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    33500 results match your criteria Subcorneal Pustular Dermatosis

    1 OF 670

    A Case of Ceftriaxone-Induced Acute Generalized Exanthematous Pustulosis/Generalized Pustular Psoriasis Overlap.
    Case Rep Dermatol 2018 Jan-Apr;10(1):69-75. Epub 2018 Mar 27.
    Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, China.
    Acute generalized exanthematous pustulosis, characterized by subcorneal or superficial intraepidermal pustules, is induced by drugs in more than 90% of cases. Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. Generalized pustular psoriasis is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. Read More

    Bullous pemphigoid associated with chronic hepatitis C virus infection in a hepatitis B virus endemic area: A case report.
    Medicine (Baltimore) 2018 Apr;97(15):e0377
    Department of Pathology, Inha University Hospital, Inha University School of Medicine, Incheon, South Korea.
    Introduction: Bullous pemphigoid is a type of acute or chronic autoimmune disease that involves subepidermal skin lesions with bulla formation. Although viral infections, such as, human herpes virus (HHV), human immunodeficiency virus, cytomegalovirus, Epstein-Barr virus, HHV-6, hepatitis B virus (HBV), and hepatitis C virus (HCV), are known factors of bullous pemphigoid, HCV infection has only been rarely associated factor, especially in HBV endemic area. A 78-year-old man was admitted to our hospital due to erythematous bulla of onset 3 months before presentation affecting his entire body. Read More

    Hydroa vacciniforme-like cutaneous T-cell lymphoma in a child: A case report.
    Medicine (Baltimore) 2018 04;97(15):e0319
    Department of Pediatrics, West China Second University Hospital.
    Rationale: Hydroa vacciniforme (HV)-like T-cell lymphoma is a rare malignancy in childhood associated with Epstein-Barr virus infection.

    Patient Concerns: A 6-year old girl presented with complaint of 3-year history of recurrent skin lesions, 3 months of fever accompanied by cough for 8 days.

    Diagnoses: Skin biopsy revealed a HV-like lymphoma presentation and positive signals of EBER were detected by in situ hybridization. Read More

    Subcorneal pustular dermatosis in the pediatric age.
    An Bras Dermatol 2018 Jan-Feb;93(1):116-118
    Department of Dermatology. Hospital do Servidor Público Estadual de São Paulo - São Paulo (SP), Brazil.
    Subcorneal pustular dermatosis is a rare pustular eruption which occurs mainly in middle-aged women and rarely during childhood. We report a case of a 15-year-old female with a 4-year history of pustular lesions on the proximal region of the upper limbs with subsequent impairment of the trunk. Physical examination revealed small pustules distributed on the trunk and proximal region of the limbs. Read More

    Type I Gaucher disease with bullous pemphigoid and Parkinson disease: A case report.
    Medicine (Baltimore) 2018 Mar;97(13):e0188
    Department of Clinical Neurosciences, University Hospital of Geneva.
    Rationale: Gaucher disease (GD) is a rare genetic lysosomal storage disorder inherited in an autosomal recessive pattern. GD is due to the deficiency of a lysosomal enzyme, acid beta-glucosidase (or glucocerebrosidase). Type 1 Gaucher disease (GD1) is characterized by thrombocytopenia, anemia, an enlarged spleen, and liver as well as bone complications (Erlenmeyer flask deformity, osteoporosis, lytic lesions, pathological and vertebral fractures, bone infarcts, and avascular necrosis leading to degenerative arthropathy). Read More

    [Bullous pemphigoid and Parkinson's disease: about a case].
    Pan Afr Med J 2017 4;28:111. Epub 2017 Oct 4.
    Service de Dermatologie, Centre Hospitalier Universitaire Avicenne, Faculté de Médecine et de Pharmacie Mohamed V, Rabat, Maroc.
    Bullous pemphigoid (BP) is an organ-specific autoimmune disease which can be associated with many pathologies including degenerative neurological diseases such as Parkinson's and Alzheimer's disease. Studies have suggested the possibility of cross-immune responses through "epitope spreading". Bullous dermatosis has been reported to be secondary to neurological disease, at intervals ranging from a few months to a maximum of a few years. Read More

