37,079 results match your criteria Struma Ovarii


Socioeconomic disparities in a population of patients undergoing total thyroidectomy for benign disease.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California.

Background: This study examines the effect of insurance status (as a measure of socioeconomic status) on patient with benign thyroid disease.

Methods: A retrospective review was performed among 60 patients undergoing total thyroidectomy for benign thyroid disease. Univariate and multivariable analyses examined the relationship between insurance status and thyroid volume (sum of the left and right lobe volumes). Read More

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December 2018

Expression of Metallothionein I/II and Ki-67 Antigen in Graves' Disease.

Anticancer Res 2018 Dec;38(12):6847-6853

Department of Histology and Embryology, Medical University of Wroclaw, Wroclaw, Poland.

Background/aim: The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid.

Patients And Methods: MT-I/II and Ki-67 antigen expression was studied using immunohistochemistry in 72 GD and 24 NG patients.

Results: MT-I/II expression was noted in the cytoplasm and nuclei of thyrocytes of GD and NG patients. Read More

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December 2018

Recurrent goiters: risk factors, patient quality of life, and efficacy of radioiodine therapy.

Pol Arch Intern Med 2018 Dec 5. Epub 2018 Dec 5.

INTRODUCTION Goiter recurrence occurs in a substantial number of patients after thyroid resection. OBJECTIVES We aimed to investigate the prevalence and risk factors of recurrent goiters, influence of goiter recurrence on patient quality of life (QoL) and the efficacy of therapy with radioactive iodine (RAI). PATIENTS AND METHODS This was a case-control study. Read More

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December 2018

B cells in Graves' Orbitopathy: more than just a source of antibodies?

Eye (Lond) 2018 Dec 4. Epub 2018 Dec 4.

Graves' Orbitopathy Center, Endocrinology, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico and University of Milan, Milan, Italy.

B cells have multiple actions on different phases of an immune reaction, mainly resulting in B and T cell-interaction (help), production of cytokines, regulation of dendritic cells and downregulation of regulatory B cells. The effectiveness of B cell depletion therapy is probably due to blockade of the antigen-presenting function of B cells, occurring very early in the setting of autoimmune reactions. B cells undergo a maturation process from stem cells during which the CD 20 antigen, which is the target of rituximab (RTX), is expressed from the stage of pre-B cells to mature and memory B cells, but not on plasma cells. Read More

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December 2018
1 Read

Le score échographique EU-TIRADS permet de prédire le risque de carcinome.

Authors:
Gilles Russ

Rev Prat 2017 Jun;67(6):663-668

Centre de pathologie et d'imagerie, Paris, France, unité thyroïde et tumeurs endocrines (Pr Leenhardt), groupe hospitalier La Pitié-Salpêtrière, UPMC université Paris-VI, Paris, France.

Management of thyroid nodules. Thyroid nodules are frequent and most of them are benign incidentalomas. Physical examination will search for risk factors of thyroid cancer and should evaluate the presence of local or cosmetic symptoms. Read More

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Management of fetal goiters : 6-year retrospective observational study in three prenatal diagnosis and treatment centers of the Pays de Loire perinatal network.

J Matern Fetal Neonatal Med 2018 Dec 4:1-191. Epub 2018 Dec 4.

a Department of Gynecology and Obstetrics , CIC Hôpital Mère-Enfant , Nantes , France.

Introduction: The incidence of fetal goiters is reported to be around 1 per 40 000 births. The risk of complications is first of all obstetric, directly related to goiter size, but it may also affect longer term fetal and child development, depending on whether the goiter is due to hypo- or hyperthyroidism. Management is multidisciplinary, but not yet consensual and not always optimal by either endocrinologists or obstetricians. Read More

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December 2018
3 Reads

The role of matrix metalloproteinase-9 as a prognostic biomarker in papillary thyroid cancer.

BMC Cancer 2018 Dec 3;18(1):1199. Epub 2018 Dec 3.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran.

Background: The aim of the present study was to investigate the association between matrix metalloproteinase-9 (MMP-9) expression with BRAF V600E mutation and clinicopathological features, in Iranian papillary thyroid cancer (PTC) patients.

