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Gynecol Oncol Rep 2021 Aug 1;37:100800. Epub 2021 Jun 1.

University of Cincinnati, 234 Goodman Street, Cincinnati, OH 45219, United States.

Background: Prior pelvic radiation increases risks of pregnancy complications that can be life threatening. No documented pregnancy has successfully occurred with pelvic radiation dosing of >45 Gy. This case report describes a successful conception after receiving 54 Gy with subsequent severe pregnancy complications. Read More

J Matern Fetal Neonatal Med 2021 May 20:1-7. Epub 2021 May 20.

Department of Gynecology and Obstetrics, Kyoto University, Kyoto, Japan.

Aim: The pathogenic mechanism of chronic abruption-oligohydramnios sequence (CAOS) remains unknown, and there are no objective standards for diagnosis on imaging or using pathological evidence. We aimed to reconsider and clarify the true pathology of CAOS by integrating clinical, magnetic resonance imaging (MRI) and histopathological findings of the placenta.

Material And Methods: This is a case series of patients with CAOS managed at our hospital between 2010 and 2020. Read More

J Obstet Gynaecol Can 2021 Apr 25;43(4):463-468. Epub 2020 Aug 25.

Department of Obstetrics and Gynecology, Jewish General Hospital, McGill University, Montréal, QC; Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montréal, QC. Electronic address:

Objective: Early subchorionic hemorrhage may lead to a disruption in the placental-uterine matrix, which may result in an adherence of the placenta to the endometrium. We evaluated the effect of a first-trimester bleed on the need for a post-vaginal delivery dilatation and curettage (D&C) for removal of retained placenta.

Methods: We conducted a case-control study at a tertiary care centre between 2012 and 2016. Read More

Fetal Pediatr Pathol 2020 Oct 24:1-7. Epub 2020 Oct 24.

Unit of Obstetrics & Gynecology, Azienda USL - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Background: Large subchorionic cysts usually arise close to the placental cord insertion site (PCIS) inducing traction on the umbilical cord, impairing blood flow and favoring fetal growth restriction (FGR). Intracystic hemorrhage/hematoma is likely due to the prothrombotic properties of X cells secretion (extravillous trophoblast), which line the cyst wall. We describe a large subchorionic cyst located exactly at the PCIS, displacing the umbilical cord vessel branches running along the cyst surface. Read More

Fertil Steril 2020 09 3;114(3):509-510. Epub 2020 Aug 3.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Zhonghua Bing Li Xue Za Zhi 2020 Aug;49(8):782-787

Department of Pathology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.

Placental pathology reflects the health condition of both mother and fetus during pregnancy, providing information about pathogenesis especially in adverse pregnancies, and may provide guidance on subsequent pregnancies. Description on the placental changes after long-term use of rivanol is lacking, and this evaluated the placental changes, with emphasis on the differential diagnosis from other primary placental lesions. A total of 85 placentas from rivanol induced abortion submitted to the Department of Pathology, Obstetrics and Gynecology Hospital of Fudan University from Januaury 2017 to October 2019 were reviewed; and 81 gestational-age-matched cases of spontaneous abortion or preterm delivery during the same period were also included as the control group. Read More

Fertil Steril 2020 09 22;114(3):595-600. Epub 2020 Jul 22.

New York University Langone Prelude Fertility Center, New York, New York.

Objective: To study the effect of frozen embryo transfer (FET) preparation protocol on incidence of subchorionic hematoma (SCH) and serum hormone levels.

Design: Retrospective cohort study.

Setting: University-affiliated fertility center. Read More

Medicine (Baltimore) 2020 May;99(22):e20280

Department of Gynecology and Obstetrics, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital.

Introduction: Subchorionic hematoma (SCH) is a rare type of intrauterine hematoma, usually with limited impact on fetuses and pregnant women. But massive hematoma causes significant space occupying effect, affects blood supply of the fetus and finally may lead to fetus demise.

