Search Our Scientific Publications & Authors

World Neurosurg 2019 Feb 16. Epub 2019 Feb 16.

Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China. Electronic address:

Background: Shunt-dependent hydrocephalus (SDH) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and affect its outcome significantly. Whether fenestration of the lamina terminalis (FLT) during anterior circulation aneurysm clipping for aSAH can decrease the occurrence of SDH is still controversial.

Methods: Ovid, Pubmed database were retrieved by the following keywords "hydrocephalus" "subarachnoid hemorrhage" "aneurysm" "fenestration" and "lamina terminalis". Read More

Exp Neurol 2019 Feb 16. Epub 2019 Feb 16.

Department of Physiology and Pharmacology, Loma Linda University, 11041 Campus St, Risley Hall, Room 219, Loma Linda, CA 92354, USA. Electronic address:

Background And Purpose: Mitochondrial dysfunction is involved in the mechanism of early brain injury (EBI) following subarachnoid hemorrhage (SAH). Blood-brain barrier disruption is a devastating outcome in the early stage of SAH. In this study, we aimed to investigate the role of a mitochondria-related drug Mitoquinone (MitoQ) in blood-brain barrier disruption after SAH in rats. Read More

Ugeskr Laeger 2019 Feb;181(7)

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In this case report, we present a 28-year-old woman who was admitted to a neuro-intensive care unit with sub-arachnoid haemorrhage. She was intubated and haemodynamically unstable. Over five days the need for norepinephrine reached the level of 1. Read More

Neuroradiol J 2019 Feb 19:1971400919829048. Epub 2019 Feb 19.

1 Department of Neuroradiology, Centro Hospitalar Lisboa Central, Lisbon, Portugal.

Background: Computed tomography (CT) perfusion has been studied as a tool to predict delayed cerebral ischemia (DCI) and clinical outcome in spontaneous subarachnoid hemorrhage (SAH). The purpose of the study was to determine whether quantitative CT perfusion performed within 72 hours after admission can predict the occurrence of DCI and clinical outcome as measured with a modified Rankin scale (mRS) at 3 months after ictus.

Methods: Cerebral perfusion was assessed in a prospective cohort of patients with acute SAH. Read More

Stroke 2019 Feb 19:STROKEAHA118023771. Epub 2019 Feb 19.

From the Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas. (V.S.B., T.Y.E.A., S.G.A., A.R.P., K.A.L., C.E., J.B., C.M.M., B.G.W., D.S., H.H.B., J.W.).

Background and Purpose- Predicting long-term functional outcomes after intracranial aneurysmal rupture can be challenging. We developed and validated a scoring system-the Southwestern Aneurysm Severity Index-that would predict functional outcomes at 1 year after clipping of ruptured aneurysms. Methods- Ruptured aneurysms treated microsurgically between 2000 and 2014 were included. Read More

Clin Neurol Neurosurg 2019 Feb 5;179:4-8. Epub 2019 Feb 5.

Department of Neurosurgery, The Second Hospital of Shandong University, Jinan 250033, Shandong, China. Electronic address:

Objective: This study aimed to investigate the efficacy of early management for poor-grade aneurysmal subarachnoid hemorrhage (aSAH; WFNS grade IV and V), and analyze the prognostic factors.

Patients And Methods: A total of 104 consecutive patients with poor-grade aSAH from the Department of Neurosurgery, the Second Hospital of Shandong University were enrolled between January 2010 and December 2017. All these patients underwent early microsurgical clipping or endovascular coiling within three days after onset. Read More

World Neurosurg 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, University of Missouri Hospital and Clinics, Columbia, Missouri, USA.

Background: Dantrolene has a safe side-effect profile and a mechanism of action that makes it attractive as an option for treatment of cerebral vasospasm. The authors report two cases of refractory cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage that were successfully treated with intra-arterial dantrolene.

Case Descriptions: Two patients, a 63-year-old woman and 36-year-old woman, developed severe vasospasm refractory to intra-arterial vasodilators after rupture of anterior communicating artery aneurysms. Read More

Circulation 2019 Feb 18. Epub 2019 Feb 18.

Endocrinology, VU Medical Centre, Netherlands.

In hypogonadal/postmenopausal individuals, hormone therapy has been associated with an increased risk for cardiovascular events (CVEs). A steeply growing population that often receives exogenous hormones is transgender individuals. Although transgender individuals hypothetically have an increased risk of CVEs, there is little known about the occurrence of CVEs in this population. Read More

Surg Neurol Int 2019 18;10. Epub 2019 Jan 18.