Methods: In total, 90 participants including 60 PTC patients (15 males and 45 females) and 30 individuals with benign multinodular goiter (MNG) (5 males and 25 females) which were confirmed by surgical pathology, were investigated. MMP-9 was evaluated at both mRNA and protein levels, using SYBR-Green Real-Time PCR and enzyme-linked immune sorbent assay (ELISA), respectively. Read More

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December 2018
2 Reads

Imprint cytology of strumal carcinoid of the ovary: A case report with immunocytochemical analysis.

Diagn Cytopathol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pathology and Laboratory Medicine, Kansai Medical University, Hirakata, Japan.

Strumal carcinoid is a rare ovarian tumor defined as carcinoid associated with struma ovarii. We report here the second cytological case of strumal carcinoid and performed immunocytochemical analysis for the first time. A 68-year-old Japanese female was found to have a solid tumor with small cystic components in the left ovary, and bilateral salpingo-oophorectomy was performed. Read More

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November 2018

Serum-based metabolic alterations in patients with papillary thyroid carcinoma unveiled by non-targeted 1H-NMR metabolomics approach.

Iran J Basic Med Sci 2018 Nov;21(11):1140-1147

Department of Basic Sciences, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: As the most prevalent endocrine system malignancy, papillary thyroid carcinoma had a very fast rising incidence in recent years for unknown reasons besides the fact that the current methods in thyroid cancer diagnosis still hold some limitations. Therefore, the aim of this study was to improve the potential molecular markers for diagnosis of benign and malignant thyroid nodules to prevent unnecessary surgeries for benign tumors.

Materials And Methods: In this study, 1H-NMR metabolomics platform was used to seek the discriminating serum metabolites in malignant papillary thyroid carcinoma (PTC) compared to benign multinodular goiter (MNG) and healthy subjects and also to better understand the disease mechanisms using bioinformatics analysis. Read More

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November 2018
1 Read

The Smallest Reported Malignant Struma Ovarii: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):693-698. Epub 2018 Oct 31.

Department of Gynecology and Obstetrics, Tagawa Municipal Hospital, Fukuoka, Japan.

Introduction: Malignant struma ovarii is a rare neoplasm. It is usually asymptomatic and not commonly diagnosed preoperatively. In addition, there is currently no established diagnostic and therapeutic approach for malignant struma ovarii. Read More

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October 2018
1 Read

Intraoperative carbon nanoparticles mapping in secondary total thyroidectomy for recurrent thyroid nodules: Results of a 8-criterion case-match study (case control study).

Int J Surg 2018 Nov 23;60:210-215. Epub 2018 Nov 23.

Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address:

Background: The extent of total thyroidectomy in the management of multinodular goiter remains unclear. Compared to primary thyroidectomy, secondary total thyroidectomy is more difficult to perform and carries a significantly higher risk of postoperative complications such as recurrent laryngeal nerve (RLN) palsy or hypoparathyroidism. In this study, we aimed to evaluate the efficacy and safety of intraoperative carbon nanoparticle (CN) mapping in patients undergoing secondary total thyroidectomy. Read More

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November 2018
3 Reads

Giant adenomatous thyroid nodule compressing the trachea.

J Gen Fam Med 2018 Nov 29;19(6):219-220. Epub 2018 Aug 29.

Department of General Internal Medicine Mitoyo General Hospital Kanonji Japan.

This paper details the clinical history and management of a 20-year-old male patient who presented with a 2-year history of a neck swelling which was gradually enlarging during the last 3 months. The tumor was histologically diagnosed as an adenomatous nodule of the thyroid gland. Read More

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November 2018
3 Reads

[Thyroid medicine for ENT physicians].

HNO 2018 Dec;66(12):937-950

Klinik für Hals‑, Nasen‑, Ohrenheilkunde und plastische Operationen, Asklepios Klinik St. Georg, Lohmühlenstraße 5, 20099, Hamburg, Deutschland.

