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Clin Chim Acta 2022 Jun 22. Epub 2022 Jun 22.

Department of Neurosurgery, Hangzhou Ninth People's Hospital, 98 Yilong Road, Hangzhou 311225, Zhejiang Province, China. Electronic address:

Background: Growth-arrest-specific protein 6 (Gas6) exerts nervous protective effects on acute brain injury. We endeavored to ascertain whether serum Gas6 concentrations are associated with severity, delayed cerebral ischemia (DCI) and prognosis following aneurysmal subarachnoid hemorrhage (aSAH).

Methods: We measured serum Gas6 concentrations of 124 aSAH patients. Read More

Neurocrit Care 2022 Jun 25. Epub 2022 Jun 25.

Department of Intensive Care Medicine, Amsterdam University Medical Centre, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands.

Background: Aneurysmal subarachnoid hemorrhage (aSAH) is an important indication for intensive care unit admission and may lead to significant morbidity and mortality. We assessed the ability of C-terminal proarginine vasopressin (CT-proAVP) to predict disease outcome, mortality, and delayed cerebral ischemia (DCI) in critically ill patients with aSAH compared with the World Federation of Neurological Surgeons (WFNS) score and Acute Physiological and Chronic Health Evaluation IV (APACHE IV) model.

Methods: C-terminal proarginine vasopressin was collected on admission in this single-center, prospective, observational cohort study. Read More

Neurocrit Care 2022 Jun 25. Epub 2022 Jun 25.

Department of Neurology, Columbia University, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.

Background: Prolonged external ventricular drainage (EVD) in patients with subarachnoid hemorrhage (SAH) leads to morbidity, whereas early removal can have untoward effects related to recurrent hydrocephalus. A metric to help determine the optimal time for EVD removal or ventriculoperitoneal shunt (VPS) placement would be beneficial in preventing the prolonged, unnecessary use of EVD. This study aimed to identify whether dynamics of cerebrospinal fluid (CSF) biometrics can temporally predict VPS dependency after SAH. Read More

Clin Neurol Neurosurg 2022 May 31;219:107317. Epub 2022 May 31.

Department of Neurosurgery, First Affiliated Hospital of Medical University, Harbin, PR China. Electronic address:

Objective: As a chronic complication of aneurysmal subarachnoid hemorrhage(aSAH), Shunt dependent hydrocephalus (SDHC) often leads to severe neurological deficits. At present, risk factors of SDHC after aSAH are being refined. So this study aims to investigate independent risk factors and develop a novel score to identify early the patients who require a permanent shunt. Read More

PLoS One 2022 24;17(6):e0270410. Epub 2022 Jun 24.

Department of Neurosurgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Subarachnoid hemorrhage (SAH) is a common disease with high morbidity and mortality, which can cause pathological, physiological, and biological reactions. SAH causes a series of responses such as neuronal and cerebral cortex damage, which in turn leads to inflammation and apoptosis. Traditional Chinese medicine has a strong anti-inflammatory effect, such as Alantolactone (ATL). Read More

Transl Stroke Res 2022 Jun 24. Epub 2022 Jun 24.

Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd, Chongqing, 400016, People's Republic of China.

Delayed cerebral ischemia (DCI) is the most severe complication after subarachnoid hemorrhage (SAH), and cortical spreading depolarization (CSD) is believed to play a vital role in it. However, the dynamic changes in cerebral blood flow (CBF) in response to CSD in typical SAH models have not been well investigated. Here, SAH was established in mice with endovascular perforation. Read More

Acta Neurochir (Wien) 2022 Jun 24. Epub 2022 Jun 24.

Department of Clinical Sciences - Neurosciences, Umeå University, 901 87, Umeå, Sweden.

Background: Early, objective prognostication after aneurysmal subarachnoid haemorrhage (aSAH) is difficult. A biochemical marker would be desirable. Correlation has been found between levels of the protein S100 beta (S100B) and outcome after aSAH. Read More

Br J Neurosurg 2022 Jun 24:1-4. Epub 2022 Jun 24.

Department of Neurosurgery, Oita University Faculty of Medicine, Oita, Japan.

