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Neuro Endocrinol Lett 2019 Feb 12;39(7):489-495. Epub 2019 Feb 12.

Introduction: The clinical characteristics of subacute thyroiditis (SAT) has been changing in recent years. There are more and more patients with painless SAT, and more cases of SAT with elevated levels of anti-thyroid antibodies were reported. The aim of the study was to evaluate the clinical characteristics of SAT patients with special regard to the differences between the previously described and currently observed features of the disease. Read More

Int J Mol Sci 2019 Mar 3;20(5). Epub 2019 Mar 3.

Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, 93-338 Lodz, Poland.

The frequency of recurrence of subacute thyroiditis (SAT) is rather high, reaching 20⁻30%. The reason for SAT relapse is still unknown. Recently, we have demonstrated the association between SAT and the presence of HLA-B*18:01, DRB1*01, and C*04:01, apart from the previously known HLA-B*35. Read More

Endocr J 2019 Feb 27. Epub 2019 Feb 27.

Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.

Graves' Disease is a representative autoimmune thyroid disease that presents with hyperthyroidism. Emerging evidence has shown the involvement of lysophosphatidic acid (LPA) and its producing enzyme, autotaxin (ATX), in the pathogenesis of various diseases; among them, the involvement of the ATX/LPA axis in some immunological disturbances has been proposed. In this study, we investigated the association between serum ATX levels and Graves' disease. Read More

Horm Metab Res 2019 Feb 21. Epub 2019 Feb 21.

Medical University Department, Division of Endocrinology, Diabetes & Metabolism, Kantonsspital Aarau, Aarau, Switzerland.

Early diagnosis of thyroid disorders is key to further treatment. We assessed the ability of a high-throughput proton NMR metabolomic profile to distinguish disease type amongst of Graves' disease (n=87), Hashimoto's thyroiditis (n=17), toxic goiter (n=11), and autoimmune thyroiditis [i. e. Read More

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):867

[This corrects the article on p. 713 in vol. 22, PMID: 30294587. Read More

Comput Intell Neurosci 2019 15;2019:6212759. Epub 2019 Jan 15.

Nuclear Medicine Department, Heilongjiang Provincial Hospital, Harbin 150030, China.

Thyroid disease has now become the second largest disease in the endocrine field; SPECT imaging is particularly important for the clinical diagnosis of thyroid diseases. However, there is little research on the application of SPECT images in the computer-aided diagnosis of thyroid diseases based on machine learning methods. A convolutional neural network with optimization-based computer-aided diagnosis of thyroid diseases using SPECT images is developed. Read More

Front Endocrinol (Lausanne) 2019 23;10. Epub 2019 Jan 23.

Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.

Since 1977 the susceptibility to SAT has been known to be HLA-B35-related in ~70% of patients. Recently it has been demonstrated that SAT is associated with the presence of HLA-B18:01 and DRB101, as well as with HLA-C04:01. The association between the type of genetic SAT background and sonographic pattern of the disease has never been analyzed. Read More

BMC Musculoskelet Disord 2019 Jan 5;20(1):10. Epub 2019 Jan 5.

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.

Background: Klippel-Trenaunay syndrome (KTS) is a rare congenital syndrome characterized by the triad of venous varicosities, capillary malformations and limb hypertrophy. However, KTS may rarely occur in combination with kyphoscoliosis.

Case Presentation: We presented an 18-year-old female with KTS and kyphoscoliosis. Read More

BMJ Case Rep 2018 Dec 18;11(1). Epub 2018 Dec 18.

Department of Aviation Medicine, Evans US Army Hospital, Fort Carson, Colorado, USA.

Subacutethyroiditis is a self-limited inflammatory condition commonly of viral aetiology, that manifests through phases of thyroid hormone changes over a 6-8 month period. A 24-year-old active duty military man, undergoing treatment for recurrent infection, presented for clinical evaluation and was found to have a thyroid stimulating hormone level of 0.003 mg/dL. Read More

Case Rep Endocrinol 2018 30;2018:3210317. Epub 2018 Oct 30.

Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.