Diseases of the thyroid gland are frequent incidental findings during ultrasound examination of the neck. They affect nearly one third of the normal population. Treatment is not always indicated; however, laboratory diagnostic measures must be initiated to specify the disease. Read More

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December 2018
3 Reads

[Tc]-99m thyroid scintigraphy in more than 210 cases of permanent congenital hypothyroidism and its correlation with the 1st diagnostic serum thyrotropin.

Authors:
Majid Aminzadeh

Endokrynol Pol 2018 Nov 19. Epub 2018 Nov 19.

Objective: A big part of cases of congenital hypothyroidism(CH) in Iran are transient. This study designed to investigate etiology of permanent CH(PCH) by thyroid scintigraphy(TS) and its relationship with the first diagnostic thyrotropin(TSH).

Methods: During twelve years (2005-2017) of CH screening in southwest Iran, all infants referred with the diagnosis of CH were followed until the 3rd birthday that they were reevaluated for serum T4,TSH after 3-4 weeks treatment discontinuation. Read More

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November 2018
7 Reads

An evaluation score of the difficulty of thyroidectomy considering operating time and preservation of recurrent laryngeal nerve.

Updates Surg 2018 Nov 15. Epub 2018 Nov 15.

Department of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro 129, 90127, Palermo, Italy.

The purpose of this study was to edit a renovated thyroidectomy difficulty scale (rTDS) in order to identify underlying thyroid diseases with a longer operative time and higher technical difficulty, also considering preservation of recurrent laryngeal nerve. We developed a renovated scale with a maximum score of 20 points by creating a form in which five variables were considered: vascularity, friability, mobility/fibrosis, gland size and difficulty in preservation of the recurrent laryngeal nerve. Two surgeons separately evaluated each of these. Read More

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November 2018
4 Reads

Increased Expression of GARP in Papillary Thyroid Carcinoma.

Endocr Pathol 2018 Nov 16. Epub 2018 Nov 16.

Department of Anatomy, College of Basic Medical Sciences of Jinzhou Medical University, Jinzhou, 121001, Liaoning, China.

Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. Read More

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November 2018
4 Reads

Bilateral Displacement of the Common Carotid Arteries by a Large Goiter.

Cureus 2018 Sep 13;10(9):e3298. Epub 2018 Sep 13.

Neurosurgery, Seattle Science Foundation, Seattle, USA.

Large goiters are less common in the developing world due to the use of iodized salt. However, these are seen occasionally. Herein, we report a case of very large goiter identified in a cadaver. Read More

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September 2018

[Analysis of surveillance on iodine deficiency disorders in the interim of readjustment of salt iodine in Sichuan Province].

Zhonghua Yu Fang Yi Xue Za Zhi 2018 Nov;52(11):1190-1192

Institute for Endemic Diseases Control and Prevention, Sichuan Center for Disease Control and Prevention, Chengdu 610041, China.

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November 2018
1 Read

Unilateral benign multinodular versus solitary goiter: Long-term contralateral reoperation rates after lobectomy.

Surgery 2018 Nov 8. Epub 2018 Nov 8.

Department of Visceral and Endocrine Surgery, CHU Poitiers, Poitiers, France. Electronic address:

Background: Few long-term studies define the appropriate extent of surgery and recurrence rates for unilateral multinodular goiter. We compared the rate and time to reoperation in patients with multinodular goiter who underwent lobectomy to that of patients with benign solitary nodule.

Methods: Retrospective study of a prospective database of all patients who underwent lobectomy for multinodular goiter or solitary nodule from 1991 to 2017. Read More

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November 2018
4 Reads

Hypothyroidism induced by phenytoin and gabapentin: A Case Report.

Medicine (Baltimore) 2018 Oct;97(43):e12938

Department of Neurology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Rationale: Antiepileptic drugs (AEDs) are one of the causative drugs of drug-induced hypothyroidism. In most cases, AED-induced hypothyroidism is subclinical and indicated only by abnormalities of free thyroxine (T4) and/or thyroid-stimulating hormone (TSH) levels. Severe symptomatic hypothyroidism following AEDs is rarely reported in the literature. Read More

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October 2018
12 Reads

Nonimmune hydrops fetalis: identifying the underlying genetic etiology.

Genet Med 2018 Nov 9. Epub 2018 Nov 9.

