610 results match your criteria Subcorneal Pustular Dermatosis


Subclinical oral involvement in patients with endemic pemphigus foliaceus.

Dermatol Pract Concept 2018 Oct 31;8(4):252-261. Epub 2018 Oct 31.

School of Dentistry, University of Antioquia, Medellin, Colombia.

Background: We have described a variant of endemic pemphigus foliaceus (EPF) in El Bagre area known as pemphigus Abreu-Manu. Our previous study suggested that Colombian EPF seemed to react with various plakin family proteins, such as desmoplakins, envoplakin, periplakin BP230, MYZAP, ARVCF, p0071 as well as desmoglein 1.

Objectives: To explore whether patients affected by a new variant of endemic pemphigus foliaceus (El Bagre-EPF) demonstrated oral involvement. Read More

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October 2018
3 Reads

Imatinib-induced IgA Pemphigus: Subcorneal Pustular Dermatosis Type.

Indian Dermatol Online J 2018 Sep-Oct;9(5):331-333

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.

Imatinib mesylate, a tyrosine kinase inhibitor, is commonly used in the treatment of chronic myeloid leukemia. IgA pemphigus is a rare bullous dermatosis caused by IgA autoantibodies. Clinical manifestations include localized or generalized itchy blisters and pustules. Read More

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September 2018
6 Reads

A Case of the Co-Existence of Subcorneal Pustular Dermatosis and Pyoderma Gangrenosum and a Review of the Literature.

Open Access Maced J Med Sci 2018 Jul 8;6(7):1271-1274. Epub 2018 Jul 8.

Department of Medicine and Health Science "Vincenzo Tiberio", University of Molise, Campobasso, Italy.

Background: Subcorneal pustular dermatosis, also known as Sneddon-Wilkinson disease, can be classified as one of the neutrophilic dermatoses together with pyoderma gangrenosum. The development of both SPD and PG in the same patient has rarely been reported and may be a strong indicator of IgA dysglobulinemia.

Case Report: We report the case of a 34-year-old woman with a 2-year history of relapsing pustular eruptions mainly affecting the abdomen, gluteus region, elbows, and the extremities. Read More

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July 2018
11 Reads

Development of psoriasis by continuous neutrophil infiltration into the epidermis.

Authors:
Hiroshi Katayama

Exp Dermatol 2018 Oct 14;27(10):1084-1091. Epub 2018 Aug 14.

Katayama Dermatology Clinic, Maebashi, Japan.

Remarkable effects of anti-IL-17A and anti-IL-23 antibodies on psoriasis indicate deep involvement of IL-23/Th17 axis in the pathogenesis of psoriasis. According to the current immune theory, activation of dendritic cells initiates the generation of this axis. However, this theory is not enough to explain the mechanism, because the process of this activation is obscure and the antigen that is recognized by antigen-presenting cells and pathogenic T cells has long been unidentified. Read More

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October 2018

Pemphigus herpetiformis in South Tunisia: a clinical expression of pemphigus foliaceus?

Int J Dermatol 2018 Sep 16;57(9):1094-1101. Epub 2018 Jul 16.

Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.

Background: Pemphigus herpetiformis (PH) is a rare subtype of pemphigus combining clinical features of dermatitis herpetiformis and the immunopathologic characteristics of pemphigus. We aimed to analyze the epidemiological, clinical, and immunological presentation and management of the disease in a cohort of south Tunisian patients with a long-term follow-up.

Methods: We included all patients with confirmed PH followed from January 1987 to December 2015 in the dermatology department. Read More

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September 2018
4 Reads

Subcorneal Pustular Dermatosis: A Case Report of a Patient with Diffuse Scleroderma.

Adv Biomed Res 2018 23;7:83. Epub 2018 May 23.

Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Subcorneal pustular dermatosis (SPD) or Sneddon-Wilkinson disease is a rare, benign, chronic, sterile pustular eruption which is associated with various systemic diseases including immunoglobinopathies, neoplasms, and autoimmune disorders. This paper reports a case of SPD in a patient with diffuse scleroderma in a 37-year-old woman. The hypothesis that immune dysregulation may play a role in the pathogenesis of SPD was supposed by the coexistence of diffuse scleroderma and SPD in our patient. Read More

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May 2018
10 Reads

A Case of Ceftriaxone-Induced Acute Generalized Exanthematous Pustulosis/Generalized Pustular Psoriasis Overlap.