    Nursing care of a boy seriously infected with Steven-Johnson syndrome after treatment with azithromycin: A case report and literature review.
    Medicine (Baltimore) 2018 Jan;97(1):e9112
    Department of Children's Critical Care Medicine, Xin-Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Rationale: Stevens-Johnson syndrome (SJS) is an acute blistering disease of the skin and mucous membranes. SJS in children is not common but potentially serious disease. But the epidemiology of SJS in China is not well defined. Read More

    A "late-but-fitter revertant cell" explains the high frequency of revertant mosaicism in epidermolysis bullosa.
    PLoS One 2018 22;13(2):e0192994. Epub 2018 Feb 22.
    University of Groningen, University Medical Center Groningen, Department of Dermatology, Groningen, the Netherlands.
    Revertant mosaicism, or "natural gene therapy", is the phenomenon in which germline mutations are corrected by somatic events. In recent years, revertant mosaicism has been identified in all major types of epidermolysis bullosa, the group of heritable blistering disorders caused by mutations in the genes encoding epidermal adhesion proteins. Moreover, revertant mosaicism appears to be present in all patients with a specific subtype of recessive epidermolysis bullosa. Read More

    Paraneoplastic Pemphigus in a 34-year-old.
    Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.
    New York University Health, New York.
    Paraneoplastic Pemphigus (PNP) is a rare and often fatal autoimmune mucocutaneous blistering disease associated with an underlying malignancy. It is thought to be caused by antibodies to tumor antigenscross-reacting with epithelial antigens, specifically desmosomal and hemidesmosomal antigens. There are at least five clinical morphologic variants of PNP, with the earliest and most consistent finding beingsevere stomatitis. Read More

    Epidermolysis bullosa acquisita.
    Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.
    New York University, New York.
    Epidermolysis bullosa acquisita (EBA) is a rare, acquired subepidermal blistering disease. EBA is characterized by autoantibodies to collagen VII,which serves to link the epidermis to the dermis. The two most common presentations of EBA are classical noninflammatory EBA and bullous pemphigoid-like EBA. Read More

    Rituximab and intravenous immunoglobulin as alternatives to long-term systemic corticosteroids in the treatment of pemphigus: a single center case series of 63 patients.
    Dermatol Online J 2018 Jan 19;23(12). Epub 2018 Jan 19.
    Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.
    Rituximab and intravenous immunoglobulin [IVIg] have recently emerged as effective treatments for pemphigus refractory to corticosteroids [CS]. This case series sought to compare the clinical, serologic,and adverse effects of CS, IVIg, and rituximab in patients with pemphigus. A retrospective review of 63 patients with pemphigus vulgaris (PV), pemphigus foliaceus (PF), or paraneoplastic pemphigus (PNP)was performed. Read More

    Association of pemphigus and systemic corticosteroid use with comorbid health disorders: A case-control study.
    Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.
    Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
    Background: Pemphigus is a group of debilitating autoimmune blistering disorders associated with painful blisters of the skin and/or mucous membranes. Identification and management of the comorbiditiesof pemphigus is critically important to minimize morbidity and decrease mortality.

