to pemphigoid diseases are, however, poorly understood. The lipid mediator leukotriene B4 (LTB4) is a potent granulocyte chemoattractant and is abundant in the skin blister fluid of bullous pemphigoid (BP) patients, but its pathogenic significance is unknown. Read More

    Bullous, pseudobullous, & pustular dermatoses.
    Semin Diagn Pathol 2017 May 14;34(3):250-260. Epub 2016 Dec 14.
    Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, United States. Electronic address:
    Several dermatoses are typified by the formation of spaces (blisters; bullae) within or beneath the epidermis. These may be acellular or filled with particular species of inflammatory cells. Etiological categories include infectious, immune-mediated, genetic, drug-related, and idiopathic lesions. Read More

    Genome-wide association study using the ethnicity-specific Japonica array: identification of new susceptibility loci for cold medicine-related Stevens-Johnson syndrome with severe ocular complications.
    J Hum Genet 2017 Apr 19;62(4):485-489. Epub 2017 Jan 19.
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
    A genome-wide association study (GWAS) for cold medicine-related Stevens-Johnson syndrome (CM-SJS) with severe ocular complications (SOC) was performed in a Japanese population. A recently developed ethnicity-specific array with genome-wide imputation that was based on the whole-genome sequences of 1070 unrelated Japanese individuals was used. Validation analysis with additional samples from Japanese individuals and replication analysis using samples from Korean individuals identified two new susceptibility loci on chromosomes 15 and 16. Read More

    Long-term follow-up analysis of microsurgical clip ligation and endovascular coil embolization for dorsal wall blister aneurysms of the internal carotid artery.
    J Clin Neurosci 2017 May 11;39:72-77. Epub 2017 Jan 11.
    Goodman Campbell Brain and Spine, Indiana University, Department of Neurological Surgery, Indianapolis, IN, United States. Electronic address:
    Blister aneurysms at non-branching sites of the dorsal internal carotid artery (dICA) are fragile, rare, and often difficult to treat. The purpose of this study is to address the demographics, treatment modalities, and long-term outcome of patients treated for dICA blister aneurysms. A retrospective review of medical records identified all consecutive patients who presented with a blister aneurysm from 2002 to 2011 at our institution. Read More

    Correlation of antimuscarinic acetylcholine receptor antibody titers and antidesmoglein antibody titers with the severity of disease in patients with pemphigus.
    J Am Acad Dermatol 2017 May 11;76(5):895-902. Epub 2017 Jan 11.
    Department of Biochemistry, Jawaharalal Institute of Postgraduate Medical Education and Research, Puducherry, India.
    Background: Acetylcholine receptor (AchR) antibody levels significantly correlate with disease severity at initial pemphigus diagnosis and during follow-up. However, it is not clear if they are just an epiphenomenon or a potential trigger of the known pathogenic process in pemphigus vulgaris.

    Objective: We sought to assess the changes in anti-muscarinic (M3) AchR and anti-desmoglein (Dsg) antibody titers with therapy. Read More

    Salivary Samples for the Diagnosis of Pemphigus vulgaris Using the BIOCHIP Approach: a Pilot Study.
    In Vivo 2017 01;31(1):97-99
    Dermatology Unit, Department of Medicine, University of Padua, Padua, Italy
    Pemphigus vulgaris (PV) is a rare autoimmune intraepithelial blistering skin disease characterized by the presence of circulating autoantibodies against desmoglein 3 (DSG3) and desmoglein 1 (DSG1), resulting in loss of the normal epithelial cell-to-cell adhesion, through a process called acantholysis. In recent years, a BIOCHIP-based indirect immunofluorescence technique for the determination of anti-DSG3 and anti-DSG1 autoantibodies has been described. Even though, the use of saliva anti-DSG3 and anti-DSG1 ELISA for the diagnosis of PV has been already reported, there are no studies concerning the utilization of saliva by the BIOCHIP approach. Read More

    Epidemiology and Molecular Characteristics of Mycoplasma pneumoniae During an Outbreak of M. pneumoniae-associated Stevens-Johnson Syndrome.
    Pediatr Infect Dis J 2017 Jun;36(6):564-571
    From the *Epidemic Intelligence Service, and †Respiratory Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; ‡Department of Pediatrics, Section of Infectious Diseases, University of Colorado School of Medicine, and §Department of Pediatrics, Section of Infectious Diseases, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, Colorado; ¶Behavioral and Clinical Surveillance Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia; ‖Department of Pathology and Laboratory Medicine, Children's Hospital Colorado, Aurora, Colorado; and **Colorado Department of Public Health and Environment, Denver, Colorado.
    Background: An increase in Mycoplasma pneumoniae-associated Stevens-Johnson syndrome (SJS) cases at a Colorado pediatric hospital led to an outbreak investigation. We describe the epidemiologic and molecular characteristics of M. pneumoniae among SJS case-patients and surrounding community members during the outbreak. Read More

    Can immunohistochemistry replace immunofluorescence in diagnosis of skin bullous diseases?
    APMIS 2017 Feb 3;125(2):114-121. Epub 2017 Jan 3.
    Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt.
    Autoimmune bullous diseases are distressing and sometimes risky bullous dermatoses characterized by the presence of antibodies focused against disease-specific target antigens. Recognition of these antibodies using immunofluorescence is used to be the only sure diagnostic method after reviewing the routine histopathological section. Because of many causes that make the using of immunofluorescence difficult, we tried to evaluate the role of immunohistochemistry in diagnosis of these bullous skin diseases; 40 pemphigus cases (30 pemphigus vulgaris and 10 pemphigus foliaceus) and 37 non-pemphigus cases (35 vesiculobullous skin diseases and 2 normal skin). Read More