Case Rep Dermatol 2018 Jan-Apr;10(1):69-75. Epub 2018 Mar 27.

Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, China.

Acute generalized exanthematous pustulosis, characterized by subcorneal or superficial intraepidermal pustules, is induced by drugs in more than 90% of cases. Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. Generalized pustular psoriasis is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. Read More

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March 2018
3 Reads

Subcorneal pustular dermatosis in the pediatric age.

An Bras Dermatol 2018 Jan-Feb;93(1):116-118

Department of Dermatology. Hospital do Servidor Público Estadual de São Paulo - São Paulo (SP), Brazil.

Subcorneal pustular dermatosis is a rare pustular eruption which occurs mainly in middle-aged women and rarely during childhood. We report a case of a 15-year-old female with a 4-year history of pustular lesions on the proximal region of the upper limbs with subsequent impairment of the trunk. Physical examination revealed small pustules distributed on the trunk and proximal region of the limbs. Read More

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April 2018
1 Read

Recalcitrant psoriasiform dermatosis of the face: Is it related to pityriasis rubra pilaris?

J Cutan Pathol 2018 Jul 23;45(7):491-497. Epub 2018 Apr 23.

National Skin Centre, Singapore.

Background: There are patients with recalcitrant psoriasiform plaques that do not fit into conventional categories of facial dermatoses. Our study aims to describe the clinicopathological characteristics of several patients with a unique presentation of persistent psoriasiform facial rashes.

Methods: This retrospective cross-sectional study analyzed clinical and histological data of known cases of recalcitrant psoriasiform dermatosis of the face diagnosed at National Skin Centre, Singapore, over 10 years. Read More

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July 2018
14 Reads

Neutrophilic dermatoses: a broad spectrum of disease.

G Ital Dermatol Venereol 2018 Apr 24;153(2):265-272. Epub 2018 Jan 24.

Unit of Dermatology, Carlo Urbai Hospital, AREA Vasta 2 ASUR Marche, Jesi, Ancona, Italy -

The neutrophilic dermatoses (NDs) comprise a group of heterogeneous disorders characterized by inflammatory skin lesions that histologically show an intense inflammatory infiltrate composed primarily by neutrophils, with no evidence of infection or vasculitis. Although there are distinct clinical differences in the classical lesions of these disorders, many patients have overlapping features. In this review, we describe the clinical aspects of the main NDs, including: Sweet Syndrome, ND of the dorsal hands, pyoderma gangrenosum, erythema elevatum diutinum, subcorneal pustular dermatosis, neutrophilic eccrine hidradenitis, rheumatoid neutrophilic dermatitis, neutrophilic panniculitis, and aseptic abscesses including their association with underlying diseases and the differential diagnoses. Read More

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April 2018
4 Reads

Neutrophilic dermatoses: Kids are not just little people.

Clin Dermatol 2017 Nov - Dec;35(6):541-554. Epub 2017 Aug 3.

Department of Dermatology, University of Connecticut Health Center, Farmington, CT. Electronic address:

Neutrophilic dermatoses are a group of inflammatory skin disorders characterized by an overactive innate immune system with dysregulation of neutrophils without underlying infectious etiology. The major representative conditions discussed are Sweet syndrome; pyoderma gangrenosum; neutrophilic eccrine hidradenitis; palmoplantar eccrine hidradenitis; subcorneal pustular dermatoses; bowel-associated dermatosis arthritis syndrome; and synovitis, acne, pustulosis, hyperostosis, and osteitis. We will also discuss other neutrophilic conditions present almost exclusively in the pediatric population, including congenital erosive and vesicular dermatosis with reticulated supple scarring and the recently described group of autoinflammatory diseases. Read More

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July 2018
7 Reads

Intracorneal pustular drug eruption, a novel cutaneous adverse event in anti-programmed cell death-1 patients that highlights the effect of anti-programmed cell death-1 in neutrophils.