Department of Obstetrics, Gynecology, & Reproductive Sciences, University of California, San Francisco, CA, USA.

Purpose: Numerous etiologies may lead to nonimmune hydrops fetalis (NIHF), and the underlying cause often remains unclear. We aimed to determine the proportion of NIHF cases in which the etiology was clearly determined in a large, contemporary, and diverse cohort, as well as to describe the etiologies with a focus on genetic causes.

Methods: Retrospective review of NIHF cases between 2015 and 2017 from the five University of California Fetal-Maternal Consortium sites. Read More

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November 2018
1 Read

A rare case of primary thyroid amyloidosis.

Int J Surg Case Rep 2018 Oct 25;53:179-181. Epub 2018 Oct 25.

Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Catania, Italy.

Introduction: Amyloid goiter is due to the deposition of amyloid in the thyroid, resulting with enlargement of the gland and compressive symptoms.

Case: We herein present a case of a 45-year-old male patient who complained of a big swelling in the neck. Ultrasound showed an enlarged thyroid gland with mediastinal involvement. Read More

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October 2018
3 Reads

Autoimmune thyroid diseases are more common in patients with prolactinomas: a retrospective case-control study in an Italian cohort.

J Endocrinol Invest 2018 Nov 8. Epub 2018 Nov 8.

Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.

Background: Prolactin may exert immunological effects. Over the years, a higher prevalence of autoimmune thyroid diseases (ATD) has been reported in patients with prolactinomas (PRLs) in areas with sufficient iodine intake.

Purpose: The aim of our study was to evaluate the prevalence of ATD [Graves' disease (GD) and chronic autoimmune thyroiditis (AIT)] in a retrospective cohort of Italian patients with PRLs compared to a sex-matched control group, represented by subjects with non-functioning pituitary adenoma (NFPA) or empty sella (ES). Read More

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November 2018
2 Reads

Validation of a novel patient-reported outcome measure for parathyroid and thyroid disease (PROMPT).

Surgery 2018 Nov 3. Epub 2018 Nov 3.

Cleveland Clinic Foundation.

Background: Patient-reported outcome measures are being used increasingly to assess disease severity and response to surgery. The purpose of this study was to create and validate a patient-reported outcome measure for symptoms of thyroid enlargement and hyperparathyroidism, 2 conditions where the presence of preoperative symptoms and response to surgery is often questioned.

Methods: A questionnaire reviewing common symptoms was developed from a literature review and expert opinion. Read More

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November 2018
4 Reads

Complete Remission After Single Radioiodine Therapy in Malignant Struma Ovarii With Bone and Lymph Node Metastases.

Clin Nucl Med 2018 Nov 3. Epub 2018 Nov 3.

Institute of Pathology, Essen University Hospital, Essen, Germany.

A 67-year-old woman presented with malignant struma ovarii after radical bilateral salpingo-oophorectomy. The surgery revealed a 4.4 cm papillary thyroid carcinoma (follicular variant) within a right-sided ovarian teratoma. Read More

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November 2018
5 Reads

Serum levels of intact parathyroid hormone on the first day after total thyroidectomy as predictor of permanent hypoparathyroidism.

Endocrinol Diabetes Nutr 2018 Nov 1. Epub 2018 Nov 1.

Servicio de Cirugía General y Aparato Digestivo, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.

Background: Permanent hypoparathyroidism is the most common long-term complication after total thyroidectomy, causing significant morbidity and requiring long-term replacement therapy. Our study objective was to assess whether intact parathyroid hormone (iPTH) levels on the first day after total thyroidectomy are a good predictor of permanent hypoparathyroidism.

Patients And Methods: A retrospective observational study of all patients undergoing total thyroidectomy between January 2009 and December 2014. Read More

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November 2018
1 Read

Can Thyroid Ultrasonography Predict Substernal Extension or Tracheal Compression in Goiters?

Can Assoc Radiol J 2018 Nov;69(4):422-429

Department of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:

Purpose: To determine whether an ultrasonography (US)-defined thyroid volume can accurately predict substernal extension or tracheal narrowing.

