29,197 results match your criteria Subarachnoid Hemorrhage


Ruptured intrameatal anterior inferior cerebellar artery aneurysm associated with obstructed internal auditory artery in a patient with sudden hearing loss and vertigo.

Acta Neurochir (Wien) 2018 Dec 17. Epub 2018 Dec 17.

Department of Cerebrovascular Surgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan.

Background: Intrameatal aneurysms arising from the meatal loop of the anterior inferior cerebellar artery (AICA) are extremely rare.

Case Presentation: We report a 60-year-old man presenting with severe vertigo and sudden left hearing loss associated with subarachnoid hemorrhage caused by rupture of a saccular aneurysm arising from the meatal loop of the AICA, which was entirely buried in the meatus. Intraoperatively, we identified the occluded internal auditory artery arising from the meatal loop of the AICA, where the aneurysm originated, and performed neck clipping. Read More

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http://dx.doi.org/10.1007/s00701-018-3771-xDOI Listing
December 2018

Early Life Body Size in Relation to First Intracerebral or Subarachnoid Hemorrhage.

J Stroke 2018 Dec 18. Epub 2018 Dec 18.

Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Background And Purpose: As risk of hemorrhagic stroke may have early life origins, we investigated associations of birth weight and childhood body mass index (BMI) with adult intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH).

Methods: We included 240,234 Danish schoolchildren, born 1936 to 1989, with information on birth weight and measured weights and heights from 7 to 13 years. We calculated hazard ratios (HRs) and confidence intervals (CIs) for the associations between early life anthropometrics and ICH or SAH, identified through linkage with national registers. Read More

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http://dx.doi.org/10.5853/jos.2018.02033DOI Listing
December 2018

Executive Summary of Stroke Statistics in Korea 2018: A Report from the Epidemiology Research Council of the Korean Stroke Society.

J Stroke 2018 Dec 18. Epub 2018 Dec 18.

Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Despite the great socioeconomic burden of stroke, there have been few reports of stroke statistics in Korea. In this scenario, the Epidemiologic Research Council of the Korean Stroke Society launched the "Stroke Statistics in Korea" project, aimed at writing a contemporary, comprehensive, and representative report on stroke epidemiology in Korea. This report contains general statistics of stroke, prevalence of behavioral and vascular risk factors, stroke characteristics, pre-hospital system of care, hospital management, quality of stroke care, and outcomes. Read More

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http://dx.doi.org/10.5853/jos.2018.03125DOI Listing
December 2018

Cerebral venous sinus thrombosis presenting with multifocal intracerebral hemorrhage and subarachnoid hemorrhage: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13476

Department of Neurology.

Rationale: Multifocal cerebral hemorrhage refers to the cerebral hemorrhage in 2 or more lesions at the same time or 48 h in the brain caused by various causes, which has an acute onset, high mortality rate, and poor clinical treatment effect. Subarachnoid hemorrhage (SAH) is caused by the direct flow of blood into the subarachnoid cavity due to the rupture of the diseased vessels at the base or surface of the brain. Cerebral venous sinus thrombosis (CVST) affects approximately 5 people per million and accounts for approximately 1% of all stroke events. Read More

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http://dx.doi.org/10.1097/MD.0000000000013476DOI Listing
December 2018

Recovery process of bilaterally injured corticoreticulospinal tracts in a patient with subarachnoid hemorrhage: Case report.

Medicine (Baltimore) 2018 Dec;97(50):e13401

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, Republic of Korea.

Rationale: A few studies using diffusion tensor tractography (DTT) have demonstrated recovery of injured corticoreticulospinal tract (CRT) in patients with intracerebral hemorrhage and infarct. However, no study reported on a patient who showed peri-infarct reorganization of an injured CRT following a middle cerebral artery territory infarct.

Patient Concerns: A 56-year-old right-handed male patient was diagnosed as spontaneous subarachnoid hemorrhage (SAH) and intraventricular hemorrhage (IVH) and underwent clipping for a ruptured anterior communicating artery aneurysm and right frontal extraventricular drainage for IVH at the department of neurosurgery of a university hospital. Read More

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http://dx.doi.org/10.1097/MD.0000000000013401DOI Listing
December 2018

Ischemic Lesions in Acute and Subacute Perimesencephalic Subarachnoid Hemorrhage.

AJR Am J Roentgenol 2018 Dec 17:1-7. Epub 2018 Dec 17.

5 Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.

