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    Neutrophilic dermatoses: Kids are not just little people.
    Clin Dermatol 2017 Nov - Dec;35(6):541-554. Epub 2017 Aug 3.
    Department of Dermatology, University of Connecticut Health Center, Farmington, CT. Electronic address:
    Neutrophilic dermatoses are a group of inflammatory skin disorders characterized by an overactive innate immune system with dysregulation of neutrophils without underlying infectious etiology. The major representative conditions discussed are Sweet syndrome; pyoderma gangrenosum; neutrophilic eccrine hidradenitis; palmoplantar eccrine hidradenitis; subcorneal pustular dermatoses; bowel-associated dermatosis arthritis syndrome; and synovitis, acne, pustulosis, hyperostosis, and osteitis. We will also discuss other neutrophilic conditions present almost exclusively in the pediatric population, including congenital erosive and vesicular dermatosis with reticulated supple scarring and the recently described group of autoinflammatory diseases. Read More

    Aggressive periodontitis associated with Kindler syndrome in a large Kindler syndrome pedigree.
    Turk J Pediatr 2017 ;59(1):56-61
    Departments of Dermatology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
    Talo-Yıldırım T, Acun-Kaya F, Taşkesen M, Dündar S, Bozoğlan A, Tekin GG, Akdeniz S. Aggressive periodontitis associated with Kindler syndrome in a large Kindler syndrome pedigree. Turk J Pediatr 2017; 59: 56-61. Read More

    Evaluation of anti-desmoglein-1 and anti-desmoglein-3 autoantibody titers in pemphigus patients at the time of the initial diagnosis and after clinical remission.
    Medicine (Baltimore) 2017 Nov;96(46):e8801
    Unit of Dermatology, University of Padua, Padova, Italy.
    It has been suggested that anti-desmoglein autoantibody titers could be helpful in follow-up and therapeutic management of pemphigus patients. However, there is no consensus regarding the relationship between anti-desmoglein autoantibody titers and clinical activity of pemphigus.The aim of our study was to evaluate if clinical remission of pemphigus relates to the presence of anti-desmoglein autoantibodies. Read More

    Diagnostic Utility and Pitfalls of Tzanck Smear Cytology in Diagnosis of Various Cutaneous Lesions.
    J Cytol 2017 Oct-Dec;34(4):179-182
    Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
    Aims: Tzanck smear is an old but useful test for diagnosis of cutaneous dermatoses. The aim of this study was to highlight the potential usefulness and diagnostic pitfalls of Tzanck smear for diagnosis of cutaneous dermatoses and infections.

    Materials And Methods: This hospital based cross-sectional study was carried out on all Tzanck smears received for a period of twenty months (January 2014-August 2015). Read More

    Desmoglein 3-Reactive B Cells "Hiding" in Pemphigus Lesions.
    J Invest Dermatol 2017 Nov;137(11):2255-2257
    Department of Dermatology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. Electronic address:
    Pemphigus vulgaris is an autoimmune blistering disease caused by anti-desmoglein 3 IgG autoantibodies. It is accepted that interactions between autoreactive B and T cells are key to humoral autoimmunity targeting desmoglein 3. This orchestrated process usually occurs in secondary lymphoid organs, including the spleen and lymph nodes. Read More

    Spectrum of orocutaneous disease associations: Immune-mediated conditions.
    J Am Acad Dermatol 2017 Nov;77(5):795-806
    Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:
    There are a number of diseases that manifest both on the skin and the oral mucosa, and therefore the importance for dermatologists in clinical practice to be aware of these associations is paramount. In the following continuing medical education series, we outline orocutaneous disease associations with both immunologic and inflammatory etiologies. Read More

    A comparative study of expression of Fc receptors in relation to the autoantibody-mediated immune response and neutrophil elastase expression in autoimmune blistering dermatoses.
    Pol J Pathol 2017;68(2):109-116
    Here we investigated the cutaneous CD32A and CD89 expression in relation to the neutrophil elastase (NE) expression and serum level of anti-desmoglein 1 and 3 (DSG1/DSG3) IgG in pemphigus, anti-BP180/BP230 IgG in bullous pemphigoid (BP), anti-gliadin nonapeptides (npG), tissue (tTG), and epidermal transglutaminases (eTG) IgA in dermatitis herpetiformis (DH). The examined material consisted of skin/mucosal tissues and sera. In total, 87 patients were studied. Read More