Subacute thyroiditis is an inflammatory disorder of the thyroid. Graves' disease is an autoimmune thyroid disease in which thyroid hormones are overproduced. Here we present a rare case of thyrotoxicosis due to the simultaneous occurrence of both diseases. Read More

Case Rep Endocrinol 2018 25;2018:5041724. Epub 2018 Oct 25.

Monmouth Medical Center, Long Branch, NJ 07740, USA.

An 80-year-old Caucasian male presented with fever of 3-week duration. Outpatient workup for infectious etiologies was negative and due to persistent fever, he was hospitalized for further evaluation of fever of unknown origin (FUO). Physical examination and laboratory studies remained unremarkable; however a follow-up CT scan of chest, abdomen, and pelvis with contrast done to rule out malignancy as an underlying cause of FUO revealed heterogeneous thyroid gland with surrounding hazy changes suggestive of thyroiditis. Read More

Discov Med 2018 09;26(142):67-77

Department of Endocrinology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.

Tumor necrosis factor alpha (TNF-α) regulates the expression of proinflammatory cytokines and apoptosis in thyroids. miR-155-5p is upregulated in circulating microvesicles in patients with autoimmune thyroiditis. However, the function and molecular mechanisms of TNF-α and miR-155-5p in the initiation and progression of subacute thyroiditis are largely unknown. Read More

Indian J Nucl Med 2018 Oct-Dec;33(4):306-311

Departments of Nuclear Medicine, Endocrinology, Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

Introduction: Sub-acute thyroiditis possibly caused by a viral infection of thyroid gland is associated with a surge in thyroxine levels of the patient. Women in the younger age group are affected more than men. Markedly decreased radioactive iodine thyroid uptakes in a setting of thyrotoxicosis associated with elevated thyroxine levels and reduced thyroid stimulating hormone levels usually clinches the diagnosis. Read More

Semergen 2019 Jan - Feb;45(1):e1-e2. Epub 2018 Oct 11.

Centro de Salud Canillejas, Madrid, España.

Indian J Endocrinol Metab 2018 Sep-Oct;22(5):713-714

Department of Endocrinology, Apex Hospital, Rohtak, Haryana, India.

Presse Med 2018 Sep 28;47(9):746-756. Epub 2018 Sep 28.

CHU Clermont-Ferrand, service d'endocrinologie, diabétologie et maladies métaboliques, 63003 Clermont-Ferrand, France; Laboratoire GReD : UMR université Clermont Auvergne-CNRS 6293, Inserm U1103, BP 10448, 63177 Aubiere, France.

Amiodarone, a benzofuranic iodine-rich pan antiarrhythmic drug, is frequently associated with thyroid dysfunction. This side effect is heterogeneous and unpredicted, motivating regular evaluation of thyroid function tests. In contrary to hypothyroidism, amiodarone-induced thyrotoxicosis (AIT) is a challenging situation owing to the risk of deterioration of the general and cardiac status of such debilitating patients. Read More

Turk J Anaesthesiol Reanim 2018 Sep 1;46(5):402-405. Epub 2018 Sep 1.

Department of Radiology, Health Scienses University Ümraniye Training and Research Hospital İstanbul, Turkey.

Hashimoto encephalopathy (HE) is a steroid-responsive, acute or subacute encephalopathy, characterised by autoimmune thyroiditis associated with elevated antithyroid antibody titres. An 11-year-old girl was admitted to the Department of Paediatrics with generalised tonic-clonic seizures, left facial paralysis and right hemiparesis. Ceftriaxone and acyclovir were applied, and methyl prednisolone 2 mg kg day was administered orally. Read More

Oxf Med Case Reports 2018 Oct 24;2018(10):omy073. Epub 2018 Sep 24.

Visby Lasarett, Visby, Gotland, Sweden.