Objective: Perimesencephalic hemorrhage (PMH) is a subtype of nonaneurysmal subarachnoid hemorrhage (SAH). In patients with aneurysmal SAH, the occurrence of acute ischemic lesions is associated with severity and poor outcome. We investigated the frequency of ischemic lesions on DWI in patients with PMH and compared it with the frequency of ischemic lesions in patients with aneurysmal SAH. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.19700
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http://dx.doi.org/10.2214/AJR.18.19700DOI Listing
December 2018
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Real-time Imaging of an Experimental Intracranial Aneurysm in Rats.

Neurol Med Chir (Tokyo) 2018 Dec 15. Epub 2018 Dec 15.

Department of Molecular Pharmacology, Research Institute, National Cerebral and Cardiovascular Center.

Subarachnoid hemorrhage due to rupture of a pre-existing intracranial aneurysm has quite a poor outcome in spite of intensive medical care. Hemodynamic stress loaded on intracranial arterial walls is considered as a trigger and a regulator of formation and progression of the disease, but how intracranial arterial walls or intracranial aneurysm walls behave under hemodynamic stress loading remains unclear. The purpose of this study was to visualize and analyze the wall motion of intracranial aneurysms to detect a pathological flow condition. Read More

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http://dx.doi.org/10.2176/nmc.oa.2018-0197DOI Listing
December 2018

Targeting mast cell as a neuroprotective strategy.

Brain Inj 2018 Dec 17:1-11. Epub 2018 Dec 17.

a Department of Basic Sciences, Division of Physiology , Loma Linda University School of Medicine , Loma Linda , CA , USA.

Background: Mast cells (MCs) are perivascularly located immune cells of haematopoietic origin. Emerging evidences suggest that the activation of MCs play important roles in the pathogenesis of blood brain barrier disruption, neuroinflammation, and neurodegeneration.

Objectives: In this review, we aimed to discuss the detrimental effects of MCs in response to various types of brain injury, as well as the therapeutic potential and neuroprotective effects of targeting the activation and degranulation of MCs, particularly in the management of the acute phase. Read More

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http://dx.doi.org/10.1080/02699052.2018.1556807DOI Listing
December 2018

Incidence of the initiation of comfort care immediately following emergent neurosurgical and endovascular procedures.

Authors:

J Neurosurg 2018 Dec 14:1-9. Epub 2018 Dec 14.

OBJECTIVEIt is unknown what proportion of patients who undergo emergent neurosurgical procedures initiate comfort care (CC) measures shortly after the operation. The purpose of the present study was to analyze the proportion and predictive factors of patients who initiated CC measures within the same hospital admission after undergoing emergent neurosurgery.METHODSThis retrospective cohort study included all adult patients who underwent emergent neurosurgical and endovascular procedures at a single center between 2009 and 2014. Read More

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http://dx.doi.org/10.3171/2018.7.JNS181226DOI Listing
December 2018

Pipeline shield with single antiplatelet therapy in aneurysmal subarachnoid haemorrhage: multicentre experience.

J Neurointerv Surg 2018 Dec 14. Epub 2018 Dec 14.

Institute of Neurological Sciences, Prince of Wales Hospital, Randwick, New South Wales, Australia.

Background: The Pipeline Embolisation Device with Shield technology (PED-Shield) is suggested to have reduced thrombogenicity. This reduced thrombogenicity may make it possible to use safely in the acute treatment of aneurysmal subarachnoid haemorrhage (aSAH) on single antiplatelet therapy (SAPT).

Objective: To evaluate the safety and efficacy of the off-label use of PED-Shield with SAPT for the acute treatment of aSAH. Read More

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http://dx.doi.org/10.1136/neurintsurg-2018-014363DOI Listing
December 2018

Puerarin attenuates neurological deficits via Bcl-2/Bax/cleaved caspase-3 and Sirt3/SOD2 apoptotic pathways in subarachnoid hemorrhage mice.

Biomed Pharmacother 2019 Jan 5;109:726-733. Epub 2018 Nov 5.

Department of Neurosurgery, Huashan Hospital Affiliated to Fudan University, 12 Wulongmuqi Middle Road, Shanghai, 200040, PR China. Electronic address:

Background: Subarachnoid hemorrhage (SAH) results in many brain dysfunctions and the neuroprotective function of puerarin after brain damage has been demonstrated in several studies. But whether puerarin can reduce brain nerve damage after SAH is not clear.In this study, we hypothesized that puerarin had the neuroprotective effect after SAH, and this protection could be mediated by bothBcl-2/Bax/Cleaved caspase-3 and SIRT3/SOD2 apoptotic signaling pathways. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.10.161DOI Listing
January 2019

Effects of nimodipine, vinpocetine and their combination on isoproterenol-induced myocardial infarction in rats.