Patient Concerns: In this case report, we reported a 22-year-old pregnant woman presented to our hospital with complaint of irregular lower abdominal pain. Read More

J Cardiol Cases 2020 Apr 30;21(4):161-163. Epub 2019 Dec 30.

Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Owing to new surgical procedures and medications, more women who have undergone the Fontan procedure reach childbearing ages. We report five cases of pregnancy with Fontan circulation. Case 1 had subchorionic hematoma (SCH), fetal growth restriction (FGR), and preterm labor (PTL). Read More

Res Pract Thromb Haemost 2020 Feb 22;4(2):343-346. Epub 2020 Jan 22.

Department of Hematology Radboud Universisty Medical Center Nijmegen The Netherlands.

Congenital afibrinogenemia is a rare autosomal recessive disorder associated with an increased risk of hemorrhage, thrombosis, and obstetric complications. This case series of 4 pregnancies in 2 related patients seeks to address the key clinical question of the necessary doses of fibrinogen concentrate during pregnancy and puerperium. One pregnancy without the prophylactic use of fibrinogen concentrate resulted in spontaneous abortion. Read More

J Assist Reprod Genet 2020 Feb 6;37(2):305-309. Epub 2020 Jan 6.

Austin Fertility and Reproductive Medicine/Westlake IVF, 300 Beardsley Lane, Bldg B, Suite 200, Austin, TX, 78746, USA.

Purpose: To determine if certain clinical and/or embryologic factors are independently associated with the increased prevalence of subchorionic hematoma (SCH) among pregnancies achieved via in vitro fertilization (IVF) with fresh embryo transfer (ET).

Design: Retrospective chart review.

Methods: In this retrospective study, data were abstracted from 210 autologous oocyte IVF clinical pregnancies that resulted from fresh ET at a single fertility center from January 2012 through December 2016. Read More

Ginekol Pol 2019 ;90(11):656-661

Depertment of Gynecology and Obstetrics, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Objectives: To determine the clinical differences and factors affecting early pregnancy outcome in the first and early secondtrimester subchorionic hematoma cases.

Material And Methods: This study involved with the retrospective analysis and evaluation of 81 cases diagnosed withsubchorionic hematoma. The patients were grouped according to the gestational periods, symptoms at the time of admission,ratio of surrounding hematoma to the gestational sac, and whether there was a pregnancy loss. Read More

Zhongguo Zhen Jiu 2019 Oct;39(10):1046-50

Department of Acupuncture and Moxibustion, Shenzhen TCM Hospital, Shenzhen 518033, Guangdong Province.

Objective: To evaluate the therapeutic effect of auricular acupuncture combined with dydrogesterone for threatened abortion in early pregnancy complicated with subchorionic hematoma.

Methods: A total of 80 patients were randomized into an observation group and a control group, 40 cases in each one. In the control group, dydrogesterone was taken orally twice a day, 10 mg a time until 12-week into pregnancy. Read More

Obstet Gynecol 2019 10;134(4):863-868

Icahn School of Medicine at Mount Sinai, New York, Touro College of Osteopathic Medicine, Harlem, and Maternal Fetal Medicine Associates, PLLC, New York, New York.

Objective: To assess the association of first-trimester subchorionic hematomas with pregnancy outcomes after 20 weeks of gestation in women with singleton pregnancies.

Methods: We conducted a retrospective cohort study of all women with singleton pregnancies presenting for prenatal care before 14 weeks of gestation over a 3-year period at a single obstetric practice. All patients underwent routine first-trimester ultrasound examinations. Read More

Obstet Gynecol 2019 08;134(2):276-281

Icahn School of Medicine at Mount Sinai, New York, Touro College of Osteopathic Medicine, Harlem, and Maternal Fetal Medicine Associates, PLLC, New York, New York.

Objective: To assess the association of a first-trimester subchorionic hematoma with pregnancy loss in women with singleton pregnancies.