    Spatial Distribution of Pemphigus Occurrence over Five Decades in Southeastern Brazil.
    Am J Trop Med Hyg 2017 Dec 21;97(6):1737-1745. Epub 2017 Sep 21.
    Department of Maternal-Infant Nursing and Public Health, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
    Well-defined locations of pemphigus cases support the hypothesis of environmental factors' involvement in its etiopathogenesis; however, these foci have never been described using specialized geographical tools. This is the first report to geo-reference pemphigus cases in a high-prevalence Brazilian region using geographic information systems. We aimed to report the spatio-temporal behavior of pemphigus foliaceus (PF) and vulgaris (PV) in southeastern Brazil, over the last five decades to describe geographical clusters, as well as to characterize the land use in the city with the highest number of cases. Read More

    Case Report: Bullous Scabies in Two Children below 10 Years.
    Am J Trop Med Hyg 2017 Dec 21;97(6):1746-1748. Epub 2017 Sep 21.
    Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
    Bullous scabies is an infrequent and atypical presentation of scabies, with predilection for elderly and males. Its median age of presentation is 70 years. We report two male cases of bullous scabies who were 7 years and 6 months old. Read More

    Young donor-graft assisted endothelial keratoplasty (PDEK/DMEK) with epithelial debridement for chronic pseudophakic bullous keratopathy.
    Can J Ophthalmol 2017 Oct 16;52(5):519-526. Epub 2017 May 16.
    Dr. Agarwal's Eye Hospital & Research Centre, Chennai, India.
    Objective: The aim of this study was to describe the applicability and report visual outcomes for the treatment of subepithelial fibrosis and anterior stromal scarring in cases of chronic pseudophakic bullous keratopathy (PBK) with epithelial debridement and endothelial keratoplasty (EK) (pre-Descemet endothelial keratoplasty [PDEK]; Descemet membrane endothelial keratoplasty [(DMEK]) using young donor tissue.

    Design: Prospective, single-centre, interventional study.

    Participants: 6 cases with chronic PBK (> 1 year duration). Read More

    Recurrent impetigo herpetiformis: case report.
    Pan Afr Med J 2017 24;27:219. Epub 2017 Jul 24.
    Faculty of Health Sciences, Egerton University, Njoro, Kenya.
    Impetigo herpetiformis (pustular psoriasis of pregnancy) is a rare dermatosis of pregnancy that typically starts in the 2nd half of pregnancy and resolves postpartum. It may recur in subsequent pregnancies. I present a case of 23 year old female gravida 4 para 3 with recurrent impetigo herpetiformis at 26 weeks gestation. Read More

    An RNA-targeted therapy for dystrophic epidermolysis bullosa.
    Nucleic Acids Res 2017 Sep;45(17):10259-10269
    EB House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University Salzburg, Austria.
    Functional impairment or complete loss of type VII collagen, caused by mutations within COL7A1, lead to the severe recessive form of the skin blistering disease dystrophic epidermolysis bullosa (RDEB). Here, we successfully demonstrate RNA trans-splicing as an auspicious repair option for mutations located in a wide range of exons by fully converting an RDEB phenotype in an ex vivo pre-clinical mouse model based on xenotransplantation. Via a self-inactivating (SIN) lentiviral vector a 3' RNA trans-splicing molecule, capable of replacing COL7A1 exons 65-118, was delivered into type VII collagen deficient patient keratinocytes, carrying a homozygous mutation in exon 80 (c. Read More

    [Epidermolysis bullosa: oral manifestations and their treatments].
    Orv Hetil 2017 Oct;158(40):1577-1583
    Konzerváló és Esztétikai Fogászati Tanszék, Szegedi Tudományegyetem, Fogorvostudományi Kar, Szeged, Tisza L. krt. 64-66., 6720.
    The aim of this comprehensive article is to provide guidelines for the daily treatment of patients with epidermolysis bullosa, thus contributing to the attainment of their higher quality of life through the improvement of their oral health. Moreover, it is our intention to facilitate the cooperation among Hungarian general practitioners, dermatologists and dentists. Relying on recent research findings of the international literature, we intend to help general practitioners or dermatologists treating epidermolysis bullosa patients on a daily basis by identifying symptoms that require consulting an oral professional on the one hand, and to present the most important prevention strategies and further treatments advised for dentists on the other. Read More