Biomed Pharmacother 2019 Jan 12;109:1372-1380. Epub 2018 Nov 12.

Department of Pharmacology, School of Pharmaceutical Education & Research (SPER), Jamia Hamdard, New Delhi, 110062, India. Electronic address:

Background: Myocardial infarction (MI) remains a major cause of morbidity and mortality worldwide. Nimodipine is a calcium (Ca channel blocker as well as a PDE1 inhibitor and primarily used in subarachnoid haemorrhage (SAH) due to its blood-brain barrier crossing property. Nimodipine and vinpocetine inhibit the degradation of phosphodiester bond which increases cGMP and cAMP levels causing vasodilation. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.10.199DOI Listing
January 2019
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Basal ganglia hemorrhage in a case report following spinal surgery.

BMC Neurol 2018 Dec 14;18(1):204. Epub 2018 Dec 14.

Neurosurgery and Radiology, Neurology Department, University of Minnesota, Minneapolis, MN, USA.

Background: Intracranial hemorrhage is a rare but potentially severe complication of spinal surgery. Most reported post-operative ICH cases consist of cerebellar hemorrhage. There are fewer reported cases of supratentorial ICH following spinal surgery. Read More

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http://dx.doi.org/10.1186/s12883-018-1218-xDOI Listing
December 2018

Aneurysm rebleeding before therapy: a predictable disaster?

Authors:

J Neurosurg 2018 Nov 1:1-8. Epub 2018 Nov 1.

OBJECTIVECurrent guidelines for subarachnoid hemorrhage (SAH) include early aneurysm treatment within 72 hours after ictus. However, aneurysm rebleeding remains a crucial complication of SAH. The aim of this study was to identify independent predictors allowing early stratification of SAH patients for rebleeding risk. Read More

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http://dx.doi.org/10.3171/2018.7.JNS181119DOI Listing
November 2018

Terminal spreading depolarizations causing electrocortical silencing prior to clinical brain death: case report.

Authors:

J Neurosurg 2018 Dec 1:1-7. Epub 2018 Dec 1.

The authors report on a 57-year-old woman in whom progression to brain death occurred on day 9 after aneurysmal subarachnoid hemorrhage without evidence of significant brain edema or vasospasm. Neuromonitoring demonstrated that brain death was preceded by a series of cortical spreading depolarizations that occurred in association with progressive hypoxic episodes. The depolarizations induced final electrical silence in the cortex and ended with a terminal depolarization that persisted > 7 hours. Read More

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http://dx.doi.org/10.3171/2018.7.JNS181478DOI Listing
December 2018

Post-treatment Antiplatelet Therapy Reduces Risk for Delayed Cerebral Ischemia due to Aneurysmal Subarachnoid Hemorrhage.

Neurosurgery 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, University Hospital, University of Duisburg-Essen, Essen, Germany.

Background: Delayed cerebral ischemia (DCI) has a strong impact on outcome of patients with aneurysmal subarachnoid hemorrhage (SAH). Positive effect of antiplatelet therapy on DCI rates has been supposed upon smaller SAH series.

Objective: To analyze the benefit/risk profile of antiplatelet use in SAH patients. Read More

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http://dx.doi.org/10.1093/neuros/nyy550DOI Listing
December 2018

Comparison of carotid and basilar bifurcation aneurysms versus non-T-angled bifurcations: the geometry is associated with the outcome.

Neurosurg Rev 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, Goethe-University Hospital, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.

Patients with ruptured aneurysms of carotid bifurcation artery seem to suffer less often from cerebral vasospasm and early brain injury and have a better clinical outcome. Aim of our study was to identify differences in clinical course and outcome in aneurysms of terminus segments (carotid bifurcation artery and basilar tip) compared to aneurysms of other aneurysm locations except carotid bifurcation artery and basilar tip. Patients with SAH were entered into a prospectively collected database (1999 to June 2014). Read More

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http://dx.doi.org/10.1007/s10143-018-01056-2DOI Listing
December 2018

Stents and Stent Mimickers in Endovascular Management of Wide-neck Intracranial Aneurysms.

Cureus 2018 Oct 5;10(10):e3420. Epub 2018 Oct 5.

Radiology, The Aga Khan University, Karachi, PAK.

