33,651 results match your criteria Subacute Nodular Migratory Panniculitis Vilanova Disease


The effect of task-oriented electromyography-triggered electrical stimulation of the paretic wrist extensors on upper limb motor function early after stroke: a pilot randomized controlled trial.

Int J Rehabil Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Physical Medicine and Rehabilitation, University of Health Science, Diskapi Yildirim Beyazit Research and Training Hospital, Ankara, Turkey.

The combined effect of task-oriented motor training and electromyography (EMG)-triggered electrical stimulation (ES) has been examined in chronic stroke, but there are no published reports in patients with early stroke. Therefore, the purpose of this study was to determine the short-term and long-term effects of task-oriented EMG-triggered ES on upper limb motor function in acute/subacute stroke. Twenty-seven patients with stroke within the first 3 months after stroke onset were randomly allocated to an experimental group and a control group. Read More

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December 2018
1 Read

Association of Noninfectious Pneumonia With Ustekinumab Use.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Office of Surveillance and Epidemiology, Division of Pharmacovigilance, FDA Center for Drug Evaluation and Research, Silver Spring, Maryland.

Importance: The US Food and Drug Administration (FDA) conducts ongoing public health safety surveillance for drug and therapeutic biologic products. Identifying cases of acute and subacute noninfectious pneumonia supports the public health mission of the FDA.

Objective: To identify and analyze postmarketing cases of noninfectious pneumonia associated with ustekinumab use. Read More

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December 2018

Subarachnoid extension of lobar hemorrhage on acute/subacute MRI is associated with cerebral amyloid angiopathy criteria.

Acta Neurol Belg 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurology, CHU Nîmes, Hôpital Caremeau, Nîmes University Hospital, 4, Rue du Pr Debré, 30029, Nîmes Cedex 4, France.

Subarachnoid hemorrhage extension (SAHE) in the acute phase of cerebral amyloid angiopathy (CAA)-related lobar hemorrhage (LH) assessed by CT is very frequent. Recently, SAHE, together with finger-like projections on CT and ApoE4, has been used in a prediction model for histopathologically proven CAA showing excellent discrimination. Our aim was to analyze SAHE on MRI in the acute and subacute phase of LH in patients with and without associated hemorrhagic features supportive of CAA (i. Read More

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December 2018

Chronic Inflammatory Demyelinating Polyneuropathy With Concurrent Membranous Nephropathy: An Anti-paranode and Podocyte Protein Antibody Study and Literature Survey.

Front Neurol 2018 27;9:997. Epub 2018 Nov 27.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Several case reports have described the concurrence of chronic inflammatory demyelinating polyneuropathy (CIDP) and membranous nephropathy (MN). The presence of autoantibodies against podocyte antigens phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain containing 7A (THSD7A) in MN suggests an autoimmune mechanism. Some CIDP patients also harbor autoantibodies against paranodal proteins such as neurofascin 155 (NF155) and contactin-1 (CNTN1). Read More

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November 2018

Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system.

Int J Nanomedicine 2018 21;13:7819-7834. Epub 2018 Nov 21.

Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China,

Background: The harmful effects following the release of nanomaterials into environment are of great concern today.

Purpose: In this study, subacute effect due to co-exposure to low-dose silica nanoparticles (SiNPs) and lead acetate (Pb) on cardiovascular system was detected in Sprague Dawley male rats.

Materials And Methods: Histopathological and ultrastructural changes of heart, aortic arch and abdominal aorta were detected. Read More

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November 2018

Septic embolization of left and right coronary arteries resulting in sudden death: A rare complication of infective endocarditis.

J Cardiol Cases 2014 Jul 1;10(1):22-24. Epub 2014 May 1.

Teaching Hospital Kandy, Kandy, Sri Lanka.

Bacterial endocarditis gives rise to a variety of complications due to local tissue damage, immunological phenomena, and embolic phenomena. Only a small number of cases of coronary embolization have been reported in infective endocarditis patients. This is a case of subacute bacterial endocarditis in a postpartum mother complicated by fatal left and right coronary artery embolization. Read More

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A case of coronary artery disease with antiphospholipid syndrome that showed repeated stent thrombosis.