Department of Neurosurgery, Wakayama Rosai Hospital, Wakayama, Japan.

Background: Direct surgery is commonly selected for the treatment of cranio-cervical junction dural arteriovenous fistula and its outcome is more satisfactory than that of embolization. Intraoperative treatment evaluation is relatively easy in embolization, whereas in direct surgery it can be difficult.

Case Description: A 67-year-old male suffered a subarachnoid hemorrhage. Read More

Surg Neurol Int 2019 15;10. Epub 2019 Jan 15.

Department of Neurosurgery, Ube-kohsan Central Hospital, 750 Nishikiwa, Ube, Yamaguchi, Japan.

Background: We present a case of tentorial dural arteriovenous fistula (TDAVF) causing subarachnoid hemorrhage with mass effect of large venous pouches, which was struggling to diagnosis and management due to complex vasculature and severe general condition.

Case Description: A 43-year-old man was transferred to our hospital due to sudden consciousness disturbance. A neurological examination revealed tetraparesis and pupil dilatation with no light reflex. Read More

Clin Interv Aging 2019 23;14:203-207. Epub 2019 Jan 23.

Department of Neurosurgery, Inner Mongolia Xing'an Meng People's Hospital, Ulanhot 137400, China,

Objective: Intracranial aneurysm is a kind of severe intracranial disease mainly responsible for subarachnoid hemorrhage, and the rupture of intracranial aneurysm results in a mortality rate of 30%-40%. For the first time in the world, this study aimed to assess the feasibility and efficacy of enhanced recovery after surgery (ERAS) protocol in Chinese elderly patients with intracranial aneurysm.

Methods: In this study, 300 elderly patients with intracranial aneurysm were recruited and divided into two groups as follows: ERAS group (n=150, ERAS protocol) and control group (n=150, conventional management). Read More

J Clin Neurosci 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurosurgery, Jinling Hospital, School of Medicine, Southern Medical University (Guangzhou), 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China; Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China. Electronic address:

Early Brain Injury, rather than Cerebral Vasospasm, has been demonstrated to be more important for patients with Subarachnoid hemorrhage. It is considered that allicin can make sense in a wide range of pharmacological areas and can be taken as a therapeutic method in many pathologic situations. We have explored the potential effect of allicin and possible mechanisms in Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats. Read More

World Neurosurg 2019 Feb 14. Epub 2019 Feb 14.

Lyerly Neurosurgery / Baptist Health, Baptist Neurological Institute, Jacksonville, FL.

Background: Intracranial vascular infections of fungal etiology are extremely rare. The vast majority of cases occur in immunocompromised patients with invasive fungal disease, most commonly originating in the paranasal sinuses or the lungs. An extremely rare type in this part of the world, called Granulomatous Invasive Rhinosinusitis, has been reported to affect immunocompetent patients in most cases, and its causative strain has potential to invade the intracranial arteries. Read More

J Neurosurg 2019 Feb 15:1-2. Epub 2019 Feb 15.

Am J Emerg Med 2019 Feb 7. Epub 2019 Feb 7.

Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Dapi Rd., Niaosong Township, Kaohsiung County 833, Taiwan. Electronic address:

Background: Subarachnoid hemorrhage (SAH) is a serious cause of headaches. The Ottawa subarachnoid hemorrhage (OSAH) rule helps identify SAH in patients with acute nontraumatic headache with high sensitivity, but provides limited information for identifying other intracranial pathology (ICP).

Objectives: To assess the performance of the OSAH rule in emergency department (ED) headache patients and evaluate its impact on the diagnosis of intracranial hemorrhage (ICH) and other ICP. Read More

Ann Thorac Surg 2019 Feb 11. Epub 2019 Feb 11.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio; Department of Neurology, NYU School of Medicine, New York, NY. Electronic address:

Background: Little data exists regarding reversal and resumption of antithrombotics following left ventricular assist device (LVAD)-associated intracranial hemorrhage (ICH).

Methods: Prospectively collected data of LVAD patients with ICH was reviewed. Coagulopathy reversal agents, antithrombotic regimens and thrombotic (venous thromboembolism, ischemic stroke, myocardial infarction) and hemorrhagic (recurrent ICH, gastrointestinal bleed, anemia requiring transfusion) complications were recorded. Read More

Neural Regen Res 2019 Jun;14(6):1029-1036

Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, China.