Subarachnoid hemorrhage due to a ruptured cerebral aneurysm is a disastrous event accounting for approximately 5%-15% of all stroke cases and has a high mortality rate. One of the major goals in the management of these patients is to prevent rebleeding by securing the aneurysm either surgically or by endovascular means. Endovascular treatment is considered the first line of treatment for intracranial aneurysms; however, wide-neck aneurysms (WNAs) are specifically difficult to treat by endovascular means due to the difficulty in achieving a stable coil mass inside the aneurysm sac. Read More

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http://dx.doi.org/10.7759/cureus.3420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284878PMC
October 2018

Incidence of Cardiac Dysfunction After Brain Injury.

Med Arch 2018 Nov;72(5):316-318

Clinic for Surgery, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.

Introduction: Cardiovascular complications in patients with subarachnoid hemorrhage are considered to be a neurally mediated process rather than a manifestation of coronary artery disease.

Aim: The aim of study is to show the incidence and type cardiac complications after traumatic and spontaneous SAH.

Patients And Methods: The study had prospective character in which included 104 patients, with diagnosed subarachnoid hemorrhage (SAH), in the period from 2014 to 2017. Read More

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http://dx.doi.org/10.5455/medarh.2018.72.316-318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282908PMC
November 2018

Angiographic Features of Intracranial Aneurysms in Ecuador.

J Stroke Cerebrovasc Dis 2018 Dec 3. Epub 2018 Dec 3.

University of Iowa School of Medicine, Universidad San Francisco de Quito, Quito, Ecuador, USA.

Background: Most of the literature describing morphological features of intracranial aneurysms (IAs) is from North-America, East-Asia, and Europe. There is limited data from South-America. We describe the epidemiologic and angiographic features of ruptured and unruptured IAs in a cohort of patients from Ecuador. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.020DOI Listing
December 2018

Time Trends in Outcomes After Aneurysmal Subarachnoid Hemorrhage Over the Past 30 Years.

Mayo Clin Proc 2018 Dec;93(12):1786-1793

Department of Neurologic Surgery, Mayo Clinic, Rochester, MN; Department of Radiology, Mayo Clinic, Rochester, MN. Electronic address:

Objective: To analyze trends in mortality rates, functional outcomes, and treatment in patients with aneurysmal subarachnoid hemorrhage (aSAH) over the past 3 decades.

Patients And Methods: We conducted a retrospective review of consecutive patients with aSAH treated at Mayo Clinic in Rochester, Minnesota, between January 1, 1985, and December 31, 2014.

Results: A total of 1173 patients identified were grouped by decade of treatment: 1985 to 1994, n=274; 1995 to 2004, n=461; and 2005 to 2014, n=438. Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.06.027DOI Listing
December 2018

Comparison of PED and FRED Flow Diverters for Internal Carotid Artery Aneurysms: A Propensity Score-Matched Cohort Study.

Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurology, Paracelsus Medical University, Salzburg, Austria.

Background: Flow diversion has become an accepted endovascular treatment modality for intracranial aneurysms. Studies comparing different types of flow diverters are currently lacking.

Objective: To perform a propensity score-matched cohort study comparing the Pipeline Embolization Device (PED; Medtronic, Dublin, Ireland) and Flow Redirection Endoluminal Device (FRED; MicroVention, Aliso Viejo, California). Read More

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https://academic.oup.com/neurosurgery/advance-article/doi/10
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http://dx.doi.org/10.1093/neuros/nyy572DOI Listing
December 2018
2 Reads

Subarachnoid extension of lobar hemorrhage on acute/subacute MRI is associated with cerebral amyloid angiopathy criteria.

Acta Neurol Belg 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurology, CHU Nîmes, Hôpital Caremeau, Nîmes University Hospital, 4, Rue du Pr Debré, 30029, Nîmes Cedex 4, France.

Subarachnoid hemorrhage extension (SAHE) in the acute phase of cerebral amyloid angiopathy (CAA)-related lobar hemorrhage (LH) assessed by CT is very frequent. Recently, SAHE, together with finger-like projections on CT and ApoE4, has been used in a prediction model for histopathologically proven CAA showing excellent discrimination. Our aim was to analyze SAHE on MRI in the acute and subacute phase of LH in patients with and without associated hemorrhagic features supportive of CAA (i. Read More

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http://dx.doi.org/10.1007/s13760-018-01060-9DOI Listing
December 2018
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Predictors of cognitive function in the acute phase after aneurysmal subarachnoid hemorrhage.