J Cardiol Cases 2011 Oct 27;4(2):e80-e86. Epub 2011 Jul 27.

Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

A 55-year-old man with severe chest pain was hospitalized for acute coronary syndrome. Coronary angiography revealed total occlusion of his left anterior descending coronary artery, which was successfully recanalized by percutaneous coronary intervention (PCI). However, the patient subsequently experienced subacute stent thrombosis, restenosis in the stent, and frequent thrombosis in PCI toward restenosis. Read More

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October 2011

Subacute coronary occlusion with dissection of the sinus of Valsalva after percutaneous coronary intervention in the right coronary artery.

J Cardiol Cases 2011 Feb 14;3(1):e13-e16. Epub 2010 Dec 14.

Division of Cardiology, East Medical Center Higashi Municipal Hospital City of Nagoya, 1-2-23 Wakamizu, Chikusa-ku, Nagoya 464-8547, Japan.

Subacute coronary occlusion due to dissection of the right coronary sinus of Valsalva after coronary stenting at the proximal portion of the right coronary artery is described. A bail-out procedure was successfully performed by stent deployment at the ostium of the right coronary artery with its proximal edge protruding into the ascending aorta. However, the patient died of multiple organ failure due to worsened renal failure and cardiogenic shock. Read More

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February 2011

Recurrent very late thrombosis of drug-eluting stent: Optical coherence tomography findings.

J Cardiol Cases 2010 Dec 10;2(3):e166-e169. Epub 2010 Aug 10.

Division of Cardiology, Nippon Medical School, Tokyo, Japan.

Very late stent thrombosis (VLST) after implantation of a drug-eluting stent (DES) is a rare but catastrophic complication and the mechanisms are not completely understood. We describe a 76-year-old patient with recurrent VLST of DES that developed at 13 and 23 months after the initial catheter procedure of DES implantation under the cessation of dual antiplatelet therapy. Optical coherence tomography (OCT) observation revealed small stent area of a DES. Read More

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December 2010

Subacute ruminal acidosis suppressed the expression of MCT1 in rumen of cows.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin, China.

Subacute ruminal acidosis (SARA) is characterized by the depression of ruminal pH and an increase in the concentrations of short-chain fatty acids (SCFAs) and lipopolysaccharide (LPS) in the rumen of cows. The onset of SARA was linked to the accumulation of SCFAs. However, the mechanism of SCFAs transport is unknown. Read More

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December 2018
2 Reads

Gamma Knife radiosurgery for intravestibular and intracochlear schwannomas.

Acta Neurochir (Wien) 2018 Dec 8. Epub 2018 Dec 8.

Centre Hospitalier Universitaire Vaudois (CHUV), Neurosurgery Service and Gamma Knife Center, Rue du Bugnon 44-46, BH-08, CH-1011, Lausanne, Switzerland.

Background: Schwannomas of the VIIIth cranial nerve are benign tumours, with vast majority occurring in vestibular division. Rarely, they can also arise from distal branches of cochlear, superior or inferior vestibular. We review our experience with Gamma Knife radiosurgery (GKR), as first intention treatment for intracochlear (ICS) and intravestibular (IVS) schwannomas. Read More

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December 2018
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Comparative study of intestinal malrotation in infant, children, and adult in a tertiary care center in India.

Indian J Gastroenterol 2018 Dec 7. Epub 2018 Dec 7.

Department of Gastroenterology, Patna Medical College and Hospital, Ashok Rajpath Road, Patna University Campus, Patna, 800 001, India.

Background: Intestinal malrotation (IM) is an uncommon condition and has varied presentation in different age groups. The study was aimed to evaluate differences in the clinical presentation, diagnosis, treatment, and outcome of IM in infants, children, and adults.

Methods: Data were collected from records of 79 patients with IM. Read More

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December 2018
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Curcumin and quercetin synergistically attenuate subacute diazinon-induced inflammation and oxidative neurohepatic damage, and acetylcholinesterase inhibition in albino rats.

Environ Sci Pollut Res Int 2018 Dec 8. Epub 2018 Dec 8.