Melanoma Res 2017 12;27(6):641-644

aDepartment of Dermatology bDepartment of Pathology, Institute for Clinical Pathology and Medical Research, Westmead Hospital cDepartment of Dermatology, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.

The introduction of anti-programmed cell death-1 (anti-PD1) monoclonal antibodies has revolutionized the treatment of various advanced malignancies. Despite its efficacy, anti-PD1 therapy is accompanied by a variety of cutaneous adverse events. A 79-year-old man developed erythematous scaly plaques and pustules of the forehead, legs and arms after four cycles of nivolumab infusions every 2 weeks. Read More

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December 2017
9 Reads

Drug management of neutrophilic dermatoses.

Expert Rev Clin Pharmacol 2017 Oct 27;10(10):1119-1128. Epub 2017 Jul 27.

b UOC Dermatologia, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti , Università Degli Studi di Milano , Milan , Italy.

Introduction: Neutrophilic dermatoses are a heterogenous group of chronic, cutaneous inflammatory conditions characterized by the accumulation of neutrophils in the skin and by systemic inflammation. Neutrophilic dermatoses can be idiopathic or associated with other inflammatory or systemic diseases, including the group of the hereditary, autoinflammatory syndromes. Clinical management is challenging, due to limited clinical evidence and lack of clinical practice guidelines. Read More

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October 2017
5 Reads

Intracorneal Hematoma Showing Clinical and Dermoscopic Features of Acral Lentiginous Melanoma.

Case Rep Dermatol Med 2017 8;2017:3509146. Epub 2017 May 8.

Department of Dermatology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany.

Intra- and subcorneal hematoma, a skin alteration seen palmar and plantar after trauma or physical exercise, can be challenging to distinguish from in situ or invasive acral lentiginous melanoma. Thus, careful examination including dermoscopic and histologic assessment may be necessary to make the correct diagnosis. We here present a case of a 67-year-old healthy female patient who presented with a pigmented plantar skin alteration. Read More

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May 2017
4 Reads

Interruption of Sneddon-Wilkinson Subcorneal Pustulation with Infliximab.

Case Rep Dermatol 2017 Jan-Apr;9(1):140-144. Epub 2017 Apr 27.

aDepartment of Dermatology, University Hospital of Zurich, Zurich, Switzerland.

Subcorneal pustular dermatosis (SCPD, Sneddon-Wilkinson disease) is a rare chronic-relapsing skin disorder that typically manifests as flaccid sterile pustules without systemic symptoms. Although the accumulation of neutrophils is acknowledged to be a hallmark of SCPD, its exact pathomechanism is still not known. Several chemotactic factors have been implicated in neutrophil recruitment and invasion, including the proinflammatory cytokine TNF-α. Read More

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April 2017
6 Reads

Case of shift from linear immunoglobulin A bullous dermatosis to pemphigus herpetiformis for a short period of time.

J Dermatol 2017 Feb 5;44(2):189-193. Epub 2016 Nov 5.

Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.

Pemphigus herpetiformis (PH) is a rare variant of pemphigus characterized by erythemas and vesicles, tending to present with annular-shaped lesions. Immunologically, immunoglobulin (Ig)G deposition at the keratinocyte cell surfaces is observed. Linear IgA bullous dermatosis (LABD) is a rare subepidermal blistering disease with linear IgA deposits at the epidermal basement membrane zone (BMZ). Read More

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February 2017
28 Reads

Amicrobial pustulosis of the folds: Where have we gone 25years after its original description?

Ann Dermatol Venereol 2017 Mar 24;144(3):169-175. Epub 2017 Feb 24.

Clinique dermatologique, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France. Electronic address:

Background: Twenty-five years ago at the Journées Dermatologiques de Paris, Prof. Béatrice Crickx described a new association, "antimicrobial pustulosis and systemic lupus erythematosus", a condition now known as amicrobial pustulosis of the folds (APF). The aim of this study is to analyse the clinical and laboratory characteristics of APF and to outline the gradual advancement of knowledge regarding this disease. Read More

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March 2017
6 Reads

Subcorneal pustular dermatosis and episcleritis associated with poorly controlled ulcerative colitis.