Methods: After research ethics approval, we identified patients with thyroid nodules investigated with both US and computed tomography (CT). Reviewers assigned scores for both substernal extension and tracheal compression on CT using pre-established classification systems. Read More

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November 2018
5 Reads

High-dose preoperative cholecalciferol to prevent post-thyroidectomy hypocalcaemia: a randomized, double-blind placebo-controlled trial.

Clin Endocrinol (Oxf) 2018 Nov 1. Epub 2018 Nov 1.

School of Medicine and Public Health, University of Newcastle, Australia.

Objective: Post-thyroidectomy hypocalcaemia is a significant cause of morbidity and prolonged hospitalization, usually due to transient parathyroid gland damage, treated with calcium and vitamin D supplementation. We present a randomized, double-blind placebo-controlled trial of preoperative loading with high-dose cholecalciferol (300,000 units) to reduce post-thyroidectomy hypocalcaemia.

Patients And Measurements: Patients (n=160) presenting for thyroidectomy at tertiary hospitals were randomized 1:1 to cholecalciferol (300,000 IU) or placebo 7 days prior to thyroidectomy. Read More

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November 2018
2 Reads

Association of benign thyroid diseases with thyroid cancer risk: a meta-analysis of prospective observational studies.

J Endocrinol Invest 2018 Nov 1. Epub 2018 Nov 1.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, China.

Purpose: Evidence showed that benign thyroid disease was one of the risk factors for thyroid cancer. However, the results of some studies were inconsistent and were previously meta-analyses of case-control studies. Therefore, we performed a meta-analysis of prospective studies to investigate the relationship between benign thyroid diseases and thyroid cancer risk. Read More

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November 2018
4 Reads

Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families.

Thyroid 2018 Oct 30. Epub 2018 Oct 30.

University of Miami School of Medicine, 12235, Medicine , 1120 NW 14th St , Suite 310F , Miami, Florida, United States , 33136-1015 ;

Dyshormonogenic congenital hypothyroidism (CH) generally results from biallelic defects in thyroid hormone synthesis genes. Whole exome sequencing (WES) allows easier identification of multiple gene defects. We present 2 Sudanese families with CH resulting from oligogenic defects identified by WES. Read More

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October 2018
1 Read

Thyroid Swelling: A Common Phenomenon in Art?

Eur Thyroid J 2018 Oct 3;7(5):272-278. Epub 2018 May 3.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.

Representations of thyroid swelling, intended as an enlarged anterior neck region, in the artworks of various periods are sporadically reported in the scientific literature, and different intents may be hypothesized. A comprehensive review of the international literature was performed on PubMed, Embase, and ResearchGate with the aim to analyze the modalities of representation of thyroid swelling through the ages by different artistic movements. Thyroid swelling is frequently represented in the artworks of many stylistic periods and seems to be a known condition even by the earliest cultures. Read More

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October 2018
2 Reads

Feasibility of Endoscopic Thyroidectomy via Axilla and Breast Approaches for Larger Goiters: Widening the Horizons.

J Thyroid Res 2018 2;2018:4057542. Epub 2018 Oct 2.

Department of Endocrine Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow 226014, India.

Scarless (in the neck) endoscopic thyroidectomy (SET) has evolved into a cosmetically preferred alternative to conventional thyroidectomy (ConT). Recently many of our patients are demanding SET; however their goitres are larger than the recommended size of 4-6 cm. Our aim was to compare the outcomes of ET for small (<6 cm) vs large (≥6 cm) goitres and determine its feasibility in such cases. Read More

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October 2018
2 Reads

Effect of Reduction in Iodine Content of Edible Salt on the Iodine Status of the Chinese Population.

Biomed Environ Sci 2018 Sep;31(9):645-653

Institute for Iodine Deficiency Disorders Control, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang, China.

Objective: The aim of this study was to evaluate the impact of the revised Chinese National Standard GB26878-2011 'Iodine Content in Edible Salt' on the iodine status among the Chinese population.

Methods: In 2011 and 2014, the probability proportionate to size sampling (PPS) was used in each Chinese province to obtain the representative data. In each sampling unit, school children aged 8-10 years and pregnant women were selected. Read More

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September 2018
2 Reads

A case report of a concomitant total thyroidectomy and carotid body tumor resection in a 43 year old female.