Department of Zoology, Science College, King Saud University, Riyadh, Saudi Arabia.

The ubiquitous use of diazinon (DZN, an organophosphorus insecticide) has increased the probability of occupational, public, and the ecosystem exposure; these exposures are linked to negative health outcomes. The flavonoids curcumin (CUR) and quercetin (QUE) exert significant anti-inflammatory and antioxidant activities against toxicants, including insecticides. However, it is unclear whether their combination enhances these activities. Read More

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December 2018

Preliminary Study of Dynamic Cerebral Autoregulation in Acute Ischemic Stroke: Association With Clinical Factors.

Front Neurol 2018 26;9:1006. Epub 2018 Nov 26.

Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China.

Dynamic cerebral autoregulation (dCA) is probably impaired in the acute and even subacute phases after acute ischemic stroke (AIS); however, the relationship between relevant clinical factors and dCA after AIS has not been investigated. The identification of possible determinants may therefore provide potential therapeutic targets to improve dCA in AIS. This study enrolled 67 consecutive patients diagnosed with AIS within 3 days from symptom onset. Read More

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November 2018

Paraneoplastic Cerebellar Degeneration Associated With Ovarian Adenocarcinoma: A Case Report and Review of Literature.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):311-314

Department of Neurosciences, Institute of Neurosciences/Internal Medicine, Indraprastha Apollo Hospitals, New Delhi, India.

Paraneoplastic syndromes are a rare heterogeneous group of disorders that are indicators of the underlying occult malignancy. Subacute cerebellar ataxia in a patient with a known cancer is often due to metastatic invasion or other complications of the cancer, such as infection, coagulopathy, metabolic and nutritional deficits, or side effects of treatment. When tumor- and treatment-related causes have been excluded, the patient is considered to suffer from paraneoplastic cerebellar degeneration (PCD). Read More

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December 2018

Abnormal DNA Methylation in Thoracic Spinal Cord Tissue Following Transection Injury.

Med Sci Monit 2018 Dec 8;24:8878-8890. Epub 2018 Dec 8.

Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China (mainland).

BACKGROUND Spinal cord injury (SCI) is a serious disease with high disability and mortality rates, with no effective therapeutic strategies available. In SCI, abnormal DNA methylation is considered to be associated with axonal regeneration and cell proliferation. However, the roles of key genes in potential molecular mechanisms of SCI are not clear. Read More

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December 2018

Faciobrachial dystonic seizures expressed as epileptic spasms, followed by focal seizures in anti-LGI1 encephalitis: a video-polygraphic study.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Epilepsy Centre - Clinic of Nervous System Diseases, Riuniti Hospital, Foggia, Italy.

The origin of faciobrachial dystonic seizures in anti-LGI1 encephalitis is controversial due to a lack of neurophysiological characterization. We report a 68-year-old man with subacute anterograde memory loss and involuntary faciobrachial movements. Video-polygraphic recordings disclosed repetitive events characterized by sudden, short contraction of the upper limbs and ipsilateral hemiface. Read More

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December 2018

Moderate Asymptomatic Subacute Eosinophilia Secondary to Simvastatin Therapy.

J Investig Allergol Clin Immunol 2018 Dec;28(6):434-436

Clinical Analysis Laboratory, Policlínico Valencia, Valencia, Spain.

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December 2018

Effects of ammonia nitrogen on gill mitochondria in clam Ruditapes philippinarum.

Environ Toxicol Pharmacol 2018 Dec 3;65:46-52. Epub 2018 Dec 3.

Biology School of Yantai University, Yantai 264005, PR China.

Ammonia nitrogen exposure has been found to significantly increase the early apoptosis rates of gill cells, affect the contents of ATP and disturb expressions of calcium-related genes in clam Ruditapes philippinarum. Mitochondria are the centers for energy production, initiation of apoptosis and calcium signal regulation. It is hypothesized that gill mitochondrion is a target organelle for the ammonia nitrogen. Read More

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December 2018

Subacute Elevation of Plasma Level of Caspase-Cleaved Cytokeratin-18 is Associated with Hemorrhagic Transformation and Functional Outcome in Ischemic Stroke.