BMJ Case Rep 2017 Jan 30;2017. Epub 2017 Jan 30.

Department of Dermatology, Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA.

A man aged 56 years with a history of ulcerative colitis (UC) status postsubtotal colectomy was hospitalised with fevers, dry cough, eye redness and a new bloody, mucoid rectal discharge. 2 months prior to admission, the dermatologist had started him on dapsone for subcorneal pustular dermatosis but did not recognise that he had recently self-discontinued mesalamine enemas, inducing a flare of his UC. After a thorough inpatient evaluation, including flexible sigmoidoscopy, active UC involving the rectal stump was determined to be driving his dermatological and ophthalmological findings. Read More

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January 2017
3 Reads

Bullous, pseudobullous, & pustular dermatoses.

Authors:
Mark R Wick

Semin Diagn Pathol 2017 May 14;34(3):250-260. Epub 2016 Dec 14.

Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, United States. Electronic address:

Several dermatoses are typified by the formation of spaces (blisters; bullae) within or beneath the epidermis. These may be acellular or filled with particular species of inflammatory cells. Etiological categories include infectious, immune-mediated, genetic, drug-related, and idiopathic lesions. Read More

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May 2017
17 Reads

Acute localized exanthematous pustulosis caused by cefoperazone and sodium sulbactam.

An Bras Dermatol 2016 Nov-Dec;91(6):808-810

The 251st Hospital of Chinese PLA - Zhangjiakou city, China.

Acute localized exanthematous pustulosis is a localized variant of acute generalized exanthematous pustulosis, which is characterized by the eruption of multiple scattered pustules following drug administration. A 72-year-old woman presented with multiple erythematous pustules on her face, which had appeared two days after using cefoperazone and sodium sulbactam. Histopathological findings showed subcorneal pustules and mixed inflammatory cell infiltration in the dermis. Read More

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May 2017
3 Reads

A child with subcorneal pustular dermatosis responded to IVIG treatment (Sneddon-Wilkinson disease).

Reumatologia 2017 30;55(6):323-327. Epub 2017 Dec 30.

Dr. Behcet Uz Children's Hospital, Izmır, Turkey.

Subcorneal pustular dermatosis (SPD) is a rare, chronic, recurrent dermatosis characterised by sterile pustules. It develops mainly in middle-aged or elder women, but is also rarely seen in children. The exact aetiology of the disease is unknown. Read More

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December 2017
1 Read

Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering.

J Dermatol Sci 2017 Mar 12;85(3):197-207. Epub 2016 Dec 12.

Dermatology, Toho University School of Medicine, Tokyo, Japan.

Background: Pemphigus foliaceus (PF) is an autoimmune blistering disease caused by autoantibodies (Abs) against desmoglein 1 (Dsg1). PF sera contain polyclonal Abs which are heterogeneous mixture of both pathogenic and non-pathogenic Abs, as shown by isolation of monoclonal Abs (mAbs).

Objective: To investigate how pathogenic and non-pathogenic anti-Dsg1 Abs contribute to blister formation in PF. Read More

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March 2017
3 Reads

Amicrobial pustulosis of the folds: Report of 4 cases.

J Cutan Pathol 2017 Apr 19;44(4):367-372. Epub 2017 Jan 19.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

Amicrobial pustulosis of the folds (APF) is a rare disease characterized by aseptic pustular lesions involving cutaneous folds, typically occurring in the context of an autoimmune disorder. We present 4 patients with APF, focusing on clinical and histopathologic characteristics to improve the recognition of this entity. All 4 patients had intertriginous and extra-intertriginous involvement. Read More

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April 2017
7 Reads

Establishing a canine superficial pyoderma model.

J Appl Microbiol 2017 Feb 4;122(2):331-337. Epub 2017 Jan 4.

Department of Population Health and Pathology, College of Veterinary Medicine, NC State University, Raleigh, NC, USA.