    Objective: To identify the comorbid health conditions of pemphigus vulgaris. Read More

    Flame figures in linear IgA bullous dermatosis: a novel histopathologic finding.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Beth Israel Deaconess Medical Center, Department of Pathology, Harvard Medical School, Boston, Massachusetts.
    Background: Linear IgA bullous dermatosis (LABD) is an autoimmune subepidermal blistering disease usually with a neutrophil rich inflammatory infiltrate, and characterized by linear IgA deposition at the basement membrane zone (BMZ), and neutrophil predominant dermal inflammation. We report a case of LABD with numerous eosinophils and flame figure formation, a unique histopathologic finding not previously reported. A 69-year-old woman presented with a rapidly progressive, intensely pruritic rash over forearms, breasts, axillae, hips, and thighs. Read More

    Classic form of eosinophilic pustular folliculitis in an immunocompetent girl: rapid and complete resolution after low-dose oral indomethacin treatment.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Department of Dermatology, School of Medicine, University of Patras, Rio-Patras, Greece, Center for Dermatologic Diseases, Limassol, Cyprus.
    Eosinophilic pustular folliculitis (EPF) is a rare noninfectious pruritic dermatosis, first described by Ise and Ofuji in 1965. We report the case of a 15-year oldimmunocompetent girl that presented with a widespread papulopustular eruption four days after her arrival in Japan. The clinical diagnosis of the classicform of EPF was confirmed by histological examination of the lesional skin that revealed an intense, mainly eosinophilic, dermal infiltrate within and aroundpilosebaceous units. Read More

    Pediatric pustular psoriasis responsive to cyclosporine bridged to etanercept: A treatment approach.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    New York Presbyterian/Weill Cornell Medical College, New York.
    Pustular psoriasis occurs rarely in children but can present with acute toxicity requiring inpatient admission. For the best approach, medical providers should have an evidence based and systematic treatment algorithm in their armamentarium. Toillustrate this point, we describe a 13-year-old girl who was admitted with generalized pustular psoriasis and who responded dramatically to "wet wrap" therapy and cyclosporine bridged to etanercept. Read More

    Sublamina densa-type linear IgA bullous dermatosis with IgA autoantibodies specific for type VII collagen: a case report and clinicopathological review of 32 cases.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Department of Dermatology, Division of Medical Sciences, University of Fukui, Fukui, Japan.
    Linear IgA bullous dermatosis (LABD) is a rare autoimmune bullous disorder characterized by linear deposits of IgA at the basement membrane zone(BMZ) and/or by circulating IgA anti-BMZ antibodies. Comparing with other immuno-bullous diseases, LABD represents a heterogeneous disease entitywith diversity of pathogenic IgA autoantibodies to different hemidesmosomal antigens and an association with malignancies and occasional drug use. We herein present an 82-year-old Japanese man with LABD, whose indirect immunofluorescence using 1M NaCl-split skin showed positive staining for IgA at the dermal side alone. Read More

    Neutrophilic dermatoses: a broad spectrum of disease.
    G Ital Dermatol Venereol 2018 Apr 24;153(2):265-272. Epub 2018 Jan 24.
    Unit of Dermatology, Carlo Urbai Hospital, AREA Vasta 2 ASUR Marche, Jesi, Ancona, Italy -
    The neutrophilic dermatoses (NDs) comprise a group of heterogeneous disorders characterized by inflammatory skin lesions that histologically show an intense inflammatory infiltrate composed primarily by neutrophils, with no evidence of infection or vasculitis. Although there are distinct clinical differences in the classical lesions of these disorders, many patients have overlapping features. In this review, we describe the clinical aspects of the main NDs, including: Sweet Syndrome, ND of the dorsal hands, pyoderma gangrenosum, erythema elevatum diutinum, subcorneal pustular dermatosis, neutrophilic eccrine hidradenitis, rheumatoid neutrophilic dermatitis, neutrophilic panniculitis, and aseptic abscesses including their association with underlying diseases and the differential diagnoses. Read More

    Optimizing suction blister epidermal graft technique in the surgical treatment of vitiligo.
    An Bras Dermatol 2017 Nov-Dec;92(6):888-890
    Department of Dermatology at Hospital Santa Casa de Curitiba - Curitiba (PR), Brazil.
    Surgical management of vitiligo is considered an excellent terapeutic option for recalcitrant cases, provided the disease is stable and there is absence of Koebner phenomenom. Among surgical modalities, Suction Blister Epidermal Graft is a low cost and effective option (65 to 100% repigmentation can be achieved in up to 80% of patients). We describe how it can be optimized by using an alternative suction equipment, by customization of graft format and by application of an anesthetic technique that substantially reduces procedure time. Read More