-induced mycotic aneurysm is difficult to treat and often has poor outcomes with severe symptom progression. Early diagnosis is also difficult, and blood and cerebrospinal fluid tests often fail to reveal any findings. A 74-year-old man presented with recurrent nosebleeds in addition to symptoms of left optic neuritis. Read More

Neurol Clin Pract 2022 Jun;12(3):e25-e27

Department of Neurology, University of Tennessee Health Science Center, Memphis, TN.

Objective: COVID-19 infection is suggested as one of the causes for hydrocephalus (HCP) of unknown etiology. COVID-19 infection may present with a range of neurologic symptoms given viral neurotropic and neuroinvasive properties. Postinfectious HCP is a severe complication as a potential sequela of COVID-19 infection. Read More

Pathogens 2022 May 24;11(6). Epub 2022 May 24.

Department of Neurosurgery, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, Germany.

Background: SARS-CoV virus infection results in a dysbalanced and severe inflammatory response with hypercytokinemia and immunodepression. Viral infection triggers systemic inflammation and the virus itself can potentially cause vascular damage, including blood-brain barrier (BBB) disruption and alterations in the coagulation system, which may result in cardiovascular and neurovascular events. Here, we review the literature and present a case of COVID-19 infection leading to an aneurysmal subarachnoid haemorrhage (aSAH). Read More

J Clin Med 2022 Jun 16;11(12). Epub 2022 Jun 16.

Department of Diagnostic and Interventional Neuroradiology, Hospital Bremen-Mitte, 28205 Bremen, Germany.

Previous case series have described the safety and efficacy of different stent models for stent-assisted aneurysm coiling (SAC), but comparative analyses of procedural results are limited. This study investigates the procedural outcome and safety of three different stent models (Atlas™, LEO+™ (Baby) and Enterprise™) in the setting of elective SAC treated at a tertiary neuro-endovascular center. We retrospectively reviewed all consecutively treated patients that received endovascular SAC for intracranial aneurysms between 1 July 2013 and 31 March 2020, excluding all emergency angiographies for acute subarachnoid hemorrhage. Read More

J Clin Med 2022 Jun 14;11(12). Epub 2022 Jun 14.

Department of Neurosurgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China.

Early brain injury is considered to be a primary reason for the poor prognosis of patients suffering from subarachnoid hemorrhage (SAH). Due to its pro-inflammatory activity, cold-inducible RNA-binding protein (CIRP) has been implicated in the ischemic brain insult, but its possible interplay with hypothermia in SAH treatment remains to be evaluated. One-hundred and thirty-eight Sprague-Dawley rats (300-350 g males) were randomly allocated into the following groups: sham-operated (Sham); SAH; and SAH + hypothermia (SAH + H), each comprised of 46 animals. Read More

Brain Sci 2022 Jun 4;12(6). Epub 2022 Jun 4.

Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350004, China.

Objective: In this study, we assessed the correlation between the lactate dehydrogenase (LDH) to phosphate ratio and the prognosis of microsurgical clippings for ruptured intracranial aneurysm (rIA) to test the hypothesis that the serum LDH to phosphate ratio could be a predictor of the outcome of microsurgical clipping for rIA.

Methods: Records of rIA patients between 2012 and 2018 were retrospectively collected. Age, sex, Hunt-Hess grade, Fisher grade, medical history, aneurysm location, hydrocephalus, laboratory data including serum LDH, phosphate, and LDH to phosphate ratio, related complications, and the outcomes in 3 months were recorded. Read More

J Med Case Rep 2022 Jun 23;16(1):265. Epub 2022 Jun 23.

Department of Rehabilitation, Nagoya City Midori Municipal Hospital, 1-77, Shiomigaoka, Midori-ku, Nagoya-shi, Aichi, 458-0037, Japan.

Background: Pulmonary complications can be caused by intraoperative mechanical ventilation. In particular, prolonged mechanical ventilation is associated with a high mortality rate, a risk of pulmonary complications, prolonged hospitalization, and an unfavorable discharge destination. Pre- and postoperative rehabilitation are important for the resolution of pulmonary complications in acute cases. Read More

J Clin Hypertens (Greenwich) 2022 Jun 23. Epub 2022 Jun 23.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Controlling blood pressure levels is critical to preventing intracranial aneurysm rupture, and a summary review of induced rupture events allows better health education for patients. We retrospectively reviewed all medical records of consecutive patients with aneurysmal subarachnoid hemorrhage (aSAH) admitted to Beijing Tiantan Hospital from 2015 to 2020. We collected patients' demographic information, aneurysm morphology, blood pressure level on admission, time to onset, and events at the time of aneurysm rupture to analyze the factors precipitating aneurysmal rupture. Read More

Neurosurg Rev 2022 Jun 23. Epub 2022 Jun 23.

Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Recurrent aneurysms are a major cause of re-aneurysmal subarachnoid hemorrhage (aSAH), but information on long-term clip durability and predictors is insufficient. This study aimed to present the incidence rate of > 10 years and investigate predictors of a recurrent aneurysm in aSAH survivors. We included 1601 patients admitted with aSAH and treated by microsurgical clipping between January 1993 and May 2010. Read More

World Neurosurg 2022 Jun 20. Epub 2022 Jun 20.

Department of Neurosurgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. Electronic address:

Objective: Diagnosis and management of aneurysmal subarachnoid hemorrhage (aSAH) depends heavily on imaging modalities that repeatedly expose patients to ionizing radiation. There is limited literature on cumulative radiation exposure in this patient population, which is a problem compounded by wide variation between institutions. The present study quantifies the cumulative cranial exposure to ionizing radiation resulting from diagnostic medical imaging and medical procedures during initial hospitalization for ruptured aneurysmal subarachnoid hemorrhage at a single academic institution and estimates the risk of future adverse events related to radiation injury. Read More

Exp Neurol 2022 Jun 20:114151. Epub 2022 Jun 20.

Department of Neurosurgery Intensive Care Unit, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, PR China. Electronic address:

Background: New data are accumulating on the effects of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in cerebrovascular diseases. We explored the potential role of KLF3-AS1-containing bone marrow MSC-EVs (BMSC-EVs) in a rat model of subarachnoid hemorrhage (SAH).

Methods: A rat model of SAH was established by endovascular perforation method, into which KLF3-AS1-containing EVs from BMSCs or miR-183-5p mimic were injected. Read More

J Ophthalmic Inflamm Infect 2022 Jun 23;12(1):20. Epub 2022 Jun 23.

Ophthalmology Department, Medical University Pleven, 91 Vladimir Vazov str, Pleven, Bulgaria.

Background: The aim of this report is to describe ocular side effects in patients who received one of the two COVID-19 vaccines - Astra Zeneca or Pfizer-Biontech and to contribute to the common understanding of the COVID-19 vaccination process.

Results: Three patients reactivated underlying herpetic disease and developed uveitis and keratitis. Two of them were vaccinated with Pfizer and one was with Astra Zeneca. Read More

Tomography 2022 May 25;8(3):1429-1436. Epub 2022 May 25.

Academic Neurology Unit, Department of Medical-Surgical Sciences and Biotechnologies, Ospedale A. Fiorini, "Sapienza" University of Rome, 04019 Terracina, Italy.

The aim of this study was to identify early radiological signs of secondary hydrocephalus. We retrieved neuroradiological data from scans performed at various times in patients who underwent surgery for secondary hydrocephalus due to severe traumatic brain injury (TBI), subarachnoid haemorrhage (SAH), or brain tumour (BT). Baseline measurements, performed on the earliest images acquired after the neurological event (T0), included Evans' index, the distance between frontal horns, and the widths of both temporal horns. Read More

Neurol Int 2022 May 31;14(2):488-496. Epub 2022 May 31.

Neurology Department, NYU Langone Health, New York, NY 10017, USA.

(1) Background: Reversible cerebral vasoconstriction syndrome (RCVS) encompasses a clinical and radiological diagnosis characterized by recurrent thunderclap headache, with or without focal deficits due to multifocal arterial vasoconstriction and dilation. RCVS can be correlated to pregnancy and exposure to certain drugs. Currently, the data on prevalence of RCVS in the postpartum period is lacking. Read More

Stroke 2022 Jun 23:101161STROKEAHA121038659. Epub 2022 Jun 23.

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden. (T.J., W.E.E., T.K., A.J.).

Background: Millions of women worldwide use exogenous hormones as oral contraceptives or hormone replacement therapy. Still, time-dependent and long-term consequences of exogenous hormones on stroke risk remains unclear.