J Stroke Cerebrovasc Dis 2018 Dec 5. Epub 2018 Dec 5.

Department of Neurology, University of Pecs, Pecs, Hungary. Electronic address:

Background: Caspase-cleaved cytokeratin-18 (CCCK-18) is an apoptosis marker. Here, we analyzed the relationship between plasma level of CCCK-18 in the acute and subacute stage of ischemic stroke and early and late functional outcome. Besides, correlation among CCCK-18 and complications, such as hemorrhagic transformation (HT) were also explored. Read More

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December 2018

The Unstable Spine: A Surgeon's Perspective.

Semin Ultrasound CT MR 2018 Dec 13;39(6):618-629. Epub 2018 Oct 13.

Department of Orthopedic Surgery & Rehabilitation, University of Nebraska Medical Center, Omaha, NE.

Instability of the spine is a complex clinical entity that exists on a wide spectrum encompassing many aspects of spinal pathology including traumatic, neoplastic, infectious, and degenerative processes. The importance of determining stability is paramount in the decision-making process regarding the need for operative or nonoperative care. Defining clinical instability can be a challenging and requires careful attention to the pathology involved, findings of necessary imaging, and a thorough clinical exam. Read More

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December 2018

A 57-Year-Old Man With Subacute Progressive Hemoptysis and Fevers.

Chest 2018 Dec;154(6):e181-e185

Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:

Case Presentation: A 57-year-old man was admitted for 1 month of accelerating hemoptysis and hematemesis. Two weeks earlier, he first presented with fevers and hemoptysis of 2 weeks' duration and was diagnosed with community-acquired pneumonia treated with 5 days of ceftriaxone and azithromycin. He improved and was discharged, but his hemoptysis recurred 1 day after discharge and progressed over 9 days, leading to the present admission. Read More

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December 2018
1 Read

A British pathologist and child neurologist who described familial dementing disease and the neuropathology of subacute combined degeneration.

J Hist Neurosci 2018 Dec 11:1-10. Epub 2018 Dec 11.

d Samuel J. Wood Library, Weil Cornell Medicine , New York , New York , USA.

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December 2018

Influence of subacute physical exercise on medium- and long-chain fatty acid profile in serum of individuals with overweight.

Nutr Hosp 2018 Dec 3;35(6):1310-1315. Epub 2018 Dec 3.

Faculdade Adventista da Bahia.

Objective: to test the hypothesis that acute physical exercise would change the fatty acids in the serum of individuals with increased body weight.

Method: sixty-six sedentary women with excess weight were included in the sample (BMI = 29.6 ± 4. Read More

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December 2018

Pulmonary embolectomy in a case of subacute pulmonary embolism, with previous unsuccessful fibrinolysis

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):418-423. Epub 2018 Nov 30.

Universidad Nacional Autónoma de México, Facultad de Medicina, División de Estudios de Posgrado. Ciudad de México, México

Background: Pulmonary embolism is a potentially fatal heart condition that requires prompt restoration of blood flow in the pulmonary vascular bed and prevention of recurrent events. Mortality is associated to the degree of hemodynamic repercussion, complications and opportunity in the treatment.

Case Report: Male 33 years of age who began with sudden dyspnea, chest pain of moderate intensity, sweating and syncope. Read More

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November 2018

Linkages between epithelial microbiota and host transcriptome in the ileum during high grain challenges: implications for gut homeostasis in goats.

J Agric Food Chem 2018 Dec 6. Epub 2018 Dec 6.

A high-grain diet (HG) can result in ruminal subacute acidosis, which is detrimental to gut health and can lead to decreased productivity. This study investigated the ileal epithelial microbiota and its relationship with host epithelial function in goats fed an HG diet (concentrate: hay, 90: 10) and a Control diet (concentrate: hay, 55: 45) aiming to elucidate the mechanisms involved in ileal adaptation to subacute acidosis. The HG challenge increased ileal volatile fatty acid concentration (P = 0. Read More

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December 2018
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Caring for the older person with cognitive impairment in hospital: qualitative analysis of nursing personnel reflections on fall events.