    Lichen planus pemphigoides treated with ustekinumab.
    Cutis 2017 Dec;100(6):415-418
    Advanced Desert Dermatology/Midwestern University, Glendale, Arizona, USA.
    A 71-year-old woman presented with pink to violaceous, flat-topped, polygonal papules on the volar wrists, extensor elbows, and bilateral lower legs of 3 years' duration. She also had erythematous, violaceous, infiltrated plaques with microvesiculation on the bilateral thighs of several months' duration. She reported pruritus, burning, and discomfort. Read More

    Downregulation of interferon-γ-induced protein 10 in the tears of patients with Stevens-Johnson syndrome with severe ocular complications in the chronic stage.
    BMJ Open Ophthalmol 2017 7;1(1):e000073. Epub 2017 Aug 7.
    Departments of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Objectives: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute inflammatory vesiculobullous reactions of the skin and mucosa such as the ocular surface, oral cavity and genitals. Severe ocular complications (SOC) arise in some patients with SJS/TEN diagnosed by dermatologists. To investigate the pathophysiology of ocular surface inflammation in SJS/TEN with SOC in the chronic stage, we examined cytokines in the tears of patients with ocular surface diseases and healthy controls. Read More

    Bullous lung diseases as a risk factor for lung cancer: A case report.
    Vojnosanit Pregl 2016 Dec;73(12):1160-3
    Introduction: A possible association between lung cancer and bullous lung disease has been suggested and recently supported by the results of genetic studies.

    Case Report: A previously healthy 43-year-old man, smoker, was diagnosed with bullous lung disease at the age of 31 years. He was followed up for 12 years when lung cancer (adenocarcinoma) was found at the site. Read More

    The use of suction blisters to measure sunscreen protection against UVR-induced DNA damage.
    J Photochem Photobiol B 2018 Feb 22;179:1-6. Epub 2017 Dec 22.
    Centre de Recherche sur la Peau, Pierre Fabre Dermo-Cosmétique, F-31000 Toulouse, France.
    The formation of DNA photoproducts caused by solar UVR exposure needs to be investigated in-vivo and in particular in order to assess sunscreens' level of protection against solar genotoxicity. The study's purposes were: i) to evaluate if the roof of suction blisters is an appropriate sampling method for measuring photoproducts, and ii) to measure in-vivo sunscreen protection against cyclobutane pyrimidine dimers. Skin areas on the interior forearms of eight healthy volunteers were exposed in-vivo to 2 MED of simulated solar radiation (SSR) and to 15 MED on a sunscreen protected area. Read More

    The importance of direct immunofluorescence in pemphigus herpetiformis diagnosis.
    An Bras Dermatol 2017 ;92(5 Suppl 1):145-147
    Dermatology Outpatient Clinic at Hospital do Açúcar de Alagoas do Centro Universitário Tiradentes, Maceió, Alagoas (AL), Brazil.
    Pemphigus herpetiformis is an autoimmune bullous disease, that combines clinical features of dermatitis herpetiformis and linear IgA bullous dermatosis and immunological characteristics of pemphigus, which makes this disease peculiar and this diagnosis rarely suspected in the first evaluation of the patient. The reported case is of a patient with clinically bullous disease similar to dermatitis herpetiformis, whose multiple biopsies were inconclusive, and only after direct immunofluorescence with a pemphigus pattern (intraepidermal intercellular pattern) the confirmation of the diagnosis was possible. Read More