Int J Surg Case Rep 2018 Oct 17;53:17-20. Epub 2018 Oct 17.

Department of Surgery, Section of Vascular Surgery and Endovascular Therapy, Instituto Nacional de Ciencias Médicas y Nutricion Salvador Zubirán, Mexico City, Mexico. Electronic address:

Introduction: Carotid body tumors (CBT) are rare neoplasms with relatively; due to their malignant potential, the indicated treatment is surgical resection. There have been described some associations of carotid body tumors with other neoplasms, however, the concomitant presentation of CBT with multinodular goiter is rarely encountered.

Presentation Of Case: We herein present the case of a 43-year old woman with the aforementioned association. Read More

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October 2018
5 Reads

Sudden, Unexpected Death Due to Pseudo-Meigs Syndrome: A Case Report and Review of the Literature.

Am J Forensic Med Pathol 2018 Oct 23. Epub 2018 Oct 23.

Department of Clinical Pathology, ASL 1 Imperiese - Sanremo Hospital, Sanremo, Italy.

Meigs syndrome is the triad of ascites, hydrothorax, and benign ovarian tumor (mostly fibroids). It is a diagnosis of exclusion, and the characteristic symptoms disappear after resection of the tumor. Instead, in Pseudo-Meigs syndrome, the triad includes a nonfibroma ovarian tumor. Read More

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October 2018
1 Read

Comparison of Iodine Concentrations in Kitchen Salt and Urine with the Thyroid Volume of Schoolchildren from Ribeirão Preto, São Paulo, Brazil: Warning of Worsening After 10 Years of Study.

Thyroid 2018 Nov 27. Epub 2018 Nov 27.

3 Department of Internal Medicine, School of Medicine of Ribeirão Preto USP, Ribeirão Preto, Brazil.

Background: In 2007 and 2015, two studies were conducted in Ribeirão Preto, São Paulo, Brazil, on schoolchildren of both sexes attending schools of three different socioeconomic levels (school 1: low; school 2: middle; school 3: high).

Methods: Iodine concentrations were measured in samples of kitchen salt from the home provided by the schoolchildren and in urine samples, and these levels were compared to the thyroid volume by clinical assessment.

Results: In 2007, a marked discrepancy in iodine concentrations was found in salt samples in 300 schoolchildren of both sexes (age range 8-10 years). Read More

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November 2018
2 Reads

De novo coronary artery disease in graves' disease. coincidence?

J Community Hosp Intern Med Perspect 2018 15;8(5):292-295. Epub 2018 Oct 15.

Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

Hyperthyroidism is associated with increased risk of cardiovascular conditions. We report a case of a 50-year-old woman with no prior cardiac history who presented to the emergency department with shortness of breath, chest pain, lower extremity swelling, and generalized fatigue. She was found to have Graves' Disease (GD) and extensive coronary artery disease (CAD), suggesting the possibility of increased risk of de novo CAD in patients with GD in the absence of other risk factors. Read More

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October 2018
2 Reads

Polymorphisms of FAM167A-BLK Region Confer Risk of Autoimmune Thyroid Disease.

DNA Cell Biol 2018 Nov 23;37(11):932-940. Epub 2018 Oct 23.

1 Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital , Shanghai, China .

The present study was to explore whether the polymorphisms of FAM167 A-BLK region are associated with the susceptibility to autoimmune thyroid disease (AITD). The second sequencing technology was undertaken for seven tag loci mapping of the FAM167 A-BLK region, namely, rs11250144, rs2618431, rs4840568, rs13277113, rs2248932, rs2736340, and rs922483, in 999 AITD patients, including 624 Graves' disease (GD) and 375 Hashimoto's thyroiditis individuals, and 797 healthy cohorts. In contrast to those in controls, allele C of rs11250144 and allele G of rs2618431 both showed increased frequencies in GD patients. Read More

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November 2018
2 Reads
2.055 Impact Factor

Familial aggregation and heritability of type 1 diabetes mellitus and coaggregation of chronic diseases in affected families.