The α5 subunit-containing gamma-amino butyric acid type A receptors (α5 GABAARs) are a distinct subpopulation that are specifically distributed in the mammalian hippocampus and also mediate tonic inhibitory currents in hippocampal neurons. These tonic currents can be enhanced by low-dose isoflurane, which is associated with learning and memory impairment. Inverse agonists of α5 GABAARs, such as L-655,708, are able to reverse the short-term memory deficit caused by low-dose isoflurane in young animals. Read More

Neural Regen Res 2019 Jun;14(6):1013-1024

Department of Neurosurgery, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China; Anhui Province Key Laboratory of Brain Function and Brain Disease, Hefei, Anhui Province, China.

The Wnt/Frizzled signaling pathway participates in many inflammation-linked diseases. However, the inflammatory response mediated by the Wnt/Frizzled signaling pathway in experimental subarachnoid hemorrhage has not been thoroughly investigated. Consequently, in this study, we examined the potential role of the Wnt/Frizzled signaling pathway in early brain injury in rat models of subarachnoid hemorrhage. Read More

J Rehabil Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, , Stockholm, Sweden.

Objective: To explore associations between pituitary dysfunction and clinical outcome at 12 months after traumatic brain injury and aneurysmal subarachnoid haemorrhage.

Methods: Prospective cohort study of 82 patients with traumatic brain injury and 45 with aneurysmal subarachnoid haemorrhage, included at 1 neurointensive care unit. Baseline data comprised age, sex, Glasgow Coma Scale (GCS) score, S100B and pupil light reactions. Read More

J Neurointerv Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, West Virginia University Hospital, Morgantown, West Virginia, USA.

A middle-aged patient presented with posterior circulation symptoms attributable to a large eccentric basilar trunk aneurysm. The planned treatment was flow diversion with loose coil packing which was successfully performed using a Pipeline Flex device deployed from the basilar to the left posterior cerebral artery. The complete procedure including live biplane fluoroscopy was digitally recorded. Read More

J Clin Med 2019 Feb 12;8(2). Epub 2019 Feb 12.

TENSOR-Team of NeuroSurgery-Oriented Reaserch, Jagiellonian University Medical College, 31-008 Kraków, Poland.

Tortuosity of blood vessels is a common angiographic finding that may indicate systemic disease and can be correlated with vascular pathologies. In this work, we determined whether patients with and without internal carotid artery (ICA) aneurysm presented with differences in its tortuosity descriptors. We retrospectively analysed data of 298 patients hospitalized between January 2014 and June 2018. Read More

Eur J Case Rep Intern Med 2018 28;5(8):000912. Epub 2018 Aug 28.

Vascular Neurology Department, Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico.

Background: Bilateral third cranial nerve palsy has only been reported in a handful of conditions including some with inflammatory, tumoural and vascular causes. An urgent imaging study is mandatory to rule out vascular aetiology, mainly aneurysmal subarachnoid haemorrhage (aSAH).

Case Presentation: A 28-year-old Hispanic woman presented to the emergency department with a 21-day history of a sudden-onset and severe headache that on three occasions was accompanied by transient loss of awareness, the last episode occurring a week previously. Read More

Eur J Case Rep Intern Med 2018 28;5(11):000961. Epub 2018 Nov 28.

Department of Internal Medicine, Centro Hospitalar do Meio Tejo, EPE, Tomar, Portugal.

Non-traumatic haematomyelia is a rare finding of acute onset, which in most cases is the result of arteriovenous malformations (AVM), tumours, coagulation disorders or autoimmune conditions, but may also be secondary to treatment with anticoagulants and radiotherapy. We present the case of a 58-year-old woman with sudden onset cervical pain, followed by asymmetric diminution of strength in the upper limbs with reduced pain sensitivity. The diagnosis of AVM at the C7 and D1 levels was made following cervico-dorsal magnetic resonance imaging and angiography. Read More

Oper Neurosurg (Hagerstown) 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurological Surgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania.