Aims: Pyoderma, predominantly associated with Staphylococcus pseudintermedius, is a common skin infection of dogs that typically requires long-lasting treatments, complicated by increasing antimicrobial resistance. To investigate new treatment strategies, we aimed at establishing a dog model of pyoderma that closely mimics the natural disease.

Methods And Results: We inoculated six laboratory beagles with a methicillin-susceptible strain of S. Read More

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February 2017
12 Reads

IgA pemphigus showing IgA antibodies to desmoglein 1 and 3.

Dermatol Pract Concept 2016 Oct 31;6(4):31-33. Epub 2016 Oct 31.

Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia.

Background: IgA pemphigus is a rare autoimmune vesiculo-pustular skin disease. Only approximately 70 cases have been reported to date. We report a case of IgA pemphigus with IgA antibodies to desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3). Read More

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October 2016
6 Reads

Generalized pustular psoriasis induced by systemic steroid dose reduction.

An Bras Dermatol 2016 Sep-Oct;91(5):664-666

Fundação Alfredo da Matta (Fuam) - Manaus (AM), Brazil.

Generalized pustular psoriasis, or psoriasis of von Zumbusch, is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. In this work, we report the case of a female patient, 70 years old, who developed generalized pustular psoriasis symptoms while reducing the dose of oral corticosteroids, improperly introduced for the treatment of alleged acute generalized exanthematous pustulosis. The differential diagnosis of generalized pustular psoriasis should be made with other pustular dermatoses, such as subcorneal pustulosis, IgA pemphigus and especially with acute generalized exanthematous pustulosis. Read More

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May 2017
5 Reads

'Hints' in the horn: diagnostic clues in the stratum corneum.

J Cutan Pathol 2017 Mar 6;44(3):256-278. Epub 2017 Jan 6.

Department of Dermatopathology, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

The stratum corneum or horny layer is the uppermost layer of the epidermis, and is mainly responsible for the skin's barrier function. In spite of its complexity at the ultrastructural and molecular level, the features accessible to visualization on conventional histology are relatively limited. Nevertheless, knowledge of subtle clues that one may observe in the stratum corneum can prove useful in a wide range of situations in dermatopathology. Read More

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March 2017
12 Reads

Pemphigus herpetiformis - a case report of a rare form of pemphigus and review of the literature.

Vojnosanit Pregl 2016 Oct;73(10):967-72

Introduction: Pemphigus herpetiformis is the rare variant of pemphigus with characteristic clinical features, histopathological findings different from the convectional pemphigus, and immunological findings consistent with pemphigus.

Case Report: We presented a 65-year-old woman with initial pruritus followed by pruritic urticarial papules and plaques, some with annular rings of tense vesicles on the periphery, on the trunk and extremities, with no mucous lesions. Histopathological examination demonstrated spongiosis and intraepidermal vesicles in the mid or subcorneal epidermis in some biopsy specimen, with neutrophil and eosinophil infiltrate. Read More

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October 2016
4 Reads

Complete remission of skin lesions in a patient with subcorneal pustular dermatosis (Sneddon-Wilkinson disease) treated with antimyeloma therapy: association with disappearance of M-protein.

Br J Dermatol 2017 May 27;176(5):1341-1344. Epub 2017 Jan 27.

Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.

Subcorneal pustular dermatosis (SPD), or Sneddon-Wilkinson disease, is a rare pustular skin disease that follows a chronic relapsing course. A well-known association exists between SPD and IgA monoclonal gammopathy of undetermined significance (MGUS), which exists in up to 40% of cases. SPD has also been observed in patients with IgA myeloma. Read More

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May 2017
1 Read

Immunohistochemical Comparison of IL-36 and the IL-23/Th17 Axis of Generalized Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis.

Ann Dermatol 2016 Aug 26;28(4):451-6. Epub 2016 Jul 26.

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

Background: Cutaneous pustular disorders include generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP).

Objective: To identify differences between GPP and AGEP, here we immunohistochemically evaluated interleukin (IL)-36 and the IL-23/Th17 axis.

Methods: This retrospective comparative immunohistochemical study was completed using 11 biopsies of 11 cases of GPP and 11 biopsies of 11 cases of AGEP. Read More

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August 2016
1 Read

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress.