    Pretibial dystrophic epidermolysis bullosa.
    An Bras Dermatol 2017 ;92(5 Suppl 1):126-128
    Department of Dermatopathology of the Department of Anatomic Pathology, Santa Casa de Misericórdia de São Paulo - São Paulo (SP), Brazil.
    Epidermolysis bullosa is a group of mechano-bullous genetic disorders caused by mutations in the genes encoding structural proteins of the skin. Dystrophic epidermolysis bullosa is caused by mutations in the COL7A1 gene encoding collagen VII, the main constituent of anchoring fibrils. In this group, there are autosomal dominant and recessive inheritances. Read More

    Pemphigus foliaceus with pustular presentation in a patient with psoriasis.
    An Bras Dermatol 2017 ;92(5 Suppl 1):115-117
    Dermatology Department at Hospital Universitário Pedro Ernesto, of the Universidade do Estado do Rio de Janeiro (Hupe-Uerj) - Rio de Janeiro (RJ), Brazil.
    Pemphigus foliaceus is a chronic autoimmune disease of the skin, clinically characterized by scaly and crusty cutaneous erosions involving the seborrheic areas. The patient can eventually become erythrodermic. There are reports of atypical cases of pemphigus foliaceus with pustules and neutrophils, and clinical differentiation from generalized pustular psoriasis of von Zumbusch is difficult. Read More

    Bullous systemic lupus erythematosus in a 10-year-old child.
    An Bras Dermatol 2017 ;92(5 Suppl 1):37-39
    Dr. Günter Hans Department of Dermatology at Hospital Universitário Maria Aparecida Pedrossian, of the Universidade Federal de Mato Grosso do Sul (HUMAP-UFMS) - Campo Grande (MS), Brazil.
    Bullous systemic lupus erythematosus (BSLE) is a rare autoimmune subepidermal blistering disease, with few cases described in childhood. It has different clinical-pathological features. We report a case of BSLE in a 10-year-old child with systemic lupus erythematosus, treated with prednisone and hydroxychloroquine. Read More

    Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient.
    An Bras Dermatol 2017 ;92(5 Suppl 1):34-36
    Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China.
    Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, by contrast, is characterized by two autoantibodies (anti-desmoglein 1 and 3). Coexistence of autoantibodies of bullous pemphigoid and pemphigus in a patient is rare. Read More

    Acute renal failure in a patient with epidermolysis bullosa acquisita.
    An Bras Dermatol 2017 ;92(5 Suppl 1):14-16
    Department of Dermatology, Shandong Provincial Hospital for Skin Diseases, Shandong University, Shandong , China.
    Epidermolysis bullosa acquisita is a severe autoimmune subepidermal bullous disease. In this report, we described for the first time a patient with epidermolysis bullosa acquisita who developed acute renal failure. There is a possibility that epidermolysis bullosa acquisita and acute renal failure's pathogenesis shared some common autoimmune pathways. Read More

    Neutrophilic dermatoses: Kids are not just little people.
    Clin Dermatol 2017 Nov - Dec;35(6):541-554. Epub 2017 Aug 3.
    Department of Dermatology, University of Connecticut Health Center, Farmington, CT. Electronic address:
    Neutrophilic dermatoses are a group of inflammatory skin disorders characterized by an overactive innate immune system with dysregulation of neutrophils without underlying infectious etiology. The major representative conditions discussed are Sweet syndrome; pyoderma gangrenosum; neutrophilic eccrine hidradenitis; palmoplantar eccrine hidradenitis; subcorneal pustular dermatoses; bowel-associated dermatosis arthritis syndrome; and synovitis, acne, pustulosis, hyperostosis, and osteitis. We will also discuss other neutrophilic conditions present almost exclusively in the pediatric population, including congenital erosive and vesicular dermatosis with reticulated supple scarring and the recently described group of autoinflammatory diseases. Read More

    A Novel Mutation in Junctional Plakoglobin Causing Lethal Congenital Epidermolysis Bullosa.
    J Pediatr 2017 Dec;191:266-269.e1
    Department of Pediatrics, Columbia University, New York, NY; Department of Pathology and Cell Biology, Columbia University, New York, NY.
    We report a case of neonatal generalized erythema and epidermolysis resulting from a novel mutation in the junctional plakoglobin gene causing truncation of the plakoglobin protein. Expedited genetic testing enabled diagnosis while the patient was in the neonatal intensive care unit, providing valuable information for the clinicians and family. Read More