Acta Neurochir (Wien) 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, P.B. 4950, Nydalen, 0424, Oslo, Norway.

Background: Cognitive dysfunction is the most common form of neurological impairment after aneurysmal subarachnoid hemorrhage (aSAH) in the chronic phase. Cognitive deficits in the acute phase after aSAH, however, remain scarcely investigated. The aim of the present study was to test cognitive function and to identify medical predictors of cognitive deficits in the acute phase of aSAH. Read More

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http://link.springer.com/10.1007/s00701-018-3760-0
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http://dx.doi.org/10.1007/s00701-018-3760-0DOI Listing
December 2018
2 Reads

Early Intracranial Aneurysm Recurrence after Microsurgical Clip Ligation: Case Report and Review of the Literature.

J Neurol Surg Rep 2018 Oct 7;79(4):e93-e97. Epub 2018 Dec 7.

Department of Neurosurgery, Kantonsspital Aarau (KSA), Aarau, Switzerland.

Microsurgical clip ligation is considered a definitive treatment for intracranial aneurysms (IAs), resulting in low rates of local recurrence that range from 0.2 to 0.5% and a latency period that averages about a decade. Read More

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http://dx.doi.org/10.1055/s-0038-1676454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286179PMC
October 2018

Endovascular Therapy for Ruptured Vertebral Artery Dissecting Aneurysms: Results from Nationwide, Retrospective, Multi-Center Registries in Japan (JR-NET3).

Neurol Med Chir (Tokyo) 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurosurgery, Kobe City Medical Center General Hospital.

Ruptured vertebral artery dissecting aneurysm (VADA) causes subarachnoid hemorrhage (SAH), and parent artery occlusion (PAO) with endovascular technique (EVT) has been the first-line treatment for ruptured VADA. In this study, we have extracted 530 ruptured VADA, treated through PAO with EVT, from a nationwide, retrospective, multi-center registration in Japan (JR-NET3), and analyzed factors associated with outcome at 30 days and procedure-related complications. Complete occlusion was achieved in 497 cases (93. Read More

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https://www.jstage.jst.go.jp/article/nmc/advpub/0/advpub_st.
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http://dx.doi.org/10.2176/nmc.st.2018-0191DOI Listing
December 2018
1 Read

Lessons from tenascin-C knockout mice and potential clinical application to subarachnoid hemorrhage.

Neural Regen Res 2019 Feb;14(2):262-264

Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu, Japan.

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http://dx.doi.org/10.4103/1673-5374.244789DOI Listing
February 2019

Preventing vessel perforations in endovascular thrombectomy: feasibility and safety of passing the clot with a microcatheter without microwire: the wireless microcatheter technique.

J Neurointerv Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Neuroradiology, University Hospital Aachen, Aachen, Germany.

Background: To place a stent retriever for thrombectomy in acute ischemic stroke, the clot has to be passed first. A microwire is usually used for this maneuver. As an alternative, a wireless microcatheter can be used to pass the clot. Read More

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http://dx.doi.org/10.1136/neurintsurg-2018-014267DOI Listing
December 2018
1 Read

Cortical surface intracranial electrodes identify clinically relevant seizures missed on scalp EEG after traumatic intracranial hemorrhage.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.

Seizures and other electrophysiological disturbances are an under-recognized cause of coma, focal deficits, and prolonged encephalopathy following subdural hematoma evacuation. In these patients, it is possible that seizures remain unrecognized on scalp EEG. It has been shown that a high burden of seizures and other electrophysiological disturbances exist following surgical evacuation and underlie the encephalopathy commonly seen in this patient population, predisposing them to medical complications and confounding estimates of prognosis. Read More

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http://dx.doi.org/10.1684/epd.2018.1015DOI Listing
December 2018

Spiked helmet pattern ST elevation in subarachnoid hemorrhage.

J Electrocardiol 2018 Nov 28;52:96-98. Epub 2018 Nov 28.

Department of Internal Medicine, Carolinas Medical Center, Charlotte, NC, USA. Electronic address:

Subarachnoid hemorrhage (SAH) is occasionally associated with the electrocardiographic (ECG) pattern of ST-segment elevation myocardial infarction (STEMI). Missing the true clinical diagnosis can result in inappropriate and harmful interventions. We report the case of a 40-year-old female who was found down. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2018.11.016DOI Listing
November 2018

Superficial siderosis associated with craniopharyngioma: a rare case report.

World Neurosurg 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan.