Being treatable, steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), or Hashimoto's encephalopathy, should be distinguished from untreatable conditions. Our patient was a previously healthy 89-year-old man, who presented with cognitive and balance deterioration over several months. His cerebrospinal fluid (CSF) examination was positive for protein 14-3-3 but no other test suggested Creutzfeldt-Jacob disease. Read More

Radiol Oncol 2018 Sep 11;52(3):257-262. Epub 2018 Sep 11.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Background The association of subacute thyroiditis (SAT) and papillary thyroid carcinoma is a rare finding. In this study, we aimed to investigate the prevalence of differentiated thyroid cancer in a cohort of patients followed with the diagnosis of SAT. Patients and methods We retrospectively screened medical records of Endocrinology and Metabolism outpatient clinic in the past 20 years for patients with SAT. Read More

Tremor Other Hyperkinet Mov (N Y) 2018 9;8:585. Epub 2018 Aug 9.

Neurology Division, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Myoclonus and tremor are common movement disorder phenomenologies in steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT). Pure ataxia without encephalopathy has rarely been reported.

Case Report: We report 21- and 40-year-old females who presented with subacute pure ataxia without encephalopathy. Read More

Intern Med J 2018 09;48(9):1160-1162

Department of Cardiovascular Medicine, Karatsu Red Cross Hospital, Karatsu, Japan.

Int J Endocrinol 2018 4;2018:4836736. Epub 2018 Jun 4.

Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China.

Background: The results of previous studies on the usefulness of free triiodothyronine (FT3) to free thyroxine (FT4) are controversial. We investigated the usefulness of FT3, FT4, and FT3/FT4 ratio in differentiating Graves' disease (GD) from destructive thyroiditis.

Methods: A total of 126 patients with untreated GD, 36 with painless thyroiditis, 18 with painful subacute thyroiditis, and 63 healthy controls, were recruited. Read More

J Clin Oncol 2018 Jun 15:JCO2017773184. Epub 2018 Jun 15.

Jinhyun Cho, Inha University Hospital, Inha University School of Medicine, Incheon; Hae Su Kim, Veterans Health Service Medical Center; Bo Mi Ku, Yoon-La Choi, Joungho Han, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, and Myung-Ju Ahn, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Korea; and Razvan Cristescu, Merck Research Laboratories, Boston, MA.

Purpose Limited treatment options exist for patients with thymic epithelial tumor (TET) whose disease progresses after platinum-based chemotherapy. We conducted a phase II study of pembrolizumab in patients with TET to evaluate its efficacy and safety. Methods Patients with histologically confirmed TET whose disease progressed after at least one line of platinum-based chemotherapy were eligible for the study. Read More

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618778709. Epub 2018 May 25.

Mount Sinai Medical Center, Miami Beach, FL, USA.

Thyroid abscess is an uncommon infectious pathology. The thyroid is highly resistant to infection due to high iodine content, capsular encasement, and rich vascularity. Acute suppurative thyroiditis represents <1% of thyroid diseases that could potentially become a life-threatening endocrine emergency. Read More

Case Rep Med 2018 26;2018:5098712. Epub 2018 Mar 26.

Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.

Acute suppurative thyroiditis (AST) is an uncommon, potentially life-threatening cause of a rapidly enlarging neck mass. It may present similarly to subacute thyroiditis, a relatively benign and self-limiting condition. We report a case of AST in an adult intravenous (IV) drug user with a preexisting goiter who presented with a left forearm abscess that grew methicillin-sensitive . Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 May;53(5):381-384

Department of Otorhinolaryngology Head and Neck Surgery, Kunming Children's Hospital; Head and Neck Disease Treatment Center, Kunming 650228, China.

To discuss the misdiagnosis of pyriform sinus fistula and to better understand this kind of illness. The analysis was based on twenty-eight patients with congenital pyriform sinus fistula aged from 11 months to 14 years, with the median age of 5 years, and who were surgically treated from January 2013 to January 2017 in Kunming Children's Hospital.Twenty patients were misdiagnosed in other hospital. Read More

Lakartidningen 2018 04 13;115. Epub 2018 Apr 13.

Skanes universitetssjukhus Malmo - Department of Endocrinology Malmo, Sweden Skanes universitetssjukhus Malmo - Department of Endocrinology Malmo, Sweden.