    Aggressive periodontitis associated with Kindler syndrome in a large Kindler syndrome pedigree.
    Turk J Pediatr 2017 ;59(1):56-61
    Departments of Dermatology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
    Talo-Yıldırım T, Acun-Kaya F, Taşkesen M, Dündar S, Bozoğlan A, Tekin GG, Akdeniz S. Aggressive periodontitis associated with Kindler syndrome in a large Kindler syndrome pedigree. Turk J Pediatr 2017; 59: 56-61. Read More

    Dyshidrosiform pemphigoid localized on the hands in a child: a rare occurrence.
    An Bras Dermatol 2017 Sep-Oct;92(5):714-716
    Pt. B. D. Sharma, Post Graduate Institute of Medical Sciences - Rohtak- Haryana, India.
    Dyshidrosiform pemphigoid is an acquired autoimmune variant of bullous pemphigoid with persistent vesicobullous eruptions localized on the palms or soles, or both. It generally occurs in the elderly and is rarely reported in childhood. Hereby, we describe the first case of dyshidrosiform pemphigoid in a 12-year-old child, which was limited to the dorsal hands and treated successfully with dapsone (diaminodiphenyl sulfone). Read More

    Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals.
    An Bras Dermatol 2017 Sep-Oct;92(5):661-667
    Stricto Sensu Postgraduate Program In Health Sciences of Fundação de Ensino e Pesquisa em Ciências da Saúde (FEPECS) - Brasília (DF), Brazil.
    Background: Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions.

    Objectives: To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil. Read More

    [A case of Orf disease complicated by erythema multiforme].
    Arch Pediatr 2017 Dec 16;24(12):1241-1243. Epub 2017 Nov 16.
    Service d'accueil des urgences, American Memorial Hospital, CHU de Reims, 47, rue Cognacq-Jay, 51100 Reims, France.
    Ecthyma contagiosum, or Orf, is a specific infection of small ruminants accidentally reaching humans. Few cases have been reported in the literature to date. We report here a case of ecthyma contagiosum occurred in a 9-year-old girl after contact with a flock of ecthyma sheep. Read More

    Evaluation of anti-desmoglein-1 and anti-desmoglein-3 autoantibody titers in pemphigus patients at the time of the initial diagnosis and after clinical remission.
    Medicine (Baltimore) 2017 Nov;96(46):e8801
    Unit of Dermatology, University of Padua, Padova, Italy.
    It has been suggested that anti-desmoglein autoantibody titers could be helpful in follow-up and therapeutic management of pemphigus patients. However, there is no consensus regarding the relationship between anti-desmoglein autoantibody titers and clinical activity of pemphigus.The aim of our study was to evaluate if clinical remission of pemphigus relates to the presence of anti-desmoglein autoantibodies. Read More

    Regeneration of the entire human epidermis using transgenic stem cells.
    Nature 2017 11 8;551(7680):327-332. Epub 2017 Nov 8.
    Center for Regenerative Medicine "Stefano Ferrari", Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
    Junctional epidermolysis bullosa (JEB) is a severe and often lethal genetic disease caused by mutations in genes encoding the basement membrane component laminin-332. Surviving patients with JEB develop chronic wounds to the skin and mucosa, which impair their quality of life and lead to skin cancer. Here we show that autologous transgenic keratinocyte cultures regenerated an entire, fully functional epidermis on a seven-year-old child suffering from a devastating, life-threatening form of JEB. Read More

    Association between pemphigus and psoriasis: A population-based large-scale study.
    J Am Acad Dermatol 2017 Dec;77(6):1174-1175
    Department of Quality Measurements and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel; Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

    Diagnostic Utility and Pitfalls of Tzanck Smear Cytology in Diagnosis of Various Cutaneous Lesions.
    J Cytol 2017 Oct-Dec;34(4):179-182
    Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
    Aims: Tzanck smear is an old but useful test for diagnosis of cutaneous dermatoses. The aim of this study was to highlight the potential usefulness and diagnostic pitfalls of Tzanck smear for diagnosis of cutaneous dermatoses and infections.