Methods: We examined the association between self-reported oral contraceptive and hormone replacement therapy use and stroke risk in 257 194 women from the UK Biobank, born between 1939 and 1970. Read More

J Neurosurg Case Lessons 2022 May 30;3(22):CASE22113. Epub 2022 May 30.

Departments of Neurosurgery and.

Background: Cerebral vasospasm after aneurysmal subarachnoid hemorrhage can lead to considerable mortality and morbidity affecting the intracranial vessels, leading to delayed cerebral ischemia and stroke. Therapeutic options for patients with treatment-refractory vasospasm are limited, particularly in the setting of significant cardiopulmonary disease. Administration of nicardipine, a calcium channel blocker, into the intrathecal space may represent a potential treatment option for this population. Read More

J Neurosurg Case Lessons 2022 May 30;3(22):CASE21690. Epub 2022 May 30.

Department of Neurosurgery, Gifu University Hospital, Gifu, Japan.

Background: Perianeurysmal cysts in the brainstem after endovascular coil embolization are rare, and their underlying mechanism remains unclear. The authors reported a case of a postcoiling perianeurysmal cyst that developed 6 years after endovascular coil embolization for a ruptured aneurysm and reviewed the related literature.

Observations: A 77-year-old woman had a history of subarachnoid hemorrhage 6 years earlier. Read More

J Neurosurg Case Lessons 2022 Jun 6;3(23):CASE22100. Epub 2022 Jun 6.

Department of Neurosurgery, Tokushima University, Tokushima, Japan.

Background: Sufficient understanding of the angioarchitecture of an arteriovenous fistula (AVF) at the craniocervical junction (CCJ) is crucial to surgical treatment but is often difficult because of the complex vascular anatomy. Intraarterial indocyanine green (ICG) videoangiography has emerged as a more useful option for understanding the vascular anatomy than intravenous ICG videoangiography. This report describes two cases of CCJ AVFs successfully treated by surgery using intraarterial ICG videoangiography and describes the efficacy of this technique. Read More

Acta Neurochir (Wien) 2022 Jun 23. Epub 2022 Jun 23.

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.

Background: Aneurysmal subarachnoid hemorrhage (aSAH) patients admitted to primary stroke centers are often transferred to neurosurgical and endovascular services at tertiary centers. The effect on microsurgical outcomes of the resultant delay in treatment is unknown. We evaluated microsurgical aSAH treatment > 72 h after the ictus. Read More

J Neurointerv Surg 2022 Jun 22. Epub 2022 Jun 22.

Neurosurgery, Albany Medical Center, Albany, New York, USA

Background: Intracranial stent placement for the treatment of cerebral aneurysms is increasingly utilized in both ruptured and unruptured scenarios. Intravenous (IV) cangrelor is a relatively new antiplatelet agent that was initially approved for coronary interventions. In addition to our institution, five other centers have published their results using IV cangrelor in neurointerventional procedures. Read More

Neurointervention 2022 Jun 23. Epub 2022 Jun 23.

Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: To analyze trends in mortality rates from hemorrhagic stroke (HS) according to HS subtypes, using nationwide data from January 2012 to December 2020.

Materials And Methods: We used data from the National Health Claims Database provided by the National Health Insurance Service for 2012-2020 using the International Classification of Disease. The age-adjusted mortality rates of HS, which included subarachnoid hemorrhage (SAH) and intracerebral hemorrhage (ICH), were calculated, and additional analyses were conducted according to age and sex. Read More

Stroke 2022 Jun 22:101161STROKEAHA122038951. Epub 2022 Jun 22.

Department of Neurology and Neurosurgery, Division of Neurocritical Care, Emory University School of Medicine, Atlanta, GA. (F.A., O.T., O.S.).

J Neurol 2022 Jun 22. Epub 2022 Jun 22.

Department of Neurosurgery, Klinikum Rechts Der Isar, Technical University Munich, Ismaningerstrasse 22, 81675, Munich, Germany.

Background: Aneurysm treatment during cerebral vasospasm (CVS) phase is frequently considered as particularly dangerous, mainly because of the risk of cerebral infarct.

Objective: We aimed to evaluate the risk of aneurysmal subarachnoid haemorrhage (aSAH)-specific complications and functional outcome in patients treated during CVS phase.

Methods: We retrospectively analysed a large, retro- and prospectively collected database of aSAH patients admitted to our department between March 2006 and March 2020. Read More