Am J Clin Dermatol 2016 Dec;17(6):653-671

Department of Dermatology, Veterans Affairs Medical Center Brooklyn and SUNY Downstate, 800 Poly Place, Brooklyn, NY, 11209, USA.

Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare, benign yet relapsing pustular dermatosis. Its incidence and prevalence have not been well studied. It characteristically presents as hypopyon pustules on the trunk and intertriginous areas of the body. Read More

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December 2016
10 Reads

A Clinicopathological Study of Pemphigus in Eastern India with Special Reference to Direct Immunofluorescence.

Indian J Dermatol 2016 May-Jun;61(3):288-94

Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India.

Background: Pemphigus is a group of chronic autoimmune vesico-bullous disorders in which the epidermis and the basement membrane zone are the focus of attack resulting in cutaneous and mucosal blister formation. Direct immunofluorescence (DIF) test is a very sensitive test for the diagnosis.

Aim: To study the clinico histopathological patterns of pemphigus in eastern India. Read More

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June 2016
6 Reads

Clinical and immunological studies of 49 cases of various types of intercellular IgA dermatosis and 13 cases of classical subcorneal pustular dermatosis examined at Kurume University.

Br J Dermatol 2017 Jan 17;176(1):168-175. Epub 2016 Oct 17.

Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka, 830-0011, Japan.

Background: Intercellular IgA dermatosis (IAD) is a subset of autoimmune bullous disease exclusively with IgA antikeratinocyte cell-surface antibodies. The classification and pathogenesis of this condition are still obscure.

Objectives: To classify IAD and study its pathogenesis. Read More

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January 2017
7 Reads

Acute Generalized Exanthematous Pustulosis Induced by Fexofenadine.

Indian J Dermatol 2016 Mar-Apr;61(2):235

Department of Dermatology and Venereology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India.

Acute generalized exanthematous pustulosis (AGEP) is a skin eruption, frequently drug induced and characterized by the acute development of multiple sterile minute pustules on an erythematous base. There is no case of fexofenadine-induced AGEP in literature (PubMed search). A 40-year-old female presented to us with fever and sudden onset development of multiple discrete to coalescent 1-2 mm nonfollicular pustules on an erythematous base present mainly on her trunk and upper extremities for past 2 days. Read More

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April 2016
8 Reads

Ipilimumab-induced acute generalized exanthematous pustulosis in a patient with metastatic melanoma.

Melanoma Res 2016 08;26(4):417-20

Departments of aDermatology bTissue Pathology, Westmead Hospital cSydney Medical School, The University of Sydney dFaculty of Medicine, Western Sydney University, New South Wales, Australia.

Ipilimumab is a new anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody that stimulates the immune response against melanoma. A 50-year-old man received ipilimumab for metastatic melanoma as part of a clinical trial. Two weeks after drug initiation, he developed a widespread oedematous erythema with sterile pustules. Read More

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August 2016
3 Reads

Prolonged pustular eruption from hydroxychloroquine: an unusual case of acute generalized exanthematous pustulosis.

Cutis 2016 Mar;97(3):212-6

University of North Carolina, Chapel Hill, USA.

Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous eruption that often is a reaction to medications, most commonly antibiotics. Clinically, AGEP closely mimics pustular psoriasis and also is similar to subcorneal pustular dermatosis and IgA pemphigus. For clinicians, it is important to differentiate AGEP from pustular psoriasis. Read More

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March 2016
23 Reads

Subcorneal hematomas in excessive video game play.

Cutis 2016 Jan;97(1):35-8

Women & Children's Hospital of Buffalo, New York, USA.

We report a case of subcorneal hematomas caused by excessive video game play in a 19-year-old man. The hematomas occurred in a setting of thrombocytopenia secondary to induction chemotherapy for acute myeloid leukemia. It was concluded that thrombocytopenia subsequent to prior friction from heavy use of a video game controller allowed for traumatic subcorneal hemorrhage of the hands. Read More

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January 2016
1 Read

Classification of Extrapulmonary Manifestations Due to Mycoplasma pneumoniae Infection on the Basis of Possible Pathogenesis.