    Materials And Methods: This hospital based cross-sectional study was carried out on all Tzanck smears received for a period of twenty months (January 2014-August 2015). Read More

    Successful and well-tolerated bi-weekly immunoadsorption regimen in pemphigus vulgaris.
    Atheroscler Suppl 2017 Nov 3;30:271-277. Epub 2017 Jun 3.
    Department of Dermatology, University Hospital and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany. Electronic address:
    Background: Pemphigus vulgaris is a chronic autoimmune disease characterized by blisters and erosions forming in the mucous membranes and the skin. Many patients are severely impaired by pain, weight loss and increased risk of infections. The disease is mediated by specific autoantibodies directed against desmogleins that contribute to connect keratinocytes in the epidermis. Read More

    Desmoglein 3-Reactive B Cells "Hiding" in Pemphigus Lesions.
    J Invest Dermatol 2017 Nov;137(11):2255-2257
    Department of Dermatology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. Electronic address:
    Pemphigus vulgaris is an autoimmune blistering disease caused by anti-desmoglein 3 IgG autoantibodies. It is accepted that interactions between autoreactive B and T cells are key to humoral autoimmunity targeting desmoglein 3. This orchestrated process usually occurs in secondary lymphoid organs, including the spleen and lymph nodes. Read More

    Flow diverter treatment of cerebral blister aneurysms.
    Neuroradiology 2017 Dec 18;59(12):1285-1290. Epub 2017 Oct 18.
    Cerebrovascular Center, Cleveland Clinic, 9500 Euclid Ave, S80, Cleveland, OH, 44195, USA.
    Purpose: Blood blister-like aneurysms (BBA) are small, friable, broad-based aneurysms that represent high risk for rerupture. Treatment of BBA is challenging, and may include surgical wrapping, clipping, multiple overlapping stents, and/or coiling. Flow diversion is a rapidly evolving treatment strategy for intracranial aneurysms, but the evidence for its use in cases of BBA is scarce. Read More

    Prospective Clinical Trial of Corneal Reconstruction With Biomaterial-Free Cultured Oral Mucosal Epithelial Cell Sheets.
    Cornea 2018 Jan;37(1):76-83
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
    Purpose: To investigate the efficacy and safety of transplantation with biomaterial-free cultured oral mucosal epithelial cell sheets (COMECs) for ocular reconstruction in subjects with total limbal stem cell deficiency.

    Methods: A prospective clinical trial (NCT02149732) was conducted in 8 subjects with total limbal stem cell deficiency after approval from the institutional review board of Seoul National University Hospital (H-0707-043-213) and the Ministry of Food and Drug Safety of Korea. COMECs were prepared in a culture system without the use of any temperature-sensitive polymers or carriers. Read More

    Spectrum of orocutaneous disease associations: Immune-mediated conditions.
    J Am Acad Dermatol 2017 Nov;77(5):795-806
    Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:
    There are a number of diseases that manifest both on the skin and the oral mucosa, and therefore the importance for dermatologists in clinical practice to be aware of these associations is paramount. In the following continuing medical education series, we outline orocutaneous disease associations with both immunologic and inflammatory etiologies. Read More

    The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs.
    Epilepsia 2017 12 13;58(12):2178-2185. Epub 2017 Oct 13.
    Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
    Objective: Older antiepileptic drugs (AEDs) are known to cause Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). However, evidence for newer AED is sparse. We quantified risks of SJS/TEN in association with use of all AEDs in the United Kingdom. Read More

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