J Clin Nurs 2018 Dec 5. Epub 2018 Dec 5.

School of Nursing & Midwifery and Menzies Health Institute Queensland, Griffith University and Gold Coast Hospital and Health Service, 2.05c, G01, Gold Coast Campus, Griffith University, Southport, Queensland.

Aims And Objectives: To explore nurse and nursing assistant reflections on the care of older patients with cognitive impairment who have experienced a fall.

Background: While there are evidence-based clinical guidelines for the prevention and management of falls and for the care of older people with cognitive impairment, the falls rates for older people with cognitive impairment is three times as high as those without.

Design: Critical incident technique. Read More

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December 2018
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White matter microstructure varies with post-traumatic stress severity following medical trauma.

Brain Imaging Behav 2018 Dec 5. Epub 2018 Dec 5.

Department of Psychology, University of Alabama at Birmingham, CIRC 235H, 1720 2nd Avenue South, Birmingham, AL, 35294, USA.

The prefrontal cortex, amygdala, hippocampus, and hypothalamus are important components of the neural network that mediates the healthy learning, expression, and regulation of emotion. These brain regions are connected by white matter pathways that include the cingulum bundle, uncinate fasciculus, and fornix/stria terminalis. Individuals with trauma and stress-related disorders show dysfunction of the cognitive-affective processes supported by the brain regions these white matter tracts connect. Read More

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December 2018
1 Read

Delayed presentation of complete arterial transection treated with interposition graft: A case report.

Trauma Case Rep 2018 Dec 24;18:24-27. Epub 2018 Nov 24.

Department of Surgery, University of Colorado, Denver, United States of America.

Introduction: Traumatic arterial injuries have a high degree of morbidity if left untreated. Frequently, arterial injuries are found soon after injury due to either subjective complaints or objective findings. Opportunity for delayed repair of vascular injury is a rare event as irreversible ischemia occurs at such early time points. Read More

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December 2018

Intracranial dural arteriovenous fistula mistaken as cervical transverse myelitis.

Pract Neurol 2018 Dec 5. Epub 2018 Dec 5.

Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK

We describe a man with an intracranial dural arteriovenous fistula that presented as a subacute longitudinally extensive cervical myelopathy. The uncommon location of the fistula and the absence of specific radiological signs resulted in initial misdiagnosis as longitudinally extensive transverse myelitis. Neurologists should have a high index of suspicion for dural arteriovenous fistula in older men, especially those with subacute or chronic symptoms, acellular cerebrospinal fluid and, particularly, if there is neurological deterioration soon after corticosteroid treatment. Read More

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December 2018

Assessment of chiropractic care on strength, balance, and endurance in active-duty U.S. military personnel with low back pain: a protocol for a randomized controlled trial.

Trials 2018 Dec 5;19(1):671. Epub 2018 Dec 5.

The Spine Institute for Quality, 102 2nd Street, Davenport, IA, 52801,, USA.

Background: Low back pain (LBP) is a common cause of disability among U.S. military personnel. Read More

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December 2018

Intravenous Lidocaine Administered as Twice Daily Bolus and Continuous Infusion for Intractable Cancer Pain and Wound Care Pain.

J Palliat Med 2018 Dec 1. Epub 2018 Dec 1.

3 Spectrum Health Medical Group , Palliative Care Medicine, Grand Rapids, Michigan.

Introduction: Intravenous lidocaine is an option for intractable pain caused by advancing cancer and wound care. We report a case of intractable cancer pain and wound care pain managed with concurrent use of lidocaine administered as a twice daily intravenous bolus in addition to continuous intravenous infusion.

Case Description: A 31-year-old male with rapidly progressing locally advanced squamous cell cancer affecting the gluteal area developed extensive painful and purulent ulcerating wounds affecting the coccyx, superior gluteal cleft, and buttocks. Read More

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December 2018
4 Reads

Traumatic spinal cord injury in West Virginia: Disparities by insurance and discharge disposition from an acute care hospital.