    Clinical evaluation of a multiparametric ELISA as a rapid tool for routinely diagnosing IgG-mediated autoimmune blistering dermatoses in ethnic Slavs.
    J Clin Lab Anal 2017 Sep 26. Epub 2017 Sep 26.
    Autoimmune Blistering Dermatoses Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
    Background: Technical innovation of autoimmune blistering dermatoses (ABDs) diagnosis aimed at multiplex approach. Two multiparametric ELISA tests are commercially available for ABDs serology. The aim was to compare diagnostic accuracy of multiparametric and monospecific ELISAs and to examine the diagnostic value/agreement of multivariant ELISA in compliance with traditional diagnostic setup for ABDs. Read More

    New Evidence Supporting Cyclosporine Efficacy in Epidermal Necrolysis.
    J Invest Dermatol 2017 Oct;137(10):2047-2049
    Paris, France (retired).
    Sixty years after its original description by Sir Alan Lyell, epidermal necrolysis (from Stevens-Johnson syndrome to toxic epidermal necrolysis) seems finally amenable to a specific treatment in addition to essential symptomatic measures in specialized settings. A recently published systematic review and an article by Gonzales-Herrada et al. strongly suggest that cyclosporine is effective in reducing the risk of death. Read More

    Atypical features and systemic associations in extensive cases of Grover disease: A systematic review.
    J Am Acad Dermatol 2017 Nov 14;77(5):952-957.e1. Epub 2017 Sep 14.
    Department of Pathology, University of California, San Francisco, California. Electronic address:
    Background: Grover disease is an acantholytic disorder that typically occurs on the trunk of older individuals, primarily white men, in association with heat and xerosis. Cases with extensive and/or atypical distributions have been reported.

    Objective: To review the literature characterizing the population, morphology, associations, and disease course of extensive or atypical eruptions of Grover disease. Read More

    Oral mucosa biology and salivary biomarkers.
    Clin Dermatol 2017 Sep - Oct;35(5):477-483. Epub 2017 Jun 27.
    Department of Dermatology, University of California, Davis School of Medicine, Sacramento, CA. Electronic address:
    Although the surfaces of both the skin and oral mucosa are protected by squamous epithelial cells and fall within the scope of dermatologic practice, the oral cavity contains highly specialized structures and functions distinct from other skin biology and pathologic conditions and are also the purview of clinicians who care for patients with skin and mucosal diseases. We describe the distinct features of the tongue, mucosa, and salivary glands. In particular, we examine the composition and function of the saliva, with special focus on salivary biomarkers. Read More

    Successful Placement of a BAHA Implant in a Patient With Epidermolysis Bullosa: A Case Report and Review of the Literature.
    Ann Otol Rhinol Laryngol 2017 Nov 12;126(11):778-780. Epub 2017 Sep 12.
    5 Michigan Pediatric Ear, Nose, and Throat Associates, West Bloomfield, MI, USA.
    Introduction: Epidermolysis bullosa (EB) is a spectrum of mechanobullous disorders characterized by blistering following minor trauma or traction to the skin. Hearing loss in this population is poorly described in the otolaryngology literature, and its treatment oftentimes results in external auditory canal skin irritation.

    Case Presentation: We present the case of a 26-year-old female with EB and mixed hearing loss unable to wear conventional hearing aids due to sequelae of the external auditory canals. Read More

    Rapid generation of Col7a1-/- mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells.
    Lab Invest 2017 Oct 11;97(10):1218-1224. Epub 2017 Sep 11.
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
    Recessive dystrophic epidermolysis bullosa (RDEB) is a debilitating and ultimately lethal blistering disease caused by mutations to the Col7a1 gene. Development of novel cell therapies for the treatment of RDEB would be fostered by having immunodeficient mouse models able to accept human cell grafts; however, immunodeficient models of many genodermatoses such as RDEB are lacking. To overcome this limitation, we combined the clustered regularly interspaced short palindromic repeats and associated nuclease (CRISPR/Cas9) system with microinjection into NOD/SCID IL2rγcnull (NSG) embryos to rapidly develop an immunodeficient Col7a1-/- mouse model of RDEB. Read More

    Autoimmune Progesterone Dermatitis Presenting as Stevens-Johnson Syndrome.
    Obstet Gynecol 2017 Oct;130(4):881-884
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Naval Medical Center San Diego, San Diego, California.
    Background: Autoimmune progesterone dermatitis is an uncommon disease presenting with cyclical skin eruptions corresponding with the menstrual cycle luteal phase. Because symptoms are precipitated by rising progesterone levels, treatment relies on hormone suppression.