Subacute thyroiditis is a common inflammatory disorder of the thyroid gland, possibly of viral etiology, that typically presents with neck pain, fever and tenderness on palpation of the thyroid gland. Graves' disease is an autoimmune thyroid disorder caused by stimulation of the thyroid gland by thyrotropin receptor antibodies (TRAb). The development of Graves´ disease and subacute thyroiditis simultaneously is an uncommon condition and only a few cases have been reported. Read More

Clin Imaging 2018 May - Jun;49:187-192. Epub 2018 Mar 29.

Department of Ultrasonography, Baoji Central Hospital, Baoji 721008, China.

Purpose: The aim of this study is to discuss the value of ultrasound-based shear wave™ elastography (SWE) in diffuse thyroid disease (DTD).

Method: Thyroid stiffness in 154 patients with DTD and 30 normal subjects was measured by SWE. The serum indicators of all subjects were detected. Read More

Recent Pat Endocr Metab Immune Drug Discov 2017 ;11(1):22-31

Departments of Medicine, Community Health Sciences, and Oncology, The University of Calgary, Calgary, Alberta, Canada.

Background: Uncontrolled thyrotoxicosis, especially in early infancy, may cause irreversible damage to the central nervous system as well as profound effects on the function of many organs. Thyrotoxicosis has multiple etiologies and treatment depends on the underlying etiology. An accurate diagnosis is essential so that appropriate treatment can be initiated without undue delay. Read More

Br J Surg 2018 05 26;105(6):677-685. Epub 2018 Mar 26.

Department of General, Vascular and Visceral Surgery, Martin Luther University of Halle-Wittenberg, Halle an der Saale, Germany.

Background: Surgical approaches to autoimmune thyroid disease are currently hampered by concerns over postoperative complications. Risk profiles and incidences of postoperative complications have not been investigated systematically, and studies with sufficient power to show valid data have not been performed.

Methods: A prospective multicentre European study was conducted between July 2010 and December 2012. Read More

J Med Case Rep 2018 Feb 23;12(1):51. Epub 2018 Feb 23.

Department of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.

Background: Pyrexia of unknown origin is a difficult and challenging problem for the physician. Endocrine disorders, such as subacute thyroiditis, rarely present with pyrexia of unknown origin. Subacute thyroiditis can have a broad spectrum of clinical presentations including fever and biochemical thyrotoxicosis without overt signs or symptoms. Read More

Int J Dermatol 2018 Jul 20;57(7):869-871. Epub 2018 Feb 20.

Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Head Neck Pathol 2018 Feb 9. Epub 2018 Feb 9.

Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, USA.

Subacute thyroiditis (SAT) is a self-limiting inflammatory condition of the thyroid gland in which multinucleated giant cells constitute a key histological finding. SAT is generally a clinical diagnosis and consequently its histological features are rarely encountered by pathologist. Herein, we present a case that exemplifies the characteristic clinical and pathological features of this entity. Read More

Nucl Med Mol Imaging 2018 Feb 17;52(1):82-84. Epub 2016 Oct 17.

Department of Nuclear Medicine, Wonkwang University School of Medicine and Institute of Wonkwang Medical Science, 895, Muwang-ro, Iksan, 54538 Republic of Korea.

F-18 fluorodeoxyglucose (FDG) is a highly influential radiotracer that provides valuable information in many cancer types. However, the normal biodistribution of F-18 FDG is often variable and can be altered by intrinsic or iatrogenic factors. We report a case of diffuse symmetrically increased skeletal muscle uptake and relatively decreased hepatic uptake on F-18 FDG PET/CT in a 57-year-old female with pulmonary adenocarcinoma. Read More

J Clin Ultrasound 2018 Sep 8;46(7):497-500. Epub 2018 Jan 8.

Department of Radiation Oncology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea.

Amyloid goiter (AG) is defined as the diffuse enlargement of the thyroid gland resulting from extensive amyloid deposition. Imaging findings in AG may vary depending on the amount of amyloid and fat deposition. A few case reports of AG with clinically subacute thyroiditis (SAT)-like syndrome have been published. Read More

Ann Clin Lab Sci 2017 Sep;47(5):620-624

Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, USA.