J Spinal Cord Med 2018 Dec 3:1-5. Epub 2018 Dec 3.

c WVU Medicine, One Medical Center Drive , Morgantown , West Virginia , USA.

Context: Medicaid has been linked to worse outcomes in a variety of diagnoses such as lung cancer, uterine cancer, and cardiac valve procedures. It has furthermore been linked to the reduced health-related quality of life outcomes after traumatic injuries when compared to other insurance groups. In spinal cord injury (SCI), the care provided in the subacute setting may vary based upon payor status, which may have implications on outcomes and cost of care. Read More

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December 2018
1 Read

Robot-assisted gait training effectively improved lateropulsion in subacute stroke patients: a single-blinded randomized controlled trial.

Eur J Phys Rehabil Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Rehabilitation Medicine, Wonkwang University School of Medicine, Iksan, Republic of Korea -

Background: Some stroke patients are known to use nonparetic extremities to push toward the paretic side, a movement known as lateropulsion. Lateropulsion impairs postural balance and interferes with rehabilitation.

Aim: The aim of the present study was to investigate the effect of robot-assisted gait training (RAGT) on recovery from lateropulsion compared with conventional physical therapy (CPT). Read More

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December 2018

Personalized Lu-octreotate peptide receptor radionuclide therapy of neuroendocrine tumours: initial results from the P-PRRT trial.

Eur J Nucl Med Mol Imaging 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiology and Nuclear Medicine, Université Laval, Quebec City, Canada.

Purpose: Peptide receptor radionuclide therapy (PRRT) is mostly administered using a fixed injected activity (IA) per cycle. This empiric regime results in highly variable absorbed doses to the critical organs and undertreatment of the majority of patients. We conceived a personalized PRRT protocol in which the IA is adjusted to deliver a prescribed absorbed dose to the kidney, with the aim to safely increase tumour irradiation. Read More

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November 2018

The concept of rapid rescue radiosurgery in the acute management of critically located brain metastases: A retrospective short-term outcome analysis.

Surg Neurol Int 2018 30;9:218. Epub 2018 Oct 30.

Department of Neurosurgery, Karolinska Institute, Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden.

Background: Adaptive hypofractionated gamma knife radiosurgery has been used to treat brain metastases in the eloquent regions while limiting the risk of adverse radiation effect (ARE). Ablative responses might be achieved within days to weeks with the goal to preserve the neurological function. The application of this treatment modality in selected acute/subacute settings has been termed Rapid Rescue Radiosurgery (RRR) in our department. Read More

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October 2018
1 Read

Immune-mediated neurological manifestations of dengue virus- a study of clinico-investigational variability, predictors of neuraxial involvement, and outcome with the role of immunomodulation.

Neurol India 2018 Nov-Dec;66(6):1634-1643

Department of Neurology, Government Medical College Kota, Rajasthan, India.

Introduction: Our aim was to study dengue-related immune-mediated neurological complications (IMNC) during the recent epidemic.

Materials And Methods: This was a cross-sectional observational study of 79 IMNC cases from 1627 laboratory confirmed dengue cases from January 2015 to January 2016 and their follow-up for 3 months. According to the World Health Organization, cases were categorized into those having dengue fever (DF), and those having a severe syndrome that includes dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Read More

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December 2018
4 Reads

Pre- and postoperative predictors of phantom limb pain.

Neurosci Lett 2018 Nov 29. Epub 2018 Nov 29.

Department of Clinical and Cognitive Neuroscience, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany. Electronic address:

Phantom limb (PLP) as well as residual limb pain (RLP) are still a very significant problem after amputation and their causes are only partially known. Here we tested whether the predisposition for the frequency, duration and intensity of PLP and RLP is shared with other prior chronic pains and/or the presence of postamputation subacute pain. A week preoperatively we collected data using validated questionnaires, a pain diary and interviews on past chronic pain conditions, acute pain, depression, anxiety, pain interference, life control, social support and affective distress and pain ratings one day before the amputation in 52 patients scheduled for limb amputation. Read More

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November 2018

Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury.