Authors:
Mitsuo Narita

Front Microbiol 2016 28;7:23. Epub 2016 Jan 28.

Department of Pediatrics, Sapporo Tokushukai Hospital Sapporo, Japan.

The list of extrapulmonary manifestations due to Mycoplasma pneumoniae infection can be classified according to the following three possible mechanisms derived from the established biological activity of M. pneumoniae; (1) a direct type in which the bacterium is present at the site of inflammation and local inflammatory cytokines induced by the bacterium play an important role (2) an indirect type in which the bacterium is not present at the site of inflammation and immune modulations, such as autoimmunity or formation of immune complexes, play an important role, and (3) a vascular occlusion type in which obstruction of blood flow induced either directly or indirectly by the bacterium plays an important role. Recent studies concerning extrapulmonary manifestations have prompted the author to upgrade the list, including cardiac and aortic thrombi as cardiovascular manifestations; erythema nodosum, cutaneous leukocytoclastic vasculitis, and subcorneal pustular dermatosis as dermatological manifestations; acute cerebellar ataxia, opsoclonus-myoclonus syndrome, and thalamic necrosis as neurological manifestations; pulmonary embolism as a respiratory system manifestation; and renal artery embolism as a urogenital tract manifestation. Read More

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February 2016
7 Reads

Histopathological study and F1L gene sequence analysis of contagious ecthyma in small ruminants of Shiraz suburb, Iran.

Trop Biomed 2015 Jun;32(2):335-43

Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Contagious ecthyma, also known as Orf, is a common viral skin disease of sheep and goats caused by a Parapoxvirus. This research was conducted with the aims of histopathological study and genetic analysis of Orf virus with PCR technique based on F1L gene in 50 sheep and goats suspicious of contagious ecthyma in affected areas of Shiraz suburb. All 50 contagious ecthyma-like tissue samples were maintained in 10% buffered formalin, embedded in paraffin, sectioned into 5μm slices and dyed with hematoxylin-eosine. Read More

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June 2015
2 Reads

Scabies Incognito Presenting as a Subcorneal Pustular Dermatosis-like Eruption.

Turkiye Parazitol Derg 2015 Sep;39(3):244-7

Department of Dermatology, İzmir Atatürk Training and Research Hospital, İzmir, Turkey.

Scabies is a common parasitosis of the skin caused by Sarcoptes scabiei hominis. This infestation occurs in all geographic areas and across all age groups, races, and social classes. Poor economic conditions and lack of proper hygiene are risk factors for the disease. Read More

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September 2015
3 Reads

Subcorneal pustular dermatosis associated with Coccidioides immitis.

Dermatol Online J 2015 Aug 15;21(8). Epub 2015 Aug 15.

University of California, Davis.

Coccidioidomycosis (AKA "Valley fever") is a primary pulmonary infection via airborne spores released from coccidioides immitis in the soil. Reactive cutaneous eruptions resulting from the pulmonary infection are difficult to diagnose because skin biopsies do not contain the organism. We present an adolescent male with primary pulmonary C. Read More

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August 2015
4 Reads

Histopathologic features of erythematous papulopustular eruption to epidermal growth factor receptor inhibitors in cancer patients.

J Cutan Pathol 2016 Mar 17;43(3):211-8. Epub 2015 Nov 17.

Clinical, Allergological and Venereological Dermatology Section, Department of Medicine, University of Perugia, Perugia, Italy.

Background: Erythematous papulopustular eruption (EPPE) is the most frequent skin adverse event to epidermal growth factor receptor (EGFR) inhibitors but its histopathologic features have been poorly studied. As EPPE is a strong predictor of patient's treatment response, the EPPE histopathologic features and their correlations with skin eruption severity and involved drug were investigated.

Method: An involved skin biopsy was carried out in 39 informed patients treated with EGFR inhibitors (mainly cetuximab and erlotinib). Read More

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The Incidence of Acantholysis in Pityriasis Rubra Pilaris-Histopathological Study Using Multiple-Step Sections and Clinicopathologic Correlations.