Background: Granulomatous disease in the thyroid gland has been linked to viral, bacterial and autoimmune etiologies. The most common granulomatous disease of the thyroid is subacute granulomatous thyroiditis, which is presumed to have a viral or post-viral inflammatory cause. Bacterial etiologies include tuberculosis, actinomycosis, and nocardiosis, but are extremely rare. Read More

J Clin Diagn Res 2017 Aug 1;11(8):EC09-EC11. Epub 2017 Aug 1.

Assistant Professor, Department of Pathology, SMIMS, Gangtok, Sikkim, India.

Introduction: De Quervain's Thyroiditis (DQT) is a self limiting inflammatory disease of the thyroid gland that presents with pain and sore throat. Although the diagnosis is usually made clinically, Fine Needle Aspiration (FNA) may provide assistance, particularly in excluding other thyroid lesions.

Aim: The objective of this study was to reveal the cytological characteristics of DQT. Read More

Orv Hetil 2017 Oct;158(39):1550-1554

I. Belgyógyászati Osztály, Pest Megyei Flór Ferenc Kórház Kistarcsa, Semmelweis tér 1., 2143.

65 years old male patient received 4 mg/day methylprednisolone baseline therapy and 50 mg/week etanercept treatment for 5 years due to rheumatoid arthritis. The patient experienced pain in neck, and developed weakness, fever and dysphagia. He had normal blood count but accelerated erythrocyte sedimentation rate (88 mm/hour), elevated CRP (49. Read More

Clin Lab 2017 Sep;63(9):1487-1492

Background: Platelet parameters have been studied in many diseases. This study explored the changes of mean platelet volume (MPV) and platelet count (PLT) in subacute thyroiditis (SAT).

Methods: We retrospectively studied 44 patients with SAT and 45 healthy individuals. Read More

Endocr J 2017 Oct 2;64(10):955-961. Epub 2017 Aug 2.

Kuma Hospital, Center for Excellence in Thyroid Care, Kobe 650-0011, Japan.

It is generally believed that the detection of thyroid peroxidase antibodies (TPOAb) is superior to that of thyroglobulin antibodies (TgAb) for the diagnosis of Hashimoto's thyroiditis. However, limited data are available on the comparison of TgAb and TPOAb prevalence as a diagnostic measurement for Hashimoto's thyroiditis using sensitive immunoassays. We herein used five different current immunoassay kits (A-E) to compare the prevalence of TgAb and TPOAb in Hashimoto's thyroiditis (n = 70), Graves' disease (n = 70), painless thyroiditis (n = 50), and healthy control subjects (n = 100). Read More

Medicine (Baltimore) 2017 Jul;96(30):e7535

aPET Imaging Center, Asahi General Hospital bDepartment of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba cDepartment of Diagnostic Radiology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo dDepartment of Radiology, Asahi General Hospital, Chiba, Japan.

Background: In addition to its established role in oncologic imaging, F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) is useful for the assessment of inflammatory activity. However, subacute thyroiditis (SAT) in thyrotoxicosis is rarely detected during these scans.

Case: A 66-year-old man with SAT in thyrotoxicosis demonstrated symptoms of transient fatigue, headache, and fever, without typical neck pain. Read More

Ann Otol Rhinol Laryngol 2017 Sep 18;126(9):625-633. Epub 2017 Jul 18.

1 Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University, College of Medicine, Seoul, Korea.

Purpose: The purpose of this study was to evaluate the predictive value of ultrasonography (US) patterns based on the 2015 American Thyroid Association (ATA) guidelines for malignancy in atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) nodules.

Methods: From January 2014 to August 2015, 133 thyroid nodules that were initially diagnosed as AUS/FLUS on fine needle aspiration (FNA) were included in this study. Each nodule was assigned a category with US patterns defined by the ATA guidelines. Read More

J Med Ultrason (2001) 2018 Jan 27;45(1):81-87. Epub 2017 Jun 27.

Department of Radiological Sciences, Tokyo Metropolitan University Graduate School of Human Health Sciences, Tokyo, Japan.

Purpose: The incidences of perithyroidal lymph nodes (PTLNs) in benign thyroid diseases were investigated.