    Case: A 22-year-old nulligravid woman presented with symptoms mistaken for Stevens-Johnson syndrome. Read More

    Putative contact ketoconazole shampoo-triggered pemphigus foliaceus in a dog.
    Can Vet J 2017 Sep;58(9):914-918
    Department of Veterinary Internal Medicine, Konkuk University Veterinary Medical Teaching Hospital, #120 Neungdong-ro, Gwangjin-gu, Seoul, 143-701, South Korea.
    A 10-year-old spayed female cocker spaniel dog was referred for an evaluation of acute-onset generalized pustular cutaneous lesions following application of ketoconazole shampoo. Cytologic and histopathologic examinations of the lesions revealed intra-epidermal pustules with predominantly neutrophils and acantholytic cells. This is the first description of putative contact ketoconazole shampoo-triggered pemphigus foliaceus in a dog. Read More

    Clinical Implications of Direct Immunofluorescence Findings in Patients With Ocular Mucous Membrane Pemphigoid.
    Am J Ophthalmol 2017 Nov 30;183:48-55. Epub 2017 Aug 30.
    Ophthalmology, Duke University Eye Center, Durham, North Carolina.
    Purpose: To examine the clinical implications of positive or negative direct immunofluorescence biopsies (DIF) in patients with clinically typical ocular mucous membrane pemphigoid (MMP).

    Design: Retrospective cohort study.

    Methods: The study population was patients with clinically typical ocular MMP disease with documented DIF results who were followed for at least 1 year at the Duke University multidisciplinary ocular MMP clinic. Read More

    Primary Trabeculectomy Outcomes by Glaucoma Fellows in a Tertiary Hospital in Brazil.
    J Glaucoma 2017 Nov;26(11):1019-1024
    Department of Ophthalmology, University of Campinas, Faculdade de CiênciasMédicas-UNICAMP, Campinas, Brazil.
    Purpose: To examine outcomes of trabeculectomy with mitomycin C for uncontrolled glaucoma when performed by glaucoma trainee surgeons.

    Materials And Methods: Retrospective case series of patients who underwent trabeculectomy with mitomycin C. Primary outcome was to assess the rate of failure, which was defined as intraocular pressure in 2 consecutive visits >18 or <5 mm Hg or intraocular pressure reduction <30% from baseline, additional glaucoma surgery, or loss of light perception. Read More

    Determining the Incidence of Pneumocystis Pneumonia in Patients With Autoimmune Blistering Diseases Not Receiving Routine Prophylaxis.
    JAMA Dermatol 2017 Nov;153(11):1137-1141
    Center for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
    Importance: Pneumocystis pneumonia (PCP) is a potentially lethal opportunistic infection that primary prophylaxis can help prevent. The risk of prophylactic therapy must be weighed against the incidence of PCP in the patient population. Prophylaxis most frequently involves trimethoprim-sulfamethoxazole, with second-line therapies, including atovaquone, dapsone, and pentamide. Read More

    C-Terminal Processing of Collagen XVII Induces Neoepitopes for Linear IgA Dermatosis Autoantibodies.
    J Invest Dermatol 2017 Dec 24;137(12):2552-2559. Epub 2017 Aug 24.
    Department of Dermatology, Hokkaido University, Graduate School of Medicine, Sapporo, Japan. Electronic address:
    Transmembrane collagen XVII (COL17) is a hemidesmosomal component of basal keratinocytes that can be targeted by autoantibodies in autoimmune blistering disorders, including linear IgA dermatosis (LAD). COL17 can be physiologically cleaved within the juxtamembranous extracellular NC16A domain, and LAD autoantibodies preferentially react with the processed ectodomains, indicating that the processing induces neoepitopes. However, the details of how neoepitopes develop have not been elucidated. Read More