Methods: We conducted a retrospective cohort study of all women with singleton pregnancies presenting for prenatal care before 14 weeks of gestation over a 3-year period at a single obstetric practice. All patients had routine first-trimester ultrasound scans. Read More

Emerg Radiol 2019 Feb 29;26(1):87-97. Epub 2018 Aug 29.

Department of Radiology, University of Washington Medical Center, 1959 NE pacific St., Seattle, WA, 98195, USA.

Placental and periplacental bleeding are common etiologies for antepartum bleeding. Placental abruption complicates approximately 1% of pregnancies and is associated with increased maternal, fetal, and neonatal morbidity and mortality. This article reviews the normal placental appearance on ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) and then discusses the different morphological appearance of placental and periplacental hematomas along with their mimics. Read More

Int J Gynaecol Obstet 2018 06 13;141(3):391-392. Epub 2018 Mar 13.

Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

J Ultrasound Med 2018 Jul 17;37(7):1725-1732. Epub 2018 Jan 17.

Departments of Radiology, Obstetrics and Gynecology , Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Objectives: To evaluate and compare grading systems of subchorionic hematoma (SCH) on first-trimester ultrasound examinations with live embryos to assess which best correlates with early pregnancy outcome and to assess the effect of gestational age at the time of diagnosis on outcome.

Methods: First-trimester live singleton pregnancies between 6 and 11 weeks' gestational age with SCH were identified by an institutional database search. First-trimester outcome was categorized as "live" or "demise" based on ultrasound or medical record documentation. Read More

Pediatr Dev Pathol 2017 Sep-Oct;20(5):387-393. Epub 2017 Mar 20.

2 Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Background The pathology that underlies morbidly adherent placenta (MAP) is poorly understood. The objective of this study was to describe the placental pathology, especially implantation site pathology, associated with MAP. Methods This was a single institution, retrospective case-control study design examining placentas of patients who delivered between January 2008 and September 2013. Read More

J Matern Fetal Neonatal Med 2018 Jul 19;31(13):1715-1719. Epub 2017 May 19.

d Department of Obstetrics and Gynecology , İzmir Tepecik Training and Research Hospital , İzmir , Turkey.

Purpose: To investigate the relationships of TNF-related weak inducer of apoptosis (sTWEAK), a cytokine related to the TNF superfamily, its newly described soluble receptor sCD163, and the sTWEAK/sCD163 ratio with perinatal outcomes in women with first-trimester vaginal bleeding.

Materials And Methods: Seventy (41 threatened abortion and 29 control) gestational-age-matched (6-14 weeks) pregnant women were included in the study. Antenatal complications (gestational diabetes, preeclampsia, intrauterine growth restriction, oligohydramniosis, polyhydramniosis), and perinatal outcomes (delivery mode, birth weight, delivery week) were recorded. Read More

J Obstet Gynaecol Res 2016 Dec 20;42(12):1652-1656. Epub 2016 Sep 20.

Department of Obstetrics, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan.

Aim: To investigate the association between uterine bleeding preceding fetoscopic laser photocoagulation (FLP) and the presence of discolored amniotic fluid that impedes FLP.

Methods: A retrospective review of all multiple gestations requiring FLP at the present institution was conducted. The rate of low visibility because of discolored amniotic fluid at the beginning of FLP was compared between patients with and without a history of uterine bleeding, defined as either genital bleeding or ultrasonographically detected subchorionic hematoma. Read More

Zhonghua Yi Xue Za Zhi 2016 May;96(17):1383-5

Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200090, China.

Objective: To study the effects of subchorionic hematoma (SCH) on pregnancy outcome.

Methods: We searched publications from January 2000 to July 2015 for cohort and case-control studies evaluating subchorionic hematoma and perinatal outcomes, including spontaneous abortion, premature delivery and delivery mode.

Results: Data of 6 articles analyzed by meta-analysis showed that SCH group had higher rate of spontaneous abortion, while no difference in premature delivery and delivery mode, compared with threatened abortion group. Read More

Eur Rev Med Pharmacol Sci 2016 04;20(8):1656-63

Department of Chemistry and Pharmaceutical Technologies, University of Ferrara, Ferrara, Italy.