Am J Dermatopathol 2015 Oct;37(10):755-8

*Department of Dermatology, Rambam Health Care Campus, Haifa, Israel; and †The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.

Background: The classical histopathological findings in the epidermis of pityriasis rubra pilaris (PRP) do not include acantholysis; however, acantholysis was described in several case reports and a few series of PRP with variable frequencies. We sought to establish the incidence of acantholysis in biopsies from consecutively referred PRP cases using multiple-step sections and clinicopathologic correlations.

Methods: Twenty-three biopsies from 12 consecutively referred patients with classical (type 1) PRP were studied histopathologically. Read More

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October 2015
10 Reads

Acute generalized exanthematous pustulosis (AGEP): A review and update.

J Am Acad Dermatol 2015 Nov 6;73(5):843-8. Epub 2015 Sep 6.

Dermatology, Rutgers New Jersey Medical School, Newark, New Jersey; Pathology, Rutgers New Jersey Medical School, Newark, New Jersey; Medicine, Rutgers New Jersey Medical School, Newark, New Jersey; Pediatrics, Rutgers New Jersey Medical School, Newark, New Jersey; Preventive Medicine and Community Health, Rutgers New Jersey Medical School, Newark, New Jersey; Rutgers University School of Public Affairs and Administration, Newark, New Jersey. Electronic address:

Acute generalized exanthematous pustulosis is a severe cutaneous adverse reaction characterized by the rapid development of nonfollicular, sterile pustules on an erythematous base. It is attributed to drugs in the majority of cases. Antibiotics are the most common cause of acute generalized exanthematous pustulosis; however, a wide variety of drugs has been associated with this condition. Read More

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November 2015
5 Reads

A case of subcorneal pustular dermatosis with IgG monoclonal gammopathy of undetermined significance: a rare association.

Int J Dermatol 2015 Dec 4;54(12):e551-3. Epub 2015 Sep 4.

Department of Dermatology, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey.

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December 2015
8 Reads

When Rings Are Not Ringworms: Case Reports and Review of Literature.

Conn Med 2015 Feb;79(2):77-80

Presented are two cases of subcorneal pustular dermatosis (SPD), one of which was initially confused with, and treated as, a fungal infection. Eventually both cases were successfully treated with dapsone. The exact etiology and pathophysiology of SPD remains unclear and so does its classification. Read More

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February 2015
1 Read

Benign dermoscopic parallel ridge pattern in plantar hyperpigmentation due to capecitabine.

Dermatol Pract Concept 2015 Apr 30;5(2):79-81. Epub 2015 Apr 30.

Department of Clinical Medicine and Immunological Sciences, Dermatology Section, University of Siena, Siena, Italy.

We report the case of a 37-year-old woman (phototype II) who presented at our outpatient clinic with a two-month history of hyperpigmented plantar macules. Medical history revealed that the patient had taken capecitabine in the past three months as adjuvant chemotherapy for recurrent breast cancer. Dermoscopic examination of the plantar macules showed parallel ridge pattern with pigmentation in the furrows without obliteration of eccrine gland apertures. Read More

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April 2015
3 Reads

PUM I Revisited: Tradeoffs in Preservation and Discovery.

Anat Rec (Hoboken) 2015 Jun;298(6):949-53

University of Pennsylvania Museum of Archaeology and Anthropology, Philadelphia, Pennsylvania.

An Egyptian mummy designated PUM I (Pennsylvania University Museum) was subjected to a complete autopsy in 1972. Forty-one years later, the senior author (MZ) was invited back to the Penn Museum to identify several packages of material that had been preserved with the mummy joining the project conservator (MG) in the evaluation of these remains. A summary of the 1972 examination reviews the dating of the mummy, about 3,000 years ago. Read More

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June 2015
1 Read

Successful treatment of subcorneal pustular dermatosis with maxacalcitol.

Clin Exp Dermatol 2016 Jan 19;41(1):102-3. Epub 2015 May 19.

Department of Dermatology, Hakodate Central General Hospital, Honcho 33-2, Hakodate, 040-8585, Japan.

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January 2016