Background: The use of the pipeline embolization device (PED; Medtronic, Dublin, Ireland) in the posterior circulation has been limited and infrequently reported compared to other off-label utilizations. Posterior inferior cerebellar artery aneurysms (PICAA) constitute 1 of the least reported posterior circulation aneurysms treated with PED. No clinical studies have addressed the treatment of these aneurysms with flow diversion exclusively. Read More

J Vasc Interv Neurol 2018 Nov;10(2):62-64

Department of Neurology, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.

The TNF-α antagonists are the drugs used for the treatment of ulcerative colitis (UC). Nontraumatic convexity subarachnoid hemorrhage is an infrequent nonaneurysmal subtype of subarachnoid bleeding caused mainly by reversible cerebral vasoconstriction syndrome (RCVS), cerebral amyloid angiopathy, and posterior reversible encephalopathy syndrome (PRES). We present a 26-year-old female patient with a diagnosis of UC taking Adalimumab. Read More

J Vasc Interv Neurol 2018 Nov;10(2):33-40

Zeenat Qureshi Stroke Institute, St. Cloud, MN, USA.

Objective: To assess the effectiveness of cilostazol, a selective inhibitor of phosphodiesterase type III, in preventing cerebral ischemia related to cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH).

Methods: A total of six clinical studies met the inclusion criteria and were included in the meta-analysis. We calculated pooled risk ratios (RR) and 95% confidence intervals (CI) using random-effects models. Read More

J Vasc Interv Neurol 2018 Nov;10(2):28-32

Department of Neurosurgery, University of Patras, Patras, Greece.

Background: Hereditary multiple exostoses (HME) is an inherited genetic condition, characterized by the formation of multiple osteochondromas, developing throughout childhood and into puberty. Vascular complications associated with HME are uncommon.

Methods: A case of a patient with HME who was admitted to hospital with subarachnoid hemorrhage (SAH), as a result of acute rupture of a basilar tip aneurysm (BTA), will be presented. Read More

J Vasc Interv Neurol 2018 Nov;10(2):1-3

Department of Neurology and Neurological Intensive Care Unit, Hacettepe University Hospitals, Sihhiye, Ankara, Turkey.

Crit Care 2019 Feb 11;23(1):42. Epub 2019 Feb 11.

Department of Anaesthesiology and Critical Care Medicine, INT (Institut de Neurosciences de la Timone), University Hospital Timone, Aix Marseille University, Marseille, France.

Background: Several lipid metabolites in cerebrospinal fluid are correlated with poor outcomes in aneurysmal subarachnoid haemorrhage. Most of these metabolites bind to ubiquitous thromboxane-prostaglandin (TP) receptors, causing vasoconstriction and inflammation. Here, we evaluated terutroban (TBN), a specific TP receptor antagonist, for the prevention of post-haemorrhage blood-brain barrier disruption, neuronal apoptosis and delayed cerebral hypoperfusion. Read More

Semin Neurol 2019 Feb 11;39(1):20-26. Epub 2019 Feb 11.

Department of Emergency Medicine, Maricopa Medical Center, Phoenix, Arizona.

The acute headache in the emergency department (ED) poses a diagnostic dilemma that may overwhelm providers attempting to weigh the cost of advanced workups against the risk of missing serious pathology. While the majority of headache concerns are benign primary headache disorders, identifying life-threatening secondary causes of headache-which may be broadly categorized into structural, infectious, and vascular causes-is the primary focus of evaluation in the ED. Secondary headaches are associated with a high morbidity and mortality, and require strict scrutiny of the history and physical examination to adequately risk-stratify patients. Read More

World Neurosurg 2019 Feb 8. Epub 2019 Feb 8.

University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany, Department of Health Economics and Health Services Research.

Objective: Rupture of unruptured intracranial aneurysms (UIA) is the main cause for subarachnoid hemorrhage (SAH). UIA are widespread among the population. Advanced technology enables us to diagnose UIAs with increasing reliability and subsequently treat them. Read More

J Neurosci Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurological Surgery, Brigham and Women's Hospital, Boston, Massachusetts.

Thirty-day readmission rates has been increasingly used by clinicians, hospital administrators, and policy makers as a metric for the quality of care. However, the 30-day readmission rates may be affected by other factors intrinsic to the patient and may not be a good measure of the quality of care provided by the hospital. In this review, we examined the quality of the 30-day readmissions rate as a quality metric for the quality of care provided to patients with aneurysmal subarachnoid hemorrhage (SAH). Read More

J Neurol 2019 Feb 9. Epub 2019 Feb 9.

Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Delayed cerebral ischemia seriously affects the prognosis of patients surviving the initial aneurysmal subarachnoid hemorrhage. Application of cilostazol was reported to ameliorate vasospasm and improve outcomes in series and clinical trials. But the effectiveness and feasibility of cilostazol on aneurysmal subarachnoid hemorrhage remained controversial. Read More

Aging (Albany NY) 2019 Feb 9. Epub 2019 Feb 9.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Unidad de Neurocríticos, Sevilla, Spain.

J Neurosurg 2019 Feb 8:1-7. Epub 2019 Feb 8.

4Department of Neurosurgery, Royal Perth and Sir Charles Gairdner Hospitals, Perth, Western Australia, Australia.

OBJECTIVEHematological abnormalities after severe traumatic brain injury (TBI) are common, and are associated with a poor outcome. Whether these abnormalities offer additional prognostic significance over and beyond validated TBI prognostic models is uncertain.METHODSThis retrospective cohort study compared the ability of admission hematological abnormalities to that of the IMPACT (International Mission for Prognosis and Analysis of Clinical Trials) prognostic model to predict 18-month neurological outcome of 388 patients who required a decompressive craniectomy after severe TBI, between 2004 and 2016, in Western Australia. Read More

J Neurol Sci 2019 Feb 5;399:6-14. Epub 2019 Feb 5.

Neurology, Henry Ford Hospital, Detroit MI-48202, USA. Electronic address:

Subarachnoid hemorrhage (SAH) results in neurological damage, acute cardiac damage and has a high mortality rate. Immunoresponse in the acute phase after SAH plays a key role in mediating vasospasm, edema, inflammation and neuronal damage. The S1P/S1PR pathway impacts multiple cellular functions, exerts anti-inflammatory and anti-apoptotic effects, promotes remyelination, and improves outcome in several central nervous system (CNS) diseases. Read More

Transl Stroke Res 2019 Feb 8. Epub 2019 Feb 8.

Department of Molecular Pharmacology, Research Institute, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.

Intracranial aneurysm (IA) usually induced at a bifurcation site of intracranial arteries causes a lethal subarachnoid hemorrhage. Currently, IA is considered as a macrophage-mediated inflammatory disease triggered by a high wall shear stress (WSS) on endothelial cells. However, considered the fact that a high WSS can be observed at every bifurcation site, some other factors are required to develop IAs. Read More

J Clin Neurosci 2019 Feb 5. Epub 2019 Feb 5.

Department of Stereotactic and Functional Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106 Freiburg, Germany.

Delayed Cerebral Infarction (DCI) due to Cerebral Vasospasm (CVS) is an important contributor to poor outcome after aneurysmal subarachnoid haemorrhage (aSAH). Despite established risk factors CVS and DCI are unpredictable at the individual patient level. Efficient treatments are lacking. Read More

World Neurosurg 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurosurgery, University of Louisville, Louisville, Kentucky. Electronic address:

Background: Since the prognosis of high-grade aneurysmal subarachnoid hemorrhage (aSAH), classified as World Federation of Neurological Societies (WFNS) grade IV-V, is generally poor, the functional outcomes of survivors have not been thoroughly explored. The aim of this retrospective cohort study is to determine predictors of functional independence in patients who survive a high-grade aSAH.

Methods: We retrospectively evaluated consecutive aSAH patients admitted to a single institution from January 2000 to April 2015. Read More

Stroke 2018 Dec;49(12):3081-3084

From the Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience Center, University of Zurich, Switzerland (M.N.S., E.K., O.B., L.R.)

Background and Purpose—Commonly used tools to determine functional outcome after aneurysmal subarachnoid hemorrhage (aSAH) have limitations. Time spent at the patient’s home has previously been proposed as a robust outcome measure after ischemic stroke. Here, we set out to validate home-time as an outcome measure after aSAH. Read More

Minerva Anestesiol 2019 Feb 7. Epub 2019 Feb 7.

Australian and New Zealand Intensive Care Research Centre (ANZIC RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia -

Background: Traumatic Brain Injury (TBI) and Sub-Arachnoid Hemorrhage (SAH) are the most common causes of severe acute brain injury in younger Intensive Care Unit (ICU) patients. Dysglycemia (abnormal peak glycemia, glycemic variability, mean glycemia, nadir glycemia) is common in these patients but its comparative outcome associations are unclear.