Objective: Alpha Lipoic Acid (ALA) is a safe natural molecule that exerts a selective immunomodulating activity with antioxidant and anti-inflammatory properties. This randomized controlled clinical trial (RCT) tested the effect of the vaginal administration with ALA or Progesterone, in subchorionic hematoma resorption in women with threatened miscarriage.

Patients And Methods: 400 mg of vaginal Progesterone or 10 mg of vaginal ALA were administered to sixty-two pregnant women, in the first trimester of gestation with threatened miscarriage and subchorionic hematoma. Read More

Fertil Steril 2016 07 7;106(1):140-143. Epub 2016 Apr 7.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Objective: To examine the association between first-trimester bleeding and live-birth rates in twin pregnancies conceived with in vitro fertilization (IVF).

Design: Retrospective cohort study.

Setting: Academic infertility practice. Read More

J Clin Endocrinol Metab 2016 06 6;101(6):2612-21. Epub 2016 Apr 6.

The Cecil H. and Ida Green Center for Reproductive Biology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032.

Context: Nrf2 is a key transcription factor that modulates cell defense mechanisms against endogenous and exogenous stress. Previously, we reported that thrombin increased matrix metalloproteinases and prostaglandin synthesis in human amnion mesenchymal cells.

Objective: We sought to determine whether activation of Nrf2 alters the effect of thrombin on prostaglandin synthesis, protease activation, and cytokine release in human amnion. Read More

J Matern Fetal Neonatal Med 2017 Feb 28;30(4):406-410. Epub 2016 Apr 28.

a Reproductive Medicine Center, Department of Obstetrics and Gynecology, Drum Tower Hospital Affiliated to Nanjing University Medical College , Nanjing , Jiangsu , PR China.

Objective: The aim of this retrospective cohort study was to assess the effect of subchorionic hematoma (SCH) on pregnancy outcomes in IVF/ICSI patients.

Methods: We retrospectively analyzed 1097 pregnancies achieved by in vitro fertilization and embryo transfer (IVF-ET) or frozen-thawed embryo transfers (FETs) between January 2013 and June 2013 at the IVF center of Nanjing Drum Tower Hospital. The prevalence of SCH was 12. Read More

Rinsho Ketsueki 2016 Jan;57(1):31-5

Department of Obstetrics and Gynecology, Japan Baptist Hospital.

Blood coagulation factors play an essential role in pregnancy. We describe a 30-year-old pregnant woman whose course was complicated by dysfibrinogenemia with polymorphism of fibrinogen AαThr312Ala (rs6050) GG genotype. She was admitted to our hospital for genital bleeding and a huge subchorionic hematoma at 6 gestational weeks. Read More

Fertil Steril 2016 05 25;105(5):1241-1246. Epub 2016 Jan 25.

Department of Obstetrics and Gynecology, Fertility Associates of Memphis, Vanderbilt University, Memphis, Tennessee.

Objective: To determine the frequency of subchorionic hematomas (SCH) in first-trimester ultrasound examinations of patients with infertility and recurrent pregnancy loss (RPL) and in patients from a general obstetric population. To determine if the method of assisted reproduction utilized or the use of anticoagulants, such as heparin and aspirin (ASA), influenced frequency of SCH.

Design: Prospective, cohort study. Read More

Emerg Radiol 2016 Apr 19;23(2):105-9. Epub 2015 Nov 19.

Department of Radiology, University of California, San Diego Medical Center, 200 West Arbor Drive, San Diego, CA, 92103, USA.

The pregnant abdominal trauma patient presents a unique diagnostic challenge. This study aimed to evaluate the accuracy of abdominal sonography for the detection of clinically important injuries in pregnant abdominal trauma patients. A retrospective review was performed of a trauma center database from 2001 to 2011. Read More