Clin Epidemiol 2018 10;10:1447-1455. Epub 2018 Oct 10.

Division or Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK,

Purpose: To estimate the extent of familial aggregation of type 1 diabetes (T1D) and coaggregation of related chronic diseases and assess the relative contribution of environmental and genetic factors on the risks.

Patients And Methods: This population-based study used the Taiwan National Health Insurance database to reconstruct family structure and identify people with T1D and other chronic diseases between 1999 and 2015. Relative risks (RRs) for T1D and other chronic diseases and heritability of T1D were estimated. Read More

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October 2018
1 Read

Acquired factor VII deficiency causing severe bleeding disorder secondary to AL amyloidosis of the liver.

Hematol Rep 2018 Sep 24;10(3):7235. Epub 2018 Sep 24.

Division of Medical Oncology & Hematology.

A 52 year-old male presented with neck pain after undergoing thyroidectomy for a goiter three weeks prior which was complicated by a neck hematoma requiring evacuation. Computed tomography (CT) scan showed a neck hematoma requiring evacuation and he received desmopressin with cessation of bleeding. Coagulation studies were normal. Read More

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September 2018
2 Reads

Outcome of radioactive iodine therapy in Toxic Nodular Goiter in Pakistan.

Pak J Med Sci 2018 Sep-Oct;34(5):1146-1151

Muhammad Areeb Ashfaq, Medical Student, Aga Khan University Hospital, Karachi, Pakistan.

Objective: To determine the outcome of patients receiving radioactive iodine therapy for toxic nodular goiter coming to Aga Khan University Hospital Karachi.

Methods: A total of 89 patients who visited the outpatient department of Aga Khan University Hospital from January 2010 to August 2017 were recruited for the study. Toxic nodular goiter was diagnosed on the basis of having hot nodule on thyroid scan with low TSH and high FT4/T4. Read More

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October 2018
6 Reads

Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism.

JCI Insight 2018 Oct 18;3(20). Epub 2018 Oct 18.

Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom (UK).

Defects in genes mediating thyroid hormone biosynthesis result in dyshormonogenic congenital hypothyroidism (CH). Here, we report homozygous truncating mutations in SLC26A7 in 6 unrelated families with goitrous CH and show that goitrous hypothyroidism also occurs in Slc26a7-null mice. In both species, the gene is expressed predominantly in the thyroid gland, and loss of function is associated with impaired availability of iodine for thyroid hormone synthesis, partially corrected in mice by iodine supplementation. Read More

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October 2018
2 Reads

Primary Epithelioid Angiosarcoma of the Thyroid in a Patient Occupationally Exposed to Radiations.

Front Endocrinol (Lausanne) 2018 1;9:577. Epub 2018 Oct 1.

Endocrinology of Aging Unit, Department of Medicine and Surgery, University of Parma, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.

Angiosarcoma (AS) of the thyroid is a rare and aggressive tumor. Its incidence is higher in iodine-deficient areas but cases unrelated to endemic goiter have been reported. We describe a case of a 63-year-old Italian man living in a non-iodine-deficient area, with no previous diagnosis of thyroid disease with a history of radiation exposure. Read More

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October 2018
3 Reads

ANNIVERSARY REVIEW: Antithyroid drug therapy: 70 years later

Eur J Endocrinol 2018 Oct 12;179(5):R261-R274. Epub 2018 Oct 12.

Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

The thionamide antithyroid drugs were discovered in large part following serendipitous observations by a number of investigators in the 1940s who found that sulfhydryl-containing compounds were goitrogenic in animals. This prompted Prof. Edwin B Astwood to pioneer the use of these compounds to treat hyperthyroidism in the early 1940s and to develop the more potent and less toxic drugs that are used today. Read More

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October 2018
1 Read

Clinical Significance of Thyroid-Stimulating Hormone Receptor Gene Mutations and/or Sodium-Iodine Symporter Gene Overexpression in Indeterminate Thyroid Fine Needle Biopsies.

Front Endocrinol (Lausanne) 2018 25;9:566. Epub 2018 Sep 25.