Stem Cell Reports 2018 Dec 29;11(6):1416-1432. Epub 2018 Nov 29.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Electron Microscope Laboratory, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address:

Treatment involving regenerative medicine for chronic spinal cord injury (SCI) is difficult due to phase-dependent changes in the intraspinal environment. We previously reported that treatment with a gamma-secretase inhibitor (GSI), which inhibits Notch signaling, promotes the differentiation into mature neurons in human induced pluripotent stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC) transplantation for subacute SCI. Here, we evaluated the efficacy of GSI-treated hiPSC-NS/PC transplantation in treating chronic SCI, which resulted in significantly enhanced axonal regrowth, remyelination, inhibitory synapse formation with the host neural circuitry, and reticulo spinal tract fiber formation. Read More

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December 2018

Virtual Reality and Noninvasive Brain Stimulation in Stroke: How Effective Is Their Combination for Upper Limb Motor Improvement?-A Meta-Analysis.

PM R 2018 Nov;10(11):1261-1270

School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada(†).

Background: Efforts to augment post-stroke upper limb (UL) motor improvement include the use of newer interventions such as noninvasive brain stimulation (NIBS) and task practice in virtual reality environments (VEs). Despite increasing interest in using a combination of these 2 interventions, the effectiveness of this combination to enhance UL motor improvement outcomes has not been examined.

Objective: To evaluate the effectiveness of a combination of NIBS and task practice in a VE to augment post-stroke UL motor improvement. Read More

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November 2018

Subacute Venous Infarct Mimicking Cerebral Metastasis in 18F-FDG PET/CT.

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

From the Departments of Nuclear Medicine and.

A 68-year-old woman with colon carcinoma was referred to F-FDG PET/CT imaging for staging. In addition to primary tumor involvement, PET/CT demonstrated focal FDG uptake in the right temporal lobe suggestive of primary brain tumor or metastasis. To delineate the lesion, a brain MRI scan showed sigmoid sinus thrombosis and vasogenic edema in the right temporal lobe. Read More

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December 2018
4 Reads

THE INFLUENCE OF SODIUM SALTS OF CARBOXYMETHYLATES OF OXYETHYLATED ISONONYLPHENOLS ON THE NEUTRALIZING FUNCTION OF THE LIVER IN A SUBACUTE TOXICOLOGICAL EXPERIMENT.

Georgian Med News 2018 Oct(283):140-144

Kharkiv National Medical University, Ukraine.

The study was conducted as a part of research work "Biochemical mechanisms of the development of dismetabolic processes under the influence of chemical environmental factors". The purpose of the present work was to study the effects produced by sodium salts of carboxymethylates of oxyethylated isononylphenols on the state of the microsomal monooxygenase system of hepatocyte detoxification and on the conjugation reaction in conditions of a subacute experiment and to reveal a potential danger for homoitherms and human beings. The object of the study were the white rats of WAG population. Read More

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October 2018
1 Read

CHANGES OF PROTEINURIA AND ACID-REGULATING KIDNEY FUNCTION IN MATURE RATS WITH SLOW AND RAPID ACETYLATION TYPE UNDER CONDITIONS OF SUBACUTE CADMIUM-NITRATE INTOXICATION.

Georgian Med News 2018 Oct(283):133-137

Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine.

The experiments conducted on non-linear mature laboratory albino rats determined that under conditions of subacute cadmium-nitrate intoxication the indices of proteinuria and acid-regulating renal function depend on acetylation phenotype. Unlike rapid acetylators considerable increase of protein concentration in urine (192,8%, р<0,05) and standardized by glomerular filtration protein excretion (141,7%, р<0,05) are indicative of higher susceptibility of rats with slow acetylation type to nephrotoxic action of cadmium chloride and sodium nitrate. Lack of protein loss with urine and adaptive-compensative character of acid-regulating renal function changes directed to elimination of hydrogen ions excess from the body give evidence concerning less intensive damage of the nephron tubular portion in rats with rapid acetylation type, and at the same time do not exclude development of nephropathy. Read More

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October 2018
1 Read

Experiences with a temporary synthetic skin substitute after decompressive craniectomy: a retrospective two-center analysis.