Superficial siderosis (SS) associated with craniopharyngioma is an extremely rare occurrence. To our knowledge, only three cases have been reported in literature. Two of the cases occurred following resection of the tumor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183278
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http://dx.doi.org/10.1016/j.wneu.2018.11.222DOI Listing
December 2018
1 Read

Temporal profile of serum mitochondrial DNA (mtDNA) in patients with aneurysmal subarachnoid hemorrhage (aSAH).

Mitochondrion 2018 Dec 5. Epub 2018 Dec 5.

Department of Neurosurgery, University Hospital Bonn, University of Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany; Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address:

Aneurysmal subarachnoid hemorrhage (aSAH) is a highly complex disease. Majority of aSAH survivors confront post-SAH complications including cerebral vasospasm (CVS) and delayed cerebral ischemia (DCI) that mainly influence the clinical outcome. Tissue damage during early brain injury may lead to release of damage associated molecular pattern molecules (DAMPs) that may initiate and sustain inflammation during the course of aSAH through activation of pattern recognition receptors. Read More

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http://dx.doi.org/10.1016/j.mito.2018.12.001DOI Listing
December 2018

Incidence of epilepsy and associated factors in elderly patients in Germany.

Epilepsy Behav 2018 Dec 4;90:107-111. Epub 2018 Dec 4.

Epidemiology, IQVIA, Frankfurt, Germany. Electronic address:

Aims: Little is known about the recent epidemiology of epilepsy in the elderly in Germany. Therefore, the goal of this study was to analyze the incidence of epilepsy and associated factors in elderly patients followed in general practices in this country.

Methods: The incidence of epilepsy was estimated using data from all patients aged ≥60 years who were followed in 1203 general practices in Germany in 2017 (IQVIA Disease Analyzer database). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183081
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http://dx.doi.org/10.1016/j.yebeh.2018.10.035DOI Listing
December 2018
1 Read

Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility.

Lancet 2018 Dec 4. Epub 2018 Dec 4.

Division of Gynaecology, Department of Obstetrics and Gynaecology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.

Background: Uterus transplantation from live donors became a reality to treat infertility following a successful Swedish 2014 series, inspiring uterus transplantation centres and programmes worldwide. However, no case of livebirth via deceased donor uterus has, to our knowledge, been successfully achieved, raising doubts about its feasibility and viability, including whether the womb remains viable after prolonged ischaemia.

Methods: In September, 2016, a 32-year-old woman with congenital uterine absence (Mayer-Rokitansky-Küster-Hauser [MRKH] syndrome) underwent uterine transplantation in Hospital das Clínicas, University of São Paulo, Brazil, from a donor who died of subarachnoid haemorrhage. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183176
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http://dx.doi.org/10.1016/S0140-6736(18)31766-5DOI Listing
December 2018
1 Read

Left Atrial Appendage Closure Device Implantation in Patients with Prior Intracranial Hemorrhage.

Heart Rhythm 2018 Nov 19. Epub 2018 Nov 19.

Section of Cardiac Pacing and Electrophysiology, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH. Electronic address:

Background: The Watchman™ device (Boston Scientific, MN), used for left atrial appendage closure (LAAC) was approved for stroke prevention in patients with atrial fibrillation (AF) and an appropriate rationale to avoid long-term oral anticoagulation. Patients with AF and prior intracranial hemorrhage (ICH) were excluded from clinical trials due to perceived risks of peri-operative anticoagulation.

Objective: We studied the efficacy and safety of LAAC using Watchman™ in patients with AF and prior ICH. Read More

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http://dx.doi.org/10.1016/j.hrthm.2018.11.022DOI Listing
November 2018
2 Reads

Aneurysmal Subarachnoid Hemorrhage Onset Alters Pyruvate Metabolism in Poor-Grade Patients and Clinical Outcome Depends on More: A Cerebrospinal Fluid Metabolomic Study.

ACS Chem Neurosci 2018 Dec 6. Epub 2018 Dec 6.

Cerebral metabolism alterations influence cerebrospinal fluid (CSF) composition, and is sensitive to brain injury. In subarachnoid hemorrhage (SAH) patients, Fisher scale, Hunt-Hess scale and World Federation of Neurological Societies (WFNS) grading scales evaluating SAH severity are inadequate to predict long-term outcome; therefore, in an effort to determine metabolite pattern disparity and discover corresponding biomarkers, we designed an untargeted CSF metabolomic research covering a board range of metabolites of SAH patients with different severity and outcome. The present study demonstrated SAH altered cerebrospinal fluid metabolome involving carbohydrate, lipid and amino acids metabolism. Read More

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http://pubs.acs.org/doi/10.1021/acschemneuro.8b00581
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http://dx.doi.org/10.1021/acschemneuro.8b00581DOI Listing
December 2018
2 Reads

MRI Presentation of Infectious Intracranial Aneurysms in Infective Endocarditis.