    Midterm outcomes of intracranial aneurysms with bleb formation with densely coiling of the aneurismal neck or entire aneurysm.
    Medicine (Baltimore) 2017 Aug;96(33):e7046
    aDepartment of Interventional Radiology, Jing'an District Centre Hospital of Shanghai, Huashan Hospital Fudan University Jing'an Branch bDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
    To evaluate whether the efficacy and safety of embolization of the aneurysmal neck were better than those of embolization of the entire aneurysm. Previous studies found that embolization of the aneurysmal neck can be used for treating ruptured intracranial aneurysm with bleb formation.In all, 163 patients with ruptured aneurysms with bleb formation who underwent endovascular embolization at the Shanghai Municipal Jing'an District Central Hospital from January 2014 to August 2015 were divided into the embolization of aneurysmal neck group (neck group; 87 cases) and embolization of entire aneurysm group (aneurysm group; 76 cases). Read More

    Facial Erosive Pustular Dermatosis After Cosmetic Resurfacing.
    JAMA Dermatol 2017 Oct;153(10):1021-1025
    Department of Dermatology, University of Michigan Medical School, Ann Arbor.
    Importance: Erosive pustular dermatosis (EPD) is a rare condition that typically affects actinically damaged skin of the scalp. Characterized by sterile pustules, erosions, and crusts, EPD is difficult to treat and heals slowly. The exact cause of EPD is unknown, although trauma is an inciting factor. Read More

    Inflammatory Dermatopathology for General Surgical Pathologists.
    Clin Lab Med 2017 Sep;37(3):673-696
    Department of Pathology, University of Michigan, 1301 Catherine Street, Medical Science I, M3261, Ann Arbor, MI 48109, USA; Department of Dermatology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:
    Owing to the wide variety and complexity of inflammatory skin diseases, inflammatory dermatopathology can be a challenging topic for dermatopathologists and general surgical pathologists alike. Following a basic tissue reaction pattern approach, this article reviews the most common and important entities of each pattern, with emphasis on differential diagnosis, diagnostic pitfalls, and appropriate workup when indicated. A few dermatologic emergencies are also discussed. Read More

    Refractory pemphigus foliaceus associated with herpesvirus infection: case report.
    Rev Inst Med Trop Sao Paulo 2017 3;59:e41. Epub 2017 Aug 3.
    Universidade Federal do Rio de Janeiro, Hospital Universitário Clementino Fraga Filho, Laboratório de Virologia, Rio de Janeiro, Rio de JaneiroBrasil.
    Pemphigus foliaceus (PF) is an autoimmune disease characterized by blistering of the skin. Infections caused by members of the herpesviridae family have been suggested as a possible triggering factor for pemphigus vulgaris (PV), but not for PF. The present study aimed to investigate the presence of Human herpesvirus (types 1, 2, 3) in corticosteroid refractory skin lesions from a patient with PF, by a Polymerase chain reaction (PCR) assay. Read More

    [Study of a family with epidermolysis bullosa simplex resulting from a novel mutation of KRT14 gene].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Aug;34(4):504-508
    Institute of Reproduction and Stem Cell Engineering, Central South University, Changsha, Hunan 410078, China.
    Objective: To determine the molecular etiology for a Chinese pedigree affected with epidermolysis bullosa simplex (EBS).

    Methods: Target region sequencing using a hereditary epidermolysis bullosa capture array combined with Sanger sequencing and bioinformatics analysis were used. Mutation taster, PolyPhen-2, Provean, and SIFT software and NCBI online were employed to assess the pathogenicity and conservation of detected mutations. Read More

    Low-Dose Naltrexone Treatment of Familial Benign Pemphigus (Hailey-Hailey Disease).
    JAMA Dermatol 2017 Oct;153(10):1015-1017
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio.
    Importance: Familial benign pemphigus, or Hailey-Hailey disease (HHD), is a rare and debilitating genetic dermatosis characterized by chronic, recurrent vesicles, erosions, and maceration in flexural areas. Despite the reported therapeutic modalities, such as topical and systemic corticosteroids, systemic immunomodulators, topical and systemic retinoids, and laser, HHD can still be markedly difficult to control.

    Objective: To assess low-dose naltrexone hydrochloride in the treatment of recalcitrant HHD. Read More

    Treatment of Hailey-Hailey Disease With Low-Dose Naltrexone.
    JAMA Dermatol 2017 Oct;153(10):1018-1020
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia.
    Importance: Hailey-Hailey disease is a severe genetic blistering disease of intertriginous skin locations that can lead to poor quality of life and increased morbidities. Multiple therapies are available with inconsistent outcomes and potentially severe adverse effects.