Acta Neurochir (Wien) 2018 Dec 4. Epub 2018 Dec 4.

Department of Neurosurgery, Trauma Center Murnau, Professor-Küntscher Straße 8, 82418, Murnau, Germany.

Background: Decompressive craniectomy is a commonly performed procedure. It reduces intracranial pressure, improves survival, and thus might have a positive impact on several neurosurgical diseases and emergencies. Sometimes primary skin closure is not possible due to cerebral herniation or extensive skin defects. Read More

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December 2018
1 Read

Productive Propagation of Rift Valley Fever Phlebovirus Vaccine Strain MP-12 in Rousettus aegyptiacus Fruit Bats.

Viruses 2018 Nov 30;10(12). Epub 2018 Nov 30.

Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.

Rift Valley fever phlebovirus (RVFV), the causative agent of an emerging zoonotic disease in Africa and Arabia, can infect a variety of species, predominantly ruminants, camelids, and humans. While clinical symptoms are mostly absent in adult ruminants and camelids, RVFV infection may lead to a serious, sometimes fatal disease in humans. Virus transmissions between individuals and between species mainly occur through mosquito bites, but direct or even indirect contact with infectious materials may also result in infection. Read More

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November 2018
1 Read

A case of steroid-resistance Hashimoto's encephalopathy presenting with sensorimotor polyneuropathy.

Turk J Pediatr 2018 ;60(3):310-314

Division of Pediatric Neurology, Department of Pediatrics, Necmettin Erbakan University, Meram Faculty of Medicine, Konya, Turkey.

Emeksiz S, Kutlu NO, Alaçakır N, Çaksen H. A case of steroid-resistance Hashimoto's encephalopathy presenting with sensorimotor polyneuropathy. Turk J Pediatr 2018; 60: 310-314. Read More

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January 2018
4 Reads

A Case of Thyrotoxicosis due to Simultaneous Occurrence of Subacute Thyroiditis and Graves' Disease.

Case Rep Endocrinol 2018 30;2018:3210317. Epub 2018 Oct 30.

Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.

Subacute thyroiditis is an inflammatory disorder of the thyroid. Graves' disease is an autoimmune thyroid disease in which thyroid hormones are overproduced. Here we present a rare case of thyrotoxicosis due to the simultaneous occurrence of both diseases. Read More

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October 2018
2 Reads

STORE-gastrointestinal functions and gastrointestinal hormones in patients with liver failure.

Medicine (Baltimore) 2018 Nov;97(48):e13167

Department of Preventive Medicine, Medical College, Henan University of Science and Technology.

This study aims to investigate the gastrointestinal functions of patients with liver failure (LF) based on gastrointestinal dysfunction (GD) scores and serum gastrointestinal hormone levels.The GD in LF patients was scored using the gastrointestinal dysfunction scoring criteria. Serum gastrin (GAS), cholecystokinin (CCK), and motilin (MTL) levels were determined in LF patients. Read More

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November 2018
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[A patient with a red and swollen leg].

Ned Tijdschr Geneeskd 2018 11 19;162. Epub 2018 Nov 19.

Medisch Centrum Leeuwarden, afd. Spoedeisende Hulp.

A 66-year-old patient was seen at the emergency department with a skin infection of the left leg, probably erysipelas, which worsened despite the use of antibiotics. The symptoms had started 5 days earlier. The patient was respiratory and haemodynamically stable, he was not clinically ill and had relatively little pain. Read More

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November 2018

POEMS syndrome: clinical update.

J Neurol 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurology, Royal Free Hospital, Pond Street, London, NW3 2QG, UK.

POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes) is a rare paraneoplastic syndrome, caused by a plasma cell proliferative disorder, which is most commonly lambda restricted. The neurological hallmark, which forms one of the mandatory criteria for diagnosis, is a subacute onset demyelinating neuropathy, which can be rapidly disabling and painful. A number of multi-system features are also characteristic of this disorder, and certainly not restricted to those included in its acronym, which though limited, remains a useful and memorable name, helping distinguish POEMS syndrome from other paraproteinaemic neuropathies. Read More

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November 2018
3 Reads