    Periodontitis in oral pemphigus and pemphigoid: A systematic review of published studies.
    J Am Acad Dermatol 2017 May 28;76(5):975-978.e3. Epub 2016 Dec 28.
    Department of Dermatology, University of Lübeck, Lübeck, Germany. Electronic address:
    Periodontitis and autoimmune bullous diseases, including pemphigus vulgaris and mucous membrane pemphigoid, are immunoinflammatory disorders leading to microbial plaque- and autoantibody-elicited tissue injury of the oral cavity, respectively. Evidence indicates that these autoimmune conditions may represent a risk factor for periodontitis, but no systematic evaluation exists to corroborate this assumption. A systematic literature review of periodontal status in pemphigus and pemphigoid was conducted. Read More

    Prospective studies on the routine use of a novel multivariant enzyme-linked immunosorbent assay for the diagnosis of autoimmune bullous diseases.
    J Am Acad Dermatol 2017 May 28;76(5):889-894.e5. Epub 2016 Dec 28.
    Department of Dermatology, University of Lübeck, Lübeck, Germany; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany. Electronic address:
    Background: Serologic diagnosis of autoimmune blistering disease (AIBD) usually follows a sophisticated multistep algorithm.

    Objective: We sought validation of a multivariant enzyme-linked immunosorbent assay (ELISA) in the routine diagnosis of AIBD.

    Methods: The multivariant ELISA comprising 6 recombinant immunodominant forms of major AIBD target antigens, ie, desmoglein 1, desmoglein 3, envoplakin, BP180, BP230, and type VII collagen was applied in: (1) a cohort of well-characterized AIBD (n = 173) and control sera (n = 130), (2) a prospective multicenter study with 204 sera from patients with newly diagnosed AIBD with positive direct immunofluorescence microscopy, and (3) a prospective monocenter study with 292 consecutive sera from patients with clinical suspicion of AIBD in comparison with the conventional multistep diagnostic algorithm. Read More

    Rituximab Treatment for Recalcitrant Dermatitis Herpetiformis.
    JAMA Dermatol 2017 Mar;153(3):315-318
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia.
    Importance: Dermatitis herpetiformis (DH) is an autoimmune blistering condition seen in the context of celiac disease. While typically managed by gluten-free diet and dapsone, treatment of DH refractory to standard treatments is not well defined.

    Observations: A man in his 80s with DH not controlled by gluten-free diet (with poor adherence), dapsone, and conventional immune-suppressing agents responded to treatment with rituximab according to the lymphoma protocol (4 weekly infusions of 375 mg/m2). Read More

    Bullosis Diabeticorum in a Young Child: Case Report of a Very Rare Entity and a Literature Review.
    Can J Diabetes 2017 Apr 21;41(2):129-131. Epub 2016 Dec 21.
    Department of Pathology, University of Medicine and Pharmacy Tirgu Mures, Tirgu Mures, Romania.
    Bullosis diabeticorum (BD), or diabetic bulla, is 1 of the cutaneous manifestations of diabetes mellitus, reported in 0.5% of people with diabeties in the United States, mostly in adult men who have had long-lasting and uncontrolled diabetes associated with diabetic peripheral neuropathy. However, BD in young children is a mostly unrecognized entity. Read More

    Minimally invasive endoscopic treatment for pediatric combined high grade stenosis as a laryngeal manifestation of epidermolysis bullosa.
    Int J Pediatr Otorhinolaryngol 2017 Jan 23;92:126-129. Epub 2016 Nov 23.
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Szeged, Hungary.
    Epidermolysis bullosa refers to a clinically and genetically heterogeneous group of inherited mucocutaneous diseases. Laryngotracheal lesions are momentous regarding the risk of sudden airway obstruction. The traditional treatment is tracheostomy. Read More

    Interleukin-15 Is Associated with Severity and Mortality in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.
    J Invest Dermatol 2017 May 21;137(5):1065-1073. Epub 2016 Dec 21.
    Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou and Keelung, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China. Electronic address:
    Early diagnosis and prognosis monitoring for Stevens-Johnson syndrome/toxic epidermal necrolysis (TEN) still remain a challenge. This study aims to explore any cytokine/chemokine with prognostic potential in Stevens-Johnson syndrome/TEN. Through screening a panel of 28 serological factors, IL-6, IL-8, IL-15, tumor necrosis factor-α, and granulysin were upregulated in patients with Stevens-Johnson syndrome/TEN and selected for the further validation in total 155 patients with Stevens-Johnson syndrome/TEN, including 77 from Taiwan and 78 from the Registry of Severe Cutaneous Adverse Reactions. Read More

    Specific skin signs as a cutaneous marker of diabetes mellitus and the prediabetic state - a systematic review.
    Dan Med J 2017 Jan;64(1)
    Introduction: Diabetes mellitus and the prediabetic state are associated with a number of skin manifestations. This study is a systematic review of the following manifestations: acanthosis nigricans (AN), skin tags (ST), diabetic dermopathy (DD), rubeosis faciei (RF), pruritus (PR), granuloma annulare (GA), necrobiosis lipoidica (NL), scleroedema diabeticorum (SD) and bullosis diabeticorum (BD). These conditions possibly relate to underlying diabetogenic mechanisms. Read More

    Erythema exsudativum multiforme induced by a taurine-containing energy drink.
    Acta Dermatovenerol Alp Pannonica Adriat 2016 Dec;25(4):83-84
    Department of Nuclear Medicine, University Clinical Center of Kosovo, Prishtina, Kosovo.
    Erythema exsudativum multiforme is an immunologically mediated skin condition caused by viruses, bacteria, food, and drugs. There are different forms, and depending on the severity of the disease there is a major and minor form. Whereas the minor form passes without consequences, the major form and Stevens-Johnson syndrome affect the mucosa and may result in death. Read More

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