Neurocrit Care 2018 Dec 5. Epub 2018 Dec 5.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: The radiographic appearance of infectious intracranial aneurysms (IIAs) of infective endocarditis (IE) on magnetic resonance imaging (MRI) of brain is varied. We aimed to describe the IIA-specific MRI features in a series of patients with IIAs.

Methods: Records of patients with active IE who had digital subtraction angiography (DSA) at a tertiary medical center from January 2011 to December 2016 were reviewed. Read More

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http://link.springer.com/10.1007/s12028-018-0654-1
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http://dx.doi.org/10.1007/s12028-018-0654-1DOI Listing
December 2018
5 Reads

Spontaneous Acute Subdural Hematoma Associated with Arachnoid Cyst and Intra-cystic Hemorrhage.

Cureus 2018 Sep 28;10(9):e3383. Epub 2018 Sep 28.

Neurosurgery, Advocate Christ Medical Center, Oak Lawn, USA.

Arachnoid cysts (ACs) are congenital, extra-axial lesions containing fluid similar to the composition of cerebrospinal fluid. Usually found incidentally, these lesions are observed with serial imaging to document their growth patterns and stability, and are then followed conservatively until clinical symptoms develop. Surgical options for symptomatic arachnoid cysts include cyst aspiration, cyst evacuation with fenestration into the subarachnoid space, and shunt procedures including cysto-peritoneal and cysto-ventricular shunts. Read More

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http://dx.doi.org/10.7759/cureus.3383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263493PMC
September 2018
1 Read

Clazosentan for aneurysmal subarachnoid hemorrhage: An updated meta-analysis with trial sequential analysis.

World Neurosurg 2018 Nov 30. Epub 2018 Nov 30.

Institute of New Frontier Research, Hallym University College of Medicine, Chuncheon, Korea; Department of Neurosurgery, Hallym University College of Medicine, Chuncheon, Korea. Electronic address:

Object: Clazosentan, an endothelin-receptor-antagonist, reduced vasospasm and delayed-ischemic-neurological-deficit (DIND) but did not improve outcome following subarachnoid hemorrhage (SAH) in clinical trials. However, a lack of dose-dependent analysis and potential overestimation of clazosentan's effect are concerning. We employ stratified analysis and trial-sequential-analysis (TSA) of existing data to investigate the effects of clazosentan on SAH outcome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183252
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http://dx.doi.org/10.1016/j.wneu.2018.10.213DOI Listing
November 2018
2 Reads

The use of flow diverters to treat small (≤5 mm) ruptured, saccular aneurysms.

Surg Neurol Int 2018 30;9:216. Epub 2018 Oct 30.

Neuroradiological Clinic, Neurocenter, Leipzig, Germany.

Background: There is limited published literature on the use of flow diverting stents (FDS) to treat ruptured intracranial aneurysms in the acute stage. We present our experience of using FDS to treat small (≤5 mm) ruptured aneurysms.

Methods: We retrospectively identified all patients with ≤5 mm ruptured aneurysms treated exclusively with FDS between February 2009 and February 2016. Read More

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http://dx.doi.org/10.4103/sni.sni_243_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219287PMC
October 2018
1 Read

The Role of Neuroprotection in Subarachnoid Haemorrhage.

Turk J Anaesthesiol Reanim 2018 Dec 1;46(6):479. Epub 2018 Dec 1.

Department of Anesthesiology and Intensive Care, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey.

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http://dx.doi.org/10.5152/TJAR.2018.30633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223876PMC
December 2018
1 Read

Does Neuroprotection Still Have a Role in Injured Brain Following Aneurysmal Subarachnoid Haemorrhage?

Authors:
Giovanni Grasso

Turk J Anaesthesiol Reanim 2018 Dec 1;46(6):478-479. Epub 2018 Dec 1.

Department of Experimental Biomedicine and Clinical Neurosciences (BIONEC), University of Palermo, Palermo, Italy.

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http://dx.doi.org/10.5152/TJAR.2018.99896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223863PMC
December 2018
1 Read

Surgery for very large and giant intracranial aneurysms: Results and complications.

Neurol India 2018 Nov-Dec;66(6):1741-1757

Department of Neurosurgery, University of Washington, Seattle, Washington, USA.