Methods: In a retrospective, cross-sectional, study of adults admitted to Australian and New Zealand ICUs with TBI and SAH (TBI&SAH) from 2005 to 2015, we studied the relationship between multiple aspects of early (first 24 hours) dysglycemia and mortality and compared TBI and SAH patients with the general ICU population and with each other. Read More

Pharmacotherapy 2019 Feb 7. Epub 2019 Feb 7.

University Hospitals Cleveland Medical Center, Cleveland, OH.

Optimal blood pressure management is controversial in neurocritically ill patients due to conflicting concerns of worsening ischemia with decreased blood pressure versus cerebral edema and increased intracranial pressure with elevated blood pressure. In addition, there is a lack of high-quality evidence regarding optimal blood pressure goals in patients with most of these conditions. This review summarizes guideline recommendations and examines the literature for blood pressure management in patients with ischemic stroke, intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, traumatic brain injury, and spinal cord injury. Read More

Clin Neuroradiol 2019 Feb 7. Epub 2019 Feb 7.

Department of Neuroradiology, University Hospital of Cologne, Kerpener Straße 67, 50937, Cologne, Germany.

Purpose: The Woven EndoBridge (WEB) device has been proven to be a safe and efficient endovascular treatment option for wide-necked bifurcation aneurysms. The study aimed to evaluate the incidence and risk factors of procedural complications related to WEB embolization of ruptured and unruptured intracranial aneurysms.

Methods: This was a multicenter, observational study of consecutive patients with ruptured and unruptured aneurysms who were treated with the WEB at three German tertiary care centers between May 2011 and February 2018. Read More

J Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Neuroradiologische Klinik, Neurozentrum, Klinikum Stuttgart, Germany; Medical Faculty, University Duisburg-Essen, Germany.

Basilar perforator artery aneurysms (BAPA's) are an under-recognised cause of sub-arachnoid haemorrhage (SAH). We present our single centre experience of BAPA's and review of the literature. We performed a retrospective review of our prospectively maintained database to identify all BAPA's that presented acute SAH between February 2009 and February 2018. Read More

PLoS One 2019 7;14(2):e0211868. Epub 2019 Feb 7.

Neurosurgical Center Amsterdam, Amsterdam UMC, Univ(ersity) of Amsterdam, Amsterdam, the Netherlands.

Background: Recurrent bleeding is one of the major causes of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). Antifibrinolytic therapy is known to reduce recurrent bleeding, however, its beneficial effect on outcome remains unclear. The effect of treatment with tranexamic acid (TXA) until aneurysm treatment on clinical outcome is evaluated. Read More

Neurocrit Care 2019 Feb 6. Epub 2019 Feb 6.

Department of Anesthesiology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

Background: Oral nimodipine is used for prophylaxis and treatment of delayed cerebral ischemia in patients with aneurysmal or perimesencephalic subarachnoid hemorrhage (SAH). In cases of serious refractory cerebral vasospasm, a continuous intra-arterial (IA) infusion of nimodipine (CIAN) may be required to avoid cerebral ischemia. Nimodipine can cause arterial hypotension requiring either a dosage reduction or its discontinuation. Read More

World Neurosurg 2019 Feb 2. Epub 2019 Feb 2.

Clinical Professor, Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, FRCS, MS, PhD, LLM. Electronic address:

Background: Fall with head injury is an epidemic challenge especially with the aging population. Contributing factors for mortality included the development of cerebral contusions and delayed traumatic intracerebral hematoma. Currently, there is no established treatment for these conditions. Read More

World Neurosurg 2019 Feb 2. Epub 2019 Feb 2.

Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Background: and Importance: Cerebral arteriovenous malformations (CAVM) are characterized by altered hemodynamics and associated with angioanatomical changes, such as aneuryms. We encountered a patient with a CAVM-associated dissection of the medial trunk of the posterior inferior cerebellar artery (PICA) instead of an aneurysm.

Clinical Presentation: We report the case of a 56-year old male patient with spontaneous subarachnoid hemorrhage within the cisterna magna and fourth ventricle. Read More

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(6):105-113

Burdenko Neurosurgical Institute, Moscow, Russia.

The use of endoscopic technique has significantly extended the indications for surgery using the transsphenoidal approach. Currently, more than 90% of pituitary adenomas are operated on transsphenoidally. Transnasal removal of giant pituitary adenomas has become possible. Read More