Methods: A total of 108 patients were divided into 36 with benign thyroid nodules, 33 with Hashimoto's thyroiditis, 14 with Graves' disease, 10 with hypothyroidism of undetermined etiology, nine with silent thyroiditis, and six with subacute thyroiditis. We assessed the relationships among PTLNs and these groups, thyroid volume, thyroid parenchyma echogenicity, and anti-thyroid-stimulating hormone receptor, anti-thyroglobulin, and anti-thyroid peroxidase antibodies (TRAb, TgAb, and TPOAb). Read More

Indian J Pathol Microbiol 2017 Apr-Jun;60(2):282-284

Department of Otorhinolaryngology, Government Medical College Hospital, Chandigarh, India.

Acute suppurative thyroiditis (AST) is an uncommon condition, in the patients with preexisting thyroid disease or immunosuppression. The most common cause of AST is bacterial, and the most common bacteria are Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Klebsiella species. Due to various complications such as septicemia, septic thrombophlebitis, necrotizing mediastinitis, or pericarditis, prompt diagnosis and treatment are the keys to reduce mortality and morbidity. Read More

Nucl Med Mol Imaging 2017 Jun 24;51(2):169-177. Epub 2016 Nov 24.

Department of Nuclear Medicine, Kyungpook National University School of Medicine/Hospital, 130 Dongdeok-ro, Jung-gu, Daegu, Republic of Korea 700-721.

Purpose: Although Sjögren's syndrome (SS) is the most common disease causing xerostomia, autoimmune thyroid diseases can also affect the salivary glands. The aim of our study was to estimate the prevalence of thyroid diseases (TD) in subjects with symptoms of xerostomia and evaluate the efficacy of salivary gland scintigraphy (SGS) in the detection of TD in patients with SS and without SS.

Methods: We retrospectively reviewed the SGS findings of 173 subjects (men:women, 29:144) with symptoms of xerostomia. Read More

Int J Surg Case Rep 2017 8;33:112-114. Epub 2017 Apr 8.

Bioscience Center, Goran Street, Sulaimani, Kurdistan Region, Iraq; Faculty of Science and Health, Clinical Psychology Department, Koya University, Danyal Mitran Street, Koya, Kurdistan Region, Iraq.

Introduction: Subacute thyroiditis is a self-limited, inflammatory viral thyroid disease which presents with neck pain, usually accompanied by systemic symptoms. On the other hand, thyroid storm is a clinical condition of severe sudden hyperthyroidism accompanied by physiologic de-compensation. We presented a 29-year-old male with features of subacute thyroiditis and thyroid storm who is the third reported case managed by steroid, beta-blocker and analgesics. Read More

Neuro Endocrinol Lett 2017 Jan;37(8):540-542

Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

A 26-year-old Japanese woman presented with adrenal insufficiency, and treatment was started with cortisone and fludrocortisone in 1975. A few years later, she presented with hypoparathyroidism and was diagnosed with autoimmune polyendocrine syndrome type I (APS I), and treatment with calcium and alfacalcidol was started. She was found to have subacute thyroiditis and relative adrenal failure in 2006. Read More

Front Endocrinol (Lausanne) 2016 24;7:150. Epub 2017 Jan 24.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Aviv, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Tel-Aviv University, Tel-Aviv, Israel.

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), presented by Shoenfeld and Agmon-Levin in 2011, is an entity that incorporates diverse autoimmune conditions induced by the exposure to various adjuvants. Adjuvants are agents that entail the capability to induce immune reactions. Adjuvants are found in many vaccines and used mainly to increase the response to vaccination in the general population. Read More

Clin Med (Lond) 2017 Feb;17(1):86-87

Sultan Qaboos University Hospital, Al Khod, Muscat, Oman.

Fever of unknown origin (FUO) is sometimes a diagnostic dilemma for clinicians. Endocrine causes reported in the literature include subacute thyroiditis, thyrotoxicosis, adrenal insufficiency and pheochromocytoma. Among these, subacute thyroiditis is often overlooked as it can occasionally lack typical symptoms. Read More