Section of Endocrinology, Diabetes and Nutrition, Boston Medical Center, Boston, MA, United States.

To examine the prevalence of genetic alterations of thyroid-stimulating hormone receptor () gene and sodium-iodine symporter () in a series of thyroid fine needle biopsy (FNB) specimens with indeterminate cytology, and to assess the correlation of the type of genetic changes with clinical features and follow-up results in the target thyroid nodule. Between February 2015 and September 2017, 388 consecutive FNBs with indeterminate cytology were evaluated for mutations and gene overexpression using ThyroSeqV.2 next-generation sequencing (NGS) panel. Read More

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September 2018
6 Reads

Radioactive iodine uptake in hyperthyroid cats after administration of recombinant human thyroid stimulating hormone.

J Vet Intern Med 2018 Nov 13;32(6):1891-1896. Epub 2018 Oct 13.

Departments of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, 48824.

Background: Radioactive iodine therapy is considered the treatment of choice for hyperthyroidism in cats, but the availability of this modality is limited by costs and hospitalization requirements. Administration of recombinant human thyroid stimulating hormone (rh-TSH) to humans with thyroid neoplasia or nodular goiter can increase thyroidal iodine uptake, thereby allowing the use of lower radioactive iodine doses for treatment. Veterinary studies of this subject are limited, and results are conflicting. Read More

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November 2018
1 Read

Regional Influences on Nutritional Iodine Status of Pregnant Women in Pakistan.

Thyroid 2018 Nov;28(11):1538-1546

1 Institute for Community Medicine, University Medicine Greifswald , Greifswald, Germany .

Background: Pregnant women are particularly vulnerable to iodine deficiency. Considering the rural-urban disparities in nutritional status in Pakistan, this study aimed to assess regional influences on nutritional iodine status of pregnant women in Pakistan.

Methods: Data were collected from 1246 pregnant women in all trimesters of pregnancy who visited antenatal clinics for routine checkups in five Khyber Pakhtunkhwa province districts. Read More

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November 2018
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Sexual function and depressive symptoms in men with overt hyperthyroidism.

Endokrynol Pol 2018 Oct 11. Epub 2018 Oct 11.

Introduction: Although hyperthyroidism is characterized by female predominance, its presence may lead to the development of numerous complications in both sexes. This study was aimed at investigating sexual function and depressive symptoms in men with overt hyperthyroidism of autoimmune and non-autoimmune origin.

Material And Methods: The study population consisted of three age-matched groups: men with overt hyperthyroidism and Graves' disease (group A; n=20), men with overt hyperthyroidism and toxic multinodular goiter or toxic adenoma (group B; n=21) and men with normal thyroid function (group C; n=23). Read More

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October 2018
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Long-term sequelae of the less than total thyroidectomy procedures for benign thyroid nodular disease.

Endocrine 2018 Oct 9. Epub 2018 Oct 9.

Second Department of Propaedeutic Surgery, Laiko University Hospital, Medical School, University of Athens, Athens, Greece.

Introduction: Nodular goiter is the most common disorder of the thyroid gland. Less than total thyroidectomy procedures are considered the gold standard in the surgical management of nodular thyroid disease despite its propensity for recurrence. The aim of the study was to assess long-term sequelae of the less than total thyroidectomy procedures. Read More

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October 2018

Overexpression of LASS2 inhibits proliferation and causes G0/G1 cell cycle arrest in papillary thyroid cancer.

Cancer Cell Int 2018 1;18:151. Epub 2018 Oct 1.

2College of Laboratory Medicine, Affiliated Hospital of ZunYi Medical College, Zunyi, 563003 Guizhou People's Republic of China.

Background: The aim of this study was to investigate the role of LAG1 longevity-assurance homologue 2 (LASS2) in papillary thyroid cancer (PTC).

Methods: Immunohistochemistry staining was conducted to explore the expression levels of LASS2 in PTC tissues and adjacent normal thyroid tissues and nodular goiter tissues. Western blotting and RT-qPCR were performed to explore the expression levels of LASS2 in three PTC cell lines (TPC-1, K1, BCPAP). Read More

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October 2018
3 Reads