Background: Results of and the complications encountered during surgery for very large and giant intracranial aneurysms are illustrated.

Objective: To analyze a consecutive series of patients with very large and giant aneurysms treated with microsurgery.

Methods: This retrospective study included seventy six very large and giant aneurysms which were managed by clipping and bypass technique. Read More

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http://dx.doi.org/10.4103/0028-3886.246291DOI Listing
December 2018
1 Read

Outcome assessment following aneurysmal subarachnoid hemorrhage - need for a comprehensive tool.

Authors:
Girish Menon

Neurol India 2018 Nov-Dec;66(6):1718-1720

Department of Neurosurgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

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http://dx.doi.org/10.4103/0028-3886.246220DOI Listing
December 2018
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Neurological, neuropsychological, and functional outcome after good grade aneurysmal subarachnoid hemorrhage.

Neurol India 2018 Nov-Dec;66(6):1713-1717

Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Background: There is a paucity of information about which impairments, cognitive or neurological, determine the functional outcome after aneurysmal subarachnoid hemorrhage (SAH). The present study aims to determine the relative contributions of each of the above impairments for determining the functional outcome after SAH.

Materials And Methods: This is a prospective observational study including patients with aneurysmal SAH. Read More

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http://dx.doi.org/10.4103/0028-3886.246243DOI Listing
December 2018
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Status epilepticus related to pregnancy: Devising a protocol for use in the intensive care unit.

Neurol India 2018 Nov-Dec;66(6):1629-1633

Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

Background: Status epilepticus (SE) related to pregnancy is rare and carries a significant risk to both the mother and the fetus.

Objectives: We conducted this study to devise a protocol for the management of SE related to pregnancy in a cohort of female patients admitted with SE during pregnancy.

Materials And Methods: All women who developed SE related to pregnancy (gestation, labor, and puerperium) between January 2000 and December 2016 were included. Read More

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http://dx.doi.org/10.4103/0028-3886.246279DOI Listing
December 2018
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Continuous EEG is associated with favorable hospitalization outcomes for critically ill patients.

Neurology 2018 Nov 30. Epub 2018 Nov 30.

From the Department of Neurology (C.E.H., L.J.B., D.T., K.A.D., N.D., B.L., A.W.W.), Leonard Davis Institute of Health Economics (C.E.H., N.D., A.W.W.), Translational Center of Excellence for Neurology Outcomes Research, Department of Neurology (D.T., A.W.W.), and Department of Biostatistics, Epidemiology and Informatics (A.W.W.), University of Pennsylvania, Philadelphia.

Objective: To characterize continuous EEG (cEEG) use patterns in the critically ill and to determine the association with hospitalization outcomes for specific diagnoses.

Methods: We performed a retrospective cross-sectional study with National Inpatient Sample data from 2004 to 2013. We sampled hospitalized adult patients who received intensive care and then compared patients who underwent cEEG to those who did not. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006689DOI Listing
November 2018
1 Read

Factors Predicting Ventriculostomy Revision at a Large Academic Medical Center.

World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurosurgery, The University of Pennsylvania, 3400 Spruce Street, Silverstein Pavilion 3rd Floor, Philadelphia, PA, USA 19104.

Background: Freehand bedside ventriculostomy placement can result in catheter malfunction requiring a revision procedure and cause significant patient morbidity. We performed a single-center retrospective review to assess factors related to this complication.

Methods: Using an administrative database and chart review, we identified 101 first-time EVD placements performed at the bedside. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.196DOI Listing
November 2018
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Management of intracranial haemorrhage, unruptured aneurysms and arteriovenous malformations during and after pregnancy.

Curr Opin Neurol 2019 Feb;32(1):36-42

Medicina Vascolare e D'Urgenza-Stroke Unit, Ospedale Santa Maria della Misericordia, Università di Perugia, Perugia, Italy.

Purpose Of Review: The absolute risk of pregnancy-associated intracranial haemorrhage (ICH) has been reported to be relatively low and often associated with high risks of life-long disabilities and mortality. The aim of this narrative review was obtaining a better understanding of the current management practices for ICH, unruptured aneurysms and/or arteriovenous malformations during pregnancy, as well as the effects of future pregnancies, and the uses of oral contraceptive or HRT.

Recent Finding: General guidelines for the management of ICH are used for pregnant women but additional expedient and thorough evaluation of foetal viability and its gestational age are requested. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000643DOI Listing
February 2019
1 Read