    Objective: To determine whether low-dose naltrexone is an effective treatment for Hailey-Hailey disease. Read More

    Non-dysbaric arterial gas embolism associated with chronic necrotizing pneumonia, bullae and coughing: a case report.
    Undersea Hyperb Med 2017 Jan-Feb;44(1):73-77
    Professor of Anesthesiology, Hyperbaric Division, Department of Anesthesiology, Duke University Medical Center, Durham, N.C. U.S.
    Arterial gas embolism (AGE) can be clinically devastating, and is most often associated with exposure to changes in ambient pressure, medical procedure or congenital malformation. Here we report a case of AGE in a 78-year-old male without these traditional risk factors. Rather, the patient's history included chronic obstructive pulmonary disease, necrotizing pneumonia, bullous disease and coughing. Read More

    Pemphigus foliaceus as a differential diagnosis in vesicobullous lesions.
    Einstein (Sao Paulo) 2017 Apr-Jun;15(2):220-222
    Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil.
    Given the challenge of clinical diagnosis of bullous skin lesions, this report aimed to discuss the histological changes, the presentation and clinical reasoning for diagnosis of these lesions. At the same time, the importance of the pathology was reviewed to identify these clinical scenarios. In this case report, we highlighted the clinical progression of a case of pemphigus foliaceus. Read More

    Treatment of ruptured blood blister aneurysms using primary flow-diverter stenting with considerations for adjunctive coiling: A single-centre experience and literature review.
    Interv Neuroradiol 2017 Oct 31;23(5):465-476. Epub 2017 Jul 31.
    Department of Neurointerventions, National Institute of Neurosciences, Budapest, Hungary.
    Objective The objective of this article is to conduct a single-centre evaluation and quick literature review of the effectiveness of primary flow-diverter (FD) treatment of ruptured blood blister aneurysms (BBAs), with additional relevance of adjunctive coiling. Methods Patients presenting with subarachnoid haemorrhage (SAH) due to ruptured BBAs and subsequently treated with FDs were retrospectively selected from June 2010 to January 2017. Treatment techniques, angiographic data on occlusion rates and procedural success as well as clinical outcomes using the modified Rankin Scale (mRS) were collated. Read More

    Pro-Inflammatory Chemokines and Cytokines Dominate the Blister Fluid Molecular Signature in Patients with Epidermolysis Bullosa and Affect Leukocyte and Stem Cell Migration.
    J Invest Dermatol 2017 Nov 20;137(11):2298-2308. Epub 2017 Jul 20.
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:
    Hereditary epidermolysis bullosa (EB) is associated with skin blistering and the development of chronic nonhealing wounds. Although clinical studies have shown that cell-based therapies improve wound healing, the recruitment of therapeutic cells to blistering skin and to more advanced skin lesions remains a challenge. Here, we analyzed cytokines and chemokines in blister fluids of patients affected by dystrophic, junctional, and simplex EB. Read More

    A Review of the Active Treatments for Toxic Epidermal Necrolysis.
    J Nippon Med Sch 2017 ;84(3):110-117
    Department of Dermatology, Nippon Medical School.
    Toxic epidermal necrolysis (TEN) is a severe adverse drug reaction associated with the separation of skin and mucous membranes at the dermal-epidermal junction. Although it is rare, many treatments have been trialed because of its high mortality rate. Active interventions performed to date include the use of systemic corticosteroids, intravenous immunoglobulins (IVIg), cyclosporine, plasmapheresis, anti-tumor necrosis factor drugs and N-acetylcysteine, but none has been established as the most effective therapy. Read More

    Drug management of neutrophilic dermatoses.
    Expert Rev Clin Pharmacol 2017 Oct 27;10(10):1119-1128. Epub 2017 Jul 27.
    b UOC Dermatologia, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti , Università Degli Studi di Milano , Milan , Italy.
    Introduction: Neutrophilic dermatoses are a heterogenous group of chronic, cutaneous inflammatory conditions characterized by the accumulation of neutrophils in the skin and by systemic inflammation. Neutrophilic dermatoses can be idiopathic or associated with other inflammatory or systemic diseases, including the group of the hereditary, autoinflammatory syndromes. Clinical management is challenging, due to limited clinical evidence and lack of clinical practice guidelines. Read More

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